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https://www.readbyqxmd.com/read/29457967/dna-damage-and-genomic-instability-among-workers-formerly-and-currently-exposed-to-asbestos
#1
Mirta Milić, Monica Neri, Marcello Ceppi, Marco Bruzzone, Armelle Munnia, Donatella Ugolini, Alfonso Cristaudo, Alessandra Bonotti, Marco E Peluso, Stefano Bonassi
Objectives Despite an asbestos ban in the European Union, exposure to asbestos still represents an occupational risk. Biomarkers of DNA damage and genomic instability in groups exposed to asbestos may contribute to the identification of subgroups/subjects at higher risk. Methods A cross-sectional study was conducted on 468 male individuals (80 working in occupational settings with potential exposure to asbestos fibers, 202 retired workers with past exposure, and 186 non-exposed controls) to compare genomic instability, cell proliferation and differentiation level using the non-invasive micronucleus buccal cytome assay...
February 19, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29457389/-study-on-the-risk-factors-for-the-misdiagnosis-of-femoral-head-osteonecrosis
#2
Zhi-Wei Chen, Tai-Xian Li, Xiao-Xu Wan, Rong-Tian Wang, Wei-Heng Chen
OBJECTIVE: To evaluate the status and risk factors for the misdiagnosis of femoral head osteonecrosis, providing the basis for accurate diagnosis of osteonecrosis of femoral head. METHODS: The data of 314 hospitalized patients were collected from March 2015 to March 2016, and the risk factors for osteonecrosis of femoral head were analyzed by Logistic regression model. Misdiagnosis was defined that the diagnosis given on the first time was different from that on the second time or that given by expert group with the same symptoms and signs...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455410/can-patients-with-symptomatic-tarlov-cysts-be-differentiated-from-patients-with-specific-low-back-pain-based-on-comprehensive-history-taking
#3
Maria Anna Hulens, Wim Dankaerts, Ricky Rasschaert, Frans Bruyninckx, Marie-Laure Willaert, Charlotte Vereecke, Greet Vansant
BACKGROUND: Tarlov cysts (TCs) are expanded nerve root sheaths that occur near the dorsal root ganglion and result from increased intraspinal hydrostatic pressure. TCs most frequently affect the lumbosacral plexus and therefore may cause specific symptoms such as perineal pain and neurogenic bladder, bowel, and sphincter problems. It has been estimated that 1% of the population has symptomatic Tarlov cysts (STCs). However, STCs appear to be underdiagnosed, with the pain reported by patients commonly attributed to degenerative alterations seen on MRI...
February 17, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29455213/outcomes-of-organ-transplantation-from-donors-with-a-cancer-history
#4
Shanzhou Huang, Yunhua Tang, Zebin Zhu, Jie Yang, Zhiheng Zhang, Linhe Wang, Chengjun Sun, Yixi Zhang, Qiang Zhao, Maogen Chen, Linwei Wu, Dongping Wang, Weiqiang Ju, Zhiyong Guo, Xiaoshun He
BACKGROUND The inherent challenges of selecting an acceptable donor for the increasing number and acuity of recipients has forced programs to take increased risks, including accepting donors with a cancer history (DWCH). Outcomes of organ transplantation using organs from DWCH must be clarified. We assessed transplant outcomes of recipients of organs from DWCH. MATERIAL AND METHODS Retrospective analysis of the Scientific Registry of Transplant Recipients data from January 1, 2000 to December 31, 2014 identified 8385 cases of transplants from DWCH...
February 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29453548/-big-data-from-clinical-routine
#5
REVIEW
U Mansmann
BACKGROUND: Over the past 100 years, evidence-based medicine has undergone several fundamental changes. Through the field of physiology, medical doctors were introduced to the natural sciences. Since the late 1940s, randomized and epidemiological studies have come to provide the evidence for medical practice, which led to the emergence of clinical epidemiology as a new field in the medical sciences. Within the past few years, big data has become the driving force behind the vision for having a comprehensive set of health-related data which tracks individual healthcare histories and consequently that of large populations...
February 16, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29453393/adherence-to-antiretroviral-therapy-and-factors-affecting-low-medication-adherence-among-incident-hiv-infected-individuals-during-2009-2016-a-nationwide-study
#6
Jungmee Kim, Eunyoung Lee, Byung-Joo Park, Ji Hwan Bang, Jin Yong Lee
For ideal clinical benefit, human immunodeficiency virus (HIV)-infected individuals should receive continuous medication. This is the first nationwide antiretroviral therapy (ART) adherence study in Asia, where medication monitoring at national level is systemically available. We estimated the ART adherence of incident HIV-infected individuals and investigated factors affecting low medication adherence using the national health insurance (NHI) claims data from 2007 to 2016. Medication possession ratio (MPR) was used to measure medication adherence and risk factors were identified by multivariable logistic regression analysis...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453328/management-of-atrial-fibrillation-in-patients-with-rheumatic-mitral-stenosis
#7
REVIEW
Bernard Iung, Antoine Leenhardt, Fabrice Extramiana
Atrial fibrillation (AF) is frequent in patients with rheumatic mitral stenosis (MS). Pressure overload leads to marked structural and electrical remodelling of left atrium. The frequency of persistent AF increases with age and paroxysmal, asymptomatic, AF seems even more frequent. The occurrence of AF worsens the haemodynamic tolerance of MS and markedly increases the risk of thromboembolic events. AF has a negative impact on the natural history of MS and on its outcome after commissurotomy. The respective indications of rhythm and rate control should be adapted to patient characteristics, particularly the consequences of MS, and take into account the high risk of recurrence of AF...
February 16, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29451524/-diet-and-gut-microbiota-two-sides-of-the-same-coin
#8
Ramona Schiumerini, Francesca Pasqui, Davide Festi
Gut microbiota is a complex ecosystem, resident in the digestive tract, exerting multiple functions that can have a significant impact on the pathophysiology of the host organism. The composition and functions of this "superorganism" are influenced by many factors, and among them, the host's dietary habits seem to have a significant effect. Dietary changes in the evolution of human history and in the different stages of life of the human subjects are responsible for qualitative and functional modification of gut microbiota...
January 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29450561/cognitive-performance-of-patients-with-chronic-heart-failure-on-sacubitril-valsartan-a-retrospective-cohort-study
#9
R De Vecchis, C Ariano, G Di Biase, M Noutsias
BACKGROUND: Sacubitril, a neprilysin inhibitor in the combination molecule sacubitril/valsartan, slows down degradation of endogenous natriuretic peptides, thereby enhancing their beneficial cardiovascular effects. However, sacubitril might also promote neuronal dysfunction and cognitive impairment in patients with chronic heart failure (CHF) treated with sacubitril/valsartan, due to possible neprilysin inhibition at the level of Central Nervous System. METHODS: A retrospective cohort study was undertaken to detect the effects exerted by sacubitril/valsartan on cognitive function in CHF patients...
February 15, 2018: Herz
https://www.readbyqxmd.com/read/29449164/patients-taking-%C3%AE-blockers-do-not-require-increased-doses-of-epinephrine-for-anaphylaxis
#10
Jennifer L White, Katie C Greger, Sangil Lee, Robert J Kahoud, James T Li, Christine M Lohse, Ronna L Campbell
BACKGROUND: β-Blocker use has been associated with increased anaphylaxis severity. OBJECTIVE: We aimed to assess for an association between β-blocker use and requirement for more than 1 dose of epinephrine for anaphylaxis management. METHODS: We conducted a retrospective observational study of patients seen in our emergency department for anaphylaxis between April 2008 and January 2015. The primary outcome measure was the number of doses of epinephrine...
February 13, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29447647/association-of-pemphigus-and-systemic-corticosteroid-use-with-comorbid-health-disorders-a-case-control-study
#11
Derek Y Hsu, Joaquin Brieva, Beatrice Nardone, Dennis West, Jonathan I Silverberg
BACKGROUND: Pemphigus is a group of debilitating autoimmune blistering disorders associated with painful blisters of the skin and/or mucous membranes. Identification and management of the comorbiditiesof pemphigus is critically important to minimize morbidity and decrease mortality. OBJECTIVE: To identify the comorbid health conditions of pemphigus vulgaris. METHODS: This was a case-control study of 130 cases of pemphigus verified by a clinical and laboratory diagnosis and 390 age and sex-matched controls with complete follow-up at a large metropolitanquaternary care medical center...
December 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447485/should-women-be-screened-for-osteoporosis-at-midlife
#12
T J de Villiers
Osteoporosis and associated fractures are common in women after midlife and will increase as the population ages. Osteoporosis-related fractures cause a significant increase in morbidity and mortality. Osteoporosis decreases the quality of life and productivity of many older women, with an increasing burden on health-care resources. Future risk of fracture can be managed by evidence-based interventions. It is thus appropriate to estimate the future risk of fracture in all women at the age of 50 years or at menopause, whichever occurs first...
February 15, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29447370/management-of-gout-by-uk-rheumatologists-a-british-society-for-rheumatology-national-audit
#13
Edward Roddy, Jon Packham, Karen Obrenovic, Ali Rivett, Joanna M Ledingham
Objectives: To assess the concordance of gout management by UK rheumatologists with evidence-based best-practice recommendations. Methods: Data were collected on patients newly referred to UK rheumatology out-patient departments over an 8-week period. Baseline data included demographics, method of diagnosis, clinical features, comorbidities, urate-lowering therapy (ULT), prophylaxis and blood tests. Twelve months later, the most recent serum uric acid level was collected...
February 13, 2018: Rheumatology
https://www.readbyqxmd.com/read/29447328/cardiac-surgery-in-adult-patients-with-remitted-or-active-malignancies-a-review-of-preoperative-screening-surgical-management-and-short-and-long-term-postoperative-results
#14
Roberto Lorusso, Enrico Vizzardi, Daniel M Johnson, Giovanni Mariscalco, Edoardo Sciatti, Jos Maessen, Elham Bidar, Sandro Gelsomino
Candidate patients for cardiac surgery procedures with a history of malignancies and antitumour therapy or with an active cancer and on antineoplastic treatment are increasingly common in daily practice. Oncological therapy can lead to cardiovascular injury and, therefore, has the potential for impacting operative risks and surgical strategies. This means that a number of considerations are essential to take into account prior to cardiac surgery. These include the type of cancer, previous cardiotoxicity or concomitant antitumour therapy, reversibility or irreversibility of such complications, the interaction between cancer disease course and extracorporeal circulation, the need for associated surgery and the impact of cancer on early and long-term outcomes...
February 13, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29446457/toward-a-multifactorial-model-of-expertise-beyond-born-versus-made
#15
David Z Hambrick, Alexander P Burgoyne, Brooke N Macnamara, Fredrik Ullén
The debate over the origins of individual differences in expertise has raged for over a century in psychology. The "nature" view holds that expertise reflects "innate talent"-that is, genetically determined abilities. The "nurture" view counters that, if talent even exists, its effects on ultimate performance are negligible. While no scientist takes seriously a strict nature-only view of expertise, the nurture view has gained tremendous popularity over the past several decades...
February 15, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29444628/assisting-the-investigation-of-stranger-rapes-predicting-the-criminal-record-of-u-k-stranger-rapists-from-their-crime-scene-behaviors
#16
Louise Almond, Michelle McManus, Amarat Bal, Freya O'Brien, Lee Rainbow, Mark Webb
Davies, Wittebrood, and Jackson (1997) were among the first to investigate whether offense behaviors are predictive of criminal history, with the findings of their paper then utilized by the National Crime Agency (NCA) Behavioral Investigative Advisors (BIAs) when assisting rape investigations. The aim of the study was to replicate this seminal paper with a larger contemporary sample of U.K. stranger rapists as identified by NCA. Data from 474 adult male stranger rapists were obtained in relation to 22 crime scene behaviors and nine preconviction variables...
February 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29443541/a-method-for-choosing-the-best-samples-for-mars-sample-return
#17
Peter R Gordon, Mark A Sephton
Success of a future Mars Sample Return mission will depend on the correct choice of samples. Pyrolysis-FTIR can be employed as a triage instrument for Mars Sample Return. The technique can thermally dissociate minerals and organic matter for detection. Identification of certain mineral types can determine the habitability of the depositional environment, past or present, while detection of organic matter may suggest past or present habitation. In Mars' history, the Theiikian era represents an attractive target for life search missions and the acquisition of samples...
February 14, 2018: Astrobiology
https://www.readbyqxmd.com/read/29441182/pediatric-cardiac-anamnesis-prevention-of-additional-diagnostic-tests
#18
REVIEW
Izet Masic, Zijo Begic, Nabil Naser, Edin Begic
Pediatrics is defined as the science of a healthy and sick child from birth to end of adolescence. Diseases of the cardiovascular system are the leading causes of mortality in adults, with frequent onset in childhood. The cardiologic examination starts with anamnesis in a pleasant atmosphere, refined space, enough time and patience, detailed measurements, and preferably a noncrying child. Anamnesis, regardless of the development of diagnostic procedures, still constitutes the basis of every clinical examination...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29441163/in-with-acute-bronchitis-out-with-duodenal-perforation-the-potentially-harmful-cascade-of-over-testing-a-case-report
#19
Karamjit Dhaliwal, Victoria Malkhasyan, Mohammed Elhassan
Overutilization of diagnostic imaging can lead to unnecessary interventions and subsequently can jeopardize patient safety. When ordered, the results of these images should always be interpreted in the appropriate clinical context taking into consideration the patient clinical presentation and the natural history of the diseases which are being investigated. We presented a case that demonstrates for the practicing physicians how violating these two notions can lead ultimately to patient harm.
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29439070/cross-sectional-analysis-of-the-prevalence-and-predictors-of-statin-utilisation-in-ireland-with-a-focus-on-primary-prevention-of-cardiovascular-disease
#20
Paula Byrne, John Cullinan, Catríona Murphy, Susan M Smith
OBJECTIVE: To describe the prevalence of statin utilisation by people aged over 50 years in Ireland and the factors associated with the likelihood of using a statin, focusing particularly on those using statins for primary prevention of cardiovascular disease (CVD). METHODS: This is a cross-sectional analysis of cardiovascular risk and sociodemographic factors associated with statin utilisation from wave 1 of The Irish Longitudinal Study on Ageing. A hierarchy of indications for statin utilisation, consisting of eight mutually exclusive levels of CVD-related diagnoses, was created...
February 8, 2018: BMJ Open
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