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https://www.readbyqxmd.com/read/30102478/allergen-variability-and-house-dust-mite-sensitivity-in-pre-school-children-with-allergic-complaints
#1
Selçuk Yazıcı, Soner Güneş, Melike Kurtuluş-Çokboz, Özlem Kemer, Gülce Baranlı, Sezin Aşık-Akman, Demet Can
Yazıcı S, Güneş S, Kurtuluş-Çokboz M, Kemer Ö, Baranlı G, Aşık-Akman S, Can D. Allergen variability and house dust mite sensitivity in pre-school children with allergic complaints. Turk J Pediatr 2018; 60: 41-49. The increase in the prevalence of allergic diseases in pre-school children who are often at home may be due to an increase in house dust mite sensitivity, which is rarely expected in this age group. In our study, it was aimed to investigate allergen sensitivities, especially house dust mite sensitivity in pre-school children with allergic disease complaints by skin prick test (SPT)...
2018: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/30001632/the-dermatophagoides-pteronyssinus-molecular-sensitization-profile-of-allergic-rhinitis-patients-in-central-china
#2
Yongshi Yang, Rongfei Zhu, Nan Huang, Wenjing Li, Wei Zhang, Yin Wang, Lin Yang
Background House dust mites (HDMs) are the major aeroallergens in patients with rhinitis and/or asthma in China. However, the molecular sensitization of HDM is varied in different regions. Objective To investigate the Dermatophagoides pteronyssinus ( Der p) molecular sensitization profile of allergic rhinitis (AR) patients in Central China. Methods AR patients with positive skin prick tests to Der p were enrolled in our study. Specific immunoglobulin E (sIgE) for Der p, Dermatophagoides farinae ( Der f), Acarus siro ( Aca s), Blomia tropicalis ( Blo t), and Der p components Der p1, Der p2, and Der p10 were measured in all patients...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29992665/tropomyosins-in-mosquito-and-house-dust-mite-cross-react-at-the-humoral-and-cellular-level
#3
Jose F Cantillo, Leonardo Puerta, Enrique Fernandez-Caldas, Jose L Subiza, Irene Soria, Stefan Wöhrl, Christof Ebner, Walter Keller, Yvonne Resch-Marat, Susanne Vrtala, Barbara Bohle
BACKGROUND: Aedes aegypti and Dermatophagoides pteronyssinus contain important allergens including cross-reactive tropomyosins. However, the functional and clinical relevance of their cross-reactivity is still debated. OBJECTIVE: To analyse the humoral and cellular cross-reactivity of recombinant Aed a 10.01, Aed a 10.02 and Der p 10. METHODS: Sera from 15 Austrian house dust mite-allergic, Der p 10-sensitized individuals were tested for IgE reactivity to recombinant tropomyosins in ELISA, inhibition ELISA and basophil activation tests...
October 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29950531/comparison-of-specific-immunoglobulin-e-with-the-skin-prick-test-in-the-diagnosis-of-house-dust-mites-and-cockroach-sensitization-in-patients-with-asthma-and-or-allergic-rhinitis
#4
Suriani Alimuddin, Iris Rengganis, Cleopas M Rumende, Siti Setiati
BACKGROUND: nowadays, specific IgE measurement has been conducted in Indonesia, however there is still lack of data regarding diagnostic test to detect inhalant allergen in patients with respiratory allergies.This study aimed to determine the accuracy of specific IgE test in diagnosing specific sensitization of inhalant allergen in patients with respiratory allergies. METHODS: this was a cross sectional study in patients with respiratory allergies and part of epidemiology study regarding to specific IgE sensitization in Allergy-Immunollogy Division, Cipto Mangunkusumo Hospital, Jakarta within November-December 2016...
April 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29911320/an-open-study-on-the-efficacy-of-a-recombinant-der-f-2-dermatophagoides-farinae-immunotherapy-in-atopic-dogs-in-hungary-and-switzerland
#5
Nina Fischer, Noémi Tarpataki, Federica Leidi, Ana Rostaher, Claude Favrot
BACKGROUND: Previously published studies evaluating a recombinant Der f 2-based immunotherapy have demonstrated efficacy in the treatment of dogs experimentally and naturally sensitized to house dust mites (HDM). Der f 2 sensitization is thought to play a minor role in European atopic dogs sensitized to HDM. OBJECTIVE: The study evaluated the short-term efficacy of a recombinant Der f 2 product in the treatment of naturally sensitized atopic dogs in Switzerland and Hungary...
June 17, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29881542/cross-sectional-study-on-sensitization-to-mite-and-cockroach-allergen-components-in-allergy-patients-in-the-central-european-region
#6
Petr Panzner, Martina Vachová, Tomáš Vlas, Petra Vítovcová, Petra Brodská, Marek Malý
Background: The major sources of allergens in the indoor air include house dust mites, dander derived from domestic animals and rodents, cockroach, and several fungi. Mites are the main cause of allergies in some countries with a warmer climate, but the epidemiological significance of mite and cockroach allergens in Central Europe has not been established yet. Methods: We assessed sensitization profiles of allergy patients in a Central European region in regard to sensitization to mites and cockroach...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29422859/successful-subcutaneous-allergen-specific-immunotherapy-in-refractory-atopic-keratoconjunctivitis-a-case-report
#7
Passara Jongkhajornpong, Wannada Laisuan
Purpose: We report a case of refractory atopic keratoconjunctivitis (AKC) which was successfully treated with subcutaneous immunotherapy (SCIT). Case Report: A 22-year-old woman presented with severe allergic conjunctivitis for one and a half year. She failed to respond to conventional topical anti-allergic medications, topical corticosteroid, as well as topical cyclosporine A. Therefore, oral corticosteroids had to be prescribed to control the exacerbation for 1 year...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29279260/scabies-crusted-norwegian-scabies-and-the-diagnosis-of-mite-sensitisation
#8
REVIEW
M Sánchez-Borges, L González-Aveledo, A Capriles-Hulett, F Caballero-Fonseca
Scabies is observed with relatively high frequency in Allergy and Dermatology clinics in developing countries where poor sanitary conditions are prevalent and increasingly in some areas of the world with increased immigrant populations. Since the immunological response to scabies mites includes the production of IgE class antibodies to Sarcoptes scabiei allergens which cross-react with Dermatophagoides major allergens Der p 1 and Der p 2, positive immediate-type skin tests to house dust mite extracts should be interpreted cautiously...
May 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29198587/bedroom-allergen-exposures-in-us-households
#9
Päivi M Salo, Jesse Wilkerson, Kathryn M Rose, Richard D Cohn, Agustin Calatroni, Herman E Mitchell, Michelle L Sever, Peter J Gergen, Peter S Thorne, Darryl C Zeldin
BACKGROUND: Bedroom allergen exposures contribute to allergic disease morbidity because people spend considerable time in bedrooms, where they come into close contact with allergen reservoirs. OBJECTIVE: We investigated participant and housing characteristics, including sociodemographic, regional, and climatic factors, associated with bedroom allergen exposures in a nationally representative sample of the US population. METHODS: Data were obtained from National Health and Nutrition Examination Survey 2005-2006...
May 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29128091/non-protease-native-allergens-partially-purified-from-bodies-of-eight-domestic-mites-using-p-aminobenzamidine-ligand
#10
T Erban, R Klubal
BACKGROUND: Optimised purification steps for concentrating trace target native antigens are needed. Combining the p-aminobenzamidine ligand with protease inactivation enables partial purification of mite non-protease allergens lacking proteases. OBJECTIVE: We sought to analyse in detail proteins obtained using this method from eight species of synanthropic acaridid mites and tested IgE reactivity using pooled human sera. MATERIALS AND METHODS: Proteins affinity bound to p-aminobenzamidine as a ligand were identified by MALDI TOF/TOF...
May 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28950271/bioavailability-of-house-dust-mite-allergens-in-sublingual-allergy-tablets-is-highly-dependent-on-the-formulation
#11
Katsuyo Ohashi-Doi, Hirokazu Kito, Weibin Du, Hiroshi Nakazawa, Henrik Ipsen, Pernille Gudmann, Kaare Lund
BACKGROUND: In sublingual immunotherapy (SLIT), the immune system is addressed by solubilized allergen that interacts with immunocompetent cells of the oral mucosa, the efficiency of which is governed by 2 main factors of SLIT allergen bioavailability: the allergen concentration and the mucosal contact time. Recently, 3 house dust mite (HDM) SLIT tablets were developed that differ with regard to allergen content, nominal strength (maintenance doses: 6 SQ-HDM/10,000 Japanese Allergen Units [JAU], 12 SQ-HDM/ 20,000 JAU, and 300 IR/57,000 JAU), and formulation (freeze-dried/compressed)...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28887844/house-dust-mite-allergens-der-f-and-der-p-induce-il-31-production-by-blood-derived-t-cells-from-atopic-dermatitis-patients
#12
LETTER
Krisztina Szegedi, Amanda van Lier, Pieter C Res, Saskia Chielie, Jan D Bos, Sanja Kezic, Maritza A Middelkamp-Hup, Rosalie M Luiten
Aero-allergens, such as house dust mite (HDM), have been suggested to play a role in the initiation of atopic dermatitis (AD)-related skin inflammation. Here, we analysed the proliferation and the cytokine expression of blood-derived T cells from AD and healthy individuals upon HDM-allergen stimulation. The proliferating cells from healthy individuals and AD patients had a significantly different, distinct cytokine profile: in AD blood, we found increased frequencies of HDM-reactive IL-31-producing T cells, as well as a decreased Th1/Th2 and Tc1/Tc2 ratio, suggesting that allergen-specific T cells in blood of chronic AD patients are subject to pre-existent Th2-Tc2 and "Th31-Tc31" programming...
April 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/28835901/beneficial-effects-of-prebiotic-saccharomyces-cerevisiae-mannan-on-allergic-asthma-mouse-models
#13
D Betty Lew, Christie F Michael, Tracie Overbeck, W Scout Robinson, Erin L Rohman, Jeffrey M Lehman, Jennifer K Patel, Brandi Eiseman, Kim S LeMessurier, Amali E Samarasinghe, M Waleed Gaber
One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. The mannose receptor (MR) family plays an important role in allergen uptake and processing of major allergens Der p 1 and Fel d 1. We have previously reported that ASM cells express a mannose receptor (ASM-MR) and that mannan derived from Saccharomyces cerevisiae (SC-MN) inhibits mannosyl-rich lysosomal hydrolase-induced bovine ASM cell proliferation. Using a humanized transgenic mouse strain (huASM-MRC2) expressing the human MRC2 receptor in a SM tissue-specific manner, we have demonstrated that ASM hyperplasia/hypertrophy can occur as early as 15 days after allergen challenge in this mouse model and this phenomenon is preventable with SC-MN treatment...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28776792/a-pilot-study-of-the-effect-of-pullulan-conjugated-der-f-2-allergen-specific-immunotherapy-on-canine-atopic-dermatitis
#14
Kouji Kawano, Takuya Mizuno
BACKGROUND: Dermatophagoides farinae is a major and common environmental house dust mite involved in canine atopic dermatitis (CAD). A formulation of recombinant protein Der f 2 is available in Japan for immunotherapy in dogs. HYPOTHESIS/OBJECTIVES: To evaluate the efficacy of a recombinant allergen based on Der f 2-pullulan for the treatment of cAD. METHODS: Dogs (n = 15) with atopic dermatitis were administered Der f 2 conjugated with pullulan (-P)...
December 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28693928/the-different-modes-of-binding-of-the-dust-mite-allergens-der-f-7-and-der-p-7-on-a-monoclonal-antibody-wh9-contribute-to-the-differential-reactivity
#15
Hsiao-Yun Tai, Jia-Kai Zhou, Chang-Ching Yeh, Ming F Tam, Sheh-Yi Sheu, Horng-Der Shen
BACKGROUND: Der f 7 and Der p 7 are important house dust mite allergens. An IgE-binding inhibition monoclonal antibody WH9 reacts ten folds stronger against Der p 7 than to Der f 7. The purpose of this study is to identify the antigenic determinant(s) and the structural basis of Der f 7 recognize by WH9. METHODS: WH9-reactive determinant(s) on Der f 7 was identified by immunoblot and immunoblot inhibition. The 3-D binary complex structures of WH9 and the group 7 allergens were simulated with homology modeling and docking methods...
August 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28687424/identification-by-serological-proteome-analysis-of-paramyosin-as-prominent-allergen-in-dust-mite-allergy
#16
Antonio Conti, Giulia J Burastero, Claudia Suli, Srinita Banerjee, Susanne Vrtala, Massimo Alessio, Samuele E Burastero
Component-resolved diagnosis (CRD) of IgE-mediated hypersensitivities is challenged by the possibility that single patients are sensitized to components not commercially available to the clinical lab. Here, we studied a patient with positive extract-based diagnosis of house dust mite (HDM) allergy based on routine in vivo (prick test) and in vitro (serum specific IgE) tests, whose serum scored negative for IgE to the three recombinant allergens routinely used in CRD (group 1 allergens, group 2 allergens and tropomyosin)...
August 23, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28668244/prolonged-effect-of-allergen-sublingual-immunotherapy-for-house-dust-mites-in-elderly-patients
#17
Andrzej Bozek, Liwia Starczewska-Dymek, Jerzy Jarzab
BACKGROUND: The prolonged effect of allergen immunotherapy is unknown, especially in older patients. OBJECTIVE: To analyze the 3-year effect of sublingual allergen-specific immunotherapy (SLIT) to house dust mites in elderly patients with allergic rhinitis. METHODS: Forty-seven elderly patients (65.78 ± 4.89 years old) underwent SLIT to house dust mites and were monitored for 3 years and compared with a placebo group. SLIT was performed with the use of oral Staloral 300 SR Der p and Der f 50/50% extract (Stallergens Greer, London, United Kingdom) or placebo...
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28668242/cockroach-allergen-exposure-and-plasma-cytokines-among-children-in-a-tropical-environment
#18
Brock H Medsker, Erick Forno, Yueh-Ying Han, Edna Acosta-Pérez, Angel Colón-Semidey, Maria Alvarez, John F Alcorn, Glorisa J Canino, Juan C Celedón
BACKGROUND: Little is known about the effects of socioeconomic status or cockroach allergen on immune responses in school-age children, particularly in tropical environments. OBJECTIVE: To examine whether cockroach allergen and/or socioeconomic status is associated with plasma cytokine levels in Puerto Rican children. METHODS: This was a cross-sectional study of 532 children (6-14 years old) with (n = 272) and without (n = 260) asthma in San Juan (Puerto Rico)...
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28502519/-blomia-tropicalis-a-house-dust-mite-in-the-tropics
#19
REVIEW
L Guilleminault, C Viala-Gastan
INTRODUCTION: Blomia tropicalis is a mite that belongs to the superfamily of Glycyphagidae. Initially described as a storage mite, it is now considered as a house dust mite of tropical and sub-tropical areas. STATE OF THE ART: Sensitization to this mite is very common in South America and Southeast Asia. Epidemiological studies have also found sensitization to this mite in Africa and Central America. Blo t 5 is the major allergen of B. tropicalis. Co-sensitization to other house dust mites such as Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f) is very common...
October 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28483732/sensitivity-to-house-dust-mites-allergens-in-patients-with-allergic-asthma-in-erzincan-province-turkey
#20
Erhan Zeytun, Salih Doğan, Fatih Özçiçek, Edhem Ünver
OBJECTIVE: To investigate the sensitivity of allergic asthma (AA) patients to house dust mites (HDM) by conducting skin tests, measuring total and specific IgE antibodies to Dermatophagoides pteronyssinus and D. farinae mites, and examining HDM fauna in patients' homes. METHODS: The study included 25 patients with AA and 31 healthy controls, who were challenged with Der p and Der f allergens; serum levels of allergen-specific lgE and total IgE were measured. Dust samples were collected from the homes of all participants, and mite species and the number of mites per gram of dust were investigated...
March 2017: Türkiye Parazitolojii Dergisi
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