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https://www.readbyqxmd.com/read/30120136/work-relatedness-of-lumbosacral-radiculopathy-syndrome-review-and-dose-response-meta-analysis
#1
REVIEW
P Paul F M Kuijer, Jos H Verbeek, Andreas Seidler, Rolf Ellegast, Carel T J Hulshof, Monique H W Frings-Dresen, Henk F Van der Molen
OBJECTIVE: Clinicians need to know whether lumbosacral radiculopathy syndrome (LRS) can be attributed to work. This review describes what work-related risk factors are associated with LRS. METHODS: A systematic review was performed in PubMed and Embase. Inclusion criteria were that LRS was diagnosed by a clinician and workers exposed to work-related risk factors were compared to workers less or not exposed. A quality assessment and a meta-analysis were performed, including a dose-response analysis...
August 17, 2018: Neurology
https://www.readbyqxmd.com/read/30119108/preclinical-experience-using-a-new-robotic-system-created-for-microsurgery
#2
Tom J M van Mulken, Clint A E M Boymans, Rutger M Schols, Raimondo Cau, Ferry B F Schoenmakers, Lisette T Hoekstra, Shan S Qiu, Jesse C Selber, René R W J van der Hulst
BACKGROUND: Completing microsurgical anastomosis requires great technical skills. Robotic assistance in microsurgery can exceed the maximum human level of precision and manual dexterity to improve clinical outcomes. Since no robotic device has been designed primarily for microsurgery the authors developed a dedicated microsurgical robotic system (MSR). This preclinical study investigates whether microsurgical anastomosis can be successfully completed on silicone vessels using a prototype of this newly developed robotic system, and compares outcomes of robotic-assisted versus conventional anastomotic microsurgery...
August 9, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/30116948/treatment-of-clinically-positive-cervical-lymph-nodes-by-limited-local-node-excision-and-adjuvant-radiotherapy-in-melanoma-patients-with-major-comorbidities
#3
Hidde M Kroon, Wendy D van der Bol, Katherine T Tonks, Angela M Hong, George Hruby, John F Thompson
INTRODUCTION: When cervical lymph nodes are clinically positive for metastatic melanoma, surgeons may be hesitant to recommend a therapeutic complete lymph node dissection if the patient is elderly or has major comorbidities. A limited local node excision of the clinically positive nodes only, followed by adjuvant radiotherapy to the entire node field, may be an effective alternative in such patients. METHODS: All patients who had presented with a primary head and neck melanoma or an unknown primary site and had subsequently undergone limited local node excision and adjuvant radiotherapy for macroscopically involved cervical nodes between 1993 and 2010 at a tertiary referral center were selected for study...
August 16, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30116570/crystal-structure-of-a-dinuclear-ruthenium-ii-complex-with-a-bent-co-2-2-bridge
#4
Tsugiko Takase, Ryosuke Abe, Dai Oyama
The mol-ecular and crystal structures of a CO2 2- -bridged dinuclear ruthenium complex is reported, namely, μ-carbonito-κ2 C : O -bis-[bis(2,2'-bi-pyridine-κ2 N , N ')carbon-ylruthenium(II)] bis-(hexa-fluorido-phosphate)-aceto-nitrile-diethyl ether (1/1/0.5), [Ru2 (CO)2 (C10 H8 N2 )4 ( μ:κ 2 - C:O -CO2 )](PF6 )2 ·CH3 CN·0.5C4 H10 O. The complex cation in the title compound consists of two {Ru(CO)(bpy)2 }2+ units (bpy = 2,2'-bi-pyridine) singly bridged by a μ:κ2 - C : O carbonite anion, resulting in an unsymmetrical dinuclear structure...
August 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/30115783/shifting-the-limits-in-wheat-research-and-breeding-using-a-fully-annotated-reference-genome
#5
Rudi Appels, Kellye Eversole, Catherine Feuillet, Beat Keller, Jane Rogers, Nils Stein, Curtis J Pozniak, Nils Stein, Frédéric Choulet, Assaf Distelfeld, Kellye Eversole, Jesse Poland, Jane Rogers, Gil Ronen, Andrew G Sharpe, Curtis Pozniak, Gil Ronen, Nils Stein, Omer Barad, Kobi Baruch, Frédéric Choulet, Gabriel Keeble-Gagnère, Martin Mascher, Andrew G Sharpe, Gil Ben-Zvi, Ambre-Aurore Josselin, Nils Stein, Martin Mascher, Axel Himmelbach, Frédéric Choulet, Gabriel Keeble-Gagnère, Martin Mascher, Jane Rogers, François Balfourier, Juan Gutierrez-Gonzalez, Matthew Hayden, Ambre-Aurore Josselin, ChuShin Koh, Gary Muehlbauer, Raj K Pasam, Etienne Paux, Curtis J Pozniak, Philippe Rigault, Andrew G Sharpe, Josquin Tibbits, Vijay Tiwari, Frédéric Choulet, Gabriel Keeble-Gagnère, Martin Mascher, Ambre-Aurore Josselin, Jane Rogers, Manuel Spannagl, Frédéric Choulet, Daniel Lang, Heidrun Gundlach, Georg Haberer, Gabriel Keeble-Gagnère, Klaus F X Mayer, Danara Ormanbekova, Etienne Paux, Verena Prade, Hana Šimková, Thomas Wicker, Frédéric Choulet, Manuel Spannagl, David Swarbreck, Hélène Rimbert, Marius Felder, Nicolas Guilhot, Heidrun Gundlach, Georg Haberer, Gemy Kaithakottil, Jens Keilwagen, Daniel Lang, Philippe Leroy, Thomas Lux, Klaus F X Mayer, Sven Twardziok, Luca Venturini, Rudi Appels, Hélène Rimbert, Frédéric Choulet, Angéla Juhász, Gabriel Keeble-Gagnère, Frédéric Choulet, Manuel Spannagl, Daniel Lang, Michael Abrouk, Georg Haberer, Gabriel Keeble-Gagnère, Klaus F X Mayer, Thomas Wicker, Frédéric Choulet, Thomas Wicker, Heidrun Gundlach, Daniel Lang, Manuel Spannagl, Daniel Lang, Manuel Spannagl, Rudi Appels, Iris Fischer, Cristobal Uauy, Philippa Borrill, Ricardo H Ramirez-Gonzalez, Rudi Appels, Dominique Arnaud, Smahane Chalabi, Boulos Chalhoub, Frédéric Choulet, Aron Cory, Raju Datla, Mark W Davey, Matthew Hayden, John Jacobs, Daniel Lang, Stephen J Robinson, Manuel Spannagl, Burkhard Steuernagel, Josquin Tibbits, Vijay Tiwari, Fred van Ex, Brande B H Wulff, Curtis J Pozniak, Stephen J Robinson, Andrew G Sharpe, Aron Cory, Moussa Benhamed, Etienne Paux, Abdelhafid Bendahmane, Lorenzo Concia, David Latrasse, Jane Rogers, John Jacobs, Michael Alaux, Rudi Appels, Jan Bartoš, Arnaud Bellec, Hélène Berges, Jaroslav Doležel, Catherine Feuillet, Zeev Frenkel, Bikram Gill, Abraham Korol, Thomas Letellier, Odd-Arne Olsen, Hana Šimková, Kuldeep Singh, Miroslav Valárik, Edwin van der Vossen, Sonia Vautrin, Song Weining, Abraham Korol, Zeev Frenkel, Tzion Fahima, Vladimir Glikson, Dina Raats, Jane Rogers, Vijay Tiwari, Bikram Gill, Etienne Paux, Jesse Poland, Jaroslav Doležel, Jarmila Číhalíková, Hana Šimková, Helena Toegelová, Jan Vrána, Pierre Sourdille, Benoit Darrier, Rudi Appels, Manuel Spannagl, Daniel Lang, Iris Fischer, Danara Ormanbekova, Verena Prade, Delfina Barabaschi, Luigi Cattivelli, Pilar Hernandez, Sergio Galvez, Hikmet Budak, Burkhard Steuernagel, Jonathan D G Jones, Kamil Witek, Brande B H Wulff, Guotai Yu, Ian Small, Joanna Melonek, Ruonan Zhou, Angéla Juhász, Tatiana Belova, Rudi Appels, Odd-Arne Olsen, Kostya Kanyuka, Robert King, Kirby Nilsen, Sean Walkowiak, Curtis J Pozniak, Richard Cuthbert, Raju Datla, Ron Knox, Krysta Wiebe, Daoquan Xiang, Antje Rohde, Timothy Golds, Jaroslav Doležel, Jana Čížková, Josquin Tibbits, Hikmet Budak, Bala Ani Akpinar, Sezgi Biyiklioglu, Gary Muehlbauer, Jesse Poland, Liangliang Gao, Juan Gutierrez-Gonzalez, Amidou N'Daiye, Jaroslav Doležel, Hana Šimková, Jarmila Číhalíková, Marie Kubaláková, Jan Šafář, Jan Vrána, Hélène Berges, Arnaud Bellec, Sonia Vautrin, Michael Alaux, Françoise Alfama, Anne-Françoise Adam-Blondon, Raphael Flores, Claire Guerche, Thomas Letellier, Mikaël Loaec, Hadi Quesneville, Curtis J Pozniak, Andrew G Sharpe, Sean Walkowiak, Hikmet Budak, Janet Condie, Jennifer Ens, ChuShin Koh, Ron Maclachlan, Yifang Tan, Thomas Wicker, Frédéric Choulet, Etienne Paux, Adriana Alberti, Jean-Marc Aury, François Balfourier, Valérie Barbe, Arnaud Couloux, Corinne Cruaud, Karine Labadie, Sophie Mangenot, Patrick Wincker, Bikram Gill, Gaganpreet Kaur, Mingcheng Luo, Sunish Sehgal, Kuldeep Singh, Parveen Chhuneja, Om Prakash Gupta, Suruchi Jindal, Parampreet Kaur, Palvi Malik, Priti Sharma, Bharat Yadav, Nagendra K Singh, JitendraP Khurana, Chanderkant Chaudhary, Paramjit Khurana, Vinod Kumar, Ajay Mahato, Saloni Mathur, Amitha Sevanthi, Naveen Sharma, Ram Sewak Tomar, Jane Rogers, John Jacobs, Michael Alaux, Arnaud Bellec, Hélène Berges, Jaroslav Doležel, Catherine Feuillet, Zeev Frenkel, Bikram Gill, Abraham Korol, Edwin van der Vossen, Sonia Vautrin, Bikram Gill, Gaganpreet Kaur, Mingcheng Luo, Sunish Sehgal, Jan Bartoš, Kateřina Holušová, Ondřej Plíhal, Matthew D Clark, Darren Heavens, George Kettleborough, Jon Wright, Miroslav Valárik, Michael Abrouk, Barbora Balcárková, Kateřina Holušová, Yuqin Hu, Mingcheng Luo, Elena Salina, Nikolai Ravin, Konstantin Skryabin, Alexey Beletsky, Vitaly Kadnikov, Andrey Mardanov, Michail Nesterov, Andrey Rakitin, Ekaterina Sergeeva, Hirokazu Handa, Hiroyuki Kanamori, Satoshi Katagiri, Fuminori Kobayashi, Shuhei Nasuda, Tsuyoshi Tanaka, Jianzhong Wu, Rudi Appels, Matthew Hayden, Gabriel Keeble-Gagnère, Philippe Rigault, Josquin Tibbits, Odd-Arne Olsen, Tatiana Belova, Federica Cattonaro, Min Jiumeng, Karl Kugler, Klaus F X Mayer, Matthias Pfeifer, Simen Sandve, Xu Xun, Bujie Zhan, Hana Šimková, Michael Abrouk, Jacqueline Batley, Philipp E Bayer, David Edwards, Satomi Hayashi, Helena Toegelová, Zuzana Tulpová, Paul Visendi, Song Weining, Licao Cui, Xianghong Du, Kewei Feng, Xiaojun Nie, Wei Tong, Le Wang, Philippa Borrill, Heidrun Gundlach, Sergio Galvez, Gemy Kaithakottil, Daniel Lang, Thomas Lux, Martin Mascher, Danara Ormanbekova, Verena Prade, Ricardo H Ramirez-Gonzalez, Manuel Spannagl, Nils Stein, Cristobal Uauy, Luca Venturini, Nils Stein, Rudi Appels, Kellye Eversole, Jane Rogers, Philippa Borrill, Luigi Cattivelli, Frédéric Choulet, Pilar Hernandez, Kostya Kanyuka, Daniel Lang, Martin Mascher, Kirby Nilsen, Etienne Paux, Curtis J Pozniak, Ricardo H Ramirez-Gonzalez, Hana Šimková, Ian Small, Manuel Spannagl, David Swarbreck, Cristobal Uauy
An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue- and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development...
August 17, 2018: Science
https://www.readbyqxmd.com/read/30115656/feasibility-and-efficacy-of-addition-of-individualized-dose-lenalidomide-to-chlorambucil-and-rituximab-as-first-line-treatment-in-elderly-and-fcr-unfit-patients-with-advanced-chronic-lymphocytic-leukemia
#6
Arnon P Kater, Marinus H J van Oers, Yvette van Norden, Lina van der Straten, Julia Driessen, Ward F M Posthuma, Martinus Schipperus, Martine E D Chamuleau, Marcel Nijland, Jeanette K Doorduijn, Michel Van Gelder, Mels Hoogendoorn, Francien De Croon, Shulamiet Wittebol, J Martijn Kerst, Erik W A Marijt, Reinier A P Raymakers, Martijn R Schaafsma, Johan A Dobber, Sabina A Kersting, Mark-David Levin
BACKGROUND: Lenalidomide (Len) has been proven effective both as monotherapy and in combination with rituximab for the treatment of chronic lymphocytic leukemia (CLL). Len has shown a distinct and more difficult to manage toxicity profile in the context of CLL, potentially hampering combination treatment with this drug. METHODS: In 1st-line CLL elderly and fludarabine, cyclophosphamide, rituximab (FCR) unfit patients, we conducted a phase 1-2 study to evaluate efficacy and safety of 6 cycles of chlorambucil (7mg/m2 on days 1-7), rituximab (375mg/m2 cycle 1 and 500mg/m2 cycle 2-6) and individual dosed Len (started on day 9 of cycle 1 2...
August 16, 2018: Haematologica
https://www.readbyqxmd.com/read/30114530/the-role-of-nitrite-in-muscle-function-susceptibility-to-contraction-injury-and-fatigability-in-sickle-cell-mice
#7
Li Wang, Luis E F Almeida, Sayuri Kamimura, Jack H van der Meulen, Kanneboyina Nagaraju, Martha Quezado, Paul Wakim, Zenaide M N Quezado
Sickle cell disease (SCD) patients can have limited exercise capacity and muscle dysfunction characterized by decreased force, atrophy, microvascular abnormalities, fiber distribution changes, and skeletal muscle energetics abnormalities. Growing evidence suggests that in SCD, there is alteration in nitric oxide (NO) availability/signaling and that nitrate/nitrite can serve as a NO reservoir and enhance muscle performance. Here, we examined effects of nitrite on muscle strength, exercise capacity, and on contractile properties of fast-(extensor digitorum longus, EDL) and slow-twitch (soleus) muscles in SCD mice...
August 13, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/30112677/the-influence-of-the-configuration-of-the-c-70-2-dimer-on-its-rovibrational-spectroscopic-properties-a-theoretical-survey
#8
Rodrigo A L Silva, Sandro F de Brito, Daniel F S Machado, Valter H Carvalho-Silva, Heibbe C B de Oliveira, Luciano Ribeiro
A study of the spectroscopic properties of the buckyball dimer (C70 )2 was performed, which involved mapping the potential energy curve of this system. The spectroscopic constants of the system were obtained using theoretical Dunham and discrete variable representation methods, as well as the Rydberg analytical function expanded to the sixth degree. Because the fullerenes in the dimer have both hexagonal and pentagonal faces, the properties of (C70 )2 were examined for different system configurations. The fullerene dimerization process involves a weak interaction, possibly mediated by short-range components such as van der Waals forces...
August 15, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/30112620/a-novel-partial-volume-correction-method-for-accurate-quantification-of-18-f-flortaucipir-in-the-hippocampus
#9
Emma E Wolters, Sandeep S V Golla, Tessa Timmers, Rik Ossenkoppele, Chris W J van der Weijden, Philip Scheltens, Lothar Schwarte, Robert C Schuit, Albert D Windhorst, Frederik Barkhof, Maqsood Yaqub, Adriaan A Lammertsma, Ronald Boellaard, Bart N M van Berckel
BACKGROUND: Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18 F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). METHODS: PVC was performed on 20 [18 F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VOIs) were defined for both hippocampus and CP. The correlation between hippocampal and CP distribution volume (VT ), with and without PVC, was determined...
August 15, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/30110893/removal-of-the-n-glycosylation-sequon-at-position-n116-located-in-p27-of-the-respiratory-syncytial-virus-fusion-protein-elicits-enhanced-antibody-responses-after-dna-immunization
#10
Annelies Leemans, Marlies Boeren, Winke Van der Gucht, Isabel Pintelon, Kenny Roose, Bert Schepens, Xavier Saelens, Dalan Bailey, Wim Martinet, Guy Caljon, Louis Maes, Paul Cos, Peter Delputte
Prevention of severe lower respiratory tract infections in infants caused by the human respiratory syncytial virus (hRSV) remains a major public health priority. Currently, the major focus of vaccine development relies on the RSV fusion (F) protein since it is the main target protein for neutralizing antibodies induced by natural infection. The protein conserves 5 N-glycosylation sites, two of which are located in the F2 subunit (N27 and N70), one in the F1 subunit (N500) and two in the p27 peptide (N116 and N126)...
August 14, 2018: Viruses
https://www.readbyqxmd.com/read/30110678/heparg-progenitor-cell-derived-hepatocytes-cultured-in-bioartificial-livers-are-protected-from-healthy-and-acute-liver-failure-plasma-induced-toxicity
#11
Martien van Wenum, Philipp Treskes, Aziza A A Adam, Vincent A van der Mark, Aldo Jongejan, Perry D Moerland, Thomas M van Gulik, Ronald P J Oude Elferink, Robert A F M Chamuleau, Ruurdtje Hoekstra
BACKGROUND/AIMS: For applicability of cell-based therapies aimed at the treatment of liver failure, such as bioartificial livers (BALs) and hepatocyte transplantation, it is essential that the applied hepatocytes tolerate exposure to the patient plasma. However, plasma from both healthy donors and acute liver failure (ALF) patients is detrimental to hepatocytes and hepatic cell lines, such as HepaRG. We aimed to elucidate the underlying mechanisms of plasma-induced toxicity against HepaRG cells in order to ultimately develop methods to reduce this toxicity and render HepaRG-BAL treatment more effective...
August 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30109613/quantitative-determination-of-dna-bridging-efficiency-of-chromatin-proteins
#12
Ramon A van der Valk, Liang Qin, Geri F Moolenaar, Remus T Dame
DNA looping is important for genome organization in all domains of life. The basis of DNA loop formation is the bridging of two separate DNA double helices. Detecting DNA bridge formation generally involves the use of complex single-molecule techniques (atomic force microscopy, magnetic, or optical tweezers). Although DNA bridging can be qualitatively described, quantification of DNA bridging and bridging dynamics using these techniques is challenging. Here, we describe a novel biochemical assay capable of not only detecting DNA bridge formation, but also allowing for quantification of DNA bridging efficiency and the effects of physico-chemical conditions on DNA bridge formation...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30109483/icud-siu-international-consultation-on-bladder-cancer-2017-management-of-non-muscle-invasive-bladder-cancer
#13
REVIEW
Leonardo L Monteiro, J Alfred Witjes, Piyush K Agarwal, Christopher B Anderson, Trinity J Bivalacqua, Bernard H Bochner, Joost L Boormans, Sam S Chang, Jose L Domínguez-Escrig, James M McKiernan, Colin Dinney, Guilherme Godoy, Girish S Kulkarni, Paramananthan Mariappan, Michael A O'Donnell, Cyrill A Rentsch, Jay B Shah, Eduardo Solsona, Robert S Svatek, Antoine G van der Heijden, F Johannes P van Valenberg, Wassim Kassouf
PURPOSE: To provide a summary of the Third International Consultation on Bladder Cancer recommendations for the management of non-muscle invasive bladder cancer (NMIBC). METHODS: A detailed review of the literature was performed focusing on original articles for the management of NMIBC. An international committee assessed and graded the articles based on the Oxford Centre for Evidence-based Medicine system. The entire spectrum of NMIBC was covered such as prognostic factors of recurrence and progression, risk stratification, staging, management of positive urine cytology with negative white light cystoscopy, indications of bladder and prostatic urethral biopsies, management of Ta low grade (LG) and high risk tumors (Ta high grade [HG], T1, carcinoma in situ [CIS]), impact of BCG strain and host on outcomes, management of complications of intravesical therapy, role of alternative therapies, indications for early cystectomy, surveillance strategies, and new treatments...
August 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/30107466/infant-breastfeeding-and-childhood-general-visceral-liver-and-pericardial-fat-measures-assessed-by-magnetic-resonance-imaging
#14
Suzanne Vogelezang, Susana Santos, Eline M van der Beek, Marieke Abrahamse-Berkeveld, Liesbeth Duijts, Aad van der Lugt, Janine F Felix, Vincent W V Jaddoe
Background: Although a longer duration of breastfeeding has been associated with a lower risk of childhood obesity, the impact on specific organ fat depots is largely unknown. Objective: We examined the associations of any breastfeeding, duration and exclusiveness of breastfeeding, and of age at introduction of solid foods with measures of general, visceral, and organ adiposity at 10 y. Design: In a population-based prospective cohort study in 4444 children, we obtained information on infant feeding by questionnaires...
August 11, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30106902/few-layer-ti-3-c-2-t-x-t-o-oh-or-f-saturable-absorber-for-a-femtosecond-bulk-laser
#15
Xiaoli Sun, Baitao Zhang, Bingzheng Yan, Guoru Li, Hongkun Nie, Kejian Yang, Chengqian Zhang, Jingliang He
Few-layered titanium carbide (Ti3 C2 Tx ), a novel two-dimensional (2D) Van der Waals material in the MXene family, was fabricated with a liquid-phase method and applied as a saturable absorber for a continuous-wave mode-locked femtosecond bulk laser. Pulses as short as 316 fs with a repetition rate of 64.06 MHz and maximum output power of 0.77 W were achieved at the central wavelength of 1053.2 nm, demonstrating the first known, to the best of our knowledge, application of MXene in an all-solid-state laser...
August 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/30106185/long-term-cardiovascular-outcome-of-renal-transplant-recipients-after-early-conversion-to-everolimus-compared-to-calcineurin-inhibition-results-from-the-randomized-controlled-mecano-trial
#16
Marja van Dijk, Arie M van Roon, M Yusof Said, Frederike J Bemelman, Jaap J Homan van der Heide, Hans W de Fijter, Aiko P J de Vries, Stephan J L Bakker, Jan Stephan F Sanders
Long-term data on cardiovascular (CV) outcome of renal transplant recipients (RTR) on mTOR-i (mammalian Target Of Rapamycin-inhibitors) are scarce. In a sub-study of the MECANO trial we investigated changes in intima media thickness (IMT), CV risk profile, Major Adverse CV Events (MACE) and survival in RTR on a mTORi versus CNI based regimen. Patients (enrolled 361) were treated with (basiliximab) and triple IS (CsA-Cyclosporine A-(C), MPS(M), prednisolone(P)). At M6 patients were randomized (n=224) to the CsA group (C, P, N=89), MPS group (M, P, N=39) EVL group (Everolimus, P, N=96)...
August 14, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/30104669/two-dimensional-itinerant-ferromagnetism-in-atomically-thin-fe-3-gete-2
#17
Zaiyao Fei, Bevin Huang, Paul Malinowski, Wenbo Wang, Tiancheng Song, Joshua Sanchez, Wang Yao, Di Xiao, Xiaoyang Zhu, Andrew F May, Weida Wu, David H Cobden, Jiun-Haw Chu, Xiaodong Xu
Discoveries of intrinsic two-dimensional (2D) ferromagnetism in van der Waals (vdW) crystals provide an interesting arena for studying fundamental 2D magnetism and devices that employ localized spins1-4 . However, an exfoliable vdW material that exhibits intrinsic 2D itinerant magnetism remains elusive. Here we demonstrate that Fe3 GeTe2 (FGT), an exfoliable vdW magnet, exhibits robust 2D ferromagnetism with strong perpendicular anisotropy when thinned down to a monolayer. Layer-number-dependent studies reveal a crossover from 3D to 2D Ising ferromagnetism for thicknesses less than 4 nm (five layers), accompanied by a fast drop of the Curie temperature (TC ) from 207 K to 130 K in the monolayer...
August 13, 2018: Nature Materials
https://www.readbyqxmd.com/read/30104567/identification-of-susceptibility-pathways-for-the-role-of-chromosome-15q25-1-in-modifying-lung-cancer-risk
#18
Xuemei Ji, Yohan Bossé, Maria Teresa Landi, Jiang Gui, Xiangjun Xiao, David Qian, Philippe Joubert, Maxime Lamontagne, Yafang Li, Ivan Gorlov, Mariella de Biasi, Younghun Han, Olga Gorlova, Rayjean J Hung, Xifeng Wu, James McKay, Xuchen Zong, Robert Carreras-Torres, David C Christiani, Neil Caporaso, Mattias Johansson, Geoffrey Liu, Stig E Bojesen, Loic Le Marchand, Demetrios Albanes, Heike Bickeböller, Melinda C Aldrich, William S Bush, Adonina Tardon, Gad Rennert, Chu Chen, M Dawn Teare, John K Field, Lambertus A Kiemeney, Philip Lazarus, Aage Haugen, Stephen Lam, Matthew B Schabath, Angeline S Andrew, Hongbing Shen, Yun-Chul Hong, Jian-Min Yuan, Pier A Bertazzi, Angela C Pesatori, Yuanqing Ye, Nancy Diao, Li Su, Ruyang Zhang, Yonathan Brhane, Natasha Leighl, Jakob S Johansen, Anders Mellemgaard, Walid Saliba, Christopher Haiman, Lynne Wilkens, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Erik H F M van der Heijden, Jin Hee Kim, Juncheng Dai, Zhibin Hu, Michael P A Davies, Michael W Marcus, Hans Brunnström, Jonas Manjer, Olle Melander, David C Muller, Kim Overvad, Antonia Trichopoulou, Rosario Tumino, Jennifer Doherty, Gary E Goodman, Angela Cox, Fiona Taylor, Penella Woll, Irene Brüske, Judith Manz, Thomas Muley, Angela Risch, Albert Rosenberger, Kjell Grankvist, Mikael Johansson, Frances Shepherd, Ming-Sound Tsao, Susanne M Arnold, Eric B Haura, Ciprian Bolca, Ivana Holcatova, Vladimir Janout, Milica Kontic, Jolanta Lissowska, Anush Mukeria, Simona Ognjanovic, Tadeusz M Orlowski, Ghislaine Scelo, Beata Swiatkowska, David Zaridze, Per Bakke, Vidar Skaug, Shanbeh Zienolddiny, Eric J Duell, Lesley M Butler, Woon-Puay Koh, Yu-Tang Gao, Richard Houlston, John McLaughlin, Victoria Stevens, David C Nickle, Ma'en Obeidat, Wim Timens, Bin Zhu, Lei Song, María Soler Artigas, Martin D Tobin, Louise V Wain, Fangyi Gu, Jinyoung Byun, Ahsan Kamal, Dakai Zhu, Rachel F Tyndale, Wei-Qi Wei, Stephen Chanock, Paul Brennan, Christopher I Amos
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways...
August 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/30104426/the-repeatability-of-cognitive-performance-a-meta-analysis
#19
M Cauchoix, P K Y Chow, J O van Horik, C M Atance, E J Barbeau, G Barragan-Jason, P Bize, A Boussard, S D Buechel, A Cabirol, L Cauchard, N Claidière, S Dalesman, J M Devaud, M Didic, B Doligez, J Fagot, C Fichtel, J Henke-von der Malsburg, E Hermer, L Huber, F Huebner, P M Kappeler, S Klein, J Langbein, E J G Langley, S E G Lea, M Lihoreau, H Lovlie, L D Matzel, S Nakagawa, C Nawroth, S Oesterwind, B Sauce, E A Smith, E Sorato, S Tebbich, L J Wallis, M A Whiteside, A Wilkinson, A S Chaine, J Morand-Ferron
Behavioural and cognitive processes play important roles in mediating an individual's interactions with its environment. Yet, while there is a vast literature on repeatable individual differences in behaviour, relatively little is known about the repeatability of cognitive performance. To further our understanding of the evolution of cognition, we gathered 44 studies on individual performance of 25 species across six animal classes and used meta-analysis to assess whether cognitive performance is repeatable...
September 26, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/30102723/susceptibility-to-audio-signals-during-autonomous-driving
#20
Remo M A van der Heiden, Christian P Janssen, Stella F Donker, Lotte E S Hardeman, Keri Mans, J Leon Kenemans
We investigate how susceptible human drivers are to auditory signals in three situations: when stationary, when driving, or when being driven by an autonomous vehicle. Previous research has shown that human susceptibility is reduced when driving compared to when being stationary. However, it is not known how susceptible humans are under autonomous driving conditions. At the same time, good susceptibility is crucial under autonomous driving conditions, as such systems might use auditory signals to communicate a transition of control from the automated vehicle to the human driver...
2018: PloS One
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