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Lung immunosuppression

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https://www.readbyqxmd.com/read/30333826/enzymatic-inactivation-of-oxysterols-in-breast-tumor-cells-constraints-metastasis-formation-by-reprogramming-the-metastatic-lung-microenvironment
#1
Marta A Moresco, Laura Raccosta, Gianfranca Corna, Daniela Maggioni, Matias Soncini, Silvio Bicciato, Claudio Doglioni, Vincenzo Russo
Recent evidence indicates that immune cells contribute to the formation of tumor metastases by regulating the pre-metastatic niche. Whether tumor-derived factors involved in primary tumor formation play a role in metastasis formation is poorly characterized. Oxysterols act as endogenous regulators of lipid metabolism through the interaction with the nuclear Liver X Receptors-(LXR)α and LXRβ. In the context of tumor development, they establish a pro-tumor environment by dampening antitumor immune responses, and by recruiting pro-angiogenic and immunosuppressive neutrophils...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30333415/rheumatoid-arthritis-complicated-with-anti-melanoma-differentiation-associated-gene-5-antibody-positive-interstitial-pneumonia-a-case-report
#2
Haruki Matsumoto, Shuzo Sato, Yuya Fujita, Makiko Yashiro-Furuya, Naoki Matsuoka, Tomoyuki Asano, Hiroko Kobayashi, Hiroshi Watanabe, Kiyoshi Migita
Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are frequently detected in amyopathic dermatomyositis with rapidly progressive interstitial lung disease (RP-ILD). However, the presence of anti-MDA5 antibodies in other connective tissue diseases is not well known. We herein report a case of rheumatoid arthritis complicated with refractory anti-MDA5 antibody-positive ILD. A 75-year-old Japanese woman was referred to our hospital for refractory ILD. Serological testing was positive for anti-MDA5 antibody without any muscle or skin lesions...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30326889/successful-lung-transplantation-in-an-hiv-seropositive-patient-with-desquamative-interstitial-pneumonia-a-case-report
#3
Shaun Ong, Robert D Levy, John Yee, Nilu Partovi, Andrew Churg, Philippe Roméo, Jean Chalaoui, Roland Nador, Alissa Wright, Hélène Manganas, Christopher J Ryerson
BACKGROUND: Until recently, lung transplantation was not considered in patients with human immunodeficiency virus (HIV). HIV seropositive patients with suppressed viral loads can now expect long-term survival with the advent of highly active antiretroviral therapies (HAART); however, HIV remains a relative contraindication to lung transplantation. We describe, to our knowledge, the first HIV seropositive lung transplant recipient in Canada. We also review the literature of previously reported cases of solid-organ transplantation in patients with HIV with a focus on immunosuppression considerations...
October 16, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/30325558/functionally-impaired-tfh-cells-induce-regulatory-b-cells-and-cd14-hla-dr-cells-differentiation-in-non-small-cell-lung-cancer
#4
Liannv Qiu, Qinhua Yu, Yonglie Zhou, Sujie Zheng, Jiaojiao Tao, Qian Jiang, Guorong Yuan
Non-small cell lung cancer (NSCLC) represents one of the most common and aggressive cancers worldwide, as it typically displays irreversible progression and poor prognosis. The interaction between programmed cell death 1 (PD-1) and its ligand, PD-L1, plays important roles in tumor immunology. Follicular helper T (Tfh) cells have characteristically high PD-1 expression; thus, in the present study, we investigated the role of circulating Tfh cells and their correlation with disease-free survival after tumor resection in NSCLC...
October 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/30324974/pulmonary-manifestations-in-antisynthetase-syndrome
#5
Thouraya Ben Salem, Cherifa Abdelkafi, Mounir Lamloum, Imed Ben Ghorbel, Mohamed Habib Houman
INTRODUCTION: Pulmonary manifestations are frequent in patients with antisynthetase syndrome which is a particular form of inflammatory myopathies. AIM: The aim of this study is to describe clinical features and long term outcome of interstitial lung disease in these patients. METHODS: This is a retrospective descriptive study in an internal medicine department. Patients with antisynthetase syndrome hospitalized from 2000 to 2014 were collected...
February 2018: La Tunisie Médicale
https://www.readbyqxmd.com/read/30321194/postoperative-lymphopenia-an-independent-risk-factor-for-postoperative-pneumonia-after-lung-cancer-surgery-results-of-a-case-control-study
#6
Guillaume Dupont, Laura Flory, Jérôme Morel, Anne-Claire Lukaszewicz, Arnaud Patoir, Emilie Presles, Guillaume Monneret, Serge Molliex
OBJECTIVE: Postoperative lymphopenia has been proposed as a risk factor for postoperative infections but has never been identified as such in a multivariate analysis. Postoperative pneumonia (POP) is one of the most common complications after lung cancer surgery and is associated with a worse outcome. We aimed to evaluate the association between postoperative lymphopenia and POP after lung cancer surgery. METHODS: Patients admitted for lung cancer surgery (lobectomy, bilobectomy, or pneumonectomy) aged ≥ 18 years and with no history of an immunosuppressive state were eligible for inclusion...
2018: PloS One
https://www.readbyqxmd.com/read/30320628/an-immune-suppression-associated-ebv-positive-anaplastic-large-cell-lymphoma-with-a-braf-v600e-mutation
#7
Alejandro A Gru, Eli Williams, Jacqueline M Junkins-Hopkins
Iatrogenic lymphoproliferative disorders have been described in patients receiving immunosuppressive/immunomodulatory agents outside the transplantation setting. Novel biological agents such as TNF-α blockers and JAK-inhibitors have also proven to be effective in many disorders including rheumatoid arthritis, inflammatory bowel disease (ulcerative colitis and Crohn disease), psoriasis, and others. A significant dilemma exists in those lymphoproliferative disorders associated with immunosuppressants and rheumatologic conditions, that relies on whether the association of the process is with the medication or the underlying autoimmune condition...
October 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30320488/cd147-mediated-glucose-metabolic-regulation-contributes-to-the-predictive-role-of-18-f-fdg-pet-ct-imaging-for-egfr-tki-treatment-sensitivity-in-nsclc
#8
Xiaofeng Li, Qiang Fu, Yanjia Zhu, Jian Wang, Jianjing Liu, Xiaozhou Yu, Wengui Xu
The aim of this study is to investigate the role of CD147 in glucose metabolic regulation and its association with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment sensitivity prediction using 18 F-fluorodeoxyglucose (18 F-FDG) PET/CT imaging in non-small cell lung cancer (NSCLC). In this study, four human NSCLC cell lines with different EGFR-TKI responses were used to detect p-EGFR/EGFR and CD147 expression via western blotting and flow cytometric analyses. Radioactive uptake of 18 F-FDG by established stable NSCLC cell lines (HCC827, H1975) with different levels of CD147 expression and the corresponding xenografts was assessed through γ-radioimmunoassays in vitro and micro-PET/CT imaging in vivo to study the role of CD147 in glucose metabolic reprogramming...
October 15, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/30319615/epidemiology-and-immune-pathogenesis-of-viral-sepsis
#9
REVIEW
Gu-Lung Lin, Joseph P McGinley, Simon B Drysdale, Andrew J Pollard
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis can be caused by a broad range of pathogens; however, bacterial infections represent the majority of sepsis cases. Up to 42% of sepsis presentations are culture negative, suggesting a non-bacterial cause. Despite this, diagnosis of viral sepsis remains very rare. Almost any virus can cause sepsis in vulnerable patients (e.g., neonates, infants, and other immunosuppressed groups). The prevalence of viral sepsis is not known, nor is there enough information to make an accurate estimate...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30315136/clinicopathological-features-and-outcome-of-antibody-negative-anti-glomerular-basement-membrane-disease
#10
Dandan Liang, Shaoshan Liang, Feng Xu, Mingchao Zhang, Xiaomei Li, Yiyao Tu, Zhihong Liu, Caihong Zeng
AIM: To explore the clinicopathological characteristics of patients with anti-GBM antibody-negative anti-GBM disease. METHODS: The clinical and renal pathological findings were retrospectively studied in 19 patients. All patients met the following inclusion criteria: linear GBM IgG deposition on immunofluorescence(IF); and lack of serum anti-GBM antibodies by ELISA and indirect immunofluorescence assay. RESULTS: There were 17 male and two female patients, with a median age of 36 years (range 15-61 years)...
October 12, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/30308300/targeted-codelivery-of-doxorubicin-and-il-36%C3%AE-expression-plasmid-for-an-optimal-chemo-gene-combination-therapy-against-cancer-lung-metastasis
#11
Yichao Chen, Jingjing Sun, Yixian Huang, Yanhua Liu, Lei Liang, Da Yang, Binfeng Lu, Song Li
Cancer metastasis is the main cause for the high mortality in breast cancer patients. In this work we developed a polymer POEG-st-Pmor for targeted co-delivery of IL-36γ expression plasmid and doxorubicin (Dox) to lung metastasis of breast cancer. The polymer readily formed micelles that were effective in loading Dox and simultaneously forming complexes with IL-36γ plasmid. Interestingly, particles co-loaded with Dox and plasmid was significantly smaller and more stable than the particles loaded with Dox only...
October 8, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/30303525/bos-is-associated-with-decreased-hdac2-from-steroid-resistant-lymphocytes-in-the-small-airways
#12
Greg Hodge, Sandra Hodge, Aeneas Yeo, Phan Nguyen, Emily Hopkins, Hong Liu, C L Holmes-Liew, Mark Holmes
Immunosuppression therapies including corticosteroids fail to prevent bronchiolitis obliterans syndrome (BOS), primarily a disease of the small airways, following lung transplantation. We reported increases in steroid-resistant pro-inflammatory lymphocytes and their loss of histone deacetylase 2 (HDAC2), an important mediator of steroid action, in the blood of stable lung transplant recipients. We noted similar increases in the steroid-resistant lymphocytes in both the blood and small airways in BOS compared with the large airways...
October 10, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/30295423/relationship-between-esophageal-abnormalities-on-fluoroscopic-esophagram-and-pulmonary-function-testing-in-juvenile-systemic-sclerosis
#13
Lusine Ambartsumyan, Hengqi B Zheng, Ramesh S Iyer, Jennifer Soares, Gretchen Henstorf, Anne M Stevens
OBJECTIVE: Juvenile systemic sclerosis (jSSc) is a disabling autoimmune condition that affects multiple organs in addition to skin, notably the gastrointestinal and pulmonary systems. The relationship between esophageal abnormalities and pulmonary disease in jSSc is not well understood. We describe associations between radiologic esophageal abnormalities and pulmonary function. METHODS: Clinical and radiographic data of children less than 18 years who fulfilled 2007 Pediatric Rheumatology Provisional Classification Criteria for jSSc between 1994 and 2016 were reviewed...
October 8, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/30294332/anti-glucocorticoid-induced-tumor-necrosis-factor-related-protein-gitr-therapy-overcomes-radiation-induced-treg-immunosuppression-and-drives-abscopal-effects
#14
Jonathan E Schoenhals, Taylor R Cushman, Hampartsoum B Barsoumian, Ailin Li, Alexandra P Cadena, Sharareh Niknam, Ahmed I Younes, Mauricio da Silva Caetano, Maria Angelica Cortez, James W Welsh
Despite the potential to cure metastatic disease, immunotherapy on its own often fails outright or early on due to tumor immune evasion. To address this obstacle, we investigated combinations of anti-GITR, anti-PD1 and radiation therapy (XRT) in our previously developed anti-PD1 resistant 344SQ non-small cell lung adenocarcinoma preclinical tumor model. We hypothesized that targeting multiple mechanisms of immune evasion with this triple therapy would lead to an enhanced tumor-specific immune response and improve survival more so than any mono- or dual therapy...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30290827/focal-ischemic-stroke-leads-to-lung-injury-and-reduces-alveolar-macrophage-phagocytic-capability-in-rats
#15
Cynthia S Samary, Alane B Ramos, Lígia A Maia, Nazareth N Rocha, Cíntia L Santos, Raquel F Magalhães, Amanda L Clevelario, Pedro M Pimentel-Coelho, Rosália Mendez-Otero, Fernanda F Cruz, Vera L Capelozzi, Tatiana P T Ferreira, Thea Koch, Marcelo Gama de Abreu, Claudia C Dos Santos, Paolo Pelosi, Pedro L Silva, Patricia R M Rocco
BACKGROUND: Ischemic stroke causes brain inflammation, which we postulate may result in lung damage. Several studies have focused on stroke-induced immunosuppression and lung infection; however, the possibility that strokes may trigger lung inflammation has been overlooked. We hypothesized that even focal ischemic stroke might induce acute systemic and pulmonary inflammation, thus altering respiratory parameters, lung tissue integrity, and alveolar macrophage behavior. METHODS: Forty-eight Wistar rats were randomly assigned to ischemic stroke (Stroke) or sham surgery (Sham)...
October 5, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30290600/manifestations-and-outcomes-of-nocardia-infections-comparison-of-immunocompromised-and-nonimmunocompromised-adult-patients
#16
COMPARATIVE STUDY
Julie Steinbrink, Joan Leavens, Carol A Kauffman, Marisa H Miceli
Nocardia is a ubiquitous environmental pathogen that causes infection primarily following inhalation into the lungs. It is generally thought to cause infection primarily in immunocompromised patients, but nonimmunocompromised individuals are also at risk of infection. We sought to compare risk factors, clinical manifestations, diagnostic approach, treatment, and mortality in immunocompromised and nonimmunocompromised adults with nocardiosis.We studied all adults with culture-proven Nocardia infection at a tertiary care hospital from 1994 to 2015 and compared immunocompromised with nonimmunocompromised patients...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30288347/combination-with-sgt-53-overcomes-tumor-resistance-to-a-checkpoint-inhibitor
#17
Sang-Soo Kim, Joe B Harford, Manish Moghe, Antonina Rait, Esther H Chang
The tumor suppressor p53 responds to genotoxic and oncogenic stresses by inducing cell cycle arrest and apoptosis. Recent studies suggest that p53 also participates in the regulation of cellular immune responses. Here, we have investigated the potential of p53 gene therapy to augment immune checkpoint inhibition by combining an anti-programmed cell death protein 1 (PD1) antibody with SGT-53, our investigational nanomedicine carrying a plasmid encoding human wild-type p53. In three syngeneic mouse tumor models examined including a breast cancer, a non-small cell lung carcinoma, and a glioblastoma, SGT-53 sensitized otherwise refractory tumors to anti-PD1 antibody...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/30285929/-dermatomyositis-associated-with-anti-mda5-autoantibody
#18
María Victoria Collado, María De Los Ángeles Gargiulo, Ramiro Gómez, Graciela Gómez, Nicolás Pérez, Lorena Suarez, Ana Lía Taratuto, Patricia Aruj
Dematomyositis is an idiopathic inflammatory myopathy with a variable clinical spectrum. In recent years, a number of myositis-specific antibodies have been identified including anti-MDA5, which is us eful for diagnosis, prognosis and classification of the diverse clinical forms of the disease. This antibody is associated with cutaneous ulcers, rapidly progressive interstitial lung disease, early mortality and poor prognosis, so the detection of this antibody in a suitable clinical context, raises the need for an aggressive immunosuppressive treatment...
2018: Medicina
https://www.readbyqxmd.com/read/30284414/-integral-approach-to-the-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#19
J González Del Castillo, F J Candel, J de la Fuente, F Gordo, F J Martín-Sánchez, R Menéndez, A Mujal, J Barberán
Chronic obstructive pulmonary disease is a set of clinical processes that have in common a chronic and progressive obstruction to airflow, with episodes of exacerbation. These exacerbations are more frequent and severe over time, deteriorating the lung function. The main cause of exacerbations is bacterial infection. There are multiple guidelines and documents that statement the management of this pathology. However, they focus primarily on the treatment during the stable phase. This document addresses the problem of acute exacerbation due to an infection from a multidisciplinary perspective, focusing on the integral approach to the process, and including etiology, microbiological studies, resistance to antimicrobials, risk stratification and initial empirical therapeutic management (antibiotic and concomitant)...
October 4, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/30279512/a-dendritic-cell-based-systemic-vaccine-induces-long-lived-lung-resident-memory-th17-cells-and-ameliorates-pulmonary-mycosis
#20
Keigo Ueno, Makoto Urai, Sota Sadamoto, Minoru Shinozaki, Shogo Takatsuka, Masahiro Abe, Yoshiko Otani, Nao Yanagihara, Kiminori Shimizu, Yoichiro Iwakura, Kazutoshi Shibuya, Yoshitsugu Miyazaki, Yuki Kinjo
Tissue-resident memory T cells (TRMs) are a novel nonvascular memory T cell subset. Although CD8+ TRMs are well-characterized, CD4+ TRMs-especially lung-resident memory Th17 cells-are still being defined. In this study, we characterized lung-resident memory Th17 cells (lung TRM17) and their role in protection against the highly virulent fungus Cryptococcus gattii. We found that intravenously transferred DCs preferentially migrated to lungs and attracted recipient DCs and led to the induction of long-lived Th17 cells expressing characteristic markers...
October 2, 2018: Mucosal Immunology
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