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Altitude And Coagulation

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https://www.readbyqxmd.com/read/29864786/genome-wide-expression-analysis-suggests-hypoxia-triggered-hyper-coagulation-leading-to-venous-thrombosis-at-high-altitude
#1
Prabhash Kumar Jha, Anita Sahu, Amit Prabhakar, Tarun Tyagi, Tathagata Chatterjee, Prathima Arvind, Jiny Nair, Neha Gupta, Babita Kumari, Velu Nair, Nitin Bajaj, Jayashree Shanker, Manish Sharma, Bhuvnesh Kumar, Mohammad Zahid Ashraf
Venous thromboembolism (VTE), a multi-factorial disease, is the third most common cardiovascular disease. Established genetic and acquired risk factors are responsible for the onset of VTE. High altitude (HA) also poses as an additional risk factor, predisposing individuals to VTE; however, its molecular mechanism remains elusive. This study aimed to identify genes/pathways associated with the pathophysiology of deep vein thrombosis (DVT) at HA. Gene expression profiling of DVT patients, who developed the disease, either at sea level or at HA-DVT locations, resulted in differential expression of 378 and 875 genes, respectively...
July 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29614518/hypobaric-hypoxia-causes-elevated-thrombin-generation-mediated-by-fviii-that-is-balanced-by-decreased-platelet-activation
#2
Cécile H Kicken, Marisa Ninivaggi, Joke Konings, Martijn Moorlag, Dana Huskens, Jasper A Remijn, Saartje Bloemen, Marcus D Lancé, Bas De Laat
INTRODUCTION:  Epidemiological studies suggest that hypobaric hypoxia at high altitude poses a risk for developing venous thromboembolism. The cause of this observed hypercoagulability remains unclear. Therefore, this study aimed to investigate the effect of hypobaric hypoxia at 3,883 m above sea level on thrombin generation and platelet activation. METHODS:  After complying with medical ethical procedures, 18 participants were recruited, of whom 1 had to leave the study prematurely due to mild acute mountain sickness...
May 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29304526/thromboelastometry-and-platelet-function-during-acclimatization-to-high-altitude
#3
Alistair S Rocke, Gordon G Paterson, Matthew T Barber, Alexander I R Jackson, Shona Main, Calum Stannett, Martin F Schnopp, J Kenneth Baillie, Elizabeth H Horne, Carl Moores, Paul Harrison, Alastair F Nimmo, A A Roger Thompson
Interaction between hypoxia and coagulation is important given the increased risk of thrombotic diseases in chronically hypoxic patients who reside at sea level and in residents at high altitude. Hypoxia alters the proteome of platelets favouring a prothrombotic phenotype, but studies of activation and consumption of specific coagulation factors in hypoxic humans have yielded conflicting results. We tested blood from 63 healthy lowland volunteers acclimatizing to high altitude (5,200 m) using thromboelastometry and assays of platelet function to examine the effects of hypoxia on haemostasis...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28802782/a-case-of-galen-vein-thrombosis-occurring-after-bilateral-acetabular-fractures-in-the-tibet-plateau-what-can-we-learn
#4
Dong-Ping Ye, Shun-Li Zhang, Quan-Hong Xu, Lin-Jie Wei
Hypoxia leads to increased red blood cells and blood viscosity at high altitude while moderate trauma increases coagulation in blood. Under the above-mentioned conditions, venous sinus thrombosis is more likely to occur. A patient suffering bilateral acetabular fractures together with the gradual disturbance of consciousness was admitted to our hospital. Though computed tomography arteriogram (CTA) of the brain displayed normal blood vessels; bilateral thalamus and brainstem infarction were found on head computed tomography (CT) and Galen vein thrombosis on cerebral computed tomography venography (CTV)...
October 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28430802/the-quality-changes-in-fresh-frozen-plasma-of-the-blood-donors-at-high-altitude
#5
Zongkui Wang, Hua Liu, Miaomiao Dou, Xi Du, Jijun Hu, Na Su, Ya Wang, Rong Zhang, Changqing Li
OBJECTIVE: According to the international guidelines, fresh frozen plasma (FFP) is unanimously used to treat coagulation disorders. The quality of FFP is critical for the clinical transfusion. Till now, few studies have integratedly evaluated the differences of FFP from blood donors at between high altitude (HA) and low altitude (LA). Besides, there were no special quality standards for HA FFP in China. MATERIALS AND METHODS: Up to 41 HA (Lhasa, 3700 m) and 46 LA (Chengdu, 500 m) blood donors were included in our study to estimate the differences of FFP from HA and LA blood donors...
2017: PloS One
https://www.readbyqxmd.com/read/27740865/plasma-proteomics-of-ladakhi-natives-reveal-functional-regulation-between-renin-angiotensin-system-and-enos-cgmp-pathway
#6
Gayatri Padhy, Anamika Gangwar, Manish Sharma, Kalpana Bhargava, Niroj Kumar Sethy
Padhy, Gayatri, Anamika Gangwar, Manish Sharma, Kalpana Bhargava, and Niroj Kumar Sethy. Plasma proteomics of Ladakhi natives reveal functional regulation between renin-angiotensin system and eNOS-cGMP pathway. High Alt Med Biol. 18:27-36, 2017.-Humans have been living in high altitudes for more than 25,000 years but the molecular pathways promoting survival and performance in these extreme environments are not well elucidated. In an attempt to understand human adaptation to high altitudes, we used two-dimensional gel electrophoresis combined with MALDI-TOF/TOF to identify plasma proteins and associated pathways of ethnic Ladakhi natives residing at 3520 m...
March 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/27485004/cerebral-vasoconstriction-reactions-and-plasma-levels-of-etbr-et-1-and-enos-in-patients-with-chronic-high-altitude-disease
#7
Shizheng Wu, Guisheng Hao, Shukun Zhang, Dongmei Jiang, Tana Wuren, Junming Luo
The aim of the present study was to examine cerebral vasoconstriction in patients with chronic high altitude disease [cerebrovascular reactivity (CVR)], and to evaluate differences in alterations of brain vascular contractile reactivity of chronic mountain sickness (CMS) patients and healthy controls. Alterations of endothelin (ET) and its receptor, as well as endothelial nitric oxide synthase (eNOS) levels in the plasma were examined to determine the cerebral reservation capacities in CMS patients. Transcranial Doppler ultrasound and carbon dioxide analysis methods were used to detect the CVR variances...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27044040/toward-understanding-the-genetic-basis-of-yak-ovary-reproduction-a-characterization-and-comparative-analyses-of-estrus-ovary-transcriptiome-in-yak-and-cattle
#8
COMPARATIVE STUDY
Daoliang Lan, Xianrong Xiong, Cai Huang, Tserang Donko Mipam, Jian Li
BACKGROUND: Yaks (Bos grunniens) are endemic species that can adapt well to thin air, cold temperatures, and high altitude. These species can survive in harsh plateau environments and are major source of animal production for local residents, being an important breed in the Qinghai-Tibet Plateau. However, compared with ordinary cattle that live in the plains, yaks generally have lower fertility. Investigating the basic physiological molecular features of yak ovary and identifying the biological events underlying the differences between the ovaries of yak and plain cattle is necessary to understand the specificity of yak reproduction...
2016: PloS One
https://www.readbyqxmd.com/read/26451374/influence-of-acute-normobaric-hypoxia-on-hemostasis-in-volunteers-with-and-without-acute-mountain-sickness
#9
Marc Schaber, Veronika Leichtfried, Dietmar Fries, Maria Wille, Hannes Gatterer, Martin Faulhaber, Philipp Würtinger, Wolfgang Schobersberger
INTRODUCTION: The aim of the present study was to investigate whether a 12-hour exposure in a normobaric hypoxic chamber would induce changes in the hemostatic system and a procoagulant state in volunteers suffering from acute mountain sickness (AMS) and healthy controls. MATERIALS AND METHODS: 37 healthy participants were passively exposed to 12.6% FiO2 (simulated altitude hypoxia of 4,500 m). AMS development was investigated by the Lake Louise Score (LLS). Prothrombin time, activated partial thromboplastin time, fibrinogen, and platelet count were measured and specific methods (i...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26439041/the-study-of-prevalence-rate-and-clinical-characteristics-of-high-altitude-deterioration
#10
S-W Xie, C Liu, Y-X Gao, Y Chen, C-H Jiang, L Chen, Y-Q Gao
OBJECTIVE: This study was aimed to investigate the prevalence rate and clinical characteristics of high altitude deterioration (HADT), which would provide a scientific basis for the diagnosis and prevention of HADT. SUBJECTS AND METHODS: A total of 175 subjects, who had migrated to a high altitude (4516 m) for more than 1 year, were investigated. A questionnaire survey based on the symptoms of HADT was conducted, and 117 subjects were determined to have HADT according to the diagnostic criteria of HADT...
September 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/24788015/high-intraocular-pressure-in-four-vitrectomized-eyes-with-intravitreal-c3f8-without-high-altitude-travel
#11
K Brosh, I Strassman, M Seelenfreund
IMPORTANCE: It is well known that altitude ascent with intravitreal gas can cause expansion of gas and intraocular pressure (IOP) elevation. According to Boyle's law, the gas bubble will not expand unless a higher altitude than the gas insertion site has been reached. We report four cases in which intravitreal gas was injected at an altitude of 790 m (Jerusalem). All four cases developed high IOP even though they did not reach a higher altitude in their post-operative period. OBSERVATIONS: A report of four patients following vitrectomy with 12% mixture of perfluoropropane and air are presented...
July 2014: Eye
https://www.readbyqxmd.com/read/24341009/-particular-features-of-erythropoiesis-in-high-altitude-and-possibilities-of-applying-of-hypoxic-hypoxia-methodology-for-the-patients-with-hemopoietic-suppression
#12
A B Makeshova, M O Éralieva, A A Levina, Iu I Mamukova, A R Raimzhanov
Conditions of hypoxic hypoxia at 3200 m height exert significant positive changes in hemopoiesis, normalizing erythropoiesis and coagulation system. Hypoxic climate therapy can be regarded as an additional efficient method to the pathogenetic treatment for patient with unpainful aplastic anemia and idiopathic thrombocytopenic purpura. It should be emphasized that patients must be out of immunosuppressive therapy when getting high altitude stationary.
July 2013: Voenno-medit︠s︡inskiĭ Zhurnal
https://www.readbyqxmd.com/read/24297866/altered-expression-of-platelet-proteins-and-calpain-activity-mediate-hypoxia-induced-prothrombotic-phenotype
#13
Tarun Tyagi, Shadab Ahmad, Neha Gupta, Anita Sahu, Yasmin Ahmad, Velu Nair, Tathagat Chatterjee, Nitin Bajaj, Shantanu Sengupta, Lilly Ganju, Shashi Bala Singh, Mohammad Z Ashraf
Oxygen-compromised environments, such as high altitude, air travel, and sports, and pathological conditions, such as solid tumors, have been suggested to be prothrombotic. Despite the indispensable role of platelets in thrombus formation, the studies linking hypoxia, platelet reactivity, and thrombus formation are limited. In the present study, platelet proteome/reactivity was analyzed to elucidate the acute hypoxia-induced prothrombotic phenotype. Rats exposed to acute simulated hypoxia (282 torr/8% oxygen) demonstrated a decreased bleeding propensity and increased platelet reactivity...
February 20, 2014: Blood
https://www.readbyqxmd.com/read/24174929/impact-of-aging-mechanism-on-model-simulated-carbonaceous-aerosols
#14
Y Huang, S Wu, M K Dubey, N H F French
Carbonaceous aerosols including organic carbon and black carbon have significant implications for both climate and air quality. In the current global climate or chemical transport models, a fixed hydrophobic-to-hydrophilic conversion lifetime for carbonaceous aerosol (τ) is generally assumed, which is usually around one day. We have implemented a new detailed aging scheme for carbonaceous aerosols in a chemical transport model (GEOS-Chem) to account for both the chemical oxidation and the physical condensation-coagulation effects, where τ is affected by local atmospheric environment including atmospheric concentrations of water vapor, ozone, hydroxyl radical and sulfuric acid...
2012: Atmospheric Chemistry and Physics
https://www.readbyqxmd.com/read/24170524/air-as-tamponade-for-retinal-detachments
#15
Aránzazu Mateo-Montoya, Marc D de Smet
PURPOSE: To determine whether air can be used as a reliable tamponade agent after pars plana vitrectomy in selected primary retinal detachment (RD). METHODS: Twelve eyes with fresh RD were included. Exclusion criteria were presence of fibrosis, fixed folds, proliferative vitreoretinopathy of grade C or greater, and giant retinal tears. The number, location, and types of breaks, extension of RD, and whether the macula was attached were documented. A 25-gauge 3-port pars plana vitrectomy was carried out...
March 2014: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/24024312/central-retinal-vein-occlusion-following-hypobaric-chamber-exposure
#16
Kyoung Min Lee, Seok Ju Yoo, Se Joon Woo
BACKGROUND: Mountain climbers who ascend to a high altitude could suffer high altitude retinopathy, which varies from tortuous retinal vessels and hemorrhages to retinal vascular obstruction. As hypobaric chamber training could imitate a fast ascent and could lead to decompression sickness, a simulated flight could also lead to a high altitude retinopathy. CASE REPORT: This paper will present a case of central retinal vein occlusion that occurred after exposure to a hypobaric chamber and Valsalva maneuver...
September 2013: Aviation, Space, and Environmental Medicine
https://www.readbyqxmd.com/read/23974848/alterations-in-coagulatory-and-fibrinolytic-systems-following-an-ultra-marathon
#17
Brian R Kupchak, Brittanie M Volk, Laura J Kunces, William J Kraemer, Martin D Hoffman, Stephen D Phinney, Jeff S Volek
PURPOSE: The aim of this study was to examine coagulatory and fibrinolytic responses to the Western States Endurance Run (WSER, June 23 to 24, 2012). The WSER is a 161-km (100 mile) trail foot race through the Sierra Nevada Mountains that involves 6,030 m of climb and 7,001 m of descent. METHODS: We examined 12 men and 4 women [mean (95 % CI), age 44.6 years (38.7-50.6)] who completed the race (24.64 h; range 16.89-29.46). Blood samples were collected the morning before the race, immediately post-race, and 1 (D1) and 2 (D2) days post-race (corresponding to 51-54 h and 75-78 h from the start of the race, respectively)...
November 2013: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/23960192/white-matter-hyperintensities-on-mri-in-high-altitude-u-2-pilots
#18
Stephen McGuire, Paul Sherman, Leonardo Profenna, Patrick Grogan, John Sladky, Anthony Brown, Andrew Robinson, Laura Rowland, Elliot Hong, Beenish Patel, David Tate, Elaine S Kawano, Peter Fox, Peter Kochunov
OBJECTIVE: To demonstrate that U-2 pilot occupational exposure to hypobaria leads to increased incidence of white matter hyperintensities (WMH) with a more uniform distribution throughout the brain irrespective of clinical neurologic decompression sickness history. METHODS: We evaluated imaging findings in 102 U-2 pilots and 91 controls matched for age, health, and education levels. Three-dimensional, T2-weighted, high-resolution (1-mm isotropic) imaging data were collected using fluid-attenuated inversion recovery sequence on a 3-tesla MRI scanner...
August 20, 2013: Neurology
https://www.readbyqxmd.com/read/23892441/cardiovascular-medicine-at-high-altitude
#19
REVIEW
Thomas F Whayne
Altitude physiology began with Paul Bert in 1878. Chronic mountain sickness (CMS) was defined by Carlos Monge in the 1940s in the Peruvian Andes as consisting of excess polycythemia. Hurtado et al performed studies in the Peruvian Andes in the 1950s to 1960s which defined acclimatization in healthy altitude natives, including polycythemia, moderate pulmonary hypertension, and low systemic blood pressure (BP). Electrocardiographic changes of right ventricular hypertrophy (RVH) were noted. Acclimatization of newcomers to altitude involves hyperventilation stimulated by hypoxia and is usually benign...
July 2014: Angiology
https://www.readbyqxmd.com/read/23549498/physical-exertion-at-high-altitude-another-risk-factor-for-coronary-stent-thrombosis
#20
Sandeep Basavarajaiah, Michael O'Sullivan
We report 2 cases of very late stent thrombosis (VLST) in patients previously treated with drug-eluting stent (DES). In both cases, VLST occurred during intense physical activities at high altitudes. Exposure to high altitudes alters the coagulation cascade, platelet morphology, and function, resulting in a hypercoagulable state. In addition, strenuous exercise provokes a procoagulant state along with increasing the risk of endothelial damage through the effects on coronary blood flow. In light of these cases, we hypothesize that individuals who are involved in intense physical activities at high altitudes may be at increased risk of stent thrombosis...
April 2013: Journal of Invasive Cardiology
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