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https://www.readbyqxmd.com/read/30537111/chromatin-dynamics-governed-by-a-set-of-nuclear-structural-proteins
#1
Anat Vivante, Eugene Brozgol, Irena Bronshtein, Vered Levi, Yuval Garini
During the past three decades, the study of nuclear and chromatin organization has become of great interest. The organization and dynamics of chromatin are directly responsible for many functions including gene regulation, genome replication, and maintenance. In order to better understand the details of these mechanisms, we need to understand the role of specific proteins that take part in these processes. The genome in the nucleus is organized in different length scales, ranging from the bead-like nucleosomes through topological associated domains (TADs) up to chromosome territories...
December 9, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/30537042/myofibril-assembly-in-cultured-mouse-neonatal-cardiomyocytes
#2
Jennifer White, Jushuo Wang, Yingli Fan, Dipak K Dube, Joseph W Sanger, Jean M Sanger
The formation of myofibrils was analyzed in neonatal mouse cardiomyocytes grown in culture and stained with fluorescent antibodies directed against myofibrillar proteins. The cardiomyocyte cultures also were exposed to siRNA probes to test the role of nonmuscle myosin IIB expression in the formation of myofibrils. In culture, new myofibrils formed in the spreading cell margins surrounding contractile myofibrils previously assembled in utero. Observations indicated that assembly of mature myofibrils occurred in three-stages, as previously reported in cultured mouse skeletal muscle...
December 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/30535100/seven-versus-fourteen-days-of-antibiotic-therapy-for-uncomplicated-gram-negative-bacteremia-a-non-inferiority-randomized-controlled-trial
#3
Dafna Yahav, Erica Franceschini, Fidi Koppel, Adi Turjeman, Tanya Babich, Roni Bitterman, Ami Neuberger, Nesrin Ghanem-Zoubi, Antonella Santoro, Noa Eliakim-Raz, Barak Pertzov, Tali Steinmetz, Anat Stern, Yaakov Dickstein, Elias Maroun, Hiba Zayyad, Jihad Bishara, Danny Alon, Yonatan Edel, Elad Goldberg, Claudia Venturelli, Cristina Mussini, Leonard Leibovici, Mical Paul
Background: Gram-negative bacteremia is a major cause of morbidity and mortality in hospitalized patients. Data to guide the duration of antibiotic therapy are limited. Methods: Randomized, multicenter, open-label, non-inferiority trial. Inpatients with Gram-negative bacteremia, afebrile and hemodynamically stable for at least 48 hours, were randomized to receive 7 (intervention) or 14 days (control) of covering antibiotic therapy. Patients with uncontrolled focus of infection were excluded...
December 11, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30531646/vestibular-traumatic-neuroma-following-temporal-bone-fracture
#4
Renata M Knoll, Danielle R Trakimas, Reuven Ishai, Anat Stemmer-Rachamimov, Aaron K Remenschneider, Joseph B Nadol, David H Jung, Elliott D Kozin
No abstract text is available yet for this article.
January 2019: Otology & Neurotology
https://www.readbyqxmd.com/read/30523589/the-microvascular-pericyte-approaches-to-isolation-characterization-and-cultivation
#5
Paula Dore-Duffy, Nilufer Esen
The microvascular pericyte was identified in 1873 by the French scientist Charles Benjamin Rouget and originally called the Rouget cell (Rouget.Sciences 88:916-8, 1879). However, it was not until the early 1900s that Rouget's work was confirmed, and the Rouget cell renamed the pericyte by virtue of its peri-endothelial location (Dore. Brit J Dermatol 35:398-404, 1923; Zimmermann. Z Anat Entwicklungsgesch 68:3-109, 1923). Over the years a large number of publications have emerged, but the pericyte has remained a truly enigmatic cell...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30523248/engrafted-parenchymal-brain-macrophages-differ-from-microglia-in-transcriptome-chromatin-landscape-and-response-to-challenge
#6
Anat Shemer, Jonathan Grozovski, Tuan Leng Tay, Jenhan Tao, Alon Volaski, Patrick Süß, Alberto Ardura-Fabregat, Mor Gross-Vered, Jung-Seok Kim, Eyal David, Louise Chappell-Maor, Lars Thielecke, Christopher K Glass, Kerstin Cornils, Marco Prinz, Steffen Jung
Microglia are yolk sac-derived macrophages residing in the parenchyma of brain and spinal cord, where they interact with neurons and other glial. After different conditioning paradigms and bone marrow (BM) or hematopoietic stem cell (HSC) transplantation, graft-derived cells seed the brain and persistently contribute to the parenchymal brain macrophage compartment. Here we establish that graft-derived macrophages acquire, over time, microglia characteristics, including ramified morphology, longevity, radio-resistance and clonal expansion...
December 6, 2018: Nature Communications
https://www.readbyqxmd.com/read/30513276/educational-lectures-enhance-knowledge-about-the-human-immunodeficiency-virus-hiv-and-reduce-risky-behavior-and-fear-among-methadone-maintenance-treatment-patients
#7
Idan Barak, Miriam Adelson, Anat Sason, Yuval Livnat, Shaul Schreiber, Einat Peles
BACKGROUND: The aim of this study was to characterize human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)-related knowledge and stigma among methadone maintenance treatment (MMT) patients and evaluate the contribution of an educational lecture in reducing risky behavior and unjustified overprotective behavior due to fear and stigma among MMT patients. METHODS: Patients from an MMT clinic within a tertiary medical center were invited to an educational lecture on HIV/AIDS...
December 4, 2018: Substance Abuse
https://www.readbyqxmd.com/read/30512206/derivatization-free-method-for-compound-specific-isotope-analysis-of-nonexchangeable-hydrogen-of-4-bromophenol
#8
Tomasz Kuder, Anat Bernstein, Faina Gelman
RATIONALE: Compound-specific isotope analysis (CSIA) is a valuable tool in environmental chemistry and in other fields of science. Currently, hydrogen CSIA of polar compounds containing exchangeable hydrogen is uncommon. To extend the scope of CSIA applications, we present an alternative method of analysis, bypassing the typical step of derivatization. The method is demonstrated for two environmental contaminants, 4-bromophenol (4BP) and 2,4,6-tribromophenol (TBP) METHODS: Net isotope ratios obtained by CSIA combine the isotope composition of nonexchangeable, carbon-bound hydrogen and the exchangeable hydroxyl hydrogen...
December 4, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/30503929/adaptation-of-health-systems-to-climate-related-migration-in-sub-saharan-africa-closing-the-gap
#9
Maya Negev, Na'ama Teschner, Anat Rosenthal, Hagai Levine, Clara Lew-Levy, Nadav Davidovitch
Health systems worldwide need to be adapted to cope with growing numbers of migrants and to climate-exacerbated morbidity. Heatwaves, water stress, desertification, flooding, and sea level rise are environmental stressors that increase morbidity, mortality, and poor mental health in Sub-Saharan Africa. While most migration is intra-African, climate change is also affecting migration patterns outside the continent. To tackle the health challenges induced by these events, such as infectious diseases and malnutrition, health care providers in Sub-Saharan Africa and in receiving countries in Europe must adapt their systems to provide appropriate health services to these communities...
November 28, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/30503230/control-mechanisms-of-static-and-dynamic-balance-in-adults-with-and-without-vestibular-dysfunction-in-oculus-virtual-environments
#10
REVIEW
Anat V Lubetzky, Bryan D Hujsak, Jennifer L Kelly, Gene Fu, Ken Perlin
BACKGROUND: Deficits in sensory integration and fear of falling in complex environments contribute to decreased participation of adults with vestibular disorders. With recent advances in virtual reality technology, head-mounted displays are affordable and allow manipulation of the environment to test postural responses to visual changes. OBJECTIVES: To develop an assessment of static and dynamic balance with the Oculus Rift and (1) to assess test-retest reliability of each scene in adults with and without vestibular hypofunction; (2) to describe changes in directional path and sample entropy in response to changes in visuals and surface and compare between groups; and (3) to evaluate the relation between balance performance and self-reported disability and balance confidence...
November 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/30502048/relation-of-neutrophil-to-lymphocyte-ratio-to-risk-of-incident-atrial-fibrillation
#11
Anat Berkovitch, Arwa Younis, Yoni Grossman, Shlomo Segev, Shaye Kivity, Yechezkel Sidi, Roy Beinart, Ilan Goldenberg, Elad Maor
Clinical and experimental data support a critical role for inflammation in cardiovascular disease. The purpose of the current study was to examine the relation between an inflammatory marker, neutrophil-to-lymphocyte ratio (NLR), and incident atrial fibrillation (AF) in asymptomatic adults. We investigated 21,118 self-referred men and women who were annually screened in a tertiary medical center. All subjects were free of AF at baseline and had their serum NLR calculated at the first annual visit. Subjects were divided into 2 groups based on their baseline NLR: Low (<2...
November 7, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30498330/biosimilars-in-ophthalmology-is-there-a-big-change-on-the-horizon
#12
REVIEW
Ashish Sharma, Prahalad Reddy, Baruch D Kuppermann, Francesco Bandello, Anat Lowenstein
Retinal disease management has witnessed remarkable advances in posterior segment pharmacotherapy with the development of anti-VEGF molecules such as Lucentis® (ranibizumab), Eylea® (aflibercept), and off-label bevacizumab (Avastin). The US patents for ranibizumab and aflibercept will expire in 2020 (though Regeneron has indicated that it might attempt to extend its US patent to June 2023 with additional patent claims), and their European patents will expire in 2022 and 2025. Aflibercept comes off patent in 2022 in People's Republic of China and Japan...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/30489692/the-effect-of-periprocedural-beta-blocker-withdrawal-on-arrhythmic-risk-following-transcatheter-aortic-valve-replacement
#13
Arwa Younis, Katia Orvin, Eyal Nof, Israel M Barabash, Amit Segev, Anat Berkovitch, Victor Guetta, Abid Assali, Ran Kornowski, Roy Beinart
OBJECTIVE: To evaluate the efficacy and safety of periprocedural beta-blocker (BB) discontinuation among patients undergoing transcatheter aortic valve replacement (TAVR) and high degree atrioventricular block (HD-AVB) and/or atrial fibrillation (AF). METHODS: The study population comprised 743 consecutive patients who underwent TAVR between 2009 and 2017 in two high-volume tertiary centers. All patients received chronic BB therapy, and were divided into two groups: (1) BB continuation and (2) BB discontinued 24 hr prior to the procedure...
November 29, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30482309/gait
#14
Anat Mirelman, Shirley Shema, Inbal Maidan, Jeffery M Hausdorff
Gait is one of the keys to functional independence. For a long-time, walking was considered an automatic process involving minimal higher-level cognitive input. Indeed, walking does not take place without muscles that move the limbs and the "lower-level" control that regulates the timely activation of the muscles. However, a growing body of literature suggests that walking can be viewed as a cognitive process that requires "higher-level" cognitive control, especially during challenging walking conditions that require executive function and attention...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/30479873/intravitreal-trimethoprim-and-sulfamethoxazole-toxicity-to-the-retina-of-albino-rabbits
#15
Orit Mazza, Zohar Habot-Wilner, Jonathan Shahar, Irit Mann, Anat Loewenstein, Ido Perlman
Purpose: To evaluate retinal toxicity of intravitreal trimethoprim-sulfamethoxazole (TMP-SMX) in an albino rabbit model. Methods: Albino rabbits ( N = 10) were treated in the right eye with the maximum intravitreal dose of TMP-SMX mixture (1600 μg/8000 μg /0.1 mL), while 0.1 mL saline was injected into the vitreous of the left eye. Clinical examination and electrophysiological (electroretinogram [ERG] and visual evoked potentials [VEPs]) testing were conducted before injection, 3 days, 1, 2, and 4 weeks postinjection...
November 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/30476619/individual-variability-in-female-and-male-mice-in-a-test-retest-protocol-of-the-forced-swim-test
#16
Lydmila Kazavchinsky, Anat Dafna, Haim Einat
BACKGROUND: The challenges to embody the complexity of symptoms and biological mechanism of affective disorders question the value of animal models as well as their reproducibility and validity. Validity is further hindered by large individual variability in many models. Whereas individual variability presents a challenge, it can also be used to study susceptibility and resistance. One of the frequently used models for screening antidepressants and interventions related to depression is the forced swim test (FST)...
November 23, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/30471299/a-primer-set-for-comprehensive-amplification-of-v-genes-from-rhesus-macaque-origin-based-on-repertoire-sequencing
#17
Ronit Rosenfeld, Anat Zvi, Eitan Winter, Ronen Hope, Ofir Israeli, Ohad Mazor, Gur Yaari
Recombinant antibodies serve as therapeutic molecules for a broad range of applications. High affinity antibodies are typically isolated following an active and effective immunization. Human-like antibodies may be obtained from immunized nonhuman primates (NHP), such as rhesus macaque, when immunized human origin is not available. For the isolation of such antibodies, strategies like phage and yeast display, are employed. These strategies are primarily based on the amplification of the rearranged variable (V) regions coded by mRNA, obtained from lymphatic source of immunized animals...
November 22, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/30471241/comparison-of-topical-5-fluorouracil-and-interferon-alfa-2b-as-primary-treatment-modalities-for-ocular-surface-squamous-neoplasia
#18
Nandini Venkateswaran, Carolina Mercado, Anat Galor, Carol L Karp
PURPOSE: To compare the efficacy of topical 5-fluorouracil 1% (5FU) and interferon alfa-2b 1 MIU/mL (IFN) eye drops as primary treatment modalities for ocular surface squamous neoplasia (OSSN). DESIGN: Retrospective, comparative, interventional case series. METHODS: Fifty-four patients who received 5FU and 48 patients who received IFN as primary therapy for OSSN were included. Primary outcome measures were the frequency of clinical resolution and time to OSSN recurrence by treatment modality...
November 21, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/30465209/quantitative-identification-of-senescent-cells-in-cancer
#19
Anat Biran, Ziv Porat, Valery Krizhanovsky
Cellular senescence, a state of permanent growth arrest, is an important mechanism preventing the propagation of damaged cells. It suppresses cancer development in premalignant lesions in response to activated oncogenes and in tumors following therapy. The presence of senescent cells in premalignant lesions and tumors is controlled by the immune system. The ability to identify and quantify senescent cells more efficiently in vivo is necessary in order to evaluate the effect of these cells on tumorigenesis and cancer therapy...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30461225/trabecular-bone-fraction-variation-in-modern-humans-fossil-hominins-and-other-primates
#20
Habiba Chirchir
Evidence suggests that recent modern humans (Holocene) have low trabecular bone density (i.e., trabecular bone fraction, TBF) compared with other extant primates and fossil hominins. However, the extent to which TBF in recent humans with varying subsistence strategies differs from that of fossil hominins, and in turn, how hominins differ from various extant catarrhines is unclear. This study tests the hypotheses that first, populations with subsistence strategies demanding high physical activity exhibit greater TBF than sedentary populations and are more similar to fossil Homo...
November 21, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
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