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Skeletal Muscle Regeneration

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https://www.readbyqxmd.com/read/30110909/decellularized-tissue-for-muscle-regeneration
#1
REVIEW
Anna Urciuolo, Paolo De Coppi
Several acquired or congenital pathological conditions can affect skeletal muscle leading to volumetric muscle loss (VML), i.e., an irreversible loss of muscle mass and function. Decellularized tissues are natural scaffolds derived from tissues or organs, in which the cellular and nuclear contents are eliminated, but the tridimensional (3D) structure and composition of the extracellular matrix (ECM) are preserved. Such scaffolds retain biological activity, are biocompatible and do not show immune rejection upon allogeneic or xenogeneic transplantation...
August 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30107211/muscle-fibrosis-in-the-soft-palate-delivery-of-cells-growth-factors-and-anti-fibrotics
#2
REVIEW
Johannes W Von den Hoff, Paola L Carvajal Monroy, Edwin M Ongkosuwito, Toin H van Kuppevelt, Willeke F Daamen
The healing of skeletal muscle injuries after major trauma or surgical reconstruction is often complicated by the development of fibrosis leading to impaired function. Research in the field of muscle regeneration is mainly focused on the restoration of muscle mass while far less attention is paid to the prevention of fibrosis. In this review, we take as an example the reconstruction of the muscles in the soft palate of cleft palate patients. After surgical closure of the soft palate, muscle function during speech is often impaired by a shortage of muscle tissue as well as the development of fibrosis...
August 11, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30106825/periostin-promotes-fibroblast-migration-and-inhibits-muscle-repair-after-skeletal-muscle-injury
#3
Masamitsu Hara, Kazuya Yokota, Takeyuki Saito, Kazu Kobayakawa, Ken Kijima, Shingo Yoshizaki, Ken Okazaki, Shigeo Yoshida, Yoshihiro Matsumoto, Katsumi Harimaya, Yasuharu Nakashima, Seiji Okada
BACKGROUND: Skeletal muscle injury (SMI) can cause physical disability due to insufficient recovery of the muscle. The development of muscle fibrosis after SMI has been widely regarded as a principal cause of this failure to recover. Periostin (Postn) exacerbates tissue fibrosis in various organs. We investigated whether Postn is involved in the pathophysiology after SMI. METHODS: Partial laceration injuries of the gastrocnemius were created in wild-type (WT) and Postn knockout (Postn) mice...
August 15, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/30106515/muscle-stem-cell-immunostaining
#4
Shuaiyu Wang, Bao Zhang, Gregory C Addicks, Hui Zhang, Keir J Menzies, Hongbo Zhang
Muscle stem cells (MuSCs) are essential for maintaining muscle homeostasis by providing progenitor cells for muscle regeneration after injury and in muscular diseases. MuSC properties dynamically change, reflecting physiology or pathological status. For instance, MuSCs are activated after muscle injury, but become exhausted in late stages of Duchenne Muscular Dystrophy (DMD) disease and senescent during aging. Therefore, characterization of MuSCs, including proliferation, activation, senescence, and apoptosis, etc...
August 14, 2018: Current Protocols in Mouse Biology
https://www.readbyqxmd.com/read/30106373/the-role-of-pitx2-and-pitx3-in-muscle-stem-cells-gives-new-insights-into-p38%C3%AE-map-kinase-and-redox-regulation-of-muscle-regeneration
#5
Aurore Lhonore, Pierre-Henri Commère, Elisa Negroni, Giorgia Pallafacchina, Bertrand Friguet, Jacques Drouin, Margaret Buckingham, Didier Montarras
Skeletal muscle regeneration depends on satellite cells. After injury these muscle stem cells exit quiescence, proliferate and differentiate to regenerate damaged fibres. We show that this progression is accompanied by metabolic changes leading to increased production of reactive oxygen species (ROS). Using Pitx2/3 single and double mutant mice that provide genetic models of deregulated redox states, we demonstrate that moderate overproduction of ROS results in premature differentiation of satellite cells while high levels lead to their senescence and regenerative failure...
August 14, 2018: ELife
https://www.readbyqxmd.com/read/30102621/understanding-sex-differences-in-the-regulation-of-cancer-induced-muscle-wasting
#6
Ryan N Montalvo, Brittany R Counts, James A Carson
PURPOSE OF REVIEW: We highlight evidence for sexual dimorphism in preclinical and clinical studies investigating the cause and treatment of cancer cachexia. RECENT FINDINGS: Cancer cachexia is unintended bodyweight loss occurring with cancer, and skeletal muscle wasting is a critical predictor of negative outcomes in the cancer patient. Skeletal muscle exhibits sexual dimorphism in fiber type, function, and regeneration capacity. Sex differences have been implicated in skeletal muscle metabolism, mitochondrial function, immune response to injury, and myogenic stem cell regulation...
August 9, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/30095484/proprioception-2-0-novel-functions-for-muscle-spindles
#7
Stephan Kröger
PURPOSE OF REVIEW: Muscle spindles are encapsulated mechanosensory receptors within skeletal muscle tissue that inform the central nervous system about the contractile status of each muscle. This information is required for any coordinated movement and for stable posture. This review summarizes recent findings regarding novel functions for proprioceptive feedback information, muscle spindle disease and the molecular basis of mechanoreception. RECENT FINDINGS: Muscle spindle function is not limited to regulating motor control but is also required for appropriate realignment of fractured bones, successful regeneration of spinal cord axons after injury and spinal alignment...
August 7, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/30089708/laminin-111-functionalized-polyethylene-glycol-hydrogels-support-myogenic-activity-i-in-vitro-i
#8
Natalia Ziemkiewicz, Muhamed Talovic, Josh Madsen, Lindsay Hill, Robert Scheidt, Anjali Patel, Gabriel Haas, Madison Marcinczyk, Silviya Zustiak, Koyal Garg
Skeletal muscle has a remarkable regenerative capability following mild physical or chemical insult. However, following a critical loss of muscle tissue, the regeneration process is impaired due to the inadequate myogenic activity of muscle resident stem cells (i.e., satellite cells). Laminin (LM) is a heterotrimeric structural protein in the satellite cell niche that is crucial for maintaining its function. In this study, we created hydrogels composed of poly (ethylene glycol) (PEG) and LM-111 to provide an elastic substrate for satellite cell proliferation at the site of injury...
August 9, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30081940/musclej-a-high-content-analysis-method-to-study-skeletal-muscle-with-a-new-fiji-tool
#9
Alicia Mayeuf-Louchart, David Hardy, Quentin Thorel, Pascal Roux, Lorna Gueniot, David Briand, Aurélien Mazeraud, Adrien Bouglé, Spencer L Shorte, Bart Staels, Fabrice Chrétien, Hélène Duez, Anne Danckaert
BACKGROUND: Skeletal muscle has the capacity to adapt to environmental changes and regenerate upon injury. To study these processes, most experimental methods use quantification of parameters obtained from images of immunostained skeletal muscle. Muscle cross-sectional area, fiber typing, localization of nuclei within the muscle fiber, the number of vessels, and fiber-associated stem cells are used to assess muscle physiology. Manual quantification of these parameters is time consuming and only poorly reproducible...
August 6, 2018: Skeletal Muscle
https://www.readbyqxmd.com/read/30079997/histological-examinations-of-the-in-vivo-biocompatibility-of-oxycellulose-implanted-into-rat-skeletal-muscle
#10
Christiane Kunert-Keil, Isabel Narath, Jakub Hadzik, Tomasz Gedrange, Tomasz Gredes, Marzena Dominiak
BACKGROUND: Recently it was shown that oxycellulose suppressed bone regeneration led to an accumulation of connective tissue as well as foam cells in bone defects. OBJECTIVES: Since oxycellulose can be used as a hemostatic agent in general and dental surgery, the aim of the study was to examine muscle tissue response to implanted oxidized cellulose. MATERIAL AND METHODS: RESO-Cell® (Resorba Wundversorgung GmbH, Nuremberg, Germany) standard was implanted in the latissimus dorsi of 20 rats; subsequently, 12 samples were processed for histological evaluation after 4 and 8 weeks...
August 6, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30077997/therapeutic-potential-of-human-adipose-derived-stem-cell-exosomes-in-stress-urinary-incontinence-an-in-vitro-and-in-vivo-study
#11
Jianshu Ni, Hongchao Li, Yiwen Zhou, Baojun Gu, Yuemin Xu, Qiang Fu, Xufeng Peng, Nailong Cao, Qingchun Fu, Meng Jin, Guangxi Sun, Jihong Wang, Yinpeng Jin, Feng Liu
BACKGROUND/AIMS: To evaluate whether local injection of exosomes derived from human adipose-derived stem cells (hADSCs) facilitates recovery of stress urinary incontinence (SUI) in a rat model. METHODS: For the in vitro study, a Cell Counting Kit-8 (CCK-8) array and proteomic analysis were performed. For the in vivo study, female rats were divided into four groups: sham, SUI, adipose-derived stem cell (ADSC), and exosomes (n = 12 each). The SUI model was generated by pudendal nerve transection and vaginal dilation...
August 3, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30074107/potential-pathogenic-role-of-anti-signal-recognition-protein-and-anti-3-hydroxy-3-methylglutaryl-coa-reductase-antibodies-in-immune-mediated-necrotizing-myopathies
#12
REVIEW
Leandro Ladislau, Louiza Arouche-Delaperche, Yves Allenbach, Olivier Benveniste
PURPOSE OF REVIEW: This review provides an overview of the potential pathogenic roles of anti-SRP and anti-HMGCR in IMNM over the past 5 years. RECENT FINDINGS: Idiopathic inflammatory myopathies (IIM) are a group of acquired autoimmune disorders that mainly affect the skeletal muscle tissue. Classification criteria of IIM are comprised of polymyositis, dermatomyositis, inclusion body myositis and immune-mediated necrotizing myopathies. One important hallmark of autoimmune diseases is the detection of autoantibodies in patient sera...
August 3, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/30073911/emerging-development-of-microfluidic-based-approaches-to-improve-studies-of-muscle-cell-migration
#13
Ziba Roveimiab, Francis Lin, Judy Anderson
Cell migration is an essential process in which cells move from one location to another with different modes, including mesenchymal, amoeboid or collective movements. Migration occurs during development and in the maintenance of multicellular organisms for purposes of wound healing, tissue regeneration, and immune and pathophysiological responses. Cells in all three types of muscle: cardiac, smooth, and skeletal, are subject to and undergo migration, both general and adapted for tissue-specific needs. Cardiac cell migration is mediated by vascular endothelial growth factor (VEGF) through expression of VEGF receptors; it is not clear how cardiac cells migrate into a region of damage after infarction...
August 3, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/30062184/transplantation-of-allogeneic-pw1-pos-pax7-neg-interstitial-cells-enhance-endogenous-repair-of-injured-porcine-skeletal-muscle
#14
Fiona C Lewis, Beverley J Cottle, Victoria Shone, Giovanna Marazzi, David Sassoon, Cheyenne C S Tseng, Patricia Y W Dankers, Steven A J Chamuleau, Bernardo Nadal-Ginard, Georgina M Ellison-Hughes
Skeletal muscle-derived PW1pos /Pax7neg interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofiber regeneration and neocapillarization, compared with saline vehicle control-treated muscles. Allogeneic pPICs did not contribute to new myofibers or capillaries and were eliminated by the host immune system. In conclusion, allogeneic pPIC transplantation stimulated the endogenous stem cell pool to bring about enhanced autologous skeletal muscle repair and regeneration...
December 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/30061815/growth-differentiation-factor-11-promotes-neurovascular-recovery-after-stroke-in-mice
#15
Lu Lu, Xiaofei Bai, Yongliang Cao, Haiyu Luo, Xing Yang, Lijing Kang, Mei-Juan Shi, Wenying Fan, Bing-Qiao Zhao
Background: Growth differentiation factor 11 (GDF11), a member of transforming growth factor-β (TGF-β) superfamily, was shown to rejuvenate cardiac and skeletal muscle function and to improve cerebral vasculature and neurogenesis in old mice. However, recent experimental data reported that raising GDF11 levels inhibited skeletal muscle regeneration and had no effect on cardiac hypertrophy. Our aim was to investigate the effects of GDF11 on brain repair during the recovery phase after stroke. Methods: Mice were subjected to distal middle cerebral artery occlusion, and recombinant GDF11 (rGDF11) was injected intraperitoneally once a day during days 7-13 after stroke...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/30057898/immune-regulation-of-tissue-repair-and-regeneration-via-mirnas-new-therapeutic-target
#16
REVIEW
Celeste Piotto, Ziad Julier, Mikaël M Martino
The importance of immunity in tissue repair and regeneration is now evident. Thus, promoting tissue healing through immune modulation is a growing and promising field. Targeting microRNAs (miRNAs) is an appealing option since they regulate immunity through post-transcriptional gene fine-tuning in immune cells. Indeed, miRNAs are involved in inflammation as well as in its resolution by controlling immune cell phenotypes and functions. In this review, we first discuss the immunoregulatory role of miRNAs during the restoration of tissue homeostasis after injury, focusing mainly on neutrophils, macrophages and T lymphocytes...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/30054310/distinct-metabolic-states-govern-skeletal-muscle-stem-cell-fates-during-prenatal-and-postnatal-myogenesis
#17
Francesca Pala, Daniela Di Girolamo, Sébastien Mella, Siham Yennek, Laurent Chatre, Miria Ricchetti, Shahragim Tajbakhsh
During growth, homeostasis and regeneration, stem cells are exposed to different energy demands. Here, we characterise the metabolic pathways that mediate the commitment and differentiation of mouse skeletal muscle stem cells, and how their modulation can influence the cell state. We show that quiescent satellite stem cells have low energetic demands and perturbed oxidative phosphorylation during ageing, which is also the case for cells from post-mortem tissues. We show also that myogenic fetal cells have distinct metabolic requirements compared to those proliferating during regeneration, with the former displaying a low respiration demand relying mostly on glycolysis...
July 27, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/30053299/effect-of-fungal-gamma-linolenic-acid-and-beta-carotene-containing-prefermented-feed-on-immunity-and-gut-of-broiler-chicken
#18
D Mudronová, V Karaffová, J Košcová, M Bartkovský, D Marcincáková, P Popelka, T Klempová, M Certík, J Macanga, S Marcincák
Gamma-linolenic acid (GLA) is a fatty acid from the ω-6 family. It is able to deliver a wide range of health benefits arising from its anti-inflammatory effects. An insufficient supply of GLA from agricultural and animal sources resulted in the development of a fermentation technique using lower filamentous fungi, which have the ability to accumulate high concentrations of GLA and beta-carotene during solid-state fermentation of cereals. The goal of this study was to observe the influence of the addition of prefermented cereal product, containing high amounts of GLA and beta-carotene, into the feed of broiler chickens on their immune status, and also the number of lactic acid bacteria and enterobacteria in gut content, which has never been studied before...
July 21, 2018: Poultry Science
https://www.readbyqxmd.com/read/30050646/mild-hyperthermia-induced-myogenic-differentiation-in-skeletal-muscle-cells-implications-for-local-hyperthermic-therapy-for-skeletal-muscle-injury
#19
Hojun Lee, Seung-Jun Choi
The percutaneous application of controlled temperature on damaged muscle is regarded as a prevalent remedy. However, specific mechanisms are not completely understood. Therefore, cellular behaviors of myoblasts were investigated under a physiological hyperthermic temperature. The myoblasts were cultured under no treatment (NT, 37°C, 24 h/day), intermittent heat treatment (IHT, 39°C, 2 h/day), and continuous heat treatment (CHT, 39°C, 24 h/day) during proliferation, migration, or myogenic differentiation...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30042129/the-transcription-factor-lef1-switches-partners-from-%C3%AE-catenin-to-smad3-during-muscle-stem-cell-quiescence
#20
Ajoy Aloysius, Ramanuj DasGupta, Jyotsna Dhawan
Skeletal muscle stem cells (MuSCs), also known as satellite cells, persist in adult mammals by entering a state of quiescence (G0 ) during the early postnatal period. Quiescence is reversed during damage-induced regeneration and re-established after regeneration. Entry of cultured myoblasts into G0 is associated with a specific, reversible induction of Wnt target genes, thus implicating members of the Tcf and Lef1 (Tcf/Lef) transcription factor family, which mediate transcriptional responses to Wnt signaling, in the initiation of quiescence...
July 24, 2018: Science Signaling
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