Myung S Park, Wenjun Z Martini, Michael A Dubick, Jose Salinas, Saulius Butenas, Bijan S Kheirabadi, Anthony E Pusateri, Jeffrey A Vos, Charles H Guymon, Steven E Wolf, Kenneth G Mann, John B Holcomb
OBJECTIVES: To investigate the hemostatic status of critically ill, nonbleeding trauma patients. We hypothesized that a hypercoagulable state exists in patients early after severe injury and that the pattern of clotting and fibrinolysis are similar between burned and nonburn trauma patients. MATERIALS: Patients admitted to the surgical or burn intensive care unit within 24 hours after injury were enrolled. Blood samples were drawn on days 0 through 7. Laboratory tests included prothrombin time (PT), activated partial thromboplastin time (aPTT), levels of activated factor XI, D-dimer, protein C percent activity, antithrombin III percent activity, and thromboelastography (TEG)...
August 2009: Journal of Trauma