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https://www.readbyqxmd.com/read/30078506/molecular-integrated-risk-profile-to-determine-adjuvant-radiotherapy-in-endometrial-cancer-evaluation-of-the-pilot-phase-of-the-portec-4a-trial
#1
B G Wortman, T Bosse, R A Nout, L C H W Lutgens, E M van der Steen-Banasik, H Westerveld, H van den Berg, A Slot, K A J De Winter, K W Verhoeven-Adema, V T H B M Smit, C L Creutzberg
OBJECTIVE: The Post-Operative Radiation Therapy in Endometrial Carcinoma (PORTEC)-4a trial is a randomized trial for women with high-intermediate risk endometrial cancer (EC), comparing individualized adjuvant treatment based on a molecular-integrated risk profile to standard adjuvant treatment; vaginal brachytherapy. To evaluate patient acceptability and pathology logistics of determining the risk profile, a pilot phase was included in the study. METHODS: PORTEC-4a is ongoing and the first 50 patients enrolled were included in the pilot phase...
August 2, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30078257/-primary-study-on-the-relationship-between-high-risk-hpv-infection-and-vaginal-cervical-microbiota
#2
Z Zhang, D Zhang, B B Xiao, R Zhang, H H Bai, H Y Dong, H Bi, Z H Liu
Objective: To understand characteristics of vaginal cervical microbiota in high-risk HPV (hrHPV) infected women and to uncover the relationship between hrHPV infection and vaginal cervical microbiota. Methods: All participants were randomly selected from Peking University First Hospital from September to October of 2017, including 5 subjects of control group, 5 cases of HPV16/18 group, 5 cases of other hrHPV infected group and 3 cases of cervical squamous carcinoma group. All subjects were required to fill in a questionnaire, and cervical and vaginal discharges were separately collected for microscopic examination and new generation sequencing targeting the variable region (V3-V4) of bacterial 16S rRNA gene...
July 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/30065494/use-of-ultrasonography-in-clarifying-the-etiology-of-anal-pain
#3
Ashraf Talaat Youssef
Introduction: Anal pain is defined as pain originating from the anal canal or the perianal area that can be attributed to a variety of medical problems. The current study's aim was to evaluate the role of combined endoanal, transperineal, and in married women, transvaginal ultrasound in clarifying the etiology of anal pain among our patient study group. Methodology: A total of 180 patients presented to our radiology department complaining of anal pain and were examined using transperineal, endoanal, and in women, transvaginal ultrasound aided with three-dimensional capability...
October 2017: Journal of Medical Ultrasound
https://www.readbyqxmd.com/read/30064005/vaginal-closure-with-endogia-to-prevent-tumor-spillage-in-laparoscopic-radical-hysterectomy-for-cervical-cancer
#4
Gokhan Boyraz, Alper Karalok, Derman Basaran, Taner Turan
STUDY OBJECTIVE: To demonstrate a method of vaginal closure with EndoGIA surgical stapler to prevent tumor spillage in laparoscopic radical hysterectomy. DESIGN: Step-by-step explanation of the procedure using video. SETTING: Women's Health Teaching and Research Hospital. PATIENT: A 40-year-old woman with clinical stage IBI cervical squamous cell carcinoma. INTERVENTION: Laparoscopic type C radical hysterectomy with pelvic lymph node dissection and ovarian transposition...
July 28, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/30060799/metastatic-squamous-cell-carcinoma-versus-primary-high-grade-serous-carcinoma-of-the-ovary
#5
Feng Zhou, Wen Wang, Lili Huang
We report an extremely rare case of abnormal vaginal bleeding in a 66-year postmenopausal woman. A sterile speculum examination revealed no obvious tumour mass in the cervix. Serum levels of cancer antigen 125 and carcinoembryonic antigen were elevated at 480.3 IU/L and 19.3 ng/ml, respectively. Ultrasound showed a 4 × 3 × 2 cm hypoechoic solid mass on the left uterine adnexa, a 4-5 cm mass in the right adnexa, a 4 cm mass in the vesicouterine excavation and a 4-5 cm mass in the omentum. Finally, debulking surgery with tumour resection was performed...
August 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/30036223/use-of-aggressive-surveillance-for-locoregional-endometrial-cancer-after-local-therapy
#6
Pratyusha Yalamanchi, Jacob E Shabason, Xiaochen Zhang, Emily M Ko, Lilie L Lin
PURPOSE/OBJECTIVES: Current guidelines do not recommend routine surveillance imaging as part of follow-up care for patients treated for locoregional endometrial carcinoma. This study seeks to determine the potential benefit of routine surveillance imaging by evaluating outcomes of patients whose recurrences were detected on routine surveillance compared to those whose recurrences were identified after presenting with symptoms. MATERIALS/METHODS: We conducted a retrospective review of patients who developed recurrence after surgical treatment, with or without adjuvant therapy, for locoregional endometrial carcinoma...
July 20, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/30036218/undifferentiated-endometrial-carcinomas-clinicopathologic-characteristics-and-treatment-outcomes
#7
Rohit Gunan Ganju, Ossama Tawfik, Laura Brown, Allen M Chen, Andrea Jewell, Mindi TenNapel, Andrew Hoover
OBJECTIVE: Undifferentiated endometrial carcinoma (UEC) represents a recently recognized and rare diagnosis that is commonly misclassified on histopathologic evaluation. These cancers account for less than 10% of carefully reviewed series of endometrial cancers from academic medical centers. We reviewed a single-institutional experience with the management of UEC focusing on clinicopathologic characteristics and treatment outcomes. METHODS: The medical records of all patients treated for histologically proven endometrial carcinoma between 2007 through 2016 were reviewed...
July 20, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29996316/-clinicopathologic-analysis-of-primary-carcinoid-of-the-ovary
#8
H J Ge, R Bi, Y F Cheng, B Chang, L Yu, S X Tang, X X Shen, W T Yang, X Y Tu
Objective: To describe the clinicopathologic features, diagnosis and differential diagnosis of ovarian carcinoid tumors. Methods: A retrospective chart review was performed of all patients diagnosed with primary ovarian carcinoid tumors at Fudan University Shanghai Cancer Centre from 2007 to 2017. Results: The histologic analysis of these carcinoid tumors revealed 3 were insular, 1 was trabecular, 1 was mucinous, and 10 were strumal. Histologic features of insular and trabecular carcinoid were similar to other parts of the neuroendocrine tumor...
July 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29978593/patient-initiated-follow-up-affects-fear-of-recurrence-and-health-care-use-a-randomized-trial-in-early-stage-endometrial-cancer
#9
M M Jeppesen, P T Jensen, D G Hansen, R D Christensen, O Mogensen
OBJECTIVE: To test the hypothesis that patient-initiated follow-up reduces fear of cancer recurrence (FCR) and health care use when compared to traditional hospital-based follow-up. DESIGN: Pragmatic, multi-centre randomized trial. SETTING: Four Danish departments of gynaecology between May 2013 and May 2016. POPULATION: 156 women diagnosed with International Federation of Gynaecology and Obstetrics (FIGO) stage I low-intermediate risk endometrial carcinoma METHODS: Women allocated to the control group attended hospital-based follow-up consisting of regular out-patient visits for three years after primary treatment...
July 6, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29977425/unusual-features-of-clear-cell-adenocarcinoma-of-the-female-urethra-a-case-report-and-literature-review
#10
Jianfeng Zeng, Shanyun Wang, Liang Zhong, Zhifeng Huang, Ye Zeng, Song Wu, Dongxiang Zheng, Weiwei Zou, Haibiao Lai
Background: There has been scarce information about clear cell adenocarcinoma of the urethra (CCAU), an extremely rare type of cancer. A few case reports show that CCAU tends to have similar clinical manifestation to the other urethral carcinomas, urethrocystoscopy can easily identify tumoral lesions in the urethra, and bloody drainage from the urethral meatus is often seen during physical exams. Methods: A 52-year-old woman presented with dysuria for 6 months. Urethrocystoscopy did not reveal abnormality, and there was no bloody vaginal drainage or bloody drainage from the urethral meatus during physical exams...
August 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29967708/vaginal-bleeding-as-initial-presentation-of-an-aggressive-renal-cell-carcinoma-a-case-report-and-review-of-the-literature
#11
Antonio R Jimenez, Maria Del Mar Rivera Rolon, Eduardo Eyzaguirre, Cecilia Clement
Introduction: Renal cell carcinoma is the third most common urogenital cancer. In some patients, it can metastasize to distant organs. Metastasis to the vagina is extremely rare. Case Presentation: A 54-year-old female with unremarkable history presented to the clinic with a chief complaint of vaginal bleeding. Further examination identified a pedunculated mass on the vaginal wall. Histologic examination revealed a metastatic clear cell renal cell carcinoma. Radiological studies then revealed a left renal mass and bilateral adrenal masses...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29957613/an-overview-of-anal-intraepithelial-neoplasia
#12
Corina L Buzard, Denise Rizzolo
Anal intraepithelial neoplasia (AIN) and anal squamous cell carcinoma (ASCC) are on the rise in the United States, especially among men who have sex with men, HIV-positive or other immunocompromised patients, and women with a history of cervical, vaginal, or vulvar cancer. Strong evidence supports the human papillomavirus as the causative factor in anal dysplasia; reducing the risk of HPV infection can reduce rates of ASCC. High-risk patients should be screened for AIN, but no universal screening guidelines exist, and more studies are needed to develop a national protocol for screening and management of patients with AIN...
July 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29950369/stage-1-small-cell-cancer-of-the-vagina
#13
Tarek Haykal, Trailokya Pandit, Ghassan Bachuwa, Rizwan Danish
This is the case of a 56-year-old white woman with a medical history significant for chronic obstructive pulmonary disease, migraine, hypertension, tobacco abuse and hypercholesterolaemia. Her surgical history is significant for total hysterectomy and bilateral salpingo-oophorectomy for diffuse endometriosis. The patient presented with a vaginal lesion. The biopsy was positive for primary vaginal small cell carcinoma and human papilloma virus (HPV). Initial staging positron emission tomography (PET) scan confirmed stage 1 disease...
June 27, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29943205/anal-gland-adenocarcinoma-in-situ-with-pagetoid-spread-a-case-report
#14
Kohei Ishioka, Fumikazu Koyama, Hiroyuki Kuge, Takashi Inoue, Shinsaku Obara, Takayuki Nakamoto, Yoshiyuki Sasaki, Yasuyuki Nakamura, Maiko Takeda, Chiho Ohbayashi, Masamitsu Kuwahara, Masayuki Sho
BACKGROUND: Anal gland carcinoma with perianal Paget's disease is rare, and anal gland carcinoma in situ is extremely rare. No cases of anal gland carcinoma in situ with pagetoid spread have been previously reported. CASE PRESENTATION: Physical examination in a 75-year-old woman revealed an erythematous, inflamed, perianal skin lesion. Neither colposcopy, cystoscopy, colonoscopy, computed tomography, nor magnetic resonance imaging showed evidence of malignant genitourinary or gastrointestinal lesions...
June 25, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29937242/cutaneous-metastases-from-neuroendocrine-carcinoma-of-the-cervix-an-unusual-metastatic-lesion-from-an-uncommon-malignancy
#15
Bharti Devnani, Ritesh Kumar, Sushmita Pathy, Ravi Hari Phulware, Sandeep Mathur, Lalit Kumar
Neuroendocrine carcinoma (NEC) is an uncommon and aggressive type of small cell cervical cancer. NECs mostly arise from gastro-entero-pancreatic tract and the lung, but rarely from other organs like cervix. NEC of the cervix is a rare malignancy and constitutes 0.9%-1.5% of cervical tumors. NECs of cervix are common in perimenopausal females and present with abnormal vaginal bleeding and mimic squamous cell cancers, usually with no distinguishing features. On Immunohistochemistry, presence of chromogranin, synaptophysin, and CD-56 is necessary to make a diagnosis of small cell carcinoma...
May 23, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29933751/alpha-fetoprotein-producing-ovarian-clear-cell-adenocarcinoma-with-fetal-gut-differentiation-a-rare-case-report-and-literature-review
#16
Wei-Ting Chao, Chia-Hao Liu, Chiung-Ru Lai, Yi-Jen Chen, Chi-Mu Chuang, Peng-Hui Wang
BACKGROUND: Alpha-fetoprotein (AFP) is a useful tumor marker for ovarian germ cell tumors, particularly yolk sac tumor (YST). It is valuable for both diagnosis and further follow-up. Epithelial ovarian carcinoma (EOC) rarely secretes AFP, especially for clear cell type and in the postmenopausal women. Based on the limited knowledge about AFP-producing clear cell type EOC, a case and literature review on this topic is extensively reviewed. CASE PRESENTATION: We report a 55-year-old postmenopausal woman experienced vaginal spotting for one month, and serum level of AFP was 60,721 ng/ml initially...
June 22, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29915804/using-advanced-wound-care-and-hyperbaric-oxygen-to-manage-wound-complications-following-treatment-of-vulvovaginal-carcinoma
#17
C Griffiths, R S Howell, H Boinpally, E Jimenez, E Chalas, F Musa, S Gorenstein
Postoperative management of patients with vulvar cancer is associated with a high incidence of poor wound healing and radiation -induced late tissue necrosis. This case series demonstrates the impact on wound healing with the use of hyperbaric oxygen therapy and advanced wound care following radical vulvectomy and/or radiation therapy. A retrospective case series was performed of all patients from 2016 to 2017 with lower genital cancer who underwent radical surgery with or without chemoradiation treatment, experienced wound dehiscence or late tissue radionecrosis, and were treated with advanced wound care, including hyperbaric oxygen therapy (HBO)...
May 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29901630/three-primary-synchronous-malignancies-of-the-uterus-cervix-and-fallopian-tube-a-case-report
#18
Liang Song, Qingli Li, Kaixuan Yang, Rutie Yin, Danqing Wang
RATIONALE: Multiple primary malignancies can occur in the same organ or in multiple organs or systems. Likewise, they can occur simultaneously or successively. Based on the timing of the diagnosis, they are classified as multiple synchronous (i.e., concurrent) or metachronous (i.e., successive) primary malignancies. The vast majority of patients have multiple metachronous malignant tumors; multiple synchronous tumors are rare. PATIENT CONCERNS: A 63-year-old woman presented with the chief complaint of vaginal fluid discharge for 3 months and abdominal pain for 1 month...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901522/expression-of-markers-of-m%C3%A3-llerian-clear-cell-carcinoma-in-primary-cervical-and-vaginal-gastric-type-adenocarcinomas
#19
Karen L Talia, Richard Wing-Cheuk Wong, W Glenn McCluggage
The incidence of cervical adenocarcinoma, both absolute and relative to squamous cell carcinoma, is increasing. Most cervical adenocarcinomas are human papillomavirus associated, although non-human papillomavirus-associated neoplasms exist; the latter include gastric-type adenocarcinoma (GAS) and clear cell carcinoma (CCC). Histologically, these 2 tumors may superficially resemble one other and although morphologic evaluation usually permits a correct diagnosis, immunohistochemistry may be required to resolve diagnostic uncertainty, especially in a small biopsy specimen...
June 12, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29887722/a-long-standing-primary-vaginal-paraganglioma-coexisting-with-esophageal-carcinoma
#20
Saniya Sharma, Abhijit Chougule, Rashi Garg, Seema Chopra, Pooja Sikka
No abstract text is available yet for this article.
June 2018: Indian Journal of Surgical Oncology
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