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Amanda E Pope, Nicholas Stanzione, Bita V Naini, Maria Garcia-Lloret, Kevin A Ghassemi, Elizabeth A Marcus, Martin G Martin, Laura J Wozniak
OBJECTIVE: Recent studies show increased serum and esophageal IgG4 in patients with eosinophilic esophagitis (EoE), suggesting a possible IgG4-involved process. The role of IgG4 in pediatric EoE has not been extensively investigated. Our aim was to analyze IgG4 in esophageal tissue in children in parallel to that in adults with EoE. METHODS: In a retrospective institutional review board-approved study, we performed immunohistochemical staining of IgG4 in esophageal biopsy specimens from 39 subjects: children with EoE (n = 16), adults with EoE (n = 15), children with reflux esophagitis (n = 4), and pediatric controls (n = 4)...
December 11, 2018: Journal of Pediatric Gastroenterology and Nutrition
Mohammad Soleimani, Reza Mirshahi, Seyed Ali Tabatabaei, Bita Momenaei, Mirataollah Salabati, Mohammad Reza Ghomi
PURPOSE: To introduce a new surgical technique for the localization of corneal bulla to drain a massive corneal hydrops. METHODS: Four consecutive cases with acute large protruded hydrops were selected. A limbal paracentesis was made via 15° blade. Afterward, trypan blue with a concentration of 0.1% was injected into the anterior chamber. Upon pooling trypan blue in the bulla, the surgeon immediately marked the primary site of stromal staining before further spreading of the dye...
December 12, 2018: European Journal of Ophthalmology
Afsoon Afshari, Ramin Yaghobi, Negar Azarpira, Bita Gerami Zadeh, Seyed Ali Malek Hosseini, Mojtaba Darbouy, Mohammad Hossein Karimi
Cytokines have prominent roles in activating of different T cells and shifting the immune response, in this study the role of three cytokines (IL-21, IL-23 and IL-27) is investigated in the liver transplant rejection. Three EDTA-treated blood samples were collected from each liver transplanted patient in 1st, 4th and 7th day of post-transplantation. The expression level of the mentioned cytokines was determined using real-time PCR for all samples. Also, the serum levels of cytokines were determined using ELISA tests...
August 12, 2018: Iranian Journal of Allergy, Asthma, and Immunology
Kristian Peters, James Bradbury, Sven Bergmann, Marco Capuccini, Marta Cascante, Pedro de Atauri, Timothy M D Ebbels, Carles Foguet, Robert Glen, Alejandra Gonzalez-Beltran, Ulrich L Günther, Evangelos Handakas, Thomas Hankemeier, Kenneth Haug, Stephanie Herman, Petr Holub, Massimiliano Izzo, Daniel Jacob, David Johnson, Fabien Jourdan, Namrata Kale, Ibrahim Karaman, Bita Khalili, Payam Emami Khonsari, Kim Kultima, Samuel Lampa, Anders Larsson, Christian Ludwig, Pablo Moreno, Steffen Neumann, Jon Ander Novella, Claire O'Donovan, Jake T M Pearce, Alina Peluso, Marco Enrico Piras, Luca Pireddu, Michelle A C Reed, Philippe Rocca-Serra, Pierrick Roger, Antonio Rosato, Rico Rueedi, Christoph Ruttkies, Noureddin Sadawi, Reza M Salek, Susanna-Assunta Sansone, Vitaly Selivanov, Ola Spjuth, Daniel Schober, Etienne A Thévenot, Mattia Tomasoni, Merlijn van Rijswijk, Michael van Vliet, Mark R Viant, Ralf J M Weber, Gianluigi Zanetti, Christoph Steinbeck
Background: Metabolomics is the comprehensive study of a multitude of small molecules to gain insight into an organism's metabolism. The research field is dynamic and expanding with applications across biomedical, biotechnological and many other applied biological domains. Its computationally-intensive nature has driven requirements for open data formats, data repositories and data analysis tools. However, the rapid progress has resulted in a mosaic of independent-and sometimes incompatible-analysis methods that are difficult to connect into a useful and complete data analysis solution...
December 7, 2018: GigaScience
Saeed Asgary, Bita Talebzadeh
When nonsurgical and surgical endodontic retreatments are impractical, intentional replantation (IR) might be employed as an accepted endodontic treatment procedure. This report describes an IR and root amputation of a tooth with several endodontic complications. A 28-year-old woman was referred for management of tooth #37. The tooth had a history of root canal therapy by a general dentist. Clinically the tooth was sensitive to palpation/percussion. Radiographic evaluation showed concurrent root/furcal perforations associated with radiolucent lesions, an inadequate root canal treatment and massive gutta-percha overextensions via perforation sites...
December 7, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
Hidetake Kawajiri, Juan B Grau, Jacqueline H Fortier, David Glineur
Bilateral internal thoracic artery (BITA) grafting is considered a superior choice for coronary artery bypass grafting (CABG). While the 10-year outcomes of BITA grafting from the recent Arterial Revascularization Trial (ART) are still pending, numerous observational studies have demonstrated the advantages of BITA grafting. These include better long-term graft patency and freedom from arteriosclerosis, in addition to higher survival rate compared to CABG using only the left internal thoracic artery (ITA). The different BITA configurations are in situ and composite-the choice of optimal grafting configuration is challenging...
September 2018: Annals of Cardiothoracic Surgery
Harold L Lazar
Bilateral internal thoracic artery (BITA) grafting may prolong survival in coronary artery bypass graft (CABG) patients, but its use has been curtailed due to concerns of deep sternal wound infections (DSWI) resulting in mediastinitis. This article examines the association of single internal thoracic artery (SITA) and BITA grafting and the role of harvesting techniques with the development of DSWI in CABG patients. The development of DSWI following BITA grafting is multifactorial and is independent of the harvesting technique...
September 2018: Annals of Cardiothoracic Surgery
Mehdi Salehipour, Bita Geramizadeh, Niloofar Dastgheib, Alireza Makarem, Ardalan Asadollah Poor, Negar Taheri
No abstract text is available yet for this article.
March 2019: Urology Case Reports
Rebecca A Sosa, Maura Rossetti, Bita V Naini, Victoria M Groysberg, Fady M Kaldas, Ronald W Busuttil, Yu-Ling Chang, David W Gjertson, Jerzy W Kupiec-Weglinski, Elaine F Reed
OBJECTIVE AND BACKGROUND: Pattern recognition receptors (PRRs) on immune and parenchymal cells can detect danger-associated molecular patterns (DAMPs) released from cells damaged during ischemia-reperfusion injury (IRI), in heart attack or stroke settings, but also as an unavoidable consequence of solid organ transplantation. Despite IRI being a significant clinical problem across all solid organ transplants, there are limited therapeutics and patient-specific diagnostics currently available...
November 22, 2018: Annals of Surgery
Pardis Mokhtary, Bita Javan, Mahrokh Sharbatkhari, Alireza Soltani, Vahid Erfani-Moghadam
Introduction: Novel and safe delivery solutions for RNAi therapeutics are essential to obtain the full potential of cancer gene therapy. Methods: In this study, cationic vesicular nanocarrier was applied for delivering lnc urothelial carcinoma-associated 1 (lnc UCA1) shRNA expression vector to MCF-7 cells. The physicochemical characteristics, cytotoxicity, and transfection efficiency of cationic vesicles prepared from various molar ratios of amphiphilic surfactant Tween 80 (T), squalene (S), cationic charge lipid didodecyldimethylammonium bromide, and polyethylenimine were investigated...
2018: International Journal of Nanomedicine
Saman Bahramzadeh, Mehdi Tabarsa, SangGuan You, Changsheng Li, Seraj Bita
Sulfated polysaccharides were isolated and purified from the water extract of Cystoseira indica using DEAE Sepharose Fast Flow column to evaluate their structure and macrophage stimulating capacity. Crude and fractionated polysaccharides, CIF1 and CIF2 , were mostly composed of neutral sugars (73.1%-78.6%) with relatively lower amounts of acidic sugars (1.3%-9.0%) and sulfate esters (6.9%-9.7%). The polymer chains of polysaccharides were mainly built of different levels of glucose (2.1%-30.8%), fucose (17.2%-24...
February 1, 2019: Carbohydrate Polymers
Bita Ghafoori, Melissa Gordon Wolf, Karen Nylund-Gibson, Erika D Felix
BACKGROUND: Although considerable research has tested evidence-based practices in clinical trials, research is needed on the use of trauma-focused treatments by victims of crime and violence in naturalistic settings. This study investigated four trauma-focused treatments, prolonged exposure therapy (PE), cognitive behavioral therapy (CBT), eclectic therapy, and person-centered therapy (PCT), and assessed treatment dropout and symptom improvement over five assessment time-points. METHODS: Descriptive comparisons and pattern mixture multigroup growth models were used to assess differences between treatments on time in treatment, rate of dropout, and improvement in posttraumatic stress (PTSD) and depression symptoms in an outpatient sample of 526 clients seeking routine clinical care...
November 5, 2018: Journal of Affective Disorders
Bita Beigi, Siamak Shahidi, Alireza Komaki, Abdolrahman Sarihi, Nasrin Hashemi-Firouzi
BACKGROUND: Learning and memory are among the most important cognitive functions of the brain. Melatonin receptor type 2 (MT2R) is located in the hippocampus and participates in learning and memory processes. In the present study, we examined the role of hippocampal MT2R activation in the acquisition, consolidation, and retrieval of learning and memory in novel object recognition (NOR) and passive avoidance (PA) tasks. METHODS: IIK7 (0.03, 0.3, and 3 μg/μl/side), as a selective MT2R agonist, or vehicle was injected bilaterally into the dentate gyrus (DG) region of the hippocampus in rats five minutes before training, immediately after training, and five minutes before the retrieval-behavioral tasks, respectively...
November 15, 2018: International Journal of Neuroscience
Bita Mousavi, Françoise Botterel, Jean-Marc Costa, Pascal Arné, Jacques Guillot, Eric Dannaoui
Mucormycoses are life-threatening fungal diseases that affect a variety of patients including those with diabetes mellitus or hematological malignancies. The responsible agents, the Mucorales, are opportunistic pathogens originating from the environment such as soil or decaying organic matter. The aim of the present study was to assess the prevalence and diversity of human-pathogenic species of Mucorales in commercially available foodstuffs in France. All food samples were purchased from January 2014 to May 2015 in France...
November 14, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Ali Zarrinpar, Claire M Faltermeier, Vatche G Agopian, Bita V Naini, Michael P Harlander-Locke, Fady M Kaldas, Douglas G Farmer, Ronald W Busuttil
BACKGROUND & AIMS: With the rising prevalence of alcoholism, obesity, and metabolic syndrome, steatohepatitis will become the leading cause of end-stage liver disease and hepatocellular carcinoma (HCC) in the United States by 2025. Patients with non-alcoholic steatohepatitis (NASH) and alcoholic liver disease (ALD) have similar clinical and histopathological presentations. Whether these similarities persist in NASH and ALD patients with HCC remains unknown. METHODS: A retrospective analysis of the clinical features of adult patients from a large transplant center who underwent liver transplantation (LT) for steatohepatitis due to non-alcoholic (NASH) and alcoholic causes (ALD) between 1/1/02 and 1/1/12 was performed...
November 14, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Bita Geramizadeh, Maryam Moughali, Atefeh Shahim-Aein, Soghra Memari, Ziba Ghetmiri, Alireza Taghavi, Kamran Bagheri Lankarani
Aim: In this study we tried to find out the accuracy of biliary tract brushing cytology in our center as the largest referral center in the south of Iran. Background: Common bile duct brushing cytology has been introduced as the method of choice for the diagnosis of pancreaticobiliary malignancies. However, there have been controversial reports about the sensitivity, specificity and overall accuracy of this method in the English literature. Methods: During the study period (2012-2016) there has been 166 cases of common bile duct brushing cytology taken during endoscopic retrograde cholangiopancreatography (ERCP)...
2018: Gastroenterology and Hepatology From Bed to Bench
Tine Gadegaard Olsen, Frederik Holm, Lauge Hjorth Mikkelsen, Peter Kristian Rasmussen, Sarah E Coupland, Bita Esmaeli, Paul T Finger, Gerardo F Graue, Hans E Grossniklaus, Santosh G Honavar, Jwu Jin Khong, Penelope A McKelvie, Kaustubh Mulay, Lene Dissing Sjö, Geeta K Vemuganti, Bradley A Thuro, Steffen Heegaard
PURPOSE: To investigate and characterize the clinical features of subtype-specific orbital lymphoma. DESIGN: Retrospective, interventional case series. METHODS: The study included 7 international eye cancer centers. Patient data were collected from January 1, 1980 through December 31, 2017. A total of 797 patients with a histologically verified orbital lymphoma were included. The primary end points were overall survival, disease-specific survival and progression-free survival...
November 9, 2018: American Journal of Ophthalmology
Vida Hashemi, Ali Masjedi, Bita Hazhir-Karzar, Asghar Tanomand, Siamak Sandoghchian Shotorbani, Mohammad Hojjat-Farsangi, Ghasem Ghalamfarsa, Gholamreza Azizi, Enayat Anvari, Behzad Baradaran, Farhad Jadidi-Niaragh
RNA helicase p68 or DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 (DDX5) is a unique member of the highly conserved protein family, which is involved in a broad spectrum of biological processes, including transcription, translation, precursor messenger RNA processing or alternative splicing, and microRNA (miRNA) processing. It has been shown that p68 is necessary for cell growth and participates in the early development and maturation of some organs. Interestingly, p68 is a transcriptional coactivator of numerous oncogenic transcription factors, including nuclear factor-κβ (NF-κβ), estrogen receptor α (ERα), β-catenin, androgen receptor, Notch transcriptional activation complex, p53 and signal transducer, and activator of transcription 3 (STAT3)...
November 11, 2018: Journal of Cellular Physiology
Massimo Bonacchi, Edvin Prifti, Marco Bugetti, Orlando Parise, Guido Sani, Daniel M Johnson, Francesco Cabrucci, Sandro Gelsomino
Background: The incidence and potential factors influencing deep sternal wound infection (DSWI) in a cohort of patients undergoing coronary artery bypass grafting (CABG) using skeletonized bilateral internal thoracic artery (BITA) was explored. Furthermore, we studied influence of DSWI on long-term survival, major adverse cardiac events (MACEs) and repeat coronary revascularization (RCR). Methods: The study cohort consisted of 1,325 consecutive patients who were divided in two groups: patients experiencing DSWI (n=33, group 1) and those who did not have sternal infection (n=1,292, group 2)...
September 2018: Journal of Thoracic Disease
Vahid Mashayekhi Goyonlo, Mahboubeh Karrabi, Bita Kiafar
BACKGROUND: Treatment of cutaneous leishmaniasis remains a challenge; new physical treatment modalities including laser systems are of interest in the treatment of localized lesions. METHOD: Fourteen patients (10 females) with 20 lesions of Old World cutaneous leishmaniasis underwent weekly treatments of 1540 nm erbium glass fractional laser (Palomar) using 10 mm spot size hand piece in four passes of 50-70 mJ/cm2 fluence and 10 ms pulse duration. RESULTS: Twelve lesions were available for assessment: six (50%) improved at 6 weeks and eleven lesions (91...
November 8, 2018: Australasian Journal of Dermatology
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