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mortality atrial fibrillation

Xiaomao Fan, Qihang Yao, Yunpeng Cai, Fen Miao, Fangmin Sun, Ye Li
Atrial fibrillation (AF) is one of the most common sustained chronic cardiac arrhythmia in elderly population, associated with a high mortality and morbidity in stroke, heart failure, coronary artery disease, systemic thromboembolism, etc. The early detection of AF is necessary for averting the possibility of disability or mortality. However, AF detection remains problematic due to its episodic pattern. In this paper, a multi-scaled fusion of deep convolutional neural network (MSCNN) is proposed to screen out AF recordings from single lead short ECG recordings...
August 7, 2018: IEEE Journal of Biomedical and Health Informatics
Ravi K Chilukoti, Josefine Lendeckel, Katrin Darm, Alicja Bukowska, Andreas Goette, Marc Sühling, Kirsten Utpatel, Barbara Peters, Georg Homuth, Uwe Völker, Carmen Wolke, Christian Scharf, Uwe Lendeckel
Dronedarone improves microvascular flow during atrial fibrillation and reduces the infarct size in acute models of myocardial infarction. However, dronedarone might be harmful in patients with recent decompensated heart failure and increases mortality in patients with permanent atrial fibrillation. A pathophysiological explanation for these discrepant data is lacking. This study investigated the effects of dronedarone on gene and protein expression in the infarcted area and border zone in pigs subjected to anterior ischemia/reperfusion myocardial infarction...
July 2018: Experimental Biology and Medicine
Maximilian Spieker, Katharina Hellhammer, Jens Spießhöfer, Stratis Katsianos, Jan Balzer, Tobias Zeus, Patrick Horn, Malte Kelm, Ralf Westenfeld
Both pre-existing atrial fibrillation (AF) and mitral valve pressure gradients (MVPG) created by MitraClip implantation have demonstrated predictive power for unfavorable outcomes. Therefore, we aimed to assess the impact of MVPG following MitraClip on outcomes in patients with and without AF. A total of 200 patients who underwent MitraClip implantation in our institution were enrolled. Echocardiography was obtained before and after the procedure. The primary endpoint of the study was all-cause mortality 1-year after MitraClip implantation...
July 17, 2018: American Journal of Cardiology
Yingxu Ma, Fan Bai, Fen Qin, Yixi Li, Tao Tu, Chao Sun, Shenghua Zhou, Qiming Liu
BACKGROUND: There is a little evidence for the effects of catheter ablation (CA) on hard endpoints in patients with atrial fibrillation (AF) and heart failure (HF). METHODS: PubMed, Embase and Cochrane Library were searched for randomized controlled trials (RCTs) enrolling patients with AF and HF who were assigned to CA, rate control or medical rhythm control groups. This meta-analysis was performed by using random-effect models. RESULTS: Seven RCTs enrolling 856 participants were included in this meta-analysis...
August 13, 2018: BMC Cardiovascular Disorders
Zachary Tyerman, Robert B Hawkins, J Hunter Mehaffey, Mohammed Quader, Alan Speir, Leora T Yarboro, Gorav Ailawadi
BACKGROUND: Statins have potent pleiotropic effects that have been correlated with improved perioperative cardiovascular surgery outcomes. We hypothesize that statins may improve morbidity and mortality after ascending aortic surgery. METHODS: Within a statewide database consisting of 19 centers a total of 1,804 patients had ascending aortic repair with or without aortic valve replacement (2004-2016). Patients were stratified by preoperative statin therapy for analysis...
August 10, 2018: Seminars in Thoracic and Cardiovascular Surgery
Camilla Strøm, Jakob S Stefansson, Maria Louise Fabritius, Lars S Rasmussen, Thomas A Schmidt, Janus C Jakobsen
BACKGROUND: Short-stay units are hospital units that provide short-term care for selected patients. Studies have indicated that short-stay units might reduce admission rates, time of hospital stays, hospital readmissions and expenditure without compromising the quality of care. Short-stay units are often defined by a target patient category, a target function, and a target time frame. Hypothetically, short-stay units could be established as part of any department, but this review focuses on short-stay units that provide care for participants with internal medicine diseases and conditions...
August 13, 2018: Cochrane Database of Systematic Reviews
David Bode, Tim Guthof, Burkert M Pieske, Frank R Heinzel, Felix Hohendanner
In this article, we describe an optimized, Langendorff-based procedure for the isolation of single-cell atrial cardiomyocytes (ACMs) from a rat model of metabolic syndrome (MetS)-related heart failure with preserved ejection fraction (HFpEF). The prevalence of MetS-related HFpEF is rising, and atrial cardiomyopathies associated with atrial remodeling and atrial fibrillation are clinically highly relevant as atrial remodeling is an independent predictor of mortality. Studies with isolated single-cell cardiomyocytes are frequently used to corroborate and complement in vivo findings...
July 26, 2018: Journal of Visualized Experiments: JoVE
Ibrahim Sultan, Arturo Cardounel, Islam Abdelkarim, Arman Kilic, Andrew D Althouse, Michael S Sharbaugh, Aman Gupta, Jeff Xu, Miho Fukui, Marc A Simon, John T Schindler, Joon S Lee, Thomas G Gleason, João L Cavalcante
OBJECTIVES: To evaluate the prognostic value of the ratio between tricuspid annular plane systolic excursion (TAPSE)-pulmonary artery systolic pressure (PASP) as a determinant of right ventricular to pulmonary artery (RV-PA) coupling in patients undergoing transcatheter aortic valve replacement (TAVI). BACKGROUND: RV function and pulmonary hypertension (PH) are both prognostically important in patients receiving TAVI. RV-PA coupling has been shown to be prognostic important in patients with heart failure but not previously evaluated in TAVI patients...
August 9, 2018: Heart: Official Journal of the British Cardiac Society
Ramin Zand, Shima Shahjouei, Georgios Tsivgoulis, Mantinderpreet Singh, Michael McCormack, Nariman Noorbakhsh-Sabet, Nitin Goyal, Andrei V Alexandrov
BACKGROUND: Several studies have shown that cerebral microbleeds (CMBs) increase the risk of long-term stroke-related mortality. The purpose of this study was to determine if the existence and burden of CMBs are a predictor of in-hospital death among patients with acute ischemic stroke (AIS). METHODS: We studied consecutive ischemic stroke patients who admitted to our tertiary center over a 2-year period (2013-2014). Patients who underwent thrombolysis were excluded...
August 6, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Diana Baptista, Pedro Abreu, Elsa Azevedo, Rui Magalhães, Manuel Correia
BACKGROUND AND AIM: Stroke is a major health problem. Several studies reported sex differences regarding stroke. We aim to study this issue in an incidence stroke study. METHODS: Data were retrieved from a community-based prospective register of patients that had a first ever stroke in a life time between October 2009 and September 2011. We studied sex differences regarding demographic data, vascular risk factors, stroke type, stroke severity (NIHSS), disability at 28 days (modified Rankin scale (mRS)), and case fatality at 30 and 90 days...
August 6, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
John D Horowitz, Raffaele De Caterina, Tamila Heresztyn, John H Alexander, Ulrika Andersson, Renato D Lopes, Philippe Gabriel Steg, Elaine M Hylek, Puneet Mohan, Michael Hanna, Petr Jansky, Christopher B Granger, Lars Wallentin
BACKGROUND: There is little mechanistic information on factors predisposing atrial fibrillation (AF) patients to thromboembolism or bleeding, but generation of nitric oxide (NO) might theoretically contribute to both. OBJECTIVES: The authors tested the hypothesis that plasma levels of the methylated arginine derivatives asymmetric and symmetric dimethylarginine (ADMA/SDMA), which inhibit NO generation, might be associated with outcomes in AF. METHODS: Plasma samples were obtained from 5,004 patients with AF at randomization to warfarin or apixaban in the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial...
August 14, 2018: Journal of the American College of Cardiology
Felipe Gonzalez-Loyola, Rosa Abellana, José-Maria Verdú-Rotellar, Alejandro Bustamante Rangel, Josep Lluís Clua-Espuny, Miguel Angel Muñoz Pérez
BACKGROUND: The impact of atrial fibrillation (AF) on mortality of patients with heart failure (HF) has been established. Nevertheless, the effect of some factors in mortality, such as digoxin or diuretic use, remains controversial. This study aims at assessing mortality in community-dwelling patients with stable HF related to AF and determine the relation of these drugs with prognosis. MATERIALS AND METHODS: Community-based cohort study of HF patients diagnosed between January 2010 and December 2014, attended at any one of the 279 primary healthcare centers of the Catalan Institute of Health (Spain)...
August 9, 2018: European Journal of Clinical Investigation
Ageliki Laina, Aikaterini Gatsiou, Georgios Georgiopoulos, Kimon Stamatelopoulos, Konstantinos Stellos
Since our knowledge on structure and function of messenger RNA (mRNA) has expanded from merely being an intermediate molecule between DNA and proteins to the notion that RNA is a dynamic gene regulator that can be modified and edited, RNA has become a focus of interest into developing novel therapeutic schemes. Therapeutic modulation of RNA molecules by DNA- and RNA-based therapies has broadened the scope of therapeutic targets in infectious diseases, cancer, neurodegenerative diseases and most recently in cardiovascular diseases as well...
2018: Frontiers in Physiology
Gökhan Çetinkal, Cüneyt Koçaş, Betül Balaban Koçaş, Şükrü Arslan, Okay Abacı, Osman Şükrü Karaca, Yalçın Dalgıç, Özgür Selim Ser, Kudret Keskin, Ahmet Yıldız, Sait Mesut Doğan
OBJECTIVE: This study is designed to evaluate the recently developed AnTicoagulation and Risk factors In Atrial fibrillation (ATRIA) risk score (RS), which determines the predisposition to thromboembolic and hemorrhagic events in atrial fibrillation, as a predictor of prognosis in patients having acute myocardial infarction (AMI), and to compare the predictive ability of ATRIA RS with GRACE RS. METHODS: We analyzed 1627 patients having AMI who underwent coronary angiography and/or percutaneous coronary intervention (PCI) between January 2011 and February 2015...
August 2018: Anatolian Journal of Cardiology
Daniel E Jonas, Leila C Kahwati, Jonathan D Y Yun, Jennifer Cook Middleton, Manny Coker-Schwimmer, Gary N Asher
Importance: Atrial fibrillation is the most common arrhythmia and increases the risk of stroke. Objective: To review the evidence on screening for nonvalvular atrial fibrillation with electrocardiography (ECG) and stroke prevention treatment in asymptomatic adults 65 years or older to inform the US Preventive Services Task Force. Data Sources: MEDLINE, Cochrane Library, and trial registries through May 2017; references; experts; literature surveillance through June 6, 2018...
August 7, 2018: JAMA: the Journal of the American Medical Association
Z G Tatarintseva, E D Kosmachyeva, V A Porhanov
OBJECTIVE: to analyze patients with first-time developing atrial fibrillation (AF), against acute coronary syndrome (ACS), risk factors for arrhythmia, assessment of patients' adherence to oral anticoagulant therapy 6-24 months after the ACS episode, according to the total ACS registry for the Krasnodar Territory. MATERIALS AND METHODS: A retrospective analysis of the case histories of 13,244 patients admited to the infarction departments of all setlements of the Krasnodar Territory without exception and included in the ACS registry for the Krasnodar Territory from November 20, 2015 to January 20, 2018...
2018: Kardiologiia
Jessie S Channell, Stephan Schug
BACKGROUND: Tapentadol is a novel atypical opioid. Anecdotal evidence suggests that tapentadol has a lower toxicity than conventional opioids. OBJECTIVES: To evaluate all single-drug mortality due to tapentadol and assess serious adverse events caused by tapentadol. METHODS: The Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) reporting guidelines, an evidence-based minimum set of items for reporting in systematic reviews, were followed in this systematic review...
August 6, 2018: Pain Management
Vien T Truong, Eugene Chung, Sherif Nagueh, Dean Kereiakes, Jennifer Schaaf, Brian Volz, Tam N M Ngo, Wojciech Mazur
OBJECTIVES: To investigate the effect of transcatheter aortic valve replacement on left atrial volumetric function and left atrial volume for the prediction of adverse outcomes. METHODS: This is a retrospective analysis of 121 patients in sinus rhythm who underwent TAVR for severe AS. Maximum LA volume index (LAVI max), minimum LA volume index (LAVI min), and "pre-A" volume index (LAVIpre-A, the volume before atrial contraction) were measured by biplane Simpson's method at baseline, 1 month, and 1 year...
August 5, 2018: Echocardiography
Yasuo Okumura, Katsuaki Yokoyama, Naoya Matsumoto, Eizo Tachibana, Keiichiro Kuronuma, Koji Oiwa, Michiaki Matsumoto, Toshiaki Kojima, Shoji Hanada, Kazumiki Nomoto, Ken Arima, Fumiyuki Takahashi, Tomobumi Kotani, Yukitoshi Ikeya, Seiji Fukushima, Satoru Itou, Kunio Kondo, Masaaki Chiku, Yasumi Ohno, Motoyuki Onikura, Atsushi Hirayama
BACKGROUND: Although direct oral anticoagulants (DOACs) are widely used in Japanese patients with atrial fibrillation (AF), large-scale investigations into their use, with suitable follow-up times and rates, are lacking.Methods and Results:The SAKURA AF Registry is a prospective multicenter registry created to investigate therapeutic outcomes of oral anticoagulant (OAC) use in Japanese AF patients. We conducted a study involving 3,237 enrollees from 63 institutions in the Tokyo area being treated with any of 4 DOACs (n=1,676) or warfarin (n=1,561) and followed-up for a median of 39...
August 4, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Finlay A McAlister, Natasha Wiebe, Paul E Ronksley, Jeff S Healey
BACKGROUND: We investigated whether cardiovascular outcome patterns differ across atrial fibrillation (AF) subgroups defined by age, valvular status, newly diagnosed vs. prevalent cases, or anticoagulation status, and whether stroke risk models can accurately predict non-stroke outcomes. METHODS AND RESULTS: We performed a retrospective cohort study of all 147,952 adults with AF in Alberta, Canada between January 2008 and March 2014: 23,095 (15.6%) had at least one thromboembolic event (stroke, TIA, or systemic embolism) and 52,618 (35...
July 27, 2018: International Journal of Cardiology
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