Read by QxMD icon Read


Rory Sayres, Ankur Taly, Ehsan Rahimy, Katy Blumer, David Coz, Naama Hammel, Jonathan Krause, Arunachalam Narayanaswamy, Zahra Rastegar, Derek Wu, Shawn Xu, Scott Barb, Anthony Joseph, Michael Shumski, Jesse Smith, Arjun B Sood, Greg S Corrado, Lily Peng, Dale R Webster
OBJECTIVE: To understand the impact of deep learning diabetic retinopathy (DR) algorithms on physician readers in computer-assisted settings. DESIGN: Evaluation of diagnostic technology PARTICIPANTS: 1,796 retinal fundus images from 1,612 diabetic patients. METHODS: 10 ophthalmologists (5 general ophthalmologists, 4 retina specialists, 1 retina fellow) read images for DR severity based on the International Clinical Diabetic Retinopathy disease severity scale in one of 3 conditions: Unassisted, Grades Only, or Grades + Heatmap...
November 28, 2018: Ophthalmology
Erika Gucciardo, Sirpa Loukovaara, Petri Salven, Kaisa Lehti
Diabetic retinopathy (DR) is the most common diabetic microvascular complication and major cause of blindness in working-age adults. According to the level of microvascular degeneration and ischemic damage, DR is classified into non-proliferative DR (NPDR), and end-stage, proliferative DR (PDR). Despite advances in the disease etiology and pathogenesis, molecular understanding of end-stage PDR, characterized by ischemia- and inflammation-associated neovascularization and fibrosis, remains incomplete due to the limited availability of ideal clinical samples and experimental research models...
December 13, 2018: International Journal of Molecular Sciences
Kamal Abdolmohammadi, Fatemeh Dadgar Pakdel, Hamideh Aghaei, Sara Assadiasl, Yousef Fatahi, Negin Hosseini Rouzbahani, Alireza Rezaiemanesh, Masoud Soleimani, Lobat Tayebi, Mohammad Hossein Nicknam
Ankylosing spondylitis (AS) is an inflammatory rheumatoid disease categorized within spondyloarthropathies (SpA) and manifested by chronic spinal arthritis. Several innate and adaptive immune cells and secreted-mediators have been indicated to play a role in AS pathogenesis. Considering the limitations of current therapeutic approaches (NSAIDs, glucocorticoids, DMARDs and biologic drugs), finding new treatments with fewer side effects and high therapeutic potentials are required in AS. Mesenchymal stem cells (MSCs) with considerable immunomodulatory and regenerative properties could be able to attenuate the inflammatory responses and help tissue repair by cell-to-cell contact and secretion of soluble factors...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Veronika Rajecka, Tomas Skalicky, Stepanka Vanacova
RNA modifications are being recognized as an essential factor in gene expression regulation. They play essential roles in germ line development, differentiation and disease. In eukaryotic mRNAs, N6 -adenosine methylation (m6 A) is the most prevalent internal chemical modification identified to date. The m6 A pathway involves factors called writers, readers and erasers. m6 A thus offers an interesting concept of dynamic reversible modification with implications in fine-tuning the cellular metabolism. In mammals, FTO and ALKBH5 have been initially identified as m6 A erasers...
December 11, 2018: Biochimica et biophysica acta. Gene regulatory mechanisms
Robert B Lochhead, David Ordoñez, Sheila L Arvikar, John M Aversa, Luke S Oh, Benton Heyworth, Ruslan Sadreyev, Allen C Steere, Klemen Strle
Lyme arthritis (LA), a late disease manifestation of Borrelia burgdorferi infection, usually resolves with antibiotic therapy. However, some patients develop proliferative synovitis lasting months to several years after spirochetal killing, called post-infectious LA. In this study, we phenotyped hematopoietic and stromal cell populations in the synovial lesion ex vivo and used these findings to generate an in vitro model of LA using patient-derived fibroblast-like synoviocytes (FLS). Ex vivo analysis of synovial tissue revealed high abundance of IFNγ-producing T cells and NK cells...
December 14, 2018: Cellular Microbiology
Bianca Cioni, Ekaterina S Jordanova, Erik Hooijberg, Rianne van der Linden, Renee X de Menezes, Katherine Tan, Stefan Willems, Joris B W Elbers, Annegien Broeks, Andries M Bergman, Charlotte L Zuur, Jan Paul de Boer
BACKGROUND: Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a highly immunogenic tumor and differences in tumor microenvironment might contribute to the improved survival of HPV-positive OPSCC patient. METHODS: A comprehensive multivariate analysis with clinical and immune variables (human leukocyte antigen [HLA] I/II, programmed death ligand 1 (PD-L1), programmed death receptor 1 (PD1), T cells, and macrophages) was performed in 142 OPSCC patients...
December 14, 2018: Head & Neck
Ferdinando Carlo Sasso, Pia Clara Pafundi, Aldo Gelso, Valeria Bono, Ciro Costagliola, Raffaele Marfella, Celestino Sardu, Luca Rinaldi, Raffaele Galiero, Carlo Acierno, Chiara de Sio, Luigi Elio Adinolfi
AIMS: Diabetic retinopathy (DR) represents the main cause of blindness among adults in the industrialized Countries. Use of telemedicine could offer an easy, smart specialist fundus oculi examination, as well as putting in a screening program many patients who otherwise would be excluded. MATERIALS AND METHODS: The NO Blind is a transversal, multicentre, observational study. Its pilot phase involved nine public outpatient clinics for six months. As endpoint of the study, we assessed the prevalence of DR by retinography in a subset of the Italian population...
December 13, 2018: Diabetes/metabolism Research and Reviews
Loic Raffray, Claude Giry, David Vandroux, Stéphanie Fayeulle, Marie-Pierre Moiton, Anne Gerber, Marie-Christine Jaffar-Bandjee, Philippe Gasque
Leptospirosis is a life-threatening zoonotic disease and it has been hypothesized that the innate immune system fails to control the infection through ill-characterized mechanisms. The aim of this observational study was to better evaluate the activation processes of monocytes at the early stage of the disease. Blood samples were taken from healthy donors (n = 37) and patients hospitalized for either non-severe (n = 25) or severe (n = 32) leptospirosis. Monocyte cell counts and phenotypes were assessed by flow cytometry...
December 12, 2018: Medical Microbiology and Immunology
Zhuxi Yu, Beiyuan Zhang, Ying Xu, Yingying Hao, Jian Tang, Wenkui Yu, Qin Gu
OBJECTIVE: To analyze the clinical characteristics of bloodstream infection in patients with immune function inhibition. METHODS: A retrospective analysis was conducted. 234 patients with bloodstream infection admitted to intensive care unit (ICU) of the Affiliated Drum Tower Hospital of Nanjing University Medical School from August 1st in 2015 to December 31st in 2017 were enrolled. According to the immune function on the day of bloodstream infection, they were divided into normal immune function group [human leukocyte antigen DR (HLA-DR) > 30%, n = 144] and immunosuppression group (HLA-DR ≤ 30%, n = 90)...
November 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
J Němčanský, A Stepanov, S Němčanská, H Langrová, J Studnička
PURPOSE: To evaluate anatomical, functional and clinical efficacy of the pattern scanning laser (PASCAL®) photocoagulation in patients with diabetic retinopathy. METHODS: The cohort included 91 eyes in 50 patients (average age 63 years, 24 men and 26 women) treated at the Clinic of Ophthalmology, Faculty Hospital Ostrava, from 2008 to 2013. All eyes showed the signs of diabetic retinopathy (20.9% of eyes - very severe non-proliferative diabetic retinopathy (NPDR), 79...
2018: Ceská a Slovenská Oftalmologie
Florian Arendt, Narin Karadas
Minority group members tend to have more negative health outcomes compared to majority group members. As reducing health inequalities is a global imperative, research testing strategies to improve minority patient health outcomes are important. Evidence exists that ethnic concordance in patient-physician communication is statistically associated with positive outcomes for minority patients. Previous research has exclusively relied on non-experimental observational methods. The present study adds to this literature by presenting supplementary experimental evidence, thus increasing confidence in the causal interpretation of the relationships observed in previous studies...
December 12, 2018: Journal of Health Communication
L Cuenca, A L Gil-Martinez, L Cano-Fernandez, C Sanchez-Rodrigo, C Estrada, E Fernandez-Villalba, M T Herrero
After Alzheimer's disease, Parkinson's disease (PD) is the second most prevalent and incidental neurodegenerative disorder, affecting more than 2% of the population older than 65 years old. Since it was first described 200 years ago by Dr James Parkinson, great steps have been made in the understanding of the pathology. However, the cause(s) that initiates and perpetuates the neurodegenerative process is (are) still not clear. Thus, early diagnosis is not available, nor are there efficient therapies that can stop neurodegeneration...
December 12, 2018: Histology and Histopathology
Medhat Askar, David Sayer, Tao Wang, Michael Haagenson, Stephen R Spellman, Stephanie J Lee, Abeer Madbouly, Katharina Fleischhauer, Katharine C Hsu, Michael R Verneris, Dawn Thomas, Aiwen Zhang, Ronald M Sobecks, Navneet S Majhail
HLA haplotype mismatches have been associated with higher risk of acute graft versus host disease (aGVHD) in patients receiving HLA matched unrelated donor (URD) hematopoietic cell transplant (HCT) unrelated donors. The Gamma block (GB) is located in the central MHC region between beta and delta blocks (encoding C & B and DR & DQ antigens, respectively). GB contains many inflammatory and immune regulatory genes such as Bf, C2 and C4 genes. A single center study showed that mismatches in SNP c.2918+98G, c...
December 8, 2018: Biology of Blood and Marrow Transplantation
Teresa Rubio-Tomás, Beatriz Aguilar-Bravo, Pau Sancho-Bru
Lineage tracing of liver cells is a powerful tool to understand liver embryonic development, healthy liver cell homeostasis, tissue repair, and regeneration. Lineage tracing of biliary epithelial cells (BECs) in the adult liver has been used to assess the contribution of the biliary epithelium to liver injury, regeneration, and disease. These studies have shown the contribution of BECs to the expansion of ductular reaction (DR) and liver progenitor cells (LPCs) and eventually the generation of new hepatocytes...
2019: Methods in Molecular Biology
Odunayo O Mugisho, Colin R Green, David M Squirrell, Sarah Bould, Helen V Danesh-Meyer, Jie Zhang, Monica L Acosta, Ilva D Rupenthal
Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and retinal ganglion cell death long term. Therefore, alternative treatments that target common upstream disease mechanisms are needed. Recent studies have shown that connexin43 hemichannel blockers can reduce inflammation and prevent vessel leak in brain and spinal cord lesions...
December 8, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Laval R Enrique
The author presents a historical review about the creation of Doctor Lucio Cordova Infectious Diseases Hospital. Lucio Cordova MD, Counselor of the Charity Board in 1938, promoted a model pavilion for the hospitalization of patients with communicable diseases. An outbreak of meningococcal meningitis, between 1941 and 1942, hurried the construction of the Infectious Disease Pavilion, which was finished in 1949. The important work of the first chief of the new unit, Roque Kraljevic MD, is highlighted. In 1963, the Infectious Disease Pavilion was transformed into Dr...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Victor Vlad Costan, Camelia Tamaş, Nicolaie Dobrin, Dan Alexandru Costache, Manuela Ciocoiu
Basal cell carcinoma (BCC) is the most common type of cancer located in the periocular area. We will present the clinical case of a 63-year-old male patient who was admitted to the 2nd Clinic of Neurosurgery, "Prof. Dr. Nicolae Oblu" Emergency Clinical Hospital, Iaşi, Romania, for an ulcerated tumor of about 0.8×0.7 cm in diameter with rolled edges and central necrosis in the upper eyelid with orbital invasion. According to the patient's personal history, he also underwent Cortisone treatment for dermatomyositis...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Alexandru Daniel Jurcă, Maria Claudia Jurcă, Marius Bembea, Kinga Kozma, Magdalena Budişteanu, Cristina Gug
Congenital hyperammonemia (HA) due to inborn errors of metabolism is a rare condition with a high rate of mortality. The main effects occur at the central nervous system (CNS) level, being neurotoxic by alteration of the neurotransmitter function. HA can be triggered by an inappropriate diet, infection or stress, but can also occur without a precise cause. In cases of metabolic crises, patients require immediately intensive care. In the last seven years (2011-2017), we cared in the Department of Genetics, "Dr...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Torri D Metz
This month we focus on current research in maternal heart disease. Dr. Metz discusses four recent publications, which are concluded with a "bottom-line" that is the take-home message. A complete reference for each can be found on Box 1 on this page along with direct links to abstracts.
December 4, 2018: Obstetrics and Gynecology
Wannakamon Panyarak, Toru Chikui, Yasuo Yamashita, Takeshi Kamitani, Kazunori Yoshiura
RATIONALE AND OBJECTIVES: We aimed to compare the distortion ratio (DR), signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) between turbo spin-echo (TSE)-diffusion-weighted imaging (DWI) and echo-planar imaging (EPI)-DWI of the orofacial region and prove the usefulness of TSE-DWI for the differential diagnosis of orofacial lesions. MATERIALS AND METHODS: The DR, SNR, and CNR of both sequences were compared in 42 cases. Then, the apparent diffusion coefficient (ADC) of various orofacial lesions obtained by TSE-DWI was investigated in 143 lesions...
December 6, 2018: Academic Radiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"