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https://www.readbyqxmd.com/read/28931045/effect-of-extracytoplasmic-function-sigma-factors-on-autoaggregation-hemagglutination-and-cell-surface-properties-of-porphyromonas-gingivalis
#1
Kazutaka Fujise, Yuichiro Kikuchi, Eitoyo Kokubu, Kazuko Okamoto-Shibayama, Kazuyuki Ishihara
Porphyromonas gingivalis is a bacterium frequently isolated from chronic periodontal lesions and is involved in the development of chronic periodontitis. To colonize the gingival crevice, P. gingivalis has to adapt to environmental stresses. Microbial gene expression is regulated by transcription factors such as those in two-component systems and extracytoplasmic function (ECF) sigma factors. ECF sigma factors are involved in the regulation of environmental stress response genes; however, the roles of individual ECF sigma factors are largely unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28930556/osteoimmunology-the-nexus-between-bone-and-immune-system
#2
Hamid Y Dar, Zaffar Azam, Rajaneesh Anupam, Rajesh K Mondal, Rupesh K Srivastava
Osteoimmunology is an interdisciplinary research field which combines the existing fields of osteology (bone biology) and immunology under one umbrella. The observation that contributed enormously to the emergence of osteoimmunology as an independent field of investigation was the enhanced bone loss in various inflammatory bone diseases such as rheumatoid arthritis, osteoporosis and periodontitis. T helper cells (Th1, Th2, Treg and Th17) along with various other immune cells (B cells, DC, macrophages etc.) are actively involved in bone homeostasis...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929308/influence-of-obesity-on-experimental-periodontitis-in-rats-histopathological-histometric-and-immunohistochemical-study
#3
Elizangela Partata Zuza, Valdir Gouveia Garcia, Letícia Helena Theodoro, Edilson Ervolino, Luiz Fernando Veloso Favero, Mariéllen Longo, Fernando Salimon Ribeiro, Alex Tadeu Martins, Luís Carlos Spolidorio, José Antônio Sampaio Zuanon, Benedicto Egbert Corrêa de Toledo, Juliana Rico Pires
OBJECTIVES: This study assessed the influence of obesity on the progression of ligature-induced periodontitis in rats. MATERIALS AND METHODS: Forty-eight adult Wistar rats were randomly divided into two groups: the HL group (n = 24) was fed high-fat animal food to induce obesity, and the NL group (n = 24) was fed normolipidic animal food. Obesity was induced within a period of 120 days, and the induction of experimental periodontitis (EP) was subsequently performed for 30 days...
September 19, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28929053/thermoreversible-in-situ-gel-for-subgingival-delivery-of-simvastatin-for-treatment-of-periodontal-disease
#4
Swaminathan Rajendran, K Sathesh Kumar, S Ramesh, Suresh Ranga Rao
OBJECTIVE: The aim of this in vitro study was to formulate an in situ thermoreversible injectable gel with poloxamer (PM) and methylcellulose (MC) to deliver simvastatin (SMV) in a controlled manner. SUBJECTS AND METHODS: Preformulation studies (Fourier transform infrared and differential scanning calorimetry) to assess the interaction between SMV and MC and PM were performed before gel formulation. Keeping the concentration of SMV at 2.2%, the concentration of PM and MC was altered to formulate in situ thermosensitive gel at 37°C...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28928887/association-between-periodontal-disease-and-prostate-cancer-results-of-a-12-year-longitudinal-cohort-study-in-south-korea
#5
Jae-Hong Lee, Helen Hye-In Kweon, Jung-Kyu Choi, Young-Taek Kim, Seong-Ho Choi
The incidence of prostate cancer (PC) accompanying periodontal disease (PD) is anticipated to increase due to population aging. The aim of this study was to determine the association between PD and PC using data in the National Health Insurance Service-Health Examinee Cohort (NHIS-HEC). A random stratified sample of 187,934 South Koreans was collected from the NHIS database from 2002 to 2013. We assessed the relationship between PD and PC while adjusting for potential confounding factors (sex, age, household income, insurance status, residence area, hypertension, diabetes mellitus, cerebral infarction, angina pectoris, myocardial infarction, smoking status, alcohol intake, and regular exercise)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28928784/association-of-stress-salivary-cortisol-level-and-periodontitis-among-the-inmates-of-a-central-prison-in-kerala
#6
Angel Fenol, Susan Jebi, Sajitha Krishnan, Jayachandran Perayil, Rajesh Vyloppillil, Anuradha Bhaskar, Sai Megha Menon, Ashitha Mohandas
BACKGROUND: The aim of this cross-sectional study was to evaluate the association between stress, salivary cortisol, and periodontitis among the inmates of the central prison. MATERIALS AND METHODS: Seventy inmates were grouped depending on their pocket depth into Group A (pocket depth >4 mm and <6 mm), Group B (at least four sites with pocket depth ≥6 mm), and Group C (pocket depth ≤3 mm). The clinical parameters such as the oral hygiene index-simplified, gingival index, pocket depth, and the clinical attachment levels (CALs) were recorded...
July 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28927956/the-correlation-between-periodontal-health-status-and-suspectibility-to-infections-associated-with-craniomaxillofacial-osteosynthesis-plates
#7
Yahya Açil, Marie-Annett Heitzer, Aydin Gülses, Hendrik Naujokat, Rainer Podschun, Jörg Wiltfang, Christian Flörke
AIM: The aim of the present study was to demonstrate the possible relation between periodontal health status and infections associated with osteosynthesis materials (OMs) used in the oral and maxillofacial reconstruction. MATERIAL AND METHODS: The study group consisted of 32 individuals which were subdivided into two groups regarding their PSI scores. After the removal of the osteosynthesis plates, microbial colonization was assessed via microbiological cultivation, fluorescence microscopy and scanning electron microscopy...
August 24, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28927926/short-dental-implants-a-scoping-review-of-the-literature-for-patients-with-head-and-neck-cancer
#8
REVIEW
Faraj Edher, Caroline T Nguyen
STATEMENT OF PROBLEM: Dental implants can be essential in the rehabilitation of various cancer defects, but their ideal placement can be complicated by the limited dimensions of the available host bone. Surgical interventions developed to increase the amount of bone are not all predictable or successful and can sometimes be contraindicated. Short dental implants have been suggested as an alternative option in sites where longer implants are not possible. Whether they provide a successful treatment option is unclear...
September 16, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28925546/multidisciplinary-full-mouth-rehabilitation-with-soft-tissue-regeneration-in-the-esthetic-zone
#9
Anja Liebermann, Stefan Frei, Madalena Lucia Pinheiro Dias Engler, Otto Zuhr, Otto Prandtner, Daniel Edelhoff, Reza Saeidi Pour
OBJECTIVE: Oral rehabilitation often requires a multidisciplinary approach including restorative dentistry, prosthodontics, and periodontology to fulfill high esthetic and functional demands, frequently combined with changes in the vertical dimension. The presence of gingival recessions can be associated with numerous factors, such as brushing or preparation trauma and persistent inflammation of the gingiva due to inadequate marginal fit of restorations. Because gingival recessions can cause major esthetic and functional problems, obtaining stability of the gingival tissue around prosthetic restorations is of essential concern...
September 19, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28925508/the-cost-effectiveness-of-oral-health-interventions-a-systematic-review-of-cost-utility-analyses
#10
Ruvini M Hettiarachchi, Sanjeewa Kularatna, Martin J Downes, Joshua Byrnes, Jeroen Kroon, Ratilal Lalloo, Newell W Johnson, Paul A Scuffham
OBJECTIVES: To assess the usage of cost-utility analysis (CUA) in oral health interventions and to evaluate the methods used and the reporting quality of CUA in publications on oral health interventions. METHODS: A systematic review was performed on literature published between 2000 and 2016 where cost-utility analyses of oral health interventions were included. The reporting quality of these oral health CUAs was assessed against the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist...
September 19, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28924232/infection-of-microglia-with-porphyromonas-gingivalis-promotes-cell-migration-and-an-inflammatory-response-through-the-gingipain-mediated-activation-of-protease-activated-receptor-2-in-mice
#11
Yicong Liu, Zhou Wu, Yurika Nakanishi, Junjun Ni, Yoshinori Hayashi, Fumiko Takayama, Yanmin Zhou, Tomoko Kadawaki, Hiroshi Nakanishi
Despite a clear correlation between periodontitis and cognitive decline in Alzheimer's disease, the precise mechanism underlying the relationship remains unclear. The periodontal pathogen Porphyromonas gingivalis produces a unique class of cysteine proteinases termed gingipains that comprises Arg-gingipain (Rgp) and Lys-gingipain (Kgp). Rgp and Kgp are important in the bacterial mediated host cell responses and the subsequent intracellular signaling in infected cells. In the present study, we attempted to clarify the potential effects of Rgp and Kgp on the cellular activation of brain-resident microglia...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924229/variations-in-oral-microbiota-associated-with-oral-cancer
#12
Hongsen Zhao, Min Chu, Zhengwei Huang, Xi Yang, Shujun Ran, Bin Hu, Chenping Zhang, Jingping Liang
Individual bacteria and shifts in microbiome composition are associated with human disease, including cancer. To unravel the connections underlying oral bacterial dysbiosis and oral squamous cell carcinoma (OSCC), cancer lesion samples and anatomically matched normal samples were obtained from the same patients. We then profiled the bacteria within OSCC lesion surface samples at the species level using next-generation sequencing to comprehensively investigate bacterial community composition and functional genes in these samples...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924191/metabolic-crosstalk-regulates-porphyromonas-gingivalis-colonization-and-virulence-during-oral-polymicrobial-infection
#13
Masae Kuboniwa, John R Houser, Erik L Hendrickson, Qian Wang, Samar A Alghamdi, Akito Sakanaka, Daniel P Miller, Justin A Hutcherson, Tiansong Wang, David A C Beck, Marvin Whiteley, Atsuo Amano, Huizhi Wang, Edward M Marcotte, Murray Hackett, Richard J Lamont
Many human infections are polymicrobial in origin, and interactions among community inhabitants shape colonization patterns and pathogenic potential (1) . Periodontitis, which is the sixth most prevalent infectious disease worldwide (2) , ensues from the action of dysbiotic polymicrobial communities (3) . The keystone pathogen Porphyromonas gingivalis and the accessory pathogen Streptococcus gordonii interact to form communities in vitro and exhibit increased fitness in vivo (3,4) . The mechanistic basis of this polymicrobial synergy, however, has not been fully elucidated...
September 18, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28923364/tissue-specific-immunity-at-the-oral-mucosal-barrier
#14
REVIEW
Niki M Moutsopoulos, Joanne E Konkel
The oral mucosal barrier is constantly exposed to a plethora of triggers requiring immune control, including a diverse commensal microbiome, ongoing damage from mastication, and dietary and airborne antigens. However, how these tissue-specific cues participate in the training of immune responsiveness at this site is minimally understood. Moreover, the mechanisms mediating homeostatic immunity at this interface are not yet fully defined. Here we present basic aspects of the oral mucosal barrier and discuss local cues that may modulate and train local immune responsiveness...
September 8, 2017: Trends in Immunology
https://www.readbyqxmd.com/read/28922461/the-role-of-leptin-as-a-biomarker-in-the-relationship-between-periodontitis-and-chronic-migraine
#15
Yago Leira, Pablo Ameijeira, Clara Domínguez, Rogelio Leira, Juan Blanco
AIM: To evaluate the prevalence of periodontitis (CP) and its contribution to serum leptin levels in chronic migraine (CM). MATERIAL AND METHODS: In this case-control study, we included 150 subjects divided into healthy controls (n=58) and CM patients (n=92). Demographic, neurological, clinical data as well as full-mouth periodontal records were obtained. Serum leptin levels were measured by ELISA technique. RESULTS: Both the prevalence of CP and mean serum leptin levels were significantly higher in patients with CM in comparison to controls (57...
September 18, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28921659/ligature-induced-peri-implantitis-and-periodontitis-in-mice
#16
Sarah Hiyari, Ryan Wong, Aline Yaghsezian, Azadi Naghibi, Sotirios Tetradis, Paulo M Camargo, Flavia Q Pirih
AIM: Peri-implantitis (PI), inflammation around dental implants, shares characteristics with periodontitis (PD). However, PI is more difficult to control, treat, and detailed pathophysiology is unclear. We aimed to compare PI and PD progression utilizing a murine model. MATERIALS AND METHODS: Four-week-old male C57BL/6J mice had their left maxillary molars extracted. Implants were placed in healed extraction sockets and osseointegrated. Ligatures were tied around the implant and second molar...
September 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28921548/smoking-cessation-and-response-to-periodontal-treatment
#17
REVIEW
Foteini Alexandridi, Sotiria Tsantila, Eudoxie Pepelassi
Smoking has detrimental oral effects. The aim of this study was to review the literature related to the impact of smoking cessation on periodontal health, periodontal disease and periodontal treatment outcome as well as to review the smoking cessation strategies and the dentist's role in the smoking cessation effort. Smoking cessation seems to have a positive effect on the periodontium, to decrease the risk for incidence and progression of periodontitis and to lead to a non-significant trend for greater mean probing depth reductions after non-surgical treatment over a 12-month period...
September 16, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28920162/periodontal-screening-and-referral-behaviour-of-general-dental-practitioners-in-flanders
#18
E Meers, C Dekeyser, C Favril, W Teughels, M Quirynen, Isabelle Laleman
OBJECTIVES: The objective of this study was to investigate the screening and referral behaviour of Flemish dentists concerning periodontitis and more specific, the use of the Dutch Periodontal Screening Index (DPSI). MATERIALS AND METHODS: An online questionnaire was electronically distributed through the different professional dental societies. It consisted of two parts: the first aimed at describing the profile of the dentist. The second part inquired the screening method, when this was applied, periodontal risk factors and referral behaviour...
September 17, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28920140/frequency-location-and-association-with-dental-pathology-of-mucous-retention-cysts-in-the-maxillary-sinus-a-radiographic-study-using-cone-beam-computed-tomography-cbct
#19
Andy Wai Kan Yeung, Ray Tanaka, Pek-Lan Khong, Thomas von Arx, Michael M Bornstein
OBJECTIVES: The purpose of the present study was to evaluate the frequency, locations, and dimensions of mucous retention cysts of the maxillary sinus and analyze potential associated dental pathology. MATERIALS AND METHODS: A total of 156 cone beam computed tomography (CBCT) scans were included in the analysis, resulting in an evaluation of 310 maxillary sinuses. The presence of mucous retention cysts (MRC) manifesting as dome-shaped radiopacities in the sinus was diagnosed...
September 17, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28920109/papillon-lef%C3%A3-vre-syndrome-a-series-of-three-cases-in-the-same-family-and-a-literature-review
#20
Jasbir D Upadhyaya, Dustin Pfundheller, Mohammed N Islam, Indraneel Bhattacharyya
Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder that exhibits palmoplantar keratosis and early severe periodontitis. The oral disease affects both the primary and permanent dentitions leading to premature exfoliation of teeth. Various etiologic factors, such as genetic mutations, immunologic alterations, and bacteria have been implicated in PLS. Genetic mutations leading to the loss of function of cathepsin C (CTSC) gene, located on chromosome 11q14, is considered pivotal in this condition...
2017: Quintessence International
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