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https://www.readbyqxmd.com/read/30103190/identification-of-crizotinib-derivatives-as-potent-ship2-inhibitors-for-the-treatment-of-alzheimer-s-disease
#1
Ji Woong Lim, Seok Kyu Kim, Seo Yun Choi, Dong Hoi Kim, Changdev G Gadhe, Hae Nim Lee, Hyo-Ji Kim, Jina Kim, Sung Jin Cho, Hayoung Hwang, Jihye Seong, Kyu-Sung Jeong, Jae Yeol Lee, Sang Min Lim, Jae Wook Lee, Ae Nim Pae
SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) is a lipid phosphatase that produce phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2 ) from phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3 ), and is involved in many diseases such as neurodegenerative diseases. A recent report demonstrating that SHIP2 inhibition decreased tau hyperphosphorylation induced by amyloid β and rescued memory impairment in a transgenic Alzheimer's disease mouse model indicates SHIP2 can be a promising therapeutic target for Alzheimer's disease...
August 3, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/30103164/chalcone-derivatives-from-the-root-bark-of-morus-alba-l-act-as-inhibitors-of-ptp1b-and-%C3%AE-glucosidase
#2
Manh Tuan Ha, Su Hui Seong, Tien Dat Nguyen, Won-Kyung Cho, Kim Jeong Ah, Jin Yeul Ma, Mi Hee Woo, Jae Sue Choi, Byung Sun Min
As part of our continuing research to obtain pharmacologically active compounds from Morus alba L. (Moraceae), four Diels-Alder type adducts (DAs) [morusalbins A-D], one isoprenylated flavonoid [albanin T], together with twenty-one known phenolic compounds were isolated from its root bark. The chemical structures were established using NMR, MS, and ECD spectra. The DAs including morusalbins A-D, albasin B, macrourin G, yunanensin A, mulberrofuran G and K, and albanol B exhibited strong inhibitory activities against both protein tyrosine phosphatase 1B (PTP1B) (IC50 , 1...
August 10, 2018: Phytochemistry
https://www.readbyqxmd.com/read/30103018/graft-versus-host-disease-free-relapse-free-survival-after-allogeneic-stem-cell-transplantation-for-myelodysplastic-syndrome
#3
Sung-Soo Park, Young-Woo Jeon, Gi June Min, Silvia Park, Seung-Ah Yahng, Jae-Ho Yoon, Seung-Hwan Shin, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Seok Lee, Hee-Je Kim, Chang-Ki Min, Seok-Goo Cho, Jong Wook Lee, Yoo-Jin Kim
Graft-versus-host disease-free, relapse-free survival (GRFS) is a composite endpoint that measures survival free of relapse or significant morbidity following allogeneic hematopoietic stem cell transplantation (HSCT). Consecutive 324 adult patients who received HSCT with fluarabine and busulfan based conditioning for myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia evolved from MDS were retrospectively analyzed. 1-year and 3-year GRFS rates were 47.8% and 34.5%, respectively. Three fixed factors (circulating blast >3%, high cytogenetic risk, and high comorbidity index) and two factors (which is) modifiable by clinicians [myeloablative conditioning and low-dose (<7...
August 10, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30102856/ab-initio-finite-temperature-auxiliary-field-quantum-monte-carlo
#4
Yuan Liu, Minsik Cho, Brenda Rubenstein
We present an ab initio auxiliary field quantum Monte Carlo method for studying the electronic structure of molecules, solids, and model Hamiltonians at finite temperature. The algorithm marries the ab initio phaseless auxiliary field quantum Monte Carlo algorithm known to produce high accuracy ground state energies of molecules and solids with its finite temperature variant, long used by condensed matter physicists for studying model Hamiltonian phase diagrams, to yield a phaseless, ab initio finite temperature method...
August 13, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/30102674/appropriate-amount-of-regular-exercise-is-associated-with-a-reduced-mortality-risk
#5
Da Young Lee, Eun-Jung Rhee, Jung Hwan Cho, Hyemi Kwon, Se Eun Park, Yang-Hyun Kim, Kyungdo Han, Yong-Kyu Park, Soon Jib Yoo, Won-Young Lee
PURPOSE: This study aimed at investigating whether there is a continuous dose-response relationship between the amount of physical activity (PA) and longevity benefit. METHODS: We evaluated the records of 23,257,723 Koreans aged ≥20 years who had undergone one biennial medical evaluation by the National Health Insurance Corporation. Participants with ≥20 minutes of vigorous or ≥30 minutes of moderate PA or walking were stratified into four groups: 0 days/week; 1-3 days/week; 4-5 days/week; and 6-7 days/week...
August 10, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/30102245/feedback-and-tunneling-operations-of-a-p-i-n-silicon-nanowire-field-effect-transistor
#6
Yoonjoong Kim, Doohyeok Lim, Jinsun Cho, Sangsig Kim
In this paper, we describe the feedback and tunneling operations of a dual top gate field-effect transistor (FET) with a p+-i-n+ doped silicon nanowire channel. The transistor functions selectively in either a feedback FET (FBFET) or a tunneling FET (TFET) mode by modulating the source-to-drain voltage, and it features an outstanding subthreshold swing characteristic of 6.15 mV/dec with an on/off current ratio (Ion/Ioff) of approximately 10^6 in the feedback operating mode and of 41.3 mV/dec with Ion/Ioff of ~10^7 in the tunneling operating mode...
August 13, 2018: Nanotechnology
https://www.readbyqxmd.com/read/30102146/ottowia-oryzae-sp-nov-isolated-from-andong-sikhye-a-korean-traditional-rice-beverage
#7
Jun Heo, Hayoung Cho, Seung-Beom Hong, Jeong-Seon Kim, Soon-Wo Kwon, Soo-Jin Kim
A Gram-stain-negative, non-spore-forming, non-motile, short-rod-shaped bacterial strain, designated KADR8-3T , isolated from Andong sikhye in Andong-si, Gyeongsangbuk-do, Republic of Korea, was characterized using a polyphasic approach. On the basis of morphological, genetic and chemotaxonomic characteristics, it was determined to belong to the genus Ottowia. The phylogenetic similarity based on the 16S rRNA gene sequences indicated the strain formed a clade with Ottowia beijingensis GCS-AN-3T , Ottowia thiooxydans DSM 14619T , Ottowia pentelensis RB3-7T and 'Ottowia shaoguanensis' J5-66T , showing the highest similarity to O...
August 13, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/30101910/the-prognostic-impact-of-dose-attenuated-r-chop-therapy-for-elderly-patients-with-diffuse-large-b-cell-lymphoma
#8
Akira Tanimura, Risen Hirai, Miki Nakamura, Masataka Takeshita, Shotaro Hagiwara, Akiyoshi Miwa
Objective Although R-CHOP (rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisone) is a standard therapy for diffuse large B-cell lymphoma (DLBCL), the optimal dose for elderly patients remains unclear. Methods and Patients We retrospectively verified our R-CHOP dose-attenuation system implemented from 2005 for DLBCL patients. Among the 115 DLBCL patients treated during 2001-2010, 33 patients treated during 2001-2005 received R-CHOP doses adjusted according to physicians' decisions (PHY group)...
August 10, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30100992/doxorubicin-induced-elevated-oxidative-stress-and-neurochemical-alterations-in-brain-and-cognitive-decline-protection-by-mesna-and-insights-into-mechanisms-of-chemotherapy-induced-cognitive-impairment-chemobrain
#9
Jeriel T R Keeney, Xiaojia Ren, Govind Warrier, Teresa Noel, David K Powell, Jennifer M Brelsfoard, Rukhsana Sultana, Kathryn E Saatman, Daret K St Clair, D Allan Butterfield
Chemotherapy-induced cognitive impairment (CICI) is now widely recognized as a real and too common complication of cancer chemotherapy experienced by an ever-growing number of cancer survivors. Previously, we reported that doxorubicin (Dox), a prototypical reactive oxygen species (ROS)-producing anti-cancer drug, results in oxidation of plasma proteins, including apolipoprotein A-I (ApoA-I) leading to tumor necrosis factor-alpha (TNF-α)-mediated oxidative stress in plasma and brain. We also reported that co-administration of the antioxidant drug, 2-mercaptoethane sulfonate sodium (MESNA), prevents Dox-induced protein oxidation and subsequent TNF-α elevation in plasma...
July 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/30100941/response-prediction-of-altered-thyroglobulin-levels-after-radioactive-iodine-therapy-aided-by-recombinant-human-thyrotropin-in-patients-with-differentiated-thyroid-cancer
#10
Minchul Song, Subin Jeon, Sae-Ryung Kang, Zeenat Jabin, Su Woong Yoo, Jung-Joon Min, Hee-Seung Bom, Sang-Geon Cho, Jahae Kim, Ho-Chun Song, Seong Young Kwon
Purpose: Thyroglobulin (Tg) may be released from damaged residual thyroid tissues after radioactive iodine (RAI) therapy in patients with differentiated thyroid carcinoma (DTC). We investigated whether altered levels of serum Tg after recombinant human thyrotropin (rhTSH)-aided RAI therapy could be a prognostic marker in patients with DTC. Methods: We evaluated 68 patients who underwent RAI therapy after total thyroidectomy. Serum Tg levels were measured just before RAI administration (D0Tg) and 7 days after RAI therapy (D7Tg)...
August 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30100939/emerging-tracers-for-nuclear-cardiac-pet-imaging
#11
REVIEW
Dong-Yeon Kim, Sang-Geon Cho, Hee-Seung Bom
Myocardial perfusion imaging using positron emission tomography (PET) has several advantages over single photon emission computed tomography (SPECT). The recent advances in SPECT technology have shown promise, but there is still a large need for PET in the clinical management of coronary artery disease (CAD). Especially, absolute quantification of myocardial blood flow (MBF) using PET is extremely important. In spite of considerable advances in the diagnosis of CAD, novel PET radiopharmaceuticals remain necessary for the diagnosis of CAD because clinical use of current cardiac radiotracers is limited by their physical characteristics, such as decay mode, emission energy, and half-life...
August 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30100761/applying-a-common-data-model-to-asian-databases-for-multinational-pharmacoepidemiologic-studies-opportunities-and-challenges
#12
Edward Chia-Cheng Lai, Patrick Ryan, Yinghong Zhang, Martijn Schuemie, N Chantelle Hardy, Yukari Kamijima, Shinya Kimura, Kiyoshi Kubota, Kenneth Kc Man, Soo Yeon Cho, Rae Woong Park, Paul Stang, Chien-Chou Su, Ian Ck Wong, Yea-Huei Yang Kao, Soko Setoguchi
Objective: The goal of the Asian Pharmacoepidemiology Network is to study the effectiveness and safety of medications commonly used in Asia using databases from individual Asian countries. An efficient infrastructure to support multinational pharmacoepidemiologic studies is critical to this effort. Study design and setting: We converted data from the Japan Medical Data Center database, Taiwan's National Health Insurance Research Database, Hong Kong's Clinical Data Analysis and Reporting System, South Korea's Ajou University School of Medicine database, and the US Medicare 5% sample to the Observational Medical Outcome Partnership common data model (CDM)...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/30100388/microbiocidal-characterization-of-a-novel-povidone-iodine-based-rigid-contact-lens-disinfecting-solution
#13
P Cho, S Reyes, M V Boost
This study investigated the efficacy of a novel povidone-iodine based disinfection solution for rigid gas permeable (RGP) lenses compared to three other currently available multipurpose and hydrogen peroxide solutions. Bactericidal and fungicidal activities were assessed using ISO 14729 reference methods, whilst amoebicidal properties were evaluated using an automated viability counter. All solutions were also assessed for long term storage stability over a 3-month period. The FDA guidelines were adequately achieved by all solutions tested and 3-month storage did not affect their activity against bacterial and fungal agents...
August 9, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/30100069/propranolol-increases-vascular-permeability-through-pericyte-apoptosis-and-exacerbates-oxygen-induced-retinopathy
#14
Jang-Hyuk Yun, Young Jun Koh, Han-Seok Jeong, Da-Hye Lee, Eun Hui Lee, Chung-Hyun Cho
Retinopathy of prematurity (ROP) is an eye disease that causes blindness due to delayed vascular growth, retinal ischemia, and resulting abnormal angiogenesis. Nonselective β-antagonist propranolol is in clinical trials for the treatment of ROP due to its effect of reducing VEGF expression and inhibiting retinal angiogenesis in oxygen-induced ROP models (OIR), but the mechanism by which propranolol acts on ROP vessels is still unclear. In the present study, we have focused on the effect of propranolol on pericyte survival and vascular permeability...
August 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30099842/unusual-sequelae-of-a-subluxated-primary-incisor-on-its-permanent-successor-tooth
#15
V Y Cho, R P Anthonappa, N M King
We certify that we have participated sufficiently in the intellectual content, writing this clinical report, to take public responsibility for it and have agreed to have our name listed as a contributor. Neither this manuscript nor one with substantially similar content under our authorship has been published or is being considered for publication elsewhere. This article is protected by copyright. All rights reserved.
August 12, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/30099761/upregulation-of-c-ebp%C3%AE-and-tsc2-by-an-hdac-inhibitor-cg200745-protects-heart-from-doca-induced-hypertrophy
#16
Eunjo Lee, Hae-Ahm Lee, Mina Kim, Ga Young Do, Hyun-Min Cho, Gun Jik Kim, Hanna Jung, Jung Hup Song, Joong Myung Cho, Inkyeom Kim
Histone deacetylases (HDACs) are a vast family divided into four major classes: class I (1, 2, 3, and 8), class II (4, 5, 6, 7, 9 and 10), class III (sirtuin family) and class IV (HDAC11). HDAC inhibition attenuates cardiac hypertrophy through suppression of the mechanistic target of rapamycin complex1 (mTORC1) signaling. HDAC inhibitors upregulate the expression of tuberous sclerosis complex 2 (TSC2), an mTORC1 inhibitor. However, the molecular mechanism underlying HDAC inhibitor-mediated upregulation of TSC2 is unclear...
August 12, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/30099721/a-case-of-interdigitating-dendritic-cell-sarcoma-studied-by-whole-exome-sequencing
#17
Ki Hwan Hong, Soyoung Song, Wonseok Shin, Keunsoo Kang, Chun-Sung Cho, Yong Tae Hong, Kyudong Han, Jeong Hwan Moon
Interdigitating dendritic cell sarcoma (IDCS) is an aggressive neoplasm and is an extremely rare disease, with a challenging diagnosis. Etiology of IDCS is also unknown and most studies with only case reports. In our case, immunohistochemistry showed that the tumor cells were positive for S100, CD45, and CD68, but negative for CD1a and CD21. This study aimed to investigate the causative factors of IDCS by sequencing the protein-coding regions of IDCS. We performed whole-exome sequencing with genomic DNA from blood and sarcoma tissue of the IDCS patient using the Illumina Hiseq 2500 platform...
August 11, 2018: Genes & Genomics
https://www.readbyqxmd.com/read/30099483/genome-wide-association-study-reveals-distinct-genetic-susceptibility-of-thyroid-nodules-from-thyroid-cancer
#18
Yul Hwangbo, Eun Kyung Lee, Ho-Young Son, Sun-Wha Im, Soo-Jung Kwak, Ji Won Yoon, Min Joo Kim, Jeongseon Kim, Hoon Sung Choi, Chang Hwan Ryu, You Jin Lee, Jong-Il Kim, Nam H Cho, Young Joo Park
Context: Thyroid nodules are very common and 7-15% of them are diagnosed as thyroid cancer. However, inherited genetic risk factors for thyroid nodules and their associations with thyroid cancer remain unknown. Objective: To identify genetic variants associated with susceptibility to thyroid nodules in comparison with thyroid cancer. Design and setting: We performed a three-stage genome-wide association study (GWAS) for thyroid nodules. The discovery stage involved a genome-wide scan of 811 subjects with thyroid nodules and 691 subjects with a normal thyroid from a population-based cohort...
August 6, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30099452/11%C3%AE-hydroxysteroid-dehydrogenase-type-1-inhibitor-development-by-lentiviral-screening-based-on-computational-modeling
#19
Haifeng Liu, Lingyu Li, Chunlei Zhang, Hongzhi Li, Jieting Liu, Chunyin Tang, Yufei Zhang, Dan Wu, Yanhui Chu, Yan Wu, Xiaohuan Yuan
In this study, rat and human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) have been cloned by lentiviral transduction and expressed by CHO-K1 cells. The results showed that recombinant plasmids contained R11bhsd1 or H11bhsd1 have been constructed, which is consistent with the gene bank respectively. A clone cell was selected with G418 and cultivated to express 11β-HSD1. 11β-HSD1 catalytic activity of rat and human were 99.5 and 98.7%, respectively, determined by scanning radiometer. And the cloned CHO-K1 cells expressed the protein of 11β-HSD1 in a long-term and stable manner, which makes it suitable for screening 11β-HSD1 inhibitor...
August 10, 2018: Pharmacology
https://www.readbyqxmd.com/read/30099234/a-non-synthetic-approach-to-extending-the-lifetime-of-hyperpolarized-molecules-using-d-2-o-solvation
#20
Andrew Cho, Roozbeh Eskandari, Vesselin Z Miloushev, Kayvan R Keshari
Although dissolution dynamic nuclear polarization is a robust technique to significantly increase magnetic resonance signal, the short T1 relaxation time of most 13 C-nuclei limits the timescale of hyperpolarized experiments. To address this issue, we have characterized a non-synthetic approach to extend the hyperpolarized lifetime of 13 C-nuclei in close proximity to solvent-exchangeable protons. Protons exhibit stronger dipolar relaxation than deuterium, so dissolving these compounds in D2 O to exchange labile protons with solvating deuterons results in longer-lived hyperpolarization of the 13 C-nucleus 2-bonds away...
August 2, 2018: Journal of Magnetic Resonance
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