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Depression pregnancy

Sophie Khadr, Venetia Clarke, Kaye Wellings, Laia Villalta, Andrea Goddard, Jan Welch, Susan Bewley, Tami Kramer, Russell Viner
BACKGROUND: Young people are disproportionately affected by sexual assault, yet longitudinal data are sparse. This paper examines the characteristics of adolescents presenting to sexual assault services and mental and sexual health outcomes after an assault. METHODS: This was a prospective cohort study in adolescents aged 13-17 years attending the Sexual Assault Referral Centres serving Greater London, UK, over 2 years. Baseline interviews (T0) were done less than 6 weeks after an assault to collect data on sociodemographic and assault characteristics and psychological symptoms, with follow-up interviews (T1) at 4-5 months after the assault...
September 2018: Lancet Child & Adolescent Health
Elizabeth J Mayer-Davis, David M Maahs, Michael Seid, Jamie Crandell, Franziska K Bishop, Kimberly A Driscoll, Christine M Hunter, Jessica C Kichler, Debra Standiford, Joan M Thomas
BACKGROUND: Adolescents with type 1 diabetes commonly have poor glycaemic control. We aimed to test the efficacy of a newly developed adaptive behavioral intervention (Flexible Lifestyles Empowering Change; FLEX) on metabolic and psychosocial outcomes in adolescents with type 1 diabetes. METHODS: Young people (13-16 years, type 1 diabetes duration >1 year, HbA1c of 64-119 mmol/mol [8·0-13·0%], and without other serious medical conditions or pregnancy) from two clinical sites (Colorado and Ohio, USA) were eligible for enrolment...
September 2018: Lancet Child & Adolescent Health
Vanessa R Kay, Matthew T Ratsep, Lindsay S Cahill, Andrew F Hickman, Bruno Zavan, Margaret E Newport, Jacob Ellegood, Christine L Laliberte, James N Reynolds, Peter Carmeliet, Chandrakant Tayade, John G Sled, B Anne Croy
Preeclampsia, a hypertensive syndrome occurring in 3-5% of human pregnancies, has lifelong health consequences for the fetus. Cognitive ability throughout life is altered and adult stroke risk is increased in these offspring. One potential etiological factor for altered brain development is low concentrations of pro-angiogenic placental growth factor (PGF). Impaired PGF production may promote an anti-angiogenic fetal environment during neural and cerebrovascular development. We previously reported delayed vascularization of the hindbrain, altered retinal vascular organization and less connectivity in the circle of Willis in Pgf-/- mice...
August 17, 2018: Physiological Genomics
Hiroaki Tanaka, Shinji Katsuragi, Junichi Hasegawa, Kazuhiro Osato, Masahiko Nakata, Takeshi Murakoshi, Akihiko Sekizawa, Naohiro Kanayama, Isamu Ishiwata, Tomoaki Ikeda
AIM: To investigate the influence of reproductive medicine in maternal death cases in Japan. METHODS: This retrospective study investigated the incidence of maternal deaths related to reproductive medicine in Japan from 2013 to 2015, and the relationship between fertility treatment and maternal death. RESULTS: Fifteen out of 134 women (11.2%) involved in this study who underwent treatment for infertility died. Four experienced pregnancy with severe maternal complications (26...
August 16, 2018: Journal of Obstetrics and Gynaecology Research
Anna Dencker, Christina Nilsson, Cecily Begley, Elisabeth Jangsten, Margareta Mollberg, Harshida Patel, Helena Wigert, Eva Hessman, Helen Sjöblom, Carina Sparud-Lundin
PROBLEM: Fear of childbirth negatively affects women during pregnancy and after birth. AIM: To summarise the findings of published studies regarding possible causes/predisposing factors and outcomes of fear of childbirth for childbearing women. DESIGN: A systematic review, searching five databases in March 2015 for studies on causes/predisposing factors and outcomes of fear of childbirth, as measured during pregnancy and postpartum. Quality of included studies was assessed independently by pairs of authors...
August 13, 2018: Women and Birth: Journal of the Australian College of Midwives
Arianna Di Florio, Katherine Gordon-Smith, Liz Forty, Michael R Kosorok, Christine Fraser, Amy Perry, Andrew Bethell, Nick Craddock, Lisa Jones, Ian Jones
BACKGROUND: Pregnancy and childbirth are a period of high risk for women with bipolar disorder and involve difficult decisions particularly about continuing or stopping medications.AimsTo explore what clinical predictors may help to individualise the risk of perinatal recurrence in women with bipolar disorder. METHOD: Information was gathered retrospectively by semi-structured interview, questionnaires and case-note review from 887 women with bipolar disorder who have had children...
September 2018: British Journal of Psychiatry: the Journal of Mental Science
Hege Verpe, Marian Kjellevold, Vibeke Moe, Lars Smith, Unni T Vannebo, Kjell Morten Stormark, Margaret Ljosnes Søvik, Siv Skotheim
BACKGROUND: In most maternity wards in Norway, early discharge (<48 hour) is the norm. To monitor newborns' and women's health during the first week after delivery, most maternity wards offer early check-ups, where families return to the hospital (standard care). However, a few municipalities offer home visits by midwives (domiciliary care) to ensure seamless services for the family. AIM: The primary aim of this study was to explore whether different follow-up strategies were differently associated with maternal depression and breastfeeding habits, 6 weeks and 6 months postpartum...
August 15, 2018: Scandinavian Journal of Caring Sciences
Wondale Getinet, Tadele Amare, Berhanu Boru, Shegaye Shumet, Wubet Worku, Telake Azale
Introduction: Antenatal depression is a syndrome, in which women experience depressed mood, excessive anxiety, insomnia, and change in weight during the period of pregnancy. Maternal depression negatively influences child outcomes and maternal health. Antenatal depression was measured by different rating scales, namely, BDI, EPDS, and PHQ. The objective of this systematic review was to synthesize logical evidence about the prevalence and potential risk factors of antenatal depression in Ethiopia...
2018: Depression Research and Treatment
S K Bhat, L J Beilin, M Robinson, S Burrows, T A Mori
There is an increasing incidence of overweight/obesity and mental health disorders in young adults and the two conditions often coexist. We aimed to investigate the influence of antenatal and postnatal factors that may underlie this association with a focus on maternal prenatal smoking, socio-economic status and gender. Data from the Western Australian Pregnancy Cohort (Raine) Study (women enrolled 1989-1991) including 1056 offspring aged 20 years (cohort recalled 2010-2012) were analyzed (2015-2016) using multivariable models for associations between offspring depression scores (DASS-21 Depression-scale) and body mass index (BMI), adjusting for pregnancy and early life factors and offspring behaviours...
August 16, 2018: Journal of Developmental Origins of Health and Disease
Amritha Bhat, Theresa Hoeft, Erin McCoy, Jurgen Unutzer, Susan D Reed
INTRODUCTION: Symptoms of depression during pregnancy and the postpartum period can negatively impact parenting. It is important to understand the parenting experiences of women with depression, and what parenting support they need. METHODS: This is a mixed methods analysis of data (demographic data, depression outcomes, patient survey results, and transcripts of patient and care manager focus groups) from an open treatment trial of the feasibility of delivering perinatal depression treatment using collaborative care in a rural obstetric setting...
August 15, 2018: Journal of Psychosomatic Obstetrics and Gynaecology
Anna Katharina Kurzeck, Beatrice Kirsch, Elif Weidinger, Frank Padberg, Ulrich Palm
Major depression is the most frequent morbidity in pregnancy. The first-line therapies, psychopharmacologic treatment and psychotherapy, are either insufficient or may cause severe or teratogenic adverse events. As a result of its local limitation to the patient's brain, transcranial direct current stimulation (tDCS) could potentially be an ideal treatment for pregnant women with depression. A literature search was conducted in medical databases, globally published newspapers, search engines, and clinical trial registers to collect all articles on tDCS for the treatment of depression during pregnancy...
August 14, 2018: Brain Sciences
C W C Cheung, S Saravelos, T Y A Chan, D S Sahota, C C Wang, P W Chung, T C Li
OBJECTIVE: To ascertain whether stress biomarker and psychological indices of stress may predict both conception and miscarriage rates in women undergoing in-vitro fertilization/ intracytoplasmic sperm injection (IVF/ ICSI). DESIGN: Prospective observational study. SETTING: A university-affiliated tertiary hospital. POPULATION OR SAMPLE: Infertility women who were undergoing fresh or frozen IVF/ICSI cycles. METHODS: Subjects were recruited to (1) completed validated psychological questionnaires (visual analogue scale of stress, state trait anxiety inventory, perceived stress scale, fertility problem Inventory, Beck depression inventory, and general health questionnaire), at the time of embryo transfer (ET) and pregnancy testing (PT), and (2) provided saliva samples for alpha amylase (sAA) measurement before and after ET and at PT...
August 14, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Gideon Koren, Asher Ornoy
Depression occurs during pregnancy in 3.9-12.8% of the women. The different serotonin reuptake inhibitors (SRIs) are metabolized in the liver by CYP450 enzymes. CYP2D6 metabolizes paroxetine, fluoxetine, duloxetine and venlafaxine, while CYP2C19 deactivates citalopram and escitalopram. Polymorphisms in these enzymes change the metabolic clearance and levels of these drugs. Higher metabolism of most SRIs in late pregnancy results in lower maternal levels, which could result in decreased efficacy. Very few studies have addressed the potential interaction between pregnancy-induced increase in 2D6 metabolism and specific genotypes of the women, suggesting that ultra-rapid and extensive metabolizers exhibit lower serum concentrations than the other slower genotypes...
August 14, 2018: Pharmacogenomics
Ruth Martis, Caroline A Crowther, Emily Shepherd, Jane Alsweiler, Michelle R Downie, Julie Brown
BACKGROUND: Successful treatments for gestational diabetes mellitus (GDM) have the potential to improve health outcomes for women with GDM and their babies. OBJECTIVES: To provide a comprehensive synthesis of evidence from Cochrane systematic reviews of the benefits and harms associated with interventions for treating GDM on women and their babies. METHODS: We searched the Cochrane Database of Systematic Reviews (5 January 2018) for reviews of treatment/management for women with GDM...
August 14, 2018: Cochrane Database of Systematic Reviews
Kimberly Stanford, Alyssa Cappetta, Roy Ahn, Wendy Macias-Konstantopoulos
Trafficking of adults and children for both sex and labor is a human rights violation occurring with alarming frequency throughout the world, and resulting in profound harm to close-knit communities and severe health consequences for victims. Certain areas, such as the country of Paraguay, are at a higher risk for trafficking due to unique economic, cultural, and geographic factors. Thousands of people, especially children, are trafficked within Paraguay's borders, and many eventually are transported to neighboring countries and sometimes to Europe and elsewhere...
August 11, 2018: Journal of Interpersonal Violence
Joëlle Darwiche, Anne Milek, Jean-Philippe Antonietti, Yvan Vial
BACKGROUND: Pregnancy after infertility is a challenging experience. The first-trimester screening test may add stress. Partner support reduces psychological distress in pregnant women after spontaneous conception. No data are available for women who conceive via assisted reproductive technology. AIM: To assess whether there was a difference between couples who underwent assisted reproductive technology and couples who conceived spontaneously in the support they felt they provided to their partner and whether their perception of support received from their partner reduced their distress...
August 9, 2018: Women and Birth: Journal of the Australian College of Midwives
Catriona Hippman, Lynda G Balneaves
BACKGROUND: Depression is common, particularly among women of childbearing age, and can have far-reaching negative consequences if untreated. Efficacious treatments are available, but little is known about how women make depression treatment decisions during pregnancy. The purpose of this narrative review is to interpretively synthesize literature on women's decision making (DM) regarding antidepressant use during pregnancy. METHODS: The databases PubMed, CINAHL, and PsycINFO were searched between May 2015 and August 2017 for peer-reviewed, English-language papers using terms such as "depression," "pregnancy," and "DM...
August 12, 2018: Depression and Anxiety
Elizabeth M Camacho, Gemma E Shields
OBJECTIVES: Anxiety and/or depression during pregnancy or year after childbirth is the most common complication of childbearing. Economic evaluations of interventions for the prevention or treatment of perinatal anxiety and/or depression (PAD) were systematically reviewed with the aim of guiding researchers and commissioners of perinatal mental health services towards potentially cost-effective strategies. METHODS: Electronic searches were conducted on the MEDLINE, PsycINFO and NHS Economic Evaluation and Health Technology Assessment databases in September 2017 to identify relevant economic evaluations published since January 2000...
August 10, 2018: BMJ Open
Adele Krusche, Maret Dymond, Susannah E Murphy, Catherine Crane
OBJECTIVE: Prenatal depression, stress and anxiety are significant predictors of postnatal depression and also have a direct negative impact on the family. Helpful psychological interventions during pregnancy are scarce and expensive, and usually only available for a small percentage of those suffering or deemed to be at risk. The aim of this study was to evaluate the potential of an online mindfulness course for expectant mothers. DESIGN: A randomised study was conducted to explore differences between control and active participants allocated to take an online mindfulness course, offered free to research participants, or wait...
July 29, 2018: Midwifery
Kari Grethe Hjorthaug Gallaher, Anastasiya Slyepchenko, Benicio N Frey, Kristin Urstad, Signe K Dørheim
Women often experience sleep disturbances and worsening sleep quality throughout pregnancy and postpartum. Circadian rhythms are closely linked to sleep problems and mood disorders. This systematic review provides a summary of studies of circadian rhythms and associated sleep problems and maternal distress, among postpartum women. Articles were idenitfied through a systematic literature search. Circadian rhythm disturbances were strongly correlated with depression, social factors and mothers`s exposure to light postpartum...
September 2018: Sleep Medicine Clinics
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