keyword
https://read.qxmd.com/read/35509758/a-rare-case-of-esophageal-leukoplakia-in-achalasia
#1
Gowthami Kanagalingam, Yvette Achuo-Egbe, Mirza Fawad Ahmed, Oladimeji Oluaderounmu, Jennifer Harley
Esophageal leukoplakia refers to a clinical finding of a white patch on the mucous membrane surface that cannot be scraped off. It has been associated with alcohol and tobacco use and chronic acid reflux. An association with squamous cell dysplasia and carcinoma has been reported with potential for malignant transformation warranting endoscopic intervention or surveillance, but no guidelines exist. We present a case of a 77-year-old female with a history of longstanding achalasia requiring multiple Botox injections...
April 2022: Curēus
https://read.qxmd.com/read/35476783/botulinum-injection-into-the-proximal-intestinal-wall-of-diet-induced-obese-mice-leads-to-weight-loss-and-improves-glucose-and-fat-tolerance
#2
JOURNAL ARTICLE
Sinju Sundaresan, Joseph Antoun, Babak Banan, Jamie Adcock, Connor Johnson, Brendan Claire, Kala Dixon, Joyce Flynn, Cyndya A Shibao, Naji Abumrad
Botulinum neurotoxin (available commercially as BOTOX) has been used successfully for treatment of several neuromuscular disorders, including blepharospasm, dystonia, spasticity, and cerebral palsy in children. Our data demonstrate that injection of Botox into the proximal intestinal wall of diet-induced obese (DIO) mice induces weight loss and reduces food intake. This was associated with amelioration of hyperglycemia, hyperlipidemia, and significant improvement of glucose tolerance without alteration of energy expenditure...
July 1, 2022: Diabetes
https://read.qxmd.com/read/34716460/therapeutic-efficacy-of-new-botulinum-toxin-identified-in-ccug-7968-strain
#3
JOURNAL ARTICLE
Yeongduk An, Young-Je Kim, Chung-Sei Kim, Hyeona Yim, Myungseob Kim, Eui-Kyung Lee, Hyeon-Ji Oh, Jun-Hyeok Han, Eunseon Yoo, Sunghyun Kim, Joongseok Woo, Edward R B Moore, Ji-Youn Jung, Wooram Park
Botulinum neurotoxin type A (BoNT/A) induces muscle atrophy by cleaving synaptosomal-associated protein 25. Thus, BoNT/A has been actively utilized for the treatment of masseter and gastrocnemius hypertrophy. In this study, INI101 toxin was newly identified from the CCUG 7968 strain, and its therapeutic efficacy was evaluated both in vitro and in vivo. The INI101 toxin showed identical genetic sequence, amino acid sequence, and protein subunit composition to BoNT/A produced from strain Hall A. Electromyography (EMG), and immunofluorescence staining demonstrated that INI101 (at 2 ~ 8 U/rat) effectively blocked the neuromuscular junction with no toxicity in a rat model...
December 2021: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/33893767/gastric-botulinum-toxin-a-application-for-weight-loss-therapy
#4
JOURNAL ARTICLE
Ozan Şen, Ahmet Gökhan Türkçapar
BACKGROUND/AIMS: The aim of this study is to share the results of gastric botulinum toxin (BTX) application in individuals who are overweight or type 1 obese without comorbidity. MATERIALS AND METHODS: In this study, 13 patients were included who were enrolled for gastric BTX application for the first time. A total of 300 U of BTX-A (Allergan Botox ®1 vial 100 U) was diluted with 8 mL of 0.9% NaCl saline, and antrum (100 U to 8 spots), corpus (100 U to 8 spots), and fundus (100 U to 8 spots) regions were injected intramuscularly...
January 2021: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://read.qxmd.com/read/33062839/is-intragastric-botulinum-toxin-a-injection-effective-in-obesity-treatment
#5
JOURNAL ARTICLE
Bulent Kaya, Nuriye Esen Bulut, Mahir Fersahoglu
AIMS: The objective of this prospective study was to evaluate the efficacy of intragastric botulinum toxin A (BTX-A) injection for the treatment of obesity. MATERIALS AND METHODS: The study was performed between January and August 2019. This is a prospective study. After 6-12 hours of fasting, the patients were submitted to upper GI endoscopy under sedation for the injection of BTX-A. A total of 250 U of BTA-X was diluted with 10 ml of 0.9% saline...
2020: Surgery Research and Practice
https://read.qxmd.com/read/31792900/gastric-per-oral-pyloromyotomy-for-post-vagotomy-induced-gastroparesis-following-esophagectomy
#6
JOURNAL ARTICLE
Mark J Anderson, Megan Sippey, Jeffrey Marks
BACKGROUND: Following the success of per-oral endoscopic myotomy (POEM) for achalasia, application of this minimally invasive skillset has broadened to other disease processes. Since 2013, gastric per-oral pyloromyotomy (GPOP) has become an increasingly accepted therapy for refractory gastroparesis. Although it does not treat the underlying etiology of the disease, pyloromyotomy has demonstrated measurable improvements in gastric emptying scintigraphy, nausea, and quality of life. Gastroparesis is a common complication of esophagectomy due to the inherent vagotomy that occurs during creation of the gastric conduit...
March 2020: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/31715339/changes-in-mechanical-loading-affect-arthritis-induced-bone-loss-in-mice
#7
JOURNAL ARTICLE
Anna-Maria Liphardt, Sara H Windahl, Edina Sehic, Nicole Hannemann, Karin L Gustafsson, Aline Bozec, Georg Schett, Cecilia Engdahl
Arthritis induces bone loss by inflammation-mediated disturbance of bone homeostasis. On the other hand, pain and impaired locomotion are highly prevalent in arthritis and result in reduced general physical activity and less pronounced mechanical loading. Bone is affected by mechanical loading, directly through impact with the ground during movement and indirectly through muscular activity. Mechanical loading in its physiological range is essential for maintaining bone mass, whereas disuse leads to bone loss...
February 2020: Bone
https://read.qxmd.com/read/30720423/achalasia-insights-into-diagnostic-and-therapeutic-advances-for-an-ancient-disease
#8
REVIEW
Amir Mari, Kalp Patel, Mahmud Mahamid, Tawfik Khoury, Marcella Pesce
Achalasia is a chronic idiopathic disease characterized by the absence of esophageal body peristalsis and by defective lower esophageal sphincter (LES) relaxation. The incidence rate ranges from 1.07 to up to 2.8 new cases per year per 100,000 population. Presenting symptoms include dysphagia, regurgitation, vomiting, and weight loss. The diagnosis of achalasia has undergone a revolution in the last decade due to the advent of high-resolution manometry (HRM) and the consequent development of the Chicago Classification...
January 28, 2019: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/30343548/-achalasia-updates-on-diagnosis-and-management-from-the-last-decade
#9
REVIEW
Amir Mari, Fadi Abu Backer, Hana Amara, Mahmud Mahamid
Achalasia is a rare idiopathic disease, associated with significant morbidity and negative impact on life quality. The disorder is characterized by impairments in the esophageal motility and loss of the lower esophageal sphincter (LES) relaxation. Achalasia symptoms include dysphagia, regurgitations, chest pain, vomiting and weight loss. Diagnosis of achalasia is based on an appropriate clinical presentation and typical findings on complementary tests. These tests include endoscopy showing a dilated esophageal lumen containing fluid or food, High-resolution manometry (HRM) shows evidence of obstruction at the gastro-esophageal junction and motility failure, and barium swallow shows esophageal dilation and distal narrowing...
October 2018: Harefuah
https://read.qxmd.com/read/27571581/achalasia-from-diagnosis-to-management
#10
REVIEW
Michael F Vaezi, Valter N Felix, Roberto Penagini, Aurelio Mauro, Eduardo Guimarães Hourneaux de Moura, Leonardo Zorrón Cheng Tao Pu, Jan Martínek, Erwin Rieder
Achalasia is an esophageal motility disorder associated with abnormalities in peristalsis and lower esophageal sphincter (LES) relaxation. The etiology of the disease remains elusive. It is often misdiagnosed initially as gastroesophageal reflux disease. Patients with achalasia often complain of dysphagia to solids and liquids but may focus on regurgitation as the primary symptom, leading to the early misdiagnosis. Chest pain, weight loss, and occasional vomiting may be additional symptoms encountered in those with achalasia...
October 2016: Annals of the New York Academy of Sciences
https://read.qxmd.com/read/27354102/gastric-per-oral-endoscopic-myotomy-for-refractory-gastroparesis-results-from-the-first-multicenter-study-on-endoscopic-pyloromyotomy-with-video
#11
MULTICENTER STUDY
Mouen A Khashab, Saowanee Ngamruengphong, David Carr-Locke, Amol Bapaye, Petros C Benias, Sam Serouya, Shivangi Dorwat, Dalton M Chaves, Everson Artifon, Eduardo G de Moura, Vivek Kumbhari, Yamile Haito Chavez, Majidah Bukhari, Gulara Hajiyeva, Amr Ismail, Yen-I Chen, Hyunsoo Chung
BACKGROUND AND AIMS: Gastric per-oral endoscopic myotomy (G-POEM) recently has been reported as minimally invasive therapy for gastroparesis. The aims of this study were to report on the first multicenter experience with G-POEM and to assess the efficacy and safety of this novel procedure for patients with gastroparesis with symptoms refractory to medical therapy. METHODS: All patients with gastroparesis who underwent endoscopic pyloromyotomy (G-POEM) at 5 medical centers were included...
January 2017: Gastrointestinal Endoscopy
https://read.qxmd.com/read/27174454/jackhammer-oesophagus-in-a-case-of-linitis-plastica
#12
JOURNAL ARTICLE
Naueen Akbar Chaudhry, Kamran Zahid, Roxana Coman, Qing Zhang
A 52-year-old Caucasian woman presented with progressive nausea and vomiting, weight loss, and burning epigastric and chest pain. Initial oesophagogastroduodenoscopy (OGD) with biopsies demonstrated gastritis in absence of Helicobacter pylori A gastric emptying study, CT scan with pancreatic protocol and a colonoscopy revealed no concerning findings. Calcium channel blockers and proton pump inhibitors offered little improvement. A high-resolution oesophageal impedance manometry was performed, which was significant for jackhammer oesophagus with maximum distal contractile index 11 052 mm Hg-s-cm...
May 12, 2016: BMJ Case Reports
https://read.qxmd.com/read/23974310/mesotherapy-cosmetic-applications
#13
JOURNAL ARTICLE
Jill Stachowski, Kayla Botts, Lesley Rine, Danielle Kato, Jennifer Pollock
Mesotherapy, which has been compared to the anti-wrinkle injection Botox, has only recently become popular in the United States for providing body contouring and spot weight loss. Most adverse reactions associated with mesotherapy are mild and transient, and supporters of the procedure consider it a safer alternative to liposuction. Mainly owing to the absence of safety and efficacy data pertaining to mesotherapy, liposuction is currently the only method for fat removal that is endorsed by the American Society of Plastic Surgeons ...
September 2006: International Journal of Pharmaceutical Compounding
https://read.qxmd.com/read/23388417/reduced-gravitational-loading-does-not-account-for-the-skeletal-effect-of-botulinum-toxin-induced-muscle-inhibition-suggesting-a-direct-effect-of-muscle-on-bone
#14
JOURNAL ARTICLE
Stuart J Warden, Matthew R Galley, Jeffrey S Richard, Lydia A George, Rachel C Dirks, Elizabeth A Guildenbecher, Ashley M Judd, Alexander G Robling, Robyn K Fuchs
Intramuscular injection of botulinum toxin (botox) into rodent hindlimbs has developed as a useful model for exploring muscle-bone interactions. Botox-induced muscle inhibition rapidly induces muscle atrophy and subsequent bone loss, with the latter hypothesized to result from reduced muscular loading of the skeleton. However, botox-induced muscle inhibition also reduces gravitational loading (as evident by reduced ground reaction forces during gait) which may account for its negative skeletal effects. The aim of this study was to investigate the skeletal effect of botox-induced muscle inhibition in cage control and tail suspended mice, with tail suspension being used to control for the reduced gravitational loading associated with botox...
May 2013: Bone
https://read.qxmd.com/read/23246791/pth-1-34-but-not-strontium-ranelate-counteract-loss-of-trabecular-thickness-and-bone-strength-in-disuse-osteopenic-rats
#15
JOURNAL ARTICLE
Annemarie Brüel, Jens Bay Vegger, Anders Christer Raffalt, Jens Enevold Thaulov Andersen, Jesper Skovhus Thomsen
PTH and strontium ranelate (SrR) have both been shown to reduce bone loss induced by immobilization. PTH is a potent bone anabolic agent, whereas SrR has been suggested to be an antiresorptive as well as a bone anabolic agent. The aim of the study was to investigate whether PTH, SrR, and PTH and SrR in combination could counteract immobilization-induced bone loss in a rat model. Immobilization was induced by injecting 4IU Botox (BTX) into the muscles of the right hind limb. Seventy-two female Wistar rats, 3-months-old, were divided into the following groups: Baseline, Controls, BTX, BTX+PTH, BTX+SrR, and BTX+PTH+SrR (n=12 in each group)...
March 2013: Bone
https://read.qxmd.com/read/21930998/predictors-of-long-term-outcome-after-laparoscopic-esophagomyotomy-and-dor-fundoplication-for-achalasia
#16
JOURNAL ARTICLE
Jonathan T Carter, Dennis Nguyen, Garrett R Roll, Sandi W Ma, Lawrence W Way
OBJECTIVE: To identify predictors of long-term outcome of laparoscopic Heller myotomy for achalasia, including predictors of heartburn and recurrent dysphagia, which occasionally develop postoperatively. DESIGN: Retrospective review using interviews of patients. SETTING: Academic university hospital. PATIENTS: One hundred sixty-five patients with achalasia who underwent a laparoscopic esophagomyotomy and Dor fundoplication...
September 2011: Archives of Surgery
https://read.qxmd.com/read/17216576/the-use-of-the-internet-in-data-assimilation-in-rare-diseases
#17
JOURNAL ARTICLE
Raymond Bedgood, Rafal Sadurski, Robert R Schade
The incidence and prevalence of achalasia is 0.6/100,000 people per year and 1/10,000, respectively. It is difficult then for one center to accumulate a large cohort of patients. One study (Gut 33:1011,1992) described the presenting symptoms in only 38 patients. To approach this problem differently, we used the internet to access a larger patient population. Using search engines at Google and Yahoo, Inc., we identified achalasia support groups. We examined the most populated support group (YSG) and assembled the exchanged messages into 4 categories: support, symptoms, treatment, and diagnosis...
February 2007: Digestive Diseases and Sciences
https://read.qxmd.com/read/16416206/achalasia-in-a-patient-with-gastroesophageal-varices-problematic-treatment-decisions
#18
JOURNAL ARTICLE
Hugo Pinillos, Peter Legnani, Thomas Schiano
The coexistence of achalasia and gastroesophageal varices has been reported sporadically in the English medical literature. We report the case of a 60-year-old Hispanic woman with cryptogenic cirrhosis who was referred for a liver transplant evaluation and subsequently developed progressive dysphagia to both solids and liquids as well as substernal chest pain and weight loss. Endoscopy revealed the presence of grade I esophageal varices and large fundic varices, as well as retained liquid and solid food in the distal esophagus...
January 2006: Digestive Diseases and Sciences
https://read.qxmd.com/read/16197786/effect-on-gastric-emptying-and-weight-reduction-of-botulinum-toxin-a-injection-into-the-gastric-antral-layer-an-experimental-study-in-the-obese-rat-model
#19
JOURNAL ARTICLE
Halil Coskun, Yasin Duran, Ece Dilege, Mehmet Mihmanli, Hulya Seymen, Mehmet Onur Demirkol
BACKGROUND: We investigated the effects of Botox-A on weight loss and gastric emptying in an experimental obese rat model. Although there is evidence of weight loss in normal-weight rats after Botox-A injection, there are no studies indicating the effect of Botox-A injection on weight loss and gastric emptying time in obese rats. METHODS: 37 female Wistar Albino rats were given high calorie diet for 90 days. They were separated into 3 groups. The first group (Botox group) consisted of 15 obese rats whose gastric antrum was injected with 20 U of Botulinum Toxin Type A...
September 2005: Obesity Surgery
https://read.qxmd.com/read/16185943/botox-induced-muscle-paralysis-rapidly-degrades-bone
#20
JOURNAL ARTICLE
Sarah E Warner, David A Sanford, Blair A Becker, Steven D Bain, Sundar Srinivasan, Ted S Gross
The means by which muscle function modulates bone homeostasis is poorly understood. To begin to address this issue, we have developed a novel murine model of unilateral transient hindlimb muscle paralysis using botulinum toxin A (Botox). Female C57BL/6 mice (16 weeks) received IM injections of either saline or Botox (n = 10 each) in both the quadriceps and calf muscles of the right hindleg. Gait dysfunction was assessed by multi-observer inventory, muscle alterations were determined by wet mass, and bone alterations were assessed by micro-CT imaging at the distal femur, proximal tibia, and tibia mid-diaphysis...
February 2006: Bone
keyword
keyword
169718
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.