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Catalin Taraboanta, Heidi Britton, Anna Plotkin, Nazila Azordegan, Philip B Clement, C Blake Gilks
Outpatient endometrial biopsy can give false-negative results, with a 0.9% reported posttest probability for endometrial carcinoma (EC) after a negative result. Our objective was to determine if there has been any improvement in the performance characteristics of endometrial biopsy over the last 15 yr. All hysterectomy specimens with a diagnosis of EC or atypical hyperplasia (AH), reported between May 2011 and May 2015, were identified and cross-referenced for any negative endometrial sampling results during the 5 yr before hysterectomy...
December 3, 2018: International Journal of Gynecological Pathology
S Egloff, M Schneeberger, S Gobeli, C Krudewig, S Schmitt, I M Reichler, S Peterhans
The following case report describes the clinical and diagnostic procedure for suspected brucellosis infection in a dog. A 21 month old intact male Border Collie was presented with an enlarged right testicle and epididymis. The dog was imported to Switzerland from Germany at the age of three months, but was never abroad since then. Clinical and laboratory diagnostic investigation included bacteriology and histology. An initial serological evaluation by means of rapid slide agglutination test (RSAT) was negative...
December 2018: Schweizer Archiv Für Tierheilkunde
Manu N Capoor, Jan Lochman, Andrew McDowell, Jonathan E Schmitz, Martin Solansky, Martina Zapletalova, Todd F Alamin, Michael F Coscia, Steven R Garfin, Radim Jancalek, Filip Ruzicka, A Nick Shamie, Martin Smrcka, Jeffrey C Wang, Christof Birkenmaier, Ondrej Slaby
PURPOSE: The presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available...
December 1, 2018: European Spine Journal
Joseph Chen, Alyssa Wield, Shikha Bose, Elena Savilo, Nichole Mahnert, Matthew Siedhoff, Kelly Wright
STUDY OBJECTIVE: To evaluate if smooth muscle cells can be detected in pelvic washings at the time of intact hysterectomy. DESIGN: A multi-centered pilot cohort study (Canadian Task Force Classification of Study Design Class II-2). SETTING: Two academically affiliated tertiary referral centers. PATIENTS: Patients undergoing total hysterectomy for benign indications without morcellation by minimally invasive gynecologic surgeons were enrolled from January 2018 to July 2018...
November 28, 2018: Journal of Minimally Invasive Gynecology
Kamila R Irvine, Kristofor McCarty, Kirsten J McKenzie, Thomas V Pollet, Katri K Cornelissen, Martin J Toveé, Piers L Cornelissen
There is now a considerable body of evidence to suggest that internal representations of the body can be meaningfully separated into at least two general levels; body image as a perceptual construct and body schema as a motor metric. However, recent studies with eating disordered individuals have suggested that there may in fact be more interaction between these two representations than first thought. We aimed to investigate how body image might act to influence body schema within a typical, healthy population...
November 27, 2018: Neuropsychologia
Kalpalata Tripathy, Aparajita Mishra, Ajit K Singh, Pragnya L Panda, Arup Mahapatra, Anusaya Lenka
Context: Efficacy of immunocytochemistry (ICC) in determining molecular biomarkers like estrogen receptor (ER), progesterone receptors (PRs), and human epidermal growth factor receptor-2 (HER2). Aims: To evaluate biomarkers using ICC in breast cancer as per American Society of Clinical Oncology/College of American Pathology (ASCO/CAP) guidelines. Settings and Design: The study was conducted over a period of 2 years from September 2012 to August 2014 and is the first such study in eastern India...
October 2018: Journal of Cytology
Hongxia Sun, Ramya P Masand, Shobhanaben Jagdishbhai Patel, Vijayalakshmi Padmanabhan
BACKGROUND: Cervical cancer is caused by high-risk human papillomavirus (hrHPV). Though screening Pap test (PT) has reduced cancer mortality by detecting precursor lesions, there is now a move toward replacing screening PT with hrHPV testing. The aims of this study were to determine hrHPV negative rate in high grade squamous intraepithelial lesion (HSIL) PT in high-risk patients and correlate with histopathology; and to review the hrHPV negative HSIL PT. METHOD: LIS was searched (January 2015-June 2016) for HSIL PT results...
November 2018: Diagnostic Cytopathology
Matt Worges, Nicole Whitehurst, Emanuel Yamo, Hawela Moonga, Joshua Yukich, Luis Benavente
BACKGROUND: Accurate diagnosis of malaria and reduced reliance on presumptive treatment are crucial components of quality case management. From 2008 to 2012, the Improving Malaria Diagnostics project, in collaboration with the Zambia National Malaria Control Centre, implemented an external quality assurance scheme partially comprised of outreach training and supportive supervision (OTSS) in an effort to improve malaria case management across a spectrum of health facilities performing laboratory-based malaria diagnostics...
November 28, 2018: Malaria Journal
En-De Chu, Po-Hsiang Wang, Yi-Zhe Hong, Wei-Yen Woon, Hsiang-Chih Chiu
We have investigated the frictional properties of single-layer graphene (SLG) coated rough silica substrate under the influence of nano-confined hydration layer underneath SLG. Through the friction and surface potential measurements by atomic force microscopy (AFM), we found polygonal features in AFM images of SLG-protected silica surface that exhibit simultaneously larger friction and higher surface potential as compared to their surrounding areas due to water layers confined under SLG. Nano-confined water layers at the SLG-silica interface can induce the hole-doping effect in SLG, resulting in a more positively-charged and hydrophilic surface that favors adsorption of ambient water molecules...
January 25, 2019: Nanotechnology
B Tseveenjav, H D Blackburn, D J Garrick
Inbreeding has been shown to have negative effects on animal reproductive performance. It, however, has not been documented as to the extent that inbreeding impacts sperm cell characteristics especially after cells have undergone cryopreservation. In the present study, therefore, there was evaluation of sperm motion and size characteristics from two inbred lines and non-inbred Hereford bulls using Computer Assisted Sperm Analysis (CASA). Pre-frozen semen samples were obtained from Line 1, Prospector, and a non-inbred Hereford bulls...
December 2018: Animal Reproduction Science
Rika Yonekura, Tomo Osako, Takuji Iwase, Akiko Ogiya, Takayuki Ueno, Masanobu Kitagawa, Shinji Ohno, Futoshi Akiyama
PURPOSE: Ductal carcinoma in situ (DCIS)-preinvasive breast cancer-with lymph node metastasis can clinically be treated as different stages: occult invasive cancer with true metastasis (T1N1) or pure DCIS with iatrogenic dissemination (TisN0). In this retrospective cohort study, we aimed to elucidate the prognostic impact and possible pathogenesis of nodal metastasis in DCIS to improve clinical management. METHODS: Subjects were comprised of 427 patients with routine postoperative diagnosis of DCIS who underwent sentinel node (SN) biopsy using molecular whole-lymph-node analysis...
November 24, 2018: Breast Cancer Research and Treatment
Patrizia Straccia, Guido Fadda, Francesco Pierconti
OBJECTIVE: The current tools available for detecting malignant neoplasms in the cerebrospinal fluid (CSF) are neurologic examination, followed by neuroimaging, cytology and molecular techniques. To highlight the role of cytology the diagnosis of metastatic tumors in cerebrospinal fluid (CSF) samples, we present our experience using cytospin and ThinPrep liquid-based cytology (LBC). METHODS: A retrospective analysis was conducted using the pathological records of 8,181 cytological specimens of CSF which were diagnosed over a 17-year period...
November 23, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Tibor Tot
Eccrine ductal and acrosyringeal metaplasia was described in 2006 as the presence of tumor structures that resemble the epithelium of the eccrine skin ducts and their opening within the epidermis, the acrosyringeum. Here, we report the clinical, morphological, and phenotypic characteristics of eight breast carcinomas that we collected over the past years showing this metaplasia. Unlike squamous metaplasia, acrosyringeal and eccrine ductal metaplasia are luminated structures comprising cells with eosinophilic cytoplasm that are easily detectable in routine histological slides...
November 22, 2018: Virchows Archiv: An International Journal of Pathology
Mateus Flores Montalvão, Lorrana Lucas Gomes Sampaio, Huan Henrique Ferreira Gomes, Guilherme Malafaia
Smoked cigarette butt (SCB) discharged in the environment became an issue of unknown consequences for plants. Thus, we aim at assessing the impact of water containing SBC leachate on the meristem cells of Allium cepa roots. We defined the following experimental groups: negative control (water), positive control (cyclophosphamide); water with SCB leachate at environmental concentration (1.9 μg/L of nicotine) (EC1× group) and water with SCB leachate concentration 1000 times higher than EC1 (EC1000× group)...
November 20, 2018: Environmental Science and Pollution Research International
Yixun Li, Mina Maleki, Nicholas J Carruthers, Paul M Stemmer, Alioune Ngom, Luis Rueda
BACKGROUND: The prediction of calmodulin-binding (CaM-binding) proteins plays a very important role in the fields of biology and biochemistry, because the calmodulin protein binds and regulates a multitude of protein targets affecting different cellular processes. Computational methods that can accurately identify CaM-binding proteins and CaM-binding domains would accelerate research in calcium signaling and calmodulin function. Short-linear motifs (SLiMs), on the other hand, have been effectively used as features for analyzing protein-protein interactions, though their properties have not been utilized in the prediction of CaM-binding proteins...
November 20, 2018: BMC Bioinformatics
Luca Cima, Matteo Brunelli, Anil Parwani, Ilaria Girolami, Andrea Ciangherotti, Giulio Riva, Luca Novelli, Francesca Vanzo, Alessandro Sorio, Vito Cirielli, Mattia Barbareschi, Antonietta D'Errico, Aldo Scarpa, Chiara Bovo, Filippo Fraggetta, Liron Pantanowitz, Albino Eccher
Introduction: Whole-slide imaging (WSI) technology can be used for primary diagnosis and consultation, including intraoperative (IO) frozen section (FS). We aimed to implement and validate a digital system for the FS evaluation of cancer and transplant specimens following recommendations of the College of American Pathologists. Materials and Methods: FS cases were routinely scanned at ×20 employing the "Navigo" scanner system. IO diagnoses using glass versus digital slides after a 3-week washout period were recorded...
2018: Journal of Pathology Informatics
Chenchen Wang, Gangqiang Zhang, Zhipeng Li, Xiangqiong Zeng, Yong Xu, Shichang Zhao, Hongxing Hu, Yadong Zhang, Tianhui Ren
Titanium alloys (Ti-6Al-4V) are promising materials as bone implants in clinical surgeries owing to their excellent performances. However, wear debris caused by the tribological behavior of the cortical bone and titanium alloy interface were found to be paramount for implant stability. The contact environment between the cortical bone and Ti-6Al-4V in vivo has been considered to affect the tribological behavior. Currently, the tribological behaviors of bone and Ti-6Al-4V in different biolubricants remain elusive...
October 29, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Sruthi Babu, Daniel C Mockler, Lucia Roa-Peña, Agnieszka Szygalowicz, Nam W Kim, Sholeh Jahanfard, Shahram S Gholami, Richard Moffitt, John P Fitzgerald, Luisa F Escobar-Hoyos, Kenneth R Shroyer
There is a clinical need to identify novel biomarkers to improve diagnostic accuracy for the detection of urothelial tumors. The current study aimed to evaluate keratin 17 (K17), an oncoprotein that drives cell cycle progression in cancers of multiple anatomic sites, as a diagnostic biomarker of urothelial neoplasia in bladder biopsies and in urine cytology specimens. We evaluated K17 expression by immunohistochemistry in formalin-fixed, paraffin embedded tissue specimens of non-papillary invasive urothelial carcinoma (UC) (classical histological cases), high grade papillary UC (PUC-LG), low grade papillary UC (PUC-HG), papillary urothelial neoplasia of low malignant potential (PUNLMP), and normal bladder mucosa...
November 15, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Jan Heidkamp, Petra L M Zusterzeel, Adriana C H van Engen-van Grunsven, Christiaan G Overduin, Andor Veltien, Arie Maat, Maroeska M Rovers, Jurgen J Fütterer
In the surgical treatment of vulvar squamous-cell carcinoma (VSCC), tumor-free margins of 8 mm or more are considered adequate. However, limited perioperative information on the tumor-free margins other than the surgeon's own estimation is available. The purpose of this study was therefore to investigate the feasibility of ex vivo MRI in localizing VSCC and to assess the surgical tumor-free margins in fresh radical local excision (RLE) specimens to guide the surgeon during resections. Nine patients with biopsy-proven VSCC scheduled for RLE were prospectively included...
November 15, 2018: NMR in Biomedicine
Mohammad Mehdi Dehghani Firoozabadi, Abbas Alibakhshi, Hoorieh Alaeen, Sanaz Zand, Ryan Nazemian, Maryam Rahmani
Background: Intra-abdominal adhesion is one of the most important complications of abdominopelvic surgery. It increases morbidity and mortality for patients. Although laparoscopy is the gold standard of adhesion diagnosis, it can cause visceral damage during the operation. Therefore, surgeons prefer to use non-invasive methods for planning the operation. We designed this study to evaluate transabdominal ultrasonography ( TAU) accuracy for diagnosing Intra-abdominal Adhesions. Material & methods: This double-blinded cohort study was conducted on 47 patients with previous laparotomy who undergo another surgery...
December 2018: Annals of Medicine and Surgery
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