keyword
MENU ▼
Read by QxMD icon Read
search

apoL

keyword
https://www.readbyqxmd.com/read/30261216/development-and-evaluation-of-in-silico-prediction-model-for-drug-induced-respiratory-toxicity-by-using-na%C3%A3-ve-bayes-classifier-method
#1
Hui Zhang, Jin-Xiang Ma, Chun-Tao Liu, Ji-Xia Ren, Lan Ding
Respiratory toxicity is considered as main cause of drug withdrawal, which could seriously injure human health or even lead to death. The objective of this investigation was to develop an in silico prediction model of drug-induced respiratory toxicity by using naïve Bayes classifier. The genetic algorithm was used to select important molecular descriptors related to respiratory toxicity, and the ECFP_6 fingerprint descriptors were applied to the respiratory toxic/non-toxic fragments production. The established prediction model was validated by the internal 5-fold cross validation and external test set...
September 25, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30214199/layer-by-layer-dna-films-incorporating-highly-transfecting-bioreducible-poly-amido-amine-and-polyethylenimine-for-sequential-gene-delivery
#2
Lingxiao Xie, Xiong Ding, Rachel Budry, Guangzhao Mao
Background: The layer-by-layer (LbL) assembly method offers a molecular level control of the amount and spatial distribution of bioactive molecules. However, successful clinical translation of LbL film technology will most certainly require a better understanding and control of not only the film assembly process, but also film disassembly kinetics in physiologic conditions. Purpose: This work focuses on the understanding and control of degradation properties of LbL films for localized gene delivery...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29725595/stabilization-of-a-membrane-associated-amyloid-%C3%AE-oligomer-for-its-validation-in-alzheimer-s-disease
#3
Montserrat Serra-Batiste, James Tolchard, Fabrice Giusti, Manuela Zoonens, Natàlia Carulla
We have recently reported on the preparation of a membrane-associated β -barrel Pore-Forming Aβ42 Oligomer (β PFO Aβ 42 ). It corresponds to a stable and homogeneous Aβ42 oligomer that inserts into lipid bilayers as a well-defined pore and adopts a specific structure with characteristics of a β-barrel arrangement. As a follow-up of this work, we aim to establish β PFO Aβ 42 's relevance in Alzheimer's disease (AD). However, β PFO Aβ 42 is formed under dodecyl phosphocholine (DPC) micelle conditions-intended to mimic the hydrophobic environment of membranes-which are dynamic...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29678587/folding-and-stabilizing-membrane-proteins-in-amphipol-a8-35
#4
REVIEW
Christel Le Bon, Anaïs Marconnet, Sandrine Masscheleyn, Jean-Luc Popot, Manuela Zoonens
Membrane proteins (MPs) are important pharmacological targets because of their involvement in many essential cellular processes whose dysfunction can lead to a large variety of diseases. A detailed knowledge of the structure of MPs and the molecular mechanisms of their activity is essential to the design of new therapeutic agents. However, studying MPs in vitro is challenging, because it generally implies their overexpression under a functional form, followed by their extraction from membranes and purification...
September 1, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29348836/vitexin-confers-hsf-1-mediated-autophagic-cell-death-by-activating-jnk-and-apol1-in-colorectal-carcinoma-cells
#5
Monika Bhardwaj, Souren Paul, Rekha Jakhar, Imran Khan, Ji In Kang, Ho Min Kim, Jong Won Yun, Seon-Jin Lee, Hee Jun Cho, Hee Gu Lee, Sun Chul Kang
Heat shock transcription factor-1 (HSF-1) guards the cancerous cells proteome against the alterations in protein homeostasis generated by their hostile tumor microenvironment. Contrasting with the classical induction of heat shock proteins, the pro-oncogenic activities of HSF-1 remains to be explored. Therefore, cancer's fragile proteostatic pathway governed by HSF-1 could be a potential therapeutic target and novel biomarker by natural compounds. Vitexin, a natural flavonoid has been documented as a potent anti-tumor agent on various cell lines...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29246831/the-effect-of-normal-human-serum-on-the-mouse-trypanosome-trypanosoma-musculi-in-vitro-and-in-vivo
#6
Xuan Zhang, Xiao-Kun Hong, Su-Jin Li, De-Hua Lai, Geoff Hide, Zhao-Rong Lun, Yan-Zi Wen
Trypanosoma musculi, a common blood flagellate found in mice, is similar in morphology and life cycle to the rat trypanosome T. lewisi. Both species belong to the subgenus Herpetosoma, and as T. lewisi has recently been shown to be a zoonotic pathogen, there is concern that T. musculi could also be potentially infective to humans. To test this hypothesis, a well-established method, the normal human serum (NHS) incubation test, was carried out which distinguishes human and non-human infective trypanosomes...
January 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29226870/alzheimer-s-disease-progression-factors-influencing-cognitive-decline
#7
Camilla Ferrari, Gemma Lombardi, Cristina Polito, Giulia Lucidi, Silvia Bagnoli, Irene Piaceri, Benedetta Nacmias, Valentina Berti, Debora Rizzuto, Laura Fratiglioni, Sandro Sorbi
BACKGROUND: Alzheimer's disease (AD) patients present high variability in the rate of cognitive decline. Despite the wide knowledge on factors influencing dementia risk, little is known on what accounts for AD progression. Previous studies on this topic have mainly analyzed each factor separately without taking into account the interaction between genetic and non-genetic factors. OBJECTIVE: The aim of the present study is to evaluate the role of demographic, clinical, therapeutic, and genetic factors and their interaction on cognitive decline among newly diagnosed AD patients...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28924146/apols-with-low-ph-dependence-can-kill-all-african-trypanosomes
#8
Frédéric Fontaine, Laurence Lecordier, Gilles Vanwalleghem, Pierrick Uzureau, Nick Van Reet, Martina Fontaine, Patricia Tebabi, Benoit Vanhollebeke, Philippe Büscher, David Pérez-Morga, Etienne Pays
The primate-specific serum protein apolipoprotein L1 (APOL1) is the only secreted member of a family of cell death promoting proteins 1-4 . APOL1 kills the bloodstream parasite Trypanosoma brucei brucei, but not the human sleeping sickness agents T.b. rhodesiense and T.b. gambiense 3 . We considered the possibility that intracellular members of the APOL1 family, against which extracellular trypanosomes could not have evolved resistance, could kill pathogenic T. brucei subspecies. Here we show that recombinant APOL3 (rAPOL3) kills all African trypanosomes, including T...
November 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28795137/late-reoccurrence-of-collapsing-fsgs-after-transplantation-of-a-living-related-kidney-bearing-apol-1-risk-variants-without-disease-evident-in-donor-supports-the-second-hit-hypothesis
#9
Roberto S Kalil, Richard J Smith, Prerna Rastogi, Daniel A Katz, Christie P Thomas
No abstract text is available yet for this article.
August 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28699644/roles-of-apol1-g1-and-g2-variants-in-sickle-cell-disease-patients-kidney-is-the-main-target
#10
MULTICENTER STUDY
Raphaël Kormann, Anne-Sophie Jannot, Céline Narjoz, Jean-Antoine Ribeil, Sandra Manceau, Marianne Delville, Valentin Joste, Dominique Prié, Jacques Pouchot, Eric Thervet, Marie Courbebaisse, Jean-Benoît Arlet
In African-American patients with sickle cell disease (SCD), APOL1 G1 and G2 variants are associated with increased risk of sickle cell nephropathy (SCN). To determine the role of APOL1 variants in SCD patients living in Europe, we genotyped 152 SCD patients [aged 30·4 (24·3-36·4) years], mainly of Sub-Saharan African ancestry, for APOL1 G1 and G2 and for variants of four genes with kidney tropism (GSTM1, GSTT1, GSTP1, and HMOX1). Homozygous or double-heterozygous APOL G1 and G2 genotypes were strongly associated with end stage renal disease (P = 0·003) and worse Kidney Disease: Improving Global Outcomes stages (P = 0·001)...
October 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28232239/novel-na%C3%A3-ve-bayes-classification-models-for-predicting-the-chemical-ames-mutagenicity
#11
Hui Zhang, Yan-Li Kang, Yuan-Yuan Zhu, Kai-Xia Zhao, Jun-Yu Liang, Lan Ding, Teng-Guo Zhang, Ji Zhang
Prediction of drug candidates for mutagenicity is a regulatory requirement since mutagenic compounds could pose a toxic risk to humans. The aim of this investigation was to develop a novel prediction model of mutagenicity by using a naïve Bayes classifier. The established model was validated by the internal 5-fold cross validation and external test sets. For comparison, the recursive partitioning classifier prediction model was also established and other various reported prediction models of mutagenicity were collected...
June 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27753815/ssa-05-2-hypertension-and-kidney-complication-in-africa
#12
Solomon Kadiri
Hypertension prevalence rates in most urbanized areas of Africa range from 20-30%, with a recent systematic review reporting 16.2% for sub-Saharan Africa. These rates are lower than those in the West but the age standardized rates are higher than in other regions of the world. The attendant morbidity and mortality are disproportionately high. For example, failure of nocturnal dipping and microalbuminuria, predictive of vascular disease, occur relatively early in the course of hypertension and predispose to early vascular disease...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643378/ssa-05-2-hypertension-and-kidney-complication-in-africa
#13
Solomon Kadiri
Hypertension prevalence rates in most urbanized areas of Africa range from 20-30%, with a recent systematic review reporting 16.2% for sub-Saharan Africa. These rates are lower than those in the West but the age standardized rates are higher than in other regions of the world. The attendant morbidity and mortality are disproportionately high. For example, failure of nocturnal dipping and microalbuminuria, predictive of vascular disease, occur relatively early in the course of hypertension and predispose to early vascular disease...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27640368/analysis-of-apolipoprotein-genes-and-their-involvement-in-disease-response-of-channel-catfish-after-bacterial-infection
#14
Yujia Yang, Qiang Fu, Tao Zhou, Yun Li, Shikai Liu, Qifan Zeng, Xiaozhu Wang, Yulin Jin, Changxu Tian, Zhenkui Qin, Rex Dunham, Zhanjiang Liu
Apolipoproteins are protein component of plasma lipoproteins. They exert crucial roles in lipoprotein metabolism and serve as enzyme cofactors, receptor ligands, and lipid transfer carriers in mammals. In teleosts, apolipoproteins are also involved in diverse processes including embryonic and ontogenic development, liver and digestive system organogenesis, and innate immunity. In this study, we identified a set of 19 apolipoprotein genes in channel catfish (Ictalurus punctatus). Phylogenetic analysis and syntenic analysis were conducted to determine their identities and evolutionary relationships...
February 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27597133/novel-na%C3%A3-ve-bayes-classification-models-for-predicting-the-carcinogenicity-of-chemicals
#15
Hui Zhang, Zhi-Xing Cao, Meng Li, Yu-Zhi Li, Cheng Peng
The carcinogenicity prediction has become a significant issue for the pharmaceutical industry. The purpose of this investigation was to develop a novel prediction model of carcinogenicity of chemicals by using a naïve Bayes classifier. The established model was validated by the internal 5-fold cross validation and external test set. The naïve Bayes classifier gave an average overall prediction accuracy of 90 ± 0.8% for the training set and 68 ± 1.9% for the external test set. Moreover, five simple molecular descriptors (e...
November 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27559702/apolipoprotein-l-expression-correlates-with-neutrophil-cell-death-in-critically-ill-patients
#16
Israa Akl, Christophe Lelubre, Pierrick Uzureau, Michael Piagnerelli, Patrick Biston, Alexandre Rousseau, Bassam Badran, Hussein Fayyad-Kazan, Mohammad Ezedine, Jean-Louis Vincent, Karim Zouaoui Boudjeltia, Luc Vanhamme
Delayed neutrophil apoptosis has been demonstrated in sepsis and may contribute to organ damage. It has recently been proposed that apolipoprotein L (ApoL) may be involved in programmed cell death, but the expression and functions of ApoLs in leukocytes (especially neutrophils) during sepsis and other inflammatory conditions are currently unknown. In this prospective observational study in a 36-bed university hospital medicosurgical intensive care unit (ICU), we included 78 adult ICU patients with (n = 41) or without (n = 37) sepsis and 47 healthy volunteers...
January 2017: Shock
https://www.readbyqxmd.com/read/27509586/renal-histology-patterns-in-a-prospective-study-of-nephrology-clinics-in-lagos-nigeria
#17
Theophilus I Umeizudike, Jacob O Awobusuyi, Christiana O Amira, Taslim B Bello, Monica O Mabayoje, Adebowale O Adekoya, Olufemi O Adelowo, Mumuni A Amisu
BACKGROUND: The burden of chronic kidney disease (CKD) in Nigeria is quite alarming. The prevalence of CKD ranges from 11 - 23.5%. Hypertension and chronic glomerulonephritis (CGN) remain the two leading causes of CKD in Nigeria. The etiology of CKD in many of these patients remains unknown, as few biopsies are done. In order to demystify the various glomerular diseases that culminate in CGN, performing a kidney biopsy offers a ray of hope. Few studies on renal biopsies have emanated from Nigeria; this study, however, is unique as the histopathological analysis involves light, immunofluorescence, and electron microscopies...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27198486/apolipoproteins-l-control-cell-death-triggered-by-tlr3-trif-signaling-in-dendritic-cells
#18
Sophie Uzureau, Caroline Coquerelle, Corentin Vermeiren, Pierrick Uzureau, Annette Van Acker, Luc Pilotte, Daniel Monteyne, Valérie Acolty, Benoit Vanhollebeke, Benoît Van den Eynde, David Pérez-Morga, Muriel Moser, Etienne Pays
Apolipoproteins L (ApoLs) are Bcl-2-like proteins expressed under inflammatory conditions in myeloid and endothelial cells. We found that Toll-like receptor (TLR) stimuli, particularly the viral mimetic polyinosinic:polycytidylic acid (poly(I:C)), specifically induce ApoLs7/11 subfamilies in murine CD8α(+)  dendritic cells (DCs). This induction requires the TLR3/TRIF (where TRIF is TIR domain containing adapter-inducing interferon β) signaling pathway and is dependent on IFN-β in all ApoLs subfamilies except for ApoL7c...
August 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27157405/apolipoproteinl1-is-expressed-in-papillary-thyroid-carcinomas
#19
Mounia Chidiac, Mohammad Fayyad-Kazan, Jalil Daher, Philippe Poelvoorde, Isabelle Bar, Carine Maenhaut, Paul Delrée, Bassam Badran, Luc Vanhamme
The apolipoprotein L (apoL) family has not yet been ascribed any definite patho-physiological function although the conserved BH3 protein domain suggests a role in programmed cell death. As repression of the regular apoptotic program is considered a hallmark of tumor progression, we investigated apoL expression in cancer. We show that the levels of one member of the family, apolipoprotein L1 (apoL1) is higher in papillary thyroid carcinoma compared to normal tissue. A combination of qRTPCR, immunohistochemistry and in situ hybridization allowed us to ascribe this increase to endogenous overexpression in carcinoma cells...
July 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/26939285/anti-tumour-activity
#20
(no author information available yet)
Experimental tumours have great importance for the purposes of modelling where Dalton's ascites lymphoma (DAL) and Ehrlich ascites carcinoma (EAC) are the commonest. It appeared firstly as a spontaneous breast cancer in a female mouse and then Ehrlich and Apolant (Berlin KlinWshr 28:871-874, 1905) used it as an experimental tumour by transplanting tumour tissues subcutaneously from mouse to mouse. In 1932, Loewenthal and Jahn obtained the liquid form in the peritoneum of the mouse and named it as 'Ehrlich ascites carcinoma' due to the ascites liquid, together with the carcinoma cells...
2016: Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progrès des Recherches Pharmaceutiques
keyword
keyword
169685
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"