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https://www.readbyqxmd.com/read/30517328/adipose-tissue-derived-mesenchymal-stem-cell-transplantation-in-the-treatment-of-ischemia-reperfusion-induced-acute-kidney-injury-in-rats-application-route-and-therapeutic-window1
#1
Betânia Souza Monteiro, Bianka Souza Dos Santos, Bruna Lopes de Almeida, Emy Hiura, Wagner Alexey Back Fiorio, Gisele Pereira Valdetaro, Dariele Vieira Gonçalves, Caroline Saraiva Silva, Tatiana Champion, Daniela Campagnol
PURPOSE: To evaluate renal repair in rats who had renal infarction induced by the obstruction of blood flow in the renal artery and were treated with transplantation of adipose tissue derived mesenchymal stem cell. METHODS: 16-week-old Wistar rats (n=72) were used, submitted to celiotomy and had of the renal artery and vein clipped for 24 hours. The animals were randomly assigned to 10 experimental homogeneous groups, corresponding to the treatments with phosphate-buffered saline (PBS) or adipose tissue derived mesenchymal stem cell (ADSC), duration of application (24 or 48 hours), and site of transplantation (lateral vein of the tail or intrarenal)...
November 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30516426/dynamic-contrast-enhanced-dce-mri-promotes-early-detection-of-toxin-induced-acute-kidney-injury-aki
#2
Jamie R Privratksy, Nian Wang, Yi Qi, Jiafa Ren, Benjamin T Morris, John C Hunting, G Allan Johnson, Steven D Crowley
Acute kidney injury (AKI) is a common cause of morbidity and mortality in hospitalized patients. Nevertheless, there is limited ability to diagnose AKI in its earliest stages through the collection of structural and functional information. Imaging modalities such as magnetic resonance imaging (MRI) are increasingly being utilized to provide structural and functional data that characterize the injured kidney. Dynamic contrast-enhanced (DCE) MRI is an imaging modality that measures changes in kidney structure and contrast transit times; however, its ability to detect these parameters following AKI has not been determined...
December 5, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/30515564/botryoid-wilms-tumor-a-non-existent-entity-causing-diagnostic-and-staging-difficulties
#3
Gordan M Vujanić, Marco Schiavo Lena, Neil J Sebire
Wilms tumors growing in a botryoid fashion into the renal pelvis have been reported since the 1960s as a rare tumor type usually associated with stromal histology and a good prognosis. However, the true frequency, association with Wilms tumor subtypes, and stage have never been comprehensively studied. We analyzed all Wilms tumors enrolled into the International Society of Paediatric Oncology (SIOP) United Kingdom 2001 Trial (2001-2011), which showed botryoid growth. In addition, we reviewed published series reporting papers on botryoid Wilms tumors...
December 4, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/30514440/5-aminolaevulinic-acid-ala-enhances-heme-oxygenase-ho-1-expression-and-attenuates-tubulointerstitial-fibrosis-and-renal-apoptosis-in-chronic-cyclosporine-nephropathy
#4
Chi Liu, Ping Zhu, Masayuki Fujino, Yoshitaka Isaka, Hidenori Ito, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Jian Zhuang, Xiao-Kang Li
BACKGROUND: Cyclosporine-A (CsA) is an immunosuppressant indicated for various immunological diseases; however, it can induce chronic kidney injury. Oxidative stress and apoptosis play a crucial role in CsA-induced nephrotoxicity. The present study evaluated the protective effect of combining 5-aminolaevulinic acid with iron (5-ALA/SFC), a precursor of heme synthesis, to enhance HO-1 activity against CsA-induced chronic nephrotoxicity. METHODS: Mice were divided into three groups: the control group (using olive oil as a vehicle), CsA-only group, and CsA+5-ALA/SFC group...
December 1, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30511629/protective-effect-of-date-extract-on-rat-nephrotoxicity-induced-by-gentamicin-clinical-histological-and-antioxidant-evidences
#5
Ozgur Yasar Celik, Kivanc Irak
In this study, it was aimed to investigate the effect of the date extract (Phoenix dactylifera) on certain biochemical parameters and total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index in nephrotoxicity induced by gentamicin. The rats used in the study were randomly selected and divided into 4 groups, each consisting of 8 rats: control group, date extract (DE) group, gentamicin (GEN) group, gentamicin+date extract (GEN+DE) group. Blood samples and kidney tissues were taken 24 hours after eight days of trial...
November 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/30511250/long-non-coding-rna-hottip-affects-renal-cell-carcinoma-progression-by-regulating-autophagy-via-the-pi3k-akt-atg13-signaling-pathway
#6
Yang Su, Jingxiao Lu, Xianguo Chen, Chaozhao Liang, Pengcheng Luo, Cong Qin, Jie Zhang
OBJECTIVE: Renal cell carcinoma (RCC) is the most common malignancy of the urinary system, and it is a serious threat to human health. HOXA transcript at the distal tip (HOTTIP), located at the 5' end of the HOXA locus, is a long non-coding RNA that has been newly discovered in recent years. It has been reported to promote the development of several types of tumors. Moreover, accumulating evidence has indicated that autophagy plays an important role in tumor cell survival or death. However, whether HOTTIP affects RCC development by regulating autophagy remains unknown...
December 3, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/30509098/radiotherapy-of-prostate-cancer-in-renal-transplant-recipients-single-center-experience
#7
M Gojdic, Z Zilinska, I Krajcovicova, P Lukacko, J Grezdo, B Obsitnik, J Breza, B Trebaticky
This study analyzed the long-term outcomes of localized prostate cancer in renal transplant recipients after radiotherapy treatment - mainly brachytherapy. We retrospectively analyzed clinical data of renal transplant recipients between 2003 and 2016 at a single tertiary center, and identified four patients with high serum PSA level during regular follow-up, 1-108 months after primary renal transplantation. The mean age of patients with detected high serum PSA level with 9.25µg/l median was 59.05 years. All four patients had functioning grafts...
September 4, 2018: Neoplasma
https://www.readbyqxmd.com/read/30507616/papillary-renal-cell-carcinoma-prcc-an-update
#8
Mohammed Akhtar, Issam A Al-Bozom, Turki Al Hussain
Papillary renal cell carcinoma (PRCC) is the second most common type of renal carcinoma following clear cell renal cell carcinoma. Papillary renal cell carcinoma is usually divided histologically into 2 types namely, type 1 and type 2. This classification, however, is unsatisfactory as many of papillary carcinoma are unclassifiable by the existing criteria. In recent years there has been a remarkable progress in our understanding of the molecular basis of PRCC. These studies have revealed that type 2 PRCCs represent a heterogenous group which may be subdivided into additional subtypes based on the genetic and molecular make up of these tumors and reflecting different clinical course and prognosis...
November 30, 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/30502717/papillary-pattern-in-clear-cell-renal-cell-carcinoma-clinicopathologic-morphologic-immunohistochemical-and-molecular-genetic-analysis-of-23-cases
#9
Reza Alaghehbandan, Monika Ulamec, Petr Martinek, Kristyna Pivovarcikova, Kvetoslava Michalova, Faruk Skenderi, Milan Hora, Michal Michal, Ondrej Hes
Clear cell renal cell carcinoma (ccRCC), the most common histologic subtype of RCCs, demonstrates a wide spectrum of morphologic features (i.e., low-grade spindle cell, syncytial giant cells, and mucin-producing cells). However, papillary growth pattern in ccRCCs is rather a rare finding, which can present challenges in differential diagnostic work up. The aim of this study was to investigate ccRCCs with predominant papillary features from morphologic, immunohistochemical and molecular genetic perspectives...
November 22, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/30502252/sirt3-inactivation-promotes-acute-kidney-injury-through-elevated-acetylation-of-sod2-and-p53
#10
Jie Ouyang, Zhenhua Zeng, Haihong Fang, Fei Li, Xinji Zhang, Wanlong Tan
BACKGROUND: The deactivation of SIRT3, a novel deacetylase located in mitochondria, can aggravate multiple organ dysfunction. However, the role of SIRT3 and its downstream targets in ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) remain unknown. MATERIALS AND METHODS: I/R was reproduced in a rat model using a clamp placed on the left and right renal pedicles for 40 min. The rats were intraperitoneally injected with either the vehicle or a selective SIRT3 inhibitor (3-TYP) and scarified at different time points (4, 8, and 24 h after I/R)...
January 2019: Journal of Surgical Research
https://www.readbyqxmd.com/read/30501900/effects-of-ischemic-preconditioning-and-postconditioning-in-a-renal-ischemia-reperfusion-injury-model-a-comparative-experimental-study-in-rats
#11
V M Arantes, R T Bueno, R P Módolo, M A C Domingues, L R de Carvalho, P do Nascimento Junior, N S P Módolo
BACKGROUND: Ischemia-reperfusion injury is an unavoidable aspect of transplantation, as well as an important cause of acute kidney injury in clinical practice. Pre- and post-ischemic conditioning are strategies that may provide organs with resistance to major ischemic events. This study evaluates the effects of ischemic preconditioning and ischemic postconditioning, either separately or in combination, after an acute ischemia-reperfusion kidney injury. METHODS: Forty Wistar rats received isoflurane anesthesia and were randomized into 5 groups: 1...
November 27, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30501397/remote-ischemic-per-conditioning-protects-against-renal-ischemia-reperfusion-injury-via-suppressing-gene-expression-of-tlr4-and-tnf-%C3%AE-in-rat-model
#12
Firouzeh Gholampour, Jamshid Roozbeh, Sahar Janfeshan, Zeinab Karimi
BACKGROUND: The pathogenesis of renal ischemic reperfusion injury (IRI) involves both inflammatory processes and oxidative stress in the kidney. This study determined whether remote ischemic per-conditioning (RIPerC) is mediated by toll-like receptor 4 (TLR4) signaling pathway in rats. MATERIALS AND METHODS: Renal I/R injury was induced by occluding renal arteries for 45 min followed by 24 h reperfusion. RIPerC included four cycles of 2 minutes ischemia of left femoral artery followed by 3 minutes reperfusion performed at the start of renal ischemia...
December 2, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/30501137/the-preventive-effect-of-aqueous-extract-of-rosemary-rosmarinus-officinalis-leaves-against-the-nephrotoxicity-of-carbon-tetrachloride-in-mice
#13
Houda Hamed, Salha Boulila, Ferdaws Ghrab, Rim Kallel, Tahia Boudawara, Abdelfattah El Feki
The present study aimed to evaluate the performance effect of aqueous extract of Rosmarinus officinalis (AERO) against the kidney toxicity induced by CCl4 in mice. The results showed that the renal damage induced by CCl4 was associated with a rise in oxidative stress monitored by a significant increase of TBARS and PCO levels (+89% and +136% respectively, p < .001) and a significant decrease of GSH level (-68%, p < .001) and antioxidants enzymes such as SOD, CAT, and GPX activities (-41.7%, -47...
November 30, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30501008/the-clinical-and-pathological-significance-of-borderline-t-cell-mediated-rejection
#14
Brian J Nankivell, Nidhi Agrawal, Ankit Sharma, Anne Taverniti, Chow H P'Ng, Meena Shingde, Germaine Wong, Jeremy R Chapman
The pathological diagnosis of borderline rejection (BL-R) denotes possible T cell mediated rejection (TCMR), but its clinical significance is uncertain. This single-centre, cross-sectional cohort study compared the functional and histological outcomes of consecutive BL-R diagnoses (n=146) against normal controls (n=826) and acute TCMR (n=55) from 551 renal transplant recipients. BL-R was associated with: contemporaneous renal dysfunction, acute tubular necrosis and chronic tubular atrophy (P<0.001); progressive tubular injury with fibrosis by longitudinal sequential histology (45...
November 30, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/30501003/tauroursodeoxycholic-acid-tudca-abolishes-chronic-high-salt-induced-renal-injury-and-inflammation
#15
C De Miguel, R Sedaka, M Kasztan, J M Lever, M Sonnenberger, A Abad, C Jin, P K Carmines, D M Pollock, J S Pollock
AIM: Chronic high salt intake exaggerates renal injury and inflammation, especially with the loss of functional ETB receptors. Tauroursodeoxycholic acid (TUDCA) is a chemical chaperone and bile salt that is approved for the treatment of hepatic diseases. Our aim was to determine whether TUDCA is reno-protective in a model of ETB receptor deficiency with chronic high salt-induced renal injury and inflammation. METHODS: ETB -deficient and transgenic control rats were placed on normal (0...
November 30, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/30500779/the-ethanol-leaf-extract-of-andrographis-paniculata-blunts-acute-renal-failure-in-cisplatin-induced-injury-in-rats-through-inhibition-of-kim-1-and-upregulation-of-nrf2-pathway
#16
Bisi O Adeoye, Ademola A Oyagbemi, Ebunoluwa R Asenuga, Temidayo O Omobowale, Adeolu A Adedapo
Background Cisplatin (CP) is a novel drug of choice in the treatment of cancer but its major limitation is nephrotoxicity, which is dose limiting. Andrographis paniculata (AP) is a common Indian dietary component. It is well known for its medicinal properties. This present study investigated the nephroprotective effect of ethanol leaf extract of Andrographis paniculata (EEAP) on CP-induced nephrotoxicity. Methods CP was used to induce nephrotoxicity in male Wistar rats to study the effect of EEAP on renal damages using hematological parameters, biochemical parameters, histology, and immunohistochemistry studies...
November 30, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30500642/angiosarcoma-of-a-thrombosed-arteriovenous-fistula-in-a-renal-transplant-recipient
#17
John D Kakisis, Constantine Antonopoulos, Konstantinos Moulakakis, Athanasios Taliadoros, Dimitra Rontogianni, Elias Brountzos, Christos Liapis, George Geroulakos
Angiosarcomas developing in non-functioning arteriovenous fistulae in renal transplant recipients are quite rare clinical entities with very poor prognosis. Herein we present a 60-year-old male who developed an angiosarcoma in a thrombosed radiocephalic fistula six years after renal transplantation. The patient presented with pain and swelling at the site of a previously asymptomatic fistula. The fistula was excised and diagnosis was made by histology. Despite radical surgery with an above-elbow amputation, the patient died of metastatic disease six months later...
November 27, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30497128/hypoxic-preconditioned-mesenchymal-stromal-cell-therapy-in-a-rat-model-of-renal-ischemia-reperfusion-injury-development-of-optimal-protocol-to-potentiate-therapeutic-efficacy
#18
Myoung Jin Jang, Dalsan You, Jin Young Park, Kyung Kim, Joomin Aum, Chunwoo Lee, Geehyun Song, Ha Chul Shin, Nayoung Suh, Yong Man Kim, Choung-Soo Kim
Although previous and ongoing clinical studies have used stromal cells during renal ischemia-reperfusion injury (IRI), there is little consensus regarding the optimal protocol. We aimed to optimize the protocol for hypoxic preconditioned human bone marrow-derived mesenchymal stromal cell (HP-hBMSC) therapy in a rat model of renal IRI. We determined the optimal injection route (renal arterial, renal parenchymal, and tail venous injection), dose (low-dose: 1×106 , moderate-dose: 2×106 , and high-dose: 4×106 ), and injection period (pre-, concurrent-, and post-IRI)...
November 30, 2018: International Journal of Stem Cells
https://www.readbyqxmd.com/read/30488204/ectopic-organogenesis-after-allotransplantation-of-freshly-removed-or-cryopreserved-neonatal-testicle-under-the-renal-capsule-in-rats
#19
V I Kirpatovskii, G D Efremov, E V Frolova
In experiments on white outbred male rats, a freshly removed (20 experiments) or cryopreserved (10 experiments) testicle from newborn rats (1-2 days after birth) was transplanted under the renal capsule after bilateral orchiectomy. In all experiments with transplantation of freshly removed testicle, it was engrafted. In 3 months, histological examination revealed the formation of mature seminiferous tubules, but spermatogenesis was blocked at the stage of spermatogonia; groups of proliferating Leydig cells in the loose connective tissue between the tubules were also seen...
December 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/30484345/patients-with-hypokalemia-develop-wnk-bodies-in-the-distal-convoluted-tubule-of-the-kidney
#20
Martin N Thomson, Wolfgang Schneider, Kerim Mutig, David H Ellison, Ralph Kettritz, Sebastian Bachmann
Hypokalemia contributes to the progression of chronic kidney disease, while a definitive pathophysiogical theory to explain this remains to be established. K+ deficiency results in profound alterations of renal epithelial transport. These include an increase of salt reabsorption via the Na+ ,Cl- -cotransporter (NCC) of the distal convoluted tubule (DCT), which minimizes electroneutral K+ loss in downstream nephron segments. In experimental conditions of dietary K+ depletion, punctate structures in the DCT containing crucial NCC-regulating kinases have been discovered in the murine DCT and termed "WNK bodies", referring to their component, with no lysine (WNK) kinases...
November 28, 2018: American Journal of Physiology. Renal Physiology
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