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Marina Garcia de Souza Borges, Adriane Mesquita de Medeiros, Stela Maris Aguiar Lemos
PURPOSE: Characterize the performance of outpatients regarding aspects of communication disorders according to the categories of the International Classification of Functioning, Disability and Health - Children and Youth Version (ICF-CY). METHODS: This is a descriptive, observational study based on a retrospective analysis of secondary data collected at a Speech-language Pathology outpatient clinic of the public health network, from records of patients aged 5-16 years, evaluated between 2010 and 2014...
August 13, 2018: CoDAS
Samira S Valvassori, Cenita Borges, Daniela V Bavaresco, Roger B Varela, Wilson R Resende, Bruna R Peterle, Camila O Arent, Josiane Budni, João Quevedo
OBJECTIVE: To evaluate the effects of Hypericum perforatum (hypericum) on cognitive behavior and neurotrophic factor levels in the brain of male and female rats. METHODS: Male and female Wistar rats were treated with hypericum or water during 28 days by gavage. The animals were then subjected to the open-field test, novel object recognition and step-down inhibitory avoidance test. Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-line derived neurotrophic factor (GDNF) levels were evaluated in the hippocampus and frontal cortex...
August 9, 2018: Revista Brasileira de Psiquiatria
Bruna Emanuelle Sanches Borges, Elza Baia de Brito, Hellen Thais Fuzii, Cláudia Simone Baltazar, Aline Barreto Sá, Camile Irene Mota da Silva, Gleyce de Fátima Silva Santos, Maria da Conceição Nascimento Pinheiro
Objective To investigate the relation between oxidative stress markers, human papillomavirus infection and cervical cancer precursor lesions. Methods The study comprised women aged 14 to 60 years living in communities located by Amazon rivers in the state of Pará (Itaituba, Limoeiro do Ajuru and Bragança, 126, 68 and 43 women respectively). Papanicolau smears and polymerase chain reaction tests for human papillomavirus DNA detection were performed. Blood samples were collected to test malondialdehyde, total and oxidized glutathione levels...
2018: Einstein
Floris F van den Brand, Carin M J van Nieuwkerk, Bart J Verwer, Ynto S de Boer, Nanne K H de Boer, Chris J J Mulder, Elisabeth Bloemena, Christine M Bakker, Jan M Vrolijk, Joost P H Drenth, Adriaan C I T L Tan, Frank Ter Borg, Martijn J Ter Borg, Sven J van den Hazel, Akin Inderson, Maarten E Tushuizen, Gerd Bouma
BACKGROUND: Azathioprine (AZA) and mercaptopurine (MP) are the cornerstone of steroid-sparing strategies in autoimmune hepatitis (AIH). Up to 20% of patients do not tolerate or respond to these regimens. AIM: To retrospectively evaluate the tolerability and efficacy of tioguanine (thioguanine) (TG) therapy in selected patients with AIH and AIH variant syndromes. METHODS: Records of 52 patients who received TG therapy were retrieved from nine hospitals in the Netherlands...
August 15, 2018: Alimentary Pharmacology & Therapeutics
G L Delogu, F Pintus, L Mayán, M J Matos, S Vilar, J Munín, J A Fontenla, G Hripcsak, F Borges, D Viña
Monoamine oxidase (MAO) is an enzyme responsible for metabolism of monoamine neurotransmitters which play an important role in brain development and function. This enzyme exists in two isoforms, and it has been demonstrated that MAO-B activity, but not MAO-A activity, increases with aging. MAO inhibitors show clinical value because besides the monoamine level regulation they reduce the formation of by-products of the MAO catalytic cycle, which are toxic to the brain. A series of 2-phenylbenzofuran derivatives was designed, synthesized and evaluated against hMAO-A and hMAO-B enzymes...
September 1, 2017: MedChemComm
João Paulo Mendes Tribst, Amanda Maria de Oliveira Dal Piva, Alexandre Luiz Souto Borges, Marco Antonio Bottino
BACKGROUND/AIMS: Mouthguards are dental devices able to soften the risks of facial trauma. However, the large variety of mouthguard types and thicknesses raises the question of each one is the most effective and beneficial for the athlete. The aim of this study was to evaluate stress distribution in the skull, teeth and jaw as a consequence of a direct impact. MATERIAL AND METHODS: Using modeling software, a human skull was modeled and a human jaw was created with all teeth inserted into the respective alveolus...
August 14, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Linda D Mellby, Andreas P Nyberg, Julia S Johansen, Christer Wingren, Børge G Nordestgaard, Stig E Bojesen, Breeana L Mitchell, Brett C Sheppard, Rosalie C Sears, Carl A K Borrebaeck
Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with a 5-year survival of < 10% because of diffuse symptoms leading to late-stage diagnosis. That survival could increase significantly if localized tumors could be detected early. Therefore, we used multiparametric analysis of blood samples to obtain a novel biomarker signature of early-stage PDAC. The signature was derived from a large patient cohort, including patients with well-defined early-stage (I and II) PDAC. This biomarker signature was validated subsequently in an independent patient cohort...
August 14, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Samila Neres de Oliveira, Isauremi Vieira de Assunção, Boniek Castillo Dutra Borges
PURPOSE: To evaluate (1) the efficacy of Ibuprofen and codeine + paracetamol to control immediate bleaching sensitivity caused by in-office tooth bleaching performed with 35% hydrogen peroxide, and (2) tooth shade change caused by 35% hydrogen peroxide. METHODS: In this randomized, controlled and double blind clinical trial, 60 volunteers were divided into three treatment groups: 400 mg placebo (PL)(n=20), 400 mg ibuprofen (IB)(n=20), or 30 mg codeine + 500 mg paracetamol (CP)(n=20)...
August 2018: American Journal of Dentistry
GuangMing Tan, Ari J Mintz, Bruce Mintz, Jorge C Borges, Mary Deborah Hines, Robert M Schainfeld, Michael R Jaff, Ido Weinberg
Amphetamine and its related derivatives and analogues (ADRA) are highly addictive central nervous system stimulants that are used commonly in the treatment of attention-deficit/hyperactivity disorder and narcolepsy. These medications are associated with many side effects but reports of peripheral arterial manifestations associated with ADRA usage are scarce. We retrospectively reviewed the records of 16 patients (median age 37 years (IQR 31-47), 13 females) referred to a single tertiary referral service while receiving ADRA...
August 14, 2018: Vascular Medicine
Carolina Dourado Amaral, Galileu Barbosa Costa, William Marciel de Souza, Pedro Augusto Alves, Iara Apolinário Borges, Aline Lavado Tolardo, Marília Farignoli Romeiro, Betânia Paiva Drumond, Jônatas Santos Abrahão, Erna Geessien Kroon, Adriano Pereira Paglia, Luiz Tadeu Moraes Figueiredo, Giliane de Souza Trindade
New World orthohantaviruses are emerging RNA viruses that cause hantavirus cardiopulmonary syndrome (HCPS). These viruses are a burden to public health around the world with a lethality rate of around 60%. In South America, rodents of Sigmodontinae subfamily are the main reservoirs of orthohantaviruses. We described a serosurvey for orthohantaviruses circulation in an apparently healthy human population and small mammals from rural areas in Central Minas Gerais State, Brazil. A total of 240 individuals and 50 small mammals (26 rodents belonging to 10 different species and 24 marsupials from 4 different species) were sampled during 2012-2013...
August 13, 2018: EcoHealth
Ardalan Shariat, Joshua A Cleland, Mahmoud Danaee, Reza Alizadeh, Bahram Sangelaji, Mehdi Kargarfard, Noureddin Nakhostin Ansari, Shamsul Bahri Mohd Tamrin
BACKGROUND: There are many potential training exercises for office workers in an attempt to prevent musculoskeletal disorders. However, to date a suitable tool to monitor the perceived exertion of those exercises does not exist. OBJECTIVE: The primary objective of this study was to examine the validity and reliability of the Borg CR-10 scale to monitor the perceived exertion of office exercise training. METHODS: The study involved 105 staff members employed in a government office with an age range from 25 to 50 years...
August 6, 2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
Jowanka Amorim, Marcos de Carvalho Borges, Alexandre Todorovic Fabro, Silvia Helena Taleb Contini, Mayara Valdevite, Ana Maria Soares Pereira, Fabio Carmona
ETHNOPHARMACOLOGICAL RELEVANCE: Erythrina mulungu Benth. ("mulungu", Fabaceae) is a Brazilian native species with ethnopharmacological use for respiratory diseases. However, the effects of E. mulungu on the respiratory were never studied. AIMS OF THE STUDY: To evaluate the effects of an ethanolic extract from flowers of E. mulungu in ovalbumin (OVA)-induced asthma in mice, and to study the mechanisms involved. MATERIALS AND METHODS: OVA-sensitized mice were intraperitoneally (i...
August 10, 2018: Journal of Ethnopharmacology
Bruno Antonio Ferreira, Simone Ramos Deconte, Francyelle Borges Rosa de Moura, Tatiana Carla Tomiosso, Patrícia Bianca Clissa, Silvia Passos Andrade, Fernanda de Assis Araújo
Jararhagin, a metalloprotease from Bothrops jararaca snake venom, is a toxin containing the metalloproteinase, disintegrin-like and cysteine-rich domains; it causes acute inflammation and damage to vascular tissue. However, the actions of these domains on key components of chronic inflammation have not been determined. Our aim was to investigate the effects of jararhagin (Jar), jararhagin-C (Jar-C) and o-phenantrolin-treated jararhagin (Jar-Phe), on inflammatory response, blood vessel formation and extracellular matrix deposition in the murine sponge model...
August 10, 2018: International Journal of Biological Macromolecules
João Augusto Vianna Goulart-Filho, Victor Angelo Martins Montalli, Fabrício Passador-Santos, Andresa Borges Soares, Ney Soares de Araújo, Vera Cavalcanti de Araújo
Considered as an aggressive counterpart of central ossifying fibroma (OF), juvenile ossifying fibroma (JOF) is a benign fibro-osseous neoplasm characterized by an unpredictable destructive behavior, elevated morbidity, mutilating treatment and high potential for local recurrences. The aim of this study is to compare the analysis for cell proliferation and vascular markers between JOF and OF. Cell proliferation index was measured by Ki-67 and Mcm-2 expression and microvessel density (MVD) was obtained by the immunoexpression of CD34/CD105...
August 4, 2018: Annals of Diagnostic Pathology
Márcia H Borges, Filipe Andrich, Pedro H Lemos, Thiago G Soares, Thiago N Menezes, Fabiana V Campos, Leandro X Neves, William Castro-Borges, Suely G Figueiredo
The biological activities observed upon envenomation by Scorpaena plumieri could be linked to both the venom and the skin mucus. Through a proteomic/functional approach we analyzed protein composition and biological activities of the venom and skin mucus. We identified 885 proteins: 722 in the Venomous Apparatus extracts (Sp-VAe) and 391 in the Skin Mucus extract (Sp-SMe), with 494 found exclusively in Sp-VAe, being named S. plumieri Venom Proteins (Sp-VP), while 228 were found in both extracts. The majority of the many proteins identified were not directly related to the biological activities reported here...
August 8, 2018: Journal of Proteomics
Hélito Volpato, Débora Botura Scariot, Edna Filipa Pais Soares, Andrey Petita Jacomini, Fernanda Andreia Rosa, Maria Helena Sarragiotto, Tânia Ueda-Nakamura, Adley Forti Rubira, Guilherme Miranda Pereira, Rui Manadas, Alcino J Leitão, Olga Borges, Celso Vataru Nakamura, Maria do Céu Sousa
The objective of this study was to encapsulate a synthetic compound, the 4-[(2E)-N'-(2,2'-bithienyl-5-methylene)hydra-zinecarbonyl]-6,7-dihydro-1-phenyl-1H-pyrazolo[3,4-d]pyridazin-7-one (T6) in glucan-rich particles mainly composed by the cell wall of Saccharomyces cerevisiae (GPs) and to study their individual and combined activity on Leishmania infantum. The possible mechanism of action of T6 was also investigated. Our results showed the activity of T6 compound in both promastigote (IC50  = 2.5 μg/mL) and intracellular amastigote (IC50  = 1...
August 7, 2018: International Journal of Biological Macromolecules
Peres Ramos Badial, Raffaella Bertoni Cavalcanti Teixeira, Diego José Zanzarini Delfiol, Ligia Souza Lima Silveira da Mota, Alexandre Secorun Borges
Overo lethal white foal syndrome (OLWFS) is a genetic disorder caused by a dinucleotide mutation in the endothelin receptor type B (EDNRB) gene leading to the death of affected foals shortly after birth. The use of rapid and reliable genetic testing is imperative for the early diagnosis of the mutation avoiding, therefore, either additional suffering or the production of affected animals. In the present study, we developed and validated a high-resolution melting (HRM) genotyping assay to detect the OLWFS causative mutation, and we also determined the frequency of heterozygotes among American Paint horses in Brazil...
August 7, 2018: Molecular and Cellular Probes
Philip M Nussenzweig, Luciano A Marraffini
Viruses have evolved inhibitors to counteract the CRISPR immune response, but they are not fully potent and need some time to be expressed after the beginning of infection. In this issue of Cell, Borges et al. and Landsberger et al. show that sequential infection gradually immunosuppresses the host to allow effective CRISPR inhibition.
August 9, 2018: Cell
L Damone, M Barbagallo, M Mastromarco, A Mengoni, L Cosentino, E Maugeri, S Heinitz, D Schumann, R Dressler, F Käppeler, N Colonna, P Finocchiaro, J Andrzejewski, J Perkowski, A Gawlik, O Aberle, S Altstadt, M Ayranov, L Audouin, M Bacak, J Balibrea-Correa, J Ballof, V Bécares, F Bečvář, C Beinrucker, G Bellia, A P Bernardes, E Berthoumieux, J Billowes, M J G Borge, D Bosnar, A Brown, M Brugger, M Busso, M Caamaño, F Calviño, M Calviani, D Cano-Ott, R Cardella, A Casanovas, D M Castelluccio, R Catherall, F Cerutti, Y H Chen, E Chiaveri, J G M Correia, G Cortés, M A Cortés-Giraldo, S Cristallo, M Diakaki, M Dietz, C Domingo-Pardo, A Dorsival, E Dupont, I Duran, B Fernandez-Dominguez, A Ferrari, P Ferreira, W Furman, S Ganesan, A García-Rios, S Gilardoni, T Glodariu, K Göbel, I F Gonçalves, E González-Romero, T D Goodacre, E Griesmayer, C Guerrero, F Gunsing, H Harada, T Heftrich, J Heyse, D G Jenkins, E Jericha, K Johnston, Y Kadi, A Kalamara, T Katabuchi, P Kavrigin, A Kimura, N Kivel, U Köster, M Kokkoris, M Krtička, D Kurtulgil, E Leal-Cidoncha, C Lederer-Woods, H Leeb, J Lerendegui-Marco, S Lo Meo, S J Lonsdale, R Losito, D Macina, J Marganiec, B Marsh, T Martínez, A Masi, C Massimi, P Mastinu, F Matteucci, A Mazzone, E Mendoza, P M Milazzo, F Mingrone, M Mirea, A Musumarra, A Negret, R Nolte, A Oprea, N Patronis, A Pavlik, L Piersanti, M Piscopo, A Plompen, I Porras, J Praena, J M Quesada, D Radeck, K Rajeev, T Rauscher, R Reifarth, A Riego-Perez, S Rothe, P Rout, C Rubbia, J Ryan, M Sabaté-Gilarte, A Saxena, J Schell, P Schillebeeckx, S Schmidt, P Sedyshev, C Seiffert, A G Smith, N V Sosnin, A Stamatopoulos, T Stora, G Tagliente, J L Tain, A Tarifeño-Saldivia, L Tassan-Got, A Tsinganis, S Valenta, G Vannini, V Variale, P Vaz, A Ventura, V Vlachoudis, R Vlastou, A Wallner, S Warren, M Weigand, C Weiß, C Wolf, P J Woods, T Wright, P Žugec
We report on the measurement of the ^{7}Be(n,p)^{7}Li cross section from thermal to approximately 325 keV neutron energy, performed in the high-flux experimental area (EAR2) of the n_TOF facility at CERN. This reaction plays a key role in the lithium yield of the big bang nucleosynthesis (BBN) for standard cosmology. The only two previous time-of-flight measurements performed on this reaction did not cover the energy window of interest for BBN, and they showed a large discrepancy between each other. The measurement was performed with a Si telescope and a high-purity sample produced by implantation of a ^{7}Be ion beam at the ISOLDE facility at CERN...
July 27, 2018: Physical Review Letters
Pierre Blévin, Scott A Shaffer, Paco Bustamante, Frédéric Angelier, Baptiste Picard, Dorte Herzke, Børge Moe, Geir Wing Gabrielsen, Jan Ove Bustnes, Olivier Chastel
In birds, incubation-related behaviors and brood patch formation are influenced by hormonal regulation like prolactin secretion. Brood patch provides efficient heat transfer between the incubating parent and the developing embryo in the egg. Importantly, several environmental contaminants are already known to have adverse effects on avian reproduction. However, relatively little is known about the effect of contaminants on incubation temperature (Tinc ) for wild birds. By using temperature thermistors placed into artificial eggs, we investigated whether the most contaminated parent birds are less able to provide appropriate egg warming and thus less committed in incubating their clutch...
August 10, 2018: Environmental Toxicology and Chemistry
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