João Franco Machado, Marco Sá, Inês Pires, Miguel Tarita da Silva, Fernanda Marques, Jaime A S Coelho, Filipa Mendes, M Fátima M Piedade, Miguel Machuqueiro, María Angeles Jiménez, Maria Helena Garcia, João D G Correia, Tânia S Morais
Dysregulation of Fibroblast Growth Factor Receptors (FGFRs) signaling has been associated with breast cancer, yet employing FGFR-targeted delivery systems to improve the efficacy of cytotoxic agents is still sparsely exploited. Herein, we report four new bi-functional ruthenium-peptide conjugates (RuPCs) with FGFR-targeting and pH-dependent releasing abilities, envisioning the selective delivery of cytotoxic Ru complexes to FGFR(+)-breast cancer cells, and controlled activation at the acidic tumoral microenvironment...
April 4, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry