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atrial fibrillation recurrence risk factors

Gary J Doherty, Dochka Davidson, Han H Wong, Helen M Hatcher
Trabectedin is used routinely in the palliative management of patients with advanced soft tissue sarcoma. It is not generally considered to be cardiotoxic, and there is no specific caution for its use in patients with a history of cardiac disease or risk factors. Here, we report six cases from a single academic centre where life-threatening cardiotoxicity occurred acutely during treatment with trabectedin. These patients had a median age of 72.5 years (range: 68-81) at presentation with cardiotoxicity, significantly higher than the median ages of patients treated with trabectedin in clinical trials...
January 2019: Anti-cancer Drugs
Tess Fitzpatrick, Sophia Gocan, Chu Q Wang, Candyce Hamel, Aline Bourgoin, Dar Dowlatshahi, Grant Stotts, Michel Shamy
BACKGROUND: Identifying and treating patients with transient ischemic attack is an effective means of preventing stroke. However, making this diagnosis can be challenging, and over a third of patients referred to stroke prevention clinic are ultimately found to have alternate diagnoses. AIMS: We performed a systematic review to determine how neurologists diagnose transient ischemic attack. SUMMARY OF REVIEW: A systematic literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using MEDLINE, Embase, and the Cochrane Library databases...
December 3, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
Yun Gi Kim, Jaemin Shim, Suk-Kyu Oh, Kwang-No Lee, Jong-Il Choi, Young-Hoon Kim
BACKGROUND: Electrical isolation of the left atrial appendage (LAA) is associated with a lower rate of atrial fibrillation (AF) recurrence in patients undergoing radiofrequency catheter ablation. However, LAA isolation can significantly impair LAA contractility. OBJECTIVE: This study was performed to evaluate whether electrical isolation of the LAA is associated with an increased risk of ischemic stroke or transient ischemic attack (TIA). METHODS: Consecutive patients with AF undergoing radiofrequency catheter ablation at Korea University Medical Center Anam Hospital were analyzed...
December 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Luke Lam, Hyeong Jun Ahn, Kazue Okajima, Katie Schoenman, Todd B Seto, Ralph V Shohet, Jill Miyamura, Tetine L Sentell, Kazuma Nakagawa
BACKGROUND: It has been reported that women have higher 30-day readmission rates than men after acute coronary syndrome (ACS). However, readmission after percutaneous coronary intervention (PCI) for ACS is a distinct subset of patients in whom gender differences have not been adequately studied. METHODS: Hawaii statewide hospitalization data from 2010 to 2015 were assessed to compare gender differences in 30-day readmission rates among patients hospitalized with ACS who underwent PCI during the index hospitalization...
October 25, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
Benjamin De Becker, Van De Borne Philippe
Atrial fibrillation (AF) and hypertension (HT) are expected to rapidly rise worldwide in the next few years. Important improvements in AF therapy are hampered by pro-arrhythmic and bleeding risks of current medications. Prevention of AF is an important matter as it will not only prevent the disease but also medications side effects, and it is likely to be cost effective. HT is a major contributor to AF. As a modifiable risk factor, its treatment might reduce new-onset AF, and recurrent AF after cardioversion or ablation as well...
November 26, 2018: Current Pharmaceutical Design
Fumi Yamagami, Kazuko Tajiri, Kosuke Doki, Masayuki Hattori, Junya Honda, Satoshi Aita, Tomohiko Harunari, Hiro Yamasaki, Nobuyuki Murakoshi, Yukio Sekiguchi, Masato Homma, Naohiko Takahashi, Kazutaka Aonuma, Akihiko Nogami, Masaki Ieda
Renal dysfunction results in the accumulation of various uremic toxins, including indoxyl sulphate (IS), and is a major risk factor for atrial fibrillation (AF). Experimental studies have demonstrated that IS exacerbates atrial remodelling via oxidative stress, inflammation, and fibrosis. However, its clinical impact on AF-promoting cardiac remodelling has not been described. Therefore, the purpose of this study was to clarify the relationship between basal IS levels and the 1-year outcomes after catheter ablation for the treatment of AF...
November 22, 2018: Scientific Reports
Matthew Lewis, William Whang, Angelo Biviano, Kathleen Hickey, Hasan Garan, Marlon Rosenbaum
BACKGROUND: Catheter ablation is commonly performed to treat atrial arrhythmias in adult congenital heart disease (ACHD). Despite the frequency of ablations in the ACHD population, predictors of recurrence remain poorly defined. OBJECTIVE: We sought to determine predictors of arrhythmia recurrence in ACHD patients following catheter ablation for atrial arrhythmias. METHODS: We performed a retrospective study of all catheter ablations for atrial arrhythmias performed in ACHD patients between January 12, 2005 and February 11, 2015 at our institution...
November 19, 2018: Congenital Heart Disease
Illa Mihejeva, Anita Vētra, Guna Bērziņa
AIM: The aim of this study was to evaluate how pre-stroke risk factors, neurological symptoms, and the level of disability shortly after stroke are associated with poststroke mortality during a 7-year period after stroke, for persons treated in a stroke unit. METHODS: The data of 231 patients were included in the study. Patients who were treated in the stroke unit at the Riga East University Hospital between February 1, 2009, and July 20, 2009, were included in this study...
November 12, 2018: Brain and Behavior
Julien Feghaly, Patrick Zakka, Barry London, Calum A MacRae, Marwan M Refaat
Background Atrial fibrillation ( AF ) is a common arrhythmia seen in clinical practice. Occasionally, no common risk factors are present in patients with this arrhythmia. This suggests the potential underlying role of genetic factors associated with predisposition to developing AF . Methods and Results We conducted a comprehensive review of the literature through large online libraries, including PubMed. Many different potassium and sodium channel mutations have been discussed in their relation to AF . There have also been non-ion channel mutations that have been linked to AF ...
October 16, 2018: Journal of the American Heart Association
Lotte Kaasenbrood, Deepak L Bhatt, Jannick A N Dorresteijn, Peter W F Wilson, Ralph B D'Agostino, Joseph M Massaro, Yolanda van der Graaf, Maarten J M Cramer, L Jaap Kappelle, Gert J de Borst, Ph Gabriel Steg, Frank L J Visseren
Background In patients with vascular disease, risk models may support decision making on novel risk reducing interventions, such as proprotein convertase subtilisin/kexin type 9 inhibitors or anti-inflammatory agents. We developed and validated an innovative model to estimate life expectancy without recurrent cardiovascular events for individuals with coronary, cerebrovascular, and/or peripheral artery disease that enables estimation of preventive treatment effect in lifetime gained. Methods and Results Study participants originated from prospective cohort studies: the SMART (Secondary Manifestations of Arterial Disease) cohort and REACH (Reduction of Atherothrombosis for Continued Health) cohorts of 14 259 ( REACH Western Europe), 19 170 ( REACH North America) and 6959 ( SMART , The Netherlands) patients with cardiovascular disease...
August 21, 2018: Journal of the American Heart Association
Christina L Fanola, Christian T Ruff, Sabina A Murphy, James Jin, Anil Duggal, Noe A Babilonia, Piyamitr Sritara, Michele F Mercuri, Pieter W Kamphuisen, Elliott M Antman, Eugene Braunwald, Robert P Giugliano
Background Anticoagulation in patients with malignancy and atrial fibrillation is challenging because of enhanced risks for thrombosis and bleeding and the frequent need for invasive procedures. Data on direct oral antagonists in such patients are sparse. Methods and Results The ENGAGE AF - TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction Study 48) trial randomized 21 105 patients with atrial fibrillation to edoxaban or warfarin...
August 21, 2018: Journal of the American Heart Association
Shengbang Zheng, Baodong Yao
Risk factors for first-ever stroke have been studied extensively, while those for recurrent stroke are not accurately understood. To provide the adequate secondary prevention for the patients, it is necessary to reveal the risk factors that dominate recurrent stroke. Multiple databases were adopted to search for the relevant studies and full-text articles involving in the risk factors for stroke recurrence were reviewed. Meta-analyses were performed with Review Manager 5.0 to estimate the impact of risk factors included, and forest plots, quality analysis and bias analysis for the articles included were also conducted...
October 16, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Chan Joo Lee, Tae-Hoon Kim, Sungha Park, Hui-Nam Pak
Background: Obstructive sleep apnea (OSA) is a well-known predictor of atrial fibrillation (AF). However, OSA usually accompanies other risk factors of AF. We tried to investigate whether OSA is related to AF recurrence after catheter ablation. Methods: A total of 378 patients (mean age 59.9 ± 10.7 years, 72.5$ male) who underwent catheter ablation of AF were enrolled and underwent overnight ambulatory polysomnography before the ablation procedure. These patients were examined once every 3 months at the outpatient clinic to determine AF recurrence...
July 2018: Pulse (Basel, Switzerland)
Ya Zhu Wang, Jinqi Fan, Bin Zhong, Qiang Xu
Apelin, the ligand for the APJ receptor, is involved in the pathogenesis of atrial fibrillation (AF). However, whether serum apelin can predict the recurrence of AF after pulmonary vein isolation (PVI) has not been determined.A prospective cohort study was performed in patients with AF (but without structural heart disease) who were undergoing first-time PVI. Serum apelin-12 was measured by enzyme-linked immunosorbent assay. Echocardiographic examination was performed at baseline, 3 months, and 6 months after PVI...
September 2018: Medicine (Baltimore)
Bibijana Rostohar Bijelić, Marta Petek, Mira Kadojić, Nikola Bijelić, Dragutin Kadojić
The aim of this study was to determine the distribution of risk factors according to age, gender, subtypes and recurrence of stroke in eastern Croatia. The study included 250 acute stroke patients admitted to University Department of Neurology, Osijek University Hospital Centre in 2011. Patients were grouped according to age, gender, subtypes and recurrence of stroke. The study showed significant differences in the distribution of cigarette smoking, diabetes, cardiomyopathy and hyperuricemia according to patient age...
March 2018: Acta Clinica Croatica
Agnieszka Zienciuk-Krajka, Maciej Sterliński, Artur Filipecki, Radosław Owczuk, Jacek Bednarek, Maciej Kempa, Sławomir Sielski, Marcin Dziduszko, Przemysław Mitkowski, Jarosław Kaźmierczak, Jacek Kuśnierz, Dariusz Michałkiewicz, Sebastian M Stec, Marcin Gułaj, Ryszard Majcherek, Andrzej Lubiński, Grzegorz Raczak
BACKGROUND: Implantable cardioverter-defibrillator (ICD) therapy has been proven effective in prevention of sudden cardiac death (SCD), but data on outcomes for ICD therapy in the young and otherwise healthy Long QT Syndrome (LQTS) population are limited. AIMS: To collect data on appropriate and inappropriate ICD discharges, risk factors, and ICD-related complications. METHODS: All LQTS patients implanted with an ICD in 14 centres were investigated, and demographical, clinical and data on ICD therapy were collected...
September 25, 2018: Kardiologia Polska
Minetaka Maeda, Kageyuki Oba, Satoshi Yamaguchi, Osamu Arasaki, Masataka Sata, Hiroaki Masuzaki, Michio Shimabukuro
Although increasing evidence suggests that epicardial adipose tissue volume (EATV) is associated with post-ablation atrial fibrillation (AF), ranges of EATV predictive of post-ablation recurrence of AF remain unclear. In this study, we evaluated: (1) relationships between EATV and characteristics of AF, (2) impact of EATV on recurrent AF after radiofrequency ablation; , and (3) cut-off point for recurrent AF using a receiver operating characteristic curve. In 218 consecutive symptomatic patients undergoing who underwent ablation for AF (143 paroxysmal AF; 78 persistent AF), the EATV index (EATVI: EATV/body surface area, mL/m2 ) was measured using 320-row multidetector computed tomography...
August 21, 2018: American Journal of Cardiology
Avi Sabbag, Xiaoxi Yao, Konstantinos C Siontis, Peter A Noseworthy
The burden of atrial fibrillation (AF) is projected to increase substantially over the next decade in parallel with the aging of the population. The increasing age, level of comorbidity, and polypharmacy will complicate the treatment of older adults with AF. For instance, advanced age and chronic kidney disease have been shown to increase the risk of both thromboembolism and bleeding in patients with AF. Frailty, recurrent falls and polypharmacy, while very common among elderly patients with AF, are often overlooked in the clinical decision making despite their significant interaction with oral anticoagulant (OAC) and profound impact on the patient's clinical outcomes...
October 2018: Korean Circulation Journal
Antonio Gómez-Outes, Mª Luisa Suárez-Gea, Jose Manuel García-Pinilla
Stroke is a significant source of morbidity and mortality in developed countries. Cardioembolic strokes represent approximately 15-30% of all ischemic strokes. They are frequently related to atrial fibrillation (AF) and have a worse prognosis and high recurrence rates when compared to other causes (e.g. atherosclerosis). Areas covered: This review includes a summary of general and specific scores to assess cardiovascular and stroke risks, with a focus on specific scores available in AF. Recommendations for antithrombotic therapy are also reviewed...
September 2018: Expert Opinion on Pharmacotherapy
Shunsuke Tomomori, Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Chikaaki Motoda, Hiroya Matsumura, Michitaka Amioka, Naoya Hironobe, Yousaku Ookubo, Shou Okamura, Hiroshi Kawazoe, Kazuaki Chayama, Yasuki Kihara
INTRODUCTION: The single nucleotide polymorphism (SNP) rs2106261 in the transcription factor gene ZFHX3 (16q22), a major regulator of inflammation, has been reported linking to atrial fibrillation (AF) by genome-wide association studies. Inflammation is known to be a strong predictor of atrial fibrillation recurrence after ablation, so we examined the association of the ZFHX3 SNP rs2106261 to inflammation marker expression and recurrence after AF ablation. METHODS: We genotyped ZFHX3 SNP rs2106261 and compared the minor (T) allele frequency between 362 paroxysmal AF (PAF) patients underwent pulmonary vein isolation (PVI) and 627 non-AF controls...
2018: PloS One
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