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https://www.readbyqxmd.com/read/28550009/digital-support-interventions-for-the-self-management-of-low-back-pain-a-systematic-review
#1
Barbara I Nicholl, Louise F Sandal, Mette J Stochkendahl, Marianne McCallum, Nithya Suresh, Ottar Vasseljen, Jan Hartvigsen, Paul J Mork, Per Kjaer, Karen Søgaard, Frances S Mair
BACKGROUND: Low back pain (LBP) is a common cause of disability and is ranked as the most burdensome health condition globally. Self-management, including components on increased knowledge, monitoring of symptoms, and physical activity, are consistently recommended in clinical guidelines as cost-effective strategies for LBP management and there is increasing interest in the potential role of digital health. OBJECTIVE: The study aimed to synthesize and critically appraise published evidence concerning the use of interactive digital interventions to support self-management of LBP...
May 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28549559/the-novel-indole-3-formaldehyde-2-aitfei-3-f-is-involved-in-processes-of-apoptosis-induction
#2
Mojgan Noroozi Karimabad, Mehdi Mahmoodi, Abdollah Jafarzadeh, Ali Darehkordi, Mohammad Reza Hajizadeh, Hossein Khorramdelazad, Soudeh Khanamani Falahati-Pour, Gholamhossein Hassanshahi
AIM AND OBJECTIVES: Balancing between Bax and Bcl-2 plays critical roles in both proliferation and self-renewal activation of cancer cells. Indole-3-formaldehyde derivatives limit the growth and facilitate cell death in different cell systems. In this study, we introduced a novel indole derivative (2-AITFEI-3-F) with tendency to facilitate apoptosis in NB4 line in comparison to basal Indole-3-formaldehyde (I3F). METHODS: The NB4 cells were cultured in RPMI1640 medium contained 2-AITFEI-3-F and I3F (15...
May 23, 2017: Life Sciences
https://www.readbyqxmd.com/read/28549459/-a-steep-learning-curve-junior-doctor-perspectives-on-the-transition-from-medical-student-to-the-health-care-workplace
#3
Nancy Sturman, Zachary Tan, Jane Turner
BACKGROUND: The transition from medical student to hospital-based first year junior doctor (termed "intern" in Australia) is known to be challenging, and recent changes in clinical learning environments may reduce graduate preparedness for the intern workplace. Although manageable challenges and transitions are a stimulus to learning, levels of burnout in junior medical colleagues are concerning. In order to prepare and support medical graduates, educators need to understand contemporary junior doctor perspectives on this transition...
May 26, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28548918/palliative-care-professionals-care-and-compassion-for-self-and-others-a-narrative-review
#4
Jason Mills, Timothy Wand, Jennifer A Fraser
INTRODUCTION: Compassion is arguably central to palliative care. However, calls for the restoring of compassionate care suggest a need for greater understanding and promotion of compassion in practice. Drawing upon the Foucauldian concept 'Care of the Self', this review explored the literature relating to palliative care professionals' self-care, self-compassion, and compassion for others. METHODS: Three electronic databases were searched using identified key words...
May 2, 2017: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/28546310/heterozygous-gnal-mice-are-a-novel-animal-model-to-study-dystonia-pathophysiology
#5
Assunta Pelosi, Fabien Menardy, Daniela Popa, Jean-Antoine Girault, Denis Hervé
Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions. Its pathophysiological mechanisms are still poorly understood. Dominant mutations of the GNAL gene are a cause of isolated dystonia (DYT25) in patients. Some mutations result in a complete loss of function of the encoded protein, Gαolf, an adenylyl-cyclase-stimulatory G protein highly enriched in striatal projection neurons, in which it mediates the actions of dopamine and adenosine. We used male and female heterozygous Gnal knockout mice (Gnal+/-) to study how GNAL haplodeficiency is implicated in dystonia...
May 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28546010/cognitive-training-as-a-potential-treatment-for-overweight-and-obesity-a-critical-review-of-the-evidence-proposal-for-special-issue-in-appetite-executive-function-training-eating-behaviour
#6
REVIEW
Andrew Jones, Charlotte A Hardman, Natalia Lawrence, Matt Field
The aim of this review is to critically evaluate the effectiveness and candidate mechanisms of action of psychological interventions which aim to either (a) improve the capacity for self-regulatory, reflective processes or (b) reduce the impact of automatic appetitive processes, in an attempt to influence food intake and associated weight-gain. Our aim was to examine three important issues regarding each type of intervention: i) whether the intervention influenced behaviour in the laboratory, ii) whether the intervention influenced behaviour and/or body mass index in the real world, and iii) whether the proposed mechanism of action was supported by evidence...
May 22, 2017: Appetite
https://www.readbyqxmd.com/read/28545492/non-participants-in-policy-efforts-to-promote-evidence-based-practices-in-a-large-behavioral-health-system
#7
Rebecca E Stewart, Danielle R Adams, David S Mandell, Gayatri Nangia, Lauren Shaffer, Arthur C Evans, Ronnie Rubin, Shawna Weaver, Trevor R Hadley, Rinad S Beidas
BACKGROUND: System-wide training initiatives to support and implement evidence-based practices (EBPs) in behavioral health systems have become increasingly widespread. Understanding more about organizations who do not participate in EBP training initiatives is a critical piece of the dissemination and implementation puzzle if we endeavor to increase access in community settings. METHODS: We conducted 30 1-h semi-structured interviews with leaders in non-participating agencies who did not formally participate in system-wide training initiatives to implement EBPs in the City of Philadelphia, with the goal to understand why they did not participate...
May 25, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28545464/c10orf10-depp-mediated-ros-accumulation-is-a-critical-modulator-of-foxo3-induced-autophagy
#8
S Salcher, M Hermann, U Kiechl-Kohlendorfer, M J Ausserlechner, P Obexer
BACKGROUND: Neuroblastoma is the most common solid tumor in childhood and develops from undifferentiated progenitor cells of the sympathetic nervous system. In neuronal tumor cells DNA-damaging chemotherapeutic agents activate the transcription factor FOXO3 which regulates the formation of reactive oxygen species (ROS) and cell death as well as a longevity program associated with therapy resistance. We demonstrated before that C10ORF10/DEPP, a transcriptional target of FOXO3, localizes to peroxisomes and mitochondria and impairs cellular ROS detoxification...
May 25, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28545461/interventions-to-reduce-inequalities-in-health-and-early-child-development-in-europe-from-a-qualitative-perspective
#9
Joana Morrison, Hynek Pikhart, Peter Goldblatt
BACKGROUND: Early childhood is a critical stage of development. Inequalities in experiences affect children's wellbeing and determine their development. Early years interventions focusing on children and their parents may help address inequalities during this critical period. Understanding the experiences and perceptions of parents receiving early years programmes and staff providing these may help service development and delivery. The objective of this study was to describe staff and parents' accounts of how early childhood programmes in different European country contexts improved child development...
May 25, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28544906/development-of-a-harmonized-patient-reported-outcome-questionnaire-to-assess-myelofibrosis-symptoms-in-clinical-trials
#10
Chad Gwaltney, Jean Paty, Virginia E Kwitkowski, Ruben A Mesa, Amylou C Dueck, Elektra J Papadopoulos, Lixia Wang, Joseph Feliciano, Stephen Joel Coons
Along with reducing spleen size, relieving symptom severity is a key objective of the treatment of myelofibrosis (MF). Several questionnaires have been developed for patient self-report of MF symptoms in clinical trials and each includes unique instructions, items, and/or response scales. This variability in questionnaire content increases uncertainty; it is unclear which questionnaire is the most appropriate for assessing MF symptoms and it makes comparisons across trials difficult. The Patient-Reported Outcome (PRO) Consortium's MF Working Group (WG) was established to review existing MF symptom questionnaires and to develop a harmonized, consensus-based PRO questionnaire for use in future MF trials...
May 12, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28544436/losing-the-breast-a-meta-synthesis-of-the-impact-in-women-breast-cancer-survivors
#11
REVIEW
Lingshan Sun, Emily Ang, Wei How Daryl Ang, Violeta Lopez
OBJECTIVES: To summarize qualitative studies exploring the impact of losing the breast in women breast cancer survivors. METHODS: We identify, appraise and synthesise 12 qualitative studies from 2000 to 2015. Quality appraisal of the studies was examined using the Critical Appraisal Skill Programme Checklist and Sandelowski and Barroso's step to synthesise the findings. RESULTS: The age of women in these studies ranged from 30-77 years. Losing the breast was regarded as disfigurement resulting in a discrepancy between self and societal image of a woman...
May 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28544154/floral-nectar-of-the-obligate-outcrossing-canavalia-gladiata-jacq-dc-fabaceae-contains-only-one-predominant-protein-a-class-iii-acidic-chitinase
#12
Xue-Long Ma, Richard I Milne, Hong-Xia Zhou, Jiang-Yu Fang, Hong-Guang Zha
Floral nectar can affect the fitness of insect-pollinated plants, through both attraction and manipulation of pollinators. Self-incompatible insect-pollinated plants receive more insect visits than their self-compatible relatives, and the nectar of such species might face more risk to be infested by the pathogens carried by pollinators than self-compatible plants. Proteins in nectar (nectarins) play an important role in the protection of nectar, but little is known regarding nectarins in self-incompatible species...
May 20, 2017: Plant Biology
https://www.readbyqxmd.com/read/28543686/caring-behaviours-directly-and-indirectly-affect-nursing-students-critical-thinking
#13
Shu-Yueh Chen, Hsing-Chi Chang, Hsiang-Chu Pai
OBJECTIVES: The purpose of this study was to determine the effect of caring behaviours on critical thinking and to examine whether self-reflection mediates the effect of caring on critical thinking. We also tested whether caring behaviours moderated the relationship between self-reflection and critical thinking. METHODS: For this descriptive, correlational, cross-sectional study, we recruited 293 fifth-year nursing students from a junior college in southern Taiwan...
May 24, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28541762/chronic-stress-exposure-and-generation-are-related-to-the-p-factor-and-externalizing-specific-psychopathology-in-youth
#14
Hannah R Snyder, Jami F Young, Benjamin L Hankin
Psychopathology is posited to be transdiagnostically linked to chronic stress. Yet efforts to understand the specificity and directionality of these links have been sparse, and the ubiquitous comorbidity of psychopathology has made the seemingly nonspecific links between psychological disorders and chronic stress difficult to interpret. The current study used a latent dimensional bifactor model of psychopathology to account for comorbidity and a multiwave prospective design to disentangle temporal associations between psychopathology and chronic stress longitudinally during the critical adolescent period for psychopathology risk and stress reactivity...
May 25, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28541658/characterizing-patterned-block-copolymer-thin-films-with-soft-x-rays
#15
Daniel F Sunday, Jiaxing Ren, Christopher D Liman, Lance D Williamson, Roel Gronheid, Paul F Nealey, R Joseph Kline
The directed self-assembly (DSA) of block copolymers (BCPs) is a potential solution for patterning critical features for integrated circuits at future technology nodes. In order for this process to be implemented there needs to be a better understanding of how the template guides the assembly and induces subsurface changes in the lamellar structure. Using a rotational transmission X-ray scattering measurement coupled with soft X-rays to improve contrast between polymer components, the impact of the ratio of the guiding stripe width (W) to the BCP pitch (Lo) was investigated...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28541504/e3-ubiquitin-ligases-ubiquitous-actors-in-plant-development-and-abiotic-stress-responses
#16
Kai Shu, Wenyu Yang
Understanding the precise regulatory mechanisms of plant development and stress responses at the post-translational level is currently a topic of intensive research. Protein ubiquitination, including the sequential performances of ubiquitin-activating (E1), ubiquitin-conjugating (E2) and ubiquitin ligase (E3) enzymes, is a refined post-translational modification ubiquitous in all eukaryotes. Plants are an integral part of our ecosystem and, as sessile organisms, the ability to perceive internal and external signals and to adapt well to various environmental challenges is crucial for their survival...
May 25, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28541239/psychological-parameters-of-psoriasis
#17
A Kouris, E Platsidaki, C Kouskoukis, C Christodoulou
Psoriasis is a chronic, inflammatory scaling dermatosis. The marked visible appearance of the lesions have a negative impact on body image that leads to decreased self-esteem, hence seriously compromising the patient's quality of life. The clinical picture critically affects the social well-being of the patient since the disease is commonly misunderstood and feared by the social environment as being contagious. The patient feels stigmatized and this further intensifies their lack of self-confidence and self-esteem...
January 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28540653/il-2-and-il-15-dependent-thymic-development-of-foxp3-expressing-regulatory-t-lymphocytes
#18
REVIEW
Cécile Apert, Paola Romagnoli, Joost P M van Meerwijk
Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their differentiation requires signals from the T cell receptor for antigen, from co-stimulatory molecules, as well as from cytokine-receptors. Here we focus on the cytokines implicated in thymic development of Treg, with a particular emphasis on the roles of interleukin-2 (IL-2) and IL-15...
May 24, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28540604/systems-factorial-technology-provides-new-insights-on-the-other-race-effect
#19
Cheng-Ta Yang, Mario Fifić, Ting-Yun Chang, Daniel R Little
The other-race effect refers to the difficulty of discriminating between faces from ethnic and racial groups other than one's own. This effect may be caused by a slow, feature-by-feature, analytic process, whereas the discrimination of own-race faces occurs faster and more holistically. However, this distinction has received inconsistent support. To provide a critical test, we employed Systems Factorial Technology (Townsend & Nozawa in Journal of Mathematical Psychology, 39, 321-359, 1995), which is a powerful tool for analyzing the organization of mental networks underlying perceptual processes...
May 24, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28539651/an-orthologous-non-mhc-locus-in-rats-and-mice-is-linked-to-cd4-and-cd8-t-cell-proportion
#20
D Franckaert, R Collin, J Dooley, R H Wallis, P Poussier, A Liston, E E Hillhouse, S Lesage
CD4(+) and CD8(+) T cells have a central role in the immune system due to their ability to protect against infection and cancer development without targeting self. Consequently, changes in CD4(+) and CD8(+) T-cell homeostasis can be indicative of an array of serious illnesses, ranging from viral infections to autoimmune diseases. In addition to environmental influences, there is evidence for a genetic component regulating the proportion of CD4(+) and CD8(+) T cells in lymphoid organs. Indeed, identifying the genetic determinants defining the frequency of the T-cell subsets is critical as it may reveal a targetable genetic pathway to modulate CD4(+) and CD8(+) T-cell numbers, which could be of clinical relevance for multiple disease settings...
May 25, 2017: Genes and Immunity
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