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https://www.readbyqxmd.com/read/29792905/together-means-more-happiness-relationship-status-moderates-the-association-between-brain-structure-and-life-satisfaction
#1
Xingxing Zhu, Kangcheng Wang, Li Chen, Aihua Cao, Qunlin Chen, Junchao Li, Jiang Qiu
Life satisfaction reflects an individual's general evaluation of their overall quality of life. It has been hypothesized that relationship status (i.e. state of intimate relationship such as marriage, unmarried cohabiting, dating with others, single or divorce) may influence individual life satisfaction. However, there is little accessible empirical evidence that allows us to explore this proposition. Using a large sample of young adults (n = 1031) from the Human Connectome Project (HCP), we showed that compared to other relationship statuses (e...
May 21, 2018: Neuroscience
https://www.readbyqxmd.com/read/29792376/somatic-ace-regulates-self-renewal-of-mouse-spermatogonial-stem-cells-via-the-mapk-signaling-pathway
#2
Tingting Gao, Xin Zhao, Chenchen Liu, Binbin Shao, Xi Zhang, Kai Li, Jinyang Cai, Su Wang, Xiaoyan Huang
Spermatogonial stem cell (SSC) self-renewal is an indispensable part of spermatogenesis. Angiotensin I-converting enzyme (ACE) is a zinc dipeptidyl carboxypeptidase that plays a critical role in regulation of the renin-angiotensin system. Here, we used RT-PCR and Western blot analysis to confirm that somatic ACE (sACE) but not testicular ACE (tACE) is highly expressed in mouse testis before postpartum day 7 and in cultured SSCs. Our results revealed that sACE is located on the membrane of SSCs. Treating cultured SSCs with the ACE competitive inhibitor captopril was found to inhibit sACE activity, and significantly reduced the proliferation rate of SSCs...
May 24, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29792351/peroxiredoxin-6-inhibits-osteogenic-differentiation-and-bone-formation-through-human-dental-pulp-stem-cells-and-induces-delayed-bone-development
#3
Kyung-Ran Park, Hyung-Mun Yun, In Jun Yeo, Sehyung Cho, Jin Tae Hong, Yong Seok Jeong
AIMS: Peroxiredoxins (PRDXs) are thiol-specific antioxidant enzymes that regulate redox balance that are critical for maintaining the cellular potential for self-renewal and stemness. Stem cell-based regenerative medicine is a promising approach in tissue reconstruction. However, to obtain functional cells for use in clinical applications, stem cell technology still requires improvements. RESULTS: In the present study, we found that PRDX6 levels were decreased during osteogenic differentiation in human dental pulp stem cells (hDPSCs)...
May 24, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29791310/ways-of-knowing-as-a-framework-for-developing-reflective-practice-among-nursing-students
#4
T Diane Campbell, Kelly Penz, Marie Dietrich-Leurer, Karen Juckes, Kathy Rodger
Abstract Background:Nursing students face the challenge of developing a comprehensive understanding of the complex role of the registered nurse across various clinical settings. Frameworks such as the "ways of knowing", help students conceptualize and critically reflect upon important processes in their professional learning. However, the academic language used to describe frameworks can be challenging. PURPOSE: This manuscript has two purposes. First, to briefly describe the historical climate influencing the development of nursing as a discipline...
May 23, 2018: International Journal of Nursing Education Scholarship
https://www.readbyqxmd.com/read/29791304/common-pathways-to-nssi-and-suicide-ideation-the-roles-of-rumination-and-self-compassion
#5
Penelope Hasking, Mark E Boyes, Amy Finlay-Jones, Peter M McEvoy, Clare S Rees
OBJECTIVES: We investigated whether rumination and self-compassion moderate and/or mediate the relationships between negative affect and both non-suicidal self-injury (NSSI) and suicide ideation. METHODS: Undergraduate university students (n = 415) completed well-validated measures of negative affect, rumination, self-compassion, NSSI, and suicide ideation. RESULTS: Neither rumination nor self-compassion moderated associations between negative affect and NSSI and suicide ideation...
May 23, 2018: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/29790137/-diabetic-foot-neuropathy-and-related-factors-in-patients-with-type-2-diabetes-mellitus
#6
Tzu-Yu Chen, Chia-Huei Lin, Yue-Cune Chang, Chih-Hsin Wang, Yi-Jen Hung, Wen-Chii Tzeng
BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) face a higher risk of diabetic foot neuropathy, which increases the risk of death. The early detection of factors that influence diabetic neuropathy reduces the risk of foot lesions, including foot ulcerations, lower extremity amputation, and mortality. PURPOSE: To explore the demographic, disease-characteristic, health-literacy, and foot-self-care-behavior factors that affect diabetic foot neuropathy in patients with T2DM...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29790133/-spiritual-care-for-patients-and-their-families-in-the-intensive-care-unit
#7
Hsing-Yu Yang
To date, most of the literature in Taiwan on clinical spiritual care has focused either on improving the spiritual well-being of patients or on developing assessment tools suitable for use with end-stage cancer patients. Few articles have discussed spiritual care in the context of intensive care unit (ICU) patients and their family members. When ICU patients face life-threatening and complex physiological problems, spiritual care plays an important role in disease recovery and adaptation and impacts the satisfaction and medical decision-making of critical patients and their family members...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29789579/endogenous-authentic-oct4a-proteins-directly-regulate-fos-ap-1-transcription-in-somatic-cancer-cells
#8
Yanwen Zhou, Xinyu Chen, Bo Kang, Shiqi She, Xiaobing Zhang, Cheng Chen, Wenxin Li, Wenjie Chen, Songsong Dan, Xiaoyun Pan, Xiaoli Liu, Jianqin He, Qingwei Zhao, Chenggang Zhu, Ling Peng, Haoyi Wang, Hangping Yao, Hongcui Cao, Lanjuan Li, Meenhard Herlyn, Ying-Jie Wang
OCT4A is well established as a master transcription factor for pluripotent stem cell (PSC) self-renewal and a pioneer factor for initiating somatic cell reprogramming, yet its presence and functionality in somatic cancer cells remain controversial and obscure. By combining the CRISPR-Cas9-based gene editing with highly specific PCR assays, highly sensitive immunoassays, and mass spectrometry, we provide unequivocal evidence here that full-length authentic OCT4A transcripts and proteins were both present in somatic cancer cells, and OCT4A proteins were heterogeneously expressed in the whole cell population and when expressed, they are predominantly localized in cell nucleus...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29789350/regulatory-t-cells-and-kidney-transplantation
#9
REVIEW
Paloma Leticia Martin-Moreno, Sudipta Tripathi, Anil Chandraker
The ability of the immune system to differentiate self from nonself is critical in determining the immune response to antigens expressed on transplanted tissue. Even with conventional immunosuppression, acceptance of the allograft is an active process often determined by the presence of regulatory T cells (Tregs). Tregs classically are CD4+ cells that constitutively express high levels of the IL-2 receptor α chain CD25, along with the transcription factor Foxp3. The use of Tregs in the field of solid organ transplantation is related specifically to the objective of achieving tolerance, with the goal of reducing or eliminating immunosuppressive drugs as well as maintaining tissue repair and managing acute rejection...
May 22, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29789275/perceived-expressed-emotion-emotional-and-behavioral-problems-and-self-esteem-in-obese-adolescents-a-case-control-study
#10
Merve Çolpan, Şafak Eray, Erdal Eren, Ayşe Pınar Vural
OBJECTIVE: Obesity is a chronic disease which causes medical and psychiatric complications. Family climate is also a critical factor in the presence and treatment of obesity and comorbid psychiatric disorders. In our study, perceived expressed emotion (EE), psychopathology, self-esteem and emotional and behavioural problems among obese adolescents will be investigated by comparison with their non-obese peers. METHODS: This study was carried out with 49 obese adolescents and 47 non-obese adolescents as a control group...
May 23, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29788908/perceptions-of-insulin-use-in-type-2-diabetes-in-primary-care-a-thematic-synthesis
#11
Kathy Ellis, Henrietta Mulnier, Angus Forbes
BACKGROUND: Increasing numbers of patients with type 2 diabetes mellitus are progressing to insulin therapy, and despite its potency many such individuals still have suboptimal glycaemic control. Insulin initiation and intensification is now often conducted by Practice Nurses and General Practitioners in many parts of the UK. Therefore, gaining insight into perspectives of patients and primary care clinicians is important in determining self-management and engagement with insulin. A thematic synthesis of studies was conducted exploring the views and experiences of people with type 2 diabetes and of healthcare professionals on insulin use and management in the context of primary care...
May 22, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29788548/health-perception-and-adherence-with-blood-pressure-control-among-rural-chinese-adults-with-hypertension
#12
Lili Yang, Elizabeth Taylor, Betty Winslow, Patricia Pothier
AIM: To examine associations among blood pressure, personal and illness characteristics, illness perception and medication and self-management adherence among adults with hypertension in rural mainland China. BACKGROUND: Despite the high prevalence of hypertension in China, the control rate is only 20%. Identifying factors associated with blood pressure control is critical. DESIGN: Cross-sectional survey. METHODS: Data were collected from 163 hypertensive adults in two rural villages in mainland China...
May 22, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29788455/a-10-yr-analysis-of-chronic-pelvic-pain-and-chronic-opioid-therapy-in-the-women-veteran-population
#13
Sara B Cichowski, Rebecca G Rogers, Yuko Komesu, Erin Murata, Clifford Qualls, Allison Murata, Glen Murata
Introduction: Chronic pelvic pain (CPP) affects an estimated 30% of women Veterans. Previous research shows high rates of narcotic abuse in the women Veteran population. Narcotics are not recommended for the treatment of CPP. Understanding how CPP impacts narcotic prescribing in the women Veteran population is critical to addressing the public health crisis of opioid abuse. Our objective was to compare chronic opioid therapy (COT) prescribed 5 yr prior to and following CPP diagnosis and to identify predictors of COT as well as adverse events associated with COT...
May 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29787980/autophagy-and-mhc-restricted-antigen-presentation
#14
REVIEW
Jan Valečka, Catarina R Almeida, Bing Su, Philippe Pierre, Evelina Gatti
Major histocompatibility complex (MHC) molecules present peptide antigens to T lymphocytes and initiate immune responses. The peptides loaded onto MHC class I or MHC class II molecules can be derived from cytosolic proteins, both self and foreign. A variety of cellular processes, including endocytosis, vesicle trafficking, and autophagy, play critical roles in presentation of these antigens. We discuss the role of autophagy, a major intracellular degradation system that delivers cytoplasmic constituents to lysosomes in both MHC class I and II-restricted antigen presentation...
May 19, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29787325/barriers-to-self-reporting-patient-safety-incidents-by-paramedics-a-mixed-methods-study
#15
Julie E Sinclair, Michael A Austin, Christopher Bourque, Jennifer Kortko, Justin Maloney, Richard Dionne, Andrew Reed, Penny Price, Lisa A Calder
BACKGROUND: A minimal amount of research exists examining the extent to which patient safety events occur within paramedicine and even fewer studies investigating patient safety systems for self-reporting by paramedics. The purpose of this study was to identify barriers to paramedic self-reporting of patient safety incidents (PSIs). METHODS: We randomly distributed paper-based surveys among 1,153 paramedics in an Ontario region in Canada. The survey described one of 5 different PSI clinical scenarios (near miss, adverse event, and minor, major or critical patient care variances) and listed 18 potential barriers to self-reporting PSIs as statements presented for rating on a 5-point Likert scale (very significant = 1 - very insignificant = 5)...
May 22, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29786947/does-general-experience-affect-self-assessment
#16
Parisa Rezaiefar, Kelly Forse, Joseph K Burns, Sharon Johnston, Elizabeth Muggah, Claire Kendall, Douglas Archibald
BACKGROUND: The assessment of clinical competence is critical in medical education. Understanding the effect of general experience on a physician's self-assessment would help design more effective curricula and evaluations of procedural skills in postgraduate training and continuing professional development (CPD). In this observational study, we assessed the effect of general experience on the correlation between confidence and competence amongst experienced clinicians (ECs) and postgraduate trainees (PGTs) when learning an office-based procedure in pessary care...
May 22, 2018: Clinical Teacher
https://www.readbyqxmd.com/read/29786426/influence-of-enzyme-quantity-and-distribution-on-the-self-propulsion-of-non-janus-urease-powered-micromotors
#17
Tania Patiño, Natalia Feiner-Gracia, Xavier Arque, Albert Miguel-López, Anita Jannasch, Tom Stumpp, Erik Schäffer, Lorenzo Albertazzi, Samuel Sanchez
The use of enzyme catalysis to power micro and nanomachines offers unique features such as biocompatibility, versatili-ty and fuel bioavailability. Yet, the key parameters underlying the motion behavior of enzyme-powered motors are not completely understood. Here, we investigate the role of enzyme distribution and quantity on the generation of active mo-tion. Two different micromotor architectures based on either polystyrene (PS) or polystyrene coated with a rough silicon dioxide shell (PS@SiO2) were explored...
May 22, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29785169/self-reported-functional-communicative-and-critical-health-literacy-on-foodborne-diseases-in-accra-ghana
#18
Sangeeta Gupta, Raymond Asare Tutu, John Boateng, Janice Desire Busingye, Sathya Elavarthi
Background: Although substantial progress has been made in reducing total mortality resulting from foodborne diseases, diarrheal illness are still the second most common illnesses among children. In Ghana, foodborne diseases have consistently been among the top 20 causes of outpatient illness over the last couple of decades. This study, therefore, examines health literacy on foodborne diseases and the relative effects of health literacy on self-rated health. Methods: Foodborne diseases are major causes of morbidity and mortality globally...
2018: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29785142/misoprostol-for-the-prevention-of-postpartum-hemorrhage-during-home-births-in-rural-lao-pdr-establishing-a-pilot-program-for-community-distribution
#19
Jo Durham, Alongkone Phengsavanh, Vanphanom Sychareun, Isaac Hose, Viengnakhone Vongxay, Douangphachanh Xaysomphou, Keith Rickart
Purpose: The purpose of this study was to gather the necessary data to support the design and implementation of a pilot program for women who are unable to deliver in a healthcare facility in the Lao People's Democratic Republic (PDR), by using community distribution of misoprostol to prevent postpartum hemorrhage (PPH). The study builds on an earlier research that demonstrated both support and need for community-based distribution of misoprostol in Lao PDR. Methods: This qualitative study identified acceptability of misoprostol and healthcare system needs at varying levels to effectively distribute misoprostol to women with limited access to facility-based birthing...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29784995/an-autonomously-electrically-self-healing-liquid-metal-elastomer-composite-for-robust-soft-matter-robotics-and-electronics
#20
Eric J Markvicka, Michael D Bartlett, Xiaonan Huang, Carmel Majidi
Large-area stretchable electronics are critical for progress in wearable computing, soft robotics and inflatable structures. Recent efforts have focused on engineering electronics from soft materials-elastomers, polyelectrolyte gels and liquid metal. While these materials enable elastic compliance and deformability, they are vulnerable to tearing, puncture and other mechanical damage modes that cause electrical failure. Here, we introduce a material architecture for soft and highly deformable circuit interconnects that are electromechanically stable under typical loading conditions, while exhibiting uncompromising resilience to mechanical damage...
May 21, 2018: Nature Materials
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