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https://www.readbyqxmd.com/read/29666951/predicting-chemotherapeutic-response-for-colorectal-liver-metastases-using-relative-tumor-enhancement-of-gadoxetic-acid-disodium-enhanced-magnetic-resonance-imaging
#1
Shinichi Murata, Shigeru Matsushima, Yozo Sato, Hidekazu Yamaura, Mina Kato, Takaaki Hasegawa, Kei Muro, Yoshitaka Inaba
PURPOSE: This study aimed to predict the treatment response for colorectal liver metastases (CLM) using relative tumor enhancement (RTE) of the hepatobiliary phase (HBP) for patients with no history of chemotherapy. MATERIALS AND METHODS: In this retrospective study, we enrolled 26 patients [14 males, 12 females; median age: 58 years (range 37-82 years)] with CLM and no history of chemotherapy between December 2011 and May 2017. Gadoxetic acid-enhanced magnetic resonance imaging was performed before starting chemotherapy and RTE of HBP...
April 17, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29665270/european-repository-of-explicit-criteria-of-potentially-inappropriate-medications-in-old-age
#2
Ivana Ivanova, Monique Elseviers, Maarten Wauters, Thierry Christiaens, Robert Vander Stichele
AIM: Lack of electronic assessment of medication lists in electronic health records is a barrier for more generalized use of potentially inappropriate medications (PIM) lists, designed for older adults. The aim was to construct a European repository of explicit criteria on PIM, suitable for electronic assessment. METHODS: PIM description, medication information, clinical information and level of evidence was entered. Criteria with unclear medication specifications were excluded...
April 17, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29664427/effect-of-statins-on-sirtuin-1-and-endothelial-nitric-oxide-synthase-expression-in-young-patients-with-a-history-of-premature-myocardial-infarction
#3
Aylin Hatice Yamaç, Ülkan Kılıç
OBJECTIVE: The present study was an investigation of the effect of statins on the expression of circulating sirtuin 1 (SIRT1) and endothelial nitric oxide synthase (eNOS) proteins, and on the distribution of single nucleotide polymorphisms (SNPs) of the SIRT1 gene in patients with a history of premature myocardial infarction (PMI). METHODS: A total of 108 patients who had suffered from a premature ST-elevation myocardial infarction (STEMI) under the age of 45 years were enrolled in this study...
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29662815/the-treatment-of-left-atrial-appendage-aneurysm-by-a-minimally-invasive-approach
#4
Young Woong Kim, Ho Jin Kim, Min Ho Ju, Jae Won Lee
Left atrial appendage (LAA) aneurysm is a rare, pathologic condition that may lead to atrial tachyarrhythmia or thromboembolic events. A 49-year-old man presented with aggravated palpitation and dizziness. He suffered from refractory atrial fibrillation despite a previous history of radiofrequency catheter ablation. Echocardiography revealed a 57-mm LAA aneurysm. Surgical ablation was performed through a right mini-thoracotomy, and the LAA aneurysm was obliterated with a 50-mm AtriClip (Atricure Inc., Westchester, OH, USA)...
April 2018: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29662507/new-predictors-of-in-stent-restenosis-in-patients-with-diabetes-mellitus-undergoing-percutaneous-coronary-intervention-with-drug-eluting-stent
#5
Jian-Long Wang, Zheng Qin, Zhi-Jian Wang, Dong-Mei Shi, Yu-Yang Liu, Ying-Xin Zhao, Li-Xia Yang, Wan-Jun Cheng, Yu-Jie Zhou
Background: Percutaneous coronary intervention (PCI) had become the major therapeutic procedure for coronary artery disease (CAD), but the high rate of in-stent restenosis (ISR) still remained an unsolved clinical problem in clinical practice. Increasing evidences suggested that diabetes mellitus (DM) was a major risk factor for ISR, but the risk predictors of ISR in CAD patients with DM had not been well characterized. The aim of this study was to investigate the clinical and angiographic characteristic predictors significantly associated with the occurrence of ISR in diabetic patients following coronary stenting with drug-eluting stent (DES)...
February 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29661331/geriatric-dysphagia
#6
REVIEW
Ozlem E Tulunay-Ugur, David Eibling
Geriatric dysphagia is an unrecognized and underdiagnosed problem with significant morbidity and potential mortality. It requires diligence by the clinician and a team approach for successful management. Careful history-taking is the key in the treatment of these patients and determines further workup, as well as treatment.
May 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29661245/socioeconomic-health-inequality-in-malaria-indicators-in-rural-western-kenya-evidence-from-a-household-malaria-survey-on-burden-and-care-seeking-behaviour
#7
Vincent Were, Ann M Buff, Meghna Desai, Simon Kariuki, Aaron Samuels, Feiko O Ter Kuile, Penelope A Phillips-Howard, S Patrick Kachur, Louis Niessen
BACKGROUND: Health inequality is a recognized barrier to achieving health-related development goals. Health-equality data are essential for evidence-based planning and assessing the effectiveness of initiatives to promote equity. Such data have been captured but have not always been analysed or used to manage programming. Health data were examined for microeconomic differences in malaria indices and associated malaria control initiatives in western Kenya. METHODS: Data was analysed from a malaria cross-sectional survey conducted in July 2012 among 2719 people in 1063 households in Siaya County, Kenya...
April 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29661163/characteristics-of-keratoconic-patients-at-two-main-eye-centres-in-palestine-a-cross-sectional-study
#8
Yousef Shanti, Ithar Beshtawi, Sa'ed H Zyoud, Ahlam Abu-Samra, Areen Abu-Qamar, Reem Barakat, Reham Shehada
BACKGROUND: Keratoconus (KC) is a multifactorial, degenerative ectatic condition of the cornea. It usually manifests during late adolescence or the early twenties. A painless disease, KC may end with severe visual loss. The prevalence of KC in middle-eastern countries is much higher than in other regions of the world. This may be due to genetic and environmental risk factors and consanguinity. The goal of this study is to explore the demographic profile of Palestinian keratoconic patients...
April 16, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29660317/history-of-cryobiology-with-special-emphasis-in-evolution-of-mouse-sperm-cryopreservation
#9
REVIEW
Jorge M Sztein, Toru Takeo, Naomi Nakagata
Confucius said study the past if you would define the future and a popular statement says that history depends on who writes it. To talk about history it is necessary to find and define a milestone where to start the narration. The intention of this quick review is to take the reader through moments and selected publications; part and pieces of memories showing how the concept of cryopreservation, specifically for mouse sperm, was conceived and sustained as we know it today. Beginning with the development of the microscope (1677) and continuing through the 17th century with the first documented observation by L...
April 13, 2018: Cryobiology
https://www.readbyqxmd.com/read/29660151/hangover-in-post-college-aged-drinkers-psychometric-properties-of-the-hangover-symptom-scale-hss-and-the-hangover-symptom-scale-short-form-hss-5
#10
Jesus Chavarria, Sandra Y Rueger, Andrea C King
BACKGROUND: Alcohol hangovers have been found to be a common and costly consequence of alcohol misuse. However, there is only limited psychometric support for instruments to accurately measure hangovers beyond the college-age years. This study investigated the psychometric properties of the Hangover Symptom Scale (HSS) and the Hangover Symptom Scale-Short Form (HSS-5) including the internal consistency, convergent and discriminant validity, construct validity, and the measurement invariance of these scales between light and heavy drinkers, individuals with a positive and negative family history of alcohol use disorder (AUD), and men and women in a post-college-aged sample...
April 16, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29658513/b-2-adrenergic-receptor-gene-polymorphism-effect-on-childhood-asthma-severity-and-response-to-treatment
#11
Ashgan Abdallah Alghobashy, Sahar A Elsharawy, Usama M Alkholy, Nermin Abdalmonem, Mohamed Ali Abdou, Maha A A Basset, Heba Fouad Pasha
BackgroundAlterations of B2 adrenergic receptor (β2 AR) can modulate the severity of asthma and the response to treatment. Therefore, we aimed to evaluate β2 AR gene polymorphism at codons 16 and 27 and their effect on asthma severity and response to treatment in asthmatic children.MethodsCase-control study was conducted on 156 children; 104 of them had bronchial asthma and 52 were healthy children (control group). Subjects of the study underwent history taking, clinical examination, pulmonary function tests, serum IgE level assessment, and identification of β2 AR-16 A46G and β2 AR-27 C79G polymorphism using PCR-Restriction Fragment length polymorphisms (RFLP) test...
March 2018: Pediatric Research
https://www.readbyqxmd.com/read/29657905/knowledge-of-postgraduate-medical-trainees-regarding-epidemiology
#12
Shoaib Shafi, Tayyaba Faisal, Sajida Naseem, Sajida Javed, Haider Ghazanfar
Introduction An understanding of epidemiology is fundamental for designing research and understanding evidence-based medicine (EBM). The purpose of our study was to determine the knowledge of epidemiology among postgraduate medical trainees. Methods We carried out a cross-sectional study from January 2017 to June 2017 at the Regional Centre Islamabad, College of Physicians and Surgeons Pakistan. About 204 postgraduate medical trainee were enrolled in the study after taking written consent. All of the participants were working as a postgraduate medical trainee in different hospitals of Rawalpindi and Islamabad...
February 8, 2018: Curēus
https://www.readbyqxmd.com/read/29656044/state-of-the-art-knowledge-in-adrenocortical-and-behavioral-responses-to-environmental-challenges-in-a-threatened-south-american-ratite-implications-to-in-situ-and-ex-situ-conservation
#13
REVIEW
Navarro Joaquín Luis, Alvina Lèche, Natalia S Della Costa, Marilina Vera Cortez, Raúl H Marin, Mónica B Martella
The Greater Rhea (Rhea americana) is an endemic ratite to South America, whose wild populations have undergone a remarkable decrease due to habitat degradation and fragmentation by the expansion of the agricultural frontier, poaching and predation by dogs. Anthropogenic perturbations in wild environments, as well as the management in captivity, can generate different stress responses in this species, thus, the monitoring of adrenocortical and behavioral activities are considered primary assessment tools with both conservation and welfare implications...
April 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29652149/zero-dimensional-cesium-lead-halides-history-properties-and-challenges
#14
Quinten Adriaan Akkerman, Ahmed L Abdelhady, Liberato Manna
Over the past decade, lead halide perovskites (LHPs) have emerged as new promising materials in the fields of photovoltaics and light emission due to their facile syntheses and exciting optical properties. The enthusiasm generated by LHPs has inspired research in perovskite-related materials, including so-called 'zero-dimensional cesium lead halides' which will be the focus of this perspective. The structure of these materials is formed of disconnected lead halide octahedra that are stabilized by cesium ions...
April 13, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29650854/-a-case-of-hyperammonemia-induced-by-chemotherapy-with-5-fluorouracil-for-metastatic-colon-cancer
#15
Shinji Tokuyama, Mutsumi Fukunaga, Ken Konishi, Shoko Honda, Ryohei Yukimoto, Aoi Okamoto, Akina Saito, Kazuyuki Okada, Hideo Ota, Shigekazu Yokoyama, Hirofumi Miki, Kenji Kobayashi
Systemic chemotherapy based on 5-fluorouracil(5-FU)is a standard treatment for unresectable or recurrent colon cancers. Here, we report a case of hyperammonemia induced by chemotherapy using 5-FU for metastatic colon cancer. An 84-yearold male patient with past histories of liver cirrhosis related to hepatitis C virus and renal dysfunction underwent an operation for the rectosigmoid colon cancer 8 years ago. Three years after that operation, a local recurrence of the colon cancer was diagnosed, and chemotherapy using sLV5FU2 was initiated...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650740/managing-complexity-in-care-of-patients-with-intellectual-and-developmental-disabilities-natural-fit-for-the-family-physician-as-an-expert-generalist
#16
REVIEW
Elizabeth Grier, Dara Abells, Ian Casson, Meg Gemmill, Jessica Ladouceur, Amanda Lepp, Ullanda Niel, Samantha Sacks, Kyle Sue
OBJECTIVE: To delineate the factors inherent in caring for patients with intellectual and developmental disabilities (IDD) that lead to complexity and to provide perspectives and techniques mapped to the phases of the clinical encounter. SOURCES OF INFORMATION: The authors of the physical health section of the 2018 Canadian consensus guidelines on the primary care of adults with IDD consisted of family physicians, all of whom practise comprehensive family medicine with additional clinical experience in care of adults with IDD...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650067/diagnostic-errors-and-the-bedside-clinical-examination
#17
REVIEW
Bennett W Clark, Arsalan Derakhshan, Sanjay V Desai
Diagnostic errors are common in clinical practice and lead to adverse patient outcomes. Systematic reviews have shown that inadequate history taking and physical examination lead to a plurality, if not a majority, of diagnostic errors. Recent advances in cognitive science have also shown that unconscious biases likely contribute to many diagnostic errors. Research into diagnostic error has been hampered by methodologic inconsistency and a paucity of studies in real-world clinical settings. The best evidence indicates that educational interventions to reduce diagnostic error should give physicians feedback about clinical outcomes and enhance their ability to recognize signs and symptoms of specific diseases at the bedside...
May 2018: Medical Clinics of North America
https://www.readbyqxmd.com/read/29649615/fever-related-arrhythmic-events-in-the-multicenter-survey-on-arrhythmic-events-in-brugada-syndrome-sabrus
#18
Yoav Michowitz, Anat Milman, Georgia Sarquella-Brugada, Antoine Andorin, Jean Champagne, Pieter G Postema, Ruben Casado-Arroyo, Eran Leshem, Jimmy Jm Juang, Carla Giustetto, Jacob Tfelt-Hansen, Yanushi D Wijeyeratne, Christian Veltmann, Domenico Corrado, Sung-Hwan Kim, Pietro Delise, Shingo Maeda, Jean-Baptiste Gourraud, Frederic Sacher, Philippe Mabo, Yoshihide Takahashi, Tsukasa Kamakura, Takeshi Aiba, Giulio Conte, Aviram Hochstadt, Yuka Mizusawa, Michael Rahkovich, Elena Arbelo, Zhengrong Huang, Isabelle Denjoy, Carlo Napolitano, Ramon Brugada, Leonardo Calo, Silvia G Priori, Masahiko Takagi, Elijah R Behr, Fiorenzo Gaita, Gan-Xin Yan, Josep Brugada, Antoine Leenhardt, Arthur A M Wilde, Pedro Brugada, Kengo F Kusano, Kenzo Hirao, Gi-Byoung Nam, Vincent Probst, Bernard Belhassen
BACKGROUND: The literature on fever related arrhythmic events (AE) in Brugada syndrome (BrS) is currently limited to few case reports and small series. OBJECTIVE: The current study aims to describe the characteristics of fever-related AE in a large cohort of BrS patients. METHODS: SABRUS is a multicenter study on 678 BrS patients with first AE documented at time of aborted cardiac arrest (ACA) (n=426) or after prophylactic ICD implantation (n=252)...
April 9, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29648682/elderly-onset-varicella-pneumonia-in-a-patient-with-rheumatoid-arthritis-taking-tofacitinib
#19
Nobuya Abe, Takashi Kudo, Satoshi Jodo
A 68-year-old woman with rheumatoid arthritis, who was treated with tofacitinib, a type of Janus kinase (JAK) inhibitor, was admitted for dyspnea and generalized purpuric vesicular rash, following 3 days of fever and malaise. She developed hypoxia from respiratory insufficiency. On physical examination, the systemic eruptions had an erythematous base and were present in various stages, from maculopapular to vesicular and pustular, with crusting (left). Chest radiograph demonstrated diffuse infiltrates with reticular and nodular lesions in the bilateral lung fields (right)...
April 12, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29644298/use-of-idarucizumab-for-dabigatran-reversal-emergency-department-experience-in-two-cases-with-subdural-haematoma
#20
Gail Edwards, Cristina Roman, Rondhir Jithoo, Biswadev Mitra
Introduction: Idarucizumab is the first effective humanized monoclonal antibody fragment developed specifically as a reversal agent for dabigatran, a Direct Oral Anticoagulant. Despite recent trials demonstrating reversal of clinically relevant bleeding, there is a paucity of data on use outside the trial setting. This manuscript describes the use of Idarucizumab to reverse dabigatran in two patients presenting to the emergency department of a major tertiary hospital with acute traumatic subdural haematomas (SDH)...
February 2018: Trauma Case Reports
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