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https://www.readbyqxmd.com/read/30243295/triamcinolone-acetonide-affects-tgf-%C3%AE-signaling-regulation-of-fibrosis-in-idiopathic-carpal-tunnel-syndrome
#1
Tai-Hua Yang, Anne Gingery, Andrew R Thoreson, Dirk R Larson, Chunfeng Zhao, Peter C Amadio
BACKGROUND: Fibroblast behavior and cell-matrix interactions of cells from normal and idiopathic carpal tunnel syndrome (CTS) subsynovial connective tissue (SSCT) with and without Triamcinolone Acetonide (TA) were compared in this study. A cell-seeded gel contraction model was applied to investigate the effect of steroid treatment on SSCT fibroblast gene expression and function. METHODS: SSCT cells were obtained from CTS patients and fresh cadavers. Cells were isolated by mechanical and collagenase digestion...
September 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30242176/new-transgenic-nis-reporter-rats-for-longitudinal-tracking-of-fibrogenesis-by-high-resolution-imaging
#2
Bethany Brunton, Lukkana Suksanpaisan, Hongtao Li, Qian Liu, Yinxian Yu, Alyssa Vrieze, Lianwen Zhang, Nathan Jenks, Huailei Jiang, Timothy R DeGrado, Chunfeng Zhao, Stephen J Russell, Kah-Whye Peng
Fibrogenesis is the underlying mechanism of wound healing and repair. Animal models that enable longitudinal monitoring of fibrogenesis are needed to improve traditional tissue analysis post-mortem. Here, we generated transgenic reporter rats expressing the sodium iodide symporter (NIS) driven by the rat collagen type-1 alpha-1 (Col1α1) promoter and demonstrated that fibrogenesis can be visualized over time using SPECT or PET imaging following activation of NIS expression by rotator cuff (RC) injury. Radiotracer uptake was first detected in and around the injury site day 3 following surgery, increasing through day 7-14, and declining by day 21, revealing for the first time, the kinetics of Col1α1 promoter activity in situ...
September 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30228241/treatment-of-human-glioblastoma-with-a-live-attenuated-zika-virus-vaccine-candidate
#3
Qi Chen, Jin Wu, Qing Ye, Feng Ma, Qian Zhu, Yan Wu, Chao Shan, Xuping Xie, Dapei Li, Xiaoyan Zhan, Chunfeng Li, Xiao-Feng Li, Xiaoling Qin, Tongyang Zhao, Haitao Wu, Pei-Yong Shi, Jianghong Man, Cheng-Feng Qin
Glioblastoma (GBM) is the deadliest type of brain tumor, and glioma stem cells (GSCs) contribute to tumor recurrence and therapeutic resistance. Thus, an oncolytic virus targeting GSCs may be useful for improving GBM treatment. Because Zika virus (ZIKV) has an oncolytic tropism for infecting GSCs, we investigated the safety and efficacy of a live attenuated ZIKV vaccine candidate (ZIKV-LAV) for the treatment of human GBM in a GSC-derived orthotopic model. Intracerebral injection of ZIKV-LAV into mice caused no neurological symptoms or behavioral abnormalities...
September 18, 2018: MBio
https://www.readbyqxmd.com/read/30211918/first-principles-study-of-anion-diffusion-in-lead-free-halide-double-perovskites
#4
Chunfeng Lan, Shuai Zhao, Jingting Luo, Ping Fan
Halide ion diffusion in organolead halide perovskites has raised great concern in recent years and been considered as the reason for the hysteresis of current-voltage curves and degradation of perovskite solar cells. In this work, X-site halide ion diffusion in lead-free double perovskites Cs2 AgBiX6 (X = Cl, Br), Cs2 AgSbCl6 and Cs2 AgInCl6 is investigated by first-principles calculations. The formation energies of X-site vacancies are calculated for these double perovskites, and predicted to be related to the electronic configurations of B-site cations...
October 7, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29993698/drpocs-drug-repositioning-based-on-projection-onto-convex-sets
#5
Yin-Ying Wang, Chunfeng Cui, Liqun Qi, Hong Yan, Xingming Zhao
Drug repositioning, i.e. identifying new indications for known drugs, has attracted a lot of attentions recently and is becoming an effective strategy in drug development. In literature, several computational approaches have been proposed to identify potential indications of old drugs based on various types of data sources. In this paper, by formulating the drug-disease associations as a low-rank matrix, we propose a novel method, namely DrPOCS, to identify candidate indications of old drugs based on projection onto convex sets (POCS)...
April 26, 2018: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/29988514/adjunct-rasagiline-to-treat-parkinson-s-disease-with-motor-fluctuations-a-randomized-double-blind-study-in-china
#6
Zhenxin Zhang, Ming Shao, Shengdi Chen, Chunfeng Liu, Rong Peng, Yansheng Li, Jian Wang, Suiqiang Zhu, Qiumin Qu, Xiaoying Zhang, Haibo Chen, Xiangru Sun, Yanping Wang, Shenggang Sun, Baorong Zhang, Jimei Li, Xiaoping Pan, Gang Zhao
Background: The use of adjunct rasagiline in levodopa-treated patients with Parkinson's disease and motor fluctuations is supported by findings from large-scale clinical studies. This study is to investigate the efficacy and safety of adjunct rasagiline in Chinese patients with Parkinson's disease, as a product registration study. Methods: This 16-week, randomized, double-blind, parallel-group, multicenter, placebo-controlled study of rasagiline 1 mg/day included levodopa-treated patients with Parkinson's disease and motor fluctuations...
2018: Translational Neurodegeneration
https://www.readbyqxmd.com/read/29977306/isolation-and-characterization-of-multipotent-turkey-tendon-derived-stem-cells
#7
Qian Liu, Yaxi Zhu, Peter C Amadio, Steven L Moran, Anne Gingery, Chunfeng Zhao
Tendon injuries are among the most common and severe hand injuries with a high demand for functional recovery. Stem cells have been identified and isolated from different species and a variety of tissues for the sake of regenerative medicine. Recently, turkey has been suggested as a potential new large animal model for flexor tendon-related research. However, turkey tissue-specific stem cells have not been investigated. Here, we presented the isolation and verification of tendon-derived stem cells (TDSCs) from 6- to 8-month-old heritage-breed turkey...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29935733/the-effects-of-lyophilization-on-flexural-stiffness-of-extrasynovial-and-intrasynovial-tendon
#8
Chun Bi, Andrew R Thoreson, Chunfeng Zhao
Tendon or ligament reconstructions often use autologous or allogenic tendons from either extrasynovial or intrasynovial sources. Allograft tendons must be lyophilized for preservation before transplantation, a process which can impact mechanical properties of the graft. Reconstituted graft properties that are similar to native tendon are desirable. Although tensile and compressive properties of tendons have been investigated, there is a paucity of information describing flexural properties of tendon, which can impact the gliding resistance...
June 18, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29933719/fibrin-glue-as-an-alternative-to-peripheral-sutures-does-not-increase-tendon-repair-strength-in-an-in-vitro-model
#9
Kosuke Uehara, Chunfeng Zhao, Peter C Amadio
No abstract text is available yet for this article.
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29921658/-parp12-suppresses-zika-virus-infection-through-parp-dependent-degradation-of-ns1-and-ns3-viral-proteins
#10
Lili Li, Hui Zhao, Ping Liu, Chunfeng Li, Natalie Quanquin, Xue Ji, Nina Sun, Peishuang Du, Cheng-Feng Qin, Ning Lu, Genhong Cheng
Zika virus infection stimulates a type I interferon (IFN) response in host cells, which suppresses viral replication. Type I IFNs exert antiviral effects by inducing the expression of hundreds of IFN-stimulated genes (ISGs). To screen for antiviral ISGs that restricted Zika virus replication, we individually knocked out 21 ISGs in A549 lung cancer cells and identified PARP12 as a strong inhibitor of Zika virus replication. Our findings suggest that PARP12 mediated the ADP-ribosylation of NS1 and NS3, nonstructural viral proteins that are involved in viral replication and modulating host defense responses...
June 19, 2018: Science Signaling
https://www.readbyqxmd.com/read/29763517/novel-engineered-tendon-fibrocartilage-bone-composite-with-cyclic-tension-for-rotator-cuff-repair
#11
Qian Liu, Taku Hatta, Jun Qi, Haoyu Liu, Andrew R Thoreson, Peter C Amadio, Steven L Moran, Scott P Steinmann, Anne Gingery, Chunfeng Zhao
Surgical repair of rotator cuff tears presents a significant clinical challenge with high failure rates and inferior functional outcomes. Graft augmentation improves repair outcomes; however, currently available grafting materials have limitations. Although cell-seeded decellularized tendon slices may facilitate cell infiltration, promote tendon incorporation, and preserve original mechanical strength, the unique fibrocartilage zone is yet to be successfully reestablished. In this study, we investigated the biological and mechanical properties of an engineered tendon-fibrocartilage-bone composite (TFBC) with cyclic tension (3% strain; 0...
July 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29731324/comparison-of-two-ways-of-altering-carpal-tunnel-pressure-with-ultrasound-surface-wave-elastography
#12
Yu-Shiuan Cheng, Boran Zhou, Kazutoshi Kubo, Kai-Nan An, Steven L Moran, Peter C Amadio, Xiaoming Zhang, Chunfeng Zhao
Higher carpal tunnel pressure is related to the development of carpal tunnel syndrome. Currently, the measurement of carpal tunnel pressure is invasive and therefore, a noninvasive technique is needed. We previously demonstrated that speed of wave propagation through a tendon in the carpal tunnel measured by ultrasound elastography could be used as an indicator of carpal tunnel pressure in a cadaveric model, in which a balloon had to be inserted into the carpal tunnel to adjust the carpal tunnel pressure. However, the method for adjusting the carpal tunnel pressure in the cadaveric model is not applicable for the in vivo model...
June 6, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29709668/facile-green-synthetic-graphene-based-co-fe-prussian-blue-analogues-as-an-activator-of-peroxymonosulfate-for-the-degradation-of-levofloxacin-hydrochloride
#13
Yunqing Pi, Lingjia Ma, Peng Zhao, Yangdan Cao, Huiqin Gao, Chunfeng Wang, Qilu Li, Shuying Dong, Jianhui Sun
A kind of Co-Fe Prussian blue analogues (Co-Fe PBAs), cobalt hexacyanoferrate Co3 [Fe(CN)6 ]2 , and graphene oxide (GO) were combined to synthesize magnetically separable Co-Fe PBAs@rGO nanocomposites through a simple two-step hydrothermal method. The crystalline structure, morphology and textural properties of the Co-Fe PBAs@rGO nanocomposites were characterized. The catalytic performance of the nanocomposites was evaluated by PMS activation, with Levofloxacin Hydrochloride (LVF) as the target contaminant...
September 15, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29660539/oxidation-of-acetone-over-co-based-catalysts-derived-from-hierarchical-layer-hydrotalcite-influence-of-co-al-molar-ratios-and-calcination-temperatures
#14
Qian Zhao, Yunli Ge, Kaixuan Fu, Na Ji, Chunfeng Song, Qingling Liu
In order to enhance catalytic performance for acetone, Co-based catalysts prepared under different Co/Al molar ratios and calcination temperatures have been studied in this work. The results indicated that the catalytic activities of the catalysts firstly increased and then decreased with the increase of the Co/Al molar ratio and decreased with the increase of the calcination temperature. Based on the catalytic activities, TG/DTA, XRD, TPR and XPS characterization results, it can be found that catalytic activities of the catalysts with various Co/Al molar ratios were effected by the good crystallization structure of catalyst precursor, surface Co3+ /Co2+ molar ratio, low temperature reducibility, and Oads /Olatt molar ratio of the catalysts...
August 2018: Chemosphere
https://www.readbyqxmd.com/read/29613931/comparison-of-autograft-and-allograft-with-surface-modification-for-flexor-tendon-reconstruction-a-canine-in-vivo-model
#15
Zhuang Wei, Ramona L Reisdorf, Andrew R Thoreson, Gregory D Jay, Steven L Moran, Kai-Nan An, Peter C Amadio, Chunfeng Zhao
BACKGROUND: Flexor tendon injury is common, and tendon reconstruction is indicated clinically if the primary repair fails or cannot be performed immediately after tendon injury. The purpose of the current study was to compare clinically standard extrasynovial autologous graft (EAG) tendon and intrasynovial allogeneic graft (IAG) that had both undergone biolubricant surface modification in a canine in vivo model. METHODS: Twenty-four flexor digitorum profundus (FDP) tendons from the second and fifth digits of 12 dogs were used for this study...
April 4, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29603350/establishment-of-an-in-vivo-turkey-model-for-the-study-of-flexor-tendon-repair
#16
Assaf Kadar, Haoyu Liu, Alyssa M Vrieze, Thomas R Meier, Andrew R Thoreson, Peter C Amadio, Steven L Moran, Chunfeng Zhao
Flexor tendon injuries are common and pose a clinical challenge for functional restoration. The purpose of our study was to assess the adequacy of the turkey as a large animal model for flexor tendon injuries in vivo. Twenty-four male turkeys underwent surgical flexor tendon cut and repair. Turkeys were allocated to five groups postoperatively: (1) foot casted in extension and sacrificed after 3 weeks; (2) foot casted in extension and sacrificed after 6 weeks; (3) foot casted in flexion and sacrificed after 3 weeks; (4) foot casted in flexion and sacrificed after 6 weeks; and (5) foot casted in flexion for 6 weeks and then free roaming allowed for an additional 3 weeks before sacrifice...
September 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29575268/revitalized-and-synovialized-allograft-for-intrasynovial-flexor-tendon-reconstruction-in-an-in-vivo-canine-model
#17
Tao Zhang, Cheng-Chang Lu, Ramona L Reisdorf, Andrew R Thoreson, Anne Gingery, Steven L Moran, Peter C Amadio, Chunfeng Zhao
This study was to test our hypothesis that flexor tendon reconstruction with an allograft revitalized with bone marrow stromal cells (BMSCs) and synovialized with carbodiimide derivatized autologous synovial fluid (cd-SYN) would result in better digit functional restoration than the conventional allograft tendon. A total of 32 flexor digital profundus tendons from the second and fifth digit of 16 dogs were created a repair failure model first. Then, failed-repaired tendons were reconstructed with either a revitalized-synovialized allograft tendon or a clinical standard autograft tendon (control group)...
March 25, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29542129/simultaneous-determination-of-diethylacetal-and-acetaldehyde-during-beer-fermentation-and-storage-process
#18
Chunfeng Liu, Qi Li, Chengtuo Niu, Feiyun Zheng, Yun Zhao
BACKGROUND: Acetaldehyde is an important flavor component in beer which is possibly carcinogenic to humans. Owing to the limitations of present detection methods, only free-state acetaldehyde in beers has been focused on, while acetal in beers has hardly been reported so far. RESULTS: A sensitive headspace gas chromatography method was developed for the determination of diethylacetal and acetaldehyde in beer. The column DB-23 was chosen with a total run time of 22...
September 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29521436/microrna-320-involves-in-the-cardioprotective-effect-of-insulin-against-myocardial-ischemia-by-targeting-survivin
#19
Ni Yang, Liuzhong Wu, Ying Zhao, Ning Zou, Chunfeng Liu
It is generally accepted that insulin exerts an antiapoptotic effect against ischemia/reperfusion through the activation of PI3K/Akt/mTOR pathway. MicroRNAs involve in multiple cardiac pathophysiological processes, including ischemia/reperfusion-induced cardiac injury. However, the regulation of microRNAs in the cardioprotective effect of insulin is rarely discussed. In this study, using a cell model of ischemia through culturing H9C2 cardiac myocytes in serum-free medium with hypoxia, we demonstrated that pretreatment with insulin significantly inhibited cell apoptosis and downregulated microRNA-320 (miR-320) expression...
April 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29507686/mitochondrial-oxidative-stress-activates-cox-2-mpges-1-pge2-cascade-induced-by-albumin-in-renal-proximal-tubular-cells
#20
Yibo Zhuang, Chenhu Wang, Chunfeng Wu, Dan Ding, Fei Zhao, Caiyu Hu, Wei Gong, Guixia Ding, Yue Zhang, Lihong Chen, Guangrui Yang, Chunhua Zhu, Aihua Zhang, Zhanjun Jia, Songming Huang
COX-2/mPGES-1/PGE2 cascade is of importance in the pathogenesis of kidney injury. Meanwhile, recent studies documented a detrimental role of mitochondrial oxidative stress in kidney diseases. The present study was undertaken to investigate the role of mitochondrial oxidative stress in albumin-induced activation of COX-2/mPGES-1/PGE2 cascade in renal proximal tubular cells. Following albumin overload in mice, we observed a significant increase of oxidative stress and mitochondrial abnormality determined by transmission electron microscope, which was attenuated by the administration of MnTBAP, a mitochondrial SOD2 mimic...
February 6, 2018: Oncotarget
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