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Haemostasis

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https://www.readbyqxmd.com/read/28942686/fibrin-glue-for-local-haemostasis-in-haemophilia-surgery
#1
E Carlos Rodriguez-Merchan
INTRODUCTION: Local fibrin glue (FG) appears to be a useful local haemostatic agent for severe haemorrhage in people with haemophilia (PWH) undergoing surgical procedures. AIM: To evaluate the role of local FG in PWH. METHODS: A review of the literature on the topic has been performed. RESULTS: Local FG is not always necessary to achieve haemostasis in all surgical procedures performed in PWH. However, it could be a good adjunct therapy, primarily when a surgical field will bleed more than expected (e...
September 23, 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/28938703/evaluation-of-thromboelastometry-parameters-as-predictive-markers-for-sinusoidal-obstruction-syndrome-in-patients-undergoing-allogeneic-stem-cell-transplantation-for-acute-leukaemia
#2
Joanna Rupa-Matysek, Lidia Gil, Ewelina Wojtasińska, Zuzanna Kanduła, Adam Nowicki, Magdalena Matuszak, Mieczysław Komarnicki
Hepatic sinusoidal obstruction syndrome (previously named veno-occlusive disease, SOS/VOD) is a serious complication of allogeneic stem cell transplantation (HSCT). Early identification of patients at risk of SOS/VOD may possibly improve the outcome and reduce mortality. Rotation thromboelastometry (ROTEM) is global assay allowing for the precise assessment of both bleeding and thrombotic conditions, however, its usefulness in patients undergoing HSCT for acute leukaemia has not been studied. We evaluated the thromboelastometry parameters in patients undergoing allogeneic HSCT for acute leukaemia to identify candidate biomarkers of SOS/VOD occurrence...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28936089/rescue-measure-in-giant-intracranial-meningioma-resection-by-tranexamic-acid
#3
H Raghavendra, K S Varsha, M Arun Reddy, Samsun Sujith Kumar, G Sunanda, T Nagarjuna, Swarna Latha
Neurosurgeons may find themselves in a precarious situation, while unable to secure haemostasis following tumour resection. We report intraoperative use of tranexamic acid to secure complete haemostasis as rescue measure in intracranial meningioma resection in uncontrollable bleeding.
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28931364/plasminogen-activator-inhibitor-type-1-a-possible-novel-biomarker-of-late-pituitary-dysfunction-after-mild-traumatic-brain-injury
#4
Istvan Frendl, Monika Katko, Erika Galgoczi, Judit Boda, Noemi Zsiros, Zoltan Nemeti, Zsuzsanna Bereczky, Renata Hudak, Janos Kappelmayer, Annamaria Erdei, Bela Turchanyi, Endre V Nagy
More than 80% of head trauma patients suffer from mild traumatic brain injury (mTBI). However, even mTBI carries the risk of late pituitary dysfunction. A predictive biomarker at the time of injury which could identify patients who subsequently may develop permanent pituitary dysfunction would help to direct patients towards endocrine care. We enrolled 508 traumatic brain injury patients (406 with mTBI) into our study. Blood samples were collected for identification of predictive biomarkers of late pituitary dysfunction at the time of admission...
September 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28928330/emergency-hand-assisted-laparoscopic-haemostasis-for-post-operative-haemorrhage-following-laparoscopic-liver-resection
#5
Tze Yi Low, Brian Kim Poh Goh
INTRODUCTION: The use of laparoscopic surgery for liver resection and the management of abdominal emergencies has been well established. However, the value of this technique for post-operative haemorrhage in liver resection has not been characterized. CASE DESCRIPTION: We describe a case of post-operative haemorrhage following an elective totally laparoscopic liver resection that was treated with emergency hand-assisted laparoscopic haemostasis. DISCUSSION: Emergency hand-assisted laparoscopic haemostasis in the setting of post-operative haemorrhage after laparoscopic liver resection is feasible and should be considered as a treatment option in suitable patients...
September 20, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28921533/dental-treatment-in-the-era-of-new-anti-thrombotic-agents
#6
REVIEW
Sharonit Sahar-Helft, Tali Chackartchi, David Polak, Mordechai Findler
BACKGROUND: In recent years, there have been dramatic changes in anti-thrombotic treatment as a result of new anti-thrombotic agents, as well as changes in the indications for their use. As a consequence, dentists are encountering larger numbers of patients who are undergoing anti-thrombotic treatment and who have increased risk for bleeding. The current paper aims to review the literature regarding up-to-date anti-thrombotic treatment and provide information regarding their implications on dentistry...
September 17, 2017: International Dental Journal
https://www.readbyqxmd.com/read/28917882/a-review-about-brown-algal-cell-walls-and-fucose-containing-sulfated-polysaccharides-cell-wall-context-biomedical-properties-and-key-research-challenges
#7
REVIEW
Estelle Deniaud-Bouët, Kevin Hardouin, Philippe Potin, Bernard Kloareg, Cécile Hervé
Studies on brown algal cell walls have entered a new phase with the concomitant discovery of novel polysaccharides present in cell walls and the establishment of a comprehensive generic model for cell wall architecture. Brown algal cell walls are composites of structurally complex polysaccharides. In this review we discuss the most recent progress in the structural composition of brown algal cell walls, emphasizing the significance of extraction and screening techniques, and the biological activities of the corresponding polysaccharides, with a specific focus on the fucose-containing sulfated polysaccharides...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28911288/impact-of-thrombelastography-in-paediatric-intensive-care
#8
B G Carter, E Carland, P Monagle, S B Horton, W Butt
We assessed the clinical impact of thrombelastography (TEG®) results (TEG® 5000, Haemonetics Corporation, Braintree, MA, USA) by measuring their ability to cause changes in a theoretical treatment plan and contribute to the understanding of haemostasis. We prospectively included paediatric intensive care unit (PICU) patients who had standard tests of haemostasis and TEG ordered and had an arterial catheter or extracorporeal access port in situ. Blood for standard tests and TEG was taken simultaneously. Independent of patient care, general patient information and results of standard laboratory tests were presented to five clinicians who were asked to document their theoretical treatment plan...
September 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28902830/-use-of-tachocomb-agent-in-cardiovascular-surgery
#9
I M Ignat'ev, S V Moiseev
The article contains a review of the literature concerning the use of the Tachocomb haemostatic sponge in cardiovascular surgery. This is followed by enumerating the pharmacological properties of the agent, mechanism of its action, and methods of application. Also shown herein is a high haemostatic effect of the sponge, exceeding that of other means of topical haemostasis. Both safety and a hypoallergenic nature make it possible to widely use Tachocomb in surgical practice.
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28892657/evaluation-of-dabigatran-rivaroxaban-and-apixaban-target-specific-assays-in-a-multicenter-french-study
#10
Isabelle Gouin-Thibault, Geneviève Freyburger, Emmanuel de Maistre, Sophie Susen, Xavier Delavenne, Jean-Louis Golmard, Yves Gruel, Pierre Sié
Dabigatran etexilate, rivaroxaban and apixaban (DOACs) are widely used and measurement of their concentration is desirable in certain clinical situations. Target-specific assays are available but limited information exists on their performance especially in their ability to accurately measure low and high concentrations. AIMS: To define, in a multicenter study, the precision and accuracy of DOAC measurements in daily practice. METHODS: 15 plasma samples (kindly provided by Hyphen-Biomed) spiked with 5 blinded concentrations of dabigatran, rivaroxaban or apixaban (targeted 0-40-100-250-500ng/mL, actual concentrations measured by HPLC-MS/MS), were sent to 30 haemostasis laboratories...
September 4, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28876572/haemoperitoneum-secondary-to-snake-bite
#11
S Rahim
BACKGROUND: Literature supports that very rarely the venom of "Hemotoxic Snake" (Russell's Vipers) affect haemostasis by secreting thrombin-like enzyme which promotes formation of unstable clots. Such clots could lead to fibrin deposition in micro circulation that in turn consume platelets and coagulation factors (consumption coagulopathy). Clinical presentation is mainly spontaneous bleeding and coagulopathy. In this case the significant effects of altered coagulation were observed in retropetitoneum and the patient presented in casuality as acute abdomen...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28866697/haematological-parameters-and-screening-tests-of-haemostasis-in-children-with-sepsis-results-from-a-tertiary-care-centre-in-india
#12
A Sharma, M Sikka, H Bhankar, S Gomber, S Sharma
Sepsis is a common cause of death in infants and children. Haemostatic abnormalities have been reported in such patients. There is scant information on the nature and frequency of these abnormalities in children especially from India. Our aim was to evaluate the nature and frequency of haematological and haemostatic abnormalities in children with sepsis. Fifty children between 1-10 years of age admitted with sepsis and 50 age-matched, healthy controls were included in the study. Complete blood counts, examination of stained peripheral blood film, prothrombin time (PT), activated partial thromboplastin time (APTT), plasma fibrinogen, C-reactive protein, liver function tests and serum creatinine were done in all patients and controls...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28863803/xxvi-congress-of-the-international-society-on-thrombosis-and-haemostasis
#13
Lan-Lan Smith
No abstract text is available yet for this article.
September 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28860991/antithrombotic-potential-of-tormentil-extract-in-animal-models
#14
Natalia Marcinczyk, Dominika Jarmoc, Agnieszka Leszczynska, Agnieszka Zakrzeska, Karol Kramkowski, Jakub Strawa, Anna Gromotowicz-Poplawska, Ewa Chabielska, Michal Tomczyk
Potentilla species that have been investigated so far display pharmacological activity mainly due to the presence of polyphenols. Recently, it was shown that polyphenol-rich extract from rhizome of Potentilla erecta (tormentil extract) affects the metabolism of arachidonic acid and exerts both anti-inflammatory and anti-oxidant activities, suggesting a possible effect on thrombosis. Accordingly, the aim of the study was to evaluate the effect of tormentil extract on haemostasis in a rat model of thrombosis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28858685/laparoscopy-during-pregnancy-case-report-and-key-points-to-improve-laparoscopic-management
#15
REVIEW
Josep Estadella, Pia Español, Beatriz Grandal, Marta Gine, Juan Parra
A 34-year-old woman in her 19th week of gestation was admitted to the Emergency Department of our hospital for acute abdominal pain. The patient was diagnosed with haemoperitoneum. Laparoscopy was performed and revealed acute bleeding from a crumbly superficial uterine vascular network. Haemostasis was achieved and both mother and foetus recovered well after surgery. A caesarean section was performed at 38 weeks, delivering a healthy newborn and revealing that the pregnancy had developed in a rudimentary hemiuterus...
August 18, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28858246/thirty-minutes-of-hypobaric-hypoxia-provokes-alterations-of-immune-response-haemostasis-and-metabolism-proteins-in-human-serum
#16
Jochen Hinkelbein, Stefanie Jansen, Ivan Iovino, Silvia Kruse, Moritz Meyer, Fabrizio Cirillo, Hendrik Drinhaus, Andreas Hohn, Corinna Klein, Edoardo De Robertis, Dirk Beutner
Hypobaric hypoxia (HH) during airline travel induces several (patho-) physiological reactions in the human body. Whereas severe hypoxia is investigated thoroughly, very little is known about effects of moderate or short-term hypoxia, e.g. during airline flights. The aim of the present study was to analyse changes in serum protein expression and activation of signalling cascades in human volunteers staying for 30 min in a simulated altitude equivalent to airline travel. After approval of the local ethics committee, 10 participants were exposed to moderate hypoxia (simulation of 2400 m or 8000 ft for 30 min) in a hypobaric pressure chamber...
August 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28857634/antiplatelets-and-profibrinolytic-activity-of-citrullus-colocynthis-in-control-and-high-fat-diet-induced-obese-rats-mechanisms-of-action
#17
Naif M Alhawiti
The current study aimed to investigate the effect of Citrullus colocynthis (C. colocynthis) hydro-alcoholic extract on blood haemostasis in control and high-fat diet (HFD) induced obese rats. In control rats, the extract significantly enhanced bleeding time and plasma levels of tPA and significantly decreased plasma levels PAI-1 and serum levels of thromboxane B2 leading to inhibition of platelets aggregation. In HFD induced obese rats, similar effects were seen and the extract was also able to reverse HFD induced increases in fibrinogen and VWF...
August 31, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28852291/effectiveness-of-fibrin-glue-in-adherence-of-skin-graft
#18
Konda Sireesha Reddy, Ravi Kumar Chittoria, Preethitha Babu, Senthil Kumaran Marimuthu, Sudhanva Hemanth Kumar, Elan Kumar Subbarayan, Vinayak Chavan, Devi Prasad Mohapatra, Dinesh Kumar Sivakumar, M T Friji
BACKGROUND: Graft fixation is important for graft take. Fibrin glue has been proposed as an ideal material, because of its human origin and it provides firm adhesion in seconds or minutes. OBJECTIVE: To evaluate the efficiency of fibrin glue, in increasing the take of skin graft. Assessment includes surgical time taken for graft fixation, haematoma/seroma formation, engraftment and wound closure by day 14. METHODS: The study is an observational prospective study conducted in the Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, from January 2016 to June 2016...
April 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28843665/balanced-haemostasis-with-both-hypo-and-hyper-coagulable-features-in-critically-ill-patients-with-acute-on-chronic-liver-failure
#19
Caleb Fisher, Vishal C Patel, Sidsel Hyldgaard Stoy, Arjuna Singanayagam, Jelle Adelmeijer, Julia Wendon, Debbie L Shawcross, Ton Lisman, William Bernal
BACKGROUND: Cirrhotic patients have complex haemostatic abnormalities. Current evidence suggests stable cirrhotic (SC) patients have a "re-balanced" haemostatic state. However, limited data exists in acute decompensated (AD) or acute on chronic liver failure (ACLF) patients. METHODS: We utilised thrombin generation analysis, fibrinolysis assessment, and evaluation of haemostatic parameters to assess haemostasis in liver disease of progressive severity. RESULTS: The study cohorts were comprised of: SC, n=8; AD n=44; ACLF, n=17; and Healthy Control (HC), n=35...
August 17, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28842055/standardisation-of-polypectomy-technique
#20
REVIEW
Alan Moss, Kumanan Nalankilli
There are several approaches to polypectomy for sessile polyps <20 mm and for pedunculated polyps. Recent evidence is leading towards standardisation of polypectomy technique. Key recent polypectomy developments include: 1. Use of cold snare polypectomy (CSP) for sessile polyps <10 mm; 2. Use of hot snare polypectomy (HSP) following submucosal injection for sessile polyps sized 10-19 mm; 3. Piecemeal cold snare polypectomy (PCSP), with or without prior submucosal injection, for select sessile polyps sized 10-19 mm, where the potential risk for an adverse event is increased (e...
August 2017: Best Practice & Research. Clinical Gastroenterology
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