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Lithium Depression

Roghayeh Naserkhaki, Selva Zamanzadeh, Hossein Baharvand, Seyed Massood Nabavi, Hossein Pakdaman, Sahba Shahbazi, Masood Vosough, Gholam Ghaedi, Abdolrazagh Barzegar, Davood Mirtorabi, Javad Hedayatshodeh, Ehsan Ehsani, Mojtaba Falahati, Mohammad Javad Hajipour, Koorosh Shahpasand
Bipolar disorder is a complex neuropsychiatric disorder, characterized by intermittent episodes of mania and depression. Recent studies have indicated argyrophilic grains, composed of hyperphosphorylated tau, are observable in postmortem brains of bipolar patients. Anyhow, it remains uncertain how tau hyperphosphorylation results in neurodegeneration upon the disease. Recent studies have demonstrated that phosphorylated tau at Thr231 exists in two distinct cis and trans conformations, in which cis pT231-tau is highly neurotoxic and acts as an early driver of tauopathy in several neurodegenerative diseases...
January 15, 2019: ACS Chemical Neuroscience
Niamh M Ganter, Kezanne Tong, Colm McDonald, Anne M Doherty
INTRODUCTION: Lithium is a medication indicated for the treatment of bipolar disorder and treatment-resistant depression, with a narrow therapeutic index. Overdose, either acute or chronic can result in neurological symptoms, requiring dialysis and admission to intensive care in some cases. Lithium toxicity is avoidable with careful monitoring. However, we have noted several recent cases of lithium toxicity in our local service and thus sought to investigate this issue in a more systematic manner...
January 10, 2019: Irish Journal of Medical Science
L Perez-Caballero, S Torres-Sanchez, C Romero-López-Alberca, F González-Saiz, J A Mico, Esther Berrocoso
Major depressive disorder is a severe, disabling disorder that affects around 4.7% of the population worldwide. Based on the monoaminergic hypothesis of depression, monoamine reuptake inhibitors have been developed as antidepressants and nowadays, they are used widely in clinical practice. However, these drugs have a limited efficacy and a slow onset of therapeutic action. Several strategies have been implemented to overcome these limitations, including switching to other drugs or introducing combined or augmentation therapies...
January 10, 2019: Cell and Tissue Research
Shyr-Shea Chang, Tom Chou
Bipolar disorder is a common psychiatric dysfunction characterized by recurring episodes of mania and depression. Despite its prevalence, the causes and mechanisms of bipolar disorder remain largely unknown. Recently, theories focusing on the interaction between emotion and behavior, including those based on dysregulation of the so-called behavioral approach system (BAS), have gained popularity. Mathematical models built on this principle predict bistability in mood and do not invoke intrinsic biological rhythms that may arise from interactions between mood and expectation...
December 2018: Computational psychiatry
Sina Stühler, Arnim Quante
OBJECTIVE: Augmentation with lithium is one of the treatment options in therapy-resistant depression. This review presents the current data concerning the use of lithium in elderly patients with unipolar depression. METHOD: Through a selective literature search in the database PubMed, 15 relevant articles were identified and included. RESULTS: Both the clinical trials and reviews report in favor of lithium augmentation in elderly patients...
December 2018: Fortschritte der Neurologie-Psychiatrie
Christoforos Iraklis Giakoumatos, David Osser
BACKGROUND: The Psychopharmacology Algorithm Project at the Harvard South Shore Program presents evidence-based recommendations considering efficacy, tolerability, safety, and cost. Two previous algorithms for unipolar nonpsychotic depression were published in 1993 and 1998. New studies over the last 20 years suggest that another update is needed. METHODS: The references reviewed for the previous algorithms were reevaluated, and a new literature search was conducted to identify studies that would either support or alter the previous recommendations...
January 2019: Harvard Review of Psychiatry
Jocelyn Fotso Soh, Sivan Klil-Drori, Soham Rej
Lithium is the gold-standard treatment for bipolar disorder, and is effective in the management of manic, depressive, and maintenance phases of bipolar disorder treatment. Despite this, the implications of lithium use in the older population remain less understood. This critical narrative review aims to better understand the impact of lithium in older age bipolar disorder (OABD), including tolerability and efficacy, based on up-to-date evidence. Relevant studies of efficacy, effectiveness, and tolerability published any time prior to May 2018 were identified using the PubMed keyword search "lithium older adult bipolar disorder" and references from recent international bipolar disorder guidelines...
January 7, 2019: Drugs & Aging
Min Jiang, Bingqing Gan, Yongqi Deng, Yin Xiong, Ruixuan Tan
Lithium⁻sulfur (Li-S) batteries, due to their high theoretical capacity, intrinsic overcharge protection, and low cost, are considered as the most promising candidates for next-generation energy storage systems. To promote widespread use of Li-S batteries, various tactics have been reported to improve the columbic efficiency and to suppress the shuttle effect. Herein, we report a novel polymeric sulfur via heat radical polymerization, for the Li-S battery. The insolubles after CS₂ washing, and the changes in XRD (X-ray diffraction) results imply the formation of polymeric sulfur...
December 25, 2018: Materials
Sarah Laberge, Alexander M Crizzle
Psychotropic medications and alcohol are potential risk factors for falls in older adults. However, there has been no appraisal of the literature on whether these medications, both singly and in combination with alcohol, are associated with falls in community dwelling older adults (those aged 60 years and older living independently without care). Four databases (PubMed, EMBASE, CINAHL and SCOPUS) and the grey literature (i.e. WHO, Public Health Agency of Canada) were searched using the following terms: benzodiazepine, anti-psychotics, anti-depressants, anti-epileptic, lithium, memantine, anti-hypertensives: drug or medication, aged or elderly or older adult or senior, accidental falls or falls or falling, and alcohol...
December 17, 2018: Clinical Drug Investigation
Sandra K Bopp, Urs Heilbronner, Peter Schlattmann, Thomas W Mühleisen, Tom Bschor, Christoph Richter, Bruno Steinacher, Thomas J Stamm, Angela Merkl, Stefan Herms, Stephan Köhler, Philipp Sterzer, Rainer Hellweg, Andreas Heinz, Sven Cichon, Undine E Lang, Thomas G Schulze, Mazda Adli, Roland Ricken
Weight gain is a common adverse effect of lithium augmentation. Previous studies indicate an impact of genetic variants at the leptin gene on weight gain as a consequence of psychopharmacological treatment. The primary aim of our study was to identify variants at the leptin locus that might predict lithium-induced weight gain. The secondary aim was to investigate if these variants modulate leptin levels. In 180 patients with acute major depressive disorder, body mass index was measured before and after 4 weeks of lithium augmentation, in a subsample also after 4 and/or 7 months...
December 13, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Artur Reginia, Jolanta Kucharska-Mazur, Marcin Jabłoński, Marta Budkowska, Barbara Dołȩgowska, Leszek Sagan, Błazej Misiak, Mariusz Z Ratajczak, Janusz K Rybakowski, Jerzy Samochowiec
Introduction: The immune system is undoubtedly involved in the pathogenesis of various psychiatric disorders, such as schizophrenia, bipolar disorder, or depression. Although its role is not fully understood, it appears that this area of research can help to understand the etiology of mental illness. One of the components of the human immune system is the complement system, which forms a part of the innate immune response. Physiologically, except for its essential protective role, it is a vital element in the regeneration processes, including neurogenesis...
2018: Frontiers in Psychiatry
Luiza Spohr, Mayara Sandrielly Pereira Soares, Pathise Souto Oliveira, Bruna da Silveira de Mattos, Natália Pontes Bona, Nathalia Stark Pedra, Fernanda Cardoso Teixeira, Carlus Augustu Tavares do Couto, Vitor Clasen Chaves, Flávio Henrique Reginatto, Meibel Teixeira Lisboa, Anderson Schwingel Ribeiro, Claiton Leoneti Lencina, Francieli Moro Stefanello, Roselia Maria Spanevello
Bipolar disorder is a psychiatric disease characterized by recurrent episodes of mania and depression. Blueberries contain bioactive compounds with important pharmacological effects such as neuroprotective and antioxidant actions. The aim of this study was to investigate the effects of blueberry extract and/or lithium on oxidative stress, and acetylcholinesterase (AChE) and Na+ , K+ -ATPase activity in an experimental ketamine-induced model of mania. Male Wistar rats were pretreated with vehicle, blueberry extract (200 mg/kg), and/or lithium (45 mg/kg or 22...
December 7, 2018: Metabolic Brain Disease
Josiah Tatenda Masuka, Garikai Muzopambwa, Star Khoza, Dixon Chibanda
A 29-year-old Black female patient was admitted to a psychiatric ward with symptoms of major depressive disorder with psychosis. The patient was started on amitriptyline 50 mg/day and haloperidol 10 mg/day. On day 4 post-admission, the preferred first-line antidepressant, fluoxetine, became available and the patient was switched from amitriptyline to fluoxetine 20 mg/day. On the same day, the dose of haloperidol was reduced to 5 mg/day. Thirteen days post-initiation of these medications the patient became talkative, associated with emotional lability, an expansive mood, irritability and restlessness...
December 10, 2018: Drug Safety—Case Reports
Anne Duffy, Sarah Goodday, Charles Keown-Stoneman, Paul Grof
OBJECTIVE: The authors sought to describe the emergent course of bipolar disorder in offspring of affected parents subgrouped by parental response to lithium prophylaxis. METHODS: Parent bipolar disorder was confirmed by the best-estimate procedure and lithium response by research protocol. High-risk offspring (N=279) and control subjects (N=87) were blindly assessed, annually on average, with the Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime version or the Schedule for Affective Disorders and Schizophrenia-Lifetime version...
December 11, 2018: American Journal of Psychiatry
Ibrahim Jawad, Stuart Watson, Peter M Haddad, Peter S Talbot, R Hamish McAllister-Williams
A number of effective maintenance medication options exist for bipolar disorder (BD) and these are regarded as the foundation of long-term treatment in BD. However, nonadherence to medication is common in BD. For example, a large data base study in the United States of America (USA) showed that approximately half of patients with BD were nonadherent with lithium and maintenance medications over a 12 month period. Such nonadherence carries a high risk of relapse due to the recurrent nature of the illness and the fact that abrupt cessation of treatment, particularly lithium, may cause rebound depression and mania...
December 2018: Therapeutic Advances in Psychopharmacology
Michael J McCarthy, Heather Wei, Caroline M Nievergelt, Andrea Stautland, Adam X Maihofer, David K Welsh, Paul Shilling, Martin Alda, Ney Alliey-Rodriguez, Amit Anand, Ole A Andreasson, Yokesh Balaraman, Wade H Berrettini, Holli Bertram, Kristen J Brennand, Joseph R Calabrese, Cynthia V Calkin, Ana Claasen, Clara Conroy, William H Coryell, David W Craig, Nicole D'Arcangelo, Anna Demodena, Srdjan Djurovic, Scott Feeder, Carrie Fisher, Nicole Frazier, Mark A Frye, Fred H Gage, Keming Gao, Julie Garnham, Elliot S Gershon, Kara Glazer, Fernando Goes, Toyomi Goto, Gloria Harrington, Petter Jakobsen, Masoud Kamali, Elizabeth Karberg, Marisa Kelly, Susan G Leckband, Falk Lohoff, Melvin G McInnis, Francis Mondimore, Gunnar Morken, John I Nurnberger, Sarah Obral, Ketil J Oedegaard, Abigail Ortiz, Megan Ritchey, Kelly Ryan, Martha Schinagle, Helle Schoeyen, Candice Schwebel, Martha Shaw, Tatyana Shekhtman, Claire Slaney, Emma Stapp, Szabolcs Szelinger, Bruce Tarwater, Peter P Zandi, John R Kelsoe
Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, but only a minority of patients fully respond to monotherapy. Presently, we hypothesized that lithium-responsive BD patients (Li-R) would show characteristic differences in chronotype and cellular circadian rhythms compared to lithium non-responders (Li-NR). Selecting patients from a prospective, multi-center, clinical trial of lithium monotherapy, we examined morning vs...
November 16, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Rebecca Strawbridge, Ben Carter, Lindsey Marwood, Borwin Bandelow, Dimosthenis Tsapekos, Viktoriya L Nikolova, Rachael Taylor, Tim Mantingh, Valeria de Angel, Fiona Patrick, Anthony J Cleare, Allan H Young
BACKGROUND: Depression is considered to have the highest disability burden of all conditions. Although treatment-resistant depression (TRD) is a key contributor to that burden, there is little understanding of the best treatment approaches for it and specifically the effectiveness of available augmentation approaches.AimsWe conducted a systematic review and meta-analysis to search and quantify the evidence of psychological and pharmacological augmentation interventions for TRD. METHOD: Participants with TRD (defined as insufficient response to at least two antidepressants) were randomised to at least one augmentation treatment in the trial...
January 2019: British Journal of Psychiatry: the Journal of Mental Science
Markus Dold, Lucie Bartova, Alexander Kautzky, Alessandro Serretti, Stefano Porcelli, Daniel Souery, Julien Mendlewicz, Stuart Montgomery, Joseph Zohar, Siegfried Kasper
This cross-sectional European multicenter study with retrospective assessment of treatment response sought to determine variables associated with the administration of augmentation strategies with second-generation antipsychotics (SGAs) and lithium in the pharmacotherapy of major depressive disorder (MDD). In 349 DSM-IV-TR MDD patients, differences in socio-demographic, clinical, treatment, and pharmacological features between participants receiving add-on treatment of their antidepressants with either SGAs (n = 318) or lithium (n = 31) were investigated using analyses of covariance, chi-squared tests, and binary logistic regression analyses...
November 13, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Ida Behrendt-Møller, Trine Madsen, Holger Jelling Sørensen, Louisa Sylvia, Edward S Friedman, Richard C Shelton, Charles L Bowden, Joseph R Calabrese, Susan L McElroy, Terence A Ketter, Noreen A Reilly Harrington, Keming Gao, Michael Thase, William V Bobo, Mauricio Tohen, Melvin McInnis, Masoud Kamali, James H Kocsis, Thilo Deckersbach, Ole Köhler-Forsberg, Andrew A Nierenberg
INTRODUCTION: Depressive episodes are often prevalent among patients with bipolar disorder, but little is known regarding the differential patterns of development over time. We aimed to determine and characterize trajectories of depressive symptoms among adults with bipolar disorder during 6 months of systematic treatment. METHOD: The pragmatic clinical trial, Bipolar Clinical Health Outcomes Initiative in Comparative Effectiveness (CHOICE) randomized 482 outpatients with bipolar disorder to lithium or quetiapine...
November 1, 2018: Bipolar Disorders
Xiuli Wang, Qiang Luo, Fangfang Tian, Bochao Cheng, Lihua Qiu, Song Wang, Manxi He, Hongming Wang, Mingjun Duan, Zhiyun Jia
Background: The literature on grey-matter volume alterations in bipolar disorder is heterogeneous in its findings. Methods: Using effect-size differential mapping, we conducted a meta-analysis of grey-matter volume alterations in patients with bipolar disorder compared with healthy controls. Results: We analyzed data from 50 studies that included 1843 patients with bipolar disorder and 2289 controls. Findings revealed lower grey-matter volumes in the bilateral superior frontal gyri, left anterior cingulate cortex and right insula in patients with bipolar disorder and in patients with bipolar disorder type I...
October 24, 2018: Journal of Psychiatry & Neuroscience: JPN
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