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https://www.readbyqxmd.com/read/30515820/evaluation-of-ovarian-cancer-risk-in-granulosa-cells-treated-with-steroid-depleted-endometriosis-serum-role-of-nf-%C3%AE%C2%BAb-rela-and-akt
#1
Samira Asghari, Amir Valizadeh Dizajeykan, Majid Ahmadi, Abolfazl Barzegari, Reza Rikhtegar, Sanam Dolati, Shahla Danaii, Sedigheh Abdollahi-Fard, Mohammad Nouri, Mahdi Mahdipour, Mehdi Yousefi
BACKGROUND: Despite at the beginning known as a benign disease, endometriosis is defined as a risk factor for developing ovarian carcinoma. The effect of endometriosis on ovarian malignancy is known but its role in granulosa cell tumor is still unclear. METHODS AND MATERIALS: In this study, serum samples were collected from patients with endometriosis and divided into whole and steroid-depleted groups. Desertification was performed according to the charcoal-dextran protocol and sera were added to the culture media of granulosa cells retrieved from tubal or male factor infertile women...
December 4, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30506766/sectioning-and-extensively-examining-the-fimbriated-end-see-fim-of-the-fallopian-tube-in-routine-practices-is-it-worth-the-effort
#2
Natthawadee Laokulrath, Malee Warnnissorn, Tuenjai Chuangsuwanich, Suchanan Hanamornroongruang
AIM: To determine the prevalence of fallopian tube high-grade serous carcinoma (HGSC) and to analyze the benefit of the sectioning and extensively examining the fimbriated end (SEE-FIM) protocol. METHODS: Fallopian tubes from 450 patients with risk-reducing salpingo-oophorectomy, or tumor of the ovary, endometrium, fallopian tube or peritoneum were examined using the SEE-FIM protocol. Microscopic tubal pathology and the number of paraffin blocks used were evaluated...
December 2, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/30503267/the-fallopian-tube-precursor-escape-and-narrowing-the-knowledge-gap-to-the-origins-of-high-grade-serous-carcinoma
#3
REVIEW
Thing Rinda Soong, Brooke E Howitt, Neil Horowitz, Marisa R Nucci, Christopher P Crum
Most ovarian carcinomas are high-grade serous carcinomas (HGSC) that contain TP53 mutations, present at advanced stage, and eventually become resistant to chemotherapy. The rapid evolution of this disease has been attributed to an origin in the distal fallopian tube, in the form of serous tubal intraepithelial carcinomas (STICs). This has led to a disease model where malignancy develops first in the tube and spreads to the peritoneum or regional lymph nodes. However, although most early or incidentally discovered HGSCs manifest in the tube with STICs, many advanced HGSCs are not accompanied by a malignancy in the fimbria...
November 29, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30486509/back-to-the-future-the-fallopian-tube-precursor-escape-and-a-dualistic-model-of-high-grade-serous-carcinogenesis
#4
T Rinda Soong, David L Kolin, Nathan J Teschan, Christopher P Crum
Beginning with the discovery of the BRCA -associated ovarian cancer susceptibility genes and subsequent detailed examination of risk-reducing salpingo-oophorectomy (RRSO) specimens, a new paradigm of ovarian carcinogenesis has unfolded with attention to the distal fallopian tube. The primary focus has been an early cancer or neoplasm in the fallopian tube which is seen in virtually all incidentally discovered high-grade serous cancers in asymptomatic women. This high-frequency of tubal involvement in early serous neoplasm (usually in the form of serous tubal intraepithelial carcinoma-STIC) has galvanized attention to this organ as a primary source of this disease...
November 28, 2018: Cancers
https://www.readbyqxmd.com/read/30424539/cell-origins-of-high-grade-serous-ovarian-cancer
#5
REVIEW
Jaeyeon Kim, Eun Young Park, Olga Kim, Jeanne M Schilder, Donna M Coffey, Chi-Heum Cho, Robert C Bast
High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is the most common and deadliest type of ovarian cancer. HGSC appears to arise from the ovary, fallopian tube, or peritoneum. As most HGSC cases present with widespread peritoneal metastases, it is often not clear where HGSC truly originates. Traditionally, the ovarian surface epithelium (OSE) was long believed to be the origin of HGSC. Since the late 1990s, the fallopian tube epithelium has emerged as a potential primary origin of HGSC...
November 12, 2018: Cancers
https://www.readbyqxmd.com/read/30390765/frontiers-in-the-pathology-and-pathogenesis-of-ovarian-cancer-cancer-precursors-and-precursor-escape
#6
REVIEW
Thing Rinda Soong, Daniela M Dinulescu, Wa Xian, Christopher P Crum
This article summarizes the pathogenesis of ovarian carcinoma, focusing on the paradox of high-grade serous carcinogenesis. The fallopian tube is the prime site of origin in early serous cancers. Because a subset of serous cancers is associated with early serous proliferations absent intramucosal carcinomas, "precursor escape" is emerging, whereby some advanced cancers trace their roots to early serous proliferations. This has parallels in the endometriosis model and opens up a novel mechanism by which advanced malignancy could emerge without an obvious tubal carcinoma...
December 2018: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/30375200/detection-of-tumor-cells-of-serous-tubal-intraepithelial-carcinoma-stic-in-cervical-smears-and-rapid-development-of-the-ovarian-involvement-a-case-report
#7
Masayuki Shintaku, Hiromi Taniguchi, Yoshihiro Yamamoto, Fumihiko Kono, Masahiro Sumitomo
Serous tubal intraepithelial carcinoma (STIC) has attracted attention as a precursor lesion of high-grade serous carcinoma (HGSC) of the ovary. We report the rare case of a woman in whom adenocarcinoma cells were detected in cervical smears and demonstrated to be derived from STIC in the fimbria. The patient was a 48-year-old woman, in whom cervical smears contained adenocarcinoma cells, but cervical conization did not reveal adenocarcinoma. Because the post-conization smears again demonstrated adenocarcinoma cells, hysterectomy with bilateral salpingectomy was performed 16 months after the first detection of adenocarcinoma cells in cervical smears...
October 30, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/30232083/fallopian-tube-lesions-in-women-at-high-risk-for-ovarian-cancer-a-multicenter-study
#8
Kala Visvanathan, Patricia Shaw, Betty J May, Asli Bahadirli-Talbott, Alpana Kaushiva, Harvey Risch, Steven Narod, Tian-Li Wang, Vinita Parkash, Russell Vang, Douglas A Levine, Robert Soslow, Robert Kurman, Ie-Ming Shih
The prognosis of women diagnosed with invasive high-grade serous ovarian carcinoma (HGSC) is poor. More information about serous tubal intraepithelial carcinoma (STIC) and serous tubal intraepithelial lesions (STIL), putative precursor lesions of HGSC, could inform prevention efforts. We conducted a multicenter study to identify risk/protective factors associated with STIC/STILs and characterize p53 signatures in the fallopian tube. The fallopian tubes and ovaries of 479 high-risk women ≥30 years of age who underwent bilateral risk-reducing salpingo-oophorectomy were reviewed for invasive cancer/STICs/STILs...
November 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/30197060/prognostic-implications-of-histological-tumor-regression-b%C3%A3-hm-s-score-in-patients-receiving-neoadjuvant-chemotherapy-for-high-grade-serous-tubal-ovarian-carcinoma
#9
Savithri Rajkumar, Alexander Polson, Rahul Nath, Geoffrey Lane, Ahmad Sayasneh, Adam Jakes, Shahina Begum, Gautam Mehra
OBJECTIVE: Primary objective of this study was to determine prognostic significance of Bohm's histopathological regression score in patients who received neoadjuvant chemotherapy (NACT) for treatment of high grade serous (HGS) tubal & ovarian carcinoma. METHODS: This was a retrospective cohort study of patients who received NACT between 2010 and 2015. The 3 point histopathological regression score of Böhm was used to classify chemotherapy response. Survival outcomes between the 3 different subgroups was analysed and compared with standard clinico-pathological variables using the Cox proportional hazards model and log-rank test...
November 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30108103/methylomic-analysis-of-ovarian-cancers-identifies-tumor-specific-alterations-readily-detectable-in-early-precursor-lesions
#10
Thomas R Pisanic, Leslie M Cope, Shiou-Fu Lin, Ting-Tai Yen, Pornpat Athamanolap, Ryoichi Asaka, Kentaro Nakayama, Amanda N Fader, Tza-Huei Wang, Ie-Ming Shih, Tian-Li Wang
Purpose: High-grade serous ovarian carcinoma (HGSOC) typically remains undiagnosed until advanced stages when peritoneal dissemination has already occurred. Here, we sought to identify HGSOC-specific alterations in DNA methylation and assess their potential to provide sensitive and specific detection of HGSOC at its earliest stages. Experimental Design: MethylationEPIC genome-wide methylation analysis was performed on a discovery cohort comprising 23 HGSOC, 37 non-HGSOC malignant, and 36 histologically unremarkable gynecologic tissue samples...
August 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30095490/characterization-of-primary-cilia-in-normal-fallopian-tube-epithelium-and-serous-tubal-intraepithelial-carcinoma
#11
Zakia A Abdelhamed, Thomas A Ryan, Martin Fuller, Camilla Coulson-Gilmer, Dina I Abdelmottaleb, Tian-Li Wang, Jen-Chun Kaun, Peiyi Wang, Richard Hutson, Nafisa Wilkinson, Sandra M Bell, Colin A Johnson
OBJECTIVES: The aim of this study was to investigate the distribution of primary cilia on secretory cells in normal fallopian tube (FT) and serous tubal intraepithelial carcinoma (STIC). METHODS: Fallopian tube tissue samples were obtained from 4 females undergoing prophylactic hysterectomies and 6 patients diagnosed with STIC. A mogp-TAg transgenic mouse STIC sample was also compared with a wild-type mouse FT sample. Serous tubal intraepithelial carcinoma was identified by hematoxylin and eosin staining and confirmed by positive Ki-67 and p53 immunohistochemical staining of tissue sections...
October 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/30087058/surgical-prevention-strategies-in-ovarian-cancer
#12
REVIEW
Adrianne Mallen, T Rinda Soong, Mary K Townsend, Robert M Wenham, Christopher P Crum, Shelley S Tworoger
Given the current lack of effective screening for ovarian cancer, surgical removal of at-risk tissue is the most successful strategy to decrease risk of cancer development. However, the optimal timing of surgery and tissues to remove, as well as the appropriate patients to undergo preventive procedures are poorly understood. In this review, we first discuss the origin and precursors of ovarian epithelial carcinomas, focusing on high-grade serous carcinomas and endometriosis-associated carcinomas, which cause the majority of the mortality and incidence of ovarian cancer...
October 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30043522/evidence-for-lineage-continuity-between-early-serous-proliferations-esps-in-the-fallopian-tube-and-disseminated-high-grade-serous-carcinomas
#13
Thing Rinda Soong, Brooke E Howitt, Alexander Miron, Neil S Horowitz, Frank Campbell, Colleen M Feltmate, Michael G Muto, Ross S Berkowitz, Marisa R Nucci, Wa Xian, Christopher P Crum
The distal Fallopian tube is a site of origin for many 'ovarian' high-grade serous carcinomas (HGSCs) with intraepithelial carcinomas (STICs) that share identical TP53 mutations with metastatic tumors. TP53 mutation-positive early serous proliferations (ESPs) comprise a spectrum including p53 signatures and serous tubal intraepithelial lesions (STILs) and are not considered malignant; however, ESPs are often the only abnormality found in Fallopian tubes of women with metastatic HGSC. The purpose of this study was to determine if a relationship exists between isolated ESPs and concurrent metastatic HGSCs in the absence of STIC...
July 25, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29962519/opportunistic-salpingectomy-at-the-time-of-benign-laparoscopic-hysterectomy-assessment-of-possible-complications-and-histopathological-p53-signatures
#14
Gautier Chene, Sarah Urvoas, Stéphanie Moret, Béatrice Nadaud, Annie Buenerd, Philippe Chabert, Georges Mellier, Gery Lamblin
Introduction: The aim of this study is to assess the prevalence of tubal histopathological abnormalities (serous tubal intraepithelial carcinoma STIC and p53 signatures) and the prevalence of perioperative and postoperative complications related to opportunistic laparoscopic salpingectomy in a low risk population. Materials and Methods: In this observational prospective cohort, prophylactic bilateral salpingectomy during benign laparoscopic hysterectomy was systematically performed in 100 consecutive women...
June 2018: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29952964/port-site-metastasis-as-a-primary-complication-following-diagnostic-laparoscopy-of-fallopian-tube-carcinoma-a-case-report
#15
Yan Chen, Chen Ling, Ce Bian
RATIONALE: Fallopian tube carcinoma is a rare female genital cancer with no specific clinical and surgical features. It is hardly diagnosed on imaging due to non-specific presentation. Laparoscopy has been recommended as the diagnostic procedure for the assessment of suspicious ovarian and adnexal masses. However, it has brought new complications like tumor recurrences at the trocar insertion sites, called port-site metastasis (PSM). PATIENT CONCERNS: A 65-year-old, postmenopausal woman presented to hospital with loss of appetite, Ultrasound showed ill-defined pelvic mass...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29945152/what-should-a-gynecologist-know-about-li-fraumeni-syndrome-lessons-from-a-patient-undergoing-hysterectomy-for-benign-indications
#16
Polina Advolodkina, Mark P Lachiewicz, Gabriela Oprea-Ilies, Bhagirath Majmudar, Alan N Gordon
Li-Fraumeni syndrome (LFS) is a rare highly penetrant cancer syndrome characterized by mutation in the TP53 tumor suppressor gene. Recent data suggest that this germline mutation is more frequent than once thought. While LFS has not been associated previously with pelvic serous carcinoma, gynecologic malignancies have been reported in this patient population. We present the case report of a 37-year-old patient with known LFS and a history of multiple cancers who underwent total abdominal hysterectomy for benign indications with incidental bilateral salpingo-oophorectomy...
2018: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29944973/ovarian-carcinomas-at-least-five-different-diseases-with-distinct-histological-features-and-molecular-genetics
#17
Jaime Prat, Emanuela D'Angelo, Iñigo Espinosa
Based on histopathology and molecular genetics, ovarian carcinomas are divided into five main types: high-grade serous (70%), endometrioid (10%), clear cell (10%), mucinous (3%), and low-grade serous (<5%) carcinomas. These tumors, which account for over 95% of cases, represent distinct diseases with different prognosis and treatments. TP53 mutations are identified in almost all (96%) high-grade serous carcinomas (HGSCs). Early p53 loss followed by BRCA loss leads to deficiency in homologous recombination (DHR) repair, which in turn triggers chromosomal instability and widespread somatic copy number changes...
June 23, 2018: Human Pathology
https://www.readbyqxmd.com/read/29909222/fallopian-tube-tumorigenesis-and-clinical-implications-for-ovarian-cancer-risk-reduction
#18
REVIEW
Allison A Gockley, Kevin M Elias
Ovarian cancer remains the leading cause of gynecologic cancer death among American women. Prevention is the only proven approach to reduce the incidence of the disease. Oral contraception, tubal ligation, and risk-reducing salpingo-oophorectomy (rrBSO) for high-risk groups are all established risk reduction strategies. This paradigm is changing as recent biologic studies suggest that many ovarian cancers, especially high-grade serous ovarian cancers, originate in the distal end of the fallopian tube rather than the ovarian surface epithelium...
September 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29901519/evidence-of-a-monoclonal-origin-for-bilateral-serous-tubal-intraepithelial-neoplasia
#19
Emily E Meserve, Kyle C Strickland, Alexander Miron, Thing R Soong, Frank Campbell, Brooke E Howitt, Christopher P Crum
Serous tubal intraepithelial carcinoma (STIC) is found in 10% to 60% of cases of tuboovarian high-grade serous carcinoma (HGSC) and is presumed to be the site of origin, linking many HGSCs to the fallopian tube. Bilateral STIC is present in ∼20% of cases. Because clonal Tp53 mutations are a defining feature of HGSC, including their associated STICs, we analyzed 4 cases of bilateral serous tubal intraepithelial neoplasia (STIN), including STIC and Tp53-mutated serous tubal intraepithelial lesions (STILs), associated with HGSC to determine whether they contained the same or different p53 mutations...
June 12, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29893323/the-clinical-impact-of-serous-tubal-intraepithelial-carcinoma-on-outcomes-of-patients-with-high-grade-serous-carcinoma-of-the-ovary-fallopian-tube-and-peritoneum
#20
Tayfun Toptas, Elif Pestereli, Tayup Simsek, Selen Bozkurt, Gulgun Erdogan, Seyda Karaveli
Aims: To investigate whether the presence of serous tubal intraepithelial carcinoma (STIC) is associated with clinical outcomes in a nonselected (unknown BRCA status) cohort of patients with a high-grade serous carcinoma (HGSC) of the ovary, fallopian tube, and peritoneum. Settings and Design: A prospective case-series with planned data collection. Subjects and Methods: The study was conducted in a total of 131 patients, who underwent primary cytoreductive surgery between 2007 and 2012...
April 2018: Journal of Cancer Research and Therapeutics
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