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https://www.readbyqxmd.com/read/29150787/the-young-investigator-retreat-of-the-canadian-critical-care-trials-group-mentorship-and-self-discovery
#1
EDITORIAL
Ian M Ball, Lisa Burry, Peter Dodek, Jamie S Hutchison, Jeanna Parsons Leigh, Victoria McCredie, Srinivas Murthy, Bram Rochwerg, Deborah Cook
No abstract text is available yet for this article.
November 17, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29150676/severe-pollution-in-china-amplified-by-atmospheric-moisture
#2
Xuexi Tie, Ru-Jin Huang, Junji Cao, Qiang Zhang, Yafang Cheng, Hang Su, Di Chang, Ulrich Pöschl, Thorsten Hoffmann, Uli Dusek, Guohui Li, Douglas R Worsnop, Colin D O'Dowd
In recent years, severe haze events often occurred in China, causing serious environmental problems. The mechanisms responsible for the haze formation, however, are still not well understood, hindering the forecast and mitigation of haze pollution. Our study of the 2012-13 winter haze events in Beijing shows that atmospheric water vapour plays a critical role in enhancing the heavy haze events. Under weak solar radiation and stagnant moist meteorological conditions in winter, air pollutants and water vapour accumulate in a shallow planetary boundary layer (PBL)...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150535/disparities-in-management-of-cardiovascular-disease-in-rural-south-africa-data-from-the-haalsi-study-health-and-aging-in-africa-longitudinal-studies-of-international-network-for-the-demographic-evaluation-of-populations-and-their-health-communities
#3
Thiago Veiga Jardim, Sheridan Reiger, Shafika Abrahams-Gessel, Nigel J Crowther, Alisha Wade, F Xavier Gómez-Olivé, Joshua Salomon, Stephen Tollman, Thomas A Gaziano
BACKGROUND: Optimal secondary prevention is critical for the reduction of repeated cardiovascular events, and the control of cardiovascular risk factors in this context is essential. Data on secondary prevention of cardiovascular disease (CVD) in sub-Saharan Africa are needed to inform intervention strategies with a particular focus on local disparities. The aim of this study was to assess CVD management in a rural community in northeast South Africa. METHODS AND RESULTS: We recruited adults aged ≥40 years residing in the Agincourt subdistrict of Mpumalanga province...
November 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29150488/membrane-binding-of-and-a-self-inhibitory-interaction-within-nup155-are-required-for-nuclear-pore-complex-formation
#4
Paola De Magistris, Marianna Tatarek-Nossol, Manfred Dewor, Wolfram Antonin
Nuclear pore complexes (NPCs) are the gateways through the nuclear envelope. How they form into a structure containing three rings and integrate into the nuclear envelope remains a challenging paradigm for coordinated assembly of macro-complexes. In vertebrates, the cytoplasmic and nucleoplasmic rings of NPCs are mostly formed by multiple copies of the Nup107-Nup160 complex, whereas the central, or inner ring is composed of Nup53, Nup93, Nup155 and the two paralogues Nup188 and Nup205. Inner ring assembly is only partially understood...
November 17, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29149720/a-robust-strategy-for-preparation-of-sequential-stimuli-responsive-block-copolymer-prodrugs-via-thiolactone-chemistry-to-overcome-multiple-anticancer-drug-delivery-barriers
#5
Wendong Ke, Wei Yin, Zengshi Zha, Jean Felix Mukerabigwi, Weijian Chen, Yuheng Wang, Chuanxin He, Zhishen Ge
Block copolymer prodrugs (BCPs) have attracted considerable attentions in clinical translation of nanomedicine owing to their self-assembly into well-defined core-shell nanoparticles for improved pharmacokinetics, stability in blood circulation without drug leakage, and optimized biodistribution. However, a cascade of physiological barriers against specific delivery of drugs into tumor cells limit the final therapeutic efficacy. Herein, we report a robust and facile strategy based on thiolactone chemistry to fabricate well-defined BCPs with sequential tumor pH-promoted cellular internalization and intracellular stimuli-responsive drug release...
November 9, 2017: Biomaterials
https://www.readbyqxmd.com/read/29149465/controlled-sol-gel-transitions-of-a-thermoresponsive-polymer-in-a-photoswitchable-azobenzene-ionic-liquid-as-a-molecular-machine
#6
Masayoshi Watanabe, Caihong Wang, Kei Hashimoto, Ryota Tamate, Hisashi Kokubo
Producing ionic liquids (ILs) that function as molecular machines for macroscopic change is a challenging issue. We report that photoisomerization of an azobenzene IL at the molecular level could evoke a macroscopic response (light-controlled mechanical sol-gel transitions) for ABA triblock copolymer solutions. The A endblocks, poly(2-phenylethyl methacrylate), show a low critical solution temperature in the IL mixture containing azobenzene while the B midblock, poly(methyl methacrylate), is compatible with the mixture...
November 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29148790/solid-state-dewetting-of-gold-aggregates-islands-on-tio2-nanorod-structures-grown-by-oblique-angle-deposition
#7
Shizhao Liu, Joel Plawsky
A composite film made of a stable, gold nanoparticle (NP) array with well-controlled separation and size atop a TiO2 nanorod film was fabricated via the oblique angle deposition technique (OAD). The fabrication of the nanoparticle array is based on controlled, Rayleigh-instability-induced, solid-state dewetting of as-deposited gold aggregates on the TiO2 nanorods. It was found that the initial spacing between as-deposited gold aggregates along the vapor flux direction should be greater than the TiO2 inter-rod spacing created by 80° OAD in order to control the dewetting and produce NP arrays...
November 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29148735/stereoselective-stabilization-of-polymeric-vitamin-e-conjugate-micelles
#8
Min Gao, Jian Deng, Huiying Chu, Yu Tang, Zheng Wang, Yanjun Zhao, Guohui Li
Vitamin E (α-tocopherol) (TPGS) micelle is a robust nanocarrier in delivering hydrophobic active pharmaceutical ingredients, but is suffering from poor stability that is essential in terms of pharmaceutical and biomedical applications. Taking advantage of the chirality of vitamin E, this work reports the stereoselective stabilization of polymer-vitamin E conjugate micelles. Vitamin E was covalently linked to multivalent methoxy poly(ethylene glycol)-co-poly(glutamic acid), generating amphiphilic conjugates that could self-assemble into micelles...
November 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29148114/on-the-character-and-production-of-active-participation-in-neuro-rehabilitation-an-actor-network-perspective
#9
Simon Horton, Kathryn Mares, Neil Coull, Fiona Poland
The importance of patients' active involvement in neuro-rehabilitation after acquired brain injury has been consistently emphasised in recent years. However, most approaches fail to show how 'active participation' is practically enacted, focusing on individualised explanations of patient choice and behaviours, or notions of inherent patient traits. Using actor-network theory (ANT) as a sensitising concept, we investigated neuro-rehabilitation practices, asking how participation is shaped through biological and socio-material specificities, how rights to knowledge and expertise are constructed, and how a body acclimatises and adjusts within an order of participation and transformation...
November 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29148105/experiences-of-nurse-case-managers-within-a-central-discharge-planning-role-of-collaboration-between-physicians-patients-and-other-healthcare-professionals-a-sociocultural-qualitative-study
#10
Jorun E Thoma, Marion A Waite
AIMS AND OBJECTIVES: Purpose of this study was to gain knowledge of Nurse Case Managers' (NCM) experiences within the German acute care context of collaboration with patients and physicians in a discharge planning role. Further to learn about patients' assignment to the management of the NCMs. Explicitly, to explore critical incidences of interactions between NCM, patients and health care practitioner in discharge planning to understand the factor that contributes to effective collaboration...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29147950/mental-health-consultation-among-ontario-s-immigrant-populations
#11
Farah Islam, Nazilla Khanlou, Alison Macpherson, Hala Tamim
To determine the prevalence rates and characteristics of past-year mental health consultation for Ontario's adult (18 + years old) immigrant populations. The Canadian Community Health Survey (CCHS) 2012 was used to calculate the prevalence rates of past-year mental health consultation by service provider type. Characteristics associated with mental health consultation were determined by carrying out multivariable logistic regression analysis on merged CCHS 2008-2012 data. Adult immigrant populations in Ontario (n = 3995) had lower estimated prevalence rates of past-year mental health consultation across all service provider types compared to Canadian-born populations (n = 14,644)...
November 16, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/29146989/pain-dilates-time-perception
#12
Amandine E Rey, George A Michael, Corina Dondas, Marvin Thar, Luis Garcia-Larrea, Stéphanie Mazza
We have all experienced that time seems stretched during unpleasant situations. While there is evidence of subjective time overestimation when perceiving external unpleasant stimuli, no study has measured the dilation of time when individuals experience an unpleasant situation in their own body. Here we measured the time dilation induced by a painful homeostatic deviance using temporal bisection task. We show that being in pain leads to an expansion of subjective time whereby a stronger increase in pain perception relative to non-painful stimulation leads to a stronger time-estimate distortion...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29146059/oral-lymphomatoid-papulosis-type-c-a-diagnostic-pitfall-often-confused-with-t-cell-lymphoma
#13
Ziv Schwartz, Morton Coleman, Jennifer P Toyohara, Paul D Freedman, Cynthia M Magro
Eosinophilic ulcer of the oral mucosa (EUOM) is a rare, benign, self-resolving lymphoproliferative disorder, which typically presents with asymptomatic to mildly tender ulcers. Histological findings of EUOM are characterized by a polymorphic infiltrate with many eosinophils often extending into the underlying muscle. Although this entity is well documented within the dental literature, it is not well known to physicians. The pathogenesis of the condition is unclear, although reports dating back to 1997 suggest that at least a subset of EUOM represents CD30 positive lymphoproliferative disorder (CD30+ LPD)...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29145770/camptothecin-prodrug-nanomicelle-based-on-a-boronate-ester-linked-diblock-copolymer-as-the-carrier-of-doxorubicin-with-enhanced-cellular-uptake
#14
Ya Gao, Yi Xiao, Shiyuan Liu, Jiahui Yu
A novel pH-sensitive polymeric prodrug of camptothecin (CPT) by polymerizing γ-camptothecin-glutamate N-carboxyanhydride (Glu (CPT)-NCA) on boronate ester-linked poly (ethyleneglycol) (PEG) directly via the amine-initiated ring open polymerization (ROP) has been developed. The resulting amphiphilic prodrug (mPEG-BC-PGluCPT) could self-assemble into nanoparticles and encapsulate doxorubicin (Dox) simultaneously in aqueous solution for dual-drug delivery. The formation of polymeric prodrug micelles (mPEG-BC@PGluCPT) was confirmed by the measurements of critical aggregation concentration (CAC), particle size, and morphology observations...
November 17, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29145698/illicit-drug-use-illicit-drug-use-disorders-and-drug-overdose-deaths-in-metropolitan-and-nonmetropolitan-areas-united-states
#15
EDITORIAL
Karin A Mack, Christopher M Jones, Michael F Ballesteros
PROBLEM/CONDITION: Drug overdoses are a leading cause of injury death in the United States, resulting in approximately 52,000 deaths in 2015. Understanding differences in illicit drug use, illicit drug use disorders, and overall drug overdose deaths in metropolitan and nonmetropolitan areas is important for informing public health programs, interventions, and policies. REPORTING PERIOD: Illicit drug use and drug use disorders during 2003-2014, and drug overdose deaths during 1999-2015...
December 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29144733/a-mechanism-for-symmetry-breaking-and-shape-control-in-single-crystal-gold-nanorods
#16
Michael J Walsh, Wenming Tong, Hadas Katz-Boon, Paul Mulvaney, Joanne Etheridge, Alison M Funston
The phenomenon of symmetry breaking-in which the order of symmetry of a system is reduced despite manifest higher-order symmetry in the underlying fundamental laws-is pervasive throughout science and nature, playing a critical role in fields ranging from particle physics and quantum theory to cosmology and general relativity. For the growth of crystals, symmetry breaking is the crucial step required to generate a macroscopic shape that has fewer symmetry elements than the unit cell and/or seed crystal from which it grew...
November 16, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29142594/micrornas-a-subpopulation-of-regulators-are-involved-in-breast-cancer-progression-through-regulating-breast-cancer-stem-cells
#17
Xuemei Fan, Wei Chen, Ziyi Fu, Lihua Zeng, Yongmei Yin, Hongyan Yuan
Cancer stem cells (CSCs; also known as tumor-initiating cells) are essential effectors of tumor progression due to their self-renewal capacity, differentiation potential, tumorigenic ability and resistance to chemotherapy, all of which contribute to cancer relapse, metastasis and a poor prognosis. Breast cancer stem cells (BCSCs) have been identified to be involved in the processes of BC initiation, growth and recurrence. MicroRNAs (miRNAs) are a class of non-coding small RNAs of 19-23 nucleotides in length that regulate gene expression at the post-transcriptional level through various mechanisms, and serve critical roles in cancer progression...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29142376/intensive-care-nurses-attitude-on-palliative-and-end-of-life-care
#18
Swagata Tripathy, Pragyan K Routray, Jagdish C Mishra
Background: Intensive Care Unit (ICU) nurses have a vital role in the implementation of end of life (EOL) care. There is limited data on the attitude of ICU nurses toward EOL and palliation. Aim: This study aimed to investigate knowledge, attitude, and beliefs of intensive care nurses in eastern India toward EOL. Materials and Methods: A self-administered questionnaire was distributed to delegates in two regional critical care nurses' training programs...
October 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29142118/climate-and-foraging-mode-explain-interspecific-variation-in-snake-metabolic-rates
#19
Andréaz Dupoué, François Brischoux, Olivier Lourdais
The energy cost of self-maintenance is a critical facet of life-history strategies. Clarifying the determinant of interspecific variation in metabolic rate (MR) at rest is important to understand and predict ecological patterns such as species distributions or responses to climatic changes. We examined variation of MR in snakes, a group characterized by a remarkable diversity of activity rates and a wide distribution. We collated previously published MR data (n = 491 observations) measured in 90 snake species at different trial temperatures...
November 29, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29141692/the-marketing-plan-and-outcome-indicators-for-recruiting-and-retaining-parents-in-the-homestyles-randomized-controlled-trial
#20
Carol Byrd-Bredbenner, Colleen Delaney, Jennifer Martin-Biggers, Mallory Koenings, Virginia Quick
BACKGROUND: Despite the critical importance of successful recruitment and retention to study integrity, reporting of recruitment and retention strategies along with factors associated with successful recruitment and retention of participants in health-related interventions remain rare, especially for health and obesity prevention programs. Thus, the purpose of this article is to retrospectively examine the recruitment and retention marketing plan used in the online HomeStyles randomized controlled trial (RCT) and discuss outcomes associated with completion of the intervention...
November 15, 2017: Trials
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