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https://www.readbyqxmd.com/read/30323028/characterization-of-host-responses-during-pseudomonas-aeruginosa-acute-lung-infection-in-the-lungs-and-blood-and-after-treatment-with-the-synthetic-immunomodulatory-peptide-idr-1002
#1
Kelli Wuerth, Amy H Y Lee, Reza Falsafi, Erin E Gill, Robert E W Hancock
Pseudomonas aeruginosa is an opportunistic pathogen that causes nosocomial pneumonia and infects patients with cystic fibrosis. P. aeruginosa lung infections are difficult to treat due to bacterial resistance to antibiotics, and strains with multi-drug resistance are becoming more prevalent. Here we examined the use of a small host defense peptide, innate defense regulator 1002 (IDR-1002), in an acute P. aeruginosa lung infection in vivo. IDR-1002 significantly reduced the bacterial burden in the bronchoalveolar lavage fluid (BALF) as well as MCP-1 in the BALF and serum, KC in the serum, and IL-6 in the BALF...
October 15, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/30322853/pyrimidine-biosynthesis-regulates-small-colony-variant-and-mucoidy-in-pseudomonas-aeruginosa-through-sigma-factor-competition
#2
Roy Al Ahmar, Brandon D Kirby, Hongwei D Yu
Mucoidy due to alginate overproduction by the Gram-negative bacterium Pseudomonas aeruginosa facilitates chronic lung infections in patients with Cystic Fibrosis (CF). We previously reported that disruption in de novo synthesis of pyrimidines resulted in conversion to a non-mucoid small colony variant (SCV) in the mucoid P. aeruginosa strain (PAO581), which has a truncated anti-sigma factor MucA25 that cannot sequester sigma factor AlgU/T. Here we showed that supplementation with the nitrogenous bases uracil or cytosine in growth medium complemented SCV to normal growth, and non-mucoidy to mucoidy in these mucA25 mutants...
October 15, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/30321487/cardiopulmonary-exercise-testing-provides-additional-prognostic-information-in-cystic-fibrosis
#3
Helge Hebestreit, Erik Hj Hulzebos, Jane E Schneiderman, Chantal Karila, Steven R Boas, Susi Kriemler, Tiffany Dwyer, Margareta Sahlberg, Don S Urquhart, Larry C Lands, Felix Ratjen, Tim Takken, Liobou Varanistkaya, Viktoria Rücker, Alexandra Hebestreit, Jakob Usemann, Thomas Radtke
RATIONALE: The prognostic value of cardiopulmonary exercise testing (CPET) for survival in cystic fibrosis (CF) in the context of current clinical management, when controlling for other known prognostic factors is unclear. OBJECTIVES: To determine the prognostic value of CPET-derived measures beyond peak oxygen uptake (VO2peak) following rigorous adjustment for other predictors. MEASUREMENTS AND MAIN RESULTS: Data from 10 CF-centers in Australia, Europe and North America were collected retrospectively...
October 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30320743/identification-of-virulence-markers-of-mycobacterium-abscessus-for-intracellular-replication-in-phagocytes
#4
Violaine Dubois, Laura Laencina, Anouchka Bories, Vincent Le Moigne, Alexandre Pawlik, Jean-Louis Herrmann, Fabienne Girard-Misguich
What differentiates Mycobacterium abscessus from other saprophytic mycobacteria is the ability to resist phagocytosis by human macrophages and the ability to multiply inside such cells. These virulence traits render M. abscessus pathogenic, especially in vulnerable hosts with underlying structural lung disease, such as cystic fibrosis, bronchiectasis or tuberculosis. How patients become infected with M. abscessus remains unclear. Unlike many mycobacteria, M. abscessus is not found in the environment but might reside inside amoebae, environmental phagocytes that represent a potential reservoir for M...
September 27, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30319824/cystic-echinococcosis-of-the-bone-in-kazakhstan
#5
Tommaso Manciulli, Aigerim Mustapayeva, Konrad Juszkiewicz, Ekaterina Sokolenko, Zhaksylik Maulenov, Ambra Vola, Mara Mariconti, Gani Serikbaev, Amangul Duisenova, Enrico Brunetti, Zhamilya Zholdybay
Cystic echinococcosis (CE) is a parasitic zoonosis caused by E. granulosus primarily affecting the liver and lungs. CE of the bone is by far the most debilitating form of the disease and is very difficult to manage as it mimics malignant tumors. We reviewed bone CE cases admitted to a reference oncological hospital in Kazakhstan from January 2010 to February 2017. Among eight patients, the mean age was 33.5 years, and the male/female ratio was 1 : 3. Patients were examined by X-ray (8/8), CT (7/8), and MRI (3/8)...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/30318010/inhaled-biologicals-for-the-treatment-of-cystic-fibrosis
#6
Valentina Sala, Alessandra Murabito, Alessandra Ghigo
BACKGROUND: Cystic Fibrosis, one of the most frequent genetic diseases, is characterized by the production of viscous mucus in several organs. In the lungs, mucus clogs the airways and traps bacteria, leading to recurrent/resistant infections and lung damage. For Cystic Fibrosis patients, respiratory failure is still lethal in early adulthood since available treatments display incomplete efficacy. OBJECTIVE: The objective of this review is to extend the current knowledge in the field of available treatments for Cystic Fibrosis...
October 11, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/30317832/unexpected-false-positive-i-131-uptake-in-patients-with-differentiated-thyroid-carcinoma
#7
Aylin Oral, Bülent Yazıcı, Cenk Eraslan, Zeynep Burak
Objective: Radioiodine is the most specific radionuclide for differentiated thyroid carcinoma (DTC) imaging. Despite its high specificity and sensitivity, false-positive I-131 uptake could be seen on whole body scan (WBS) that may lead to misdiagnosis and unnecessary radioiodine treatment. In this study, we aimed to present the I-131 WBS and concomitant single photon emission computed tomography/computed tomography (SPECT/CT) images of unexpected false-positive radioiodine uptake along with the patients’ clinical outcomes and the contribution of SPECT/CT imaging...
October 9, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/30316849/decontamination-and-lung-transplantation-of-a-cystic-fibrosis-patient-with-resistant-infections
#8
Aakash Shah, Chetan Pasrija, Francesca Boulos, Si Pham, Bartley P Griffith, Anthony Amoroso, Pablo G Sanchez, Zachary N Kon
We describe the use of a decontamination protocol that allowed for successful lung transplantation in a cystic fibrosis patient with necrotizing pneumonia from highly antibiotic-resistant pathogens (Burkholderia and psuedomonas species). This strategy may allow for successful lung transplantation in cystic fibrosis patients with multi-drug resistant infections previously considered non-transplantable.
October 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30315800/the-risk-of-misdiagnosing-pulmonary-adenocarcinoma-as-traumatic-pseudocyst-in-a-young-adult
#9
Mitsuhiro Kamiyoshihara, Ryohei Yoshikawa, Hitoshi Igai, Fumi Ohsawa, Tomohiro Yazawa
A 35-year-old male was transferred because of bruising on the chest. A computed tomography scan revealed a pulmonary pseudocyst. Although the pulmonary pseudocyst remained unchanged it accumulated fluid. Based on our concern regarding hemoptysis, the patient underwent S6 segmentectomy of the right lower lobe. The postoperative pathological examination revealed a cystic lesion, including a white mass on the cystic wall. Unexpectedly, the mass was composed of papillary adenocarcinoma. Acute care surgeons should be alert to the possible presence of tumor in trauma patients...
October 10, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30315749/intermittent-inhaled-tobramycin-and-systemic-cytokines-response-in-cf-patients-with-pseudomonas-aeruginosa
#10
Yazeed Toukan, Michal Gur, Fahed H Hakim, Yuval Geffen, Ronen Bar-Yoseph, Vered Nir, Lea Bentur
INTRODUCTION: CF pulmonary guidelines recommend alternate therapy (one month on, one month off) with inhaled tobramycin for chronic Pseudomonas aeruginosa colonization in cystic fibrosis (CF). Tobramycin-inhaled powder (TIP™) is increasingly replacing time-consuming nebulizer therapy. It is unclear whether laboratory parameters change during the month off period compared with the month on therapy. PURPOSE: Our aim was to assess whether spirometry, lung clearance index and circulating inflammatory markers differ between on/off treatment periods...
September 30, 2018: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/30312663/relationship-between-diabetes-and-respiratory-diseases-clinical-and-therapeutic-aspects
#11
REVIEW
D Visca, P Pignatti, A Spanevello, E Lucini, E La Rocca
Diabetes is a common metabolic disorder affecting the entire body with high morbidity and mortality worldwide. The major complications related to diabetes are mostly due to the macrovascular and microvascular bed impairment due to metabolic, hemodynamic and inflammatory factors. However, studies over the past decades have added also the lung as a target organ in both type 1 and type 2 diabetes. Diabetes has always been addressed as a major comorbidity conditioning the disease behaviour and the natural history of several respiratory diseases...
October 9, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30312551/cystic-fibrosis-emerging-understanding-and-therapies
#12
Michael M Rey, Michael P Bonk, Denis Hadjiliadis
Cystic fibrosis (CF) is the most common life-limiting genetic disease in Caucasian patients. Continued advances have led to improved survival, and adults with CF now outnumber children. As our understanding of the disease improves, new therapies have emerged that improve the basic defect, enabling patient-specific treatment and improved outcomes. However, recurrent exacerbations continue to lead to morbidity and mortality, and new pathogens have been identified that may lead to worse outcomes. In addition, new complications, such as CF-related diabetes and increased risk of gastrointestinal cancers, are creating new challenges in management...
October 12, 2018: Annual Review of Medicine
https://www.readbyqxmd.com/read/30311545/pulmonary-function-patterns-and-their-association-with-genotype-and-phenotype-in-adult-cystic-fibrosis-patients
#13
Dimitri Stylemans, Sylvia Verbanck, Stefanie Vincken, Walter Vincken, Elke De Wachter, Eef Vanderhelst
BACKGROUND: While cystic fibrosis (CF) lung disease is generally considered to be an obstructive disorder, other pulmonary function patterns (PFP) may occur. Furthermore, little is known about possible associations between PFP and genotype or phenotypical characteristics. METHODS: Cross-sectional study including CF patients aged 16 years or more, identifying different PFP and exploring associations between PFP and genotype or phenotypical characteristics. RESULTS: Obstructive PFP was most prevalent in our population (n = 80), comprising obstructive lung disease (62...
October 12, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/30307979/analysis-of-a-large-cohort-of-cystic-fibrosis-patients-with-severe-liver-disease-indicates-lung-function-decline-does-not-significantly-differ-from-that-of-the-general-cystic-fibrosis-population
#14
Deepika Polineni, Annalisa V Piccorelli, William B Hannah, Sarah N Dalrymple, Rhonda G Pace, Peter R Durie, Simon C Ling, Michael R Knowles, Jaclyn R Stonebraker
Previous reports of lung function in cystic fibrosis (CF) patients with liver disease have shown worse, similar, or even better forced expiratory volume in 1 second (FEV1), compared to CF patients without liver disease. Varying definitions of CF liver disease likely contribute to these inconsistent relationships reported between CF lung function and liver disease. We retrospectively evaluated spirometric data in 179 subjects (62% male; 58% Phe508del homozygous) with severe CF liver disease (CFLD; defined by presence of portal hypertension due to cirrhosis)...
2018: PloS One
https://www.readbyqxmd.com/read/30306206/a-review-of-inflammatory-mechanism-in-airway-diseases
#15
REVIEW
Parya Aghasafari, Uduak George, Ramana Pidaparti
BACKGROUND: Inflammation in the lung is the body's natural response to injury. It acts to remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the healing process. Acute and chronic pulmonary inflammation are seen in different respiratory diseases such as; acute respiratory distress syndrome, chronic obstructive pulmonary disease (COPD), asthma, and cystic fibrosis (CF). FINDINGS: In this review, we found that inflammatory response in COPD is determined by the activation of epithelial cells and macrophages in the respiratory tract...
October 10, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30306073/molecular-basis-of-cystic-fibrosis-from-bench-to-bedside
#16
REVIEW
Maria Cristina Dechecchi, Anna Tamanini, Giulio Cabrini
Cystic fibrosis (CF), is an autosomal recessive disease affecting different organs. The lung disease, characterized by recurrent and chronic bacterial infection and inflammation since infancy, is the main cause of morbidity and precocious mortality of these individuals. The innovative therapies directed to repair the defective CF gene should account for the presence of more than 200 disease-causing mutations of the CF transmembrane conductance regulator ( CFTR ) gene. The review will recall the different experimental approaches in discovering CFTR protein targeted molecules, such as the high throughput screening on chemical libraries to discover correctors and potentiators of CFTR protein, dual-acting compounds, read-through molecules, splicing defects repairing tools, CFTR "amplifiers"...
September 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30305982/fetal-congenital-peripheral-bronchial-atresia-diagnosed-by-magnetic-resonance-imaging-two-case-reports
#17
Mitsuru Kozaki, Yuko Iraha, Hitoshi Masamoto, Hayase Nitta, Yukiko Chinen, Tadatsugu Kinjo, Keiko Mekaru, Yoichi Aoki
Two types of congenital bronchial atresia (proximal and peripheral) have been classified. We report two cases of peripheral bronchial atresia diagnosed by prenatal ultrasonography (US) and magnetic resonance imaging (MRI). Evaluating an enlarged lung mass that is homogeneously hyperechoic on US and hyperintense on T2-weighted MRI can help in determining whether bronchial atresia is present. Proximal type is suggested when a dilated main bronchus is observed as a tubule structure of an involved lung hilum. In our cases, T2-weighted MRI revealed homogeneously hyperintense lung lesion with decreased signal intensity of adjacent lobe, flattening diaphragm, and mediastinal shift...
October 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/30305925/effects-of-exercise-training-on-physical-and-psychosocial-health-in-children-with-chronic-respiratory-disease-a-systematic-review-and-meta-analysis
#18
Barbara Joschtel, Sjaan R Gomersall, Sean Tweedy, Helen Petsky, Anne B Chang, Stewart G Trost
Introduction: Chronic disease in children is increasing, including the prevalence of chronic respiratory diseases such as asthma, cystic fibrosis (CF), bronchiectasis and bronchopulmonary dysplasia (BPD). The aim of this systematic review and meta-analysis was to evaluate the effects of exercise training on health outcomes in children with chronic respiratory disease. Method: Five databases were searched for randomised controlled trials investigating the effects of exercise training on children with chronic respiratory disease...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/30305379/disseminated-cerebral-hydatid-disease-multiple-intracranial-echinococcosis
#19
Patricia Svrckova, Laura Nabarro, Peter L Chiodini, Hans Rolf Jäger
Intracranial echinococcosis is relatively uncommon and usually occurs in the context of echinococcal lesions elsewhere in the body, mostly liver and lung. Multiple intracranial lesions can result from rupture of an initial single intracranial cyst (in cystic echinococcosis) or from dissemination of systemic disease of the lung, liver or heart (cystic and alveolar echinococcosis). The two main subtypes, cystic and alveolar echinococcosis, present differently and have distinct imaging features in the brain. We discuss the presentation, imaging findings and clinical course of three cases (two cystic and one alveolar) of intracranial echinococcal disease in adults...
October 10, 2018: Practical Neurology
https://www.readbyqxmd.com/read/30305164/echinococcus-granulosus-hydatid-cyst-location-is-modified-by-fasciola-hepatica-infection-in-cattle
#20
Caroll Stoore, Constanza Andrade, Christian Hidalgo, Felipe Corrêa, Mauricio Jiménez, Marcela Hernandez, Rodolfo Paredes
BACKGROUND: Natural parasite infection occurs in wild and domestics animals with more than one parasite species at the same time, generating an infection called polyparasitism. Cystic echinococcosis reports are usually based only on infection with Echinoccocus granulosus leaving aside other internal parasitoses that could modulate both the immune response and pathogenesis of the natural infection. Fasciola hepatica is another cosmopolitan parasite in ruminants with a similar distribution to E...
October 10, 2018: Parasites & Vectors
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