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Young Chel Kwun, Adeel Farooq, Waqas Nazeer, Zohaib Zahid, Saba Noreen, Shin Min Kang
Topological indices correlate certain physicochemical properties like boiling point, stability, and strain energy of chemical compounds. In this report, we compute M-polynomials for PAMAM dendrimers and polyomino chains. Moreover, by applying calculus, we compute nine important topological indices of under-study dendrimers and chains.
2018: International Journal of Analytical Chemistry
Tahir Rasheed, Muhammad Bilal, Faran Nabeel, Muhammad Adeel, Hafiz M N Iqbal
In recent years, emerging contaminants (ECs) of high concern are broadly distributed throughout the environmental matrices because of various industrial practices and anthropogenic inputs, i.e., human-made activities. With ever increasing scientific knowledge, technological advancement, socio-economic awareness, people are now more concern about the widespread distribution of environmentally related ECs of high concern. As, ECs possess serious ecological threats and potential risks to human health and aquatic life, even at minor concentrations...
November 28, 2018: Environment International
Muhammad Y Adeel, John-Ross D Clarke, Safal Shetty, Ashish Arora, Michael G Buscher
We report the case of a 52-year-old gentleman, admitted to the medical intensive care unit with multiple organ system dysfunction due to acute severe pancreatitis. He was found to have severe hypocalcemia, bradycardia and an electrocardiogram (EKG) showing ST-segment elevation in infero-lateral leads. The patient was treated with intravenous calcium gluconate with prompt improvement of heart rate and reversal of EKG changes. Subsequent evaluation for myocardial ischemia was negative. We believe the EKG changes mimicking acute ST-segment elevation myocardial infarction were due to severe hypocalcemia...
December 2018: Oxford Medical Case Reports
Sarah H Siddiqui, Tahira H Siddiqui, Masood U Babar, Adeel Khoja, Sara Khan
Outcomes of Guillain Barre Syndrome (GBS), particularly those require mechanical ventilation have been reported from a number of Asian countries, albeit, scarcely from Pakistan. We conducted this study to determine the short-term outcomes of GBS and compare the results of mechanically ventilated and non-ventilated patients. Case records of patients admitted with GBS during 2011-2016 at a large tertiary care centre of Pakistan were retrospectively reviewed. 216 patients satisfying inclusion criteria were included...
November 23, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Muhammad Rashid, Haroon Akbar, Amir Bakhsh, Muhammad Imran Rashid, Muhammad Adeel Hassan, Rahmat Ullah, Tahir Hussain, Sohail Manzoor, Hong Yin
Coccidiosis is one of the most economically important diseases of the poultry, around the globe. In order to assess seasonal and age-wise prevalence of coccidiosis individually and with concurrent infections, this study was conducted on commercial poultry farms in and around Multan division, province of Punjab, Pakistan. A total of 28,126 boilers, 4,052 layers and 7,699 golden bird samples, provided by regional farmers and consultants, were examined by microscopy for the diagnosis of coccidiosis. Based on postmortem lesions, several infections including coccidiosis, viral, and miscellaneous diseases were catalogued, whereas samples were cultured to identify concurrent bacterial diseases...
November 24, 2018: Poultry Science
Raheela Bano, Adeel Arsalan
Antibiotics are not only used in morbidity but also help in prevention of infection. The irrational use of broad spectrum antibiotics is now increasing the resistance against pathogens. This present study has been carried out to evaluate the in-vitro antibacterial effect of levofloxacin against clinical isolates. According to Clinical and Laboratory Standards Institute (CLSI) guidelines, minimum inhibitory concentrations 90% (MIC90 ) of the levofloxacin tested were evaluated by an agar dilution method. Total 63 clinical isolates Staphylococcus aureus (n=34) and Escherichia coli (n=29) were collected from different hospitals at Karachi and were evaluated MIC90 of eleven different brands of levofloxacin tablet (250 mg)...
November 2018: Pakistan Journal of Pharmaceutical Sciences
Azmat Ali Shah, Ahsan Rasool, Muhammad Adeel Alam, Yasir Naseem, Maleeha Rasool, Atif Hussain, Shandana Jadoon, Ejaz Hussain Shah, Attique Afzal Malik, Naveed Ahmed
BACKGROUND: Spinal anaesthesia causes hypotension that is countered through various methods. Phenylephrine is a vasoconstrictor and haemocoel increases the intravascular vascular volume; both have an effect in preventing this hypotension; but their comparison has not been done in local setting. METHODS: Randomized control trial was conducted in month of June, 2017 at Ayub Teaching Hospital, Abbottabad. Block randomization with sealed envelopes was employed. Sample size was set at 90...
July 2018: Journal of Ayub Medical College, Abbottabad: JAMC
Qian Zhang, Zhe Liang, Xuean Cui, Changmian Ji, Yun Li, Pingxian Zhang, Jingrong Liu, Adeel Riaz, Pu Yao, Min Liu, Yunpeng Wang, Tiegang Lu, Hao Yu, Donglei Yang, Hongkun Zheng, Xiaofeng Gu
N6 -Methyladenine (6mA) DNA methylation has recently been implicated as a potential new epigenetic marker in eukaryotes, including the dicot model Arabidopsis thaliana. However, the conservation and divergence of 6mA distribution patterns and functions in plants remain elusive. Here we report high-quality 6mA methylomes at single-nucleotide resolution in rice based on substantially improved genome sequences of two rice cultivars, Nipponbare (Nip; Japonica) and 93-11 (Indica). Analysis of 6mA genomic distribution and its association with transcription suggest that 6mA distribution and function is rather conserved between rice and Arabidopsis...
November 15, 2018: Molecular Plant
Adeel A Butt, Peng Yan, Ashfaq Shuaib, Abdul-Badi Abou-Samra, Obaid S Shaikh, Matthew S Freiberg
BACKGROUND & AIMS: Infection with hepatitis virus C (HCV) is associated with an increased risk of cardiovascular disease (CVD) events. It is not clear whether treatment with direct-acting antiviral (DAA) agents affects risk of CVD. METHODS: We searched the Electronically Retrieved Cohort of HCV-infected Veterans database for patients with chronic HCV infection (n=242,680), identifying patients who had been treated with a pegylated interferon and ribavirin regimen (n=4436) or a DAA-containing regimen (12,667)...
November 13, 2018: Gastroenterology
Nargis Sabir, Aamer Ikram, Adeel Gardezi, Gohar Zaman, Luqman Satti, Abeera Ahmed, Tahir Khadim
Introduction: Infective endocarditis (IE) is an important clinical condition with significant morbidity and mortality among the affected population. A single etiological agent is identifiable in more than 90 % of the cases, however, polymicrobial endocarditis (PE) is a rare find, with a poor clinical outcome. Here we report a case of native valve dual pathogen endocarditis caused by Burkholderia cepacia and Aspergillus flavus in an immunocompetent individual. It is among unique occurrences of simultaneous bacterial and fungal etiology in IE...
September 2018: JMM Case Reports
Christopher T Rentsch, Janet P Tate, Tessa Steel, Adeel A Butt, Cynthia L Gibert, Laurence Huang, Margaret Pisani, Guy W Soo Hoo, Stephen Crystal, Maria C Rodriguez-Barradas, Sheldon T Brown, Matthew S Freiberg, Christopher J Graber, Joon W Kim, David Rimland, Amy C Justice, David A Fiellin, Kristina A Crothers, Kathleen M Akgün
BACKGROUND: HIV, hepatitis C virus (HCV), and alcohol-related diagnoses (ARD) independently contribute increased risk for all-cause hospitalization. We sought to determine annual medical intensive care unit (MICU) admission rates and relative risk of MICU admission between 1997 and 2014 among people with and without HIV, HCV, and ARD, using data from the largest HIV and HCV care provider in the United States. SETTING: Veterans Health Administration. METHODS: Annual MICU admission rates were calculated among 155,550 patients in the Veterans Aging Cohort Study by HIV, HCV, and ARD status...
October 29, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Magnus Berle, Luiza Ghila, Heidrun Vethe, Adeel Chaudhry, Hilde Garberg, Christian Beisland, Øystein Ariansen Haaland, Eystein Oveland, Ole Johan Halvorsen, Thomas Davidsson, Simona Chera
Patients with bladder cancer need frequent controls over long follow-up time due to high recurrence rate and risk of conversion to muscle invasive cancer with poor prognosis. We identified cancer-related molecular signatures in apparently healthy bladder in patients with subsequent muscular invasiveness during follow-up. Global proteomics of the normal tissue biopsies revealed specific proteome fingerprints in these patients prior to subsequent muscular invasiveness. In these presumed normal samples, we detected modulations of proteins previously associated with different cancer types...
2018: PloS One
Fawad Ahmad Randhawa, Nasir Farooq Butt, Syed Osama Talat, Sajjad Hussain Sabir, Muhammad Adeel Qamar
OBJECTIVE: To compare the improvement of dilatation among patients receiving intralesional steroid injection with dilatation versus dilatation alone for the management of corrosive ooesophageal strictures. METHODS: The randomized controlled trial was conducted at Mayo Hospital, Lahore, Pakistan, from November 10, 2014, to November 10, 2015, and comprised patients of either gender aged 15-50years who had corrosive ooesophageal stricture. They were randomised into 2 groups by using the lottery method...
November 2018: JPMA. the Journal of the Pakistan Medical Association
Mohammad Adeel, Moghira Iqbal Siddiqi
Objectives: The aim of this study was to determine the incidence and characteristics of second primary malignancy (SPM) in patients with head and neck squamous cell carcinoma treated at a tertiary care hospital. Materials and Methods: We retrospectively reviewed the medical records of 221 patients who underwent surgery with or without adjuvant treatment for head and neck cancer from 2000 to 2002. Data of age, sex, risk factors, sites of primary and SPM, TNM stage of primary tumor, incidence of SPM, and survival were collected from medical charts...
October 2018: Journal of the Korean Association of Oral and Maxillofacial Surgeons
Muhammad Adeel, Md Mahbubur Rahman, Jae-Joon Lee
A novel electrochemical aptasensor based on gold nanoparticles decorated on boron nitride nanosheets (AuNPs/BNNSs) for the sensitive and selective detection of myoglobin (Mb) is reported. BNNSs were chemically synthesized by a low-cost and simple hydrothermal method. They were deposited onto the fluorine-doped tin oxide (FTO) electrode by a spin-coating method. Subsequently, AuNPs were chemically deposited onto the BNNS/FTO electrode by a seed-mediated chemical reduction method, with an average particle size of approximately 10 nm...
October 29, 2018: Biosensors & Bioelectronics
Angham Abdulrahman Abdulkareem, Khalid Omar Abulnaja, Mohammad M Jan, Sajjad Karim, Mahmood Rasool, Shakeel Ahmed Ansari, Adeel G Chaudhary, Mohammad H Al-Qahtani, Muhammad Imran Naseer
Progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome is an unusual Mendelian phenotype of unidentified origin that causes profound intellectual disability, optic nerve/cerebellar atrophy, epileptic seizures, developmental progress, pedal edema, and early death. Uncharacteristic affected individuals are often classified as having PEHO-like syndrome, although they may be misdiagnosed as having epileptic encephalopathy, a potential result of early birth. In this study, we report a consanguineous Saudi family with a novel homozygous nonsense mutation of the CCDC88A gene causing PEHO-like syndrome...
November 3, 2018: Neurological Sciences
Muhammad Tahir Ul Qamar, Amna Bari, Muhammad Muzammal Adeel, Arooma Maryam, Usman Ali Ashfaq, Xiaoyong Du, Iqra Muneer, Hafiz Ishfaq Ahmad, Jia Wang
BACKGROUND: Chikungunya virus (CHIKV), causes massive outbreaks of chikungunya infection in several regions of Asia, Africa and Central/South America. Being positive sense RNA virus, CHIKV replication within the host resulting in its genome mutation and led to difficulties in creation of vaccine, drugs and treatment strategies. Vector control strategy has been a gold standard to combat spreading of CHIKV infection, but to eradicate a species from the face of earth is not an easy task...
October 27, 2018: Journal of Translational Medicine
Adeel Ikram, Kriti Singhania, Suhayl Tafazal, Amol Tambe
We present a challenging case of proximal humerus varus deformity in a four-limb amputee, caused by growth arrest from meningococcal septicaemia. The deformity resulted in a loss of function for our patient with inhibition of activities of daily living, requiring corrective osteotomy to help improve the range of motion of the shoulder. We describe in detail the management of our patient, highlight the importance of the orthopaedic manifestations of meningococcal septicaemia, and demonstrate the importance of monitoring potential deformities from growth arrest in these patients...
October 25, 2018: BMJ Case Reports
Adeel Aqil, Sanya Patel, Anatole Wiik, Gareth Jones, Alex Bridle, Justin P Cobb
The role of patient-specific (PS) technology in total hip arthroplasty remains relatively unexplored. We asked whether PS guides: (1) Reduced average surgical errors? (2) Reduced outlier error frequencies? (3) Could predict the size of implants used? A single surgeon implanted femurs using either standard or PS guides and was blinded to the pre-operative plans. There were significant differences in median leg length errors between standard (3.3 mm) and PS groups (1.4 mm), U = 110, z = -2.3, p = 0...
October 26, 2018: Computer Methods in Biomechanics and Biomedical Engineering
Vikram Khanna, Adeel Shahzad, Kala Thayalasamy, Ian Kemp, Christine Mars, Rob Cooper, Claire Roome, Keith Wilson, Scott Harris, Rod Stables, Nick Curzen
In randomised trials, bivalirudin has been associated with higher rates of acute stent thrombosis (AST) compared to unfractionated heparin (UFH), without mechanistic explanation. Furthermore, data are discrepant regards the antiplatelet effects of bivalirudin. This prespecified study, part of a larger HEAT-PPCI Platelet Substudy, aimed to compare the antiplatelet and antithrombotic effects of bivalirudin and UFH using short thrombelastography (s-TEG), an ex vivo whole blood platelet function assay. In HEAT-PPCI, patients were randomised to receive UFH or bivalirudin before angiography...
September 28, 2018: Thrombosis Research
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