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Jan Wedman, Jan Pruim, Lisa van der Putten, Otto S Hoekstra, Remco de Bree, Boukje A C van Dijk, Bernard F A M van der Laan
18F FDG PET is superior to other imaging techniques in revealing residual laryngeal cancer after radiotherapy. Unfortunately, its specificity is low, due to FDG uptake in inflammation and in anaerobic conditions. PET imaging with the amino acid-based radiopharmaceutical C11-methionine (MET) should be less influenced by post-radiation conditions. The aim of this study was to investigate the potential of MET in diagnosing recurrent laryngeal cancer after radiotherapy as compared to 18F-FDG. METHODS: Forty-eight patients with a clinical suspicion of local residual disease at least three months after completion of radiotherapy or chemoradiotherapy for a T2-4 laryngeal carcinoma, along with an indication for direct laryngoscopy, were included...
October 12, 2018: Clinical Otolaryngology
Kathelijne Cjm Kraal, Ilse Timmerman, Hannah M Kansen, Cor van den Bos, Jozsef Zsiros, Henk van den Berg, Sebastiaan F Somers, Eric Braakman, Annemarie M L Peek, Max van Noesel, C Ellen van der Schoot, Marta Fiocco, Huib N Caron, Carlijn Voermans, Godelieve A M Tytgat
PURPOSE: Targeted radiotherapy with 131 Iodine-meta-iodobenzylguanidine (131 I-MIBG) is effective for neuroblastoma (NBL), although optimal scheduling during high-risk (HR) treatment is being investigated. We aimed to evaluate the feasibility of stem cell apheresis and study hematological reconstitution after autologous stem cell transplantation (ASCT) in HR-NBL patients treated with upfront 131 I-MIBG-therapy. EXPERIMENTAL DESIGN: In two prospective multi-center cohort studies, newly diagnosed HR-NBL patients were treated with two courses of 131 I-MIBG-therapy, followed by a HR-induction protocol...
October 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Angelina M M Santoso, Jennifer E Lutomski, Cynthia S Hofman, Silke F Metzelthin, Jeanet W Blom, Philip J van der Wees, Marcel G M Olde Rikkert, René J F Melis
BACKGROUND: The Older Persons and Informal Caregivers Minimum Data Set (TOPICS-MDS) is a standardized data set that was developed to evaluate the quality of multidimensional geriatric care. There is an inherent need to reduce the number of TOPICS-MDS survey items to core outcomes to allow it to be more easily applied as a patient-reported outcome measure in clinical settings. OBJECTIVES: To create a TOPICS-short form (TOPICS-SF) and examine its validity. METHODS: Data in the TOPICS-MDS from persons aged 65 years and older in the Netherlands were used for the following analyses...
October 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Arie W Janssen
The name Cuvierina spoeli Rampal, 2002 cannot be understood as a new replacement name (nom. nov.) for Cuvierina atlantica, as published in the unavailable name Cuvierina columnella (Rang, 1827) f. atlantica van der Spoel, 1970. The name atlantica was made available as a name of the species group in the combination Cuvierina columnella atlantica Bé, MacClintock Currie, 1972, currently interpreted to represent the species Cuvierina atlantica. Cuvierina spoeli type material does not belong to C. atlantica, but to C...
August 15, 2018: Zootaxa
Emma Birnie, Theodora A M Claushuis, Gavin C K W Koh, Direk Limmathurotsakul, Nicholas P J Day, Joris J T H Roelofs, Jerry Ware, Baidong Hou, Alex F de Vos, Tom van der Poll, Cornelis van 't Veer, W Joost Wiersinga
Background: Infection with the gram-negative bacillus Burkholderia pseudomallei (melioidosis) is an important cause of pneumosepsis in Southeast Asia and has a mortality of up to 40%. We aimed to assess the role of platelets in the host response against B. pseudomallei infection. Methods: Association between platelet counts and mortality was determined in 1160 patients with culture-proven melioidosis. Mice treated with (low- or high-dose) platelet-depleting antibody were inoculated intranasally with B...
October 11, 2018: Journal of Infectious Diseases
Pieter P Lestrade, Robbert G Bentvelsen, Alexander F A D Schauwvlieghe, Steven Schalekamp, Walter J F M van der Velden, Ed J Kuiper, Judith van Paassen, Ben van der Hoven, Henrich A van der Lee, Willem J G Melchers, Anton F de Haan, Hans L van der Hoeven, Bart J A Rijnders, Martha T van der Beek, Paul E Verweij
Background: Triazole resistance is an increasing problem in invasive aspergillosis (IA). Small case series show mortality rates of 50%-100% in patients infected with a triazole-resistant Aspergillusfumigatus, but a direct comparison with triazole-susceptible IA is lacking. Methods: A 5-year retrospective cohort study (2011-2015) was conducted to compare mortality in patients with voriconazole-susceptible and voriconazole-resistant IA. Aspergillus fumigatus culture-positive patients at 3 university medical centers were investigated to identify patients with proven, probable, and putative IA...
October 11, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Marta Artola, Chi-Lin Kuo, Stephen A McMahon, Verena Oehler, Thomas Hansen, Martijn van der Lienden, Xu He, Hans van den Elst, Bogdan I Florea, Allison R Kermode, Tracey M Gloster, Gijsbert A van der Marel, Jeroen D C Codée, Hermen S Overkleeft, Johannes M F G Aerts
Cyclophellitol aziridines are potent irreversible inhibitors of retaining glycosidases and versatile intermediates in the synthesis of activity-based glycosidase probes (ABPs). Direct 3-amino-2-(trifluoromethyl)quinazolin-4(3H)-one-mediated aziridination on L-ido-configured cyclohexene has enabled the synthesis of new covalent inhibitors and ABPs of α-L-iduronidase, deficiency of which underlies the lysosomal storage disorder mucopolysaccharidosis type I (MPS I). The iduronidase ABPs react covalently and irreversibly in an activity-based manner with human recombinant α-L-iduronidase (rIDUA, Aldurazyme®)...
October 11, 2018: Chemistry: a European Journal
H F van der Molen, G J de Groene, C T J Hulshof, M H W Frings-Dresen
To support occupational physicians in their assessment and notification of occupational diseases, diagnostic registration guidelines are developed with information about associations between work-related risk factors and diseases. The objective of this review of systematic reviews is to examine whether work-related risk factors are associated with chronic pulmonary obstructive disease (COPD). We searched the electronic database of Medline for systematic reviews published between 1 January 2009 and 20 June 2017...
October 9, 2018: Journal of Clinical Medicine
F H Busanello, X Petridis, M V R So, R J B Dijkstra, S K Prashant, L W M van der Sluis
AIM: To investigate the influence of biofilm structure on the biofilm removal capacity of endodontic irrigants and to study changes in the architecture of the remaining biofilms. METHODOLOGY: Streptococcus oralis J22 and Actinomyces naeslundii T14V-J1 were co-cultured under different growth conditions on saliva-coated hydroxyapatite discs. A Constant Depth Film Fermenter (CDFF) was used to grow steady-state 4-day biofilms. Biofilms were grown under static conditions for 4 and 10 days within a confined space...
October 10, 2018: International Endodontic Journal
Annet H van Bergen, Sanne Verkooijen, Annabel Vreeker, Lucija Abramovic, Manon H Hillegers, Annet T Spijker, Erik Hoencamp, Eline J Regeer, Stefan E Knapen, Rixt F Riemersma-van der Lek, Robert Schoevers, Anja W Stevens, Peter F J Schulte, Ronald Vonk, Rocco Hoekstra, Nico J van Beveren, Ralph W Kupka, Iris E C Sommer, Roel A Ophoff, René S Kahn, Marco P M Boks
BACKGROUND: In a large and comprehensively assessed sample of patients with bipolar disorder type I (BDI), we investigated the prevalence of psychotic features and their relationship with life course, demographic, clinical, and cognitive characteristics. We hypothesized that groups of psychotic symptoms (Schneiderian, mood incongruent, thought disorder, delusions, and hallucinations) have distinct relations to risk factors. METHODS: In a cross-sectional study of 1342 BDI patients, comprehensive demographical and clinical characteristics were assessed using the Structured Clinical Interview for DSM-IV (SCID-I) interview...
October 10, 2018: Psychological Medicine
Martijn F Hoes, Nils Bomer, Peter van der Meer
Until recently, in vivo and ex vivo experiments were the only means to determine factors and pathways involved in disease pathophysiology. After the generation of characterized human embryonic stem cell lines, human diseases could readily be studied in an extensively controllable setting. The introduction of human-induced pluripotent stem cells, a decade ago, allowed the investigation of hereditary diseases in vitro. In the field of cardiology, diseases linked to known genes have successfully been studied, revealing novel disease mechanisms...
October 9, 2018: Stem Cells Translational Medicine
Wouter den Hollander, Irina Pulyakhina, Cindy Boer, Nils Bomer, Ruud van der Breggen, Wibowo Arindrarto, Rodrigo Couthino de Almeida, Nico Lakenberg, Thom Sentner, Jeroen F J Laros, Peter A C 't Hoen, Eline P E Slagboom, Rob G H H Nelissen, Joyce van Meurs, Yolande F M Ramos, Ingrid Meulenbelt
OBJECTIVES: Multiple osteoarthritis (OA) susceptibility single nucleotide polymorphisms (SNPs) mark imbalanced expression of positional genes in articular cartilage, reflected by unequally expressed alleles among heterozygotes (allelic imbalance, AI). Here, we explored the articular cartilage transcriptome from OA patients for AI events to identify putative disease driving genetic variation. METHODS: AI was assessed in N=42 preserved and N=5 lesioned OA cartilage samples (RAAK-study) for which RNA sequencing data was available...
October 9, 2018: Arthritis & Rheumatology
Katinka R van Kranendonk, Kilian M Treurniet, Anna M M Boers, Olvert A Berkhemer, Lucie A van den Berg, Vicky Chalos, Hester F Lingsma, Wim H van Zwam, Aad van der Lugt, Robert J van Oostenbrugge, Diederik W J Dippel, Yvo B W E M Roos, Henk A Marquering, Charles B L M Majoie
BACKGROUND AND PURPOSE: Hemorrhagic transformation (HT) is a complication that may cause neurological deterioration in patients with acute ischemic stroke. Various radiological subtypes of HT can be distinguished. Their influence on functional outcome is currently unclear. The purpose of this study was to assess the associations between HT subtypes and functional outcome in acute ischemic stroke patients with proven large vessel occlusion included in the MR CLEAN trial (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic stroke in The Netherlands)...
October 8, 2018: Journal of Neurointerventional Surgery
Henk F van der Molen, Carel Tj Hulshof, P Paul Fm Kuijer
OBJECTIVE: To explore the impact of occupational diseases (ODs) through estimations of population attributable fractions (PAFs) in a national context. METHODS: PAFs were calculated for eight prevalent ODs using existing data on the prevalence of exposure to risk factors at work and the strength of their association with diseases based on systematic reviews. Six systematic reviews with meta-analyses and two overview papers were selected. All addressed the relationship between occupational exposure to work-related risk factors for these eight prevalent ODs...
October 8, 2018: Occupational and Environmental Medicine
J A van der Sluijs, M J van der Sluijs, F van de Bunt, W J R van Ouwerkerk
Purpose: As in other neuromuscular disorders, both denervation and muscle paresis/imbalance are implicated as aetiological factors for contractures in children with a Brachial Plexus Birth Injury (BPBI). Although both factors are related, it is unclear which factor is dominant. The aim of this study is to assess whether contracture formation in children is predominantly related to denervation or to residual muscle function/imbalance. This might be relevant for understanding contracture formation in other neuromuscular disorders...
October 1, 2018: Journal of Children's Orthopaedics
Jorge Domínguez-Andrés, Boris Novakovic, Yang Li, Brendon P Scicluna, Mark S Gresnigt, Rob J W Arts, Marije Oosting, Simone J C F M Moorlag, Laszlo A Groh, Jelle Zwaag, Rebecca M Koch, Rob Ter Horst, Leo A B Joosten, Cisca Wijmenga, Alessandro Michelucci, Tom van der Poll, Matthijs Kox, Peter Pickkers, Vinod Kumar, Henk Stunnenberg, Mihai G Netea
Sepsis involves simultaneous hyperactivation of the immune system and immune paralysis, leading to both organ dysfunction and increased susceptibility to secondary infections. Acute activation of myeloid cells induced itaconate synthesis, which subsequently mediated innate immune tolerance in human monocytes. In contrast, induction of trained immunity by β-glucan counteracted tolerance induced in a model of human endotoxemia by inhibiting the expression of immune-responsive gene 1 (IRG1), the enzyme that controls itaconate synthesis...
October 1, 2018: Cell Metabolism
Kees van der Wulp, Michel W A Verkroost, Marleen H van Wely, Helmut R Gehlmann, Leen A F M Van Garsse, L Noyez, Marc A Brouwer, Peter C Kievit, Menko-Jan De Boer, Harry Suryapranata, Wim J Morshuis, Niels van Royen
BACKGROUND: The femoral artery is generally used as primary access for TAVI. However, peripheral artery disease often precludes femoral access. The purpose of this study was to describe clinical outcome of TAVI using the left axillary artery (LAA) as primary access site. METHODS: From December 2008 until June 2016, data on all consecutive patients treated with a Medtronic device via the LAA at our hospital were registered and outcome was prospectively collected according to the updated VARC-2 criteria...
October 4, 2018: Annals of Thoracic Surgery
Evie van der Spoel, Nicole Oei, Ricardo Cachucho, Ferdinand Roelfsema, Jimmy F P Berbée, Gerard J Blauw, Hanno Pijl, Natasha M Appelman-Dijkstra, Diana van Heemst
The process of bone turnover displays variations over 24 h, with C-terminal cross-linked telopeptide of type 1 collagen (CTX) and osteocalcin exhibiting a nadir in the afternoon and a peak in the night. In contrast, N-terminal propeptide of type 1 procollagen (P1NP) did not display an apparent 24-hour rhythm. Other emerging novel biomarkers of bone, sclerostin and Dickkopf-related protein 1 (DKK1), are markers of osteocyte activity with limited data available regarding their 24-hour profiles. In this study, we aimed to extend available data on 24-hour profiles of CTX, osteocalcin, and P1NP and to assess the 24-hour profiles of sclerostin and DKK1 in healthy older men and women and to compare these between men and women...
October 4, 2018: Bone
Floris F van den Brand, Koen S van der Veen, Ynto S de Boer, Nicole M van Gerven, Birgit I Lissenberg-Witte, Ulrich Beuers, Karel J van Erpecum, Henk R van Buuren, Jannie W den Ouden, Johannus T Brouwer, Jan M Vrolijk, Robert C Verdonk, Bart van Hoek, Ger H Koek, Joost P H Drenth, Marleen M J Guichelaar, Chris J J Mulder, Elisabeth Bloemena, Carin M J van Nieuwkerk, Gerd Bouma
BACKGROUND & AIMS: There have been few reproducible studies of mortality in patients with autoimmune hepatitis (AIH) and its variants. We calculated mortality in a large national cohort of patients with AIH, with vs without cirrhosis, in the Netherlands. METHODS: We collected data from 449 patients with established AIH (77% female), from 6 academic and 10 non-academic hospitals in the Netherlands. We identified 29 patients with AIH and primary biliary cholangitis and 35 patients with AIH and primary sclerosing cholangitis (AIH-PSC)...
October 3, 2018: Clinical Gastroenterology and Hepatology
J F W Rikken, C R Kowalik, M H Emanuel, M Y Bongers, T Spinder, J H de Kruif, K W M Bloemenkamp, F W Jansen, S Veersema, A G M G J Mulders, A L Thurkow, K Hald, A Mohazzab, Y Khalaf, T J Clark, M Farrugia, H A van Vliet, M S Stephenson, F van der Veen, M van Wely, B W J Mol, M Goddijn
BACKGROUND: A septate uterus is a uterine anomaly that may affect reproductive outcome, and is associated with an increased risk for miscarriage, subfertility and preterm birth. Resection of the septum is subject of debate. There is no convincing evidence concerning its effectiveness and safety. This study aims to assess whether hysteroscopic septum resection improves reproductive outcome in women with a septate uterus. METHODS/DESIGN: A multi-centre randomised controlled trial comparing hysteroscopic septum resection and expectant management in women with recurrent miscarriage or subfertility and diagnosed with a septate uterus...
October 5, 2018: BMC Women's Health
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