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https://www.readbyqxmd.com/read/30328457/photosensitiser-functionalised-luminescent-upconverting-nanoparticles-for-efficient-photodynamic-therapy-of-breast-cancer-cells
#1
Markus Buchner, Paula García Calavia, Verena Muhr, Anna Kröninger, Antje J Baeumner, Thomas Hirsch, David A Russell, María J Marín
Photodynamic therapy (PDT) is a well-established treatment of cancer in which cell toxic reactive oxygen species, including singlet oxygen (1O2), are produced by a photosensitiser drug following irradiation of a specific wavelength. Visible light is commonly used as the excitation source in PDT, although these wavelengths do have limited tissue penetration. In this research, upconverting nanoparticles (UCNPs) functionalised with the photosensitiser Rose Bengal (RB) have been designed and synthesised for PDT of breast cancer cells...
October 17, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/30316904/sharp-ph-sensitive-amphiphilic-polypeptide-macrophotosensitizer-for-near-infrared-imaging-guided-photodynamic-therapy
#2
Pan Yuan, Zheng Ruan, Tuanwei Li, Youliang Tian, Quan Cheng, Lifeng Yan
Tumor environmental sensitive polypeptide integrated photosensitizers is a platform for imaging-guided photodynamic therapy (PDT). However, the photosensitizer leakage during blood circulation, poor accumulation in tumor tissue and inferior quantum yield of singlet oxygen are still challenges. Herein, NHS-active boron-dipyrromethene derivative with bromine substituted NHS-BODIPY-Br2 was first synthesized, which possessed high singlet oxygen generation efficiency and near infrared (NIR) fluorescence, and then it was conjugated to a sharp pH (6...
October 11, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/30315526/catalpol-inhibits-homocysteine-induced-oxidation-and-inflammation-via-inhibiting-nox4-nf-%C3%AE%C2%BAb-and-grp78-perk-pathways-in-human-aorta-endothelial-cells
#3
Huimin Hu, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhihao Liu, Kexin Liu, Xiaoyu Liu, Huijun Sun
Hyperhomocysteinemia (HHCY) has been recognized as an independent risk factor for atherosclerosis and plays a vital role in the development of atherosclerosis. Catalpol, an iridoid glucoside extracted from the root of Rehmannia glutinosa, can produce anti-inflammatory, anti-oxidant, anti-tumor, and dopaminergic neurons protecting effects. This study aimed to determine the protecting effects of catalpol against homocysteine (HCY)-induced injuries in human aortic endothelial cells (HAECs) and uncover the underlying mechanisms: 1...
October 12, 2018: Inflammation
https://www.readbyqxmd.com/read/30306153/fluorinated-polymeric-micelles-to-overcome-hypoxia-and-enhance-photodynamic-cancer-therapy
#4
Qian Wang, Jia-Mi Li, Hui Yu, Kai Deng, Wei Zhou, Cai-Xia Wang, Yang Zhang, Kun-Heng Li, Ren-Xi Zhuo, Shi-Wen Huang
Photodynamic therapy (PDT) as an alternative choice of cancer treatment method has attracted increasing attention in the past few decades. A sufficient amount of oxygen is essential for the production of singlet oxygen (1O2) in successful PDT; however, hypoxia is a typical hallmark of cancer, which is one of the most important limitation factors of PDT. To overcome the hypoxic tumour microenvironment and achieve highly efficient photodynamic cancer therapy, herein, a photosensitizer Ce6-loaded fluorinated polymeric micelle (Ce6-PFOC-PEI-M) was constructed via the self-assembly of an amphiphilic polymer prepared from perfluorooctanoic acid and branched polyethyleneimine (10 kDa)...
October 11, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/30300749/trimodal-synergistic-antitumor-drug-delivery-system-based-on-graphene-oxide
#5
Xuwu Zhang, Liyao Luo, Lei Li, Yuchu He, Weiwei Cao, Huan Liu, Kang Niu, Dawei Gao
A multifunctional antitumor drug delivery system was synthesized based on graphene oxide (GO) for near-infrared (NIR) light controlling chemotherapeutic/photothermal (PTT) /photodynamic (PDT) trimodal synergistic therapy. The system named ICG-Wed-GO was formed by co-loading wedelolactone (Wed) and indocyanine green (ICG) on the surface of GO through π-π stacking interaction. Under NIR laser irradiation, ICG-Wed-GO could effectively absorb and transform optical energy to heat, generate reactive oxygen species (ROS) to ablating and damage tumor cells...
October 6, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/30286411/analysis-of-microvascular-blood-flow-and-oxygenation-discrimination-between-two-haemodynamic-steady-states-using-nonlinear-measures-and-multiscale-analysis
#6
Marjola Thanaj, Andrew J Chipperfield, Geraldine F Clough
OBJECTIVE: This study investigates the feasibility of the use of nonlinear complexity methods as a tool to identify altered microvascular function often associated with pathological conditions. We evaluate the efficacy of multiscale nonlinear complexity methods to account for the multiple time-scales of processes modulating microvascular network perfusion. METHODS: Microvascular blood flux (BF) and oxygenation (OXY: oxyHb, deoxyHb, totalHb and SO2 %) signals were recorded simultaneously at the same site, from the skin of 15 healthy young male volunteers using combined laser Doppler fluximetry (LDF) and white light spectroscopy...
September 26, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/30277589/2-deoxy-d-glucose-augments-photodynamic-therapy-induced-mitochondrial-caspase-independent-apoptosis-and-energy-mediated-autophagy
#7
Xiaolan Feng, Yin Shi, Lifen Xie, Kun Zhang, Xiaobing Wang, Quanhong Liu, Pan Wang
OBJECTIVES: Compared to normal cells, malignant cells have a high degree of aerobic glycolysis, also known as the Warburg effect. Therefore, supplementing photodynamic therapy (PDT), an established cancer therapy, with metabolic inhibitors can augment the mitochondrial damage by depleting ATP. To assess the combined impact of the glycolysis inhibitor 2-deoxy-D-glucose (2-DG) and PDT on apoptosis and autophagy in human breast cancer cells, and examine the molecular basis. METHODS: Calcium-AM/PI double staining was used to evaluate cell viability...
September 17, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/30275968/clinical-development-of-photodynamic-agents-and-therapeutic-applications
#8
REVIEW
Rengarajan Baskaran, Junghan Lee, Su-Geun Yang
Background: Photodynamic therapy (PDT) is photo-treatment of malignant or benign diseases using photosensitizing agents, light, and oxygen which generates cytotoxic reactive oxygens and induces tumour regressions. Several photodynamic treatments have been extensively studied and the photosensitizers (PS) are key to their biological efficacy, while laser and oxygen allow to appropriate and flexible delivery for treatment of diseases. Introduction: In presence of oxygen and the specific light triggering, PS is activated from its ground state into an excited singlet state, generates reactive oxygen species (ROS) and induces apoptosis of cancer tissues...
2018: Biomaterials Research
https://www.readbyqxmd.com/read/30256439/dihydroartemisinin-increases-gemcitabine-therapeutic-efficacy-in-ovarian-cancer-by-inducing-reactive-oxygen-species
#9
Shengcai Yang, Dawei Zhang, Na Shen, Guanyi Wang, Zhaohui Tang, Xuesi Chen
Ovarian cancer is the major cause of death in women gynecological malignancy and gemcitabine (GEM) is commonly used in related chemotherapy. However, more than 90% GEM is catalyzed into an inactive metabolite 2'-deoxy-2',2'-difluorouridine by stromal and cellular cytidine deaminase (CDA). Dihydroartemisinin (DHA), which possesses an intramolecular endoperoxide bridge, could be activated by heme or ferrous iron to produce reactive oxygen species (ROS). The excess ROS generation will excite expression of heme oxygenase-1 and suppress CDA expression...
September 6, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30254654/how-does-the-sweet-violet-viola-odorata-l-fight-pathogens-and-pests-cyclotides-as-a-comprehensive-plant-host-defense-system
#10
Blazej Slazak, Małgorzata Kapusta, Adam A Strömstedt, Aneta Słomka, Marta Krychowiak, Mohammadreza Shariatgorji, Per E Andrén, Jerzy Bohdanowicz, Elżbieta Kuta, Ulf Göransson
Cyclotides are cyclic plant polypeptides of 27-37 amino acid residues. They have been extensively studied in bioengineering and drug development contexts. However, less is known about the relevance of cyclotides for the plants producing them. The anti-insect larvae effects of kB1 and antibacterial activity of cyO2 suggest that cyclotides are a part of plant host defense. The sweet violet ( Viola odorata L.) produces a wide array of cyclotides, including kB1 (kalata B1) and cyO2 (cycloviolacin O2), with distinct presumed biological roles...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/30250463/contribution-of-fluorescence-techniques-in-determining-the-efficiency-of-the-non-thermal-plasma-treatment
#11
Gaëlle Carré, Emilie Charpentier, Sandra Audonnet, Christine Terryn, Mohamed Boudifa, Christelle Doliwa, Zouhaier Ben Belgacem, Sophie C Gangloff, Marie-Paule Gelle
We have recently developed a non-thermal plasma (NTP) equipment intended to sterilize fragile medical devices and maintain the sterile state of items downstream the treatment. With traditional counts on agar plate a six log reduction of Staphylococcus aureus viability was obtained within 120 min of O2 , Ar, or N2 NTP treatments. However to determine the best NTP process, we studied the different physiological states of S. aureus by flow cytometry (FC) and confocal laser scanning microscopy (CLSM) focusing on the esterasic activity and membrane integrity of the bacteria...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30248969/electromagnetic%C3%A2-acoustic-sensing-for-biomedical-applications
#12
REVIEW
Siyu Liu, Ruochong Zhang, Zesheng Zheng, Yuanjin Zheng
This paper reviews the theories and applications of electromagnetic⁻acoustic (EMA) techniques (covering light-induced photoacoustic, microwave-induced thermoacoustic, magnetic-modulated thermoacoustic, and X-ray-induced thermoacoustic) belonging to the more general area of electromagnetic (EM) hybrid techniques. The theories cover excitation of high-power EM field (laser, microwave, magnetic field, and X-ray) and subsequent acoustic wave generation. The applications of EMA methods include structural imaging, blood flowmetry, thermometry, dosimetry for radiation therapy, hemoglobin oxygen saturation (SO₂) sensing, fingerprint imaging and sensing, glucose sensing, pH sensing, etc...
September 21, 2018: Sensors
https://www.readbyqxmd.com/read/30246053/nonlinear-photoacoustic-imaging-by-in-situ-multiphoton-upconversion-and-energy-transfer
#13
Depeng Wang, Wei Wei, Ajay Singh, Guang S He, Ramamurthi Kannan, Loon-Seng Tan, Guanying Chen, Paras N Prasad, Jun Xia
In recent years, photoacoustic tomography (PAT) is increasingly used in biomedical research, as it allows for direct visualization of optical absorption in deep tissue. In addition to vascular and hemodynamic imaging using endogenous contrasts, PAT is also capable of imaging neural and molecular dynamics with extrinsic contrasts. While near-infrared (NIR)-absorbing contrasts are preferred for deep tissue imaging, compared to visible-light-absorbing contrasts, they are much harder to design and synthesize with good environmental stability...
November 15, 2017: ACS Photonics
https://www.readbyqxmd.com/read/30216761/effect-of-red-light-and-near-infrared-laser-on-the-generation-of-reactive-oxygen-species-in-primary-dermal-fibroblasts
#14
Sajan George, Michael R Hamblin, Heidi Abrahamse
Irradiation with red light or near-infrared (NIR) lasers can bio-modulate cellular processes or revitalize injured tissues and therefore, widely been used for therapeutic interventions. Mechanistically, this cellular or biological process, referred as Photobiomodulation (PBM), is achieved by the generation of oxide free radicals in cells and tissues. This explorative study using red light (636 nm) and Near Infra-Red (NIR, 825 nm) laser at various irradiation exposures reckons the level of oxidative stress induced by these free radicals in human primary fibroblasts...
November 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/30186981/influence-of-pharmacological-preconditioning-on-the-results-of-lifting-operations-efficiency
#15
N E Manturova, V A Stupin, G O Smirnova, E V Silina
The main aim of the study is to determine the effectiveness and safety of lifting operations in women with varying degrees of involuntary changes of facial skin, in particular when applying pharmacological conditioning, with the objectification of the role of the latter. Materials and methods: A research and surgical treatment were conducted to eliminate involutional changes of various degrees in the facial skin of 461 women aged 35-75 years. Surface lifting was performed in 20.2% of patients, SMAS-lifting - 49...
August 2018: Heliyon
https://www.readbyqxmd.com/read/30171977/a-tumor-targeted-near-infrared-light-controlled-nanocomposite-to-combat-with-multidrug-resistance-of-cancer
#16
Meng Wang, Jiahe Wu, Ying Li, Fangyuan Li, Xi Hu, Gang Wang, Min Han, Daishun Ling, Jianqing Gao
Stimuli-responsive nanomaterials have emerged as promising drug delivery systems for tumor therapy, as they can specifically respond to tumor-associated stimuli and release the loaded drugs in a controllable manner. However, most currently available stimuli-responsive nanomedicines rely on surrounding extreme stimulus to trigger the activity, which can be inefficient under dynamic and complex living conditions. Herein, we report a near-infrared (NIR) light-responsive nanocomposite, which can generate reactive oxygen species to efficiently trigger the decomposition upon NIR laser irradiation...
October 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30147831/h-2-o-2-signaling-triggered-pi3k-mediates-mitochondrial-protection-to-participate-in-early-cardioprotection-by-exercise-preconditioning
#17
Yang Yuan, Shan-Shan Pan, Dong-Feng Wan, Jiao Lu, Yue Huang
Previous studies have shown that early exercise preconditioning (EEP) imparts a protective effect on acute cardiovascular stress. However, how mitophagy participates in exercise preconditioning- (EP-) induced cardioprotection remains unclear. EEP may involve mitochondrial protection, which presumably crosstalks with predominant H2 O2 oxidative stress. Our EEP protocol involves four periods of 10 min running with 10 min recovery intervals. We added a period of exhaustive running and a pretreatment using phosphoinositide 3-kinase (PI3K)/autophagy inhibitor wortmannin to test this protective effect...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30144532/improved-singlet-oxygen-generation-and-antimicrobial-activity-of-sulphur-doped-graphene-quantum-dots-coupled-with-methylene-blue-for-photodynamic-therapy-applications
#18
Khomidkhodza Kholikov, Saidjafarzoda Ilhom, Muhammed Sajjad, Michael E Smith, Jerry D Monroe, Omer San, Ali Oguz Er
Due to their many unique properties, graphene quantum dots (GQDs) have attracted much attention and are a promising material with potential applications in many fields. One application of GQDs is as a photodynamic therapy agent that generates singlet oxygen. In this work, GQDs were grown by focusing nanosecond laser pulses into benzene and then were later combined with methylene blue (MB) and used to eradicate the Gram-negative bacteria, Escherichia coli, and Gram-positive bacteria, Micrococcus luteus. Theoretical calculation of pressure evolution was calculated using the standard finite difference method...
August 22, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/30142531/2-pyridone-functionalized-aza-bodipy-photosensitizer-for-imaging-guided-sustainable-phototherapy
#19
Wanyue Xiao, Peng Wang, Changjin Ou, Xiaoyu Huang, Yunyun Tang, Meiyan Wu, Weili Si, Jinjun Shao, Wei Huang, Xiaochen Dong
To overcome irradiation-dependence of cancer phototherapy, a near infrared aza-BODIPY-based photothermogenic photosensitizer BDY with 2-Pyridone group has been synthesized for imaging-guided photothermal synergistic sustainable photodynamic therapy. Multifunctional water-soluble BDY nanoparticles (NPs), with high photothermal conversion efficiency of 35.7% and excellent singlet oxygen (1 O2 ) generation ability, are prepared by self-assembling. The reversible transformation between 2-pyridone moiety and its endoperoxide form endows BDY with continuous 1 O2 generation ability under illumination and non-illumination conditions...
August 18, 2018: Biomaterials
https://www.readbyqxmd.com/read/30133835/highly-efficient-photosensitizers-with-far-red-near-infrared-aggregation-induced-emission-for-in-vitro-and-in-vivo-cancer-theranostics
#20
Dong Wang, Michelle M S Lee, Guogang Shan, Ryan T K Kwok, Jacky W Y Lam, Huifang Su, Yuchen Cai, Ben Zhong Tang
Fluorescence-imaging-guided photodynamic therapy has emerged as a promising protocol for cancer theranostics. However, facile preparation of such a theranostic material for simultaneously achieving bright emission with long wavelength, high-performance reactive oxygen species (ROS) generation, and good targeting-specificity of cancer cells, is highly desirable but remains challenging. In this study, a novel type of far-red/near-infrared-emissive fluorescent molecules with aggregation-induced emission (AIE) characteristics is synthesized through a few steps reaction...
August 22, 2018: Advanced Materials
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