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Urinary bladder cancers

Malgorzata Maj, Anna Kokocha, Anna Bajek, Tomasz Drewa
Tissue engineering approaches offer alternative strategies for urinary diversion after radical cystectomy. Possible triggering of cancer recurrence remains, however, a significant concern in the application of stem-cell based therapies for oncological patients. Soluble mediators secreted by stem cells induce tissue remodelling effects, but may also promote cancer cells growth and metastasis. We observed a substantial increase in the concentration of IL-6 and IL-8 in the secretome of adipose-derived stem cells (ASCs) co-cultured with bladder cancer cells...
October 11, 2018: Scientific Reports
Zhongyuan Liu, Dalong Xie, Hui Zhang
Bladder cancer (BC) is one of the most common tumors in the urinary system. Noncoding RNAs are considered to take part in cellular phenotypes and are emerging as diagnostic and prognostic biomarkers of BC. The aim of this study is to investigate the clinical significance of neuroblastoma- associated transcript 1 (NBAT1) gene and its effects on malignant cellular phenotypes in BC. NBAT1 gene was low-expressed in BC tissues and cell lines and its low-expression was related with high pathological grade and metastasis of BC...
October 11, 2018: Cell Death & Disease
Yishuo Wu, Guangliang Jiang, Ning Zhang, Shenghua Liu, Xiaoling Lin, Chelsea Perschon, S Lilly Zheng, Qiang Ding, Xiang Wang, Rong Na, Jishan Sun, Jianfeng Xu
BACKGROUND: DNA methylation biomarkers for bladder cancer (BCa) have not been evaluated extensively in the Chinese population. OBJECTIVE: To develop and validate a urinary biomarker combination of methylation assays in a group of Chinese patients with hematuria. DESIGN, SETTING, AND PARTICIPANTS: A total of 192 urine samples were collected and evaluated from patients with microscopic or gross hematuria, including 97 BCa patients and 95 controls with benign diseases...
October 8, 2018: European Urology Focus
Ping Wu, Xiaofeng Meng, Huade Zheng, Qin Zeng, Tianfeng Chen, Wen Wang, Xia Zhang, Jianyu Su
Bladder cancer has become the most common malignant urinary carcinoma. Studies have shown that significant antioxidant and bladder cancer-fighting properties of several plant-based diets like Psidium guajava , ginger and amomum, are associated with their high kaempferol content. In this paper, we evaluated the antioxidant and anticancer activities of kaempferol and its mechanism of induction to apoptosis on bladder cancer cells. Our findings demonstrated that kaempferol showed an obvious radical scavenging activity in erythrocytes damaged by oxygen...
October 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Syuan-Hao Syu, Kai-Sheng Chan, Chi-Hao Hsiao, Wei-Yu Chen, Liang-Ming Lee, Yu-Ching Wen
Urinary bladder hemangiomas are rare, especially in children and adolescents. We present a case of a 17-year-old young man with persistent gross hematuria for 1 month. Computed tomography revealed a 3.6-cm mass on the superior anterior wall of the urinary bladder, which was highly suspected as a urachal tumor. We carried out an en bloc resection of the urachus and bladder tumor. The pathological report indicated a cavernous hemangioma of the urinary bladder. No tumor recurrence or bleeding was found during the 2-year follow-up...
October 8, 2018: Urology
Elroy Patrick Weledji, Divine Eyongeta, Eleanour Ngounou
INTRODUCTION: Normal voiding needs a coordinated, sustained bladder contraction of adequate size and duration. It requires a decrease in resistance of the bladder neck and urethra and no obstruction. Voiding problems can arise from abnormal storage of urine or problems with urinary control. The aim of this article was to review the functional anatomy and physiology of urinary control and micturition and the pathophysiology of urinary control problems. MATERIALS AND METHODS: The Medline (PubMed) database, Cochrane Library, and Science Citation Index were searched electronically to identify original published studies on bladder anatomy, function and urinary control...
October 10, 2018: Clinical Anatomy
G Schooneveldt, H P Kok, A Bakker, E D Geijsen, M C C M Hulshof, T M de Reijke, J Crezee
PURPOSE: Loco-regional hyperthermia combined with mitomycin C is used for treatment of nonmuscle invasive bladder cancer (NMIBC). Air pockets may be present in the bladder during treatment. The aim of this study is to quantify the effect of air pockets on the thermal dose of the bladder. METHODS: We analysed 16 patients treated for NMIBC. Loco-regional hyperthermia was performed with the in-house developed 70 MHz AMC-4 hyperthermia device. We simulated treatments with the clinically applied device settings using Plan2Heat (developed in-house) including the air pockets delineated on CT scans made following treatment, and with the same volume filled with urine...
October 10, 2018: International Journal of Hyperthermia
Arlette Yumba Mpanga, Danuta Siluk, Julia Jacyna, Oliwia Szerkus, Renata Wawrzyniak, Marcin Markuszewski, Marcin Matuszewski, Roman Kaliszan, Michał Jan Markuszewski
Bladder cancer constitutes the ninth most common cancer worldwide and, despite continuous development of new diagnostic approaches, the thirteenth leading cause of global cancer mortality. In our previous untargeted urine metabolomic investigation, seventeen metabolites were found to be statistically differentiating bladder cancer patients and healthy volunteers. Therefore, the main goal of this study was to develop and validate an analytical method for simultaneous quantitative determination of those metabolites using reversed phase high-performance liquid chromatography coupled with triple quadrupole mass spectrometry technique (RP-HPLC-QQQ/MS)...
December 11, 2018: Analytica Chimica Acta
Tomoyasu Tsushima, Takafumi Miura, Takahiko Hachiya, Ichiro Nakamura, Toyoko Yamato, Takeshi Kishida, Yoshinori Tanaka, Shin Irie, Norio Meguro, Takashi Kawahara, Nobuhisa Nakajima
BACKGROUND: Urological symptoms such as gross hematuria, lower and upper urinary tract symptoms, and bladder pain are common in and distressing for patients with advanced cancer. Although palliation of urological symptoms is important to improve the quality of life of cancer patients and their families and caregivers, clinical guidelines for managing urological symptoms in patients with cancer have not been published. METHODS: Following the formal guideline development process, the Japanese Society for Palliative Medicine (JSPM) developed comprehensive clinical guidelines for the management of urological symptoms in patients with cancer...
October 5, 2018: Journal of Palliative Medicine
Munseok Seo, James R Langabeer Ii
OBJECTIVES: To examine survivorship disparities in demographic factors and risk status for non-muscle-invasive bladder cancer (NMIBC), which accounts for more than 75% of all urinary bladder cancers, but is highly curable with early identification and treatment. METHODS: We used the US National Cancer Institute's Surveillance, Epidemiology, and End Results registries over a 19-year period (1988-2006) to examine survivorship disparities in age, sex, race/ethnicity, and marital status of patients and risk status classified by histologic grade, stage, size of tumor, and number of multiple primary tumors among NMIBC patients (n=29 326)...
September 2018: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
Minsun Jung, Bohyun Kim, Kyung Chul Moon
AIMS: Immunohistochemical (IHC) staining for CK5/6, CD44, and CK20 has been significantly associated with the prognosis of urinary bladder urothelial carcinoma and probably reflects its molecular characteristics. Because of its rarity, the IHC-based subgroups and their prognostic effects on upper tract urothelial carcinoma (UTUC) are still unclear, especially in non-muscle-invasive papillary UTUC. METHODS AND RESULTS: IHC staining for CK5/6, CK20, and CD44 was analyzed in 211 patients with non-muscle-invasive papillary UTUC...
October 4, 2018: Histopathology
Moritz Maas, Jens Bedke, Arnulf Stenzl, Tilman Todenhöfer
PURPOSE: Diagnosis and follow-up in patients with non-muscle invasive bladder cancer (NMIBC) rely on cystoscopy and urine cytology. The aim of this review paper is to give an update on urinary biomarkers and their diagnosis and surveillance potential. Besides FDA-approved markers, recent approaches like DNA methylation assays, mRNA gene expression assays and cell-free DNA (cfDNA) are evaluated to assess whether replacing cystoscopy with urine markers is a potential scenario for the future...
October 3, 2018: World Journal of Urology
Dal Mo Yang, Hyun Cheol Kim, Sang Won Kim, Sung Jig Lim, Ji Su Kim
Based on sonographic findings, colovesical fistula was diagnosed in a 71-year-old man with sigmoid colon cancer. Gray-scale sonography revealed an irregular thickening of the sigmoid colon wall abutting the urinary bladder which also showed thickening in the region of contact. Color Doppler sonography showed a twinkling artifact within the thickened bladder wall. Contrast-enhanced computed tomography scan showed luminal communication between the sigmoid colon and the bladder in the region of thickening.
July 2018: Journal of Medical Ultrasound
Andreja Erman, Gregor Kapun, Sara Novak, Mojca Pavlin, Goran Dražić, Damjana Drobne, Peter Veranič
The majority of bladder cancers in humans are non-muscle-invasive cancers that recur frequently after standard treatment procedures. Mouse models are widely used to develop anti-tumor treatments. The purpose of our work was to establish an orthotopic mouse bladder tumor model and to explore early stages of implantation of cancerous MB49 cells in vivo using various labeling and microscopic techniques. To distinguish cancer cells from normal urothelial cells in mouse urinary bladders, we performed molecular characterization of MB49 cells before intravesical injection experiments...
October 3, 2018: Histochemistry and Cell Biology
Zhi-Yong Wang, Hong-Yang Li, Hao Wang, Qiang Chi, Ying Liu, Xiu-Ming Li
Aims: Bladder cancer-specific nuclear matrix protein-4 (BLCA-4) is a protein expressed mainly in bladder cancer tissues. Therefore, the aim of this study was to investigate its assisting diagnostic potential in non-muscle-invasive bladder cancer (NMIBC). Methods: Twenty patients with NMIBC, 20 with benign prostatic hyperplasia (BPH), and 20 normal controls were included in this study. Blood and urine samples were collected from all patients. Moreover, cancer foci and adjacent tissue samples were collected from NMIBC patients, and normal bladder tissue samples were collected from patients with BPH...
2018: Disease Markers
Samuel M Cohen
Crystalluria can involve the kidney and lower urinary tract, can produce acute and chronic effects, and occurs in all mammalian species. Most commonly urinary crystals contain calcium. Numerous other endogenous and exogenous substances can produce crystalluria. Crystals are identified in kidneys of many species, up to 100% in certain rat strains. More severe renal disease (acute tubular necrosis and chronic renal disease) can be secondary to crystal accumulation, such as observed with melamine-cyanuric acid in cats and dogs...
October 1, 2018: Toxicologic Pathology
Farhad Pishgar, Erfan Amini, Kimiya Gohari, Arya Aminorroaya, Ali Sheidaei, Yasna Rostamabadi, Hooman Ebrahimi, Moein Yoosefi, Shohreh Naderimagham, Nazila Rezaei, Mitra Modirian, Alireza Namazi Shabestari, Farzad Kompani, Farshad Farzadfar
PURPOSE: To study trends of urological cancers mortalities in Iran between 1990 and 2015 as a part of a larger project named national and subnational burden of diseases, injuries, and risk factors. METHODS: The primary dataset of this project comprises data of national death registration system. Cause-specific mortality fraction for each age, sex, province, and year group was calculated using a two-stage mixed effects and spatiotemporal models, and then these fractions were applied to all-cause mortality rates, obtained from a parallel study to estimate mortality rates attributable to each cause...
October 1, 2018: Asia-Pacific Journal of Clinical Oncology
Norie Sawada
Arsenic is widely distributed in nature, and humans are exposed to arsenic through air, water, beverages, and food. On the bases of previous studies of highly exposed populations, arsenic is designated as a Group 1 human carcinogen by the International Agency for Research on Cancer (IARC), and IARC has established a causal role for arsenic in cancers of the urinary bladder, lung, and skin in humans. However, there are very few epidemiological studies of the association between low-moderate arsenic exposure and cancer...
2018: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
M Spinelli, R Gillibrand
High grade bladder malignancies have tendency to local and distant invasion. The most commonly involved sites are lymph nodes, lungs, bone and liver. Muscle metastases are generally rare and have been described in few cases of Genito-Urinary cancer. In this work we describe a rare case of high grade transitional cell carcinoma from bladder metastatising to the left gluteal muscle together with the review of the pertinent literature.
March 2018: Pathologica
Lindsey Tamiko Saldin, Shil Patel, Li Zhang, Luai Huleihel, George S Hussey, David Gabriele Nascari, Lina Maria Quijano, Xue Li, Divya Raghu, Anant Kaur Bajwa, Nicholas G Smith, Christopher Chi-Heng Chung, Ashten N Omstead, Juliann E Kosovec, Blair A Jobe, Neill J Turner, Ali H Zaidi, Stephen F Badylak
Extracellular matrix (ECM) bioscaffolds have been successfully used to treat 5 esophageal adenocarcinoma (EAC) patients following resection of neoplastic mucosal tissue. The present study evaluated the in vitro effect of ECM harvested from non-malignant, decellularized tissue on EAC cell phenotype to understand the molecular mechanisms underlying the clinical findings. Non-malignant (Het-1A), metaplastic (CP-A), and neoplastic (SK-GT-4, OE33) esophageal epithelial cells were exposed to ECM degradation products (250 ug/mL) prepared from heterologous urinary bladder tissue or homologous esophageal mucosa tissue, and evaluated for cell morphology, cell function, and EAC signaling pathways...
September 27, 2018: Tissue Engineering. Part A
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