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https://www.readbyqxmd.com/read/30534349/photobiomodulation-at-multiple-wavelengths-differentially-modulates-oxidative-stress-in-vitro-and-in-vivo
#1
Katia Rupel, Luisa Zupin, Andrea Colliva, Anselmo Kamada, Augusto Poropat, Giulia Ottaviani, Margherita Gobbo, Lidia Fanfoni, Rossella Gratton, Massimo Santoro, Roberto Di Lenarda, Matteo Biasotto, Serena Zacchigna
Photobiomodulation (PBM) is emerging as an effective strategy for the management of multiple inflammatory conditions, including oral mucositis (OM) in cancer patients who receive chemotherapy or radiotherapy. Still, the poor understanding of the mechanisms by which the light interacts with biological tissues and the heterogeneity of light sources and protocols employed worldwide significantly limits its applicability. Reactive oxygen species (ROS) are massively generated during the early phases of OM and play a major role in the pathogenesis of inflammation in general...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30533342/oh-radical-oxidation-of-lung-surfactant-protein-b-on-aqueous-surfaces
#2
Shinichi Enami, Agustín J Colussi
Air pollutants generate reactive oxygen species on lung surfaces. Here we report how hydroxyl radicals (·OH) injected on the surface of water react with SP-B1-25 , a 25-residue polypeptide surrogate of human lung surfactant protein B. Our experiments consist of intersecting microjets of aqueous SP-B1-25 solutions with O3 /O2 /H2 O/N2 (g) gas streams that are photolyzed into ·OH(g) in situ by 266 nm laser nanosecond pulses. Surface-sensitive mass spectrometry enables us to monitor the prompt (<10 μs) and simultaneous formation of primary O n -containing products/intermediates ( n ≤5) triggered by the reaction of ·OH with interfacial SP-B1-25 ...
2018: Mass Spectrometry
https://www.readbyqxmd.com/read/30525377/visible-light-responsive-photocatalyst-of-graphitic-carbon-nitride-for-pathogenic-biofilm-control
#3
Hongchen Shen, Enrique A López-Guerra, Ruochen Zhu, Tara Diba, Qinmin Zheng, Santiago De Jesus Solares, Jason Zara, Danmeng Shuai, Yun Shen
Pathogenic biofilms raise significant health and economic concerns, because these bacteria are persistent and can lead to long-term infections in vivo and surface contamination in healthcare and industrial facilities or devices. Compared with conventional antimicrobial strategies, photocatalysis holds promise for biofilm control because of its broad-spectrum effectiveness under ambient conditions, low cost, easy operation, and reduced maintenance. In this study, we investigated the performance and mechanism of Staphylococcus epidermidis biofilm control and eradication on the surface of an innovative photocatalyst, graphitic carbon nitride (g-C3N4), under visible light irradiation, which overcame the need for ultraviolet (UV) light for many current photocatalysts (e...
December 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30499655/near-infrared-irradiation-affects-lipid-metabolism-in-neuronal-cells-inducing-lipid-droplets-formation
#4
Svitlana M Levchenko, Andrey N Kuzmin, Tymish Y Ohulchanskyy, Artem Pliss, Junle Qu, Paras N Prasad
It is known that lipids play an outstanding role in cellular regulation and their dysfunction has been linked to many diseases. Thus, modulation of lipid metabolism may provide new pathways for disease treatment or prevention. In this work, near infrared (NIR) light was applied to modulate lipid metabolism, and increase intracellular lipid content in rat cortical neurons (RCN). Using label-free CARS microscopy, we have monitored the intracellular lipid content in RCN at a single cell level. A major increase in average level of lipid per cell after treatment with laser diode at 808 nm was found, nonlinearly dependent on the irradiation dose...
November 30, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/30483133/n-myristoylation-of-antimicrobial-peptide-cm4-enhances-its-anticancer-activity-by-interacting-with-cell-membrane-and-targeting-mitochondria-in-breast-cancer-cells
#5
Caiyun Li, Hongyan Liu, Yunqing Yang, Xixi Xu, Tongtong Lv, Huidan Zhang, Kehang Liu, Shuangquan Zhang, Yuqing Chen
Development of antimicrobial peptides (AMPs) as highly effective and selective anticancer agents would represent great progress in cancer treatment. Here we show that myristoyl-CM4, a new synthetic analog generated by N-myristoylation of AMPs CM4, had anticancer activity against MCF-7, MDA-MB-231, MX-1 breast cancer cells (IC50 of 3-6 μM) and MDA-MB-231 xenograft tumors. The improved activity was attributed to the effect of myristoyl on the cell membrane. Flow cytometry and confocal laser scanning microscopy results showed that N-myristoylation significantly increased the membrane affinity toward breast cancer cells and also effectively mediated cellular entry...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30474224/rational-design-of-ir820-and-ce6-based-versatile-micelle-for-single-nir-laser-induced-imaging-and-dual-modal-phototherapy
#6
Xu Hu, Hailong Tian, Wei Jiang, Aixin Song, Zhonghao Li, Yuxia Luan
Phototherapy as a promising cancer diagnostic and therapeutic strategy has aroused extensive attention. However, single-wavelength near-infrared (NIR) light-triggered combinational treatment of photothermal therapy (PTT) and photodynamic therapy (PDT) is still a great challenge. Herein, a multifunctional micelle activated by a single-wavelength laser for simultaneous PTT and PDT as well as fluorescence imaging is developed. Briefly, new indocyanine green (IR820) is conjugated to d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) via the linker 6-aminocaproic acid, and then, chlorin e6 (Ce6) is encapsulated into the micelles formed by TPGS-IR820 conjugates to fabricate TPGS-IR820/Ce6 micelles...
November 26, 2018: Small
https://www.readbyqxmd.com/read/30469455/a-handheld-real-time-photoacoustic-imaging-system-for-animal-neurological-disease-models-from-simulation-to-realization
#7
Yu-Hang Liu, Yu Xu, Lun-De Liao, Kim Chuan Chan, Nitish V Thakor
This article provides a guide to design and build a handheld, real-time photoacoustic (PA) imaging system from simulation to realization for animal neurological disease models. A pulsed laser and array-based ultrasound (US) platform were utilized to develop the system for evaluating vascular functions in rats with focal ischemia or subcutaneous tumors. To optimize the laser light delivery, finite element (FE)-based simulation models were developed to provide information regarding light propagation and PA wave generation in soft tissues...
November 21, 2018: Sensors
https://www.readbyqxmd.com/read/30468943/photocytotoxic-copper-ii-complexes-of-n-salicylyl-l-tryptophan-and-phenanthroline-bases
#8
Atrayee Banaspati, Dhananjay Das, Chandan J Choudhury, Arnab Bhattacharyya, Tridib K Goswami
Four ternary copper(II) complexes of N-salicylyl-l-Tryptophan (Sal-TrpH) and phenanthroline bases of general formula [Cu(Sal-Trp)(L)], where L is 1,10-phenanthroline (phen, 1), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq, 2), dipyrido[3,2-a:2',3'-c]phenazine (dppz, 3) and 2-(anthracen-1-yl)-1H-imidazo[4,5-f][1,10]phenanthroline (aip, 4), were synthesized and fully characterized. The complexes were evaluated for their affinity for biomolecules and photocytotoxic activities. Single crystal X-ray diffraction studies of complex 1 revealed that it has a square pyramidal CuN3 O2 core with the phenolate oxygen of salicylaldehyde occupying the axial coordination site in the solid state...
November 9, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30462481/ultrafast-x-ray-transient-absorption-spectroscopy-of-gas-phase-photochemical-reactions-a-new-universal-probe-of-photoinduced-molecular-dynamics
#9
Aditi Bhattacherjee, Stephen R Leone
Time-resolved spectroscopic investigations of light-induced chemical reactions with universal detection capitalize recently on single-photon molecular probing using laser pulses in the extreme ultraviolet or X-ray regimes. Direct and simultaneous mappings of the time-evolving populations of ground-state reactants, Franck-Condon (FC) and transition state regions, excited-state intermediates and conical intersections (CI), and photoproducts in photochemical reactions utilize probe pulses that are broadband and energy-tunable...
November 21, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/30457701/recent-advances-in-cell-membrane-camouflaged-nanoparticles-for-cancer-phototherapy
#10
REVIEW
Xu Zhen, Penghui Cheng, Kanyi Pu
Phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) employs phototherapeutic agents to generate heat or cytotoxic reactive oxygen species (ROS), and has therefore garnered particular interest for cancer therapy. However, the main challenges faced by conventional phototherapeutic agents include easy recognition by the immune system, rapid clearance from blood circulation, and low accumulation in target sites. Cell-membrane coating has emerged as a potential way to overcome these limitations, owing to the abundant proteins on the surface of cell membranes that can be inherited to the cell membrane-camouflaged nanoparticles...
November 20, 2018: Small
https://www.readbyqxmd.com/read/30453447/curcumin-loading-potentiates-the-neuroprotective-efficacy-of-fe-3-o-4-magnetic-nanoparticles-in-cerebellum-cells-of-schizophrenic-rats
#11
Parvaneh Naserzadeh, Asghar Ashrafi Hafez, Marjan Abdorahim, Mohammad Amin Abdollahifar, Ronak Shabani, Habiballah Peirovi, Abdolreza Simchi, Khadijeh Ashtari
BACKGROUND: The aim of this study was to investigate the neurotoxic effects of Fe3 O4 magnetic- CurNPs on isolated schizophrenia mitochondria of rats as an in vivo model. METHODS: We designed CMN loaded superparamagnetic iron oxide nanoparticles (SPIONs) (Fe3 O4 magnetic- CurNPs) to achieve an enhanced therapeutic effect. The physicochemical properties of Fe3 O4 magnetic- CurNPs were characterized using X-ray diffraction (XRD), and dynamic laser light scattering (DLS) and zeta potential...
December 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30453214/a-black-phosphorus-manganese-dioxide-nanoplatform-oxygen-self-supply-monitoring-photodynamic-therapy-enhancement-and-feedback
#12
Jintong Liu, Ping Du, Tianrui Liu, Bernardino J Córdova Wong, Weiping Wang, Huangxian Ju, Jianping Lei
Selecting the timing of laser treatment is an important task for improving O2 -dependent photodynamic therapy (PDT) efficiency. Here, a black phosphorus-based strategy was developed for dual-mode monitoring oxygen self-supply, enhancing photodynamic therapy, and feeding back therapeutic effect. The hybridized nanoplatform (R-MnO2 -FBP) was prepared by assembly of Rhodamine B (RhB)-encapsulated manganese dioxide (R-MnO2 ) as O2 supplier and indicator, and fluorescein isothiocyanate (FITC)-labelled peptide-functionalized black phosphorus as the theranostic agent...
October 17, 2018: Biomaterials
https://www.readbyqxmd.com/read/30448454/analysis-of-the-neuronal-network-of-the-medullary-respiratory-center-in-transgenic-rats-expressing-archaerhodopsin-3-in-phox2b-expressing-cells
#13
Keiko Ikeda, Ryosuke Kaneko, Yuchio Yanagawa, Masaaki Ogawa, Kazuto Kobayashi, Satoru Arata, Kiyoshi Kawakami, Hiroshi Onimaru
Preinspiratory (Pre-I) neurons in the parafacial respiratory group (pFRG) comprise one of the respiratory rhythm generators in the medulla of the neonatal rat. A subgroup of pFRG/Pre-I neurons expresses the transcription factor Phox2b. To further analyze detailed neuronal mechanisms of respiratory rhythm generation in the neonatal rat, we developed a transgenic (Tg) rat line in which Phox2b-positive cells expressed archaerhodopsin-3 (Arch). Brainstem-spinal cord preparations were isolated from 0-2-day-old Tg newborn rats and were superfused with artificial cerebrospinal fluid equilibrated with 95% O2 and 5% CO2 , pH 7...
November 15, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/30427859/differences-in-sperm-protein-abundance-and-carbonylation-level-in-bull-ejaculates-of-low-and-high-quality
#14
Agnieszka Mostek, Błażej Westfalewicz, Mariola Słowińska, Mariola Aleksandra Dietrich, Sylwia Judycka, Andrzej Ciereszko
In breeding and insemination centres, significant variation in bull ejaculate quality is often observed between individuals and also within the same individual. Low-quality semen does not qualify for cryopreservation and is rejected, generating economic loss. The mechanisms underlying the formation of low-quality ejaculates are poorly understood; therefore, the aim of the present study was to investigate the proteomic differences and oxidative modifications (measured as changes in protein carbonylation level) of bull ejaculates of low and high quality...
2018: PloS One
https://www.readbyqxmd.com/read/30374407/disintegration-of-simulated-drinking-water-biofilms-with-arrays-of-microchannel-plasma-jets
#15
Peter P Sun, Elbashir M Araud, Conghui Huang, Yun Shen, Guillermo L Monroy, Shengyun Zhong, Zikang Tong, Stephen A Boppart, J Gary Eden, Thanh H Nguyen
Biofilms exist and thrive within drinking water distribution networks, and can present human health concerns. Exposure of simulated drinking water biofilms, grown from groundwater, to a 9 × 9 array of microchannel plasma jets has the effect of severely eroding the biofilm and deactivating the organisms they harbor. In-situ measurements of biofilm structure and thickness with an optical coherence tomography (OCT) system show the biofilm thickness to fall from 122 ± 17 µm to 55 ± 13 µm after 15 min...
2018: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/30368078/photo-enhanced-singlet-oxygen-generation-of-prussian-blue-based-nanocatalyst-for-augmented-photodynamic-therapy
#16
Dongdong Wang, Ruohong Shi, Jiajia Zhou, Sixiang Shi, Huihui Wu, Pengping Xu, Hui Wang, Guoliang Xia, Todd E Barnhart, Weibo Cai, Zhen Guo, Qianwang Chen
Therapeutic effects of photodynamic therapy (PDT) remain largely limited because of tumor hypoxia. Herein, we report safe and versatile nanocatalysts (NCs) for endogenous oxygen generation and imaging-guided enhanced PDT. The NCs (named as PSP) are prepared by coating Prussian blue (PB) with mesoporous silica to load photosensitizer (zinc phthalocyanine, ZnPc), followed by the modification of polyethylene glycol chains. The inner PB not only acts like a catalase for hydrogen peroxide decomposition but also serves as a photothermal agent to increase the local temperature and then speed up the oxygen supply under near-infrared irradiation...
October 12, 2018: iScience
https://www.readbyqxmd.com/read/30362706/cyclomatrix-polyphosphazene-porous-networks-with-j-aggregated-multiphthalocyanine-arrays-for-dual-modality-near-infrared-photosensitizers
#17
Jing Tan, Jittima Meeprasert, Yuxue Ding, Supawadee Namuangruk, Xuesong Ding, Changchun Wang, Jia Guo
Here, we have developed a kind of cyclomatrix polyphosphazene with excellent photophysical properties and pursued their potential of being organic photosensitizers for dual-modality phototherapy. Briefly, hexachlorocyclophosphazene (HCCP) with D3 h symmetry is adopted as a synthon to attach Zn(II) phthalocyanine (ZnPc) to form dendritic units that are covalently expanded into a soluble porous network through the nucleophilic substitution reaction. Molecular simulation reveals that the multi-ZnPc units around HCCP can be oriented in a side-by-side manner, leading to the remarkably red-shifted and intense absorbance in the near-infrared (NIR) region...
November 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30358991/rapid-acceleration-of-hydrogen-atom-abstraction-reactions-of-oh-at-very-low-temperatures-through-weakly-bound-complexes-and-tunneling
#18
Dwayne E Heard
A generally accepted principle of chemical kinetics is that a reaction will be very slow at low temperatures if there is an activation barrier on the potential energy surface to form products. However, this Account shows that the reverse is true for gas-phase hydrogen abstraction reactions of the hydroxyl radical, OH, with organic molecules with which it can form a weakly bound (5-30 kJ mol-1 ) hydrogen-bonded complex. For hydrogen atom abstraction reactions of OH with volatile organic compounds (VOCs) containing alcohol, ether, carbonyl, and ester functional groups, the reaction accelerates rapidly at very low temperatures, with rate coefficients, k, that can be up to a 1000 times faster than those at room temperature, despite the barrier to products...
October 25, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/30349943/metalloporphyrin-indomethacin-conjugates-as-new-photosensitizers-for-photodynamic-therapy
#19
Fengshou Wu, Mengqian Yang, Juan Zhang, Sizhe Zhu, Mengge Shi, Kai Wang
Photodynamic therapy (PDT) is a promising cancer treatment approach with the advantages of low toxicity and noninvasive characteristics. In this study, a series of metalloporphyrin-indomethacin conjugates tethered with poly(ethylene glycol) (PEG) chains were prepared and characterized. The singlet oxygen production of the conjugates was evaluated through 2', 7'-dichlorofluorescin (DCFH) method. Because of the heavy atom effect, the metal porphyrin complexes exhibited the higher singlet oxygen (1 O2 ) quantum yield than that of free base porphyrin...
October 22, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/30349077/recruitment-of-lc3-to-damaged-golgi-apparatus
#20
Lígia C Gomes-da-Silva, Ana Joaquina Jimenez, Allan Sauvat, Wei Xie, Sylvie Souquere, Séverine Divoux, Marko Storch, Baldur Sveinbjørnsson, Øystein Rekdal, Luis G Arnaut, Oliver Kepp, Guido Kroemer, Franck Perez
LC3 is a protein that can associate with autophagosomes, autolysosomes, and phagosomes. Here, we show that LC3 can also redistribute toward the damaged Golgi apparatus where it clusters with SQSTM1/p62 and lysosomes. This organelle-specific relocation, which did not involve the generation of double-membraned autophagosomes, could be observed after Golgi damage was induced by various strategies, namely (i) laser-induced localized cellular damage, (ii) local expression of peroxidase and exposure to peroxide and diaminobenzidine, (iii) treatment with the Golgi-tropic photosensitizer redaporfin and light, (iv) or exposure to the Golgi-tropic anticancer peptidomimetic LTX-401...
October 22, 2018: Cell Death and Differentiation
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