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https://www.readbyqxmd.com/read/30263873/human-adipose-derived-stem-cell-conditioned-media-and-exosomes-containing-malat1-promote-human-dermal-fibroblast-migration-and-ischemic-wound-healing
#1
Denise R Cooper, Chunyan Wang, Rehka Patel, Andrea Trujillo, Niketa A Patel, Jamie Prather, Lisa J Gould, Mack H Wu
Objective: Chronically ill patients heal recalcitrant ulcerative wounds more slowly. Human adipose-derived stem cells (hADSCs) play an important role in tissue regeneration and exosomes secreted by hADSC contribute to their paracrine signaling. In addition to cytokines, lipids and growth factors, hADSC secrete mRNA, miRNA, and long noncoding (lnc) RNA into exosomes. In this study we examined the role of lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), an abundant lncRNA in exosomes from conditioned media (CM), on cell migration and ischemic wound healing...
September 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/30246884/sulodexide-inhibits-angiogenesis-via-decreasing-dll4-and-notch1-expression-in-mouse-proepicardial-explant-cultures
#2
Justyna Niderla-Bielińska, Krzysztof Bartkowiak, Bogdan Ciszek, Ewa Jankowska-Steifer, Alicja Krejner, Anna Ratajska
Sulodexide (SDX) is a mixed drug containing low-molecular weight heparin sulphate and dermatan sulphate. It exerts mild anticoagulant action but can also affect leucocytes, macrophages, and cell-cell adhesion and may interact with growth factors although its direct influence on endothelial cells is not well described. Clinically SDX is used for the treatment of cardiovascular diseases, where it exerts anti-inflammatory and endothelial protective effects. The aim of this study was to determine the influence of SDX on tubule formation and angiogenesis-related proteins' mRNA expression in endothelial cell line C166 and mouse proepicardial explants...
September 24, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/30219518/endothelium-specific-cyp2j2-overexpression-improves-cardiac-dysfunction-by-promoting-angiogenesis-via-jagged1-notch1-signaling
#3
REVIEW
Qinshuo Zhao, Jingqiu Huang, Dong Wang, Liang Chen, Dating Sun, Chunxia Zhao
BACKGROUND: Myocardial infarction (MI) contributes to the development of cardiac remodeling and heart failure. Insufficient post-MI myocardial angiogenesis has been identified as a non-negligible event which precipitates heart failure progression. Previous studies reported that cytochrome P450 epoxygenase and its metabolites exerted beneficial effects on cardiovascular diseases. However, the role of cytochrome P450 2J2 (CYP2J2) in post-MI heart failure is incompletely understood. METHODS AND RESULTS: First, western blot and real-time PCR analyses showed that CYP2J2 expression increased clearly in patients with acute MI and old MI, compared to control...
September 13, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/30197125/1-methoxycarbony-%C3%AE-carboline-from-picrasma-quassioides-exerts-anti-angiogenic-properties-in-huvecs-in-vitro-and-zebrafish-embryos-in-vivo
#4
Qing-Hua Lin, Wei Qu, Jian Xu, Feng Feng, Ming-Fang He
Angiogenesis is a crucial process in the development of inflammatory diseases, including cancer, psoriasis and rheumatoid arthritis. Recently, several alkaloids from Picrasma quassioides had been screened for angiogenic activity in the zebrafish model, and the results indicated that 1-methoxycarbony-β-carboline (MCC) could effectively inhibit blood vessel formation. In this study, we further confirmed that MCC can inhibit, in a concentration-dependent manner, the viability, migration, invasion, and tube formation of human umbilical vein endothelial cells (HUVECs) in vitro, as well as the regenerative vascular outgrowth of zebrafish caudal fin in vivo...
August 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30196288/discovery-and-characterization-of-a-high-affinity-small-peptide-ligand-h1-targeting-fgfr2iiic-for-skin-wound-healing
#5
Ying Zhao, Qiang Wang, Yuan Jin, Yadan Li, Changjun Nie, Peipei Huang, Zhixin Li, Bihui Zhang, Zijian Su, An Hong, Xiaojia Chen
BACKGROUND/AIMS: How to aid recovery from severe skin injuries, such as burns, chronic or radiation ulcers, and trauma, is a critical clinical problem. Current treatment methods remain limited, and the discovery of ideal wound-healing therapeutics has been a focus of research. Functional recombinant proteins such as basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) have been developed for skin repair, however, some disadvantages in their use remain. This study reports the discovery of a novel small peptide targeting fibroblast growth factor receptor 2 IIIc (FGFR2IIIc) as a potential candidate for skin wound healing...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30160040/collagen-heparin-bi-affinity-multilayer-modified-collagen-scaffolds-for-controlled-bfgf-release-to-improve-angiogenesis-in-vivo
#6
Wangping Hao, Jie Han, Yun Chu, Lei Huang, Yan Zhuang, Jie Sun, Xiaoran Li, Yannan Zhao, Yanyan Chen, Jianwu Dai
Basic fibroblast growth factor (bFGF) is an important protein for wound healing and angiogenesis in tissue engineering, but the lack of a viable delivery system hampers its clinical application. This study aims to maintain the long-term controlled release of bFGF by utilizing a collagen/heparin bi-affinity multilayer delivery system (CHBMDS), which is fabricated by the alternate deposition of negatively charged heparin, positively charged collagen, and CBD-bFGF (a collagen-binding domain [CBD] was fused into the native bFGF) via specific or electrostatic interaction...
August 29, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/30108995/antitumor-effects-of-melanin-from-lachnum-ym226-and-its-derivative-in-h22-tumor-bearing-mice
#7
Fang Shi, Jinglei Li, Ziyang Ye, Liuqing Yang, Tingting Chen, Xue Chen, Ming Ye
In the present study, we investigated the anti-tumor activities of the intracellular homogeneous melanin (LM) of Lachnum YM226 and its derivative (ALM) on liver cancer using murine H22 hepatocarcinoma model. The results showed that LM and ALM (50 and 200 mg kg-1 ) could effectively inhibit tumor growth of H22 tumour-bearing mice. The body weight, liver, spleen and thymus indices also improved in the LM and ALM treated groups. Moreover, the levels of alanine aminotransferase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), creatinine (CRE), blood urea nitrogen (BUN) and uric acid (UA) were lowered...
June 1, 2018: MedChemComm
https://www.readbyqxmd.com/read/30083950/pro-inflammatory-cytokines-and-growth-factors-in-human-milk-an-exploratory-analysis-of-racial-differences-to-inform-breast-cancer-etiology
#8
Jeanne Murphy, Ruth M Pfeiffer, Brittny C Davis Lynn, Ana I Caballero, Eva P Browne, Elizabeth C Punska, Hannah P Yang, Roni T Falk, Douglas L Anderton, Gretchen L Gierach, Kathleen F Arcaro, Mark E Sherman
BACKGROUND: Analysis of cytokines and growth factors in human milk offers a noninvasive approach for studying the microenvironment of the postpartum breast, which may better reflect tissue levels than testing blood samples. Given that Black women have a higher incidence of early-onset breast cancers than White women, we hypothesized that milk of the former contains higher levels of pro-inflammatory cytokines, adipokines, and growth factors. METHODS: Participants included 130 Black and 162 White women without a history of a breast biopsy who completed a health assessment questionnaire and donated milk for research...
August 6, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/30046341/xijiao-dihuang-decoction-alleviates-ischemic-brain-injury-in-mcao-rats-by-regulating-inflammation-neurogenesis-and-angiogenesis
#9
Xiaojun Fei, Xu Zhang, Qi Wang, Jingbo Li, Hao Shen, Xuanye Wang, Hongquan Liu, Weiwei Tao
Ischemic stroke is an increasingly important public health problem, and no effective treatments are approved. Xijiao Dihuang Decoction (XDD), a famous herbal formula for treating hemorrhagic fever syndromes, has been shown to exert powerful neuroprotective property. The aim of this study was to identify the chemical constituents in XDD, observe the neuroprotective effect of XDD against acute ischemic stroke, and explore the specific mechanisms by which these effects were mediated. With UHPLC-Q/TOF-MS, 47 components in XDD were detected and 25 of them were identified...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30031765/effect-of-local-application-of-transcutaneous-carbon-dioxide-on-survival-of-random-pattern-skin-flaps
#10
Izumi Saito, Takumi Hasegawa, Takeshi Ueha, Daisuke Takeda, Eiji Iwata, Satomi Arimoto, Akiko Sakakibara, Masaya Akashi, Shunsuke Sakakibara, Yoshitada Sakai, Hiroto Terashi, Takahide Komori
INTRODUCTION: Skin flap procedures are widely used to reconstruct skin and soft tissue defects. Skin flap necrosis is a serious postoperative complication. Many researchers have introduced pharmacological agents to improve flap ischemia in experimental studies. However, outcomes of these studies remain controversial. We previously demonstrated that transcutaneous CO2 application improves hypoxia in fracture repair. In this study, we hypothesized that improving hypoxia by transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis...
June 28, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/30026681/ghrelin-ameliorates-traumatic-brain-injury-by-down-regulating-bfgf-and-fgf-bp
#11
Xuefei Shao, Qianxin Hu, Sansong Chen, Qifu Wang, Pengcheng Xu, Xiaochun Jiang
Traumatic brain injury (TBI) is a primary cause of disability and mortality. Ghrelin, a gastrointestinal hormone, has been found to have protective effects for the brain, but the molecular mechanism of these neuroprotective effects of ghrelin remains unclear. In this study, an electronic cortical contusion impactor was used to establish a rat TBI model and we investigated the effect of ghrelin on brain repair by neurological severity score and histological examination. An antibody array was employed to uncover the molecular mechanism of ghrelin's neuroprotective effects by determining the alterations of multiple proteins in the brain cortex...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29998469/effect-of-sustained-release-of-basic-fibroblast-growth-factor-using-biodegradable-gelatin-hydrogels-on-frozen-thawed-human-ovarian-tissue-in-a-xenograft-model
#12
Ayaka Tanaka, Hitomi Nakamura, Yasuhiko Tabata, Yuka Fujimori, Keiichi Kumasawa, Tadashi Kimura
AIM: Ovarian tissue cryopreservation before cancer treatment is the only option to preserve fertility under some circumstances. However, tissue ischemia after transplantation while awaiting angiogenesis induces dysfunctional folliculogenesis and reduces ovarian reserve and is one of the disadvantages of frozen-thawed ovarian tissue transplantation. Basic fibroblast growth factor (bFGF) is a major regulator of angiogenesis. However, bFGF rapidly loses biological activity when its free form is injected in vivo...
October 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29983872/silencing-nik-potentiates-anti-vegf-therapy-in-a-novel-3d-model-of-colorectal-cancer-angiogenesis
#13
Chrissta X Maracle, Kim C M Jeucken, Boy Helder, Thomas M van Gulik, Anne Steins, Hanneke W M van Laarhoven, Sander W Tas
Angiogenesis is essential for colorectal cancer (CRC) progression, as demonstrated by the beneficial clinical effects of therapeutics inhibiting VEGF signaling. However, alternative mechanisms of neovascularization can develop, resulting in treatment failure. Previously we demonstrated NF-κB-inducing kinase (NIK) contributes to pathological angiogenesis. Here, we investigate NIK as a therapeutic target in endothelial cells (EC) in CRC. To determine NIK expression levels in CRC tissues, we immunostained both primary colorectal tumors and tumors metastasized to the liver...
June 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29980670/lactate-potentiates-angiogenesis-and-neurogenesis-in-experimental-intracerebral-hemorrhage
#14
Jing Zhou, Tao Liu, Hao Guo, Hanjin Cui, Pengfei Li, Dandan Feng, En Hu, Qing Huang, Ali Yang, Jun Zhou, Jiekun Luo, Tao Tang, Yang Wang
Lactate accumulation has been observed in the brain with intracerebral hemorrhage (ICH). However, the outcome of lactate accumulation has not been well characterized. Here, we report that lactate accumulation contributes to angiogenesis and neurogenesis in ICH. In the first set of the experiment,  a rat model of ICH was induced by injecting collagenase into the brain. The effects of lactate accumulation on the neurological function, apoptosis, and numbers of newborn endothelial cells and neurons, as well as the proliferation-associated signaling pathway, were evaluated in the rat brain...
July 6, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29948798/kefir-accelerates-burn-wound-healing-through-inducing-fibroblast-cell-migration-in-vitro-and-modulating-the-expression-of-il-1%C3%A3-tgf-%C3%A3-1-and-bfgf-genes-in-vivo
#15
Ahmad Oryan, Esmat Alemzadeh, Mohammad Hadi Eskandari
Kefir is a natural probiotic compound with a long history of health benefits which can improve wound healing. This study investigated the regeneration potential of kefir in vitro scratch assay and in vivo burn wound in rat model. Cytotoxicity of different concentrations of kefir was evaluated by colorimetric methylthiazoltetrazolium assay. A scratch wound experiment was performed to investigate the ability of kefir in reducing the gap of wounds in a dose-dependent manner, in vitro. The standardized kefir was incorporated into silver sulfadiazine (SSD) and applied on burn wounds in vivo, and was compared with the SSD and negative control groups after 7, 14, and 28 days of treatment...
June 8, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29896285/construction-of-a-human-monoclonal-antibody-against-bfgf-for-suppression-of-nsclc
#16
Sheng Wang, Yiyang Qin, Zhongmin Wang, Junjian Xiang, Yu Zhang, Meng Xu, Baiyong Li, Yu Xia, Peng Zhang, Hong Wang
Compelling evidence implicates that overexpression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor 1 (FGFR1) in non-small cell lung cancer (NSCLC) drives tumor progression, can serve as prognostic biomarkers or therapeutic targets for NSCLC patients. But at present, we still lack of effective drugs for bFGF. The preparation of monoclonal antibodies against bFGF or to understand its mechanism of action is urgently need. Previously, we used hybridoma technology to produce a murine anti-bFGF monoclonal antibody (E12)...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29874597/a-targeted-nanoplatform-co-delivering-chemotherapeutic-and-antiangiogenic-drugs-as-a-tool-to-reverse-multidrug-resistance-in-breast-cancer
#17
Fengchun Tian, Fatima Zohra Dahmani, Jianan Qiao, Jiang Ni, Hui Xiong, Tengfei Liu, Jianping Zhou, Jing Yao
Several obstacles are currently impeding the successful treatment of breast cancer, namely impaired drug accumulation into the tumor site, toxicity to normal cells and narrow therapeutic index of chemotherapy, multidrug resistance (MDR) and the metastatic spread of cancer cells through the blood and lymphatic vessels. In this regard, we designed a novel multifunctional nano-sized drug delivery system based on LyP-1 peptide-modified low-molecular-weight heparin-quercetin conjugate (PLQ). This nanosystem was developed for targeted co-delivery of multiple anticancer drugs to p32-overexpressing tumor cells and peritumoral lymphatic vessels, using LyP-1 peptide as active targeting ligand, with the aim to achieve a targeted combinatorial chemo/angiostatic therapy and MDR reversal...
July 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29857900/functionalized-nanoliposomes-loaded-with-anti-survivin-and-anti-angiogenic-agents-to-enhance-the-activity-of-chemotherapy-against-melanoma-by-4-pronged-action
#18
Harshita Mishra, Pawan Kumar Mishra, Adam Ekielski, Zeenat Iqbal, Manu Jaggi, Sushama Talegaonkar
Melanoma is one of the most aggressive cancers which has very low response rate and survival rate. Melanoma cells are known to be inherently resistant to the chemotherapy which results in poor outcomes and even failure of the therapy. For this reason, a better understanding of underlying mechanism of melanoma pathogenesis and resistance is required, so that more efficient and novel therapeutic strategies can be developed. Survivin is a protein which is overexpressed in melanoma cells and is known to impart resistance to them against apoptosis...
July 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29807443/targeting-vegf-vegfrs-pathway-in-the-antiangiogenic-treatment-of-human-cancers-by-traditional-chinese-medicine
#19
Cheng Zhang, Ning Wang, Hor-Yue Tan, Wei Guo, Sha Li, Yibin Feng
Bearing in mind the doctrine of tumor angiogenesis hypothesized by Folkman several decades ago, the fundamental strategy for alleviating numerous cancer indications may be the strengthening application of notable antiangiogenic therapies to inhibit metastasis-related tumor growth. Under physiological conditions, vascular sprouting is a relatively infrequent event unless when specifically stimulated by pathogenic factors that contribute to the accumulation of angiogenic activators such as the vascular endothelial growth factor (VEGF) family and basic fibroblast growth factor (bFGF)...
September 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29790692/serum-concentrations-of-vegf-and-bfgf-in-the-course-of-propranolol-therapy-of-infantile-hemangioma-in-children-are-we-closer-to-understand-the-mechanism-of-action-of-propranolol-on-hemangiomas
#20
Lidia Babiak-Choroszczak, Kaja Giżewska-Kacprzak, Elżbieta Gawrych, Katarzyna Fischer, Anna Walecka, Lidia Puchalska-Niedbał, Justyna Rajewska-Majchrzak, Maciej Bagłaj
BACKGROUND: Propranolol has become the treatment of choice for infantile hemangiomas (IH). Neither the pathogenesis of IH nor the mechanism of action of propranolol on them are well understood. Possible explanations include the inhibition of angiogenesis by decreasing vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), induction of vascular endothelial cell apoptosis and vasoconstriction. OBJECTIVES: The aim of the study was to assess serum concentrations of VEGF and bFGF in the course of propranolol therapy of IH in children, and to assess their clinical implications...
May 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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