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https://www.readbyqxmd.com/read/29898593/cutaneous-squamous-cell-carcinoma-italian-guidelines-by-sidemast-adapted-to-and-updating-eado-edf-eortc-guidelines
#1
Ketty Peris, Mauro Alaibac, Giuseppe Argenziano, Alessandro Di Stefani, Maria C Fargnoli, Pasquale Frascione, Giulio Gualdi, Caterina Longo, Elvira Moscarella, Luigi Naldi, Giovanni Pellacani, Nicola Pimpinelli, Pietro Quaglino, Marzia Salgarello, Pietro Sollena, Vincenzo Valentini, Iris Zalaudek, Pier G Calzavara Pinton
No abstract text is available yet for this article.
June 11, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29883464/in-situ-t-regulatory-cells-and-th17-cytokines-in-paired-samples-of-leprosy-type-1-and-type-2-reactions
#2
Maurício Barcelos Costa, Emerith Mayra Hungria, Aline Araújo Freitas, Ana Lúcia O M Sousa, Juliano Jampietro, Fernando A Soares, Mariane M A Stefani
Leprosy is a complex chronic, infectious dermato-neurological disease that affects the skin and peripheral nerves especially during immuno-inflammatory episodes known as type 1/T1R and type 2/T2R reactions. This study investigated the in situ expression of CD25+Foxp3+ Treg cells and TGF-β1, IFN-γ, IL-17 in leprosy T1R and T2R. Tregs were evaluated in 114 skin biopsies from 74 leprosy patients: 56 T1R (28-paired reaction-free/reactional biopsies, 28 unpaired T1R), 18 T2R (12 paired reaction-free/reactional biopsies, 6 unpaired T2R)...
2018: PloS One
https://www.readbyqxmd.com/read/29882592/is-a-specific-eyelid-patch-test-series-useful-results-of-a-french-prospective-study
#3
Haudrey Assier, Florence Tetart, Martine Avenel-Audran, Annick Barbaud, Marie-Christine Ferrier-le Bouëdec, Françoise Giordano-Labadie, Brigitte Milpied, Emmanuelle Amsler, Evelyne Collet, Pascal Girardin, Angèle Soria, Julie Waton, François Truchetet, Jean-Luc Bourrain, Gwendeline Gener, Claire Bernier, Nadia Raison-Peyron
BACKGROUND: Eyelids are frequent sites of contact dermatitis. No prospective study focused on eyelid allergic contact dermatitis (EACD) has yet been published, and this topic has never been studied in French patients. OBJECTIVES: To prospectively evaluate the usefulness of an eyelid series in French patients patch tested because of EACD, and to describe these patients. METHODS: We prospectively analysed standardized data for all patients referred to our departments between September 2014 and August 2016 for patch testing for suspected EACD as the main reason...
June 8, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29795621/willingness-to-pay-for-a-cure-of-low-risk-melanoma-patients-in-germany
#4
Matthias Augustin, Christine Blome, Andrea Forschner, Ralf Gutzmer, Axel Hauschild, Lucie Heinzerling, Elisabeth Livingstone, Carmen Loquai, Dirk Schadendorf, Jochen Utikal, Tobias Wagner, Sophia Wilden, Katharina C Kähler
Malignant melanoma is potentially life-threatening but in most cases curable if detected early. Willingness to pay (WTP) is a preference-based construct that reflects burden of disease by assessment of the monetary value for a hypothetical cure from disease. Since WTP (directly as total amount of money) has not been assessed so far in patients with low risk melanoma, it was interesting to gain insights in this patient population and then, in a second step, compare it directly with the WTP of their treating dermato-oncologists...
2018: PloS One
https://www.readbyqxmd.com/read/29765962/value-of-eponyms-in-dermato-trichological-nomenclature
#5
REVIEW
Ralph M Trüeb
Traditionally, syndromes have been named after the physician who originally identified the condition. These are referred to as eponymous syndromes. Nevertheless, the term eponym is to be regarded in a broader sense, since - by definition - an eponym is a person, place, or thing after whom or which something is named. Accordingly, some eponymous syndromes do not refer to the physician who originally reported the condition, but alternatively to the indicator patient, a geographic location, or a historical, literary, or mythological context...
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29678378/desquamative-gingivitis-clinical-findings-and-diseases
#6
REVIEW
Andrea D Maderal, Paul Lee Salisbury, Joseph L Jorizzo
Desquamative gingivitis is a clinical finding with several potential etiologies. Among the most common are oral lichen planus, cicatricial pemphigoid, and pemphigus vulgaris, though various other differential diagnoses exist. The presence of desquamative gingivitis often results in poor oral hygiene, which can have downstream consequences, including periodontitis and tooth loss. Though certain mucosal findings may be suggestive of a particular diagnosis, a thorough history, physical examination, and appropriate dermato- and immunopathologic assessment is necessary for narrowing this broad differential diagnosis...
May 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29650221/lymph-node-dissection-in-patients-with-melanoma-and-sentinel-lymph-node-metastasis-an-updated-evidence-based-decision-algorithm
#7
D Moreno-Ramírez, A Boada, L Ferrándiz, E Samaniego, G Carretero, E Nagore, P Redondo, P Ortiz-Romero, J Malvehy, R Botella-Estrada
Recent publication of the results of clinical trials in which lymph node dissection was not associated with any survival benefit in patients with sentinel node metastasis makes it necessary to reconsider the treatment of patients with melanoma. This article provides an update on the available evidence on the diverse factors (routes of metastatic spread, predictors, adjuvant therapy, etc.) that must be considered when treating patients with sentinel node-positive melanoma. The authors propose a decision-making algorithm for use in this clinical setting...
June 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29648669/a-clinical-prediction-model-for-surgical-site-infections-in-dermatological-surgery
#8
Xiaomeng Liu, Nicole W J Kelleners-Smeets, Melissa Sprengers, Vishal Hira, Klara Mosterd, Patty J Nelemans
To adequately identify patients at risk for surgical site infection in dermatological surgery and effectively prescribe antibiotic prophylaxis, a prediction model may be helpful. Such a model was developed using data from 1,407 patients who underwent dermatological surgery without antibiotic prophylaxis. The multivariable logistic regression model included type of closure, tumour location and defect size as risk factors. Bootstrapping was used for internal validation. The overall performance of the model was good, with an area under the curve of 84...
July 11, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29624652/religious-stigmata-a-dermato-psychiatric-approach-and-differential-diagnosis
#9
REVIEW
Elio Kechichian, Elie Khoury, Sami Richa, Roland Tomb
BACKGROUND: Stigma refers to the wounds reproduced on the human body, similar to the ones inflicted on the Christ during his crucifixion, on the palms, soles, and head, as well as the right or the left side of the chest, the lips and, the back. Whether they are genuine or fabricated, stigmata are still considered a medical enigma. OBJECTIVE: To summarize and analyze all available medical data about stigmata, integrating both its dermatological and psychiatric features...
August 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29619437/risk-factors-of-vulvovaginal-candidiasis-in-dermato-venereology-outpatients-clinic-of-soetomo-general-hospital-surabaya-indonesia
#10
Dharin Serebrina Arfiputri, Afif Nurul Hidayati, Samsriyaningsih Handayani, Evy Ervianti
Background: Vulvovaginal Candidiasis (VVC) is one-third of vaginitis case. About 75% of women will have at least one episode of VVC. Complication of VVC can be unfavorable to impact the patient's quality of life. Knowing its risk factors can prevent someone suffering from pathological VVC and its sequelae. The purpose of this study was to identify risk factors of VVC. Materials and Methods: A descriptive retrospective study was conducted by total sampling to 213 medical records of VVC patients from 869 fluor albus patients in Sexually Transmitted Infection (STI) Division, Dermatology and Venereology Outpatient Clinic in Dr...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29565968/blood-coagulation-abnormalities-in-multibacillary-leprosy-patients
#11
Débora Santos da Silva, Lisandra Antonia Castro Teixeira, Daniela Gois Beghini, André Teixeira da Silva Ferreira, Márcia de Berredo Moreira Pinho, Patricia Sammarco Rosa, Marli Rambaldi Ribeiro, Monica Di Calafiori Freire, Mariana Andrea Hacker, José Augusto da Costa Nery, Maria Cristina Vidal Pessolani, Ana Maria Freire Tovar, Euzenir Nunes Sarno, Jonas Perales, Fernando Augusto Bozza, Danuza Esquenazi, Robson Queiroz Monteiro, Flavio Alves Lara
BACKGROUND: Leprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae infection. In 2016, more than 200,000 new cases of leprosy were detected around the world, representing the most frequent cause of infectious irreversible deformities and disabilities. PRINCIPAL FINDINGS: In the present work, we demonstrate a consistent procoagulant profile on 40 reactional and non-reactional multibacillary leprosy patients. A retrospective analysis in search of signs of coagulation abnormalities among 638 leprosy patients identified 35 leprosy patients (5...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29564874/rheumatologic-dermato-patho-logy-the-microscope-as-a-help-for-the-clinician
#12
Franco Rongioletti
No abstract text is available yet for this article.
April 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29516114/-acute-emergencies-in-oncology
#13
REVIEW
D Nashan, S Dengler
The spectrum of dermato-oncological emergencies is multifaceted. They are particularly observed in cases with malignant melanoma due to the large number of patients and prolonged survival rates that are associated with new therapies for advanced disease. Dermato-oncological patients present to the hospital with symptoms like nausea and emesis, unexpected neurological deficits, various gastrointestinal problems, and even acute abdomen, acute breathlessness, or hemoptysis. Furthermore, emergencies can be caused by hematological problems like anemia and leukopenia...
May 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29507073/topical-treatment-for-cutaneous-leishmaniasis-dermato-pharmacokinetic-lead-optimization-of-benzoxaboroles
#14
Katrien Van Bocxlaer, Eric Gaukel, Deirdre Hauser, Seong Hee Park, Sara Schock, Vanessa Yardley, Ryan Randolph, Jacob J Plattner, Tejal Merchant, Simon L Croft, Robert T Jacobs, Stephen A Wring
Cutaneous leishmaniasis (CL) is caused by several species of the protozoan parasite Leishmania , affecting an estimated 10 million people worldwide. Previously reported strategies for the development of topical CL treatments have focused primarily on drug permeation and formulation optimization as the means to increase treatment efficacy. Our approach aims to identify compounds with antileishmanial activity and properties consistent with topical administration. Of the test compounds, five benzoxaboroles showed potent activity (50% effective concentration [EC50 ] < 5 μM) against intracellular amastigotes of at least one Leishmania species and acceptable activity (20 μM < EC50 < 30 μM) against two more species...
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29451697/optimizing-case-reports-and-case-series-guidance-on-how-to-improve-quality
#15
REVIEW
I García-Doval, J Albrecht, C Flohr, J Batchelor, J R Ingram
Case reports and case series remain an important part of journals and are often first to document medical breakthroughs. This article reviews their characteristics, aims and limitations. It provides information on how to increase the validity of the bedside decision-making process that these studies report, using tools such as validated outcomes and split-body or n-of-1 trials. A section describing tools to improve writing of case reports and case series provides suggestions for detailed reporting and good evaluation of novelty, validity and relevance...
June 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29436770/a-review-of-the-role-of-estrogen-in-dermal-aging-and-facial-attractiveness-in-women
#16
REVIEW
Edwin D Lephart
Estrogens are known to have protective and favorable influences on skin health; conversely, androgens oppose the actions of estrogens. Estrogen's chemical messages are transmitted via the classical nuclear hormone estrogen receptors (ER) alpha and beta and the rapid-acting G-coupled membrane estrogen receptor. Androgens [both testosterone and 5α-dihydrotestosterone (5α-DHT)] bind the same androgen receptor. Estrogen levels peak in the mid- to late 20s in women and then decline by 50% by 50 years of age and dramatically decrease further after menopause...
June 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29428190/-dermato-urology-male-genital-lesions-urologist-should-know
#17
A Boehm, F Bruyère
This article aimed to gather male genital dermatoses that may lead to consult a urologist, except pre-neoplastic or neoplastic lesion. METHOD: This review is based on a research on Pubmed and EM-consult database, in English and in French, using the following key terms "male genital dermatoses", "male genital lesions", "balanitis", "balanoposthitis", "dermatoses des organes génitaux externes masculines", "lésions des organes génitaux externes de l'homme", "balanoposthites"...
April 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29395579/trans-cinnamic-acid-attenuates-uva-induced-photoaging-through-inhibition-of-ap-1-activation-and-induction-of-nrf2-mediated-antioxidant-genes-in-human-skin-fibroblasts
#18
You-Cheng Hseu, Mallikarjuna Korivi, Fang-Ying Lin, Mei-Ling Li, Ruei-Wan Lin, Jia-Jiuan Wu, Hsin-Ling Yang
BACKGROUND: UVA irradiation-induced skin damage/photoaging is associated with redox imbalance and collagen degradation. OBJECTIVE: Dermato-protective efficacies of trans-cinnamic acid (t-CA), a naturally occurring aromatic compound have been investigated against UVA irradiation, and elucidated underlying molecular mechanism. METHODS: Human foreskin fibroblast-derived (Hs68) cells and nude mice were treated with t-CA prior to UVA exposure, and assayed the anti-photoaging effects of t-CA...
January 27, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29384261/the-status-of-dermoscopy-in-germany-results-of-the-cross-sectional-pan-euro-dermoscopy-study
#19
Andreas Blum, Jürgen Kreusch, Wilhelm Stolz, Giuseppe Argenziano, Ana-Maria Forsea, Del Marmol V, Iris Zalaudek, H Peter Soyer, Holger A Haenssle
BACKGROUND: Survey on the current status of dermoscopy in Germany. METHODS: In the context of a pan-European internet-based study (n = 7,480) conducted by the International Dermoscopy Society, 880 German dermatologists were asked to answer questions with respect to their level of training as well as their use and perceived benefit of dermoscopy. RESULTS: Seven hundred and sixty-two (86.6 %) participants practiced dermatology in a publicly funded health care setting; 98...
February 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29273513/zerumbone-protects-human-skin-keratinocytes-against-uva-irradiated-damages-through-nrf2-induction
#20
Hsin-Ling Yang, Chin-Ling Lee, Mallikarjuna Korivi, Jiunn-Wang Liao, Peramaiyan Rajendran, Jia-Jiuan Wu, You-Cheng Hseu
Ultraviolet A (UVA) irradiation is toxic to skin as it penetrates deep into the dermis and damages cellular components through excessive reactive oxygen species (ROS) production, which accelerates photoaging and skin cancer. We evaluated the dermato-protective efficacies of zerumbone (natural sesquiterpene of Zingiber zerumbet) in UVA-irradiated human skin keratinocyte (HaCaT) cells and mouse epidermis. Zerumbone pretreatment (2-10 μM) substantially suppressed UVA (15 J/cm2 )-induced HaCaT cell death and lactate dehydrogenase release in a dose-dependent manner...
February 2018: Biochemical Pharmacology
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