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Urinary bladder cancers

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https://www.readbyqxmd.com/read/30535715/novel-nomograms-to-predict-recurrence-and-progression-in-primary-non-muscle-invasive-bladder-cancer-validation-of-predictive-efficacy-in-comparison-with-european-organization-of-research-and-treatment-of-cancer-scoring-system
#1
Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
PURPOSE: To develop and validate novel nomograms to predict recurrence and progression after transurethral resection of bladder tumor (TURBT) in Korean patients with non-muscle-invasive bladder cancer (NMIBC). METHODS: We retrospectively analyzed the clinical data on 970 newly diagnosed NMIBC patients after TURBT between 2000 and 2013 in a single institution. We used multivariate Cox proportional hazard models to identify the significant predictors of recurrence and progression, which resulted in the construction of the nomograms predicting the 5-year probability of recurrence and progression...
December 10, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/30535713/rab38-promotes-bladder-cancer-growth-by-promoting-cell-proliferation-and-motility
#2
Da-Wei Tian, Sheng-Lai Liu, Li-Ming Jiang, Zhou-Liang Wu, Jie Gao, Hai-Long Hu, Chang-Li Wu
BACKGROUND: Bladder cancer is the most common malignancy of urinary system with high morbidity and mortality. In general, the development and progression of bladder cancer are complicated pathological processes, and the treatment methods mainly include surgical resection, radiotherapy, chemotherapy, and combined therapy. In recent years, targeted therapy has made progress in the treatment of bladder cancer. Therefore, to improve survival rates of patients with advanced bladder cancer, novel therapeutic targets are still urgently needed...
December 10, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/30534816/bipolar-en-bloc-tumor-resection-versus-standard-monopolar-turbt-which-is-the-best-way-to-go-in-non-invasive-bladder-cancer
#3
Georgiana Xenia Bălan, Petrişor Aurelian Geavlete, Dragoş Adrian Georgescu, Cosmin Victor Ene, Cătălin Andrei Bulai, Maria Alexandra Păunescu, Andrei Niculae, Ileana Peride, Ioan Lascăr, Tiberiu Paul Neagu, Bogdan Florin Geavlete
The aim of the study was to observe similarities and differences regarding surgical safety and prognosis between en bloc bipolar resection and monopolar transurethral resection of bladder tumors (TURBTs) in medium size papillary non-muscle invasive bladder tumors (NMIBTs). A total of 90 patients with papillary bladder tumors presenting a diameter between 1 and 3 cm were equally divided and alternatively assigned for en bloc bipolar ablation (the study group) and conventional TURBT (the control group). During one year, every three months, the follow-up was performed and the protocol included urinary cytology and cystoscopy...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/30533316/identification-of-key-candidate-genes-and-biological-pathways-in-bladder-cancer
#4
Xin Gao, Yinyi Chen, Mei Chen, Shunlan Wang, Xiaohong Wen, Shufang Zhang
Background: Bladder cancer is a malignant tumor in the urinary system with high mortality and recurrence rates. However, the causes and recurrence mechanism of bladder cancer are not fully understood. In this study, we used integrated bioinformatics to screen for key genes associated with the development of bladder cancer and reveal their potential molecular mechanisms. Methods: The GSE7476, GSE13507, GSE37815 and GSE65635 expression profiles were downloaded from the Gene Expression Omnibus database, and these datasets contain 304 tissue samples, including 81 normal bladder tissue samples and 223 bladder cancer samples...
2018: PeerJ
https://www.readbyqxmd.com/read/30530582/long-term-urinary-tract-effect-of-ileal-conduit-after-radical-cystectomy-compared-with-bladder-preservation-a-nationwide-population-based-cohort-study-with-propensity-score-matching-analysis
#5
Yu Liang Liu, Hao-Lun Luo, Po-Huang Chiang, Yen-Chen Chang, Po-Hui Chiang
OBJECTIVE: Ileal conduit urinary diversion (ICUD) is the most common procedure after radical cystectomy. Although complications have been reported, few patients with ICUD and bladder preservation controls have been available for long-term follow-up. This study compared the long-term effect of structural changes after cystectomy with ICUD to that in bladder preservation controls. DESIGN: A retrospective nationwide cohort study. SETTING: Data retrieved from the Taiwan National Health Insurance Research Database...
December 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/30528938/evaluation-of-tert-promoter-mutations-in-urinary-cell-free-dna-and-sediment-dna-for-detection-of-bladder-cancer
#6
Sebastian Stasik, Karsten Salomo, Ulrike Heberling, Michael Froehner, Ulrich Sommer, Gustavo B Baretton, Gerhard Ehninger, Manfred P Wirth, Christian Thiede, Susanne Fuessel
BACKGROUND: Cell-free DNA (cfDNA) is proposed to be a valuable source of biomarkers in liquid biopsies for various diseases as it is supposed to partially originate from tumor cells. However, data about the diagnostic implications of cfDNA in urine for the detection of bladder cancer (BCa) is sparse. METHODS: We evaluated the usability of urinary cfDNA for diagnostic purposes compared to urine sediment DNA (sDNA) in 53 BCa patients and 36 control subjects by analyzing two abundant point-mutations (C228T/C250T) in the TERT promoter using Next-Generation Sequencing...
December 4, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/30526165/human-papillomavirus-and-squamous-cell-carcinoma-of-the-urinary-bladder-dablaca-10-study
#7
Kit Riegels Jørgensen, Søren Høyer, Jakob Kristian Jakobsen, Thor Knak Jensen, Niels Marcussen, Gitte Wrist Lam, Thomas Hasselager, Peter Ole Thind, Birgitte Grønkær Toft, Torben Steiniche, Jørgen Bjerggaard Jensen
OBJECTIVE: To evaluate a potential association between Human Papillomavirus (H.P.V.) and squamous cell carcinoma (S.C.C.) urinary bladder cancer (B.C.). Furthermore, the relation between p16INK4a, H.P.V. and B.C. was examined. PATIENTS AND METHODS: Patients were included and divided into three groups based on the histological diagnosis of B.C. SPECIMENS: An extensive exclusion was performed, including accepted casual risk factors for S.C.C...
December 11, 2018: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/30523608/silodosin-an-update-on-efficacy-safety-and-clinical-indications-in-urology
#8
REVIEW
Luca Villa, Paolo Capogrosso, Umberto Capitanio, Alberto Martini, Alberto Briganti, Andrea Salonia, Francesco Montorsi
INTRODUCTION: Silodosin determines smooth muscle relaxation in bladder and prostate tissues, increases bladder blood flow in conditions of chronic bladder ischemia and regulates the activity of transcriptional factors responsible for stromal growth and prostate hyperplasia. Phase III trials have already demonstrated the efficacy and safety of silodosin in the treatment of patients bothered by lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). OBJECTIVE: We aimed to describe the rationality for the use of silodosin and to summarize the current literature on the use of Silodosin for the treatment of LUTS...
December 6, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/30523435/biodistribution-pharmacokinetics-and-organ-level-dosimetry-for-188-re-ahdd-lipiodol-radioembolization-based-on-quantitative-post-treatment-spect-ct-scans
#9
Pedro L Esquinas, Ajit Shinto, Koramadai K Kamaleshwaran, Jephy Joseph, Anna Celler
BACKGROUND: Rhenium-188-labelled-Lipiodol radioembolization is a safe and cost-effective treatment for primary liver cancer. In order to determine correlations between treatment doses and patient response to therapy, accurate patient-specific dosimetry is required. Up to date, the reported dosimetry of 188 Re-Lipiodol has been based on whole-body (WB) planar imaging only, which has limited quantitative accuracy. The aim of the present study is to determine the in vivo pharmacokinetics, bio-distribution, and organ-level dosimetry of 188 Re-AHDD-Lipiodol radioembolization using a combination of post-treatment planar and quantitative SPECT/CT images...
December 7, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/30522445/electromotive-drug-administration-emda-of-mitomycin-c-as-first-line-salvage-therapy-in-high-risk-bcg-failure-non-muscle-invasive-bladder-cancer-3-years-follow-up-outcomes
#10
Marco Racioppi, Luca Di Gianfrancesco, Mauro Ragonese, Giuseppe Palermo, Emilio Sacco, Pier Francesco Bassi
BACKGROUND: In case of high grade non-muscle invasive bladder cancer (HG-NMIBC), intravesical BCG represents the first-line treatment; despite the "gold" standard therapy, up to 50% of patients relapse, needing radical cystectomy. Hence, alternative therapeutic strategies have been developed. The aim of the study was to evaluate a first-line salvage treatment with EMDA®-MMC in patients with HGNMIBC unresponsive to BCG. METHODS: We carried out a prospective, single-center, single-arm Phase II study in order to evaluate the efficacy (in terms of recurrence and progression) and the safety of the EMDA®-MMC treatment in 26 (21 male, 5 female) consecutive patients with "BCG refractory" HGNMIBC on a 3 years follow-up...
December 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30514109/understanding-physical-activity-behavior-in-patients-with-bladder-cancer-before-and-after-radical-cystectomy-a-qualitative-interview-study
#11
Elke Rammant, Valérie Fonteyne, Karel Decaestecker, Renée Bultijnck, Benedicte Deforche, Ronny Pieters, Piet Ost, Sofie Verhaeghe, Ann Van Hecke
OBJECTIVE: To explore the determinants of physical activity in patients with bladder cancer before and after radical cystectomy. DESIGN: A qualitative research design using semi-structured face-to-face interviews. SETTING AND SUBJECTS: A total of 30 interviews were conducted with people diagnosed with bladder cancer and treated with radical cystectomy at Ghent University Hospital. MAIN MEASURES: The interviews were audiotaped and transcribed verbatim...
December 4, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/30513851/ubc-%C3%A2-rapid-test-a-urinary-point-of-care-poc-assay-for-diagnosis-of-bladder-cancer-with-a-focus-on-non-muscle-invasive-high-grade-tumors-results-of-a-multicenter-study
#12
Thorsten H Ecke, Sarah Weiß, Carsten Stephan, Steffen Hallmann, Christian Arndt, Dimitri Barski, Thomas Otto, Holger Gerullis
OBJECTIVES: UBC® Rapid Test measures soluble fragments of cytokeratins 8 and 18 in urine. We present results of a multicenter study using an updated version of UBC® Rapid Test in bladder cancer patients, patients with urinary bladder cancer positive history, and healthy controls. MATERIAL AND METHODS: In total 530 urine samples have been included in this study. Clinical urine samples were used from 242 patients with tumors of the urinary bladder (134 non-muscle-invasive low-grade tumors (NMI-LG), 48 non-muscle-invasive high-grade tumors (NMI-HG), and 60 muscle-invasive high-grade tumors (MI-HG)), 62 patients with non-evidence of disease (NED), and 226 healthy controls...
December 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30510852/-68-ga-psma-11-pet-ct-in-prostate-cancer-local-recurrence-impact-of-early-images-and-parametric-analysis
#13
Christos Sachpekidis, Leyun Pan, Boris A Hadaschik, Klaus Kopka, Uwe Haberkorn, Antonia Dimitrakopoulou-Strauss
68 Ga-PSMA-11 PET/CT performed 60 min post tracer injection (p.i.) can underestimate prostate cancer (PC) local recurrence, due to high 68 Ga-PSMA-11 urinary bladder accumulation. Aim of this analysis is to evaluate the complementary role of early dynamic and parametric PET imaging in patients with PC local recurrence. Sixteen patients with PC biochemical relapse attributed to local recurrence underwent dynamic 68 Ga-PSMA-11 PET/CT scanning of the pelvis and whole-body PET/CT. Data analysis was based on visual analysis of the PET/CT scans, SUV calculations, quantitative analysis based on two-tissue compartment and Patlak models as well as parametric imaging based on Patlak analysis...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30509284/impact-of-vmat-imrt-compared-to-3d-conformal-radiotherapy-on-anal-sphincter-dose-distribution-in-neoadjuvant-chemoradiation-of-rectal-cancer
#14
Hendrik Dapper, Iván Rodríguez, Stefan Münch, Jan C Peeken, Kai Borm, Stephanie E Combs, Daniel Habermehl
BACKGROUND: Neoadjuvant radio- or chemoradiation (nIRT) therapy is the standard treatment for loco-regional advanced rectal cancer patients of the lower or middle third. Currently, intensity modulated radiation therapy (IMRT) is not the recommended radiation technique even though IMRT has advantages compared to 3D-radiation regarding dose sparing to organs at risk like small bowel and urinary bladder. So far, the benefit of IMRT concerning the anal sphincter complex is not examined. With this study we intended to evaluate the dose distribution on the anal sphincters of rectal cancer patients treated with IMRT in comparison with 3D-techniques...
December 3, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/30509099/recurrent-oligometastatic-transitional-cell-bladder-carcinoma-is-there-room-for-radiotherapy
#15
M Augugliaro, G Marvaso, D Ciardo, D Zerini, G Riva, E Rondi, S Vigorito, S Comi, O De Cobelli, R Orecchia, B Alicja Jereczek-Fossa
The aim of our study was to retrospectively report on radiotherapy (RT) in the oligometastastic recurrence of bladder cancer. Thirteen patients treated for low-volume metastatic transitional cell urinary bladder carcinoma (TCC) were reviewed. The primary endpoint was to evaluate the safety and efficacy of RT, proposed as an alternative to systemic treatment and/or to defer the start of a systemic therapy. Inclusion criteria for our retrospective study were as follows: patients that received RT (without other local/systemic therapy) for oligometastatic TCC with lymph node, bone, lung lesions or local recurrence...
September 4, 2018: Neoplasma
https://www.readbyqxmd.com/read/30508511/effect-of-radiation-on-male-stress-urinary-incontinence-and-the-role-of-urodynamic-assessment
#16
Daniel Hoffman, Varun Vijay, Michelle Peng, Rachael D Sussman, Nirit Rosenblum, Benjamin M Brucker, Benoit Peyronnet, Victor W Nitti
OBJECTIVES: To evaluate the effect of radiation on male stress urinary incontinence and to assess the relative value of preoperative urodynamic testing in radiated vs non-radiated men with stress urinary incontinence (SUI). METHODS: A retrospective chart review of all male patients with SUI who underwent urodynamic testing (UDS) from 2010 until 2016 was performed. The impact of urodynamic findings on treatment decision making was assessed. Urodynamic parameters and treatment patterns of radiated vs...
November 30, 2018: Urology
https://www.readbyqxmd.com/read/30506536/-effect-of-bladder-training-on-bladder-function-recovery-in-the-male-patients-after-mid-low-rectal-cancer-surgery-a-prospective-open-randomized-controlled-study
#17
Yuhong Xie, Xiaojie Wang, Zhifen Chen, Pan Chi, Guoxian Guan, Huiming Lin, Xingrong Lu, Ying Huang, Zhengqiong Wang, Mingxing Wang, Jie Chen, Xiuying Li, Min Wang, Xuezhen Zheng, Ximei Zheng, Ran Li, Qianqian Lin
OBJECTIVE: To investigate the efficacy and safety of the bladder training in male patients before urinary catheter removal after mid-low rectal cancer surgery. METHODS: This was a prospective, open, randomized controlled study. INCLUSION CRITERIA: male patients; pathologically diagnosed as mid-low rectal adenocarcinoma; distance from tumor lower edge to anal margin ≤10 cm; standard radical surgery for rectal cancer, including intestinal resection and regional lymph node dissection...
November 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/30499629/robot-assisted-surgery-for-benign-distal-ureteral-strictures-step-by-step-technique-using-the-sp-%C3%A2-surgical-systemz
#18
Jihad Kaouk, Juan Garisto, Mohamed Eltemamy, Riccardo Bertolo
OBJECTIVES: To describe the step-by-step techniques for robotic ureteral reimplantation performed by using the Vinci SP® surgical system (Intuitive Surgical, Sunnyvale, CA). Different case-scenarios were included with an educational purpose. MATERIALS AND METHODS: Three consecutive patients diagnosed with distal benign ureteral strictures were counseled for ureteral reimplantation and accepted to undergo surgery performed by using the da Vinci SP® surgical system...
November 30, 2018: BJU International
https://www.readbyqxmd.com/read/30489454/orbital-metastasis-from-urothelial-carcinoma-a-comprehensive-literature-review
#19
Bonnie A Sklar, Kalla A Gervasio, Konstantin Karmazin, Albert Y Wu
PURPOSE: To review the clinical features of orbital and choroidal metastases from urothelial carcinomas of the urinary tract among cases reported in the literature, and to describe a case of orbital metastasis from bladder cancer presenting as apparent internuclear ophthalmoplegia. METHODS: Case reports of orbital and choroidal metastases from urothelial carcinomas published in the literature from 1965 to 2018 were reviewed. Data collected included patient demographics, cancer stage and primary site, time to onset of ocular symptoms, length of presenting ocular symptoms, types of primary ocular symptoms, diagnostic imaging, histology, systemic and ocular treatments, and survival time...
November 21, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/30483939/functional-annotation-and-analysis-of-dual-oxidase-1-duox1-a-potential-anti-pyocyanin-immune-component
#20
Muhammad Ibrahim Rashid, Amjad Ali, Saadia Andleeb
Dual Oxidase 1 (DUOX1) is a prominent immune system component primarily expressed in esophagus, lungs, skin, and urinary bladder including others. DUOX1 is involved in lactoperoxidase-mediated innate immunity at mucosal surfaces by generation of antimicrobial hypothiocyanite at the apical surface of epithelial lining. Upon detection of bacterial pathogens mainly Pseudomonas aeruginosa, DUOX1 is activated in bronchial epithelial cells. Both the host and pathogen enter a redox dual with DUOX1 and hypothiocyanite from host and Pyocyanin (PCN) as a redox active virulence factor from P...
November 27, 2018: Interdisciplinary Sciences, Computational Life Sciences
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