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https://www.readbyqxmd.com/read/29644894/decreased-epithelial-and-sputum-mir-221-3p-associates-with-airway-eosinophilic-inflammation-and-cxcl17-expression-in-asthma
#1
Kan Zhang, Yuxia Liang, Yuchen Feng, Wenliang Wu, Huilan Zhang, Jianguo He, Qinghua Hu, Jian-Ping Zhao, Yongjian Xu, Zheng Liu, Guohua Zhen
Airway eosinophilic inflammation is a key feature of type 2-high asthma. The role of epithelial miRNA in airway eosinophilic inflammation remains unclear. We examined the expression of miR-221-3p in bronchial brushings, induced sputum and plasma from 77 symptomatic, recently diagnosed steroid-naïve subjects with asthma and 36 healthy controls by quantitative PCR, and analyzed the correlation between miR-221-3p expression and airway eosinophilia. We found that epithelial, sputum and plasma miR-221-3p expression was significantly decreased in subjects with asthma...
April 12, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29424082/a-microrna-1-gene-tci-mir-1-3p-is-involved-in-cyflumetofen-resistance-by-targeting-a-glutathione-s-transferase-gene-tcgstm4-in-tetranychus-cinnabarinus
#2
Y Zhang, K Feng, J Hu, L Shi, P Wei, Z Xu, G Shen, M Li, Q Xu, L He
microRNA-1 (miR-1) is a well-studied conservative microRNA (miRNA) involved in immune responses in mammals and insects. However, little is known about its role in pesticide resistance in arthropods. In this study, we found that a microRNA belong to miR-1 family (tci-miR-1-3p) was significantly down-regulated in a cyflumetofen-resistant strain (CYR) of Tetranychus cinnabarinus compared with its homologous susceptible strain (SS), indicating an involvement of miR-1 in cyflumetofen resistance in mites. One glutathione S-transferase (GST) gene (TCGSTM4, a mu class GST gene), a candidate target gene of tci-miR-1-3p, was found to be significantly down-regulated when tci-miR-1-3p was over-expressed...
June 2018: Insect Molecular Biology
https://www.readbyqxmd.com/read/28859242/selective-release-of-mirnas-via-extracellular-vesicles-is-associated-with-house-dust-mite-allergen-induced-airway-inflammation
#3
Y Gon, S Maruoka, T Inoue, K Kuroda, K Yamagishi, Y Kozu, S Shikano, K Soda, J Lötvall, S Hashimoto
BACKGROUND: MicroRNAs (miRNAs) may facilitate cell-to-cell communication via extracellular vesicles (EVs). The biological roles of miRNAs in EVs on allergic airway inflammation are unclear. METHODS: Airway-secreted EVs (AEVs) were isolated from bronchoalveolar lavage fluid (BALF) of control and house-dust mite (HDM) allergen-exposed HDM-sensitized mice. The expression of miRNAs in AEVs or miRNAs and mRNAs in lung tissue was analysed using miRNA microarray. RESULTS: The amount of AEV increased 8...
December 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28513859/identification-of-a-plasma-mirna-biomarker-signature-for-allergic-asthma-a-translational-approach
#4
K Milger, J Götschke, L Krause, P Nathan, F Alessandrini, A Tufman, R Fischer, S Bartel, F J Theis, J Behr, S Dehmel, N S Mueller, N Kneidinger, S Krauss-Etschmann
BACKGROUND: Asthma is a heterogeneous chronic disease with different phenotypes and treatment responses. Thus, there is a high clinical need for molecular disease biomarkers to aid in differentiating these distinct phenotypes. As MicroRNAs (miRNAs), that regulate gene expression at the post-transcriptional level, are altered in experimental and human asthma, circulating miRNAs are attractive candidates for the identification of novel biomarkers. This study aimed to identify plasmatic miRNA-based biomarkers of asthma, through a translational approach...
December 2017: Allergy
https://www.readbyqxmd.com/read/28383034/pulmonary-microrna-profiles-identify-involvement-of-creb1-and-sec14l3-in-bronchial-epithelial-changes-in-allergic-asthma
#5
Sabine Bartel, Nikola Schulz, Francesca Alessandrini, Andrea C Schamberger, Philipp Pagel, Fabian J Theis, Katrin Milger, Elfriede Noessner, Stephen M Stick, Anthony Kicic, Oliver Eickelberg, Robert J Freishtat, Susanne Krauss-Etschmann
Asthma is highly prevalent, but current therapies cannot influence the chronic course of the disease. It is thus important to understand underlying early molecular events. In this study, we aimed to use microRNAs (miRNAs) - which are critical regulators of signaling cascades - to identify so far uncharacterized asthma pathogenesis pathways. Therefore, deregulation of miRNAs was assessed in whole lungs from mice with ovalbumin (OVA)-induced allergic airway inflammation (AAI). In silico predicted target genes were confirmed in reporter assays and in house-dust-mite (HDM) induced AAI and primary human bronchial epithelial cells (NHBE) cultured at the air-liquid interface...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27913727/regulated-complex-assembly-safeguards-the-fidelity-of-sleeping-beauty-transposition
#6
Yongming Wang, Diana Pryputniewicz-Dobrinska, Enikö Éva Nagy, Christopher D Kaufman, Manvendra Singh, Steve Yant, Jichang Wang, Anna Dalda, Mark A Kay, Zoltán Ivics, Zsuzsanna Izsvák
The functional relevance of the inverted repeat structure (IR/DR) in a subgroup of the Tc1/mariner superfamily of transposons has been enigmatic. In contrast to mariner transposition, where a topological filter suppresses single-ended reactions, the IR/DR orchestrates a regulatory mechanism to enforce synapsis of the transposon ends before cleavage by the transposase occurs. This ordered assembly process shepherds primary transposase binding to the inner 12DRs (where cleavage does not occur), followed by capture of the 12DR of the other transposon end...
January 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27277384/regulation-of-cbl-and-esr1-expression-by-microrna-22%C3%A2-3p-513a-5p-and-625-5p-may-impact-the-pathogenesis-of-dust-mite-induced-pediatric-asthma
#7
Xiaoyan Dong, Miao Xu, Zhaorui Ren, Jianlei Gu, Min Lu, Quan Lu, Nanbert Zhong
Despite evidence for the involvement of microRNAs (miRNAs or miRs) in pediatric asthma, the mechanism responsible has not yet been fully elucidated. We aimed to identify novel miRNAs and to study their pathogenic role(s) in children with dust mite-induced asthma in order to gain a better understanding of the underlying mechanism responsible for this disease. For this purpose, 62 patients with asthma as well as 62 age- and gender-matched healthy controls were recruited. Twelve pairs of subjects were randomly subjected to microarray-based discovery analysis using a miRCURY LNA™ array...
August 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27160169/genome-wide-characterization-and-evolution-analysis-of-miniature-inverted-repeat-transposable-elements-mites-in-moso-bamboo-phyllostachys-heterocycla
#8
Mingbing Zhou, Guiyun Tao, Peiyao Pi, Yihang Zhu, Youhuang Bai, Xianwen Meng
Moso bamboo MITEs were genome-wide identified first time, and data shows that MITEs contribute to the genomic diversity and differentiation of bamboo. Miniature inverted-repeat transposable elements (MITEs) are widespread in animals and plants. There are a large number of transposable elements in moso bamboo (Phyllostachys heterocycla var. pubescens) genome, but the genome-wide information of moso bamboo MITEs is not known yet. Here we identified 362 MITE families with a total of 489,592 MITE-related sequences, accounting for 4...
October 2016: Planta
https://www.readbyqxmd.com/read/27050424/identification-of-differentially-expressed-micrornas-between-the-fenpropathrin-resistant-and-susceptible-strains-in-tetranychus-cinnabarinus
#9
Yichao Zhang, Zhifeng Xu, Qiong Wu, Miao Peng, Yanchao Liu, Xing Liu, Li Shi, Guangmao Shen, Yu Pan, Lin He
The carmine spider mite (Tetranychus cinnabarinus) is one of the most serious pests on crops and its control mainly depends on chemical acaricides. The excessive and improper acaricides use has resulted in mite resistance to many acaricides, including fenpropathrin. Previous studies have indicated fenpropathrin resistance is a complex development process involving many genes, but information on resistance mechanism of post-transcription regulation is rare. Using Illumina sequencing, several categories of sRNAs were identified from susceptible (TS) and fenpropathrin-resistant strains (TR) of T...
2016: PloS One
https://www.readbyqxmd.com/read/26464523/transcriptome-wide-investigation-of-circular-rnas-in-rice
#10
Tingting Lu, Lingling Cui, Yan Zhou, Chuanrang Zhu, Danlin Fan, Hao Gong, Qiang Zhao, Congcong Zhou, Yan Zhao, Danfeng Lu, Jianghong Luo, Yongchun Wang, Qilin Tian, Qi Feng, Tao Huang, Bin Han
Various stable circular RNAs (circRNAs) are newly identified to be the abundance of noncoding RNAs in Archaea, Caenorhabditis elegans, mice, and humans through high-throughput deep sequencing coupled with analysis of massive transcriptional data. CircRNAs play important roles in miRNA function and transcriptional controlling by acting as competing endogenous RNAs or positive regulators on their parent coding genes. However, little is known regarding circRNAs in plants. Here, we report 2354 rice circRNAs that were identified through deep sequencing and computational analysis of ssRNA-seq data...
December 2015: RNA
https://www.readbyqxmd.com/read/26303911/identification-of-micrornas-associated-with-allergic-airway-disease-using-a-genetically-diverse-mouse-population
#11
Holly Rutledge, Jeanette Baran-Gale, Fernando Pardo-Manuel de Villena, Elissa J Chesler, Gary A Churchill, Praveen Sethupathy, Samir N P Kelada
BACKGROUND: Allergic airway diseases (AADs) such as asthma are characterized in part by granulocytic airway inflammation. The gene regulatory networks that govern granulocyte recruitment are poorly understood, but evidence is accruing that microRNAs (miRNAs) play an important role. To identify miRNAs that may underlie AADs, we used two complementary approaches that leveraged the genotypic and phenotypic diversity of the Collaborative Cross (CC) mouse population. In the first approach, we sought to identify miRNA expression quantitative trait loci (eQTL) that overlap QTL for AAD-related phenotypes...
2015: BMC Genomics
https://www.readbyqxmd.com/read/25944053/microrna-155-modulates-p2r-signaling-and-th2-priming-of-dendritic-cells-during-allergic-airway-inflammation-in-mice
#12
A Zech, C K Ayata, F Pankratz, A Meyer, K Baudiß, S Cicko, G G Yegutkin, S Grundmann, M Idzko
BACKGROUND: Dendritic cells (DCs) are the professional antigen-presenting cells (APCs) in the lung. They are known to be key players in the induction and maintenance of allergic asthma by cross-linking innate and adaptive immune responses. MicroRNAs (miRNAs) are known to influence cell fate and function by translational suppression or induction of messenger RNA (mRNA) degradation. miR-155 has been shown to be a crucial regulator of the immune system. However, its function in the pathogenesis of allergic airway inflammation (AAI) is not completely elucidated yet...
September 2015: Allergy
https://www.readbyqxmd.com/read/25615015/genomewide-analysis-of-small-rnas-in-nonembryogenic-and-embryogenic-tissues-of-citrus-microrna-and-sirna-mediated-transcript-cleavage-involved-in-somatic-embryogenesis
#13
Xiao-Meng Wu, Shu-Jun Kou, Yuan-Long Liu, Yan-Ni Fang, Qiang Xu, Wen-Wu Guo
Somatic embryogenesis (SE) is a process of somatic cells becoming dedifferentiated and generating embryos. SE has been widely used in biotechnology as a powerful way of regeneration and a model system for studying plant embryogenesis, but the controlling mechanisms of SE are far from clear. Here, we show the genomewide profiles of miRNAs/siRNAs and their target genes in nonembryogenic and embryogenic tissues of 'Valencia' sweet orange. By high-throughput sequencing (HTS) of small RNAs and RNA degradome tags, we identified 50 known and 45 novel miRNAs, 130 miniature inverted-repeat transposable elements (MITEs) derived, 94 other and 235 phased small interfering RNAs (siRNAs), as well as 203 target genes...
April 2015: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/25515563/identification-of-wolbachia-responsive-micrornas-in-the-two-spotted-spider-mite-tetranychus-urticae
#14
Xia Rong, Yan-Kai Zhang, Kai-Jun Zhang, Xiao-Yue Hong
BACKGROUND: The two-spotted spider mite, Tetranychus urticae, is infected with Wolbachia, which have the ability to manipulate host reproduction and fitness. MicroRNAs (miRNAs) are small non-coding RNAs that are involved in many biological processes such as development, reproduction and host-pathogen interactions. Although miRNA was observed to involve in Wolbachia-host interactions in the other insect systems, its roles have not been fully deciphered in the two-spotted spider mite. RESULTS: Small RNA libraries of infected and uninfected T...
December 16, 2014: BMC Genomics
https://www.readbyqxmd.com/read/25443390/diversity-expression-and-mrna-targeting-abilities-of-argonaute-targeting-mirnas-among-selected-vascular-plants
#15
Soham Jagtap, Padubidri V Shivaprasad
BACKGROUND: Micro (mi)RNAs are important regulators of plant development. Across plant lineages, Dicer-like 1 (DCL1) proteins process long ds-like structures to produce micro (mi) RNA duplexes in a stepwise manner. These miRNAs are incorporated into Argonaute (AGO) proteins and influence expression of RNAs that have sequence complementarity with miRNAs. Expression levels of AGOs are greatly regulated by plants in order to minimize unwarranted perturbations using miRNAs to target mRNAs coding for AGOs...
2014: BMC Genomics
https://www.readbyqxmd.com/read/25024218/transcriptomics-identified-a-critical-role-for-th2-cell-intrinsic-mir-155-in-mediating-allergy-and-antihelminth-immunity
#16
Isobel S Okoye, Stephanie Czieso, Eleni Ktistaki, Kathleen Roderick, Stephanie M Coomes, Victoria S Pelly, Yashaswini Kannan, Jimena Perez-Lloret, Jimmy L Zhao, David Baltimore, Jean Langhorne, Mark S Wilson
Allergic diseases, orchestrated by hyperactive CD4(+) Th2 cells, are some of the most common global chronic diseases. Therapeutic intervention relies upon broad-scale corticosteroids with indiscriminate impact. To identify targets in pathogenic Th2 cells, we took a comprehensive approach to identify the microRNA (miRNA) and mRNA transcriptome of highly purified cytokine-expressing Th1, Th2, Th9, Th17, and Treg cells both generated in vitro and isolated ex vivo from allergy, infection, and autoimmune disease models...
July 29, 2014: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/24610935/absence-of-c-jun-nh2-terminal-kinase-1-protects-against-house-dust-mite-induced-pulmonary-remodeling-but-not-airway-hyperresponsiveness-and-inflammation
#17
COMPARATIVE STUDY
Jos L J van der Velden, Sidra M Hoffman, John F Alcorn, Jane E Tully, David G Chapman, Karolyn G Lahue, Amy S Guala, Lennart K A Lundblad, Minara Aliyeva, Nirav Daphtary, Charles G Irvin, Yvonne M W Janssen-Heininger
Chronic allergic asthma leads to airway remodeling and subepithelial fibrosis via mechanisms not fully understood. Airway remodeling is amplified by profibrotic mediators, such as transforming growth factor-β1 (TGF-β1), which plays a cardinal role in various models of fibrosis. We recently have identified a critical role for c-Jun-NH2-terminal-kinase (JNK) 1 in augmenting the profibrotic effects of TGF-β1, linked to epithelial-to-mesenchymal transition of airway epithelial cells. To examine the role of JNK1 in house dust mite (HDM)-induced airway remodeling, we induced allergic airway inflammation in wild-type (WT) and JNK1-/- mice by intranasal administration of HDM extract...
May 1, 2014: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/24330037/an-analysis-of-the-small-rna-transcriptome-of-four-developmental-stages-of-the-citrus-red-mite-panonychus-citri
#18
B Liu, W Dou, T-B Ding, R Zhong, C-Y Liao, W-K Xia, J-J Wang
The citrus red mite (Panonychus citri) can feed on more than 112 plant species around the world. Endogenous small RNAs (sRNAs) have proved to be important components of gene regulation in many eukaryotes. Recently, many sRNAs have been shown to be involved in various biological processes, such as development in many animals, including insects; however, to date, no sRNAs have been reported in the citrus red mite. Using Illumina sequencing, several categories of sRNAs were identified, including 594 known microRNAs (miRNAs) grouped into 206 families and 31 novel miRNAs in the four developmental stages of citrus red mite...
April 2014: Insect Molecular Biology
https://www.readbyqxmd.com/read/24043765/vegf-controls-lung-th2-inflammation-via-the-mir-1-mpl-myeloproliferative-leukemia-virus-oncogene-p-selectin-axis
#19
Seyedtaghi Takyar, Hema Vasavada, Jian-ge Zhang, Farida Ahangari, Naiqian Niu, Qing Liu, Chun Geun Lee, Lauren Cohn, Jack A Elias
Asthma, the prototypic Th2-mediated inflammatory disorder of the lung, is an emergent disease worldwide. Vascular endothelial growth factor (VEGF) is a critical regulator of pulmonary Th2 inflammation, but the underlying mechanism and the roles of microRNAs (miRNAs) in this process have not been defined. Here we show that lung-specific overexpression of VEGF decreases miR-1 expression in the lung, most prominently in the endothelium, and a similar down-regulation occurs in lung endothelium in Th2 inflammation models...
September 23, 2013: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/23837216/influence-of-aeroallergens-on-the-incidence-of-conjunctivitis-in-zagreb-and-zagreb-county
#20
Renata Peternel, Ivan Toth, Predrag Hercog, Bozo Vojniković, Rasa Cop, Mirna Bradić-Hammoud
The aim of this study was to determine the temporal and spatial variations of pollen spectra in the City of Zagreb and Zagreb County according to frequency of inhalation allergy and rhino-conjunctivitis in the adult population by setting allergen/patient relationship. The study was carried out at three inland sites in Croatia during four years (2003-2006). A number of 2,192 patients have been tested for allergy skin prick tests over the same period. The majority of patients allergic to pollen allergens were sensitized to allergens from the plant pollen which belong to the botanical family of grass 46...
April 2013: Collegium Antropologicum
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