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Emily Young, Brian Westerberg, Anat Yanai, Kevin Gregory-Evans
The olfactory mucosa contains cells that enable it to generate new neurons and other supporting cells throughout life, allowing it to replace cells of the mucosa that have been damaged by exposure to various insults. In this article, we discuss the different types of stem cell found within the olfactory mucosa and their properties. In particular, the mesenchymal-like cells found within the lamina propria will be reviewed in detail. In addition, we discuss potential applications of olfactory-derived stem cells toward hearing regeneration secondary to either inner hair cell loss or primary or secondary auditory nerve degeneration...
August 16, 2018: Regenerative Medicine
Nitzan Kutnowski, Hagay Shmuely, Idit Dahan, Fania Shmulevich, Geula Davidov, Anat Shahar, Jerry Eichler, Raz Zarivach, Boaz Shaanan
Protein-DNA interactions are highly dependent on salt concentration. To gain insight into how such interactions are maintained in the highly saline cytoplasm of halophilic archaea, we determined the 3-D structure of VNG0258H/RosR, the first haloarchaeal DNA-binding protein from the extreme halophilic archaeon Halobactrium salinarum. It is a dimeric winged-helix-turn-helix (wHTH) protein with unique features due to adaptation to the halophilic environment. As ions are major players in DNA binding processes, particularly in the halophilic environments, we investigated the solution structure of the ionic envelope and located anions in the first shell around the protein in the crystal using anomalous scattering...
August 12, 2018: Journal of Structural Biology
Julia C Young, Michelle R Quayle, Justin W Adams, John F Bertram, Paul G McMenamin
The practical aspect of human developmental biology education is often limited to the observation and use of animal models to illustrate developmental anatomy. This is due in part to the difficulty of accessing human embryonic and fetal specimens, and the sensitivity inherent to presenting these specimens as teaching materials. This report presents a new approach using three-dimensional (3D) printed replicas of actual human materials in practical classes, thus allowing for the inclusion of accurate examples of human developmental anatomy in the educational context...
August 14, 2018: Anatomical Sciences Education
Zohar Lahav-Kadmiel, Anat Brunstein-Klomek
INTRODUCTION: The association between bullying victimization and depressive symptoms has been studied extensively over the years. Among the variables studied as having an impact on this association were different characteristics of the parent-child relationship. The current study was the first to specifically examine parent-child conflicts as a moderator in the association between victimization and depressive symptoms among adolescents. In addition, it was the first to examine the roles of the child and parent's gender in this moderation...
August 7, 2018: Journal of Adolescence
Joshua Pottel, Anat Levit, Magdalena Korczynska, Marcus Fischer, Brian K Shoichet
Unrelated ligands, often found in drug discovery campaigns, can bind to the same receptor, even with the same protein residues. To investigate how this might occur, and whether it might be typically possible to find unrelated ligands for the same drug target, we sought examples of topologically unrelated ligands that bound to the same protein in the same site. Seventy-six pairs of ligands, each bound to the same protein (152 complexes total), were considered, classified into three groups. In the first (31 pairs of complexes), unrelated ligands interacted largely with the same pocket residues through different functional groups...
August 10, 2018: ACS Chemical Biology
Robert Gailey, Anat Kristal, Jennifer Lucarevic, Shane Harris, Brooks Applegate, Ignacio Gaunaurd
BACKGROUND: Prosthetic socket fit is an important element associated with successful ambulation and use of a prosthesis. Prosthetists and rehabilitation clinicians would benefit from an assessment tool that discriminates between and quantifies the multiple determinants that influence the lower limb amputee's performance and satisfaction of a prosthetic socket. OBJECTIVES: To determine the internal consistency of the comprehensive lower limb amputee socket survey, a new self-report measure of prosthetic socket satisfaction that quantifies suspension, stability, comfort, and appearance...
August 10, 2018: Prosthetics and Orthotics International
Liancai Mu, Jingming Chen, Jing Li, Matthew Arnold, Stanislaw Sobotka, Themba Nyirenda, Mary Fowkes, Mark Christopherson, Ira Sanders
The human soft palate plays an important role in respiration, swallowing, and speech. These motor activities depend on reflexes mediated by sensory nerve endings. To date, the details of human sensory innervation to the soft palate have not been demonstrated. In this study, eight adult human whole-mount (soft palate-tongue-pharynx-larynx-upper esophagus) specimens were obtained from autopsy. Each specimen was bisected in the midline, forming two equal and symmetrical halves. Eight hemi-specimens were processed with Sihler's stain, a whole-mount nerve staining technique...
August 6, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Anat Tzur Mahalel
This paper offers a reading of psychoanalyst Abram Kardiner's memoir, which tells the story of his analytic encounter with Freud in the early 1920s. The memoir describes Kardiner's dependence on caretakers, parents, and psychoanalysts, as well as painful separations that are understood in relation to his deprived childhood. These memories were revived in analysis and then reactivated in its abrupt termination. In retrospect, it can be seen that Kardiner's work of memory and mourning is tied in ambiguous ways to Freud's mourning over his daughter Sophie at the time...
August 2018: Psychoanalytic Review
Reem Younis, Eran Berkowitz, Roni Shreter, Anat Kesler, Itzhak Braverman
Purpose: To report a case of right eye blindness due to a penetrating injury in the contralateral nostril. Methods: This is a case report of a 67-year-old patient who presented to the emergency room complaining of transient blurred vision in his right eye after falling on a small branch with no apparent injury besides minor lacerations. The following day, the patient experienced blindness in the right eye. Physical examination revealed small lacerations on his left forehead and optic neuropathy on the right side with no other obvious discerning physical or imaging abnormalities...
May 2018: Case Reports in Ophthalmology
Tatyana Pozner, Yulia Vistoropsky, Stan Moaraf, Rachel Heiblum, Anat Barnea
To date, studies that reported seasonal patterns of adult neurogenesis and neuronal recruitment have correlated them to seasonal behaviors as the cause or as a consequence of neuronal changes. The aim of our study was to test this correlation, and to investigate whether there is a seasonal pattern of new neuronal recruitment that is not correlated to behavior. To do this, we used adult female zebra finches (songbirds that are not seasonal breeders), kept them under constant social, behavioral, and spatial environments, and compared neuronal recruitment in their brains during two seasons, under natural and laboratory conditions...
July 26, 2018: Scientific Reports
Matthew K Adams, Salomon-Yves Cohen, Eric H Souied, Dafna Goldenberg, Anat Loewenstein, Timothy W Olsen, Jose S Pulido
PURPOSE: To describe modern multimodal imaging of the choroidal and optic disk vessels in optic disk pits. METHODS: Case reports of four patients with optic disk pit who underwent multimodal imaging of the optic pit and surrounding structures. Patients included in this article were found to have optic disk pits and subsequently underwent multimodal imaging. RESULTS: Cilioretinal arteries were present in two of the four cases (50%). SPECTRALIS optical coherence tomography showed intraretinal and subretinal fluid in all cases...
July 24, 2018: Retinal Cases & Brief Reports
Matias Iglicki, Catharina Busch, Anat Loewenstein, Adrian T Fung, Alessandro Invernizzi, Miriana Mariussi, Romina Arias, Pierre-Henry Gabrielle, Zafer Cebeci, Mali Okada, Jerzy Nawrocki, Zofia Michalewska, Michaella Goldstein, Adiel Barak, Dinah Zur
PURPOSE: To report a cohort with optic disk pit maculopathy (ODPM) presenting with neurosensory macular detachment that were initially misdiagnosed and mistreated; and to describe structural features on spectral domain optical coherence tomography in misdiagnosed and all other consecutive cases of ODPM. METHODS: Multicenter international retrospective cohort study. PARTICIPANTS: 59 eyes from 59 patients with ODPM. MAIN OUTCOME MEASURES: 1) Proportion of patients with ODPM initially misdiagnosed, inaccurate diagnosis and treatment...
July 24, 2018: Retina
Jenan Awesat, Iftach Sagy, Yosef S Haviv, Anat Rabinovich, Alan Jotkowitz, Elena Shleyfer, Leonid Barski
BACKGROUND: Anticoagulant induced renal injury has been previously described with Warfarin treatment. In the last decade direct oral anticoagulants (DOAC) were introduced. They include direct inhibitors of factor Xa (Rivaroxaban, Apixaban, Edoxaban) and a thrombin inhibitor (Dabigatran). There are isolated reports describing acute kidney injury (AKI) due to the use of DOACs. CASE REPORT: We report a clinical case of an 80-year-old patient recently started on Dabigatran for new onset atrial fibrillation...
July 19, 2018: Thrombosis Research
Avi Leader, Noam Benyamini, Anat Gafter-Gvili, Juliet Dreyer, Bronya Calvarysky, Alina Amitai, Osnat Yarchovsky-Dolberg, Giora Sharf, Eric Tousset, Opher Caspi, Martin Ellis, Itai Levi, Sabina De Geest, Pia Raanani
BACKGROUND: Nonadherence to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) has been associated with inferior outcomes. Scarce evidence exists on the effectiveness of adherence-enhancing interventions. The present pilot study evaluated the feasibility and effectiveness of an intervention to improve TKI adherence in adult CML patients. PATIENTS AND METHODS: Using a quasi-experimental pre-post intervention design, we included a convenience sample of 58 CML patients (median age, 60...
June 25, 2018: Clinical Lymphoma, Myeloma & Leukemia
Rachel Blau, Yana Epshtein, Evgeni Pisarevsky, Galia Tiram, Sahar Israeli Dangoor, Eilam Yeini, Adva Krivitsky, Anat Eldar-Boock, Dikla Ben-Shushan, Hadas Gibori, Anna Scomparin, Ori Green, Yael Ben-Nun, Emmanuelle Merquiol, Hila Doron, Galia Blum, Neta Erez, Rachel Grossman, Zvi Ram, Doron Shabat, Ronit Satchi-Fainaro
Complete tumor removal during surgery has a great impact on patient survival. To that end, the surgeon should detect the tumor, remove it and validate that there are no residual cancer cells left behind. Residual cells at the incision margin of the tissue removed during surgery are associated with tumor recurrence and poor prognosis for the patient. In order to remove the tumor tissue completely with minimal collateral damage to healthy tissue, there is a need for diagnostic tools that will differentiate between the tumor and its normal surroundings...
2018: Theranostics
Oshri Wasserzug, Gad Fishman, Anat Wengier, Yael Oestreicher-Kedem, Ophir Handzel, Dan M Fliss, Nevo Margalit, Ahmad Safadi, Ari DeRowe
BACKGROUND: Direct laryngoscopy and rigid bronchoscopy are currently performed using 2-dimensional endoscopic systems. Our objective was to determine whether a 3-dimensional endoscopic system can enhance visualization of the surgical field in pediatric direct laryngoscopy and rigid bronchoscopy. METHODS: A prospective cohort study was conducted. Thirty three children who underwent direct laryngoscopies in a tertiary referral children's hospital were enrolled. Direct laryngoscopy was performed using both 2- and 3-dimensional endoscopic systems, after which the surgeons scored the quality of the images obtained with each system on a scale from 1 (low) to 5 (high)...
July 6, 2018: American Journal of Otolaryngology
Sheila K Marshall, Tim Stainton, Jessie M Wall, Ma Zhu, John Murray, Siwei Wu, Asmae El Bouhali, Filomena Parada, Anat Zaidman-Zait, Richard A Young
Eight dyads ( N = 16) residing in Western Canada participated in this investigation of how young adults with intellectual and developmental disabilities (IDD) and their parents jointly construct, articulate, and act on goals pertinent to the young adults' transition to adulthood. Using the action-project method to collect and analyze conversations and video recall data, cases were grouped representing the ways goal-directed projects brought relationship ( n = 4), planning ( n = 3) or both ( n = 1) to the foreground as joint projects...
August 2018: Intellectual and Developmental Disabilities
Anat Brunstein Klomek, Shira Barzilay, Alan Apter, Vladimir Carli, Christina W Hoven, Marco Sarchiapone, Gergö Hadlaczky, Judit Balazs, Agnes Kereszteny, Romuald Brunner, Michael Kaess, Julio Bobes, Pilar A Saiz, Doina Cosman, Christian Haring, Raphaela Banzer, Elaine McMahon, Helen Keeley, Jean-Pierre Kahn, Vita Postuvan, Tina Podlogar, Merike Sisask, Airi Varnik, Danuta Wasserman
BACKGROUND: The association between bullying victimization and depression, suicide ideation and suicide attempts has been studied mainly in cross-sectional studies. This study aims to test the bidirectional effect and the chronicity versus sporadic effect of physical, verbal, and relational bullying victimization on suicidal ideation/attempts and depression. METHODS: Longitudinal assessments with an interval of 3- and 12-months were performed within a sample of 2,933 adolescents (56...
July 19, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Chris Wiebe, Anat Tambur, Peter W Nickerson
At a 2016 FDA public meeting on patient-focused drug development, transplant recipients highlighted the need to individualize and simplify immunosuppressive therapy. Unfortunately, evidence indicates center practice drives US transplant program variation in choice of immunosuppression rather than individualized alloimmune risk assessment. Moreover, while a number of patient or donor attributes are prognostic of post-transplant immunologic risk at a population level, their utility to individualize therapy is unproven...
July 19, 2018: American Journal of Transplantation
Anna Gorelick-Ashkenazi, Ron Weiss, Lena Sapozhnikov, Anat Florentin, Lama Tarayrah-Ibraheim, Dima Dweik, Keren Yacobi-Sharon, Eli Arama
Maintenance of tissue integrity during development and homeostasis requires the precise coordination of several cell-based processes, including cell death. In animals, the majority of such cell death occurs by apoptosis, a process mediated by caspase proteases. To elucidate the role of caspases in tissue integrity, we investigated the behavior of Drosophila epithelial cells that are severely compromised for caspase activity. We show that these cells acquire migratory and invasive capacities, either within 1-2 days following irradiation or spontaneously during development...
July 18, 2018: Nature Communications
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