Mariell Rivedal, Håvard Mikkelsen, Hans-Peter Marti, Lili Liu, Krzysztof Kiryluk, Thomas Knoop, Rune Bjørneklett, Yngvar Lunde Haaskjold, Jessica Furriol, Sabine Leh, Flavia Paunas, Janka Bábíčková, Andreas Scherer, Camille Serre, Oystein Eikrem, Philipp Strauss
Some patients diagnosed with benign IgA nephropathy (IgAN) develop a progressive clinical course, not predictable by known clinical or histopathological parameters. To assess if gene expression can differentiate between progressors and non-progressors with assumed benign IgAN, we tested microdissected glomeruli from archival kidney biopsy sections from adult patients with stable clinical remission (21 non-progressors) or from 15 patients that had undergone clinical progression within a 25-year time frame. Based on 1 240 differentially expressed genes from patients with suitable sequencing results, we identified eight IgAN progressor and nine non-progressor genes using a two-component classifier...
December 26, 2023: Kidney International