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https://www.readbyqxmd.com/read/28917712/toward-classification-criteria-for-early-osteoarthritis-of-the-knee
#1
F P Luyten, S Bierma-Zeinstra, F Dell'Accio, V B Kraus, K Nakata, I Sekiya, N K Arden, L S Lohmander
OBJECTIVE: To propose draft classification criteria for early stage osteoarthritis (OA) of the knee for use in a primary care setting. METHODS: A group of basic scientists, physician-scientists, rheumatologists, orthopedic surgeons, and physiotherapists in a workshop setting discussed potential classification criteria for early osteoarthritis of the knee. The workshop was divided into sessions around relevant topics with short state of the art presentations followed by breakout sessions, consensus discussions, and consolidation into a consensus document...
August 9, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28917373/efficacy-of-topical-rose-rosa-damascena-mill-oil-for-migraine-headache-a-randomized-double-blinded-placebo-controlled-cross-over-trial
#2
Maria Niazi, Mohammad Hashem Hashempur, Mohsen Taghizadeh, Mojtaba Heydari, Abdolhamid Shariat
AIM: To evaluate the effect of topical formulation of Rosa damascena Mill. (R. damascena) oil on migraine headache, applying syndrome diffrentiation model. METHODS AND MATERIALS: Forty patients with migraine headache were randomly assigned to 2 groups of this double-blind, placebo-controlled cross-over trial. The patients were treated for the first 2 consecutive migraine headache attacks by topical R. damascena oil or placebo. Then, after one week of washout period, cross-over was done...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28916957/perspectives-of-women-considering-bilateral-prophylactic-mastectomy-and-their-peers-towards-a-telephone-based-peer-support-intervention
#3
D St-Pierre, K Bouchard, L Gauthier, J Chiquette, Michel Dorval
Prophylactic mastectomy is an effective strategy to reduce the risk of breast cancer for women carrying a BRCA1/2 germline mutation. This decision is complex and may raise various concerns. Women considering this surgery have reported their desire to discuss the implications of this procedure with women who have undergone prophylactic mastectomy. We conducted a qualitative study to describe the topics covered during a telephone-based peer support intervention between women considering prophylactic mastectomy (recipients) and women who had undergone this surgery (peers), and to explore their perspectives regarding the intervention...
September 15, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28914592/effect-of-topically-applied-hyaluronic-acid-on-pain-and-palatal-epithelial-wound-healing-an-examiner-blind-randomized-controlled-clinical-trial
#4
Selin Yıldırım, Hafize Öztürk Özener, Başak Doğan, Bahar Kuru
BACKGROUND: This study aimed to evaluate the effects of two different concentrations of topical hyaluronic-acid on post-operative patient discomfort and wound healing of palatal donor sites following free gingival graft (FGG) surgery. METHODS: Thirty-six patients requiring FGG were randomly assigned into three groups in an examiner-blind, randomized-controlled clinical trial. After harvesting palatal grafts, 0.2% and 0.8% hyaluronic-acid gels were used in the test-1 and -2 groups, respectively...
September 15, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28904006/the-crash-report-emergency-management-dilemmas-facing-acute-physicians-in-patients-with-pulmonary-arterial-hypertension
#5
Laura C Price, Konstantinos Dimopoulos, Philip Marino, Rafael Alonso-Gonzalez, Colm McCabe, Aleksander Kemnpy, Lorna Swan, Maria Boutsikou, Ahmed Al Zahrani, Gerry J Coghlan, Benjamin E Schreiber, Luke S Howard, Rachel Davies, Mark Toshner, Joanna Pepke-Zaba, Alistair C Church, Andrew Peacock, Paul A Corris, James L Lordan, Sean Gaine, Robin Condliffe, David G Kiely, Stephen John Wort
Treatment of acute emergencies in patients with pulmonary arterial hypertension (PAH) can be challenging. In the UK and Ireland, management of adult patients with PAH is centred in eight nationally designated pulmonary hypertension (PH) centres. However, many patients live far from these centres and physicians in local hospitals are often required to manage PAH emergencies. A committee of physicians from nationally designated PH centres identified the 'most common' emergency clinical scenarios encountered in patients with PAH...
September 12, 2017: Thorax
https://www.readbyqxmd.com/read/28903827/pharmacokinetics-of-a-transdermal-fentanyl-solution-in-suffolk-sheep-ovis-aries
#6
Kimberly Y Jen, Melissa C Dyson, Patrick A Lester, Jean A Nemzek
Sheep used as surgical models require appropriate pain management, and the commonly used transdermal fentanyl patches require a long predosing period to achieve adequate plasma concentrations. The aim of this study was to assess the pharmacokinetic parameters of an FDA-approved transdermal fentanyl solution (TFS) that has yet to be tested in sheep. In this study, we compared TFS at 2.7 mg/kg (n = 2), 1.7 mg/kg (n = 3), and 0.5 mg/kg (n = 3) with the control fentanyl patch at 2 μg/kg/h (n = 1); both products were applied topically to the intrascapular region...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28902951/brachioradial-pruritus-and-notalgia-paraesthetica-a-comparative-observational-study-of-clinical-presentation-and-morphological-pathologies
#7
Manuel P Pereira, Hannah Lüling, Anette Dieckhöfer, Sabine Steinke, Claudia Zeidler, Sonja Ständer
Brachioradial pruritus (BRP) and notalgia paraesthetica (NP) represent 2 of the most common neuropathic itch syndromes. A total of 58 consecutive patients presenting at the Center for Chronic Pruritus, University Hospital Münster, were analysed with regard to clinical presentation, anatomical and morphological pathologies, impairment in quality of life, and response to treatment with topical capsaicin. Patients with BRP reported stinging and burning more often than those with NP. In the BRP group structural magnetic resonance imaging abnormalities more frequently correlated with localization of the symptoms compared with in patients with NP...
September 13, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28900607/de-novo-intraocular-amyloid-deposition-after-hepatic-transplantation-in-familial-amyloidotic-polyneuropathy
#8
Ivo Filipe Gama, Leonor Duarte Almeida
The familiar amyloid polyneuropathy (FAP) is a rare autosomal-dominant systemic amyloidosis. Amyloid deposition occurs more frequently and extensively in the vitq. The increase in intraocular pressure (IOP) is a result of deposition of transthyretin (TTR) in trabecular meshwork. Rarely, the amyloid deposition in anterior segment can be more exuberant than in posterior segment. A 42 years old man, with FAP (Val30Met mutation), liver transplantation in 1997. He was asymptomatic, without any significant ocular abnormality until 2011...
August 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28893094/retrograde-magnetic-internal-lengthening-nail-for-acute-femoral-deformity-correction-and-limb-lengthening
#9
Austin T Fragomen, S Robert Rozbruch
The Precice magnetic internal lengthening intramedullary nail is being used with great success in femur lengthening and deformity correction with a retrograde approach. Our personal history of limb lengthening and the Precice nail will be reviewed. Several technical aspects are discussed including design updates, pre operative planning, selection of nail length, the use of blocking screws and intra operative temporary external fixation, osteotomy practice, post operative management, and cost analysis. The phenomenal bone healing ability for the retrograde Precice nail after femoral osteotomy for lengthening, even after acute deformity correction, is recognized throughout the growing body of scientific publications on this topic...
September 12, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28892928/anti-inflammatory-and-analgesic-activities-of-topical-formulations-of-pterocarpus-santalinus-powder-in-rat-model-of-chronic-inflammation
#10
Priti Pravin Dhande, Amit O Gupta, Sourav Jain, Jayshree Shriram Dawane
INTRODUCTION: The incidence of arthritis is quite high and there is a need for the search of natural products to halt the progression of disease or provide symptomatic relief without significant adverse effects. AIM: This study aimed at evaluating the anti-inflammatory and analgesic activities of topical Pterocarpus santalinus in an animal model of chronic inflammation. MATERIALS AND METHODS: Albino rats of either sex were divided into five groups of six rats each (Group I - Control, Group II -Gel base, Group III -P...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892834/model-for-vocabulary-selection-of-sensitive-topics-an-example-from-pain-related-vocabulary
#11
Ensa Johnson, Juan Bornman, Kerstin Tönsing
No abstract text is available yet for this article.
September 2017: Seminars in Speech and Language
https://www.readbyqxmd.com/read/28886209/treatment-of-superficial-basal-cell-carcinoma-by-topical-photodynamic-therapy-with-fractionated-5-aminolevulinic-acid-20-versus-two-stage-topical-methylaminolevulinic-acid-results-of-a-randomized-controlled-trial
#12
J P H M Kessels, H Kreukels, P J Nelemans, M H Roozeboom, H van Pelt, K Mosterd, E R M de Haas, N W J Kelleners-Smeets
BACKGROUND: Basal cell carcinoma (BCC) is the most common type of skin cancer with growing incidence rates. Photodynamic therapy (PDT) is a frequently used treatment, especially for superficial BCC (sBCC). Two topical photosensitizing agents are currently used to treat sBCC: 5-aminolevulinic acid (ALA) and its methyl-ester (MAL). Previous research showed a high efficacy of ALA-PDT using a 2-fold fractionated illumination scheme in which two light fractions of 20 and 80 J/cm2 are delivered, four and six hours after ALA application...
September 8, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28885410/distressing-sexual-function-at-midlife-unmet-needs-practical-diagnoses-and-available-treatments
#13
James A Simon, Vanessa A Lukas
Female sexual dysfunction (FSD) is characterized as chronic sexual symptoms that manifest with personal distress in the domains of desire, arousal, orgasm, and pain. Extensive epidemiologic evidence estimates that almost 50% of perimenopausal and postmenopausal women experience FSD. Screening for FSD is not readily conducted and patient-physician discussion of sexuality is limited by the lack of physician training on the topic and by the patient-held belief that sexual issues are not medical in nature. The purpose of this commentary is to provide clinicians with a framework to approach the discussion of FSD, to clinically identify FSD through patient symptoms and physical signs, and to manage FSD in perimenopausal and postmenopausal patients with the available U...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28885297/spinal-surgeons-opinions-on-pre-and-postoperative-rehabilitation-in-patients-undergoing-lumbar-spinal-fusion-surgery-a-survey-based-study-in-the-netherlands-and-sweden
#14
Reni M A van Erp, Jetse Jelsma, Ivan P J Huijnen, Mari Lundberg, Paul C Willems, Rob J E M Smeets
STUDY DESIGN: A cross-sectional survey in the Netherlands and Sweden. OBJECTIVE: To investigate Dutch and Swedish spinal surgeons' opinions on spinal fusion pre- and postoperative rehabilitation. SUMMARY OF BACKGROUND DATA: Lumbar spinal fusion surgery is increasingly provided in patients with chronic low back pain. No guidelines however exist for pre- and postoperative rehabilitation and it is unknown what opinions spinal surgeons currently have about pre- and postoperative rehabilitation...
September 6, 2017: Spine
https://www.readbyqxmd.com/read/28882810/study-of-methods-for-assessing-research-topic-elicitation-and-prioritization-smarter-study-protocol-to-compare-qualitative-research-methods-and-advance-patient-engagement-in-research
#15
Danielle C Lavallee, Bryan Comstock, Mary R Scott, Andrew L Avins, David R Nerenz, Todd C Edwards, Donald L Patrick, Sarah O Lawrence, Zoya Bauer, Anjali R Truitt, Jeffrey G Jarvik
BACKGROUND: Involving patients as partners in research is a defining characteristic of patient-centered outcomes research (PCOR). While patients' experiential knowledge of a health condition or treatment may yield research priorities not reflected by researchers and policy makers, the methods for identifying and effectively collaborating with patients are still evolving. Patient registries and crowdsourcing may offer ease of access and convenience to both researchers and patients. Surveys and focus groups, including online modalities, have been described for prioritizing research topics...
September 7, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28882715/motor-cortex-stimulation-in-patients-suffering-from-chronic-neuropathic-pain-summary-of-an-expert-meeting-and-pre-meeting-questionnaire-combined-with-a-literature-review
#16
REVIEW
E Kurt, D J H A Henssen, M Steegers, M Staal, U Beese, J Maarrawi, B Pirotte, L Garcia-Larrea, D Rasche, J Vesper, J Holsheimer, W Duyvendak, P Herregodts, R van Dongen, M Moens
BACKGROUND: Motor Cortex Stimulation (MCS) was introduced in the early 1990's by Tsubokawa and his group for patients diagnosed with drug-resistant, central neuropathic pain. Inconsistencies concerning the details of this therapy and its outcomes and poor methodology of most clinical essays, divide the neuromodulation society worldwide in "believers" and "non-believers". A European expert meeting was organized in Brussels, Belgium by the Benelux Neuromodulation Society (BNS)in order to develop uniform MCS protocols in the pre-, intra- and post-operative course...
September 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28881348/accelerating-topical-anaesthesia-using-microneedles
#17
Lleucu B Davies, Christopher Gateley, Phillip Holland, Siôn A Coulman, James C Birchall
BACKGROUND/AIMS: Topical anaesthetics reduce pain during venous access procedures in children. However, clinical use is hindered by a significant anaesthetic onset time. Restricted diffusion of the topical anaesthetic through the stratum corneum barrier is the principal reason for the delayed onset. Microneedles can painlessly pierce the skin. This study evaluated microneedle pre-treatment of ex vivo human skin as a means to increase the rate of tetracaine permeation, in order to accelerate the onset of anaesthesia...
September 8, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28880758/the-clinical-effectiveness-of-haemoglobin-spray-as-adjunctive-therapy-in-the-treatment-of-chronic-wounds
#18
S Hunt, F Elg
OBJECTIVE: To investigate wound healing after application of adjunctive topical haemoglobin spray in patients with chronic wounds. METHOD: Consecutive patients with a diversity of chronic wounds (defined as <40% reduction in wound size within 4 weeks) were treated with standard wound care plus haemoglobin spray and evaluated over a 26-week period. Results were compared with a retrospective cohort of 50 consecutive patients treated with standard wound care alone...
September 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28879311/recent-advances-in-topical-anesthesia
#19
REVIEW
Hyo-Seol Lee
Topical anesthetics act on the peripheral nerves and reduce the sensation of pain at the site of application. In dentistry, they are used to control local pain caused by needling, placement of orthodontic bands, the vomiting reflex, oral mucositis, and rubber-dam clamp placement. Traditional topical anesthetics contain lidocaine or benzocaine as active ingredients and are used in the form of solutions, creams, gels, and sprays. Eutectic mixtures of local anesthesia cream, a mixture of various topical anesthetics, has been reported to be more potent than other anesthetics...
December 2016: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28879245/effects-of-high-dose-capsaicin-on-tmd-subjects-a-randomized-clinical-study
#20
B K Campbell, R B Fillingim, S Lee, R Brao, D D Price, J K Neubert
Temporomandibular joint disorder (TMD) is a complex musculoskeletal disorder that presents with pain, limited jaw opening, and abnormal noises in the temporomandibular joint. Despite the significant impact that TMD has in terms of suffering and financial burden, relatively few new treatments have emerged; therefore, development of novel treatments to treat TMD pain remains a high priority. The rationale of this study was to use a double-blind, vehicle-controlled clinical trial to evaluate the effects of a high-concentration (8%) capsaicin cream on TMD...
January 2017: JDR Clinical and Translational Research
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