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Hua Yao, Jinqi Ma
The present paper investigates the enhancement of the therapeutic effect of Paclitaxel (a potent anticancer drug) by increasing its cellular uptake in the cancerous cells with subsequent reduction in its cytotoxic effects. To fulfill these goals the Paclitaxel (PTX)-Biotinylated PAMAM dendrimer complexes were prepared using biotinylation method. The primary parameter of Biotinylated PAMAM with a terminal HN2 group - the degree of biotinylation - was evaluated using HABA assay. The basic integrity of the complex was studied using DSC...
2018: Acta Biochimica Polonica
Masato Ohara, Ryo Oda, Shogo Toyama, Yusei Katsuyama, Hiroyoshi Fujiwara, Toshikazu Kubo
INTRODUCTION: Closed flexor tendon rupture after a malunited distal radius fracture is rare and usually becomes apparent early after the fracture. Most cases are accompanied by a severe distal radio-ulnar joint capsule injury, wherein bone protrusion (as a spur) directly stresses the tendons. We experienced a nonspecific flexor tendon rupture associated with an old fracture and the presence of collagen disease. PRESENTATION OF CASE: A 63-year-old woman presented with delayed complete rupture of the flexor digitorum profundus (FDP) of the fifth digit...
May 29, 2018: International Journal of Surgery Case Reports
Jameason D Cameron, Éric Doucet, Kristi B Adamo, Mark Walker, Alessandro Tirelli, Joel D Barnes, Kaamel Hafizi, Marisa Murray, Gary S Goldfield
BACKGROUND: Maternal prenatal smoking is associated with downstream childhood obesity. Although animal research suggests reduced resting energy expenditure (REE), decreased physical activity (PA), and increased energy intake as mechanisms, these relationships are unclear in humans. The objectives were to examine the association of prenatal maternal smoking with non-volitional energy expenditure (REE and the thermic effect of feeding [TEF]), child adiposity, energy intake, free-living PA (daily light PA (LPA), daily moderate-to-vigorous PA (MVPA), daily sedentary behavior (SB)), and screen time (television and computer/video game) in children...
June 15, 2018: Physiology & Behavior
Cheryl Geisthardt, Adam Kloha
Results of a pilot study examining young adults' beliefs about what factors contribute to physical and mental health are reported. Existing research and the results of the pilot study are used to argue for the need for improved education on the connection between physical and mental health, the impact of social determinants on physical and mental health, and the potential for social policies that better the lives of children and families to improve health outcomes. Benefits of and suggestions for increasing understanding of social determinants and social policies on physical and mental health are explored...
June 18, 2018: Social Work in Public Health
Jane M Ussher, Janette Perz, Duncan Rose, Andrew Kellett, Gary Dowsett
The use of assistive aids in sexual rehabilitation after prostate cancer (PCa) was examined in 124 gay, bisexual, and other men who have sex with men (GBM) and 225 heterosexual men. GBM were significantly more likely to use assistive aids (79% versus 56%), to try multiple assistive aids (M = 1.65 versus M = 0.83) including medication, penile injection, penile implant, vacuum pump, and nonmedical sex aids, and to seek information about sexual rehabilitation on the Internet, through counseling, or in a support group...
June 18, 2018: Journal of Sex Research
Joseph Jankovic, Ira Goodman, Beth Safirstein, Tonya K Marmon, Dale B Schenk, Martin Koller, Wagner Zago, Daniel K Ness, Sue G Griffith, Michael Grundman, Jay Soto, Susanne Ostrowitzki, Frank G Boess, Meret Martin-Facklam, Joseph F Quinn, Stuart H Isaacson, Omid Omidvar, Aaron Ellenbogen, Gene G Kinney
Importance: Aggregated α-synuclein is believed to be central to the pathogenesis of Parkinson disease (PD). PRX002/RG7935 (PRX002) is a humanized monoclonal antibody designed to target aggregated forms of α-synuclein, thereby inhibiting neuron-to-neuron transfer of presumed pathogenic forms of α-synuclein, potentially resulting in neuronal protection and slowing disease progression. Objective: To evaluate the safety and tolerability of multiple intravenous infusions of PRX002 in patients with idiopathic PD...
June 18, 2018: JAMA Neurology
Becky Marquez, Greg Norman, James Fowler, Kim Gans, Bess Marcus
OBJECTIVE: Despite data linking the social environment to physical inactivity in Latinas, research on social network predictors of physical activity (PA) is limited. This study examined social network predictors of PA change in Latinas. METHODS: Egocentric network data were collected from 102 adult Latinas (egos) participating in a randomized controlled PA intervention trial for underactive women. Moderate-to-vigorous PA (MVPA) was measured in minutes per week using the 7-Day PA Recall Interview and accelerometers at baseline and 12 months...
2018: PloS One
Gregorio González-Alcaide, Alejandro Salinas, José M Ramos
BACKGROUND: Chagas cardiomyopathy is a serious and common complication of Chagas disease. METHODS: Through bibliometric and Social Network Analysis, we examined patterns of research on Chagas cardiomyopathy, identifying the main countries, authors, research clusters, and topics addressed; and measuring the contribution of different countries. RESULTS: We found 1932 documents on Chagas cardiomyopathy in the MEDLINE database. The most common document type was 'journal article', accounting for 79...
June 18, 2018: PLoS Neglected Tropical Diseases
Mark Stevens, Tim Rees, Remco Polman
Growing evidence suggests that social identities may have profound implications for physical activity participation. Real-world examinations of this relationship have, however, been lacking, with research predominantly examining intentions and hypothetical scenarios. To address this shortcoming and further advance understanding in this area, the present study tested relationships between group identification, participation, two exercise-specific outcomes (exercise-specific satisfaction and group cohesion), and a broad health indicator (life satisfaction) among individuals recruited from parkrun...
June 18, 2018: Journal of Sports Sciences
Andrew Miller, Narelle Eather, Mitch Duncan, David Revalds Lubans
This study investigated if object control relates to children's game play competence, and examined these competencies as correlates of physical activity and cardiorespiratory fitness. Game play (Game Performance Assessment Instrument), object control (The Test Gross Motor Development-3), moderate-to-vigorous physical activity (Accelerometry), and cardiorespiratory fitness (20-metre shuttle) assessments were completed for 107 children (57% Female, 43% Male) aged 9-12 years (M 10.53, SD 0.65). Two-level regression of object control on game play competence, and object control and game play competence on physical activity and cardiorespiratory fitness assessed associations...
June 18, 2018: Journal of Sports Sciences
Sarah-Grace Paguinto, Nadine A Kasparian, Paula Bray, Michelle Farrar
PURPOSE: To conduct a scoping review of the published evidence on parents' perceptions of power wheelchair prescription for children with a neuromuscular disorder and clinicians' influence on timely wheelchair implementation. METHOD: Nine electronic databases and reference lists of all retrieved full-text articles were searched up to March 2017. Eligibility criteria included (1) at least one child participant with a neuromuscular disorder, (2) power wheelchair as an intervention, and (3) qualitative, quantitative or mixed methods parent-reported outcomes related to power wheelchair equipment...
June 18, 2018: Disability and Rehabilitation
Jinbo He, Xitao Fan, Jinjin Yan, Fang Huang, Wen Wu, Zhihui Cai
Night Eating Syndrome has been shown to be associated with various negative physical and psychological consequences. This study explored the relationship between neuroticism and night eating, which had not been studied before. We also examined the possible mediating roles of psychological distress and maladaptive coping for the relationship between neuroticism and night eating. A sample of 578 Chinese college students were assessed on several measures: The Revised Eysenck Personality Questionnaire Short Scale, the Night Eating Questionnaire, the Depression Anxiety Stress Scales, and the Simplified Coping Style Questionnaire...
June 18, 2018: Psychology, Health & Medicine
Kevin J Morris, Anita H Corbett
The polyadenosine RNA-binding protein ZC3H14 is important in RNA processing. Although ZC3H14 is ubiquitously expressed, mutation of the ZC3H14 gene causes a non-syndromic form of intellectual disability. Here, we examine the function of ZC3H14 in the brain by identifying ZC3H14-interacting proteins using unbiased mass spectrometry. Through this analysis, we identified physical interactions between ZC3H14 and multiple RNA processing factors. Notably, proteins that comprise the THO complex were amongst the most enriched proteins...
June 15, 2018: Nucleic Acids Research
E L Deters, R S Stokes, O N Genther-Schroeder, S L Hansen
Thirty-six newly weaned, crossbred beef steers (323 ± 12 kg; SD) from a single-source were used in a 56-d study to examine the effects of a Saccharomyces cerevisiae fermentation product (SCFP; Original XPC, Diamond V, Cedar Rapids, IA) on total tract nutrient digestibility and response to a vaccination challenge. Twelve d after arrival, steers were blocked by body weight (BW) and randomly assigned to treatments: SCFP at 0 (CON), 14 (SCFP14), or 28 (SCFP28) g·steer-1·d-1. Steers were fed via bunks that measured individual intake and received ear tags (CowManager, Select Sires, Plain City, OH) that recorded rumination and activity...
June 15, 2018: Journal of Animal Science
Yassine Negra, Helmi Chaabene, Jaime Fernandez-Fernandez, Senda Sammoud, Raja Bouguezzi, Olaf Prieske, Urs Granacher
Negra, Y, Chaabene, H, Fernandez-Fernandez, J, Sammoud, S, Bouguezzi, R, Prieske, O, and Granacher, U. Short-term plyometric jump training improves repeated-sprint ability in prepuberal male soccer players. J Strength Cond Res XX(X): 000-000, 2018-This study examined the effects of a short-term (i.e., 8 weeks) combined horizontal and vertical plyometric jump training (PJT) program in combination with regular soccer-specific training as compared with soccer-specific training only on jump and change of direction (CoD) performances, speed, and repeated-sprint ability (RSA) in prepuberal male soccer players...
June 14, 2018: Journal of Strength and Conditioning Research
Nicholas A Ross, Miriam L Vega, Matthew S Keller
Dermatology was consulted in the care of a 58-year-old man with a history of paranoid schizophrenia, neuroleptic malignant syndrome, a positive purified protein derivative test, and a lack of bathing for approximately 4 years who had been admitted to the hospital because of thick, crusted lesions over an increasing portion of his body. Admitted involuntarily, he was disinterested in the history, physical examination, and diagnostic testing. Comorbid schizophrenia presented a unique challenge because he was unable to participate in his care effectively...
2018: Skinmed
Cristiane Decat Bergerot, Karen Lynn Clark, Kimlin Tam Ashing, Paulo Gustavo Bergerot, Richard Obenchain, Nazli Dizman, JoAnn Hsu, Errol Philip, Matthew Loscalzo, Sumanta Kumar Pal
OBJECTIVE: Limited research exists examining the biopsychosocial experience of patients diagnosed with metastatic renal cell carcinoma (mRCC), a disease commonly associated with a poor prognosis. The purpose of this study was to describe rates and types of distress in mRCC patients and explore the relationship between distress and overall survival. METHOD: A cohort of 102 patients with mRCC treated at a single institution was assessed by a touch screen-based instrument comprising 22 core items spanning physical, practical, functional, and emotional domains...
June 18, 2018: Palliative & Supportive Care
Cynthia Fraga Rizo, Jennifer O'Brien, Christopher Wretman, Ashley Givens, Kirsten Kainz, Brittney Chesworth
Research indicates women who perpetrate intimate partner violence (IPV) experience both more frequent and more severe IPV victimization. However, the IPV field needs additional research to understand the complex relationship between various forms of IPV victimization (e.g., psychological, physical, sexual) and IPV perpetration by women. In particular, the field needs a better understanding of the unique interplay of various forms of IPV victimization and perpetration among female system-involved survivors (i...
June 1, 2018: Journal of Interpersonal Violence
Adegbenga M Sunmola, Olusegun A Mayungbo, Olufunke A Fayehun, Remi S Opayemi, Luqman A Morakinyo
Husband's controlling and domineering attitudes have been shown to contribute to women's intimate partner violence experience in Nigeria. Some scholars have suggested that women's safer sex negotiation may create additional opportunity for incurring partner violence. The purpose of the current study was to test the possibility that married women's tendency to negotiate safer sex would contribute significant additional proportions of the variance in their experience of physical, sexual, and emotional violence...
June 1, 2018: Journal of Interpersonal Violence
Nelson Roy, Kristine M Tanner, Ray M Merrill, Charisse Wright, Jenny L Pierce, Karla L Miller
OBJECTIVE: This investigation examined the prevalence, symptoms, risk factors, and quality-of-life burden of swallowing disorders in rheumatoid arthritis (RA), a chronic, progressive autoimmune inflammatory disease. METHODS: One hundred individuals with RA (84 women, 16 men; mean age = 61.1 years, SD = 13.1) were interviewed regarding the presence, nature, and impact of swallowing symptoms and disorders. Associations between swallowing disorders, medical factors, RA disease severity, and quality of life were examined...
June 1, 2018: Annals of Otology, Rhinology, and Laryngology
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