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https://www.readbyqxmd.com/read/29036230/predictors-of-adverse-drug-reaction-related-hospitalisation-in-southwest-ethiopia-a-prospective-cross-sectional-study
#1
Mulugeta Tarekegn Angamo, Colin Michael Curtain, Leanne Chalmers, Daniel Yilma, Luke Bereznicki
BACKGROUND: Adverse drug reactions (ADRs) are important causes of morbidity and mortality in the healthcare system; however, there are no studies reporting on the magnitude and risk factors associated with ADR-related hospitalisation in Ethiopia. OBJECTIVES: To characterise the reaction types and the drugs implicated in admission to Jimma University Specialized Hospital, Southwest Ethiopia, and to identify risk factors associated with ADR-related hospitalisation...
2017: PloS One
https://www.readbyqxmd.com/read/29034702/taking-a-comprehensive-health-history-learning-through-practice-and-reflection
#2
Shirley Ingram
Taking a comprehensive health history is a core competency of the advanced nursing role. The purpose of the health history is to source important and intimate knowledge about the patient and allow the nurse and patient to establish a therapeutic relationship. Reflective practice, a core value of nursing in Ireland, means learning from experience. This article demonstrates how a recorded comprehensive health history simulation, coupled with reflection, provided insight into an advanced nurse practitioner's history-taking skills, thereby enhancing clinical practice...
October 12, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29033239/socioeconomic-factors-health-behavior-and-late-stage-diagnosis-of-breast-cancer-considering-the-impact-of-delay-in-diagnosis
#3
Mostafa Dianatinasab, Mohammad Mohammadianpanah, Nima Daneshi, Mohammad Zare-Bandamiri, Abbas Rezaeianzadeh, Mohammad Fararouei
BACKGROUND: Stage of cancer at diagnosis is one of the most important factors in patient prognosis. By controlling for diagnostic delay, this study aimed to identify factors associated with late-stage breast cancer (BC). PATIENTS AND METHODS: From November 2014 to January 2017, required information on 497 patients who were newly diagnosed with BC was obtained from patients' medical records. Logistic regression was used to measure the association between cancer stage and study variables...
September 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29032634/prevalence-of-hepatitis-c-infection-and-its-associated-factors-in-healthy-adults-without-identifiable-route-of-transmission
#4
Ngai Sze Wong, Cheuk Kwong Lee, Siu Cheung Ng, Hoi Kei Wong, Denise P C Chan, Shui Shan Lee
While hepatitis C virus (HCV) infection is long known to be associated with parenteral exposure, the specific route of transmission is not identified in a proportion of infected patients. Taking blood donors as the surrogate of healthy adults in the community in Hong Kong, we identified 91 HCV infected donors (≤0.02% positive rate) in 2014-2016, of whom 46 were recruited in a mixed method study to examine their transmission routes. A majority (75%) of the recruited donors were HCV RNA positive, with the predominant subtypes being 1b and 6a...
October 15, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29031233/forensic-and-clinical-significance-of-serum-amylase-lipase-and-gamma-glutamyl-transferase-as-predictors-of-outcome-in-head-injured-patients
#5
Mona Mohamed Abo El-Noor, Naema Mahmoud ElHosary, Hytham Ibrahim Elatrozy, Hussein Mohamed Abou Elgheit, Ahmed Mohamed Elbelkasy, Ahmed Gamal Fath, Ghada Hamed El-Shafy
Head trauma is one of the leading causes of death and disability worldwide. Combined head lesions consist of more than one form of lesions. Biochemical markers of brain injury are used in determining the extent of brain injury and predicting its outcomes. The aim of this study was to investigate the forensic and clinical significance of serum amylase, lipase and gamma glutamyl transferase (GGT) as predictors of the outcome in head injured patients. PATIENTS AND METHODS: Sixty head injured patients were enrolled and subjected to personal history taking, general and local physical examination...
October 4, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29031192/growth-and-endocrine-function-in-children-with-dravet-syndrome
#6
Krista Eschbach, Sharon Scarbro, Elizabeth Juarez-Colunga, Victoria Allen, Stephanie Hsu, Kelly Knupp
PURPOSE: Dravet syndrome is an intractable childhood epilepsy syndrome most often associated with an SCN1A mutation. In our clinical practice, several patients with Dravet syndrome were noted to have short stature and endocrine dysfunction. This has not been reported in the literature. Our study aim was to describe growth measurements and endocrine abnormalities in children with Dravet syndrome. METHOD: A retrospective chart review was performed at a single institution...
September 29, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29030804/a-multi-stage-representation-of-cell-proliferation-as-a-markov-process
#7
Christian A Yates, Matthew J Ford, Richard L Mort
The stochastic simulation algorithm commonly known as Gillespie's algorithm (originally derived for modelling well-mixed systems of chemical reactions) is now used ubiquitously in the modelling of biological processes in which stochastic effects play an important role. In well-mixed scenarios at the sub-cellular level it is often reasonable to assume that times between successive reaction/interaction events are exponentially distributed and can be appropriately modelled as a Markov process and hence simulated by the Gillespie algorithm...
October 13, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29030249/sex-as-a-biological-variable-drug-use-and-abuse
#8
Anthony L Riley, Briana J Hempel, Matthew M Clasen
The study of sex as a biological variable is a necessary emphasis across a wide array of endpoints, including basic neuroscience, medicine, mental health, physiology and behavior. The present review summarizes work from clinical and preclinical populations on sex differences in drug use and abuse, ranging from initiation to escalation/dysregulation and from drug cessation/abstinence to relapse. These differences are analyzed in the context of the addiction cycle conceptualization of Koob and his colleagues and address patterns of drug use (binge/intoxication), motivation underlying its use (withdrawal/negative affect) and likelihood and causes of craving and relapse of drug taking (anticipation/preoccupation)...
October 10, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29029621/uncertainty-on-the-effectiveness-and-safety-of-rivaroxaban-in-premenopausal-women-with-atrial-fibrillation-empirical-evidence-needed
#9
Herbert J A Rolden, Angela H E M Maas, Gert Jan van der Wilt, Janneke P C Grutters
BACKGROUND: Novel anticoagulations (NOACs) are increasingly prescribed for the prevention of stroke in premenopausal women with atrial fibrillation. Small studies suggest NOACs are associated with a higher risk of abnormal uterine bleeds than vitamin K antagonists (VKAs). Because there is no direct empirical evidence on the benefit/risk profile of rivaroxaban compared to VKAs in this subgroup, we synthesize available indirect evidence, estimate decision uncertainty on the treatments, and assess whether further research in premenopausal women is warranted...
October 13, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29028525/risk-taking-and-adult-attention-deficit-hyperactivity-disorder-a-gap-between-real-life-behavior-and-experimental-decision-making
#10
Yehuda Pollak, Reut Shalit, Adi Aran
Adults with attention deficit/hyperactivity disorder (ADHD) are prone to suboptimal decision making and risk taking. The aim of this study was to test performance on a theoretically-based probabilistic decision making task in well-characterized adults with and without ADHD, and examine the relation between experimental risk taking and history of real-life risk-taking behavior, defined as cigarette, alcohol, and street drug use. University students with and without ADHD completed a modified version of the Cambridge Gambling Test, in which they had to choose between alternatives varied by level of risk, and reported their history of substance use...
October 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29028228/preventing-emergence-of-drug-resistant-tuberculosis-in-myanmar-s-transitioning-health-system
#11
Mishal S Khan, Coll Hutchison, Richard J Coker, Joanne Yoong, Khaung M Hane, Anh L Innes, Tin M Khaing, Sithu Aung
Multidrug-resistant tuberculosis (MDR-TB) is a particular threat to the populations of resource-limited countries. Although inadequate treatment of TB has been identified as a major underlying cause of drug resistance, essential information to inform changes in health service delivery and policy is missing. We investigate factors that may be driving the emergence of MDR-TB in Myanmar, a country where investment and health system reforms are ongoing to address the unexplained, high occurrence of MDR-TB. We conducted a multi-centre, retrospective case-control study in 10 townships across Yangon...
October 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29026886/clinical-characteristics-of-acute-drug-induced-dystonia-in-pediatric-patients
#12
Hyun Woong Park, Jae Ryung Kwak, Ji Sook Lee
OBJECTIVE: Dystonia is a movement disorder in which muscles contract uncontrollably. Acute drug-induced dystonia (DID) can be diagnosed through detailed history taking and physical examination. This study aimed to identify the clinical characteristics of DID in children, which could help emergency physicians diagnose these conditions more efficiently. METHODS: We reviewed medical records of children aged below 18 years diagnosed with drug-related dystonia after discharge from the emergency department over 10 years...
September 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29026839/missing-the-benefit-of-metformin-in-acute-myeloid-leukemia-a-problem-of-contrast
#13
Alice C Ceacareanu, George K Nimako, Zachary A P Wintrob
OBJECTIVE: To evaluate whether metformin's cancer-related benefits reported in patients with solid tumors (ST) are also present in acute myeloid leukemia (AML) patients. METHODS: Baseline demographic and clinical history for all diabetes mellitus patients newly diagnosed with AML or cancer of the breast, ovary, prostate, gastrointestinal tract, lung, or kidney at Roswell Park Cancer Institute in Buffalo, NY (January 2003-December 2010, n = 924) was collected. Overall survival (OS) and disease-free survival (DFS) were assessed by Kaplan-Meier (KM) analysis and Cox proportional hazards regression (hazard ratio [HR])...
July 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29025138/relative-bioavailability-intranasal-abuse-potential-and-safety-of-benzhydrocodone-acetaminophen-compared-with-hydrocodone-bitartrate-acetaminophen-in-recreational-drug-abusers
#14
Sven M Guenther, Travis C Mickle, Andrew C Barrett, Kathryn Ann Roupe, Jing Zhou, Vincent Lam
Objectives: Benzhydrocodone is a hydrocodone prodrug that has been combined with acetaminophen (APAP) in a novel immediate-release analgesic. This study evaluated the relative bioavailability, intranasal abuse potential, and safety of benzhydrocodone/APAP compared with commercially available hydrocodone bitartrate (HB)/APAP. Design: Single-center, randomized, double-blind, double-dummy, two-part study comprising a Dose Selection (Part A) phase and a Main Study (Part B) phase...
August 25, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29024536/etanercept-induced-lymphocytic-infiltration-of-jessner-kanof
#15
Noémie Abbad, Tristan Lanal, Céline Brenuchon, Gauthier Morel, Xavier Deprez
The patient, a 52-year-old man presented a two-week history of asymptomatic multiple erythematous papules on the upper back (Panel A). The skin lesion had arisen 3 weeks after starting therapy with etanercept for axial spondyloarthritis. For several months, the patient had been taking NSAI and tramadol. A biopsy specimen from a lesion revealed a dense lymphocytic infiltrate of the superficial and mid-dermis (arrow) with perivascular and perifollicular distribution (Panel B). This article is protected by copyright...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29022699/scalable-high-affinity-stabilization-of-magnetic-iron-oxide-nanostructures-by-a-biocompatible-antifouling-homopolymer
#16
Giovanni Luongo, Paola Campagnolo, Jose Efrain Perez, Jurgen Kosel, Theoni K Georgiou, Anna Regoutz, David J Payne, Molly M Stevens, Mary P Ryan, Alexandra E Porter, Iain E Dunlop
Iron oxide nanostructures have been widely developed for biomedical applications, due to their magnetic properties and biocompatibility. In clinical application, the stabilization of these nanostructures against aggregation and non-specific interactions is typically achieved using weakly anchored polysaccharides, with better-defined and more strongly anchored synthetic polymers not commercially adopted due to complexity of synthesis and use. Here, we show for the first time stabilization and biocompatibilization of iron oxide nanoparticles by a synthetic homopolymer with strong surface anchoring and a history of clinical use in other applications, poly(2-methacryloyloxyethy phosphorylcholine) (poly(MPC))...
October 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29022191/the-association-between-subjectively-impaired-sleep-and-symptoms-of-depression-and-anxiety-in-a-frail-elderly-population
#17
Yan Press, Boris Punchik, Tamar Freud
BACKGROUND: Most previous studies showed an association between sleep impairment in the elderly and symptoms of depression and anxiety. Majority of these studies were conducted in "strong", community-dwelling elderly. AIM: To assess the association between subjective sleep impairment and its affective disturbances among frail elderly patients. METHODS: The retrospective study included patients 65 years old and above. Data included socio-demographic characteristics, the mini-mental state examination, the short anxiety screening test, the 15-item Geriatric Depression Scale, and the Patient Health Questionnaire...
October 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29021585/perceived-stress-level-and-risk-of-cancer-incidence-in-a-japanese-population-the-japan-public-health-center-jphc-based-prospective-study
#18
Huan Song, Eiko Saito, Norie Sawada, Sarah K Abe, Akihisa Hidaka, Taichi Shimazu, Taiki Yamaji, Atsushi Goto, Motoki Iwasaki, Shizuka Sasazuki, Weimin Ye, Manami Inoue, Shoichiro Tsugane
Evidence regarding stress as a risk factor for cancer onset is inconsistent. In this study, based on the Japan Public Health Center-based Prospective Study, we enrolled 101,708 participants aged 40-69 years from 1990-1994. The self-reported perceived stress level was collected at baseline and updated through 5-year follow-up. The association between perceived stress and cancer risk was measured by Cox proportional hazards regression model, adjusted for all known confounders. During follow-up (mean = 17...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021249/prescribing-ppis
#19
(no author information available yet)
Proton pump inhibitors (PPIs) are widely prescribed and many people remain on them for years. In some, there may be good justification for long-term use; for example, in those with oesophageal stricture, Barrett's oesophagus or a history of a bleeding gastrointestinal ulcer, or to provide gastroprotection in those at high risk of gastrointestinal complications from taking NSAIDs. However, PPIs are often not used in line with clinical guidelines.(1,2) In addition, there are concerns that many people take them for long periods to manage less serious conditions (e...
October 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/29020729/diagnosing-and-managing-androgen-deficiency-in-men
#20
Raveen Kaur Sandher, Jonathan Aning
Androgens play a crucial role in bone, muscle and fat metabolism, erythropoiesis and cognitive health. In men aged 40-79 years the incidence of biochemical deficiency and symptomatic hypogonadism is 2.1-5.7%. Decreased libido or reduced frequency and quality of erections, fatigue, irritability, infertility or a diminished feeling of wellbeing may be presenting complaints. However, a significant proportion of men with androgen deficiency will be identified when they present for unrelated concerns. Important factors to elicit from the history in addition to the presenting complaint include: a medical history of obesity, type 2 diabetes, systemic diseases or metabolic syndrome which all impact on testosterone physiology...
April 2017: Practitioner
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