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Li Hua Jin

Jian-Kun Sun, Sheng Huang, Xiao-Zhi Liu, Quan Xu, Qing-Hua Zhang, Wen-Jie Jiang, Ding-Jiang Xue, Jia-Chao Xu, Jing-Yuan Ma, Jie Ding, Qian-Qing Ge, Lin Gu, Xiaohong Fang, Hai-Zheng Zhong, Jin-Song Hu, Li-Jun Wan
Despite the recent surge of interest in inorganic lead halide perovskite nanocrystals, there are still significant gaps in their stability disturbance and the understanding of their destabilization, assembly, and growth processes. Here, we discover that polar solvent molecules can induce the lattice distortion of ligand-stabilized cubic CsPbI3, leading to the phase transition into orthorhombic phase which is unfavorable for photovoltaic applications. Such lattice distortion triggers the dipole moment on CsPbI3 nanocubes, which subsequently initiates the hierarchical self-assembly of CsPbI3 nanocubes into single-crystalline nanowires...
August 15, 2018: Journal of the American Chemical Society
Jian-Liang Pan, Jin Gao, Jian-Hua Hou, De-Zhong Hu, Lin Li
BACKGROUND Various studies have highlighted the link between polymorphisms in the XRCC1 gene (encoding X-ray repair cross-complementing group 1) with the incidence of decreased DNA repair capacity and an increased predisposition to cancer. Catechol-O-methyltransferase (COMT) plays a crucial role in estrogen-induced cancers. In the present study was analyzed the potential influence of XRCC1 and COMT gene polymorphisms as predisposing factors from a lung cancer perspective, in addition to conducting an investigation into their interaction with environmental risk factors in relation to lung cancer among non-smoking Chinese women...
August 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Hua-Wei Wang, Yi-Heng Yin, Ya-Zhou Jin, Rui Zong, Teng Li, Guang-Yu Qiao, Xin-Guang Yu
OBJECTIVE: Unfamiliarity with the morphometry of assimilated C1 lateral mass(C1LM) could make screw placement dangerous. In the study, we define the morphometric dimensions of occipitalized C1LM so as to provide surgeons with valuable information for preoperative planning. METHODS: Thin-slice computed tomography scanning data of 131 OA patients and 50 control cases were imported into MIMICS software for analysis. The widths and heights of C1LM were fully measured in different planes...
August 11, 2018: World Neurosurgery
Shang Dai, Ye Jin, Tao Li, Yulan Weng, Xiaolin Xu, Genlin Zhang, Jiulong Li, Renjiang Pang, Bing Tian, Yuejin Hua
Iron acquisition by bacteria is well studied, but iron export from bacteria is less understood. Herein, we identified dr1440 with a P-type ATPase motif as a potential exporter of iron from Deinococcus radiodurans, a bacterium known for its extreme resistance to radiation and oxidants. The DR1440 was located in cell membrane as demonstrated by fluorescence labelling analysis. Mutation of dr1440 resulted in cellular accumulation of iron ions, and expression level of dr1440 was up-regulated significantly under iron ion or hydrogen peroxide stress in the wild-type strain, implicating DR1440 as a potential iron efflux protein...
2018: PloS One
Zi-Qi Jin, Jian Hao, Xue Yang, Jing-Hua He, Jing Liang, Jin-Wei Yuan, Yu Mao, Dan Liu, Rui Cao, Xiong-Zhi Wu, Xin Li, Dan Chen
Cucurbitacin B (Cu B), a tetracyclic triterpenoid derived from Trichosanthes kirilowii Maxim, exhibits anticancer effects against various types of tumor. Higenamine, isolated from Radix Aconiti Lateralis Preparata, has been used as a dietary supplement for regulating metabolic function. The present study suggested that higenamine enhances Cu B-induced cytotoxicity in breast cancer cells and in vivo. Network pharmacology analysis was used to identify the possible mechanism of action. Cu B alone inhibited breast cancer cell growth, induced apoptosis, and arrested the cell cycle in the G2/M phase...
August 6, 2018: Oncology Reports
Xiao-Jun Wang, Li-Hui Chen, Albrecht W Hofmann, Takeshi Hanyu, Hiroshi Kawabata, Yuan Zhong, Lie-Wen Xie, Jin-Hua Shi, Takashi Miyazaki, Yuka Hirahara, Toshiro Takahashi, Ryoko Senda, Qing Chang, Bogdan S Vaglarov, Jun-Ichi Kimura
The extreme Sr, Nd, Hf, and Pb isotopic compositions found in Pitcairn Island basalts have been labeled enriched mantle 1 (EM1), characterizing them as one of the isotopic mantle end members. The EM1 origin has been vigorously debated for over 25 years, with interpretations ranging from delaminated subcontinental lithosphere, to recycled lower continental crust, to recycled oceanic crust carrying ancient pelagic sediments, all of which may potentially generate the requisite radiogenic isotopic composition. Here we find that δ26 Mg ratios in Pitcairn EM1 basalts are significantly lower than in normal mantle and are the lowest values so far recorded in oceanic basalts...
August 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
Xin Li, Zhongxian Tian, Honglei Jin, Jiheng Xu, Xiaohui Hua, Huiying Yan, Huating Liufu, Jingjing Wang, Jingxia Li, Junlan Zhu, Haishan Huang, Chuanshu Huang
Bladder cancer (BC) ranks as the sixth most common cancer in the United States and is the leading cause of death in patients with urinary malignancies. p63 is a member of the p53 family and is believed to function as a tumor suppressor in human BCs. Our most recent studies reveal a previously unknown function of the RING of XIAP in promoting miR-4295 transcription, thereby reducing p63α protein translation and enhancing normal urothelial transformation, whereas p63α upregulates hsp70 transcription, subsequently activating the HSP70/Wasf3/Wave3/MMP-9 axis, and promoting BC cell invasion via initiating the transcription factor E2F1...
August 13, 2018: Molecular and Cellular Biology
Li-Jun Li, Feng Chang, Yong Hai, Jin-Cai Yang, Cheng Xu, Jie Yuan, Jiu-Qiang Sun, Qing-Hua Wang, Sheng-Qiang Ding
OBJECTIVE: To evaluate clinical effects of lumbar spinal stenosis by endoscopic transforaminal decompression, and to provide a theory basis for selection of surgical candidates. METHODS: From June 2014 to January 2016, clinical data of 87 patients with lumbar spinal stenosis were retrospectively analyzed, including 45 males and 42 females, aged from 25 to 81 years old with an average of 55.14 years old; 8 cases on L₃,₄, 61 cases on L₄,₅, 18 cases on L₅S₁...
July 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Yue Shang, Xi-Feng Li, Ming-Ji Jin, Ying Li, Yan-Ling Wu, Quan Jin, Yu Zhang, Xia Li, Min Jiang, Ben-Wen Cui, Li-Hua Lian, Ji-Xing Nan
The current study was aimed to reveal that leucodin, a sesquiterpene lactone from Artemisia capillaris could inhibit the inflammatory response in macrophages and the lipid accumulation in hepatocytes via P2x7R-NLRP3 inflammasome activation. Several types of macrophages including mouse peritoneal macrophages, mouse bone marrow-derived macrophages and human macrophages THP-1 cells were pretreated with different concentrations of leucodin for 1 h and then stimulated with LPS and ATP. LPS plus ATP initiated IL-1β cleavage and release in mouse peritoneal macrophages and peaked at 4 h...
August 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jin-Hua Liao, Rong-Fang Hu, Li-Jing Su, Shuo Wang, Qin Xu, Xiao-Fang Qian, Hong-Gu He
BACKGROUND: Nonpharmacological interventions are often used to promote sleep among preterm infants in the neonatal intensive care unit (NICU). However, there is a lack of synthesis in the evidence of their effectiveness. AIM: To synthesize the evidence on the effectiveness of nonpharmacological interventions on NICU preterm infants' sleep during hospital stay. METHODS: Seven databases were searched, including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Wan-fang database, China National Knowledge Infrastructure, China Biological Medicine Database, and VIP Journal Integration Platform from their inceptions to August 2017...
August 11, 2018: Worldviews on Evidence-based Nursing
Ting Zheng, Peng-Fei Qi, Yong-Li Cao, Ya-Nan Han, Hong-Liang Ma, Zhen-Ru Guo, Yan Wang, Yuan-Yuan Qiao, Shi-Yu Hua, Hai-Yue Yu, Jiang-Ping Wang, Jing Zhu, Cai-Yi Zhou, Ya-Zhou Zhang, Qing Chen, Li Kong, Ji-Rui Wang, Qian-Tao Jiang, Ze-Hong Yan, Xiu-Jin Lan, Gao-Qiong Fan, Yu-Ming Wei, You-Liang Zheng
Basis for the effects of nitrogen (N) on wheat grain storage proteins (GSPs) and on the establishment of processing quality are far from clear. The response of GSPs and processing quality parameters to four N levels of four common wheat cultivars were investigated at two sites over two growing seasons. Except gluten index (GI), processing quality parameters as well as GSPs quantities were remarkably improved by increasing N level. N level explained 4.2~59.2% and 10.4~80.0% variability in GSPs fractions and processing quality parameters, respectively...
August 9, 2018: Scientific Reports
Yan Xu, Jian-Fei Fu, Jia-Hui Chen, Zhuang-Wei Zhang, Zu-Quan Zou, Li-Yuan Han, Qi-Hang Hua, Jin-Shun Zhao, Xiao-Hong Zhang, Yu-Juan Shan
Sulforaphane (SFN) is a dietary component with multiple bioactivities; however, its role in obesity-related metabolic derangement remains unclear. Here, the effect of SFN on the glucose intolerance of obese mice and the underlying mechanism were determined. C57B/6J male mice were randomly divided into two groups, having free access to water and a normal-fat diet (ND, n = 6) or a high-fat diet (HFD, n = 33) for 8 weeks; thereafter twelve mice having the greatest weight gain among the HFD-fed mice were considered as obese mice...
August 9, 2018: Food & Function
Xiaoyan Yu, Yimin Lao, Xiao-Lu Teng, Song Li, Yan Zhou, Feixiang Wang, Xinwei Guo, Siyu Deng, Yuzhou Chang, Xuefeng Wu, Zhiduo Liu, Lei Chen, Li-Ming Lu, Jinke Cheng, Bin Li, Bing Su, Jin Jiang, Hua-Bing Li, Chuanxin Huang, Jing Yi, Qiang Zou
Regulatory T (Treg) cells are essential for maintaining immune homeostasis and tolerance, but the mechanisms regulating the stability and function of Treg cells have not been fully elucidated. Here we show SUMO-specific protease 3 (SENP3) is a pivotal regulator of Treg cells that functions by controlling the SUMOylation and nuclear localization of BACH2. Treg cell-specific deletion of Senp3 results in T cell activation, autoimmune symptoms and enhanced antitumor T cell responses. SENP3-mediated BACH2 deSUMOylation prevents the nuclear export of BACH2, thereby repressing the genes associated with CD4+ T effector cell differentiation and stabilizing Treg cell-specific gene signatures...
August 8, 2018: Nature Communications
Fei Huang, Li-Yang Gao, Jin-Huan Deng, Shao-Hua Chen, Kun-Zheng Cai
This study investigated the efficiency and mechanisms of Cd2+ removal by chicken-manure biochar produced at different temperatures. Adsorption kinetics, isotherms, thermodynamic, and desorption were examined, and the biochars before and after adsorption were analyzed by SEM-EDS, FTIR, Boehm titration, and XRD. Kinetics of adsorption were better described by pseudo-second-order kinetic model than pseudo-first-order kinetic and intraparticle diffusion model under different initial Cd2+ concentrations of 20, 50, and 100 mg L-1 ...
August 6, 2018: Environmental Science and Pollution Research International
Yan-Kun Jin, Xiao-He Li, Wang Wang, Jie Liu, Wei Zhang, Yin-Shan Fang, Zhi-Fei Zhang, Hua-Ping Dai, Wen Ning, Chen Wang
Background: Follistatin-like 1 (FSTL1) is a novel profibrogenic factor that induces pulmonary fibrosis (PF) through the transforming growth factor-beta 1 (TGF-β1)/Smad signaling. Little is known about its effects on PF through the non-Smad signaling, like the mitogen-activated protein kinase (MAPK) pathway. Therefore, this study aimed to investigate the role of FSTL1 in PF through the MAPK signaling pathway and its mechanisms in lung fibrogenesis. Methods: PF was induced in Fstl1+/- and wild-type (WT) C57BL/6 mice with bleomycin...
August 20, 2018: Chinese Medical Journal
Xiao Hui Zhang, Jin Da Wang, Hong Yan Jia, Jing Shang Zhang, Yang Li, Ying Xiong, Jing Li, Xiao Xia Li, Yao Huang, Gu Yu Zhu, Shi Song Rong, Michael Wormstone, Xiu Hua Wan
Purpose: To identify disease-causing gene mutations in 21 northern Chinese families with congenital cataracts. Methods: Medical record collection and ophthalmologic examinations were conducted for 21 families with congenital cataracts. A volume of 5 ml of peripheral blood was drawn from each participant for genomic DNA isolation. Thirty-four known candidate genes for congenital cataracts were analyzed in the probands of 21 families with targeted next-generation sequencing (NGS)...
2018: Molecular Vision
Jie-Liang Liang, Wen-Hua Zhou, Shao-Ming Gao, Wan-Peng Yu, Wen-Sheng Shu, Jin-Tian Li
Agriculture-based climate change mitigation may occur through enhancing the carbon sink or through reducing greenhouse gases (GHGs) emissions from agricultural residue treatment, as open burning of agricultural residues produces millions of tons of GHGs and air pollutants annually worldwide. Charring slashed biomass, termed as slash-and-char, has been considered as a promising alternative to open burning in dealing with agricultural residues such as rice straw. Previous studies, however, focused on relatively sophisticated slash-and-char systems, which could not be practiced easily by smallholder farmers in developing countries...
July 20, 2018: Environmental Pollution
Sheng-Hua Li, Jin-Pin Li, Lan Chen, Jing-Li Liu
Aberrant expression of miR-146a has been reported to be involved in the progression and metastasis of various types of human cancers; however, its potential role in human neuroblastoma is still poorly understood. The purpose of our study was to investigate the molecular mechanism and possible role of miR-146a in human neuroblastoma. In this study, targeted genes were predicted by bioinformatic analysis and confirmed by dual-Luciferase reporter assay. The expression level of miR-146a in the human neuroblastoma SK-N-SH cell line was detected by quantitative RT-PCR...
August 2018: Medical Hypotheses
Jin-Zhong Huang, Yi Ren, Yuan Xu, Tao Chen, Terry C Xia, Zhuo-Ri Li, Jian-Nong Zhao, Fei Hua, Shiying Sheng, Ying Xia
Parkinson's disease (PD) is a common degenerative neurological disease leading to a series of familial, medical, and social problems. Although it is known that the major characteristics of PD pathophysiology are the dysfunction of basal ganglia due to injury/loss of dopaminergic neurons in the substantia nigra pars compacta dopaminergic and exhaustion of corpus striatum dopamine, therapeutic modalities for PD are limited in clinical settings up to date. It is of utmost importance to better understand PD pathophysiology and explore new solutions for this serious neurodegenerative disorder...
August 3, 2018: CNS Neuroscience & Therapeutics
Shun-Jin Liu, Xiao-Yu Liu, Jing-Hui Li, Jing Guo, Fan Li, Yang Gui, Xiu-Hua Li, Li Yang, Chun-Yun Wu, Yun Yuan, Juan-Juan Li
Microglia activation and its mediated production of proinflammatory mediators play important roles in different neurodegenerative diseases; hence, modulation of microglia activation has been considered a potential therapeutic strategy to ameliorate neurodegeneration. This study was aimed to determine whether Gastrodin, a common herbal agent known to possess neuroprotective property, can attenuate production of proinflammatory mediators in activated microglia through the renin-angiotensin system (RAS) and Sirtuin3 (SIRT3)...
July 31, 2018: Neurochemistry International
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