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Lithium Depression

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https://www.readbyqxmd.com/read/30383333/patterns-of-changes-in-bipolar-depressive-symptoms-revealed-by-trajectory-analysis-among-482-patients-with-bipolar-disorder
#1
Ida Behrendt-Møller, Trine Madsen, Holger Jelling Sørensen, Louisa Sylvia, Edward S Friedman, Richard C Shelton, Charles L Bowden, Joseph R Calabrese, Susan L McElroy, Terence A Ketter, Noreen A Reilly Harrington, Keming Gao, Michael Thase, William V Bobo, Mauricio Tohen, Melvin McInnis, Masoud Kamali, James H Kocsis, Thilo Deckersbach, Ole Köhler-Forsberg, Andrew A Nierenberg
INTRODUCTION: Depressive episodes are often prevalent among patients with bipolar disorder, but little is known regarding the differential patterns of development over time. We aimed to determine and characterize trajectories of depressive symptoms among adults with bipolar disorder during 6 months of systematic treatment. METHOD: The pragmatic clinical trial, Bipolar Clinical Health Outcomes Initiative in Comparative Effectiveness (CHOICE) randomized 482 outpatients with bipolar disorder to lithium or quetiapine...
November 1, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/30354038/brain-grey-matter-volume-alteration-in-adult-patients-with-bipolar-disorder-under-different-conditions-a-voxel-based-meta-analysis
#2
Xiuli Wang, Qiang Luo, Fangfang Tian, Bochao Cheng, Lihua Qiu, Song Wang, Manxi He, Hongming Wang, Mingjun Duan, Zhiyun Jia
Background: The literature on grey-matter volume alterations in bipolar disorder is heterogeneous in its findings. Methods: Using effect-size differential mapping, we conducted a meta-analysis of grey-matter volume alterations in patients with bipolar disorder compared with healthy controls. Results: We analyzed data from 50 studies that included 1843 patients with bipolar disorder and 2289 controls. Findings revealed lower grey-matter volumes in the bilateral superior frontal gyri, left anterior cingulate cortex and right insula in patients with bipolar disorder and in patients with bipolar disorder type I...
October 24, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30336492/glutamate-related-antibodies-and-peripheral-insulin-like-growth-factor-in-bipolar-disorder-and-lithium-prophylaxis
#3
Ewa Ferensztajn-Rochowiak, Mariusz Kaczmarek, Marlena Wójcicka, Elzbieta Kaufman-Szukalska, Sebastian Dziuda, Agnieszka Remlinger-Molenda, Agnieszka Szeliga-Neymann, Jacek Losy, Janusz K Rybakowski
AIMS: The aim of this study was to evaluate serum levels of the antineuronal antibodies anti-N-methyl-D-aspartate receptor (NMDAR) and anti-glutamic acid decarboxylase (GAD), and insulin-like growth factor 1 (IGF-1), in patients with bipolar disorder (BD), during manic and depressive episodes and in remission compared to euthymic patients receiving long-term lithium therapy. METHODS: Serum levels of anti-NMDAR and anti-GAD 450/620 antibodies, as well as IGF-1, were measured using the ELISA method in 19 manic and 17 depressed patients both in an acute episode and in remission after the episode...
October 18, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/30319463/imaging-habenula-volume-in-schizophrenia-and-bipolar-disorder
#4
Matthew Schafer, Joo-Won Kim, Joshmi Joseph, Junqian Xu, Sophia Frangou, Gaelle E Doucet
The habenula (Hb), a bilateral nucleus located next to the dorsomedial thalamus, is of particular relevance to psychiatric disorders based on preclinical evidence linking the Hb to depressive and amotivational states. However, studies in clinical samples are scant because segmentation of the Hb in neuroimaging data is challenging due to its small size and low contrast from the surrounding tissues. Negative affective states dominate the clinical course of schizophrenia and bipolar disorder and represent a major cause of disability...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30316147/bipolar-disorder-mixed-episodes-a-pragmatic-trial-of-a-public-health-treatment-effectiveness
#5
Sandro René P S Miguel, Ana Flávia B S Lima, Luciane N Cruz, Mírian Cohen, Jacques J Zimmermann, Patrícia K Ziegelmann, Marcelo P A Fleck
OBJECTIVES: To evaluate the effectiveness of an algorithm for the treatment of mixed episodes in bipolar disorder (BD) using the medications available under the Unified Health System (Sistema Único de Saúde) in Brazil. METHODS: The study included 107 individuals with BD in a current mixed episode, assessed biweekly for the outcomes of response and remission. The subjects were randomly assigned to start treatment with lithium, valproic acid, or carbamazepine, following a clinical protocol at a public outpatient clinic...
October 10, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/30246666/timing-of-onset-of-lithium-relapse-prevention-in-bipolar-disorder-evidence-from-randomised-trials
#6
Matthew J Taylor
SummaryLithium is widely prescribed, but the timing of key effects remains uncertain. The timing of onset of its relapse prevention effects is clarified by placebo-controlled randomised trials (3 studies, n = 1120). Lithium reduced relapse into any mood episode over the first 2 weeks of treatment (hazard ratio 0.40, 95% CI 0.16-0.97). Fewer manic relapses were evident within the first 4 weeks, however, early effects on depressive relapse were not demonstrated. There is an early onset of lithium relapse prevention effects in bipolar disorder, particularly against manic relapse...
November 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/30243822/mycophenolate-mofetil-contributes-to-downregulation-of-the-hippocampal-interleukin-type-2-and-1%C3%AE-mediated-pi3k-akt-mtor-pathway-hyperactivation-and-attenuates-neurobehavioral-comorbidities-in-a-rat-model-of-temporal-lobe-epilepsy
#7
Arindam Ghosh Mazumder, Vikram Patial, Damanpreet Singh
The role of neuroinflammatory mediators has been well established in the pathogenesis of temporal lobe epilepsy (TLE) and associated neurobehavioral comorbidities. Mycophenolate mofetil (MMF) is commonly used as an immunosuppressant in organ transplantations. Its neuroprotective effect is well explored in different preclinical and clinical studies. The present study was designed to investigate the effect of MMF in rat model of lithium pilocarpine (LiPc)-induced spontaneous recurrent seizures and its associated neurobehavioral comorbidities...
September 20, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/30243681/can-lithium-salts-prevent-depressive-episodes-in-the-real-world
#8
Ana González-Pinto, Purificación López-Peña, Cristina Bermúdez-Ampudia, Eduard Vieta, Mónica Martinez-Cengotitabengoa
To critically examine the effectiveness of lithium in preventing depressive symptoms (mixed and depressive episodes) in real life settings, taking into account adherence to drug treatment and its implications for the clinical costs of the disease. Overall, 72 patients with bipolar disorder initially treated with lithium carbonate were included and followed-up for 10 years. Patients were assessed every 8 weeks for morbidity and alcohol/drug consumption. Patients with good adherence to lithium had fewer episodes with depressive features than poor adherers (B = 2...
September 20, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30234617/movement-disorders-after-exposure-to-antipsychotic-drugs-in-patients-with-depressive-disorders
#9
María Verónica Rey, Luis Molina, Byron Recinos, Bezner Paz, Mauricio Rovelo, Fanny Elizabeth Rodriguez Elias, José Calderón, Arturo Arellano, Santiago Perez-Lloret
OBJECTIVES: The aims of the study were to explore the frequency of movement disorders (MDs) in depressive patients exposed to antipsychotic drugs (APDs) and to compare it with nonexposed depressive patients and APDs-treated schizophrenic patients. METHODS: Four hundred fifty-two depressive patients not exposed to APDs (group A), 156 depressives exposed to APDs (group B), and 75 patients with schizophrenia on APDs (group C) were recruited. Presence of MDs was explored by the Simpson-Angus and UKU scales (Registration: NCT02409823)...
September 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/30193142/severe-hair-loss-associated-with-psychotropic-drugs-in-psychiatric-inpatients-data-from-an-observational-pharmacovigilance-program-in-german-speaking-countries
#10
Katrin Druschky, Stefan Bleich, Renate Grohmann, Katharina Burda, Helge Frieling, Thomas Hillemacher, Alexandra Neyazi, Susanne Stübner, Sermin Toto
BACKGROUND: The study aimed to investigate severe hair loss related to psychotropic drugs (PDs) by using data from the drug safety programme Arzneimittelsicherheit in der Psychiatrie (AMSP). METHODS: Data on PD utilization and reports of severe PD-related hair loss were collected in 83 psychiatric hospitals in Austria, Germany and Switzerland during the period 1993-2013. RESULTS: Out of 432,215 patients under surveillance, 404,009 patients were treated with PDs for the main indications of depression, schizophrenic disorder, neurosis, mania, and organic psychosis...
October 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/30187288/a-review-of-the-pharmacological-and-clinical-profile-of-newer-atypical-antipsychotics-as-treatments-for-bipolar-disorder-considerations-for-use-in-older-patients
#11
REVIEW
Akshya Vasudev, Sumit Chaudhari, Rickinder Sethi, Rachel Fu, Rachel M Sandieson, Brent P Forester
Bipolar disorder prevalence rates vary in the older adult population (defined as age ≥ 65 years), ranging from 1% in community dwellers to as high as 8-10% in hospital inpatients. Although older agents, including lithium and valproic acid, offer significant antimanic efficacy, as supported by a recent randomized controlled trial (RCT), there is growing interest in using atypical antipsychotics to treat bipolar disorder in older adults. Newer atypical antipsychotics are of interest based on their tolerability and efficacy in the general adult bipolar population...
October 2018: Drugs & Aging
https://www.readbyqxmd.com/read/30182841/lithium-pharmacological-and-toxicological-aspects-the-current-state-of-the-art
#12
Branislava Medić, Marko Stojanović, Bojan Štimec, Nevena Divac, Katarina Savić Vujović, Radan Stojanović, Mirjana Čolović, Danijela Z Krstić, Milica Prostran
Lithium is the smallest monovalent cation with many different biological effects. Although lithium is present in pharmacotherapy of psychiatric illnesses for decades, its precise mechanism of action is still not clarified. Today lithium represents first-line therapy for bipolar disorders (because it possesses both antimanic and antidepressant properties) and the adjunctive treatment for major depression (due to its antisuicidal effects). Beside, lithium showed some protective effects in neurological diseases including acute neural injury, chronic degenerative conditions, Alzheimer's disease as well as in treating leucopenia, hepatitis and some renal diseases...
September 4, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/30179154/erbb4-deletion-in-noradrenergic-neurons-in-the-locus-coeruleus-induces-mania-like-behavior-via-elevated-catecholamines
#13
Shu-Xia Cao, Ying Zhang, Xing-Yue Hu, Bin Hong, Peng Sun, Hai-Yang He, Hong-Yan Geng, Ai-Min Bao, Shu-Min Duan, Jian-Ming Yang, Tian-Ming Gao, Hong Lian, Xiao-Ming Li
Dysfunction of the noradrenergic (NE) neurons is implicated in the pathogenesis of bipolar disorder (BPD). ErbB4 is highly expressed in NE neurons, and its genetic variation has been linked to BPD; however, how ErbB4 regulates NE neuronal function and contributes to BPD pathogenesis is unclear. Here we find that conditional deletion of ErbB4 in locus coeruleus (LC) NE neurons increases neuronal spontaneous firing through NMDA receptor hyperfunction, and elevates catecholamines in the cerebrospinal fluid (CSF)...
September 4, 2018: ELife
https://www.readbyqxmd.com/read/30178205/biochemical-properties-and-catalytic-specificity-of-a-novel-neutral-serine-peptidase-secreted-by-fungus-pyrenochaetopsis-sp
#14
Ronivaldo Rodrigues da Silva, Nathalia Gonsales da Rosa, Lilian Caroline Gonçalves de Oliveira, Maria Aparecida Juliano, Luiz Juliano, Jose C Rosa, Hamilton Cabral
The fungal genus Pyrenochaetopsis has received particular attention because of its different lifestyles, such as numerous plant pathogenic, saprophytic, and endophytic species. Its ability to infect plant cells relies heavily upon secreted peptidases. Here, we investigated the biochemical properties and catalytic specificity of a new serine peptidase secreted by the filamentous fungus Pyrenochaetopsis sp. We found that while this neutral serine peptidase displayed optimal activity at a pH of 7.0 and temperature of 45 °C, it tolerated a wide range of pH conditions and temperatures lower than 45 °C...
September 4, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/30158262/use-of-cinacalcet-in-lithium-induced-hyperparathyroidism
#15
Michael Dixon, Vikram Luthra, Christopher Todd
The case of a 61-year-old female patient with a long-standing history of bipolar affective disorder treated medically with lithium therapy for the past two decades. In late 2012, the patient was diagnosed with hyperparathyroidism secondary to lithium therapy. The patient underwent parathyroidectomy in August 2013. During surgery, only two glands were conclusively located and removed. This resulted in a reduction in the patient's plasma total calcium levels and parathyroid hormone. The psychiatric management of the bipolar affective disorder was reviewed, and lithium discontinued as a result of the findings...
August 29, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30149276/differential-response-to-lithium-between-melancholic-and-non-melancholic-unipolar-depression
#16
Marina P Valerio, Diego J Martino
The purpose of this report was to review the evidence regarding the differential response to lithium treatment between patients with unipolar melancholic and non-melancholic depression. Three studies suggest that the prophylactic effect of lithium in maintenance treatment may be greater in melancholic depression. Another study reported that melancholic symptoms, such as weight loss and psychomotor disturbances, predict a better response to lithium augmentation. These preliminary data suggest that the response to lithium may be greater in melancholic than in non-melancholic depression, which could be the focus of further research...
November 2018: Psychiatry Research
https://www.readbyqxmd.com/read/30142397/nociceptin-orphanin-fq-receptor-agonists-increase-aggressiveness-in-the-mouse-resident-intruder-test
#17
Epifanio F Silva, Aldemara I Silva, Laila Asth, Lisiane S Souza, Nurulain T Zaveri, Remo Guerrini, Girolamo Calo', Chiara Ruzza, Elaine C Gavioli
Aggressive behaviors can be considered symptoms of bipolar disorder, schizophrenia, post-traumatic stress, intermittent explosive, and personality disorders. Nociceptin/orphanin FQ (N/OFQ) is a peptide acting as endogenous ligand of the NOP receptor. Preclinical and clinical findings suggest the NOP receptor as an innovative target for the treatment of psychopathologies, such as anxiety, depression, and drug abuse. This study investigated the effects of NOP ligands and the behavioral phenotype of mice lacking the NOP receptor in an animal model of aggressiveness, the resident-intruder test...
January 1, 2019: Behavioural Brain Research
https://www.readbyqxmd.com/read/30130372/monitoring-of-somatic-parameters-at-outpatient-departments-for-mood-and-anxiety-disorders
#18
Mirjam Simoons, Hans Mulder, Bennard Doornbos, Robert A Schoevers, Eric N van Roon, Henricus G Ruhé
INTRODUCTION: Somatic complications account for the majority of the 13-30 years shortened life expectancy in psychiatric patients compared to the general population. The study aim was to assess to which extent patients visiting outpatient departments for mood and anxiety disorders were monitored for relevant somatic comorbidities and (adverse) effects of psychotropic drugs-more specifically a) metabolic parameters, b) lithium safety and c) ECGs-during their treatment. METHODS: We performed a retrospective clinical records review and cross-sectional analysis to assess the extent of somatic monitoring at four outpatient departments for mood and anxiety disorders in The Netherlands...
2018: PloS One
https://www.readbyqxmd.com/read/30102627/a-pilot-study-of-the-effectiveness-of-lithium-versus-quetiapine-immediate-release-monotherapy-in-patients-with-bipolar-spectrum-disorders
#19
Keming Gao, Toyomi Goto, Chengmei Yuan, Brittany Brownrigg, Carla Conroy, Philip K Chan, Mary Beth Serrano, Stephen J Ganocy, Fang Fang, Joseph R Calabrese
OBJECTIVE: The aim of this study was to compare the effectiveness of lithium versus quetiapine immediate release (IR) monotherapy in patients with bipolar I, II, or subthreshold bipolar disorder at any phase. METHODS: Eligible patients were randomized to lithium or quetiapine IR for 16 weeks. The difference in the time to discontinuation from study due to "all causes" between lithium and quetiapine IR groups and changes from baseline to 8 and 16 weeks in depression, mania, anxiety, quality of life (QOL), metabolic profiles, and proinflammatory markers were compared...
October 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30092919/pharmacologic-treatment-of-perinatal-depression
#20
REVIEW
Mary C Kimmel, Elizabeth Cox, Crystal Schiller, Edith Gettes, Samantha Meltzer-Brody
This review provides information about medications used to treat perinatal depression, including guidance around when to use certain medications and when to consult a mental health provider. For each group of medications, including selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, mirtazapine, bupropion, lithium, atypical antipsychotics, and lamotrigine, the risks and benefits of treatment during pregnancy and lactation are reviewed, and unique qualities of each medication...
September 2018: Obstetrics and Gynecology Clinics of North America
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