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https://www.readbyqxmd.com/read/30098279/anti-carcinogenic-effect-of-hesperidin-against-renal-cell-carcinoma-by-targeting-cox-2-pge2-pathway-in-wistar-rats
#1
Aisha Siddiqi, Bano Saidullah, Sarwat Sultana
The present study was designed to evaluate the protective effects of hesperidin, a flavonoid on DEN initiated and Fe-NTA promoted renal carcinogenesis in Wistar rats. Renal cancer was initiated by a single i.p. injection of DEN (200 mg/kg b.wt.) and promoted with Fe-NTA (9 mg Fe/kg b.wt. i.p.) twice a week for 16 weeks. Rats were simultaneously administered with hesperidin (100 and 200 mg/kg b.wt.) for 16 consecutive weeks. The chemopreventive effect of hesperidin was assessed in terms of antioxidant activities, renal function, PGE2 level, and the expressions of COX-2 and VEGF...
August 11, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/30096705/a-pooled-analysis-of-published-basket-trials-in-cancer-medicine
#2
Antonious Hazim, Vinay Prasad
BACKGROUND: There is widespread interest in cancer basket trials. However, to date, there has been no formal analysis of all published basket trials. METHODS: We performed a systematic review to identify all published basket trials in cancer medicine. We included studies that (1) did not place restriction on tumour type and (2) used a biomarker for the basis of enrolment (3) administered at least one anti-cancer agent in prospective fashion and (4) reported responses by each tumour type included...
August 7, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/30096533/igg4-related-disease-mimicking-pancreatic-cancer-case-report-and-review-of-the-literature
#3
Ibnouf Sulieman, Ahmed Mahfouz, Einas AlKuwari, Lajos Szabados, Walid Elmoghazy, Ahmed Elaffandi, Hatem Khalaf
INTRODUCTION: Most patients with pancreatic masses pose a diagnostic challenge when a benign lesion is suspected, and often, resection is needed before a benign diagnosis is confirmed. PRESENTATION OF CASE: A 57 years old male patient presented with a pancreatic head mass, obstructive jaundice and submandibular lymph node enlargement. He also had a history of recurrent eye pain and redness, skin lesions, and benign prostatic hypertrophy. MRI showed a pancreatic head mass with double duct sign, aortic thickening, bilateral renal lesions, diffuse lymph node enlargement, and prostatic enlargement...
July 31, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30096408/sympathoadrenergic-suppression-improves-heart-function-by-upregulating-the-ratio-of-srage-rage-in-hypertension-with-metabolic-syndrome
#4
Simina-Ramona Selejan, Dominik Linz, Anna-Maria Tatu, Mathias Hohl, Thimoteus Speer, Sebastian Ewen, Felix Mahfoud, Ingrid Kindermann, Olesja Zamyatkin, Andrey Kazakov, Ulrich Laufs, Michael Böhm
Receptors-for-Advanced-Glycation-End-products (RAGE) activate pro-inflammatory programs mediated by carboxymethyllysine (CML) and high-mobility-group-box1 protein (HMGB1). The soluble isoform sRAGE neutralizes RAGE-ligands preventing cardiovascular complications in conditions associated with increased sympathetic activation like hypertension and diabetes. The effects of sympathetic modulation on RAGE/sRAGE-balance and end-organ damage in metabolic syndrome on top of hypertension remains unknown. We hypothesized that increased sympathoadrenergic activity might lead to an unfavourable RAGE/sRAGE regulation...
August 7, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/30095709/the-clinical-features-of-recurrent-endometrial-cancer-in-japan-chemotherapy-instead-of-radiotherapy-as-postoperative-adjuvant-treatment
#5
Haruko Iwase, Seigi Furukawa, Takeshi Hirasawa, Satoshi Asai, Tatsuru Ohara, Shinji Hosonuma, Shinichi Endo, Yuki Tazo, Hidetaka Sato, Toshio Takada, Masahide Arai, Masae Ikeda, Masako Shida, Norihito Yoshioka, Akiko Tozawa-Ono, Nao Suzuki, Mikio Mikami, Takashi Onda
OBJECTIVE: Chemotherapy is a standard adjuvant treatment after primary surgery for endometrial cancer in Japan. We aimed to characterize the clinical features of recurrent endometrial cancer (REC) patients in Japan. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 112 REC patients who were primarily treated at 1 of 3 university hospitals in Japan from 2005 to 2012. We analyzed overall survival since the first recurrence (R-OS) in accordance with several factors...
August 7, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/30094012/membranoproliferative-glomerulonephritis-and-c3-glomerulopathy-in-children-change-in-treatment-modality-a-report-of-a-case-series
#6
Giuseppina Spartà, Ariana Gaspert, Thomas J Neuhaus, Marcus Weitz, Nilufar Mohebbi, Urs Odermatt, Peter F Zipfel, Carsten Bergmann, Guido F Laube
Background: Membranoproliferative glomerulonephritis (MPGN) with immune complexes and C3 glomerulopathy (C3G) in children are rare and have a variable outcome, with some patients progressing to end-stage renal disease (ESRD). Mutations in genes encoding regulatory proteins of the alternative complement pathway and of complement C3 (C3) have been identified as concausative factors. Methods: Three children with MPGN type I, four with C3G, i.e. three with C3 glomerulonephritis (C3GN) and one with dense deposit disease (DDD), were followed...
August 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/30094010/seasonal-variations-in-the-onset-of-positive-and-negative-renal-anca-associated-vasculitis-in-spain
#7
Juliana Draibe, Xavier Rodó, Xavier Fulladosa, Laura Martínez-Valenzuela, Montserrat Diaz-Encarnación, Lara Santos, Helena Marco, Luis Quintana, Eva Rodriguez, Xoana Barros, Rosa Garcia, Anna Balius, Josep M Cruzado, Joan Torras
Background: The closure of long-standing gaps in our knowledge of aetiological factors behind anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a major challenge. Descriptive and analytical epidemiological studies can improve our understanding of environmental influences. Reported seasonal variations in AAV, mainly related to Wegener's disease, have shown an increasing number of cases in the winter months, which could be related to an extrinsic factor underlying infection...
August 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/30093458/phosphate-binder-ferric-citrate-attenuates-anemia-renal-dysfunction-oxidative-stress-inflammation-and-fibrosis-in-5-6-nephrectomized-ckd-rats
#8
Wanghui Jing, Ane Nunes, Ted Farzaneh, Mahyar Khazaeli, Wei Ling Lau, Nosratola D Vaziri
Chronic kidney disease (CKD) causes anemia and impairs intestinal iron absorption. However, use of the phosphate binder, ferric citrate (FC), increases body iron stores and hemoglobin levels in CKD patients. By intensifying oxidative stress and inflammation iron overload can accelerate CKD progression. Present study explored the route of absorption and tissue distribution of iron with FC administration and its effect on renal function, histology and inflammatory, oxidative and fibrosis pathways in CKD rats...
August 9, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/30092734/the-current-role-for-clinical-and-renal-histological-findings-as-predictor-for-outcome-in-australian-patients-with-lupus-nephritis
#9
J Nossent, W Raymond, A Kang, D Wong, M Ognjenovic, A Chakera
Objectives To investigate the current demographic, clinical and histological characteristics of patients with lupus nephritis (LN) in Western Australia (WA) with regards to their predictive value for patient and renal outcome. Methods Retrospective study of adult systemic lupus erythematosus (SLE) patients with a first renal biopsy demonstrating LN between 1997 and 2017 at a metropolitan tertiary hospital in WA. Clinical data were collected at baseline and last follow-up with renal biopsy findings classified by International Society of Nephrology (ISN) criteria...
August 9, 2018: Lupus
https://www.readbyqxmd.com/read/30091262/histopathology-and-external-examination-of-heavily-parasitized-lost-river-sucker-deltistes-luxatus-cope-1879-and-shortnose-sucker-chasmistes-brevirostris-cope-1879-from-upper-klamath-lake-oregon
#10
Andrew J Janik, Douglas F Markle, Jerry R Heidel, Michael L Kent
Shortnose Sucker (Chasimistes brevirostris) and Lost River Sucker (Deltistes luxatus) are endemic to the Upper Klamath Basin of Southern Oregon and Northern California, and their populations are in decline. We used histopathology and external examination of 140 and external examination only of 310 underyearling suckers collected in 2013, 2015 and 2016 to document pathological changes, particularly those relating to parasites. The most severe infection was caused by a Contracaecum sp., infecting the atrium of 8%-33% of Shortnose Suckers...
August 9, 2018: Journal of Fish Diseases
https://www.readbyqxmd.com/read/30090707/case-of-human-immunodeficiency-virus-infection-presenting-as-a-tip-variant-of-focal-segmental-glomerulosclerosis-a-case-report-and-review-of-the-literature
#11
Daiki Goto, Naro Ohashi, Asumi Takeda, Yoshihide Fujigaki, Akira Shimizu, Hideo Yasuda, Kazuhisa Ohishi
The incidence of the collapsing variant of focal segmental glomerulosclerosis (FSGS) as a human immunodeficiency virus (HIV)-associated nephropathy has reduced since the introduction of antiretroviral therapy (ART). However, the incidence of other variants of FSGS, except for the collapsing variant, is increasing, and its therapeutic strategies remain uncertain. A 60-year-old HIV infected man in remission with ART was admitted for progressive renal insufficiency and nephrotic-ranged proteinuria. Renal biopsy revealed a tip variant of FSGS and his clinical manifestations resolved with corticosteroid therapy...
August 7, 2018: World Journal of Nephrology
https://www.readbyqxmd.com/read/30089998/biphasic-renal-synovial-sarcoma-with-extensive-venous-tumor-thrombosis-a-rare-presentation
#12
Uma Kant Dutt, Ramanathinam Manikandan, Lalgudi Narayanan Dorairajan, Bheemanathi Hanuman Srinivas
Primary renal synovial sarcoma (SS) is a very rare soft-tissue tumor arising from the kidney. These tumors histologically closely resemble other sarcoma variants. Immunohistochemical and cytogenetic techniques remain the cornerstone in achieving the correct diagnosis. Radical surgical excision is the primary treatment for local tumor control and alleviation of symptoms. Adjuvant chemotherapy, at present, has only a limited role. We report a unique case of a 21-year-old young male with the diagnosis of a biphasic renal SS with extensive venous system thrombosis involving the inferior vena cava, bilateral iliac, and femoral vessels which was managed by radical nephrectomy and tumor thrombectomy followed by adjuvant chemotherapy...
July 2018: Urology Annals
https://www.readbyqxmd.com/read/30089037/multi-parametric-mri-detects-longitudinal-evolution-of-folic-acid-induced-nephropathy-in-mice
#13
Kai Jiang, Tristan A Ponzo, Hui Tang, Prasanna K Mishra, Slobodan I Macura, Lilach O Lerman
The rodent model of folic acid (FA)-induced acute kidney injury (AKI) provides a useful model for studying human AKI, but little is known about longitudinal changes in renal hemodynamics and evolution of renal fibrosis in vivo. In this work, we aimed to longitudinally assess renal structural and functional changes using multi-parametric magnetic resonance imaging (MRI). Ten adult mice were injected with FA, after which multi-parametric MRI was used to measure kidney volume, hypoxia index R2 * , magnetization transfer ratio (MTR), perfusion, T1 , and glomerular filtration rate (GFR) at 2 weeks post-treatment...
August 8, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/30088063/renal-denervation-by-transaortic-periarterial-ethanol-injection-an-experimental-study-in-porcines
#14
Patrick Freyhardt, Josephine Schütze, Ricardo Donners, Jörg Schnorr, Nicola Stolzenburg, Jan L Rinnenthal, Tobias Penzkofer, Bernd Hamm, Rolf W Günther, Florian Streitparth
AIMS: To evaluate the feasibility, safety and efficacy of renal sympathetic denervation via endoluminal transaortic periarterial ethanol injection. METHODS AND RESULTS: In 11 normotensive pigs transaortic puncture was performed with a 90-cm 21G needle with subsequent unilateral ethanol injection to the periarterial space. Needle placement was achieved using a 7F steerable sheath fluoroscopically positioned slightly above the renal artery origin. Blood pressure measurements and abdominal CT scans were performed immediately pre- and postintervention and 4 weeks later...
August 7, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/30087584/proteomic-distinction-of-renal-oncocytomas-and-chromophobe-renal-cell-carcinomas
#15
Vanessa Drendel, Bianca Heckelmann, Christoph Schell, Lucas Kook, Martin L Biniossek, Martin Werner, Cordula A Jilg, Oliver Schilling
Background: Renal oncocytomas (ROs) are benign epithelial tumors of the kidney whereas chromophobe renal cell carcinoma (chRCCs) are malignant renal tumors. The latter constitute 5-7% of renal neoplasias. ROs and chRCCs show pronounced molecular and histological similarities, which renders their differentiation demanding. We aimed for the differential proteome profiling of ROs and early-stage chRCCs in order to better understand distinguishing protein patterns. Methods: We employed formalin-fixed, paraffin-embedded samples (six RO cases, six chRCC cases) together with isotopic triplex dimethylation and a pooled reference standard to enable cohort-wide quantitative comparison...
2018: Clinical Proteomics
https://www.readbyqxmd.com/read/30086244/phytochemical-analysis-and-nephroprotective-effect-of-cactus-opuntia-ficus-indica-cladodes-on-sodium-dichromate-induced-kidney-injury-in-rats
#16
Mbarka Hfaiedh, Dalel Brahmi, Mohamed Nizar Zourgui, Lazhar Zourgui
Environmental and occupational exposure to chromium compounds, especially hexavalent chromium, is widely recognized as potentially nephrotoxic in humans and animals. The present study aimed to assess the efficacy of cactus Opuntia ficus-indica against sodium dichromate-induced nephrotoxicity, oxidative stress and genotoxicity. The cactus cladodes extract (CCE) was phytochemically studied and tested in vitro for its potential antioxidant activities. Besides, the preventive effect of CCE upon sodium dichromate-induced renal dysfunction in Wistar albino rat model (24 rats) was evaluated...
August 7, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/30086206/facilitated-expansion-of-th17-cells-in-lupus-nephritis-patients
#17
Bogdan Jakiela, Joanna Kosałka, Hanna Plutecka, Stanisława Bazan-Socha, Marek Sanak, Jacek Musial
The objective of this study was to investigate the mechanisms of Th17 expansion in lupus nephritis (LN) patients, and determine whether it is associated with impaired function of regulatory T-cells (Treg). Major effector subsets of peripheral blood CD4+ T-cells were assessed by flow cytometry in 33 LN patients with different activity of the disease, and 19 healthy controls. Percentage of circulating Th17 cells was increased in LN (median 1.2% of CD4+ as compared to 0.6% in control group, P<0.01), while Treg cells remained unchanged (12...
August 7, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/30082017/-renal-damage-of-indium-sulfate-on-rats
#18
Linlin Zhao, Huiwen Kang, Nan Liu, Ling Xue, Jingwei Xiao, Yuping Bai, Weijun Guan, Bin Li
OBJECTIVE: To study the renal damage of indium sulfate. METHODS: 32 healthy Wistar rats were randomly and equally divided into 3 dose groups( 52. 3 mg/kg、104. 6 mg/kg 261. 4 mg/kg) and one negative control group. Indium sulfate were orally given once a day successively 5 days a week for 8 weeks. Each group of rats was collected24 hour urine after the end of the posion. We tested the content of Cr, BUN, T-AOC, ALB in serum and the GSH activity in kidney by kids and detected the β2-MG content in serum and urine by ELISA test...
May 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/30079760/contribution-of-volume-overload-to-progression-of-cardiovascular-diseases-in-rat-model-of-chronic-kidney-disease
#19
Manal Moustafa Mahmoud, Asmaa Shamseldeen, Laila Ahmed Rashed, Amal Elham Fares, Ashraf Shamaa, Doaa Mostafa Gharib
Volume overload, the common phenomenon in patients with chronic kidney disease is associated with cardiovascular risk factors.Howeverits contribution to development of adverse cardiovascular outcomes in those patients is not fully studied.Thus, the presentworkaimed to study the effect of highsalt-induced volumeoverloadin a rat model of chronic kidney disease on cardiac functions and geometry. Thirty adult male Sprague-Dawley rats were randomly divided to a sham operation anduninephrectomy, thenwere subjected to either a normal-salt (0...
August 4, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/30079088/toxicity-and-safety-evaluation-of-doxorubicin-loaded-cockleshell-derived-calcium-carbonate-nanoparticle-in-dogs
#20
Abubakar Danmaigoro, Gayathri Thevi Selvarajah, Mohd Hezmee Mohd Noor, Rozi Mahmud, Md Zuki Abu Bakar
Doxorubicin (DOX) is a potent anticancer agent with cytotoxic effects which limit its clinical usage. This effect is due to its nonselective nature causing injury to the cells as a result of reactive free oxygen radical's release. Cockleshell-derived calcium carbonate nanoparticle (CS-CaCO3 NP) is a pH-responsive carrier with targeted delivery potentials. This study aimed at evaluating the toxicity effects of repeated dose administration of DOX-loaded CS-CaCO3 NP in healthy dogs. Fifteen dogs with an average body weight of 15 kg were randomized equally into 5 groups...
2018: Advances in Pharmacological Sciences
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