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https://www.readbyqxmd.com/read/30118505/predicting-acute-renal-failure-in-bothrops-snakebite-patients-in-a-tertiary-reference-center-western-brazilian-amazon
#1
Eliane Campos Alves, Jacqueline de Almeida Gonçalves Sachett, Vanderson Souza Sampaio, José Diego de Brito Sousa, Sâmella Silva de Oliveira, Elizandra Freitas do Nascimento, Alessandra Dos Santos Santos, Iran Mendonça da Silva, Ana Maria Moura da Silva, Fan Hui Wen, Mônica Colombini, Marcus Vinicius Guimarães de Lacerda, Wuelton Marcelo Monteiro, Luiz Carlos de Lima Ferreira
Acute Kidney Injury (AKI) is the main systemic complication and cause of death in viperid envenomation. Although there are hypotheses for the development of AKI, the mechanisms involved are still not established. The aim of this study was to evaluate the clinical-laboratorial-epidemiological factors associated with AKI in victims of Bothrops sp envenomation. This is an observational study carried out at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. AKI was defined according to the guidelines of the Acute Kidney Injury Network (AKIN)...
2018: PloS One
https://www.readbyqxmd.com/read/30116462/a-rare-case-of-co-existing-adrenal-and-pelvic-myelolipomas
#2
Dr Qasim Wadood, Dr Saad Ahmad Qureshi, Dr Pavel Singh, Dr Jonathan Freedman
We are reporting a case of co-existing left sided pelvic and right sided adrenal myelolipomas in a 68-year-old male patient. Both lesions were incidentally discovered on CT whilst undergoing a staging scan for suspected urinary bladder cancer. The patient had a background of hypertension and type 2 diabetes. Contrast enhanced CT scan showed both lesions to be of mixed fat and soft tissue density. Given the size, location, and attenuation characteristics of the pelvic mass, retroperitoneal liposarcoma was thought to be a differential diagnosis, prompting the decision for an elective CT-guided biopsy...
October 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/30116309/an-anatomical-study-of-the-spinous-process-of-the-seventh-cervical-vertebrae-based-on-the-three-dimensional-computed-tomography-reconstruction
#3
Lei Zhang, Zidan Luo, Hao Wang, Lin Ren, Fei Yu, Taiyuan Guan, Shijie Fu
Palpation of the seventh cervical vertebra (C7) is important for the diagnosis and treatment of neck and chest conditions. However, the spinous process of C7 (C7-SP) displays an anatomical deviation among individuals. The present study aimed to clarify anatomic characteristics of C7-SP by using a three-dimensional (3D) computed tomographic (CT) reconstruction technique. A total of 245 subjects meeting the selection criteria were examined. After CT scanning, the images were reconstructed in 3D. All subjects were grouped according to their deviation of C7-SP: Deviating to the right (DR group), deviating to the left (DL group) and no deviation (ND group)...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30113147/the-prevalence-and-risk-factors-for-diabetic-retinopathy-in-shiraz-southern-iran
#4
Haleh Ghaem, Nima Daneshi, Shirin Riahi, Mostafa Dianatinasab
Globally, diabetic retinopathy (DR) is one of the leading causes of blindness, that diminishes quality of life. This study aimed to describe the prevalence of DR, and its associated risk factors. This cross-sectional study was carried out among 478 diabetic patients in a referral center in Fars province, Iran. The mean±standard deviation age of the participants was 56.64±12.45 years old and DR prevalence was 32.8%. In multivariable analysis, lower education levels (adjusted odds ratio [aOR], 0.43; 95% confidence interval [CI], 0...
August 9, 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/30112685/truly-reconciling-the-case-of-jahi-mcmath
#5
EDITORIAL
D Alan Shewmon
This article clarifies some issues raised by Dr. Ariane Lewis in her recent "Current Opinion/Arguments" article on the case of Jahi McMath. Review of case materials. Jahi's case most likely represents an instance of global ischemic penumbra (GIP) mimicking brain death (BD), with intracranial blood flow too low to support neuronal function or to be detected by radionuclide scan but sufficient to prevent widespread necrosis. Her MRI scan 9 months after the ischemic insult showed gross preservation of cortical and internal structures, incompatible with there ever having been a period of completely absent blood flow...
August 15, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/30112316/mothers-preferences-toward-breaking-bad-news-about-their-children-cancer
#6
Zahra Mostafavian, Zahra Abbasi Shaye, Arezou Farajpour
Background: The responsibility of breaking bad news (BBN) to patients is one of the most difficult tasks of a medical profession. Aim: The current study aimed to investigate the preferences of mothers of children with cancer about BBN. Materials and Methods: In this cross-sectional study was conducted in Mashhad during years of 2016, 62 mothers of children with cancer at Dr-Sheikh hospital were recruited by convenience sampling and completed a questionnaire including demographic data and 20 questions about the mothers' preferences to BBN...
May 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/30111411/-prognostic-value-of-morphology-and-hans-classification-in-diffuse-large-b-cell-lymphoma
#7
Kai-Le Wang, Can Chen, Peng-Fei Shi, Jian-Hua Yu, Jun-Feng Tan, Shen-Xian Qian, Da-Quan Gao, Kuang Chen, Li-Rong Liu, Ya-Pin Xie, Ying Xu
OBJECTIVE: To investigate the prognostic value of morphology and Hans classification in diffuse large B cell lymphoma(DLBCL). METHODS: Clinical data of 249 patients diagnosed with DLBCL in our hospital and Hangzhou Xixi hospital during Jan 2006 to Dec 2016 were analyzed retrospectively. These patients were classified into 3 groups: immunoblastic variant(IB) group, centroblastic variant(CB) group and others group according to the cell morphology. And DLBCL was also divided into GCB(germinal center B-cell-like)or non-GCB(non-germinal center B-cell-like) group by analyzing the expression of CD10, BCL6 and MUM1 (GCB: CD10 + ,BCL6+- ,MUM1+- /CD10- ,BCL6+ ,MUM1- ;non-GCB:CD10- ,BCL6- ,MUM1+- /CD10- ,BCL6+ ,MUM1+ )...
August 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/30109508/an-intelligent-model-for-blood-vessel-segmentation-in-diagnosing-dr-using-cnn
#8
S N Sangeethaa, P Uma Maheswari
Diabetic retinopathy (DR) is an eye disease, which affects the people who are all having the diabetes for more than 10 years. The ophthalmologist identifies when the dilated eye exam causes severe in any one of the following deviations in the retina: changes in blood vessels, leaking blood vessels, newly grown blood vessels, swelling of the macula, changes in the lens, and damages to the nerve tissue. It can eventually lead to vision loss. The early detection of DR prevents the cause of blindness. In this paper, we propose the retinal image segmentation and extraction of blood vessels by morphological processing, thresholding, edge detection, and adaptive histogram equalization...
August 15, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/30109288/t-cell-epitopes-of-the-esxa-full-gene-of-mycobacterium-tuberculosis-from-sputum-of-mdr-tb-patients
#9
Desak Nyoman Surya Suameitria Dewi, Soedarsono, Ni Made Mertaniasih
Background: In 2015, World Health Organization (WHO) discovered 10.4 million tuberculosis (TB) cases around the world. Multidrug-resistant tuberculosis (MDR-TB) became a threat because it has high mortality number. There were 480,000 new MDR-TB cases in 2015. Based on those problems, diagnostic development to detect M. tuberculosis rapidly and accurately is needed. The importance of detecting epitope expression of esxA full gene because there was a potential of complexity over the protein structure and might affect the protein concentration...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/30109284/single-nucleotide-polymorphism-of-eccb-5-gene-of-mycobacterium-tuberculosis-complex-isolates-from-suspected-pulmonary-tb-patients-in-surabaya-indonesia
#10
Siti Kurniawati, Soedarsono Soedarsono, Aulanni'am Aulanni'am, Ni Made Mertaniasih
Background: Mycobacterium tuberculosis Complex (MTBC) is a group of Mycobacterium that causes tuberculosis (TB). TB is an infectious disease that remains a global health problem. Indonesia is one of the five countries in the world where TB is the most prevalent and became the country with tle second largest rate of TB in 2014 and 2015. MTBC has high pathogenicity that can cause infections in animals and humans. The most common route of transmission is via airborne droplet nuclei and contact with animals or humans infected with TB...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/30107763/dr-google-in-the-ed-searching-for-online-health-information-by-adult-emergency-department-patients
#11
Anthony M Cocco, Rachel Zordan, David McD Taylor, Tracey J Weiland, Stuart J Dilley, Joyce Kant, Mahesha Dombagolla, Andreas Hendarto, Fiona Lai, Jennie Hutton
OBJECTIVE: To determine the prevalence, predictors, and characteristics of health-related internet searches by adult emergency department (ED) patients; to examine the effect of searching on the doctor-patient relationship and treatment compliance. DESIGN: A multi-centre, observational, cross-sectional study; a purpose-designed 51-item survey, including tools for assessing e-health literacy (eHEALS) and the effects of internet searching on the doctor-patient relationship (ISMII)...
August 20, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/30107653/-the-current-situation-of-ophthalmologic-examination-and-treatment-of-diabetic-patients-in-a-community-of-fushun
#12
L Wen, X Sun, F H Wang, W Luo, K M Feng, Y Xue, G Y Mao, Y Wang, Y B Liang, G Zhai, C Xie, N L Wang
Objective: To investigate the attainment of therapeutic targets for glycosylated hemoglobin and blood pressure, ophthalmologic examination, diagnosis and treatment of diabetic retinopathy (DR) with type 2 diabetes mellitus. Methods: A cross-sectional study in type 2 diabetic patients was conducted in a community of Fushun between July 2012 and May 2013. Questionnaire, detailed ophthalmic examination and laboratory tests were completed to collect the information about sociodemographic and healthcare characteristics...
August 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/30107127/%C3%AE-cyclodextrin-functionalized-chitosan-alginate-compact-polyelectrolyte-complexes-copecs-as-functional-biomaterials-with-anti-inflammatory-properties
#13
Alexandre Hardy, Cendrine Seguin, Anaïs Brion, Philippe Lavalle, Pierre Schaaf, Sylvie Fournel, Line Bourel-Bonnet, Benoit Frisch, Dr Marcella De Giorgi
Nowadays, the need for therapeutic biomaterials displaying anti-inflammatory properties to fight against inflammation-related diseases is continuously increasing. Compact PolyElectrolyte Complexes (CoPECs) represent a new class of materials obtained by ultracentrifugation of a polyanion/polycation complexes suspension in the presence of salt. Here, a non-cytotoxic β-cyclodextrin-functionalized chitosan/alginate CoPEC was formulated, characterized and described as a promising drug carrier displaying an intrinsic anti-inflammatory property...
August 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30103233/higher-detection-rates-of-biologically-aggressive-breast-cancers-in-mammography-screening-than-in-the-biennial-interval
#14
Anna Prange, Beate Bokhof, Philipp Polzer, Joke Tio, Isabel Radke, Oliver Heidinger, Walter Heindel, Stefanie Weigel
PURPOSE:  Assessment of age group-dependent detection rates of invasive breast cancers among participants in mammography screening including the interval, classified into immunohistochemical subtypes indicating the intrinsic tumor aggressiveness. MATERIALS UND METHODS:  The target population comprises women aged 50 - 69 years. All invasive breast cancers diagnosed in one screening (sc) unit during the implementation phase 1/2006 - 12/2010 or identified by the cancer registry during the biennial interval (iv) were categorized based on hormonal-receptor status (HR) and Her2-expression (Her2) into the following subtypes: a) HR+ Her2-, b) HR+ Her2 +, c) HR- Her2 + or d) HR- Her2- (triple-negative); Her2 + and triple-negative types were defined as aggressive...
August 13, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/30099489/immunotherapy-with-apitopes-blocks-the-immune-response-to-thyroid-stimulating-hormone-receptor-in-hla-dr-transgenic-mice
#15
Lotta Jansson, Kathleen Vrolix, Andrea Jahraus, Keith F Martin, David C Wraith
We have combined MHC binding assays with immunization and tolerance induction experiments in HLA-DR3 transgenic mice in order to design apitopes (Antigen Processing Independent epiTOPES) derived from TSHR for treatment of patients with Graves' disease (GD). A challenge model was created by using an adenovirus expressing part of the extracellular domain of the thyrotropin receptor (TSHR289). This model was used to test whether current drug treatments for GD would impact on effective antigen-specific immunotherapy using the apitope approach...
August 6, 2018: Endocrinology
https://www.readbyqxmd.com/read/30098888/associations-between-recent-and-established-ophthalmic-conditions-and-risk-of-alzheimer-s-disease
#16
Cecilia S Lee, Eric B Larson, Laura E Gibbons, Aaron Y Lee, Susan M McCurry, James D Bowen, Wayne C McCormick, Paul K Crane
INTRODUCTION: Identifying ophthalmic diseases associated with increased risk of Alzheimer's disease (AD) may enable better screening and understanding of those at risk of AD. METHODS: Diagnoses of glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR) were based on International Classification of Diseases, 9th revision, codes for 3877 participants from the Adult Changes in Thought study. The adjusted hazard ratio for developing probable or possible AD for recent (within 5 years) and established (>5 years) diagnoses were assessed...
August 2, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/30098212/breast-ultrasonography-in-the-screening-protocol-for-women-at-hereditary-familial-risk-of-breast-cancer-has-the-time-come-to-rethink-the-role-of-bu-according-to-different-risk-categories
#17
L Cortesi, B Canossi, R Battista, A Pecchi, A Drago, C Dal Molin, A Toss, E De Matteis, I Marchi, P Torricelli, S Cascinu
This paper evaluates the breast cancer (BC) screening efficacy of biannual ultrasound (US) in three different risk categories. In a single-center, prospective, nonrandomized comparison study, BRCA mutation carriers and women with high risk (HR) or intermediate risk (IR) received mammography (MMG), ultrasound, (US) and Magnetic Resonance Imaging (MRI), scheduled according to the risk categories. Single and combined sensitivity were evaluated in specific groups of risk and the US performance at six-monthly interval was notably considered...
August 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30097790/correction-to-prognostic-influence-of-prior-chronic-obstructive-pulmonary-disease-in-patients-admitted-for-their-first-episode-of-acute-heart-failure
#18
Karine Luz Londoño, Francesc Formiga, David Chivite, Rafael Moreno-Gonzalez, Margherita Migone De Amicis, Xavier Corbella
In the original publication, the given name and family name of the fifth author Dr Margherita Migone De Amicis were incorrectly published. The correct given name and family name should read as 'Margherita' and 'Migone De Amicis', respectively.
August 10, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/30097607/combined-quantification-of-procalcitonin-and-hla-dr-improves-sepsis-detection-in-surgical-patients
#19
Raquel Almansa, Silvia Martín, Marta Martin-Fernandez, María Heredia-Rodríguez, Esther Gómez-Sánchez, Marta Aragón, Cristina Andrés, Dolores Calvo, Jesus Rico-Feijoo, Maria Carmen Esteban-Velasco, Luis Mario Vaquero-Roncero, Alicia Ortega, Estefania Gómez-Pesquera, Mario Lorenzo-López, Iñigo López de Cenarruzabeitia, Diana Benavides, Jaime López-Sanchez, Cristina Doncel, Carmen González-Sanchez, Esther Zarca, Alberto Ríos-Llorente, Agustín Diaz, Elisa Sanchez-Barrado, Juan Beltran de Heredia, Jose Maria Calvo-Vecino, Luis Muñoz-Bellvís, Jose Ignacio Gomez-Herreras, César Aldecoa, Eduardo Tamayo, Jesus F Bermejo-Martin
Early recognition of sepsis is a key factor to improve survival to this disease in surgical patients, since it allows prompt control of the infectious source. Combining pro-inflammatory and immunosupression biomarkers could represent a good strategy to improve sepsis detection. Here we evaluated the combination of procalcitonin (PCT) with gene expression levels of HLA-DRA to detect sepsis in a cohort of 154 surgical patients (101 with sepsis and 53 with no infection). HLA-DRA expression was quantified using droplet digital PCR, a next-generation PCR technology...
August 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30092732/damage-accrual-in-systemic-lupus-erythematosus-in-dominicans-in-new-york-city-and-the-dominican-republic
#20
L Geraldino-Pardilla, T Kapoor, I Canto, T Perez-Recio, J Then, C Tineo, E Loyo, A Askanase
Objectives Hispanics with systemic lupus erythematosus (SLE) in the United States have more severe disease and damage accrual compared with whites. Data on Hispanics of similar ancestry in geographically different locations is limited but essential in defining genetic and environmental factors for SLE. This study evaluates SLE disease burden in two Dominican communities, Washington Heights in New York City (NYC) and Santiago in the Dominican Republic (DR). Methods Disease activity (SLE Disease Activity Index 2000 (SLEDAI-2K)) and damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)) were cross-sectionally measured in 76 Dominican SLE patients from the Columbia University Lupus Cohort in NYC and compared with 75 Dominican SLE patients living in Santiago in the DR...
August 9, 2018: Lupus
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