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https://www.readbyqxmd.com/read/30100111/robotic-versus-open-partial-nephrectomy-for-highly-complex-renal-masses-comparison-of-perioperative-functional-and-oncological-outcomes
#1
Juan Garisto, Riccardo Bertolo, Julien Dagenais, Daniel Sagalovich, Khaled Fareed, Amr Fergany, Robert Stein, Jihad Kaouk
INTRODUCTION: We aimed to compare perioperative, functional and oncological outcomes between robot-assisted partial nephrectomy (RAPN) and open partial nephrectomy (OPN) for highly complex renal tumors (R.E.N.A.L. nephrometry Score > 9). METHODS: A retrospective review of 1,497 patients who consecutively underwent partial nephrectomy at a single academic tertiary center between 2008 and 2016 was performed to get data about patients who underwent RAPN and OPN for renal masses with RENAL score > 9...
August 9, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/30073601/evolution-of-a-novel-robotic-training-curriculum-in-a-complex-general-surgical-oncology-fellowship
#2
L Mark Knab, Mazen S Zenati, Anton Khodakov, Maryjoe Rice, Amr Al-Abbas, David L Bartlett, Amer H Zureikat, Herbert J Zeh, Melissa E Hogg
BACKGROUND: Robotic surgery is increasingly being used for complex oncologic operations, although currently there is no standardized curriculum in place for surgical oncologists. We describe the evolution of a proficiency-based robotic training program implemented for surgical oncology fellows, and demonstrate the outcomes of the program. METHODS: A 5-step robotic curriculum began integration in July 2013. Fellows from July 2013 to August 2017 were included. An education portfolio was created for each fellow, including pre-fellowship experience, fellowship experience with data from robotic curriculum and operative experience, and post-fellowship practice information...
August 2, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30031812/cenp-e-as-a-target-for-cancer-therapy-where-are-we-now
#3
REVIEW
Amr Ahmed El-Arabey, Salama Abdu Salama, Adel Rashad Abd-Allah
In 2015, more than 1.6 million new cancer cases with 589,430 deaths were estimated over worldwide. Cancer is a complex disease with abnormal cell growth control which is hallmarked by chromosome misalignment and consequently genomic instability. Mitosis is a well-known target for chemotherapy as taxol and colchicines inhibit tumor cell division by inhibiting mitotic spindle plasticity. Accumulating evidence has revealed that the Centromere-associated protein E (CENP-E) is expressed during mitosis and plays critical roles in inaccurate chromosome alignment...
July 19, 2018: Life Sciences
https://www.readbyqxmd.com/read/29691094/first-experience-of-the-egyptian-national-cancer-institute-using-the-robot-assisted-laparoscopic-approach-in-radical-hysterectomies-for-cervical-cancer
#4
Ashraf Saad Zaghloul, Ahmed Mahmoud El-Minawi, Mohamed Atef ElKordy, Amr Kamal Younes, Ahmed Mostafa Mahmoud, Waleed Mohamed Fadlalla, Gamal Amira Mohamed
AIM OF WORK: Robotics in surgery led to an improvement of visualization, a better handling of tissues and better suturing. This study aimed to document the first experience of the Egyptian National Cancer Institute (NCI) using the robot-assisted laparoscopic approach in radical hysterectomies for cervical cancer and to highlight observed advantages, disadvantages, morbidity and oncological outcomes. PATIENTS AND METHODS: Data of cases that had either early cervical cancer (stage IB-IIA1 with a tumor ≥2 cm) or locally advanced cervical cancer (Stage IIA2-IIB after chemo-radiotherapy) were collected prospectively...
June 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29290810/tumour-vascular-shutdown-and-cell-death-following-ultrasound-microbubble-enhanced-radiation-therapy
#5
Ahmed El Kaffas, Mehrdad J Gangeh, Golnaz Farhat, William Tyler Tran, Amr Hashim, Anoja Giles, Gregory J Czarnota
High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation effects with conventional radiation doses. This study aimed to confirm acute and longitudinal relationships between vascular shutdown and tumour cell death following radiation and USMB in a wild type murine fibrosarcoma model using in vivo imaging. Methods: Tumour xenografts were treated with single radiation doses of 2 or 8 Gy alone, or in combination with low-/high-concentration USMB...
2018: Theranostics
https://www.readbyqxmd.com/read/28385045/long-term-outcomes-of-laparoscopic-nephroureterectomy-with-transurethral-circumferential-excision-of-the-ureteral-orifice-for-urothelial-carcinoma
#6
Aakash Pai, Muddassar Hussain, Richard Hindley, Amr Emara, Neil Barber
INTRODUCTION: When performing open or laparoscopic nephroureterectomy (LNU), the optimal way to excise the distal ureter remains controversial. There are concerns that primary endoscopic detachment of the intramural ureter is associated with adverse outcomes. Existing studies have limited number of patients and inadequate oncologic follow-up. We provide our institutions experience of this technique. MATERIALS AND METHODS: Data were collected prospectively on 59 patients (37 men) who underwent LNU for a 10-year period at a single center using a standardized technique: initial endoscopic circumferential release of the distal ureter and bladder cuff followed by retroperitoneal en bloc LNU...
July 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28087299/when-partial-nephrectomy-is-unsuccessful-understanding-the-reasons-for-conversion-from-robotic-partial-to-radical-nephrectomy-at-a-tertiary-referral-center
#7
Önder Kara, Matthew J Maurice, Pascal Mouracade, Ercan Malkoç, Julien Dagenais, Ryan J Nelson, Jaya Sai S Chavali, Robert J Stein, Amr Fergany, Jihad H Kaouk
PURPOSE: We sought to identify the preoperative factors associated with conversion from robotic partial nephrectomy to radical nephrectomy. We report the incidence of this event. MATERIALS AND METHODS: Using our institutional review board approved database, we abstracted data on 1,023 robotic partial nephrectomies performed at our center between 2010 and 2015. Standard and converted cases were compared in terms of patients and tumor characteristics, and perioperative, functional and oncologic outcomes...
July 2017: Journal of Urology
https://www.readbyqxmd.com/read/27838412/metronomic-s-1-dosing-and-thymidylate-synthase-silencing-have-synergistic-antitumor-efficacy-in-a-colorectal-cancer-xenograft-model
#8
Amr S Abu Lila, Naoto Moriyoshi, Masakazu Fukushima, Cheng-Long Huang, Hiromi Wada, Tatsuhiro Ishida
Metronomic chemotherapy is currently considered an emerging therapeutic option in clinical oncology. S-1, an oral formulation of Tegafur (TF), a prodrug of 5-fluorouracil (5-FU), is designed to improve the antitumor activity of 5-FU in tandem with reducing its toxicity. Clinically, metronomic S-1 dosing has been approved for the standard first- and second-line treatment of metastatic or advanced stage of colorectal (CRC). However, expression of intratumor thymidylate synthase (TS), a significant gene in cellular proliferation, is associated with poor outcome to 5-FU-based chemotherapeutic regimens...
August 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/27600402/impact-of-serum-immunoglobulins-level-and-il-18-promoter-gene-polymorphism-among-egyptian-patients-with-idiopathic-thrombocytopenic-purpura
#9
Salah Aref, Mohamed Sabry El-Ghonemy, Sherin Abd El-Aziz, Tarek Abouzeid, Mona Talaab, Amr El-Sabbagh
OBJECTIVES: Based on the concept of immune dysregulation in immune thrombocytopenic purpura (ITP) and that Interleukin-18 (IL-18) is an inflammatory cytokine that plays an important role in autoimmune disease by inducing interferon-γ secretion; this study aimed to assess a possible association between the IL-18 promoter polymorphisms (-607 C/A site) and genetic susceptibility to ITP and the impact of the immunoglobulins (Igs) concentrations level on disease severity and response to therapy...
March 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27488479/oncological-outcomes-and-complication-rates-after-laparoscopic-assisted-cryoablation-a-european-registry-for-renal-cryoablation-eureca-multi-institutional-study
#10
MULTICENTER STUDY
Tommy K Nielsen, Brunolf W Lagerveld, Francis Keeley, Giovanni Lughezzani, Seshadri Sriprasad, Neil J Barber, Lars U Hansen, Nicole M Buffi, Giorgio Guazzoni, Johan A van der Zee, Mohamed Ismail, Khaled Farrag, Amr M Emara, Lars Lund, Øyvind Østraat, Michael Borre
OBJECTIVE: To assess complication rates and intermediate oncological outcomes of laparoscopic-assisted cryoablation (LCA) in patients with small renal masses (SRMs). PATIENTS AND METHODS: A retrospective review of 808 patients treated with LCA for T1a SRMs from 2005 to 2015 at eight European institutions. Complications were analysed according to the Clavien-Dindo classification. Kaplan-Meier analyses were used to estimate 5- and 10-year disease-free survival (DFS) and overall survival (OS)...
March 2017: BJU International
https://www.readbyqxmd.com/read/27072302/relationship-between-measures-of-adiposity-arterial-inflammation-and-subsequent-cardiovascular-events
#11
Amparo L Figueroa, Richard A P Takx, Megan H MacNabb, Amr Abdelbaky, Zachary R Lavender, Rebecca S Kaplan, Quynh A Truong, Janet Lo, Brian B Ghoshhajra, Steven K Grinspoon, Udo Hoffmann, Ahmed Tawakol
BACKGROUND: The objective of this study was to evaluate how different measures of adiposity are related to both arterial inflammation and the risk of subsequent cardiovascular events. METHODS AND RESULTS: We included individuals who underwent (18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging for oncological evaluation. Subcutaneous adipose tissue (SAT) volume, visceral adipose tissue (VAT) volume, and VAT/SAT ratio were determined...
April 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/26590477/designing-a-broad-spectrum-integrative-approach-for-cancer-prevention-and-treatment
#12
REVIEW
Keith I Block, Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei, A R M Ruhul Amin, Amr Amin, Katia Aquilano, Jack Arbiser, Alexandra Arreola, Alla Arzumanyan, S Salman Ashraf, Asfar S Azmi, Fabian Benencia, Dipita Bhakta, Alan Bilsland, Anupam Bishayee, Stacy W Blain, Penny B Block, Chandra S Boosani, Thomas E Carey, Amancio Carnero, Marianeve Carotenuto, Stephanie C Casey, Mrinmay Chakrabarti, Rupesh Chaturvedi, Georgia Zhuo Chen, Helen Chen, Sophie Chen, Yi Charlie Chen, Beom K Choi, Maria Rosa Ciriolo, Helen M Coley, Andrew R Collins, Marisa Connell, Sarah Crawford, Colleen S Curran, Charlotta Dabrosin, Giovanna Damia, Santanu Dasgupta, Ralph J DeBerardinis, William K Decker, Punita Dhawan, Anna Mae E Diehl, Jin-Tang Dong, Q Ping Dou, Janice E Drew, Eyad Elkord, Bassel El-Rayes, Mark A Feitelson, Dean W Felsher, Lynnette R Ferguson, Carmela Fimognari, Gary L Firestone, Christian Frezza, Hiromasa Fujii, Mark M Fuster, Daniele Generali, Alexandros G Georgakilas, Frank Gieseler, Michael Gilbertson, Michelle F Green, Brendan Grue, Gunjan Guha, Dorota Halicka, William G Helferich, Petr Heneberg, Patricia Hentosh, Matthew D Hirschey, Lorne J Hofseth, Randall F Holcombe, Kanya Honoki, Hsue-Yin Hsu, Gloria S Huang, Lasse D Jensen, Wen G Jiang, Lee W Jones, Phillip A Karpowicz, W Nicol Keith, Sid P Kerkar, Gazala N Khan, Mahin Khatami, Young H Ko, Omer Kucuk, Rob J Kulathinal, Nagi B Kumar, Byoung S Kwon, Anne Le, Michael A Lea, Ho-Young Lee, Terry Lichtor, Liang-Tzung Lin, Jason W Locasale, Bal L Lokeshwar, Valter D Longo, Costas A Lyssiotis, Karen L MacKenzie, Meenakshi Malhotra, Maria Marino, Maria L Martinez-Chantar, Ander Matheu, Christopher Maxwell, Eoin McDonnell, Alan K Meeker, Mahya Mehrmohamadi, Kapil Mehta, Gregory A Michelotti, Ramzi M Mohammad, Sulma I Mohammed, D James Morre, Vinayak Muralidhar, Irfana Muqbil, Michael P Murphy, Ganji Purnachandra Nagaraju, Rita Nahta, Elena Niccolai, Somaira Nowsheen, Carolina Panis, Francesco Pantano, Virginia R Parslow, Graham Pawelec, Peter L Pedersen, Brad Poore, Deepak Poudyal, Satya Prakash, Mark Prince, Lizzia Raffaghello, Jeffrey C Rathmell, W Kimryn Rathmell, Swapan K Ray, Jörg Reichrath, Sarallah Rezazadeh, Domenico Ribatti, Luigi Ricciardiello, R Brooks Robey, Francis Rodier, H P Vasantha Rupasinghe, Gian Luigi Russo, Elizabeth P Ryan, Abbas K Samadi, Isidro Sanchez-Garcia, Andrew J Sanders, Daniele Santini, Malancha Sarkar, Tetsuro Sasada, Neeraj K Saxena, Rodney E Shackelford, H M C Shantha Kumara, Dipali Sharma, Dong M Shin, David Sidransky, Markus David Siegelin, Emanuela Signori, Neetu Singh, Sharanya Sivanand, Daniel Sliva, Carl Smythe, Carmela Spagnuolo, Diana M Stafforini, John Stagg, Pochi R Subbarayan, Tabetha Sundin, Wamidh H Talib, Sarah K Thompson, Phuoc T Tran, Hendrik Ungefroren, Matthew G Vander Heiden, Vasundara Venkateswaran, Dass S Vinay, Panagiotis J Vlachostergios, Zongwei Wang, Kathryn E Wellen, Richard L Whelan, Eddy S Yang, Huanjie Yang, Xujuan Yang, Paul Yaswen, Clement Yedjou, Xin Yin, Jiyue Zhu, Massimo Zollo
Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted)...
December 2015: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/26558003/laparoscopic-radical-cystectomy
#13
REVIEW
Amr Fergany
OBJECTIVE: Laparoscopic radical cystectomy (LRC) has emerged as a minimally invasive alternative to open radical cystectomy (ORC). This review focuses on patient selection criteria, technical aspects and postoperative outcomes of LRC. METHODS: Material for the review was obtained by a PubMed search over the last 10 years, using the keywords 'laparoscopic radical cystectomy' and 'laparoscopic bladder cancer' in human subjects. RESULTS: Twenty-two publications selected for relevance and content were used for this review from the total search yield...
March 2012: Arab Journal of Urology
https://www.readbyqxmd.com/read/26434885/metformin-addition-to-chemotherapy-in-stage-iv-non-small-cell-lung-cancer-an-open-label-randomized-controlled-study
#14
RANDOMIZED CONTROLLED TRIAL
Rana Sayed, Amr S Saad, Lamia El Wakeel, Engi Elkholy, Osama Badary
PURPOSE: To evaluate effects of metformin on clinical outcome of non-diabetic patients with stage IV NSCLC. MATERIALS AND METHODS: A prospective, randomized, open-label, controlled pilot study was conducted on patients with stage IV NSCLC with an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0-2, excluding patients with diabetes and lactic acidosis. Thirty chemo-naive, non-diabetic patients with stage IV NSCLC were enrolled. Fifteen patients received intravenous gemcitabine/cisplatin regimen alone (arm B) while fifteen patients received the same regimen plus daily oral metformin 500 mg (arm A)...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26012710/survival-and-functional-stability-in-chronic-kidney-disease-due-to-surgical-removal-of-nephrons-importance-of-the-new-baseline-glomerular-filtration-rate
#15
Brian R Lane, Sevag Demirjian, Ithaar H Derweesh, Toshio Takagi, Zhiling Zhang, Lily Velet, Cesar E Ercole, Amr F Fergany, Steven C Campbell
BACKGROUND: Chronic kidney disease (CKD) can be associated with a higher risk of progression to end-stage renal disease and mortality, but the etiology of nephron loss may modify this. Previous studies suggested that CKD primarily due to surgical removal of nephrons (CKD-S) may be more stable and associated with better survival than CKD due to medical causes (CKD-M). OBJECTIVE: We addressed limitations of our previous work with comprehensive control for confounding factors, differentiation of non-renal cancer-related mortality, and longer follow-up for more discriminatory assessment of the impact of CKD-S...
December 2015: European Urology
https://www.readbyqxmd.com/read/25150130/the-pattern-of-infection-and-antibiotics-use-in-terminal-cancer-patients
#16
Amrallah A Mohammed, Abdullah S Al-Zahrani, Mohamed A Sherisher, Ahmad A Alnagar, Ayman El-Shentenawy, Amr T El-Kashif
BACKGROUND: Although cancer patients are susceptible to infection, there is no evidence-based published guideline on the appropriate use of antimicrobial treatment in this group of patients. METHODS: We retrospectively collected medical records of all terminal cancer patients who died in the oncology department over a 15-month period and were reviewed for the pattern of infection and causes of antimicrobial use during the patients' last admission of life. RESULTS: A total of 258 eligible patients were enrolled, there was an equal distribution of males and females (M/F: 129/129), and the mean age was 60...
September 2014: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/25108601/telomerase-reverse-transcriptase-tert-a1062t-mutation-as-a-prognostic-factor-in-egyptian-patients-with-acute-myeloid-leukemia-aml
#17
Salah Aref, Mohamed Sabry El-Ghonemy, Tarek Elsayed Abouzeid, Amr Mohamed El-Sabbagh, Mohamed Ali El-Baiomy
This study aimed to evaluate the incidence and clinical and prognostic impact of TERT A1062T mutation in AML patients treated at Mansoura Oncology Center. Screening for TERT A1062T mutation in exon 15 of the TERT gene was performed on diagnostic DNA samples from 153 AML patients and 197 healthy subjects as a control group by using sequence-specific primers. TERT A1062T mutation was detected in 18 cases out of 153 patients (11.8 %) and in one out of 197 control group subjects (0.51 %). The achievement of complete remission was significantly higher in AML group with wild type as compared to that in the mutant one (53...
September 2014: Medical Oncology
https://www.readbyqxmd.com/read/24530204/a-single-arm-confirmatory-study-of-amrubicin-therapy-in-patients-with-refractory-small-cell-lung-cancer-japan-clinical-oncology-group-study-jcog0901
#18
MULTICENTER STUDY
Haruyasu Murakami, Nobuyuki Yamamoto, Taro Shibata, Koji Takeda, Yukito Ichinose, Yuichiro Ohe, Noboru Yamamoto, Yuichiro Takeda, Shinzoh Kudoh, Shinji Atagi, Miyako Satouchi, Katsuyuki Kiura, Naoyuki Nogami, Masahiro Endo, Hirokazu Watanabe, Tomohide Tamura
OBJECTIVES: We conducted an open-label, multicenter, single-arm study to confirm the efficacy and safety of amrubicin (AMR), a topoisomerase II inhibitor, for treating refractory small-cell lung cancer (SCLC). PATIENTS AND METHODS: Patients with chemotherapy-refractory SCLC received 40 mg/m(2) AMR for 3 consecutive days, every 21 days. The primary endpoint was the overall response rate (ORR) and the secondary endpoints were progression-free survival (PFS), overall survival (OS), and safety...
April 2014: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/24468269/treatment-efficacy-and-tolerability-of-intravesical-bacillus-calmette-guerin-bcg-rivm-strain-induction-and-maintenance-protocol-in-high-grade-and-recurrent-low-grade-non-muscle-invasive-bladder-cancer-nmibc
#19
Naim B Farah, Rami Ghanem, Mahmoud Amr
BACKGROUND: BCG-RIVM strain was used in many treatment protocols for non-muscle invasive bladder cancer only as induction courses. Cho et al. (Anticancer Res 2012) compared BCG-RIVM induction and 'standard' maintenance (Lamm et al., J Urol. 2000) to mitomycin C. They found no statistically significant differences regarding disease recurrence and progression. The purpose of our study was to determine the efficacy & tolerability of this specific BCG RIVM strain, using six-weekly, induction course and single monthly instillations as maintenance for one year, in high risk recurrent, multifocal low grade and multifocal high grade pTa/pT1, CIS transitional cell carcinoma of bladder...
2014: BMC Urology
https://www.readbyqxmd.com/read/24053473/robot-assisted-partial-nephrectomy-vs-laparoscopic-cryoablation-for-the-small-renal-mass-redefining-the-minimally-invasive-gold-standard
#20
COMPARATIVE STUDY
Amr M Emara, Sashi S Kommu, Richard G Hindley, Neil J Barber
OBJECTIVE: To identify differences between the ablative and extirpative minimally invasive techniques of laparoscopic cryoablation (LC) and robot-assisted laparoscopic partial nephrectomy (RPN), respectively, in treating small renal tumours in terms of safety, peri-operative morbidity and early oncological outcomes. PATIENTS AND METHODS: Between June 2008 and April 2012 56 patients underwent LC and from October 2010 to April 2012, 47 patients underwent RPN using the Da Vinci robotic platform (Intuitive Surgical, Sunnyvale, CA, USA)...
January 2014: BJU International
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