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https://www.readbyqxmd.com/read/30464537/non-eosinophilic-asthma-current-perspectives
#1
REVIEW
Ignacio Esteban-Gorgojo, Darío Antolín-Amérigo, Javier Domínguez-Ortega, Santiago Quirce
Although non-eosinophilic asthma (NEA) is not the best known and most prevalent asthma phenotype, its importance cannot be underestimated. NEA is characterized by airway inflammation with the absence of eosinophils, subsequent to activation of non-predominant type 2 immunologic pathways. This phenotype, which possibly includes several not well-defined subphenotypes, is defined by an eosinophil count <2% in sputum. NEA has been associated with environmental and/or host factors, such as smoking cigarettes, pollution, work-related agents, infections, and obesity...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/30382605/a-machine-learning-approach-to-predicting-need-for-hospitalization-for-pediatric-asthma-exacerbation-at-the-time-of-emergency-department-triage
#2
Shilpa J Patel, Daniel B Chamberlain, James M Chamberlain
OBJECTIVES: Pediatric asthma is a leading cause of emergency department (ED) utilization and hospitalization. Earlier identification of need for hospital-level care could triage patients more efficiently to high- or low-resource ED tracks. Existing tools to predict disposition for pediatric asthma use only clinical data, perform best several hours into the ED stay, and are static or score-based. Machine learning offers a population-specific, dynamic option that allows real-time integration of available nonclinical data at triage...
November 1, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/30285942/clara-cell-protein-16-release-from-the-nasal-mucosa-in-allergic-rhinitis-chronic-rhinosinusitis-and-exposure-to-air-pollutants
#3
Aleksandar Perić, Cveta Špadijer Mirković, Danilo Vojvodić
Clara cell protein 16 (CC16) is a small protein mainly produced by non-ciliated Clara cells in the respiratory epithelium. It has an anti-inflammatory role in chronic upper and lower airway eosinophilic inflammations. Decreased levels of CC16 are found in the nasal secretions and plasma of patients with chronic eosinophilic inflammatory disorders, such as asthma, allergic rhinitis, and chronic rhinosinusitis with or without nasal polyps, as well as in people exposed to high levels of air pollutants. Intranasal corticosteroid administration suppresses chronic inflammation of the nasal mucosa driven by eosinophils and stimulates local CC16 production...
September 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29721586/corticosteroid-binding-globulin-induced-in-testicular-leydig-cells-by-perfluorooctanoic-acid-promotes-steroid-hormone-synthesis
#4
Sujie Sun, Jianshe Wang, Yin Lu, Jiayin Dai
Perfluorooctanoic acid (PFOA) is an abundant perfluoroalkyl substance widely applied in industrial and consumer products. It is a ubiquitous environmental pollutant and suspected endocrine disruptor. Corticosteroid-binding globulin (CBG) is a monomeric glycoprotein that can bind specifically to anti-inflammatory steroids, such as glucocorticoids and progesterone, in circulation. Our previous proteomic profile analysis revealed that CBG levels increased in testes after PFOA treatment. In the present study, we verified its increase in mouse testes following oral exposure to PFOA (0, 1...
June 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29423374/the-international-study-of-the-allergic-rhinitis-survey-outcomes-from-4-geographical-regions
#5
Desiderio Passali, Cemal Cingi, Paola Staffa, Francesco Passali, Nuray Bayar Muluk, Maria Luisa Bellussi
Background: Allergic rhinitis (AR) is a global health problem and is characterised by one or more symptoms, including sneezing, itching, nasal congestion and rhinorrhea. Objective: We investigated the features of AR and the physician's approach to the management of AR patients in four geographical regions. Methods: In this cross-sectional study, a questionnaire survey concerning AR was completed by Honorary and Corresponding Members of the Italian Society of Rhinology from different countries among 4 world geographical regions-Asia, Europe, the Americas, and Africa...
January 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28696794/the-effects-of-asthma-medications-on-reactive-oxygen-species-production-in-human-monocytes
#6
Ming-Kai Tsai, Yi-Ching Lin, Ming-Yii Huang, Min-Sheng Lee, Chang-Hung Kuo, Po-Lin Kuo, Ching-Hsiung Lin, Chih-Hsing Hung
OBJECTIVE: Asthma is a chronic inflammatory airway disease induced by many environmental factors. The inhalation of allergens and pollutants promotes the production of reactive oxygen species (ROS) leading to airway inflammation, hyper-responsiveness, and remodeling in allergic asthma. The effects of asthma medications on ROS production are unclear. The present study investigated the anti-ROS effects of current asthma medications including inhaled corticosteroid (ICS; budesonide and fluticasone), leukotriene receptor antagonist (LTRA; montelukast), long-acting β2 agonists (LABAs; salmeterol and formoterol), and a new extra-LABA (indacaterol)...
April 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28677244/endocrine-disruption-in-silico-interactions-between-phthalate-plasticizers-and-corticosteroid-binding-globulin
#7
Ishfaq A Sheikh, Mohd A Beg
Endocrine disruption is a phenomenon when a man-made or natural compound interferes with normal hormone function in human or animal body systems. Endocrine-disrupting compounds (EDCs) have assumed considerable importance as a result of industrial activity, mass production of synthetic chemicals and environmental pollution. Phthalate plasticizers are a group of chemicals used widely and diversely in industry especially in the plastic industry, and many of the phthalate compounds have endocrine-disrupting properties...
December 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28349353/management-of-chronic-obstructive-pulmonary-disease-in-patients-with-cardiovascular-diseases
#8
REVIEW
Mario Cazzola, Luigino Calzetta, Barbara Rinaldi, Clive Page, Giuseppe Rosano, Paola Rogliani, Maria Gabriella Matera
Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases often coexist. The mechanistic links between these two diseases are complex, multifactorial and not entirely understood, but they can influence the therapeutic approach. Therapy can be primarily directed towards treating the respiratory symptoms and reducing lung inflammation. Smoking cessation, bronchodilators and inhaled corticosteroids are central to this therapeutic approach. The underlying pathophysiological mechanisms that are responsible for the increased cardiovascular risk in COPD remain unclear, but might include arterial stiffness, inflammation and endothelial dysfunction as a consequence of systemic exposure to chemicals in cigarette smoke or airborne pollution...
May 2017: Drugs
https://www.readbyqxmd.com/read/27764878/environmental-and-genetic-risk-factors-associated-with-venous-thromboembolism
#9
REVIEW
Marta Crous-Bou, Laura B Harrington, Christopher Kabrhel
Venous thromboembolism (VTE) includes deep vein thrombosis and pulmonary embolism, and a combination of environmental and genetic risk factors contributes to VTE risk. Within environmental risk factors, some are provoking (e.g., cancer, surgery, trauma or fracture, immobilization, pregnancy and the postpartum period, long-distance travel, hospitalization, catheterization, and acute infection) and others are nonprovoking (e.g., age, sex, race/ethnicity, body mass index and obesity, oral contraceptive or hormone therapy use, corticosteroid use, statin use, diet, physical activity, sedentary time, and air pollution)...
November 2016: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/27435763/-impact-of-premature-rupture-of-membranes-on-neonatal-complications-in-preterm-infants-with-gestational-age-37-weeks
#10
Shun-Yan Duan, Xiang-Yong Kong, Feng-Dan Xu, Hong-Yan Lv, Rong Ju, Zhan-Kui Li, Shu-Juan Zeng, Hui Wu, Xue-Feng Zhang, Wei-Peng Liu, Fang Liu, Hong-Bin Cheng, Yan-Jie Ding, Tie-Qiang Chen, Ping Xu, Li-Hong Yang, Su-Jing Wu, Jin Wang, Li Peng, Xiao-Lin Zhao, Hui-Xian Qiu, Wei-Xi Wen, Ying Li, Lan Li, Zheng Wen, Guo Guo, Feng Wang, Gai-Mei Li, Wei Li, Xiao-Ying Zhao, Yun-Bo Xu, Wen-Chao Chen, Huan Yin, Xiao-Liang Wang, Rui-Yan Shan, Mei-Ying Han, Chun-Yan Yang, Zhi-Chun Feng
OBJECTIVE: To investigate the effect of premature rupture of the membrane (PROM) on neonatal complications in premature infants. METHODS: The registration information of 7684 preterm infants with gestational age <37 weeks were collected from the cooperative units in the task group between January 1, 2014 to December 31, 2014. Specially trained personnel from each cooperative units filled in the unified form in a standardized format to record the gender, gestational age, birth weight, PROM, placental abruption, antenatal corticosteroid, Apgar score, amniotic fluid pollution, and complications of the infants...
June 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27428612/association-between-unconventional-natural-gas-development-in-the-marcellus-shale-and-asthma-exacerbations
#11
Sara G Rasmussen, Elizabeth L Ogburn, Meredith McCormack, Joan A Casey, Karen Bandeen-Roche, Dione G Mercer, Brian S Schwartz
IMPORTANCE: Asthma is common and can be exacerbated by air pollution and stress. Unconventional natural gas development (UNGD) has community and environmental impacts. In Pennsylvania, UNGD began in 2005, and by 2012, 6253 wells had been drilled. There are no prior studies of UNGD and objective respiratory outcomes. OBJECTIVE: To evaluate associations between UNGD and asthma exacerbations. DESIGN: A nested case-control study comparing patients with asthma with and without exacerbations from 2005 through 2012 treated at the Geisinger Clinic, which provides primary care services to over 400 000 patients in Pennsylvania...
September 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27189863/chronic-obstructive-pulmonary-disease
#12
REVIEW
Peter J Barnes, Peter G J Burney, Edwin K Silverman, Bartolome R Celli, Jørgen Vestbo, Jadwiga A Wedzicha, Emiel F M Wouters
Chronic obstructive pulmonary disease (COPD) is a common disease with high global morbidity and mortality. COPD is characterized by poorly reversible airway obstruction, which is confirmed by spirometry, and includes obstruction of the small airways (chronic obstructive bronchiolitis) and emphysema, which lead to air trapping and shortness of breath in response to physical exertion. The most common risk factor for the development of COPD is cigarette smoking, but other environmental factors, such as exposure to indoor air pollutants - especially in developing countries - might influence COPD risk...
December 3, 2015: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/26805715/update-on-molecular-mechanisms-of-corticosteroid-resistance-in-chronic-obstructive-pulmonary-disease
#13
REVIEW
Zhilong Jiang, Lei Zhu
Chronic obstructive pulmonary disease (COPD) is an inflammatory and irreversible pulmonary disorder that is characterized by inflammation and airway destruction. In recent years, COPD has become a global epidemic due to increased air pollution and exposure to cigarette smoke. Current therapeutics using bronchiodialator and anti-inflammatory corticosteroids are most widely used for all patients with persistent COPD, but these approaches are disappointing due to limited improvement in symptom control and survival rate...
April 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/26770669/ocular-itch-associated-with-allergic-conjunctivitis-latest-evidence-and-clinical-management
#14
REVIEW
Stacey Ackerman, Lisa M Smith, Paulo J Gomes
Allergic conjunctivitis is one of the most common allergic conditions worldwide. Its incidence is increasing due to changing climate, pollution, increased pollen loads, and the subject's heightened immunological sensitivity in response to these environmental changes. The pathophysiology predominantly involves immunoglobulin E-related mast-cell activation, with release of histamine and other mediators contributing to the propagation of the response by calling in other immune cells and further inflammation. This article presents the evolution of ocular allergy treatments, from vasoconstrictors, to antihistamines and mast-cell stabilizers, to the dual-acting agents, as well as corticosteroid and immunomodulatory options...
January 2016: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/26264162/endocrine-activity-of-persistent-organic-pollutants-accumulated-in-human-silicone-implants-dosing-in-vitro-assays-by-partitioning-from-silicone
#15
Dorothea Gilbert, Philipp Mayer, Mikael Pedersen, Anne Marie Vinggaard
Persistent organic pollutants (POPs) accumulated in human tissues may pose a risk for human health by interfering with the endocrine system. This study establishes a new link between actual human internal POP levels and the endocrine active dose in vitro, applying partitioning-controlled dosing from silicone to the H295R steroidogenesis assay: (1) Measured concentrations of POPs in silicone breast implants were taken from a recent study and silicone disks were loaded according to these measurements. (2) Silicone disks were transferred into H295R cell culture plates in order to control exposure of the adrenal cells by equilibrium partitioning...
November 2015: Environment International
https://www.readbyqxmd.com/read/26232481/acute-exacerbation-of-idiopathic-pulmonary-fibrosis-shifting-the-paradigm
#16
REVIEW
Christopher J Ryerson, Vincent Cottin, Kevin K Brown, Harold R Collard
The goal of this review is to summarise the clinical features, management, and prognosis of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF). AE-IPF has previously been defined based on clinical and radiological features that include the subacute onset of dyspnoea, bilateral ground glass changes on chest high-resolution computed tomography, and the absence of an identifiable aetiology. The annual incidence of AE-IPF is typically reported at 5-15%, but is less common in mild disease. Features of diffuse alveolar damage are present when a biopsy is performed...
August 2015: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/26226354/difficult-to-control-asthma-epidemiology-and-its-link-with-environmental-factors
#17
REVIEW
William J Sheehan, Wanda Phipatanakul
PURPOSE OF REVIEW: The aim of the present review was to discuss the epidemiology of inadequate asthma control with an examination of contributing environmental factors. RECENT FINDINGS: Despite advances in asthma therapies, a proportion of patients with asthma continue to have difficulty in gaining adequate asthma control. Asthma severity and control in childhood are of particular importance as they translate to asthma morbidity in adulthood. Children with comorbid severe allergic rhinitis were more likely to have uncontrolled asthma...
October 2015: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26167969/-acute-exacerbation-in-copd-and-asthma
#18
REVIEW
Nurhayat Yıldırım, Tunçalp Demir, Bilun Gemicioğlu, Esen Kıyan, Kıvılcım Oğuzülgen, Mehmet Polatlı, Sevgi Saryal, Abdullah Sayıner, Arzu Yorgancıoğlu, Sevim Bavbek, Gülfem E Çelik, Hakan Günen, Dilşad Mungan, Elif Şen, Haluk Türktaş, Füsun Yıldız
Chronic obstructive pulmonary disease (COPD) and asthma are airway diseases with acute exacerbations. Natural course of both disease are affected by exacerbations. COPD exacerbations may be caused by infections and other causes; indoor and outdoor pollution, cardiovascular diseases, asthma-COPD overlap syndrome, COPD- obstructive sleep apnea syndrome, pulmonary embolism, gastro-oesophageal reflux, anxiety-depression, pulmonary hypertension. Exposure to triggering factors, viral infections, treatment insufficiency may cause asthma exacerbations...
June 2015: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/26082624/novel-aspects-of-pathogenesis-and-regeneration-mechanisms-in-copd
#19
REVIEW
Edvardas Bagdonas, Jovile Raudoniute, Ieva Bruzauskaite, Ruta Aldonyte
Chronic obstructive pulmonary disease (COPD), a major cause of death and morbidity worldwide, is characterized by expiratory airflow limitation that is not fully reversible, deregulated chronic inflammation, and emphysematous destruction of the lungs. Despite the fact that COPD is a steadily growing global healthcare problem, the conventional therapies remain palliative, and regenerative approaches for disease management are not available yet. We aim to provide an overview of key reviews, experimental, and clinical studies addressing lung emphysema development and repair mechanisms published in the past decade...
2015: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/26070404/construction-of-sensitive-reporter-assay-yeasts-for-comprehensive-detection-of-ligand-activities-of-human-corticosteroid-receptors-through-inactivation-of-cwp-and-pdr-genes
#20
Sayoko Ito-Harashima, Kazuhiro Shiizaki, Masanobu Kawanishi, Koji Kakiuchi, Kana Onishi, Ryoichi Yamaji, Takashi Yagi
INTRODUCTION: The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) are members of the nuclear receptor superfamily and ligand-dependent transcription factors, whose major ligands are glucocorticoid and mineralocorticoid, so-called corticosteroids. The corticosteroids are a class of substances that include steroid hormones naturally produced in the adrenal cortex of vertebrates and analogues of these hormones that are synthesized in industry. They are involved in a wide range of physiological processes including stress and immune responses, and the regulation of carbohydrate metabolism, protein catabolism, sodium homeostasis, and inflammation...
July 2015: Journal of Pharmacological and Toxicological Methods
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