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https://www.readbyqxmd.com/read/27571581/achalasia-from-diagnosis-to-management
#1
REVIEW
Michael F Vaezi, Valter N Felix, Roberto Penagini, Aurelio Mauro, Eduardo Guimarães Hourneaux de Moura, Leonardo Zorrón Cheng Tao Pu, Jan Martínek, Erwin Rieder
Achalasia is an esophageal motility disorder associated with abnormalities in peristalsis and lower esophageal sphincter (LES) relaxation. The etiology of the disease remains elusive. It is often misdiagnosed initially as gastroesophageal reflux disease. Patients with achalasia often complain of dysphagia to solids and liquids but may focus on regurgitation as the primary symptom, leading to the early misdiagnosis. Chest pain, weight loss, and occasional vomiting may be additional symptoms encountered in those with achalasia...
October 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27354102/gastric-per-oral-endoscopic-myotomy-for-refractory-gastroparesis-results-from-the-first-multicenter-study-on-endoscopic-pyloromyotomy-with-video
#2
MULTICENTER STUDY
Mouen A Khashab, Saowanee Ngamruengphong, David Carr-Locke, Amol Bapaye, Petros C Benias, Sam Serouya, Shivangi Dorwat, Dalton M Chaves, Everson Artifon, Eduardo G de Moura, Vivek Kumbhari, Yamile Haito Chavez, Majidah Bukhari, Gulara Hajiyeva, Amr Ismail, Yen-I Chen, Hyunsoo Chung
BACKGROUND AND AIMS: Gastric per-oral endoscopic myotomy (G-POEM) recently has been reported as minimally invasive therapy for gastroparesis. The aims of this study were to report on the first multicenter experience with G-POEM and to assess the efficacy and safety of this novel procedure for patients with gastroparesis with symptoms refractory to medical therapy. METHODS: All patients with gastroparesis who underwent endoscopic pyloromyotomy (G-POEM) at 5 medical centers were included...
January 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27174454/jackhammer-oesophagus-in-a-case-of-linitis-plastica
#3
Naueen Akbar Chaudhry, Kamran Zahid, Roxana Coman, Qing Zhang
A 52-year-old Caucasian woman presented with progressive nausea and vomiting, weight loss, and burning epigastric and chest pain. Initial oesophagogastroduodenoscopy (OGD) with biopsies demonstrated gastritis in absence of Helicobacter pylori A gastric emptying study, CT scan with pancreatic protocol and a colonoscopy revealed no concerning findings. Calcium channel blockers and proton pump inhibitors offered little improvement. A high-resolution oesophageal impedance manometry was performed, which was significant for jackhammer oesophagus with maximum distal contractile index 11 052 mm Hg-s-cm...
May 12, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/23974310/mesotherapy-cosmetic-applications
#4
Jill Stachowski, Kayla Botts, Lesley Rine, Danielle Kato, Jennifer Pollock
Mesotherapy, which has been compared to the anti-wrinkle injection Botox, has only recently become popular in the United States for providing body contouring and spot weight loss. Most adverse reactions associated with mesotherapy are mild and transient, and supporters of the procedure consider it a safer alternative to liposuction. Mainly owing to the absence of safety and efficacy data pertaining to mesotherapy, liposuction is currently the only method for fat removal that is endorsed by the American Society of Plastic Surgeons ...
September 2006: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/23388417/reduced-gravitational-loading-does-not-account-for-the-skeletal-effect-of-botulinum-toxin-induced-muscle-inhibition-suggesting-a-direct-effect-of-muscle-on-bone
#5
Stuart J Warden, Matthew R Galley, Jeffrey S Richard, Lydia A George, Rachel C Dirks, Elizabeth A Guildenbecher, Ashley M Judd, Alexander G Robling, Robyn K Fuchs
Intramuscular injection of botulinum toxin (botox) into rodent hindlimbs has developed as a useful model for exploring muscle-bone interactions. Botox-induced muscle inhibition rapidly induces muscle atrophy and subsequent bone loss, with the latter hypothesized to result from reduced muscular loading of the skeleton. However, botox-induced muscle inhibition also reduces gravitational loading (as evident by reduced ground reaction forces during gait) which may account for its negative skeletal effects. The aim of this study was to investigate the skeletal effect of botox-induced muscle inhibition in cage control and tail suspended mice, with tail suspension being used to control for the reduced gravitational loading associated with botox...
May 2013: Bone
https://www.readbyqxmd.com/read/23246791/pth-1-34-but-not-strontium-ranelate-counteract-loss-of-trabecular-thickness-and-bone-strength-in-disuse-osteopenic-rats
#6
Annemarie Brüel, Jens Bay Vegger, Anders Christer Raffalt, Jens Enevold Thaulov Andersen, Jesper Skovhus Thomsen
PTH and strontium ranelate (SrR) have both been shown to reduce bone loss induced by immobilization. PTH is a potent bone anabolic agent, whereas SrR has been suggested to be an antiresorptive as well as a bone anabolic agent. The aim of the study was to investigate whether PTH, SrR, and PTH and SrR in combination could counteract immobilization-induced bone loss in a rat model. Immobilization was induced by injecting 4IU Botox (BTX) into the muscles of the right hind limb. Seventy-two female Wistar rats, 3-months-old, were divided into the following groups: Baseline, Controls, BTX, BTX+PTH, BTX+SrR, and BTX+PTH+SrR (n=12 in each group)...
March 2013: Bone
https://www.readbyqxmd.com/read/21930998/predictors-of-long-term-outcome-after-laparoscopic-esophagomyotomy-and-dor-fundoplication-for-achalasia
#7
Jonathan T Carter, Dennis Nguyen, Garrett R Roll, Sandi W Ma, Lawrence W Way
OBJECTIVE: To identify predictors of long-term outcome of laparoscopic Heller myotomy for achalasia, including predictors of heartburn and recurrent dysphagia, which occasionally develop postoperatively. DESIGN: Retrospective review using interviews of patients. SETTING: Academic university hospital. PATIENTS: One hundred sixty-five patients with achalasia who underwent a laparoscopic esophagomyotomy and Dor fundoplication...
September 2011: Archives of Surgery
https://www.readbyqxmd.com/read/17216576/the-use-of-the-internet-in-data-assimilation-in-rare-diseases
#8
Raymond Bedgood, Rafal Sadurski, Robert R Schade
The incidence and prevalence of achalasia is 0.6/100,000 people per year and 1/10,000, respectively. It is difficult then for one center to accumulate a large cohort of patients. One study (Gut 33:1011,1992) described the presenting symptoms in only 38 patients. To approach this problem differently, we used the internet to access a larger patient population. Using search engines at Google and Yahoo, Inc., we identified achalasia support groups. We examined the most populated support group (YSG) and assembled the exchanged messages into 4 categories: support, symptoms, treatment, and diagnosis...
February 2007: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/16416206/achalasia-in-a-patient-with-gastroesophageal-varices-problematic-treatment-decisions
#9
Hugo Pinillos, Peter Legnani, Thomas Schiano
The coexistence of achalasia and gastroesophageal varices has been reported sporadically in the English medical literature. We report the case of a 60-year-old Hispanic woman with cryptogenic cirrhosis who was referred for a liver transplant evaluation and subsequently developed progressive dysphagia to both solids and liquids as well as substernal chest pain and weight loss. Endoscopy revealed the presence of grade I esophageal varices and large fundic varices, as well as retained liquid and solid food in the distal esophagus...
January 2006: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/16197786/effect-on-gastric-emptying-and-weight-reduction-of-botulinum-toxin-a-injection-into-the-gastric-antral-layer-an-experimental-study-in-the-obese-rat-model
#10
Halil Coskun, Yasin Duran, Ece Dilege, Mehmet Mihmanli, Hulya Seymen, Mehmet Onur Demirkol
BACKGROUND: We investigated the effects of Botox-A on weight loss and gastric emptying in an experimental obese rat model. Although there is evidence of weight loss in normal-weight rats after Botox-A injection, there are no studies indicating the effect of Botox-A injection on weight loss and gastric emptying time in obese rats. METHODS: 37 female Wistar Albino rats were given high calorie diet for 90 days. They were separated into 3 groups. The first group (Botox group) consisted of 15 obese rats whose gastric antrum was injected with 20 U of Botulinum Toxin Type A...
September 2005: Obesity Surgery
https://www.readbyqxmd.com/read/16185943/botox-induced-muscle-paralysis-rapidly-degrades-bone
#11
Sarah E Warner, David A Sanford, Blair A Becker, Steven D Bain, Sundar Srinivasan, Ted S Gross
The means by which muscle function modulates bone homeostasis is poorly understood. To begin to address this issue, we have developed a novel murine model of unilateral transient hindlimb muscle paralysis using botulinum toxin A (Botox). Female C57BL/6 mice (16 weeks) received IM injections of either saline or Botox (n = 10 each) in both the quadriceps and calf muscles of the right hindleg. Gait dysfunction was assessed by multi-observer inventory, muscle alterations were determined by wet mass, and bone alterations were assessed by micro-CT imaging at the distal femur, proximal tibia, and tibia mid-diaphysis...
February 2006: Bone
https://www.readbyqxmd.com/read/12452392/a-review-of-achalasia-in-33-children
#12
Sunny Zaheed Hussain, Ronald Thomas, Vasundhara Tolia
We reviewed our experience in the diagnosis and management of esophageal achalasia in 33 children over a 25-year period at a single center by a retrospective chart review of all patients diagnosed with achalasia between December 1, 1975 and January 30, 2001. There were 33 cases ranging from 5 months to 16 years of age at the time of presentation (17 boys and 16 girls). Although dysphagia and vomiting were the commonest presenting symptoms, weight loss, chest pain, coughing, and recurrent pneumonia also occurred in many patients...
November 2002: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/11851739/the-effect-of-botulinum-toxin-type-a-and-a-variable-hip-abduction-orthosis-on-gross-motor-function-a-randomized-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
R N Boyd, F Dobson, J Parrott, S Love, J Oates, A Larson, G Burchall, P Chondros, J Carlin, G Nattrass, H K Graham
Hip displacement is the second most common deformity after equinus in children with cerebral palsy (CP), and may result in dislocation, pain, fixed deformity and loss of function. We studied the combined effects of intramuscular injections of botulinum toxin type A (BTX-A) to the adductors and hamstrings and a variable hip abduction orthosis (SWASH), on gross motor function, hip displacement and progression to surgery, in a randomized clinical trial. Thirty-nine children, with bilateral spastic cerebral palsy, and mean age 3 years + 2 months (range 1 year+7 months--4 years +10 months) entered the trial...
November 2001: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/10430676/laparoscopic-heller-s-myotomy-or-botulinum-toxin-injection-for-management-of-esophageal-achalasia-patient-choice-and-treatment-outcomes
#14
COMPARATIVE STUDY
C N Andrews, M Anvari, J Dobranowski
BACKGROUND: Esophageal achalasia is a rare disease in which degenerating parasympathetic innervation of the lower esophageal sphincter (LES) leads to unopposed sympathetic tone and failure to relax on deglutition, resulting in a range of symptoms for the patient, most notably dysphagia, chest pain, regurgitation, and weight loss. Laparoscopic Heller's esophagomyotomy (Lap-HM) and botulinum toxin (BoTox) injection into the LES are two recently described methods for treating achalasia. No comparison of laparoscopic Heller's myotomy and botulinum toxin has yet been presented...
August 1999: Surgical Endoscopy
https://www.readbyqxmd.com/read/9721068/botox-induced-prostatic-involution
#15
R Doggweiler, D H Zermann, M Ishigooka, R A Schmidt
BACKGROUND: A simple approach to induced prostatic atrophy was explored. Surgical denervation is known to produce profound atrophy of the rat prostate. Because Botulinum toxin type A (Botox) produces a long-term chemical denervation, the potential to induce atrophy of the rat prostate was explored. METHODS: Thirty rat prostates were injected with varying doses of Botox. Single and serial injections were used, and rats were subsequently sacrificed after either 1 or 4 weeks, respectively...
September 15, 1998: Prostate
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