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Lithium Depression

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https://www.readbyqxmd.com/read/30102627/a-pilot-study-of-the-effectiveness-of-lithium-versus-quetiapine-immediate-release-monotherapy-in-patients-with-bipolar-spectrum-disorders
#1
Keming Gao, Toyomi Goto, Chengmei Yuan, Brittany Brownrigg, Carla Conroy, Philip K Chan, Mary Beth Serrano, Stephen J Ganocy, Fang Fang, Joseph R Calabrese
OBJECTIVE: The aim of this study was to compare the effectiveness of lithium versus quetiapine immediate release (IR) monotherapy in patients with bipolar I, II, or subthreshold bipolar disorder at any phase. METHODS: Eligible patients were randomized to lithium or quetiapine IR for 16 weeks. The difference in the time to discontinuation from study due to "all causes" between lithium and quetiapine IR groups and changes from baseline to 8 and 16 weeks in depression, mania, anxiety, quality of life (QOL), metabolic profiles, and proinflammatory markers were compared...
August 10, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30092919/pharmacologic-treatment-of-perinatal-depression
#2
REVIEW
Mary C Kimmel, Elizabeth Cox, Crystal Schiller, Edith Gettes, Samantha Meltzer-Brody
This review provides information about medications used to treat perinatal depression, including guidance around when to use certain medications and when to consult a mental health provider. For each group of medications, including selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, mirtazapine, bupropion, lithium, atypical antipsychotics, and lamotrigine, the risks and benefits of treatment during pregnancy and lactation are reviewed, and unique qualities of each medication...
September 2018: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/30029078/labial-repositioning-using-polymethylmethracylate-pmma-based-cement-for-esthetic-smile-rehabilitation-a-case-report
#3
Toni Arcuri, Maykson Feitosa Pereira da Costa, Iury Machado Ribeiro, Byron Daia Barreto, João Paulo Lyra eSilva
INTRODUCTION: One of the most common esthetic complaints among dental patients is a gingival smile, which may be of multifactorial etiology, e.g. gingival hyperplasia, skeletal deformities featuring overgrowth of the anterior maxilla, altered passive eruption, maxillary alveolar tooth extrusion, fine lip and hypermobility of lip elevator muscles, which must be diagnosed prior to treatment so that the appropriate management approach can be selected. Maxillary overgrowth may give rise to subnasal skeletal depression where the upper lip retracts to during smiling, causing gingival exposure...
July 17, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30012135/atorvastatin-in-the-treatment-of-lithium-induced-nephrogenic-diabetes-insipidus-the-protocol-of-a-randomized-controlled-trial
#4
Jocelyn Fotso Soh, Susana G Torres-Platas, Serge Beaulieu, Outi Mantere, Robert Platt, Istvan Mucsi, Sybille Saury, Suzane Renaud, Andrea Levinson, Ana C Andreazza, Benoit H Mulsant, Daniel Müller, Ayal Schaffer, Annemiek Dols, Pablo Cervantes, Nancy Cp Low, Nathan Herrmann, Birgitte M Christensen, Francesco Trepiccione, Tarek Rajji, Soham Rej
BACKGROUND: Lithium is the gold-standard treatment for bipolar disorder, is highly effective in treating major depressive disorder, and has anti-suicidal properties. However, clinicians are increasingly avoiding lithium largely due to fears of renal toxicity. Nephrogenic Diabetes Insipidus (NDI) occurs in 15-20% of lithium users and predicts a 2-3 times increased risk of chronic kidney disease (CKD). We recently found that use of statins is associated with lower NDI risk in a cross-sectional study...
July 16, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29929874/maternal-and-infant-outcomes-associated-with-lithium-use-in-pregnancy-an-international-collaborative-meta-analysis-of-six-cohort-studies
#5
Trine Munk-Olsen, Xiaoqin Liu, Alexander Viktorin, Hilary K Brown, Arianna Di Florio, Brian M D'Onofrio, Tara Gomes, Louise M Howard, Hind Khalifeh, Holly Krohn, Henrik Larsson, Paul Lichtenstein, Clare L Taylor, Inge Van Kamp, Richard Wesseloo, Samantha Meltzer-Brody, Simone N Vigod, Veerle Bergink
BACKGROUND: Concerns about teratogenicity and maternal and offspring complications restrict the use of lithium during pregnancy for the treatment of mood disorders. We aimed to investigate the association between in-utero lithium exposure and risk of pregnancy complications, delivery outcomes, neonatal morbidity, and congenital malformations. METHODS: In this meta-analysis, primary data from pregnant women and their children from six international cohorts based in the community (Denmark, Sweden, and Ontario, Canada) and in clinics (the Netherlands, UK, and USA) were analysed...
August 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29904359/analysis-of-the-influence-of-micrornas-in-lithium-response-in-bipolar-disorder
#6
Céline S Reinbold, Andreas J Forstner, Julian Hecker, Janice M Fullerton, Per Hoffmann, Liping Hou, Urs Heilbronner, Franziska Degenhardt, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Raffaella Ardau, Bárbara Arias, Lena Backlund, Antonio Benabarre, Susanne Bengesser, Abesh K Bhattacharjee, Joanna M Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Guo-Bo Chen, Hsi-Chung Chen, Caterina Chillotti, Scott R Clark, Francesc Colom, David A Cousins, Cristiana Cruceanu, Piotr M Czerski, Alexandre Dayer, Bruno Étain, Peter Falkai, Louise Frisén, Sébastien Gard, Julie S Garnham, Fernando S Goes, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Stéphane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Nina Lackner, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Carlos A López Jaramillo, Glenda MacQueen, Mirko Manchia, Lina Martinsson, Manuel Mattheisen, Michael J McCarthy, Susan L McElroy, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Urban Ösby, Norio Ozaki, Roy H Perlis, Andrea Pfennig, Daniela Reich-Erkelenz, Guy A Rouleau, Peter R Schofield, K Oliver Schubert, Barbara W Schweizer, Florian Seemüller, Giovanni Severino, Tatyana Shekhtman, Paul D Shilling, Kazutaka Shimoda, Christian Simhandl, Claire M Slaney, Jordan W Smoller, Alessio Squassina, Thomas J Stamm, Pavla Stopkova, Sarah K Tighe, Alfonso Tortorella, Gustavo Turecki, Julia Volkert, Stephanie H Witt, Adam J Wright, L Trevor Young, Peter P Zandi, James B Potash, J Raymond DePaulo, Michael Bauer, Eva Reininghaus, Tomáš Novák, Jean-Michel Aubry, Mario Maj, Bernhard T Baune, Philip B Mitchell, Eduard Vieta, Mark A Frye, Janusz K Rybakowski, Po-Hsiu Kuo, Tadafumi Kato, Maria Grigoroiu-Serbanescu, Andreas Reif, Maria Del Zompo, Frank Bellivier, Martin Schalling, Naomi R Wray, John R Kelsoe, Martin Alda, Francis J McMahon, Thomas G Schulze, Marcella Rietschel, Markus M Nöthen, Sven Cichon
Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. This is supported by the largest genome-wide association study (GWAS) of lithium response to date conducted by the International Consortium on Lithium Genetics (ConLiGen). Recently, we performed the first genome-wide analysis of the involvement of miRNAs in BD and identified nine BD-associated miRNAs...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29902821/lithium-clinics-in-berlin-and-dresden-a-50-year-experience
#7
Werner Felber, Michael Bauer, Ute Lewitzka, Bruno Müller-Oerlinghausen
Although lithium's serendipitous discovery as a medication for depression dates back more than 200 years, the first scientific evidence that it prevents mania and depression arose only in the 1960s. However, at that time there was a lack of knowledge about how to administer and monitor lithium therapy safely and properly. The lithium clinics in Dresden and Berlin were remarkably similar in their beginnings in the late 1960s regarding patient numbers and scientific expertise without being aware of one another due to the Iron Curtain separating Germany into a western and eastern part until 1990...
June 14, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29895414/lithium-levels-in-tap-water-and-psychotic-experiences-in-a-general-population-of-adolescents
#8
Shinji Shimodera, Shinsuke Koike, Shuntaro Ando, Syudo Yamasaki, Ryosuke Fujito, Kaori Endo, Yudai Iijima, Yu Yamamoto, Masaya Morita, Ken Sawada, Nobuki Ohara, Yuji Okazaki, Atsushi Nishida
Recently, several epidemiologic studies have reported that lithium in drinking water may be associated with lower rates of suicide mortality, lower incidence of dementia, and lower levels of adolescents' depression and aggression at the population level. However, to our knowledge, no study has investigated lithium level in tap water in relation to psychotic experiences in a general population of adolescents. This is the first study to investigate this using a large dataset. Information on psychotic experiences, distress associated with these experiences, and depressive symptoms were collected in 24 public junior high schools in Kochi Prefecture in Japan...
June 9, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29873477/a-universal-strategy-to-prepare-sulfur-containing-polymer-composites-with-desired-morphologies-for-lithium-sulfur-batteries
#9
Shao-Zhong Zeng, Xierong Zeng, Wenxuan Tu, Haitao Huang, Liang Yu, Yuechao Yao, Nengzhi Jin, Qi Zhang, Jizhao Zou
Lithium-sulfur (Li-S) batteries are probably the most promising candidates for the next-generation batteries owing to their high energy density. However, Li-S batteries face severe technical problems where the dissolution of intermediate polysulfides is the biggest problem because it leads to the degradation of the cathode and the lithium anode, and finally the fast capacity decay. Compared with the composites of elemental sulfur and other matrices, sulfur-containing polymers (SCPs) have strong chemical bonds to sulfur and therefore show low dissolution of polysulfides...
July 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29869405/adjunctive-thyroid-hormone-treatment-in-rapid-cycling-bipolar-disorder-a-double-blind-placebo-controlled-trial-of-levothyroxine-l-t-4-and-triiodothyronine-t-3
#10
Patricia D Walshaw, Laszlo Gyulai, Michael Bauer, Mark S Bauer, Brian Calimlim, Catherine A Sugar, Peter C Whybrow
OBJECTIVES: This report describes the first comparative double-blind, placebo-controlled trial of levothyroxine (L-T4 ) and triiodothyronine (T3 ) as adjunctive treatments in rapid cycling bipolar disorder. METHODS: Thirty-two treatment-resistant, rapid cycling patients who had failed a trial of lithium were randomized into three treatment arms: L-T4 , T3 , or placebo. They were followed for ≥4 months with weekly clinical and endocrine assessments. RESULTS: There were no statistically significant differences between the groups in age, gender, duration of illness, or thyroid status...
June 4, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29843019/endoplasmic-reticulum-stress-in-bipolar-disorder-bip-and-chop-gene-expression-and-xbp1-splicing-analysis-in-peripheral-blood
#11
Susanne A Bengesser, Eva Z Reininghaus, Nina Dalkner, Armin Birner, Helena Hohenberger, Robert Queissner, Frederike Fellendorf, Martina Platzer, Rene Pilz, Carlo Hamm, Alexandra Rieger, Hans-Peter Kapfhammer, Harald Mangge, Bernd Reininghaus, Nathalie Meier-Allard, Anika Stracke, Robert Fuchs, Sandra Holasek
BACKGROUND: Endoplasmic Reticulum stress activates the Unfolded Protein Response, which is partially impaired in Bipolar Disorder (BD) according to previous in-vitro studies. Thus, BiP and CHOP gene expression and XBP1 splicing were analyzed in peripheral blood of study participants with BD and controls. METHODS: RNA was isolated from fasting blood of study participants with BD (n = 81) and controls (n = 54) and reverse transcribed into cDNA. BiP and CHOP gene expression was analyzed with quantitative RT-PCR...
May 21, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29789269/anterior-cingulate-cortex-glutamatergic-metabolites-and-mood-stabilizers-in-euthymic-bipolar-i-disorder-patients-a-proton-magnetic-resonance-spectroscopy-study
#12
Marcio Gerhardt Soeiro-de-Souza, Maria Concepcion Garcia Otaduy, Rodrigo Machado-Vieira, Ricardo Alberto Moreno, Fabiano G Nery, Claudia Leite, Beny Lafer
BACKGROUND: Bipolar disorder is a chronic and recurrent illness characterized by depressive and manic episodes. Proton magnetic resonance spectroscopy (1 H-MRS) studies have demonstrated glutamate (Glu) system abnormalities in BD, but it is unclear how Glu varies among mood states and how medications modulate it. The objective of this study was to investigate the influence of mood stabilizers on anterior cingulate cortex Glu levels using 1 H-MRS during euthymia. METHODS: One hundred twenty-eight bipolar I disorder (BDI) euthymic subjects and 80 healthy control subjects underwent 3T brain 1 H-MRS imaging examination including acquisition of an anterior cingulate cortex single voxel (8 cm3 ) 1 H-MRS, based on a point resolved spectroscopy (PRESS) sequence with an echo time of 80 ms and a repetition time of 1500 ms (BIPUSP MRS study)...
March 31, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29772867/-depressant-effect-of-lithium-on-apoptosis-of-nerve-cells-of-adult-rats-after-spinal-cord-injury
#13
Fang Wang, Chao Zhou, Zheng-Chao Gao, Yu-Huan Li, Wen-Long Yang, Dong Wang, Hao-Peng Li, Xi-Jing He
OBJECTIVE: To study whether lithium agent produces neuroprotective effect by inhibiting the nerve cell apoptosis of rats after spinal cord injury. METHODS: Forty-two male SD rats weighing 200 to 250 g were randomly divided into 3 groups: blank control group( n =6) without surgery, normal saline(NS) group( n =18) with intraperitoneal injection of NS (40 mg/kg); and Lithium chloride (Licl) group ( n =18) with intraperitoneal injection of Licl (40 mg/kg). After Allen method modeling, Licl group started intraperitoneal injection of Licl solution (40 mg·kg⁻¹·d⁻¹) within 15 min after operation to the second week...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29756288/mixed-states-in-bipolar-and-major-depressive-disorders-systematic-review-and-quality-appraisal-of-guidelines
#14
REVIEW
N Verdolini, D Hidalgo-Mazzei, A Murru, I Pacchiarotti, L Samalin, A H Young, E Vieta, A F Carvalho
OBJECTIVE: This systematic review provided a critical synthesis and a comprehensive overview of guidelines on the treatment of mixed states. METHOD: The MEDLINE/PubMed and EMBASE databases were systematically searched from inception to March 21st, 2018. International guidelines covering the treatment of mixed episodes, manic/hypomanic, or depressive episodes with mixed features were considered for inclusion. A methodological quality assessment was conducted with the Appraisal of Guidelines for Research and Evaluation-AGREE II...
May 13, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29720950/sensorimotor-gating-in-depressed-and-euthymic-patients-with-bipolar-disorder-analysis-on-prepulse-inhibition-of-acoustic-startle-response-stratified-by-gender-and-state
#15
Junko Matsuo, Miho Ota, Shinsuke Hidese, Toshiya Teraishi, Hiroaki Hori, Ikki Ishida, Moeko Hiraishi, Hiroshi Kunugi
Background: Prepulse inhibition (PPI) of the acoustic startle reflex is an operational measure of sensorimotor gating. The findings on PPI deficits in bipolar disorder (BD) are inconsistent among studies due to various confounding factors such as gender. This study aimed to assess sensorimotor gating deficits in patients with BD stratified by gender and state (depressed/euthymic), and to explore related clinical variables. Methods: Subjects were 106 non-manic BD patients (26 BD I and 80 BD II; 63 with depression and 43 euthymic) and 232 age-, gender-, and ethnicity-matched (Japanese) healthy controls...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29697250/effects-of-nanofiber-architecture-and-antimony-doping-on-the-performance-of-lithium-rich-layered-oxides-enhancing-lithium-diffusivity-and-lattice-oxygen-stability
#16
Ruizhi Yu, Zhijuan Zhang, Sidra Jamil, Jiancheng Chen, Xiaohui Zhang, Xianyou Wang, Zhenhua Yang, Hongbo Shu, Xiukang Yang
Li-rich layered oxides (LLOs) with high specific capacities are favorable cathode materials with high-energy density. Unfortunately, the drawbacks of LLOs such as oxygen release, low conductivity, and depressed kinetics for lithium ion transport during cycling can affect the safety and rate capability. Moreover, they suffer severe capacity and voltage fading, which are major challenges for the commercializing development. To cure these issues, herein, the synthesis of high-performance antimony-doped LLO nanofibers by an electrospinning process is put forward...
May 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29679069/pharmacological-treatment-of-adult-bipolar-disorder
#17
REVIEW
Ross J Baldessarini, Leonardo Tondo, Gustavo H Vázquez
We summarize evidence supporting contemporary pharmacological treatment of phases of BD, including: mania, depression, and long-term recurrences, emphasizing findings from randomized, controlled trials (RCTs). Effective treatment of acute or dysphoric mania is provided by modern antipsychotics, some anticonvulsants (divalproex and carbamazepine), and lithium salts. Treatment of BD-depression remains unsatisfactory but includes some modern antipsychotics (particularly lurasidone, olanzapine + fluoxetine, and quetiapine) and the anticonvulsant lamotrigine; value and safety of antidepressants remain controversial...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29678455/different-behavioral-and-pathological-changes-between-epilepsy-associated-depression-and-primary-depression-models
#18
Wei-Feng Peng, Fan Fan, Xin Li, Qian-Qian Zhang, Jing Ding, Xin Wang
PURPOSE: Comorbid depression is common in patients with epilepsy. However, the epilepsy-associated depression is generally atypical and has not been fully recognized by neurologists. This study aimed to compare the behavioral and pathological changes between the chronic lithium chloride-pilocarpine rat epilepsy model (Licl-pilocarpine model) and the Chronic Unpredictable Mild Stress rat depression model (CUMS model), to evaluate for differences between epilepsy-associated depression and primary depression...
June 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29677623/cerebrospinal-fluid-fgf23-levels-correlate-with-a-measure-of-impulsivity
#19
Hui Li, Zhiyong Cao, Jinzhong Xu, Fan Wang, Rongrong Xiong, Zeping Xu, Xianming Luo, Guohua Li, Xingqi Tan, Zhiyang Liu, Zhiqin Gao, Yimin Kang, Jian Xiao, Yanlong Liu, Xiaokun Li
Fibroblast growth factor 23 (FGF23) is a bone-derived protein produced mainly by osteocytes and osteoblasts and at low levels in specific parts of the brain. It has been shown to associate with mood regulation. Lithium treatment gives rise to significant elevations of serum FGF23 levels in depressive patients. High peripheral blood FGF23 levels correlated with poor cognitive performance in hemodialysis patients. However, no direct evidence demonstrates a relationship between FGF23 and mood regulation. In this study, we aimed to measure the concentration of cerebrospinal fluid (CSF) FGF23 and to explore its relationship with a cluster of emotional characteristics...
June 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29672801/antisuicidal-effects-in-mood-disorders-are-they-unique-to-lithium
#20
Leonardo Tondo, Ross J Baldessarini
INTRODUCTION: Suicidal behavior is strongly associated with depression in major depressive (MDD) and bipolar (BD) disorders, especially with associated behavioral activation, dysphoria, or agitation. A rare intervention with evidence of suicide risk-reducing as well as mood-stabilizing effects in mood disorder patients is lithium. METHODS: We reviewed available research evidence on associations of long-term treatment with lithium with risk of suicidal behavior. We meta-analyzed 12 randomized trials in 10 reports (with at least 1 suicide in either treatment arm) including both BD and MDD subjects, with particular attention to comparisons of lithium with placebo or other pharmacological treatments...
April 19, 2018: Pharmacopsychiatry
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