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https://www.readbyqxmd.com/read/30315519/a-novel-homozygous-mutation-in-szt2-gene-in-saudi-family-with-developmental-delay-macrocephaly-and-epilepsy
#1
Muhammad Imran Naseer, Mohammad Khalid Alwasiyah, Angham Abdulrahman Abdulkareem, Rayan Abdullah Bajammal, Carlos Trujillo, Muhammad Abu-Elmagd, Mohammad Alam Jafri, Adeel G Chaudhary, Mohammad H Al-Qahtani
Epileptic encephalopathies are genetically heterogeneous disorders which leads to epilepsy and cause neurological disorders. Seizure threshold 2 (SZT2) gene located on chromosome 1p34.2 encodes protein mainly expressed predominantly in the parietal and frontal cortex and dorsal root ganglia in the brain. Previous studies in mice showed that mutation in this gene can confers low seizure threshold, enhance epileptogenesis and in human may leads to facial dysmorphism, intellectual disability, seizure and macrocephaly...
November 2018: Genes & Genomics
https://www.readbyqxmd.com/read/30312167/pharmacological-and-nutritive-potential-of-euphorbia-granulata
#2
Saeed Ahmad, Samya Perveen, Muhammad Adeel Arshad, Tayyeba Rehman
Background Euphorbia granulata is herb of family Euphorbiaceae having several traditional uses. The aim of the study is to summarize reported nutritional and medicinal value along with ethnomedical records. Methods The papers on nutritional and medicinal value of E. granulata are collected from electronic search engines (Google Scholar, PubMed). Synonyms are confirmed from "The plant List." Results Pharmacological studies suggest that the extracts of E. granulata possess antioxidant, antibacterial, antifungal, diuretic, antiulcerative colitis and spasmolytic properties...
October 12, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/30304939/the-association-between-hiv-infection-and-the-use-of-palliative-care-in-patients-hospitalized-with-heart-failure
#3
Shelli L Feder, Janet P Tate, Kathleen M Akgün, Julie A Womack, Sangchoon Jeon, Marjorie Funk, Roger J Bedimo, Matthew J Budoff, Adeel A Butt, Kristina Crothers, Nancy S Redeker
BACKGROUND: The number of adults with heart failure (HF) and HIV infection is increasing. These patients may benefit from palliative care (PC). OBJECTIVES: Determine the association between HIV infection, other HIV characteristics, and PC among hospitalized patients with HF in the Veterans Health Administration (VHA). DESIGN: Nested case-control study of patients with HF hospitalized from 2003 to 2015 and enrolled in the Veterans Aging Cohort Study...
October 10, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/30304160/assessment-of-skeletal-maturity-using-the-calcification-stages-of-permanent-mandibular-teeth
#4
Adeel Tahir Kamal, Attiya Shaikh, Mubassar Fida
INTRODUCTION: Knowledge of the growth status of patients is essential to formulate and initiate a precise treatment plan. This study aimed at determining the role of calcification of permanent mandibular teeth for the assessment of skeletal maturity. METHODS: A cross-sectional study was conducted using lateral cephalograms and dental panoramic radiographs of 360 patients (ages 7-18 years) equally divided into six groups according to cervical vertebral maturation stages...
August 1, 2018: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/30294438/preliminary-radiological-result-after-establishment-of-hospital-based-trauma-registry-in-level-1-trauma-hospital-in-developing-country-setting-prospective-cohort-study
#5
Obada Hasan, Adeel Samad, Zohaib Nawaz, Tashfeen Ahmad, Zehra Abdul Muhammad, Shahryar Noordin
Introduction: Injuries are the second most common cause of disability, the fifth most common cause of healthy years of life lost per 1000 people and unfortunately 90% of mortality takes place in low-to middle-income countries. Trauma registries guide policymakers and health care providers in decision making in terms of resource allocation as well as enhancing trauma care outcomes. Furthermore data from these registries inform policy makers to decrease the rate of death and disability occurring as a result of injuries...
November 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/30292158/uptake-and-transformation-of-steroid-estrogens-as-emerging-contaminants-influence-plant-development
#6
Muhammad Adeel, Y S Yang, Y Y Wang, X M Song, M Arslan Ahmad, Hilary J Rogers
Steroid estrogens are emerging contaminants of concern due to their devastating effects on reproduction and development in animals and humans at very low concentrations. The increasing steroid estrogen in the environment all over the world contrasts very few studies for potential impacts on plant development as a result of estrogen uptake. This study evaluated the uptake, transformation and effects of estradiol (17β-E2) and ethinyl estradiol (EE2) (0.1-1000 μg L-1 ) on lettuce. Uptake increased in leaves and roots in a dose-dependent manner, and roots were the major organ in which most of the estrogen was deposited...
September 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/30282953/m-polynomials-and-degree-based-topological-indices-of-the-crystallographic-structure-of-molecules
#7
Wei Gao, Muhammad Younas, Adeel Farooq, Abid Mahboob, Waqas Nazeer
Topological indices are numerical parameters used to study the physical and chemical properties of compounds. In quantitative structure⁻activity relationship QSARs, topological indices correlate the biological activity of compounds with their physical properties like boiling point, stability, melting point, distortion, and strain energy etc. In this paper, we determined the M-polynomials of the crystallographic structure of the molecules Cu₂O and Ti F₂ [ p,q,r ]. Then we derived closed formulas for some well-known topological indices using calculus...
October 3, 2018: Biomolecules
https://www.readbyqxmd.com/read/30279120/preoperative-embolization-of-skull-base-meningiomas-a-systematic-review
#8
REVIEW
Adeel Ilyas, Colin Przybylowski, Ching-Jen Chen, Dale Ding, Paul M Foreman, Thomas J Buell, Davis G Taylor, M Yashar Kalani, Min S Park
Neoadjuvant endovascular embolization of skull base meningiomas may facilitate surgical resection, thereby potentially decreasing operative morbidity. However, due to variation in the reported efficacy and complication rates, the utility of embolization remains incompletely defined. The aim of this systematic review is to assess the outcomes of preoperative embolization for skull base meningiomas. A literature review was performed to identify studies reporting outcomes of patients with skull base meningiomas who underwent preoperative embolization...
September 29, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30262699/detection-of-c-139g-a-d47n-mutation-in-gja8-gene-in-an-extended-family-with-inheritance-of-autosomal-dominant-zonular-cataract-without-pulverulent-opacities-by-exome-sequencing
#9
Padma Gunda, Mamata Manne, Syed Saifuddin Adeel, Ravi Kumar Reddy Kondareddy, Padma Tirunilai
The aim of this studywas to identify the gene causing bilateral autosomal dominant zonular congenital cataract (ADZCC) without pulverulent opacities in an extended Muslim family by exome sequencing and subsequent analysis. An extended family of 37 members (14 affected and 23 unaffected) who belong to different nuclear families was screened for causative gene. Proband and her unaffected son were screened for causative variant by exome sequencing followed by Sanger sequencing of the proband's entire nuclear family...
September 2018: Journal of Genetics
https://www.readbyqxmd.com/read/30261989/disconnect-of-type-2-biomarkers-in-severe-asthma-dominated-by-feno-as-a-predictor-of-exacerbations-and-periostin-as-predictor-of-reduced-lung-function
#10
Adel H Mansur, Sapna Srivastava, Adeel Sahal
BACKGROUND: biomarkers of Type 2 (T2) inflammation may predict asthma control and exacerbation risk. However, the relationships between individual T2 biomarkers to exacerbations and lung function in severe asthma remain uncertain. OBJECTIVES: to explore the roles played by T2 biomarkers individually and as a composite score in predicting clinical outcomes in severe asthma. METHODS: unselected severe asthma patients were enrolled in this cross sectional real life study...
October 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/30261251/graphene-and-graphene-oxide-functionalization-and-nano-bio-catalytic-system-for-enzyme-immobilization-and-biotechnological-perspective
#11
REVIEW
Muhammad Adeel, Muhammad Bilal, Tahir Rasheed, Ashutosh Sharma, Hafiz M N Iqbal
Graphene-based nanomaterials have gained high research interest in different fields related to proteins and thus are rapidly becoming the most widely investigated carbon-based materials. Their exceptional physiochemical properties such as electrical, optical, thermal and mechanical strength enable graphene to render graphene-based nanostructured materials suitable for applications in different fields such as electroanalytical chemistry, electrochemical sensors and immobilization of biomolecules and enzymes...
September 24, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30247956/integrative-wellness-for-patients-receiving-proton-therapy-a-patient-centered-collaboration
#12
Delia Chiaramonte, Adeel Kaiser, Griffin McMath, Charles B Simone, William F Regine, Brian Berman
No abstract text is available yet for this article.
September 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/30223168/comparative-effects-of-nano-and-bulk-fe-3-o-4-on-the-growth-of-cucumber-cucumis-sativus
#13
Alexandre Konate, Yaoyao Wang, Xiao He, Muhammd Adeel, Peng Zhang, Yuhui Ma, Yayun Ding, Junzhe Zhang, Jie Yang, Simon Kizito, Yukui Rui, Zhiyong Zhang
Cucumber (Cucumis sativus) plants were cultivated in hydroponic media with nano and bulk- iron oxide (Fe3 O4 ) (50, 500 and 2000 mg/L) over a period of 21 days. At the low concentration (50 mg/L), nano-Fe3 O4 resulted in reduction of biomass and enzyme activities compared to the control. However, at the higher concentration of nano-Fe3 O4 dosage (2000 mg/L), there was a significant increase in biomass, antioxidant enzymes superoxide dismutase (SOD) and peroxidase (POD). In contrary, the high concentration of bulk-Fe3 O4 caused phytotoxicity in terms of biomass and enzymes activity...
September 14, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/30218427/pnpla3-gene-polymorphisms-in-hcv-hiv-coinfected-individuals
#14
Kenneth E Sherman, Susan D Rouster, Minhee Kang, Triin Umbleja, Richard Sterling, Adeel A Butt
BACKGROUND AND AIMS: The patatin-like phospholipase domain-containing 3 (PNPLA3) gene has been associated with the development of alcoholic and nonalcoholic steatohepatitis. Using a newly developed and validated assay for PNPLA3, we explored the prevalence of gene polymorphisms in a cohort of HCV/HIV-coinfected individuals to determine whether there was an association with insulin resistance or hepatic fibrosis. METHODS: A high-resolution melting point (HRM) assay was developed and validated...
September 14, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30215208/levels-distribution-and-sources-of-organophosphate-flame-retardants-and-plasticizers-in-urban-soils-of-shenyang-china
#15
Qing Luo, Yue Shan, Adeel Muhammad, Shiyu Wang, Lina Sun, Hui Wang
Seventy-four soil samples from the road greenbelts, residential areas, drylands, waste grasslands, education lands, industrial areas, city parks, and rural homesteads of Shenyang city, China, were collected and analyzed for 13 organophosphate esters (OPEs). OPEs were detected in all analyzed soil samples, which indicate that OPEs are ubiquitously environmental contaminants. The ∑13 OPEs concentrations ranged from 0.039 to 0.95 mg/kg dry weight (dw), with the mean and median concentrations of 0.23 and 0.16 mg/kg dw, respectively...
November 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30214841/post-football-gonathrosis-injuries-and-surgeries-are-a-risk
#16
REVIEW
Muhammad Mannan Ali Khan, Adeel A Siddiqui, Uzair Yaqoob, Muhammad Danial Yaqub, Osama J Khan, Faizan -Ul-Haq
Football is one of the most popular sports in the world. Many studies have shown there is a high incidence of gonarthrosis in football players. The reason for this increase is said to be injuries to the meniscus, the anterior cruciate ligament (ACL) and the resulting surgeries. The incidence is significantly increased in players with knee injuries. The knee is also the most commonly injured site in football and the most common cause of surgery in football players. Together these injuries, particularly of the ACL or meniscus and the resulting surgeries, increase the risk of developing gonarthrosis in post-football years...
July 10, 2018: Curēus
https://www.readbyqxmd.com/read/30173691/cerebral-abscess-caused-by-novel-species-streptococcus-pluranimalium
#17
Abeera Ahmed, Gohar Zaman, Adeel Gardezi, Luqman Satti, Nargis Sabir, Aliya Haleem
Streptococcus pluranimalium, a gram-positive aerobic coccus, has been isolated primarily from several farm animals. The pathogenicity of this species is not well characterised either in animals or humans. As per the literature, cases of S. pluranimalium infection in humans have been reported only a handful of times. We report the case of cerebral abscess caused by S. pluranimalium in a patient who presented with weakness and confusion. The diagnosis of cerebral abscess was made on imaging supported by microbiological culture...
September 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/30165254/variability-and-reliability-of-effective-connectivity-within-the-core-default-mode-network-a-multi-site-longitudinal-spectral-dcm-study
#18
Hannes Almgren, Frederik Van de Steen, Simone Kühn, Adeel Razi, Karl Friston, Daniele Marinazzo
Dynamic causal modelling (DCM) for resting state fMRI - namely spectral DCM - is a recently developed and widely adopted method for inferring effective connectivity in intrinsic brain networks. Most applications of spectral DCM have focused on group-averaged connectivity within large-scale intrinsic brain networks; however, the consistency of subject- and session-specific estimates of effective connectivity has not been evaluated. Establishing reliability (within subjects) is crucial for its clinical use; e...
August 27, 2018: NeuroImage
https://www.readbyqxmd.com/read/30149174/seizure-outcomes-after-radiosurgery-for-cerebral-arteriovenous-malformations-an-updated-systematic-review-and-meta-analysis
#19
REVIEW
Natasha Ironside, Ching-Jen Chen, Dale Ding, Adeel Ilyas, Jeyan S Kumar, Thomas J Buell, Davis Taylor, Cheng-Chia Lee, Jason P Sheehan
OBJECTIVE: The seizure outcomes for patients with brain arteriovenous malformations (AVM) who undergo intervention with stereotactic radiosurgery (SRS) are incompletely understood. We sought to determine, in a systematic review and meta-analysis, the rates of seizure control after SRS for patients with AVM-associated seizures and identify predictive factors. METHODS: We performed a systematic review of PubMed and MEDLINE databases from January 1987 to January 2018, in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
August 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30137251/trends-in-treatment-uptake-and-provider-specialty-for-hcv-infection-in-the-va-healthcare-system-results-from-erchives
#20
Adeel A Butt, Peng Yan, Vincent Lo Re, Obaid S Shaikh, David B Ross
Between 2001-2017, 108,133 persons (45.7% of diagnosed cases) were initiated on anti-HCV treatment in the VA healthcare system. In 2017, non-MD clinicians accounted for 22.2% of prescriptions, infectious diseases specialists for 14.9% and gastroenterologists/hepatologists for 10.3%. In the pre-DAA era, they accounted for 7.2%, 26.7% and 11.6% respectively.
August 22, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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