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https://www.readbyqxmd.com/read/30318573/simple-vaginal-trachelectomy-for-early-stage-cervical-cancer-a-tertiary-cancer-center-experience
#1
Fuat Demirkiran, Ilker Kahramanoglu, Tugan Bese, Hasan Turan, Elif Meseci, Macit Arvas
OBJECTIVES: Less radical fertility sparing procedures have been introduced to reduce morbidity and adverse obstetric outcome in cervical cancer. Our objective was to describe oncological and obstetric outcomes of women with early-stage cervical cancer who underwent a simple vaginal trachelectomy (SVT). MATERIAL AND METHODS: From 01/2013 to 05/2017, 14 women underwent SVT preceded by laparoscopic pelvic lymph node dissection. RESULTS: Patients' median age was 32 years and all of them were nulliparous...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/30315273/targeted-next-generation-sequencing-of-endometrial-cancer-and-matched-circulating-tumor-dna-identification-of-plasma-based-tumor-associated-mutations-in-early-stage-patients
#2
Ana M Bolivar, Rajyalakshmi Luthra, Meenakshi Mehrotra, Wei Chen, Bedia A Barkoh, Peter Hu, Wei Zhang, Russell R Broaddus
There is currently no blood-based marker in routine use for endometrial cancer patients. Such a marker could potentially be used for early detection, but it could also help to track tumor recurrence following hysterectomy. This is important, as extra-vaginal recurrence of endometrial endometrioid adenocarcinoma is usually incurable. This proof-of-principle study was designed to determine if tumor-associated mutations could be detected in cell-free DNA from the peripheral blood of early and late stage endometrial endometrioid carcinoma patients...
October 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/30303166/extensive-trophoblastic-differentiation-in-case-of-an-endometrial-carcinoma
#3
Surekha Yadav, Nishant Sagar, Varuna Mallya, Sharmana Mandal, Nita Khurana, Sangeeta Gupta
Trophoblastic differentiation of endometrial carcinoma is extremely rare, till date 18 cases reports are there in the literature. A 68-year-old postmenopausal female presented with abnormal vaginal bleeding. Histopathologically, there were areas of serous carcinoma with trophoblastic differentiation (~90%). On immunohistochemistry, the trophoblastic component was positive for β-human chorionic gonadotropin (hCG), HPL and EMA. IHC confirmed the diagnosis of serous carcinoma with trophoblastic differentiation...
October 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/30286364/melf-pattern-of-myometrial-invasion-and-role-in-possible-endometrial-cancer-diagnostic-pathway-a-systematic-review-of-the-literature
#4
REVIEW
Anastasia Prodromidou, George Vorgias, Konstantinos Bakogiannis, Nikolaos Kalinoglou, Christos Iavazzo
Microcystic, elongated, fragmented (MELF) pattern of myometrial invasion has been proposed as a prognostic marker in patients with endometrial carcinoma (EC). Its prognostic and predictive effect still remains elusive. The aim of the present study is to accumulate the current knowledge on the role of MELF pattern in the prognosis and survival of patients with EC. Medline, Scopus, Google Scholar, and Clinicaltrials.gov databases were searched for articles published up to May 2018, along with the references of all articles...
September 25, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/30250586/a-study-of-the-application-of-tap-combined-with-transvaginal-ultrasound-in-the-diagnosis-of-early-stage-endometrial-cancer
#5
Anjun Ma, Dianxia Fan, Fangli Yan
The aim of the study was to investigate the application of tumor abnormal protein (TAP) combined with transvaginal ultrasound in the diagnosis of early-stage endometrial cancer. A total of 248 patients with suspected endometrial cancer who were admitted to the Gynecology Department of the Second People's Hospital of Liaocheng from September 2013 to September 2015 were selected and randomly divided into the control (n=124) and the observation group (n=124). The control group received conventional ultrasound examination, while the observation, underwent TAP combined with conventional ultrasound examination...
October 2018: Oncology Letters
https://www.readbyqxmd.com/read/30248810/letter-to-the-editor-regarding-perineural-spread-along-spinal-and-obturator-nerves-in-primary-vaginal-carcinoma-a-case-report
#6
LETTER
Tomas Marek, Stepan Capek, Kimberly K Amrami, Robert J Spinner
No abstract text is available yet for this article.
October 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30215140/recurrent-urinary-tract-infections-in-females-and-the-overlap-with-overactive-bladder
#7
REVIEW
Farnoosh Nik-Ahd, A Lenore Ackerman, Jennifer Anger
PURPOSE OF REVIEW: There are an estimated 33 million men and women with overactive bladder (OAB) in the USA. Despite the prevalence of OAB, it remains a frequently misdiagnosed condition. OAB has shared symptomatology with other common urologic conditions, namely recurrent urinary tract infections (UTIs). Here, we will review key distinguishing features of OAB that aid in establishing an accurate diagnosis and recent advances in OAB management. RECENT FINDINGS: Recent studies have shown that among women presenting with lower urinary tract symptoms, the majority were diagnosed with UTIs and treated without performing a urine culture as routine care...
September 13, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/30191540/recurrent-small-cell-carcinoma-of-the-uterine-cervix-responding-to-combined-therapy-with-paclitaxel-cisplatin-and-bevacizumab-a-case-report
#8
Takeshi Hirasawa, Hiroshi Kajiwara, Hiroko Machida, Tetsuji Iida, Masae Ikeda, Masako Shida, Mikio Mikami
We report a patient with recurrent refractory small cell carcinoma of the uterine cervix, in whom combined therapy with paclitaxel, cisplatin, and bevacizumab (TP+Bev) was effective. Small cell cervical carcinoma is a rare malignancy and its outcome is reported to be poor. The patient was a 45-year-old woman who visited a local hospital with the chief complaint of irregular vaginal bleeding and was referred to our department. The results of a smear test and examination of a tissue biopsy specimen suggested small cell carcinoma...
September 20, 2018: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/30187220/extended-duration-of-dilator-use-beyond-1-year-may-reduce-vaginal-stenosis-after-intravaginal-high-dose-rate-brachytherapy
#9
John M Stahl, Jack M Qian, Christopher J Tien, David J Carlson, Zhe Chen, Elena S Ratner, Henry S Park, Shari Damast
BACKGROUND: Vaginal dilators (VD) are recommended following vaginal or pelvic radiotherapy for patients with endometrial carcinoma (EC) to prevent vaginal stenosis (VS). The time course of VS is not fully understood and the optimal duration of VD use is unknown. METHODS: We reviewed 243 stage IA-II EC patients who received adjuvant brachytherapy (BT) at an academic tertiary referral center. Patients were instructed to use their VD three times per week for at least 1-year duration...
September 5, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30183588/metastatic-breast-cancer-to-the-cervix-presenting-with-abnormal-vaginal-bleeding-during-chemotherapy-a-case-report-and-literature-review
#10
A Saad Abdalla, Anita Lazarevska, Mohammed Murwan Omer, Elizabeth Tan, Amira Asaad, Sharlini Sathananthan
The most common sites of invasive breast cancer metastasis are the lungs, liver, bones and brain. Less frequent sites include the gastrointestinal tract, pancreas, spleen, thyroid, adrenals, kidneys, heart and female genital tract. The uterus is reported as a rare site for metastasis, and even more so for an isolated metastasis. Other sites of extra-genital sources for uterine metastases include the colon, stomach, pancreas, gallbladder, lung, cutaneous melanoma, urinary bladder and thyroid. The rarity of breast cancer metastasis to the uterine cervix could be explained by the fact that the cervix has a small blood supply and an afferent lymph drainage system alone...
July 2018: Chirurgia
https://www.readbyqxmd.com/read/30173944/a-novel-case-of-endometrial-dedifferentiated-adenocarcinoma-associated-with-mlh1-promotor-hypermethylation-and-microsatellite-instability
#11
Xinying Liu, Xiaodan Liu, Xiaoqiang Wang, Rui Wu, Kuangen Zhang, Beiying Liu, Qichen Liu, Yakun Shao, Ran Tang, Jiangfeng You, Fei Pei
Endometrial dedifferentiated carcinoma is a rare, malignant tumor whose molecular alterations have not been clarified yet. We report a novel case of a 61-year old woman who presented with irregular vaginal bleeding after menopause and a 3 cm uterus mass. Histology revealed endometrial dedifferentiated adenocarcinoma, a rare subtype comprised of undifferentiated adenocarcinoma. The patient still survived 1 year after surgery without chemotherapy and radiotherapy. Immunohistochemistry revealed loss of MLH1/PMS2 expression and retained MSH2/MSH6 expression...
August 20, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/30153505/platelet-to-lymphocyte-and-neutrophil-to-lymphocyte-ratio-as-predictive-indices-of-endometrial-carcinoma-findings-from-a-retrospective-series-of-patients-and-meta-analysis
#12
Vasilios Pergialiotis, Maria Oikonomou, Vasileia Damaskou, Dimitrios Kalantzis, Charalampos Chrelias, Argirios E Tsantes, Ioannis Panayiotides
BACKGROUND: The purpose of the present study is to present new data concerning the diagnostic efficacy of neutrophil to lymphocyte (NLR) and platelet to lymphocyte (PLR) ratios in detecting endometrial carcinoma and to summarize the existing knowledge by accumulating all the available data in the existing literature. MATERIALS AND METHODS: We retrospectively identified patients with evidence of endometrial pathology (vaginal bleeding or increased endometrial thickness) that undergone dilatation and curettage...
August 25, 2018: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/30149185/the-utility-of-artificial-neural-networks-and-classification-and-regression-trees-for-the-prediction-of-endometrial-cancer-in-postmenopausal-women
#13
V Pergialiotis, A Pouliakis, C Parthenis, V Damaskou, C Chrelias, N Papantoniou, I Panayiotides
OBJECTIVE: Artificial neural networks (ANNs) and classification and regression trees (CARTs) have been previously used for the prediction of cancer in several fields. In our study, we aim to investigate the diagnostic accuracy of three different methodologies (i.e. logistic regression, ANNs and CARTs) for the prediction of endometrial cancer in postmenopausal women with vaginal bleeding or endometrial thickness ≥5 mm, as determined by ultrasound examination. STUDY DESIGN: We conducted a retrospective case-control study based on data from analysis of pathology reports of curettage specimens in postmenopausal women...
August 24, 2018: Public Health
https://www.readbyqxmd.com/read/30148742/a-comparison-of-gata3-ttf1-cd10-and-calretinin-in-identifying-mesonephric-and-mesonephric-like-carcinomas-of-the-gynecologic-tract
#14
Jennifer Pors, Angela Cheng, Joyce M Leo, Mary A Kinloch, Blake Gilks, Lynn Hoang
Mesonephric carcinomas of the gynecologic tract are neoplasms that are often under-recognized due to their varied morphologic appearances. Recently, GATA3 and TTF1 have been reported to be useful immunohistochemical markers for distinguishing mesonephric carcinomas from its morphologic mimics. Herein, we compared the performance of GATA3 and TTF1 to the traditional markers used for mesonephric carcinomas, CD10 and calretinin. We studied 694 cases: 8 mesonephric carcinomas (7 cervical [includes 3 mesonephric carcinosarcomas], 1 vaginal), 5 mesonephric-like carcinomas (4 uterine corpus, 1 ovarian), 585 endometrial adenocarcinomas, and 96 cervical adenocarcinomas...
August 24, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30148199/cervical-cancer-complicating-pelvic-organ-prolapse-and-use-of-a-pessary-to-restore-anatomy-for-optimal-radiation-a-case-report
#15
Josette C Dawkins, Gregory K Lewis, Eugene P Toy
Cervical cancer is the most common gynecologic malignancy worldwide and the third most common gynecologic cancer in the USA. Improved screening methods such as liquid-based cytology accompanied by Human Papilloma Virus (HPV) co-testing have contributed to a declining incidence of cervical cancer. There are approximately 13,000 new cases per year in the United States, accounting for 4200 deaths (Siegel et al., 2011). Pelvic organ prolapse increases with age, obesity and parity. In the absence of bothersome urinary, gastrointestinal or pressure symptoms, patients may choose conservative management options...
November 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/30139838/definitive-radiotherapy-in-invasive-vaginal-carcinoma-a-systematic-review
#16
REVIEW
Sara Guerri, Anna M Perrone, Milly Buwenge, Martina Ferioli, Gabriella Macchia, Luca Tagliaferri, Gabriella Ferrandina, Andrea Galuppi, Angela D Andrulli, Rezarta Frakulli, Silvia Cammelli, Alessandra Arcelli, Pierandrea De Iaco, Alessio G Morganti
AIM: This study systematically reviews the recent literature on the role of definitive radiotherapy (RT) in the management of vaginal cancer (VC) and presents comprehensive data on clinical outcomes and toxicity. METHODS: The authors performed a literature search using PubMed (2007-2016) to identify all prospective and retrospective studies that have been published on RT in invasive VC. RESULTS: Of the 199 identified studies, 13 met the inclusion criteria...
August 23, 2018: Oncologist
https://www.readbyqxmd.com/read/30138307/trends-in-human-papillomavirus-associated-cancers-united-states-1999-2015
#17
Elizabeth A Van Dyne, S Jane Henley, Mona Saraiya, Cheryll C Thomas, Lauri E Markowitz, Vicki B Benard
Human papillomavirus (HPV) is a known cause of cervical cancer, as well as some oropharyngeal, vulvar, vaginal, penile, and anal cancers. To assess trends, characterized by average annual percent change (AAPC), in HPV-associated cancer incidence during 1999-2015, CDC analyzed data from cancer registries covering 97.8% of the U.S. POPULATION: A total of 30,115 new cases of HPV-associated cancers were reported in 1999 and 43,371 in 2015. During 1999-2015, cervical cancer rates decreased 1...
August 24, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/30133069/long-term-survival-of-a-patient-with-malignant-transformation-of-extragonadal-endometriosis-treated-solely-with-chemotherapy-a-case-report
#18
Eiji Kondo, Shintaro Maki, Masafumi Nii, Kenta Yoshida, Tsutomu Tabata, Tomoaki Ikeda
A 52-year-old woman presented to our hospital complaining of genital bleeding and was found to have a 50-mm vaginal tumor that involved the bladder, rectum, and small bowel and extended to the left pelvic side wall. Her history included a bilateral salpingo-oophorectomy and a total abdominal hysterectomy for fibroids and endometriosis. She had been prescribed estrogen replacement therapy (1.25 mg/day) following the second surgery and continued it for 8 years. The pathology of the vaginal biopsy showed endometrioid adenocarcinoma...
August 21, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/30120545/human-papillomaviruses-in-western-africa-prevalences-and-risk-factors-in-burkina-faso
#19
Hatzipanagiotou Maria, Holzinger Dana, Millogo Françoise, Pawlita Michael, Wacker Jürgen
PURPOSE: Cervical cancer is the most common cancer in women in low income countries. Certain oncogenic types of human papillomaviruses are causally associated with the cervical cancer. To ensure effective primary prevention through the introduction of a national vaccination program in Burkina Faso, information about the disease burden of HPV infection in the country is of great importance. METHODS: In the present work the prevalence of 54 different HPV types and 18 other sexually transmitted infection as well as the predominant risk factors for the development of cervical cancer were investigated in Ouagadougou...
October 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/30104006/comparative-assessment-of-late-toxicity-in-patients-of-carcinoma-cervix-treated-by-radiotherapy-versus-chemo-radiotherapy-minimum-5-years-follow-up
#20
Shagun Misra, Punita Lal, Saibish Kumar Ep, Neeraj Rastogi, Anu Tiwari, Shalini Singh, K J Maria Das, Shaleen Kumar
BACKGROUND: A randomised trial was carried out comparing chemo-radiation (CTRT) vs. radiotherapy (RT) in patients of carcinoma cervix and showed similar rates of pelvic disease control, disease free survival and overall survival. Late toxicity is presented. METHODS: Between December 2000 and July 2006, 180 patients of carcinoma cervix were randomly assigned to RT + weekly cisplatin (n = 94) or RT alone (n = 86). Late toxicity was prospectively scored using RTOG criteria in 156 evaluable patients, 79 and 77 respectively and is presented as crude incidence for rectum, bladder, small intestine, vagina, skin and bone and also as actuarial incidence for rectum and bladder...
2018: Cancer treatment and research communications
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