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Skeletal Muscle Regeneration

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https://www.readbyqxmd.com/read/30321814/prmt1-deficiency-in-mouse-juvenile-heart-induces-dilated-cardiomyopathy-and-reveals-cryptic-alternative-splicing-products
#1
Kazuya Murata, Weizhe Lu, Misuzu Hashimoto, Natsumi Ono, Masafumi Muratani, Kana Nishikata, Jun-Dal Kim, Shizufumi Ebihara, Junji Ishida, Akiyoshi Fukamizu
Protein arginine methyltransferase 1 (PRMT1) catalyzes the asymmetric dimethylation of arginine residues in proteins and methylation of various RNA-binding proteins and is associated with alternative splicing in vitro. Although PRMT1 has essential in vivo roles in embryonic development, CNS development, and skeletal muscle regeneration, the functional importance of PRMT1 in the heart remains to be elucidated. Here, we report that juvenile cardiomyocyte-specific PRMT1-deficient mice develop severe dilated cardiomyopathy and exhibit aberrant cardiac alternative splicing...
October 2, 2018: iScience
https://www.readbyqxmd.com/read/30321562/regulatory-t-cells-were-recruited-by-ccl3-to-promote-cryo-injured-muscle-repair
#2
Chaoqi Zhang, Yamin Qiao, Lan Huang, Feng Li, Zhen Zhang, Yu Ping, Zhibo Shen, Jingyao Lian, Feng Li, Lixuan Zhao, Yi Zhang
Skeletal muscle injury is a common symptom in daily life. After injury, a distinct population of regulatory T cells (Tregs) will infiltrate skeletal muscle in acute and chronic injury sites. However, the mechanism by which Tregs rapidly accumulate to the site of acute injury remains unclear. BALB/c mice were used to establish a cryo-injured model. Percentage of Tregs in the normal and cryo-injured tissues was detected on different days by flow cytometry. Then, the major factors that contribute to the repair of skeletal muscle by Tregs and the chemokines associated with the chemotaxis of Tregs in the paired muscle were analyzed by qRT-PCR...
October 12, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30319457/hdac4-regulates-skeletal-muscle-regeneration-via-soluble-factors
#3
Alessandra Renzini, Nicoletta Marroncelli, Chiara Noviello, Viviana Moresi, Sergio Adamo
Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells. Satellite cell behavior is tightly regulated by the surrounding microenvironment, which provides multiple signals derived from local cells and systemic factors. Among epigenetic mechanisms, histone deacetylation has been proved to affect muscle regeneration. Indeed, pan-histone deacetylase inhibitors were found to improve muscle regeneration, while deletion of histone deacetylase 4 (HDAC4) in satellite cells inhibits their proliferation and differentiation, leading to compromised muscle regeneration...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30317129/the-inclusion-complex-of-carvacrol-and-%C3%AE-cyclodextrin-reduces-acute-skeletal-muscle-inflammation-and-nociception-in-rats
#4
Ana Carla A Souza, Fabíula F Abreu, Lúcio R L Diniz, Renata Grespan, Josimari M DeSantana, Lucindo J Quintans-Júnior, Paula P Menezes, Adriano A S Araújo, Cristiane B Correa, Simone A Teixeira, Marcelo N Muscará, Soraia K P Costa, Enilton A Camargo
BACKGROUND: Skeletal muscle inflammation is strongly associated with pain and may impair regeneration and functional recovery after injury. Since anti-inflammatory and antinociceptive effects have been described for the inclusion complex of carvacrol and β-cyclodextrin (βCD-carvacrol), this study investigated the effects of βCD-carvacrol in a model of acute skeletal muscle inflammation. METHODS: Muscle injury was induced in male Wistar rats by injection of 3% carrageenan in the gastrocnemius muscle...
October 11, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/30314396/the-role-of-ampk-in-the-regulation-of-skeletal-muscle-size-hypertrophy-and-regeneration
#5
REVIEW
David M Thomson
AMPK (5'-adenosine monophosphate-activated protein kinase) is heavily involved in skeletal muscle metabolic control through its regulation of many downstream targets. Because of their effects on anabolic and catabolic cellular processes, AMPK plays an important role in the control of skeletal muscle development and growth. In this review, the effects of AMPK signaling, and those of its upstream activator, liver kinase B1 (LKB1), on skeletal muscle growth and atrophy are reviewed. The effect of AMPK activity on satellite cell-mediated muscle growth and regeneration after injury is also reviewed...
October 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30311453/anisotropically-aligned-cell-laden-nanofibrous-bundle-fabricated-via-cell-electrospinning-to-regenerate-skeletal-muscle-tissue
#6
Miji Yeo, Geun Hyung Kim
For muscle regeneration, a uniaxially arranged micropattern is important to mimic the structure of the natural extracellular matrix. Recently, cell electrospinning (CE) has been tested to fabricate cell-laden fibrous structures by embedding cells directly into micro/nanofibers. Although homogenous cell distribution and a reasonable cell viability of the cell-laden fibrous structure fabricated using the CE process are achieved, unique topographical cues formed by an aligned fibrous structure have not been applied...
October 11, 2018: Small
https://www.readbyqxmd.com/read/30310531/regulatory-role-of-sphingosine-kinase-and-sphingosine-1-phosphate-receptor-signaling-in-progenitor-stem-cells
#7
REVIEW
Mei Li Ng, Nagendra S Yarla, Mario Menschikowski, Olga A Sukocheva
Balanced sphingolipid signaling is important for the maintenance of homeostasis. Sphingolipids were demonstrated to function as structural components, second messengers, and regulators of cell growth and survival in normal and disease-affected tissues. Particularly, sphingosine kinase 1 (SphK1) and its product sphingosine-1-phosphate (S1P) operate as mediators and facilitators of proliferation-linked signaling. Unlimited proliferation (self-renewal) within the regulated environment is a hallmark of progenitor/stem cells that was recently associated with the S1P signaling network in vasculature, nervous, muscular, and immune systems...
September 26, 2018: World Journal of Stem Cells
https://www.readbyqxmd.com/read/30307112/generation-of-mlc-2v-tdtomato-knock-in-reporter-mouse-line
#8
Zhentao Zhang, Young-Jae Nam
MLC-2v is a myosin light chain regulatory protein which is specifically expressed in ventricular cardiomyocytes and slow twitch skeletal muscle cells. MLC-2v plays critical roles in ventricular maturation during heart development. Mice lacking MLC-2v are embryonic lethal due to heart failure associated with abnormal myofibrillar organization of ventricular cardiomyocytes. To study the development of ventricular cardiac muscle and slow twitch skeletal muscle, we generated a new MLC-2v reporter mouse line by knocking-in a tdTomato reporter cassette into 3' UTR of the MLC-2v gene without disrupting the endogenous gene...
October 11, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/30304405/embryonic-myosin-is-a-regeneration-marker-to-monitor-utrophin-based-therapies-for-dmd
#9
Simon Guiraud, Benjamin Edwards, Sarah E Squire, Lee Moir, Adam Berg, Arran Babbs, Nesrine Ramadan, Matthew J Wood, Kay E Davies
Duchenne muscular dystrophy (DMD) is a lethal, X-linked muscle-wasting disease caused by lack of the cytoskeletal protein dystrophin. Constitutive utrophin expression, a structural and functional paralogue of dystrophin, can successfully prevent the dystrophic pathology in the dystrophin-deficient mdx mouse model. In dystrophic muscles, utrophin is increased as part of the repair process and localised at the sarcolemma of regenerating myofibers. The presence of developmental myosin such as embryonic myosin (MyHC-emb) and neonatal (MyHC-neo) represents a useful marker of muscle regeneration and a meaningful indicator of muscle damage which correlates with the clinical severity of milder Becker Muscular dystrophy (BMD) and DMD patients...
October 9, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/30304034/hippo-signaling-pathway-is-altered-in-duchenne-muscular-dystrophy
#10
Gian Luca Vita, Francesca Polito, Rosaria Oteri, Roberto Arrigo, Anna Maria Ciranni, Olimpia Musumeci, Sonia Messina, Carmelo Rodolico, Rosa Maria Di Giorgio, Giuseppe Vita, M'Hammed Aguennouz
Hippo signaling pathway is considered a key regulator of tissue homeostasis, cell proliferation, apoptosis and it is involved in cancer development. In skeletal muscle, YAP, a downstream target of the Hippo pathway, is an important player in myoblast proliferation, atrophy/hypertrophy regulation, and in mechano-trasduction, transferring mechanical signals into transcriptional responses. We studied components of Hippo pathway in muscle specimens from patients with Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, limb-girdle muscular dystrophy type 2A and type 2B and healthy subjects...
2018: PloS One
https://www.readbyqxmd.com/read/30300394/muscle-regeneration-is-disrupted-by-cancer-cachexia-without-loss-of-muscle-stem-cell-potential
#11
Shoya Inaba, Atsushi Hinohara, Masashi Tachibana, Kazutake Tsujikawa, So-Ichiro Fukada
Cancer cachexia is a severe, debilitating condition characterized by progressive body wasting associated with remarkable loss of skeletal muscle weight. It has been reported that cancer cachexia disturbs the regenerative ability of skeletal muscle, but the cellular mechanisms are still unknown. Here, we investigated the skeletal muscle regenerative process in mouse colon-26 (C26) tumor cell-bearing mice as a C26 cancer cachexia model. Although the proliferation and differentiation abilities of muscle stem cells derived from the C26 tumor cell-bearing mice were sustained in vitro, the proliferation and differentiation were severely impaired in the cachexic mice...
2018: PloS One
https://www.readbyqxmd.com/read/30298751/adipose-derived-stem-stromal-cells-on-electrospun-fibrin-microfiber-bundles-enable-moderate-muscle-reconstruction-in-a-volumetric-muscle-loss-model
#12
Jordana Gilbert-Honick, Brian Ginn, Yuanfan Zhang, Sara Salehi, Kathryn R Wagner, Hai-Quan Mao, Warren L Grayson
Current treatment options for volumetric muscle loss (VML) are limited due to donor site morbidity, lack of donor tissue, and insufficient functional recovery. Tissue-engineered skeletal muscle grafts offer the potential to significantly improve functional outcomes. In this study, we assessed the potential pro-myogenic effects of human adipose-derived stem cells (ASCs) seeded onto electrospun uniaxially aligned fibrin hydrogel microfiber bundles. Although both uninduced and 5-azacytidine-induced ASCs exhibited alignment, elongation, and diffuse muscle marker expression when grown on microfiber bundles for 2 months in vitro, both groups failed to fully recapitulate myotube characteristics...
October 9, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/30294596/producing-3d-biomimetic-nanomaterials-for-musculoskeletal-system-regeneration
#13
REVIEW
Ignasi Casanellas, Andrea García-Lizarribar, Anna Lagunas, Josep Samitier
The human musculoskeletal system is comprised mainly of connective tissues such as cartilage, tendon, ligaments, skeletal muscle, and skeletal bone. These tissues support the structure of the body, hold and protect the organs, and are responsible of movement. Since it is subjected to continuous strain, the musculoskeletal system is prone to injury by excessive loading forces or aging, whereas currently available treatments are usually invasive and not always effective. Most of the musculoskeletal injuries require surgical intervention facing a limited post-surgery tissue regeneration, especially for widespread lesions...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/30290177/muscle-satellite-cell-cross-talk-with-a-vascular-niche-maintains-quiescence-via-vegf-and-notch-signaling
#14
Mayank Verma, Yoko Asakura, Bhavani Sai Rohit Murakonda, Thomas Pengo, Claire Latroche, Benedicte Chazaud, Linda K McLoon, Atsushi Asakura
Skeletal muscle is a complex tissue containing tissue resident muscle stem cells (satellite cells) (MuSCs) important for postnatal muscle growth and regeneration. Quantitative analysis of the biological function of MuSCs and the molecular pathways responsible for a potential juxtavascular niche for MuSCs is currently lacking. We utilized fluorescent reporter mice and muscle tissue clearing to investigate the proximity of MuSCs to capillaries in 3 dimensions. We show that MuSCs express abundant VEGFA, which recruits endothelial cells (ECs) in vitro, whereas blocking VEGFA using both a vascular endothelial growth factor (VEGF) inhibitor and MuSC-specific VEGFA gene deletion reduces the proximity of MuSCs to capillaries...
October 4, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/30286978/characterization-of-australian-labradoodle-dystrophinopathy
#15
Stephanie M Shrader, SeungWoo Jung, Thomas S Denney, Bruce F Smith
In humans, dystrophin mutations cause the X-linked recessive disorder known as Duchenne muscular dystrophy (DMD). These mutations result in skeletal and cardiac muscle damage with mortality increasingly associated with cardiomyopathy. We have identified a novel dystrophin mutation in exon 21 in a line of Australian Labradoodles; affected dogs develop progressive clinical signs including poor weight gain and weight loss, gait abnormalities, exercise intolerance, skeletal muscle atrophy, macroglossa, ptyalism, dysphagia, kyphosis, and a plantigrade stance...
August 29, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/30284969/cellular-localization-of-the-cell-cycle-inhibitor-cdkn1c-controls-growth-arrest-of-adult-skeletal-muscle-stem-cells
#16
Despoina Mademtzoglou, Yoko Asakura, Matthew J Borok, Sonia Alonso-Martin, Philippos Mourikis, Yusaku Kodaka, Amrudha Mohan, Atsushi Asakura, Frederic Relaix
Adult skeletal muscle maintenance and regeneration depend on efficient muscle stem cell (MuSC) functions. The mechanisms coordinating cell cycle with activation, renewal, and differentiation of MuSCs remain poorly understood. Here, we investigated how adult MuSCs are regulated by <u> <u>CDKN1c</u> </u> (p57kip2 ), a cyclin-dependent kinase inhibitor, using mouse molecular genetics. In the absence of <u> <u>CDKN1c</u> </u>, skeletal muscle repair is severely impaired after injury...
October 4, 2018: ELife
https://www.readbyqxmd.com/read/30282842/glycerol-induces-early-fibrosis-in-regenerating-rat-skeletal-muscle
#17
Mohamed A A Mahdy, Katsuhiko Warita, Yoshinao Z Hosaka
Glycerol has been recently used to induce muscle adiposity in mice. However, its effects on the rat muscles have not been investigated previously. Therefore, we investigated the regeneration outcomes of rat muscles following glycerol-induced injury at different time points. Glycerol injection induced myofiber degeneration with extensive inflammatory infiltration on day 4 followed by appearance of regenerating myotubes on day 7 after injury without adipocyte infiltration. Meanwhile, a significant collagen deposition at early stage of regeneration that increased together with persistent inflammatory infiltration up to day 14 after injury indicates impaired regeneration...
October 2, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/30279563/the-imprinted-gene-pw1-peg3-regulates-skeletal-muscle-growth-satellite-cell-metabolic-state-and-self-renewal
#18
Rosa Maria Correra, David Ollitrault, Mariana Valente, Alessia Mazzola, Bjorn T Adalsteinsson, Anne C Ferguson-Smith, Giovanna Marazzi, David A Sassoon
Pw1/Peg3 is an imprinted gene expressed from the paternally inherited allele. Several imprinted genes, including Pw1/Peg3, have been shown to regulate overall body size and play a role in adult stem cells. Pw1/Peg3 is expressed in muscle stem cells (satellite cells) as well as a progenitor subset of muscle interstitial cells (PICs) in adult skeletal muscle. We therefore examined the impact of loss-of-function of Pw1/Peg3 during skeletal muscle growth and in muscle stem cell behavior. We found that constitutive loss of Pw1/Peg3 function leads to a reduced muscle mass and myofiber number...
October 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30275345/hsp70-interacts-with-mapk-activated-protein-kinase-2-to-regulate-p38mapk-stability-and-myoblast-differentiation-during-skeletal-muscle-regeneration
#19
Wei Fan, Xiu Kui Gao, Xi Sheng Rao, Yin Pu Shi, Xiao Ceng Liu, Fei Ya Wang, Yu Fen Liu, Xiao Xia Cong, Min Yi He, Shui Bo Xu, Wei Liang Shen, Yue Shen, Shi Gui Yan, Yan Luo, Boon Chuan Low, Hongwei Ouyang, Zhang Bao, Li Ling Zheng, Yi Ting Zhou
The regenerative process of injured muscle is dependent on the fusion and differentiation of myoblast cells derived from muscle stem cells. Hsp70 is important for maintaining skeletal muscle homeostasis and regeneration but the precise cellular mechanism remains elusive. Here we found that Hsp70 was upregulated during myoblast differentiation. Depletion or inhibition of Hsp70/Hsc70 impaired myoblast differentiation. Importantly, overexpression of p38MAPKα, but not AKT1, rescued the impairment of myogenic differentiation in Hsp70- or Hsc70-depleted myoblasts...
October 1, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/30275293/functional-muscle-recovery-with-nanoparticle-directed-m2-macrophage-polarization-in-mice
#20
Theresa M Raimondo, David J Mooney
Persistence of inflammation, and associated limits in tissue regeneration, are believed to be due in part to the imbalance of M1 over M2 macrophages. Here, we hypothesized that providing a sustained source of an antiinflammatory polarizing cytokine would shift the balance of macrophages at a site of tissue damage to improve functional regeneration. Specifically, IL-4-conjugated gold nanoparticles (PA4) were injected into injured murine skeletal muscle, resulting in improved histology and an ∼40% increase in muscle force compared with mice treated with vehicle only...
October 1, 2018: Proceedings of the National Academy of Sciences of the United States of America
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