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Botox weight reduction

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https://www.readbyqxmd.com/read/29371611/enhanced-skin-permeation-of-anti-wrinkle-peptides-via-molecular-modification
#1
Seng Han Lim, Yuanyuan Sun, Thulasi Thiruvallur Madanagopal, Vinicius Rosa, Lifeng Kang
Wrinkles can have a negative effect on quality of life and Botox is one of the most effective and common treatments. Argireline (Arg0), a mimetic of Botox, has been found to be safer than Botox and effective in reducing wrinkles, with efficacies up to 48% upon 4 weeks of twice daily treatment. However, the skin permeation of Arg0 is poor, due to its large molecular weight and hydrophilicity. Arg0 exists in zwitterionic form and this charged state hindered its skin permeation. Chemical modification of the peptide structure to reduce the formation of zwitterions may result in increased skin permeability...
January 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/28654594/comparison-of-steroid-and-botulinum-toxin-type-a-monotherapy-with-combination-therapy-for-treating-human-hypertrophic-scars-in-an-animal-model
#2
COMPARATIVE STUDY
Hung-Chang Chen, Cheng-I Yen, Shih-Yi Yang, Cheng-Jen Chang, Jui-Yung Yang, Shu-Yin Chang, Shiow-Shuh Chuang, Yen-Chang Hsiao
BACKGROUND: The authors evaluated the efficacy of a combined regimen of botulinum toxin type A (Botox) and a steroid (triamcinolone acetonide) for treating hypertrophic scars in comparison with the treatment with each drug alone. METHODS: Twenty excised human hypertrophic scar fragments obtained from surgically treated burn patients were divided into four groups: negative control (group A), triamcinolone alone (group B), Botox alone (group C), and a combination of triamcinolone and Botox (group D)...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/26753166/early-effect-of-botox-a-injection-into-the-masseter-muscle-of-rats-functional-and-histological-evaluation
#3
Young-Min Moon, Young-Jun Kim, Min-Keun Kim, Seong-Gon Kim, HaeYong Kweon, Tae-Woo Kim
BACKGROUND: The purpose of this study was to evaluate the change of food intake after different dosages of botulinum toxin A (BTX) injection in the animal model. Additionally, the dimensional and histological change at 14 days after BTX injection was also evaluated. METHODS: The comparative study was performed using the BTX injection model in rats ( n  = 5 for each group). Group 1 was the saline-injected group. Group 2 was the 5-unit BTX-injection group to each masseter muscle...
December 2015: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/21194973/the-effect-of-muscle-paralysis-using-botox-on-the-healing-of-tendon-to-bone-in-a-rat-model
#4
COMPARATIVE STUDY
Carolyn M Hettrich, Scott A Rodeo, Jo A Hannafin, John Ehteshami, Beth E Shubin Stein
HYPOTHESIS: Despite good clinical results after rotator cuff repair, follow-up studies show significant rates of failed healing. This may be because of excessive tension on the repaired tendon due to shoulder motion. We hypothesized that botulinum toxin A injections would result in improved attachment strength and collagen organization at the tendon-bone interface at early time points but may result in decreased mechanical properties at later time points because of the negative effects of stress deprivation...
July 2011: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/20852412/systemic-weakness-after-therapeutic-injections-of-botulinum-toxin-a-a-case-series-and-review-of-the-literature
#5
REVIEW
Beth E Crowner, Diego Torres-Russotto, Alexandre R Carter, Brad A Racette
The use of intramuscular injections of Botulinum neurotoxin A (BoNT-A) is common in the treatment of hypertonicity and movement disorders. Although most side effects are mild, systemic effects, manifested by generalized weakness distant from the site of injection, have been reported. Previously reported occurrences are discussed, and 3 new cases of patients, who developed systemic weakness after administration of BoNT-A (Botox), despite having tolerated similar injections on several previous occasions, are presented...
September 2010: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/16197786/effect-on-gastric-emptying-and-weight-reduction-of-botulinum-toxin-a-injection-into-the-gastric-antral-layer-an-experimental-study-in-the-obese-rat-model
#6
Halil Coskun, Yasin Duran, Ece Dilege, Mehmet Mihmanli, Hulya Seymen, Mehmet Onur Demirkol
BACKGROUND: We investigated the effects of Botox-A on weight loss and gastric emptying in an experimental obese rat model. Although there is evidence of weight loss in normal-weight rats after Botox-A injection, there are no studies indicating the effect of Botox-A injection on weight loss and gastric emptying time in obese rats. METHODS: 37 female Wistar Albino rats were given high calorie diet for 90 days. They were separated into 3 groups. The first group (Botox group) consisted of 15 obese rats whose gastric antrum was injected with 20 U of Botulinum Toxin Type A...
September 2005: Obesity Surgery
https://www.readbyqxmd.com/read/16185943/botox-induced-muscle-paralysis-rapidly-degrades-bone
#7
Sarah E Warner, David A Sanford, Blair A Becker, Steven D Bain, Sundar Srinivasan, Ted S Gross
The means by which muscle function modulates bone homeostasis is poorly understood. To begin to address this issue, we have developed a novel murine model of unilateral transient hindlimb muscle paralysis using botulinum toxin A (Botox). Female C57BL/6 mice (16 weeks) received IM injections of either saline or Botox (n = 10 each) in both the quadriceps and calf muscles of the right hindleg. Gait dysfunction was assessed by multi-observer inventory, muscle alterations were determined by wet mass, and bone alterations were assessed by micro-CT imaging at the distal femur, proximal tibia, and tibia mid-diaphysis...
February 2006: Bone
https://www.readbyqxmd.com/read/14741072/effect-of-preventive-treatment-with-botulinum-toxin-type-a-on-acute-headache-medication-usage-in-migraine-patients
#8
REVIEW
Jack Schim
OBJECTIVE: To evaluate the impact of preventive treatment of migraine with botulinum toxin type A (BoNT-A as BOTOX) on the amount of acute headache medications used. RESEARCH DESIGN AND METHODS: Data from four studies of BoNT-A treatment for migraine were pooled for an aggregate analysis. All studies were at least 12 weeks in duration. For each study, the amounts of headache medications used at weeks 8-12 following BoNT-A treatment were compared with pretreatment baseline amounts and expressed preventive headache care considering acute as a percentage change...
January 2004: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/10430676/laparoscopic-heller-s-myotomy-or-botulinum-toxin-injection-for-management-of-esophageal-achalasia-patient-choice-and-treatment-outcomes
#9
COMPARATIVE STUDY
C N Andrews, M Anvari, J Dobranowski
BACKGROUND: Esophageal achalasia is a rare disease in which degenerating parasympathetic innervation of the lower esophageal sphincter (LES) leads to unopposed sympathetic tone and failure to relax on deglutition, resulting in a range of symptoms for the patient, most notably dysphagia, chest pain, regurgitation, and weight loss. Laparoscopic Heller's esophagomyotomy (Lap-HM) and botulinum toxin (BoTox) injection into the LES are two recently described methods for treating achalasia. No comparison of laparoscopic Heller's myotomy and botulinum toxin has yet been presented...
August 1999: Surgical Endoscopy
https://www.readbyqxmd.com/read/9180950/-botulinum-toxin-is-effective-in-the-short-term-treatment-of-esophageal-achalasia-preliminary-results-of-a-randomized-trial
#10
RANDOMIZED CONTROLLED TRIAL
A Fiorini, R E Corti, J L Valero, J C Bai, L Boerr
UNLABELLED: Botulinum toxin (BoTox) is a potent inhibitor of the release of acetylcholine from terminal nerves and has been used successfully in spastic disorders of skeletal muscle. Its used for the treatment of disorders of gastrointestinal smooth muscle has recently been explored. In this study we evaluated the efficacy of transendoscopic injection of BoTox in 13 symptomatic patients with achalasia G II (Siewert classification) without previous treatment of an ongoing randomized-controlled trial...
1996: Acta Gastroenterologica Latinoamericana
https://www.readbyqxmd.com/read/8370782/management-of-cerebral-palsy-with-botulinum-a-toxin-preliminary-investigation
#11
L A Koman, J F Mooney, B Smith, A Goodman, T Mulvaney
Use of intramuscular botulinum-A toxin (Botox) to produce neuromuscular blockade has been effective in treating certain ocular and facial muscular imbalances as well as spasmodic torticollis. In this preliminary open study, the effectiveness of intramuscularly injected Botox on the muscular imbalances of cerebral palsy was assessed in 27 pediatric patients. Each patient had "dynamic deformities" unresponsive to other treatment, and operation was the only other realistic alternative. The dose of Botox was calculated on a unit/body weight basis...
July 1993: Journal of Pediatric Orthopedics
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