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Li Hua Jin

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https://www.readbyqxmd.com/read/30511962/apc-activated-long-non-coding-rna-inhibits-colorectal-carcinoma-pathogenesis-through-reducing-exosome-production
#1
Feng-Wei Wang, Chen-Hui Cao, Kai Han, Yong-Xiang Zhao, Mu-Yan Cai, Zhi-Cheng Xiang, Jia-Xing Zhang, Jie-Wei Chen, Li-Ping Zhong, Yong Huang, Su-Fang Zhou, Xiao-Han Jin, Xin-Yuan Guan, Rui-Hua Xu, Dan Xie
The adenomatous polyposis coli (APC) gene plays a pivotal role in the pathogenesis of colorectal carcinoma (CRC), but remains a challenge for drug development. Long non-coding RNAs (lncRNAs) are invaluable in identifying cancer pathologies, and providing therapeutic options for cancer patients. Here, we identified a lncRNA (lncRNA-APC1) activated by APC through lncRNA microarray screening, and examined its expression among a large cohort of CRC tissues. A decrease in lncRNA-APC1 expression was positively associated with lymph node and/or distant metastasis, a more advanced clinical stage, as well as a poor prognosis of CRC patients...
December 4, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30511679/efficacy-and-safety-of-teriflunomide-in-chinese-patients-with-relapsing-forms-of-multiple-sclerosis-a-subgroup-analysis-of-the-phase-3-tower-study
#2
Wei Qiu, De-Hui Huang, Shi-Fang Hou, Mei-Ni Zhang, Tao Jin, Hui-Qing Dong, Hua Peng, Chao-Dong Zhang, Gang Zhao, Yi-Ning Huang, Dong Zhou, Wei-Ping Wu, Bao-Jun Wang, Ji-Mei Li, Xing-Hu Zhang, Yan Cheng, Hai-Feng Li, Ling Li, Chuan-Zhen Lu, Xu Zhang, Bi-Tao Bu, Wan-Li Dong, Dong-Sheng Fan, Xue-Qiang Hu, Xian-Hao Xu
Background: Disease-modifying therapy is the standard treatment for patients with multiple sclerosis (MS) in remission. The primary objective of the current analysis was to assess the efficacy and safety of two teriflunomide doses (7 mg and 14 mg) in the subgroup of Chinese patients with relapsing MS included in the TOWER study. Methods: TOWER was a multicenter, multinational, randomized, double-blind, parallel-group (three groups), placebo-controlled study. This subgroup analysis includes 148 Chinese patients randomized to receive either teriflunomide 7 mg (n = 51), teriflunomide 14 mg (n = 43), or placebo (n = 54)...
December 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/30502698/polyurethane-epoxy-resin-and-polydimethylsiloxane-altered-biofilm-formation-and-mussel-settlement
#3
Xiao Liang, Li-Hua Peng, Shuo Zhang, Shuxue Zhou, Asami Yoshida, Kiyoshi Osatomi, Nikoleta Bellou, Xing-Pan Guo, Sergey Dobretsov, Jin-Long Yang
In many environments, biofilms are a major mode and an emergent form of microbial life. Biofilms play crucial roles in biogeochemical cycling and invertebrate recruitment in marine environments. However, relatively little is known about how marine biofilms form on different substrata and about how these biofilms impact invertebrate recruitment. Here, we performed a comparative analysis of a 28-day-old biofilm community on non-coated (a control glass) and coated substrata (polyurethane (PU), epoxy resin (EP) and polydimethylsiloxane (PDMS)) and examined the settlement of Mytilus coruscus plantigrades on these biofilms...
November 20, 2018: Chemosphere
https://www.readbyqxmd.com/read/30498207/altered-gut-microbiota-after-traumatic-splenectomy-is-associated-with-endotoxemia
#4
Hua Zhu, Yang Liu, Shengda Li, Ye Jin, Lei Zhao, Fuya Zhao, Jing Feng, Wei Yan, Yunwei Wei
Splenectomy carries a long-term risk of postoperative infection, and the chronic, low-grade inflammation associated with endotoxemia may be related to the gut microbiota. In this study, to increase our understanding of the potential cause of the high rate of infection in postsplenectomy patients, we evaluated the differences in the gut microbiota and plasma lipopolysaccharide level of patients after splenectomy relative to those of healthy controls. Thirty-two patients having undergone splenectomy and 42 healthy individuals were enrolled into the splenectomy (SP) and healthy control (HC) groups, respectively...
November 30, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/30497264/inhibition-of-p2x7r-nlrp3-inflammasome-activation-by-pleurotus-citrinopileatus-a-possible-protective-role-in-alcoholic-hepatosteatosis
#5
Xia Li, Quan Jin, Yu Zhang, Yan-Ling Wu, Cheng-Min Jin, Ben-Wen Cui, Ying Li, Ming-Ji Jin, Yue Shang, Min Jiang, Hong-Xu Yang, Mei Wu, Jian Liu, Li-Hua Lian, Ji-Xing Nan
Pleurotus citrinopileatus (golden oyster mushroom) is a widely used edible mushroom. We investigated the inhibitory effect of P. citrinopileatus aqueous extract against alcoholic steatohepatitis and its underlying mechanism. Acute and chronic ethanol feeding murine models were established by intragastrically administering ethanol or feeding ethanol-containing Lieber-DeCarli liquid diet to male C57BL/6 mice. In both models, P. citrinopileatus decreased serum alanine aminotransferase (ALT), aspartate transaminase (AST), triglyceride (TG) and hepatic TG levels...
November 29, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/30496347/comprehensive-review-of-the-identification-of-essential-genes-using-computational-methods-focusing-on-feature-implementation-and-assessment
#6
Chuan Dong, Yan-Ting Jin, Hong-Li Hua, Qing-Feng Wen, Sen Luo, Wen-Xin Zheng, Feng-Biao Guo
Essential genes have attracted increasing attention in recent years due to the important functions of these genes in organisms. Among the methods used to identify the essential genes, accurate and efficient computational methods can make up for the deficiencies of expensive and time-consuming experimental technologies. In this review, we have collected researches on essential gene predictions in prokaryotes and eukaryotes and summarized the five predominant types of features used in these studies. The five types of features include evolutionary conservation, domain information, network topology, sequence component and expression level...
November 29, 2018: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/30489656/highly-improved-cycling-stability-of-anion-de-intercalation-in-the-graphite-cathode-for-dual-ion-batteries
#7
Wen-Hao Li, Qiu-Li Ning, Xiao-Tong Xi, Bao-Hua Hou, Jin-Zhi Guo, Yang Yang, Bin Chen, Xing-Long Wu
Conventional ion batteries utilizing metallic ions as the single charge carriers are limited by the insufficient abundance of metal resources. Although supercapacitors apply both cations and anions to store energy through absorption and/or Faradic reactions occurring at the interfaces of the electrode/electrolyte, the inherent low energy density hinders its application. The graphite-cathode-based dual-ion battery possesses a higher energy density due to its high working potential of nearly 5 V. However, such a battery configuration suffers from severe electrolyte decomposition and exfoliation of the graphite cathode, rendering an inferior cycle life...
November 29, 2018: Advanced Materials
https://www.readbyqxmd.com/read/30486280/effect-of-sn-content-on-the-microstructure-mechanical-properties-and-corrosion-behavior-of-biodegradable-mg%C3%A2-x-1-3-and-5-wt-sn%C3%A2-1zn%C3%A2-0-5ca-alloys
#8
Zheng-Xue Zhao, Zhen-Ming Hua, Da-Wei Li, Dong-Song Wei, Yan Liu, Jin-Guo Wang, Dan Luo, Hui-Yuan Wang
The microstructure, mechanical properties and corrosion behavior of hot⁻rolled Mg⁻xSn⁻1Zn⁻0.5Ca (x = 1, 3 and 5 wt.%) alloys were investigated for possible application as biodegradable implants. The hot⁻rolled Mg⁻xSn⁻1Zn⁻0.5Ca alloys consisted of α-Mg matrix and Mg₂Sn phase. The number of the Mg₂Sn particles significantly increased and the grains were gradually refined (14.2 ± 1.5, ~10.7 ± 0.7 and ~6.6 ± 1.1 μm), while the recrystallized fraction significantly decreased with the increase in the Sn content, the Mg⁻1Sn⁻1Zn⁻0...
November 26, 2018: Materials
https://www.readbyqxmd.com/read/30484290/preoperative-th1-th2-and-related-cytokines-prediction-value-in-postoperative-febrile-uti-after-ureteroscopy-in-patients-with-ureteral-calculi
#9
Zhen Li, Kang-Er Wang, Xie-Lai Zhou, Jin Zhou, Chun-Hua Ye
BACKGROUND: The topic of whether preoperative Th1/Th2 cells and their related factors have a predictive value for postoperative febrile urinary tract infection (UTI) in patients with ureteral calculi has not been explored. OBJECTIVES: The objective of this study was to investigate the role of preoperative Th1/Th2 cells and related cytokines in the prediction of postoperative febrile UTI after ureteroscopy in patients with ureteral calculi. MATERIAL AND METHODS: One hundred sixty patients who underwent ureteroscopic pneumatic lithotripsy in the Affiliated Hospital of Hangzhou Normal University (China) were recruited and divided into febrile UTI group (n = 78) and non-UTI group (n = 82)...
November 28, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30482197/increased-glycated-albumin-and-decreased-esrage-levels-in-serum-are-related-to-negative-coronary-artery-remodeling-in-patients-with-type-2-diabetes-an-intravascular-ultrasound-study
#10
Run Du, Rui Yan Zhang, Lin Lu, Ying Shen, Li Jin Pu, Zheng Bin Zhu, Qi Zhang, Jian Hu, Zhen Kun Yang, Feng Hua Ding, Jian Sheng Zhang, Wei Feng Shen
BACKGROUND: Negative coronary artery remodeling is frequent in patients with diabetes, but its mechanism remains unclear. We here evaluated the association of serum levels of glycated albumin (GA) and endogenous secretory receptor for advanced glycation end products (esRAGE) with coronary artery remodeling in type 2 diabetic patients. METHODS: Serum levels of GA and esRAGE were measured and intravascular ultrasound was performed in 136 consecutive diabetic patients with 143 coronary intermediate lesions...
November 27, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/30479882/toxicity-of-melaleuca-alternifolia-essential-oil-to-the-mitochondrion-and-nad-nadh-dehydrogenase-in-tribolium-confusum
#11
Min Liao, Qian-Qian Yang, Jin-Jing Xiao, Yong Huang, Li-Jun Zhou, Ri-Mao Hua, Hai-Qun Cao
Background: In our previous study, Melaleuca alternifolia essential oil (EO) was considered to have an insecticidal effect by acting on the mitochondrial respiratory chain in insects. However, the mode of action is not fully understood. Methods: In this study, we investigated the insecticidal efficacy of the M. alternifolia EO against another major stored-product pest, Tribolium confusum Jacquelin du Val. Rarefaction and vacuolization of the mitochondrial matrix were evident in oil-fumigated T...
2018: PeerJ
https://www.readbyqxmd.com/read/30476039/doublesex-evolution-is-correlated-with-social-complexity-in-ants
#12
Ling-Yi Jia, Li Chen, Laurent Keller, John Wang, Jin-Hua Xiao, Da-Wei Huang
The Dmrt (Doublesex and Mab-3 Related Transcription factor) genes are transcription factors crucial for sex determination and sexual differentiation. In some social insects, Doublesex (dsx) exhibits widespread caste-specific expression across different tissues and developmental stages and has been suggested as a candidate gene for regulating division of labor in social insects. We therefore conducted a molecular evolution analysis of the Dmrt gene family in 20 ants. We found that the insect-specific oligomerization domain of DSX, oligomerization domain 2 (OD2), was absent in all ants, except for the two phylogenetically basal ant species (Ponerinae), whose social structure and organization resemble the presumed ancestral condition in ants...
November 22, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/30474453/association-between-serum-progesterone-concentration-in-early-pregnancy-and-duration-of-pregnancy-a-cohort-study
#13
Song-Ying Shen, Qiao-Zhu Chen, Li-Fang Zhang, Jian-Rong He, Jin-Hua Lu, Wei-Dong Li, Wan-Qing Xiao, Ze-Hong Zhou, Abraham N Morse, Kar Keung Cheng, Ben Willem J Mol, Hui-Min Xia, Xiu Qiu
OBJECTIVE: To examine the association between progesterone concentration in early pregnancy and duration of pregnancy and risk of preterm delivery. METHODS: Women enrolled in the Born in Guangzhou Cohort Study from 2013-2014, with a singleton pregnancy, who had serum progesterone measured at least one time between 4 and 10 weeks of gestation were included. The association between progesterone concentration both continuous and as categorical variable (quartile) and the risk of preterm delivery was assessed with Cox proportional hazards regression...
November 25, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30474438/prescribing-patterns-and-healthcare-costs-of-gout
#14
Yi-Yun Lee, Li-Na Kuo, Jin-Hua Chen, Yi-Chun Lin, Lung-Fang Chen, Yu Ko
The Longitudinal Health Insurance Database (LHID) 2010 was used to identify gout cases and their number of gout flares. Out of 21,376 gout patients, a total of 3,561 (16.7%) had frequent gout flares (> = 3 gout flares/year). Average all-cause healthcare utilization (35.9 visits vs. 30.7 visits; P < 0.001) and gout-related utilization (22.7 visits vs. 15.6 visits; p < 0.001) were higher in frequent gout flare patients than in those with infrequent gout flares. The median gout-related cost (USD $369 vs...
November 26, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30473266/corrigendum-to-chinese-version-of-the-clinical-learning-environment-comparison-survey-assessment-of-reliability-and-validity-nurse-education-today-volume-71-december-2018-pages-121-128
#15
Yao-Hua Gu, Li Xiong, Jin-Bing Bai, Jing Hu, Xiao-Dong Tan
No abstract text is available yet for this article.
December 2018: Nurse Education Today
https://www.readbyqxmd.com/read/30472262/mnp-triggers-nasal-allergy-by-modulating-dendritic-cell-properties
#16
Xiao-Yu Liu, Yong-Jin Wu, Li-Juan Song, Xian-Hai Zeng, Shuai Wang, Jiang-Qi Liu, Li-Hua Mo, Xiao-Rui Geng, Li-Teng Yang, Rui-Di Xie, Xiao-Wen Zhang, Zhi-Gang Liu, Ping-Chang Yang
Exposure to MNP generates Th2 response-inducing dendritic cells. Transfer of OVA/MNP-primed dendritic cells induces nasal allergy. Inhibition of Bcl2L12 prevents nasal allergy development.
November 22, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30472188/otub2-promotes-cancer-metastasis-via-hippo-independent-activation-of-yap-and-taz
#17
Zhengkui Zhang, Jinjin Du, Shuai Wang, Li Shao, Ke Jin, Fang Li, Bajin Wei, Wei Ding, Peifen Fu, Hans van Dam, Aijun Wang, Jin Jin, Chen Ding, Bing Yang, Min Zheng, Xin-Hua Feng, Kun-Liang Guan, Long Zhang
The transcriptional regulators YAP and TAZ play important roles in development, physiology, and tumorigenesis and are negatively controlled by the Hippo pathway. It is yet unknown why the YAP/ TAZ proteins are frequently activated in human malignancies in which the Hippo pathway is still active. Here, by a gain-of-function cancer metastasis screen, we discovered OTUB2 as a cancer stemness and metastasis-promoting factor that deubiquitinates and activates YAP/TAZ. We found OTUB2 to be poly-SUMOylated on lysine 233, and this SUMOylation enables it to bind YAP/TAZ...
November 21, 2018: Molecular Cell
https://www.readbyqxmd.com/read/30471759/investigation-of-psoriasis-susceptibility-loci-in-psoriatic-arthritis-and-a-generalized-pustular-psoriasis-cohort
#18
Zheng Zhang, Jin-Hua Xu
Psoriasis is a common skin disease affecting 1-3% of the population (Gelfand et al., 2005; Ferrándiz et al., 2001). Approximately 30% of patients with psoriasis develop psoriatic arthritis (PsA), an inflammatory arthritis associated with psoriasis (Haroon et al., 2013; Prey et al., 2010). Generalized pustular psoriasis (GPP) affects about 1.3% of psoriasis patients. Recently, numerous novel susceptibility loci for psoriasis vulgaris (PsV) have been discovered thorough the application of genome-wide association studies (GWASs)...
December 2018: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/30469679/displaceable-and-focus-tunable-electrowetting-optofluidic-lens
#19
Lei Li, Jin-Hui Wang, Qiong-Hua Wang, Shin-Tson Wu
A conventional optofluidic lens usually has one liquid-liquid (L-L) interface, which can be deformed to achieve variable focal length. Such a single lens cannot be used alone to realize optical zooming because its back focal distance keeps changing. Here, we report a novel displaceable and focus-tunable electrowetting optofluidic lens. In comparison with the conventional optofluidic lens, our new lens has a different working principle and it can function as an optical zoom lens. The L-L interface can be displaced by a voltage...
October 1, 2018: Optics Express
https://www.readbyqxmd.com/read/30465826/low-expression-of-pdk1-inhibits-renal-cell-carcinoma-cell-proliferation-migration-invasion-and-epithelial-mesenchymal-transition-through-inhibition-of-the-pi3k-pdk1-akt-pathway
#20
Wei-Min Zhou, Gao-Liang Wu, Ji Huang, Jin-Gao Li, Chao Hao, Qiu-Ming He, Xiao-Dan Chen, Gong-Xian Wang, Xin-Hua Tu
As the most commonly occurring form of primary renal tumor, renal cell carcinoma (RCC) is a malignancy accompanied by a high mortality rate. 3-phosphoinositide-dependent protein kinase 1 (PDK1) has been established as a protein target and generated considerable interest in both the pharmaceutical and academia industry. The aim of the current study was to investigate the effect of si-PDK1 on the RCC cell apoptosis, proliferation, migration, invasion and epithelial mesenchymal transition (EMT) in connection with the PI3K-PDK1-Akt pathway...
November 19, 2018: Cellular Signalling
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