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Vaginal carcinoma

G Broggi, E Piombino, G Magro, G M Vecchio
Intestinal-type adenocarcinoma is a rare primary vaginal carcinoma and considerably more uncommon than metastatic lesions which represent the most frequent malignancy at this anatomic site. Among all malignant tumors, colorectal, breast and female genital tract carcinomas have the tendency to metastasize to the vagina. As morphologic and immunohistochemical features of intestinal-type adenocarcinoma occurring primarily in the vagina are not specific, clinical and radiologic information is crucial to exclude a metastatic lesion...
September 2018: Pathologica
Tiantian Han, Ying Jin, Yan Li, Yalan Bi, Lingya Pan
In the recent 20 years, primary vaginal adenosis is extremely rare and the data of clinical presentations, management, and outcome have not been studied systematically.In this retrospective study, women with vaginal adenosis between January 1997 and June 2017 were identified from the hospital's medical records. Data on patient age, history, symptoms, mass location, size, diagnosis, complications, treatment, and recurrence were analyzed by SPSS 20.0.Twenty women were histopathologically diagnosed as having vaginal adenosis (mean age, 37...
December 2018: Medicine (Baltimore)
Aharon Feldman, Sadaf Chaugle, Charlotte Burmeister, Adnan Munkarah, Mohamed A Elshaikh
OBJECTIVE: To compare survival endpoints between African American (AA) and non-AA (NAA) women with endometrial carcinoma (EC) stage I-II using a robust matching analysis. METHODS AND MATERIALS: Patients were matched by stage, grade, adjuvant management (surveillance, vaginal brachytherapy or pelvic radiation treatment), age, and year of hysterectomy. Recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) were calculated. RESULTS: A total of 758 patients were included...
December 12, 2018: Gynecologic and Obstetric Investigation
Gazal Jain, Sasidharanpillai Sabeena, Akhila Vasudeva, Anjali Mundkur, Srilatha Parampalli Srinivas, G Arunkumar, Pratap Kumar
Once the recommended 5-year recurrence-free follow-up is achieved for cervical cancers regular annual pelvic examination is mandatory. The main aim of presenting this short report is to emphasize the difficulties in the collection and interpretation of cytology samples from stenosed cervix or vault after pelvic irradiation. Radiotherapy can induce changes in the cellular morphology which may persist for many years. A 64-year old post-menopausal lady who had received radiation therapy 32 years back for cervical carcinoma stage IIb presented to the Gynecology outpatient department with vaginal spotting...
December 2018: Virusdisease
Elysia Donovan, Clare J Reade, Lua R Eiriksson, Gregory R Pond, Nikita Arora, Lorraine Elit, Sadaf Memon, Sachi Voruganti, Maltibehn Patel, Waldo Jimenez, Mazurka John, Iwa Kong
PURPOSE: Serous adenocarcinoma is a rare, aggressive histologic subtype of endometrial cancer with a high rate of recurrence and a poor prognosis. The optimal adjuvant treatment for early-stage patients is unclear. Our objective was to evaluate the outcomes of stage IA serous endometrial cancers only treated at a single institution and determine whether our current approach of chemotherapy plus vaginal brachytherapy (VBT) is sufficient. METHODS: A retrospective chart review of our institution's pathology database, including all cases of stage IA serous endometrial carcinoma from 2000-2014 was completed...
September 29, 2018: Curēus
Li Luo, Bing Luo, Ying Zheng, Heng Zhang, Jing Li, Neil Sidell
BACKGROUND: Endometrial carcinoma is the most common gynaecologic malignancy in the world and develops through preliminary stages of endometrial hyperplasia. Atypical endometrial hyperplasia suggests a significant pre-malignant state with frank progression to endometrial carcinoma, and tends to occur at a young age. Oral progestins have been used as conservative treatment in young women with atypical endometrial hyperplasia, but they are associated with poor tolerability and side effects that may limit their overall efficacy...
December 4, 2018: Cochrane Database of Systematic Reviews
Qiongrong Chen, Manxiang Wang, Zhigao Xu, Mingwei Wang, Su Jin, Sufang Tian, Shuyuan Xiao
Muir-Torre syndrome is a rare subtype of Lynch syndrome characterized by coincidence of skin neoplasm and visceral malignancies. Here, we report a case of this rare disease, whose diagnosis of the syndrome was first suspected by the pathologist. This was a 60-yr-old woman who presented with an axillary skin nodule, which was diagnosed as basal cell carcinoma. Further inquiry revealed that she was hospitalized for evaluation of a recurrent vaginal stump endometrial carcinoma. Histologic workup and immunohistochemistry for mismatch repair proteins of both the skin and vaginal tumor suggested the possibility of Muir-Torre syndrome...
December 3, 2018: International Journal of Gynecological Pathology
María Reynel, Yván Villegas, Helmut Kiene, Paul G Werthmann, Gunver S Kienle
RATIONALE: Carcinoma in situ (CIS) of the uterine cervix is a premalignant condition of squamous epithelium. The standard treatments are excision and ablation procedures; for women with positive margins, hysterectomy is recommended. PATIENT CONCERNS: A 47-year-old Peruvian woman with recurrent candidal vaginitis had been diagnosed with colpocervicitis and squamous metaplasia 8 years ago, which were not treated. DIAGNOSES: The patient was diagnosed with CIS after cervical conization procedure...
November 2018: Medicine (Baltimore)
Chao Zhang, Hongyan Zhang, Linqing Yang, Yunfei Wang, Xiaoyu Li, Jinfeng Guo, Jing Xu
RATIONALE: Primary squamous cell carcinoma of the endometrium (PSCCE) is a rare entity, and only sporadic cases have been reported in the literature since the 1st report in 1892. This report describes a case of a perimenopausal woman with PSCCE. PATIENT CONCERNS: A 47-year-old, human papilloma virus type 16-positive, perimenopausal woman was admitted to our hospital with irregular vaginal bleeding for 6 months and secondary anemia. DIAGNOSES: The patient was diagnosed with stage IIIc primary and moderately differentiated endometrial squamous cell carcinoma...
November 2018: Medicine (Baltimore)
Yanli Yan, Long Zhang, Li Tan, Xiaowei Ma, Yong Zhang, Shuai Shao, Jiaxin Liu, Chaofan Xue, Zongfang Li, Xiaozhi Zhang, Emmanuel Kwateng Drokow, Xiaoting Shi, Juan Ren
The management of ductal carcinoma in situ (DCIS) with endocrine therapy remains controversial. A meta-analysis was conducted to evaluate the role of endocrine therapy for DCIS with breast conserving surgery (BCS) and radiotherapy (RT). A total of 7 articles with randomized controlled trials were included. Five articles compared the effects of BCS and RT followed by tamoxifen (TAM) or not (BCS + RT + TAM vs BCS + RT) and 2 compared the effects of TAM and anastrozole (ANA). TAM obviously reduced the rates of recurrence of ipsilateral breast cancer (IBCR), recurrence of contralateral breast cancer (CBCR), recurrence of ipsilateral invasive breast cancer (IBCR-INV) and recurrence of contralateral DCIS (CBCR-DCIS), and increased the rate of event-free survival (EFS)...
November 29, 2018: Pathology Oncology Research: POR
Naveen Pradeep Kumar, Aswin Kumar, Puthuveettil G Jayaprakash, P Raghukumar, Francis V James
Purpose: The study aims to estimate the differences in vaginal surface, bladder, and rectal doses when adjuvant intracavitary brachytherapy is carried out with ovoids or with vaginal cylinders, in postoperative carcinoma endometrium and to assess the difference in variability in organs at risk (OAR) doses and thereby the reproducibility of application in subsequent sittings. Materials and Methods: Fifteen patients each received vaginal brachytherapy with ovoid and cylindrical applicators...
October 2018: Journal of Cancer Research and Therapeutics
Mariano Martini
Enrico Bottini (Stradella, Pavia, 7 September 1835 - Porto Maurizio, Sanremo, 11 March 1903) was a multifaceted surgeon, who left a strong mark in modern surgery, not only Italian but worldwide. A pupil of Porta and Ribeti, as well as the distinguished French surgeon and anatomist Charles-Marie-Édouard Chassaignac, he has dedicated himself throughout his career to various areas of medicine, ranging from bacteriology and anti-sepsis (use of a derivative of phenic acid) to urological surgery (the so-called "endo-urethral galva-cauterization", also called Bottini's operation, or Perineal incision according to Bottini)...
December 2018: Acta Medico-historica Adriatica: AMHA
Stefan A Koerber, Ben Seither, Alla Slynko, Matthias F Haefner, David Krug, Jakob Liermann, Sebastian Adeberg, Klaus Herfarth, Juergen Debus, Florian Sterzing
INTRODUCTION: We evaluated acute and chronic side effects of 3D conformal radiotherapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) in female patients with anal carcinoma and accessed correlations between dosimetric parameters and the considered toxicities. METHODS: For 70 women with anal cancer treated at our department, acute and chronic side effects and quality of life (QoL) were evaluated with questionnaires using the Common Terminology Criteria for Adverse Events (CTCAE v...
November 28, 2018: Tumori
Francesco Cuccia, Gianluca Mortellaro, Antonio Spera, Giovanna Evangelista, Antonio Lo Casto, Giuseppe Ferrera
Transitional cell carcinoma is a very rare histological subtype of endometrial cancer, with only 18 cases described in literature. Ovary represents the most common site where it accounts for 2% of all ovarian cancers. Due to the rarity of this disease, current management is controversial and includes various approaches, mostly described in the adjuvant setting, both radiotherapy and chemotherapy alone or in combination. Here, we report a case of a 65-year-old patient who underwent adjuvant vaginal brachytherapy for an endometrial transitional cell carcinoma...
October 2018: Journal of Contemporary Brachytherapy
Makoto Isono, Keiichi Ito, Shinsuke Hamada, Masahiro Takahashi, Hidenori Sasa, Hideyuki Shimazaki, Tomohiko Asano
Small cell carcinoma (SCC) of the urinary bladder is highly aggressive and portends a poor outcome. Herein, we report a patient with recurrent SCC of the urinary bladder who experienced an unusually long-term disease-free duration after radical cystectomy. The patient was a 60-year-old woman who had undergone transurethral resection followed by radical cystectomy for muscle-invasive bladder cancer (high-grade urothelial carcinoma with adenocarcinomatous differentiation) 6 years prior; the surgical specimen had a negative surgical margin...
2018: Case Reports in Urology
Li-Juan Zhao, Yuan-He Wang, Jing-Dong Zhang
INTRODUCTION: Rectal endometriosis is rare in women and imaging characteristics are similar with that of rectal cancer, which is one of the most common malignancies. PRESENTATION OF CASE: A 36 years old woman with a suspicious diagnosis of cervical carcinoma in a tertiary hospital visited our hospital, complaining about vaginal bleeding after copulation for six months, accompanying with constipation and diameter-thinning stool. Vaginal and cervical biopsy only showed chronic inflammation...
October 24, 2018: International Journal of Surgery Case Reports
Avni Gupta, Rebecca B Perkins, Gezzer Ortega, Sarah Feldman, Alessandro Villa
OBJECTIVES: The incidence of Human Papillomavirus (HPV) types 16 and 18 positive oropharyngeal squamous cell carcinomas is increasing. Oral HPV infection is acquired through oro-genital contact. We examined the association between barrier use during oro-genital sex and oral HPV 16/18 prevalence in HPV unvaccinated individuals. METHODS: A cross-sectional analysis of individuals aged 18-59 years with a history of oro-genital sex was conducted using National Health and Nutrition Assessment Survey (NHANES) from 2009 to 2014...
October 26, 2018: Oral Diseases
Elisabeth Smogeli, Milada Cvancarova, Yun Wang, Ben Davidson, Gunnar Kristensen, Kristina Lindemann
OBJECTIVES: Adjuvant treatment of high-risk endometrial cancer (EC) is still controversial. Several studies have tried to clarify the best treatment strategy, and guidelines have been made, but no study to date has shown a survival benefit for radiation over chemotherapy. We aimed to evaluate the outcome of high-risk EC patients treated with adjuvant chemotherapy only in a population where the routine administration of adjuvant radiotherapy was omitted. METHODS: This is a retrospective study including 230 EC patients with International Federation of Gynecology and Obstetrics stage I type II, stage Ib type I/G3, stage II, and IIIc treated at Oslo University Hospital between 2005 and 2012...
November 2018: International Journal of Gynecological Cancer
B G Wortman, C L Creutzberg, H Putter, I M Jürgenliemk-Schulz, J J Jobsen, L C H W Lutgens, E M van der Steen-Banasik, J W M Mens, A Slot, M C Stenfert Kroese, B van Triest, H W Nijman, E Stelloo, T Bosse, S M de Boer, W L J van Putten, V T H B M Smit, R A Nout
BACKGROUND: PORTEC-2 was a randomised trial for women with high-intermediate risk (HIR) endometrial cancer, comparing pelvic external beam radiotherapy (EBRT) with vaginal brachytherapy (VBT). We evaluated long-term outcomes combined with the results of pathology review and molecular analysis. METHODS: 427 women with HIR endometrial cancer were randomised between 2002-2006 to VBT or EBRT. Primary endpoint was vaginal recurrence (VR). Pathology review was done in 97...
October 25, 2018: British Journal of Cancer
Leszek Gottwald, Małgorzata Moszyńska-Zielińska, Leszek Żytko, Adam Tomalczyk, Karolina Loga, Jacek Fijuth
No abstract text is available yet for this article.
October 23, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
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