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Curcumin and celebrex study

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https://www.readbyqxmd.com/read/27133426/small-molecule-tolfenamic-acid-and-dietary-spice-curcumin-treatment-enhances-antiproliferative-effect-in-pancreatic-cancer-cells-via-suppressing-sp1-disrupting-nf-kb-translocation-to-nucleus-and-cell-cycle-phase-distribution
#1
Riyaz Basha, Sarah F Connelly, Umesh T Sankpal, Ganji Purnachandra Nagaraju, Hassaan Patel, Jamboor K Vishwanatha, Sagar Shelake, Leslie Tabor-Simecka, Mamoru Shoji, Jerry W Simecka, Bassel El-Rayes
Combination of dietary/herbal spice curcumin (Cur) and COX inhibitors has been tested for improving therapeutic efficacy in pancreatic cancer (PC). The objective of this study was to identify agent with low toxicity and COX-independent mechanism to induce PC cell growth inhibition when used along with Cur. Anticancer NSAID, tolfenamic acid (TA) and Cur combination were evaluated using PC cell lines. L3.6pl and MIA PaCa-2 cells were treated with Cur (5-25μM) or TA (25-100μM) or combination of Cur (7.5μM) and TA (50μM)...
May 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/21504136/docosahexaenoic-acid-reduces-amyloid-%C3%AE-1-42-secretion-in-human-a%C3%AE-pp-transfected-cho-cells-by-mechanisms-other-than-inflammation-related-to-pge%C3%A2
#2
COMPARATIVE STUDY
Martijn C de Wilde, Eline M van der Beek, Amanda J Kiliaan, Inge Leenders, Almar A M Kuipers, Patrick J Kamphuis, Laus M Broersen
The effect of supplementation with the omega 3 polyunsaturated fatty acid (n3 PUFA) docosahexaenoic acid (DHA) on membrane composition and amyloid-β₁₋₄₂ (Aβ₄₂) secretion was studied in human amyloid-β protein precursor-transfected Chinese Hamster Ovary (CHO) cells. Twenty-four hour incubation with a range of DHA concentrations resulted in a dose-dependent increase in membrane DHA and eicosapentaenoic acid content and a decrease in arachidonic acid content. In addition, DHA supplementation caused a dose-dependent reduction in the secreted Aβ₄₂ levels and resulted in a 4-8 fold decrease in extracellular prostaglandin E₂ (PGE₂) levels...
2010: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/18289124/compositions-for-treatment-of-cancer-and-inflammation
#3
REVIEW
Shahar Lev-Ari, Dov Lichtenberg, Nadir Arber
Celecoxib (Celebrex, Pfizer, NY, USA) is a worldwide top branded COX-2-specific inhibitor. It was shown to provide relief of arthritic pain and inflammation and has recently been under investigation for the prevention and treatment of cancer. However, recent studies showed that long term use of high doses of celecoxib is associated with an increased cardiovascular toxicity. We discovered that the addition of curcumin, a natural COX-2 inhibitor, to celecoxib synergistically (up to 1000%) augments the growth inhibitory effects of celecoxib in in-vitro and in-vivo models of arthritis and cancer, thus rendering effective action of the drug at up to tenfold lower dose...
January 2008: Recent Patents on Anti-cancer Drug Discovery
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