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Alexander V Prokhorov, Georges Elias Khalil, Karen Sue Calabro, Tamara Costello Machado, Sophia Russell, Katarzyna W Czerniak, Gabrielle C Botello, Minxing Chen, Adriana Perez, Damon J Vidrine, Cheryl L Perry
BACKGROUND: Community-college students are at high risk for tobacco use. Because the use of mobile phone text messaging is nearly ubiquitous today, short message service (SMS) may be an effective strategy for tobacco risk communication in this population. Little is known, however, concerning the message structure significantly influencing perceived tobacco risk. OBJECTIVE: We aim to outline the rationale and design of Project Debunk, a randomized trial comparing the effects of different SMS text message structures...
October 15, 2018: JMIR Research Protocols
Sergio Barros-Gomes, Abdallah El Sabbagh, Mackram F Eleid, Sunil V Mankrad
Non-atherosclerotic myocardial infarction (MI) is an important but often misdiagnosed cause of acute MI. Furthermore, non-atherosclerotic MI with concomitant acute stroke and pulmonary embolism due to in-transit thrombus across a patent foramen ovale (PFO) is a rare but potentially fatal combination (1, 2, 3). Early detection of this clinical entity can facilitate delivery of targeted therapies and avoid poor outcome (1, 2). Here, we describe a 68-year-old female with hypertension, tobacco abuse and chronic obstructive pulmonary disease presenting with facial droop, right arm weakness and aphasia...
December 1, 2018: Echo Research and Practice
Anjuli D Wagner, Irene N Njuguna, Jillian Neary, Vincent O Omondi, Verlinda A Otieno, Joseph Babigumira, Elizabeth Maleche-Obimbo, Dalton C Wamalwa, Grace C John-Stewart, Jennifer A Slyker
INTRODUCTION: Index case testing (ICT) to identify HIV-infected children is efficient but has suboptimal uptake. Financial incentives (FI) have overcome financial barriers in other populations by offsetting direct and indirect costs. A pilot study found FI to be feasible for motivating paediatric ICT among HIV-infected female caregivers. This randomised trial will determine the effectiveness of FI to increase uptake of paediatric ICT. METHODS AND ANALYSIS: The Financial Incentives to Increase Uptake of Pediatric HIV Testing trial is a five-arm, unblinded, randomised controlled trial that determines whether FI increases timely uptake of paediatric ICT...
October 3, 2018: BMJ Open
Raymond Kelly, Aisling McMahon, Dominic Hegarty
BACKGROUND: The growth of interventional pain medicine in recent years has resulted in more procedures being carried out under fluoroscopic guidance. The proximity of the pain physician (PP) to ionization radiation (IR) potentially increases the risk of radiation exposure to the ocular region. A European directive has reduced the limits of occupational ocular dose 7.5-fold. OBJECTIVES: The objectives of this study are to quantify the typical IR exposure in the ocular region of PP and to compare it to recommended international guidelines...
September 2018: Pain Physician
Bria Moore, K Roland Womack, Giao Nguyen, Norah Foster, William Richardson, Terry Yoshizumi
Background: The aim of this study was to determine the amount of radiation exposure from intraoperative imaging during two-level and four-level lumbar fusions. Methods: Five imaging systems were studied: multidetector CT (MDCT) scanner (CT A); two mobile CT units (CT B and CT C); a C-arm (D); and fluoroscopy (E). Metal oxide semiconductor field effect transistor dosimeters measured doses at 25 organ locations using an anthropomorphic phantom. A fat-equivalent phantom was used to simulate an obese body mass index (BMI)...
July 2018: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
Colin A Espie, Richard Emsley, Simon D Kyle, Christopher Gordon, Christopher L Drake, A Niroshan Siriwardena, John Cape, Jason C Ong, Bryony Sheaves, Russell Foster, Daniel Freeman, Joan Costa-Font, Antonia Marsden, Annemarie I Luik
Importance: Digital cognitive behavioral therapy (dCBT) is a scalable and effective intervention for treating insomnia. Most people with insomnia, however, seek help because of the daytime consequences of poor sleep, which adversely affects quality of life. Objectives: To investigate the effect of dCBT for insomnia on functional health, psychological well-being, and sleep-related quality of life and to determine whether a reduction in insomnia symptoms was a mediating factor...
September 25, 2018: JAMA Psychiatry
Sonja Schibany, Luise A K Kleine Borgmann, Thomas C Rösch, Tobias Knust, Maximilian H Ulbrich, Peter L Graumann
Structural Maintenance of Chromosomes (SMC) proteins and their complex partners (ScpA and ScpB in many bacteria) are involved in chromosome compaction and segregation in all kinds of organisms. We employed single molecule tracking (SMT), tracking of chromosomal loci, and single molecule counting in Bacillus subtilis to show that in slow growing cells, ∼30 Smc dimers move throughout the chromosome in a constrained mode, while ∼60 ScpA and ScpB molecules travel together in a complex, but independently of the nucleoid...
September 6, 2018: Nucleic Acids Research
Melanie J Miller, Sabrina C Agarwal, Lucero Aristizabal, Carl Langebaek
OBJECTIVES: Daily activities involve biomechanical strains acting on skeletal structures. This study identifies differences in activity patterns between males and females, and between young, middle, and older aged individuals within an excavated Muisca skeletal sample from the Eastern Andes region of Northern South America. MATERIALS AND METHODS: The Tibanica archaeological site (AD 1000-1400) is located at 2600 masl on the Sabana de Bogotá, Colombia. Cross-sectional geometric analysis of femurs from 63 individuals and paired-humerii from 33 individuals was used to examine bone size (TA), strength (J) and diaphyseal shape (Imax /Imin , Ix /Iy )...
September 7, 2018: American Journal of Physical Anthropology
S Navarro-Ledesma, M Fernandez-Sanchez, A Luque-Suarez
OBJECTIVE: To determine the association between pectoralis minor length (PML) and the acromiohumeral distance (AHD) in the symptomatic (S) and the asymptomatic (A) shoulder of subjects with chronic shoulder pain, and in shoulder free of pain controls (C). Furthermore, to analyze the relationship between PML and shoulder pain-function and range of movement (ROM) free of pain. DESIGN: A cross sectional study. SETTING: Primary care centres. PARTICIPANTS: A sample of fifty-four participants with chronic shoulder pain in their dominant arm was recruited, as well as fifty-four participants with shoulder free of pain...
August 23, 2018: Physical Therapy in Sport
V S Malysheva, V V Gorelik, V N Vlasov
BACKGROUND: Strengthening the health of the young people and adolescents is a priority task for the health care system. The posture, as a habitual position of the body of a person standing at ease, is formed in the course of the child's physical development including the development of the static-dynamic functions. The problems of rehabilitation of the school-age children arising from the necessity to correct impaired posture, including scoliosis, are associated with their life activity and the socio-economic status...
2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Sergio Barros-Gomes, Abdullah El Sabbagh, Mackram F Eleid, Sunil V Mankad
Non-atherosclerotic myocardial infarction (MI) is an important but often misdiagnosed cause of acute MI. Furthermore, non-atherosclerotic MI with concomitant acute stroke and pulmonary embolism due to in-transit thrombus across a patent foramen ovale (PFO) is a rare but potentially fatal combination (1-3). Early detection of this clinical entity can facilitate delivery of targeted therapies and avoid poor outcome (1, 2). Here, we describe a 68-year-old female with hypertension, tobacco abuse, and chronic obstructive pulmonary disease presenting with facial droop, right arm weakness and aphasia...
August 11, 2018: Echo Research and Practice
Adrien Kaladji, Alexandre Villena, Remy Pascot, Florent Lalys, Anne Daoudal, Elodie Clochard, Antoine Lucas, Alain Cardon
INTRODUCTION: Fusion imaging is a technique that facilitates endovascular navigation but is only available in hybrid rooms. The goal of this study was to evaluate the feasibility of fusion imaging with a mobile C-arm in a conventional operating room through the use of an angio-navigation station. METHODS: From May 2016 to June 2017, the study included all patients who underwent an aortic stent graft procedure in a conventional operating room with a mobile flat-panel detector (Cios Alpha, Siemens) connected to an angio-navigation station (EndoNaut, Therenva)...
August 6, 2018: Annals of Vascular Surgery
Matthew C Shake, K Jason Crandall, Rilee P Mathews, Dustin G Falls, A Kathryn Dispennette
OBJECTIVE: A significant barrier to improving the health and well-being of older adults is that they often do not adhere to health-promoting programs. The present study examined whether Bingocize® , a game-centered mobile app that can combine bingo with healthy activities such as exercise and/or health topic education, could (1) engender high rates of adherence among sedentary community-dwelling older adults, and (2) potentially improve aspects of physical and cognitive performance. MATERIALS AND METHODS: Participants used the app for ∼1 hour, twice per week, for 10 weeks...
August 2018: Games for Health
Sandra C Fuchs, Erno Harzheim, Cirano Iochpe, Caroline N de David, Marcelo R Gonçalves, Guilhermo P Sesin, Cassio M Costa, Leila B Moreira, Flavio D Fuchs
BACKGROUND: Hypertension is a growing problem worldwide, markedly in low- and middle-income countries, where the rate of control slightly decreased. The overall prevalence of hypertension in Brazil is 28.7% among adult individuals and 68.9% in the population aged 60 years and older, and less than a third of patients have controlled blood pressure (BP). The use of technologies-mobile phones and the internet-to implement interventions to reduce blood pressure can minimize costs and diminish cardiovascular risk...
August 7, 2018: JMIR Research Protocols
Cassandra Wright, Paul M Dietze, Paul A Agius, Emmanuel Kuntsche, Michael Livingston, Oliver C Black, Robin Room, Margaret Hellard, Megan Sc Lim
BACKGROUND: Real-time ecological momentary interventions have shown promising effects in domains other than alcohol use; however, only few studies regarding ecological momentary interventions for alcohol use have been conducted thus far. The increasing popularity of smartphones offers new avenues for intervention and innovation in data collection. OBJECTIVE: We aimed to test the efficacy of an ecological momentary intervention, comprising mobile Web-based ecological momentary assessments (EMAs) and text messaging (short message service, SMS) brief interventions, delivered during drinking events using participants' mobile phones...
July 20, 2018: JMIR MHealth and UHealth
Kelechi R Okoroha, Jason E Meldau, Vincent A Lizzio, Fabien Meta, Jeffrey P Stephens, Vasilious Moutzouros, Eric C Makhni
BACKGROUND: The incidence of overuse injury to the elbow among baseball pitchers continues to rise, despite extensive efforts at pitch count regulations and emphasis on proper throwing mechanics. PURPOSE: To determine if the medial elbow experiences increased torque levels as a baseball pitcher fatigues through the course of a simulated game. STUDY DESIGN: Descriptive laboratory study. METHODS: High school and collegiate baseball pitchers were recruited for this simulated game study...
August 2018: American Journal of Sports Medicine
Peter H Richter, Florian Gebhard, Alexander Eickhoff, Konrad Schütze
The invention of flat-panel detectors led to a revolution in medical imaging. The major benefits of this technology are a higher image quality and dose reduction. Flat-panel detectors have proved to be superior to standard C-arms (= C-arm with radiograph source and image intensifier).Cone-beam computed tomography (cone-beam CT) is a 3D data set, which can be acquired with a flat-panel detector. The cone-shaped beam is used for 3D data generation. For cone-beam CT acquisition, the flat-panel detector rotates around the patient lying on the operating table...
May 2018: EFORT Open Reviews
Thu H M Nguyen, Patricia E Carreira, Francisco J Sanchez-Luque, Stephanie N Schauer, Allister C Fagg, Sandra R Richardson, Claire M Davies, J Samuel Jesuadian, Marie-Jeanne H C Kempen, Robin-Lee Troskie, Cini James, Elizabeth A Beaven, Tristan P Wallis, Jermaine I G Coward, Naven P Chetty, Alexander J Crandon, Deon J Venter, Jane E Armes, Lewis C Perrin, John D Hooper, Adam D Ewing, Kyle R Upton, Geoffrey J Faulkner
LINE-1 (L1) retrotransposons are a source of insertional mutagenesis in tumor cells. However, the clinical significance of L1 mobilization during tumorigenesis remains unclear. Here, we applied retrotransposon capture sequencing (RC-seq) to multiple single-cell clones isolated from five ovarian cancer cell lines and HeLa cells and detected endogenous L1 retrotransposition in vitro. We then applied RC-seq to ovarian tumor and matched blood samples from 19 patients and identified 88 tumor-specific L1 insertions...
June 26, 2018: Cell Reports
Rohan C Siriwardana, Sumudu K Kumarage, Bhagya M Gunathilake, Suchintha B Thilakarathne, Jeevani S Wijesinghe
BACKGROUND: Transverse abdominal plane block (TAP) is a new technique of regional block described to reduce postoperative pain in laparoscopic cholecystectomy (LC). Recent reports describe an easy technique to deliver local anesthetic agent under laparoscopic guidance. METHODS: This randomized control trial was designed to compare the effectiveness of additional laparoscopic-guided TAP block against the standard full thickness port site infiltration. 45 patients were randomized in to each arm after excluding emergency LC, conversions, ones with coagulopathy, pregnancy and allergy to local anesthetics...
June 25, 2018: Surgical Endoscopy
A C Berry
Tremendous advancements in syndromic surveillance strategies over the last two decades, and specifically from prior mass gatherings, have been incorporated into day-to-day healthcare analysis worldwide and have left a lasting indirect impact since their inception. Mass gatherings are a daily occurrence worldwide and provide a scenario ripe for public health aims and objectives utilising syndromic surveillance. Europe is less than a decade away from hosting a colossal worldwide gathering (2024 Summer Olympics) in likely a time when the global agreement is in flux...
June 22, 2018: Epidemiology and Infection
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