keyword
https://read.qxmd.com/read/38362442/negative-impact-of-gemtuzumab-ozogamicin-on-cd33-positive-early-t-cell-precursor-acute-lymphoblastic-leukemia-a-case-report
#21
Osamu Imataki, Haruyuki Fujita, Makiko Uemura
INTRODUCTION: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare subtype of T-cell leukemia that phenotypically expresses mature T-cell markers and immature myeloid markers such as CD33. Gemtuzumab ozogamicin (GO) is a novel agent for the CD33 molecular targeting antibody conjugated to the cytotoxic agent calicheamicin. GO is anticipated to be effective against ETP-ALL. In vivo studies promise antileukemic effects in cell lines; however, clinical reports to support this research are lacking...
2024: Case Reports in Oncology
https://read.qxmd.com/read/38328782/decoding-the-genetic-symphony-profiling-protein-coding-and-long-noncoding-rna-expression-in-t-acute-lymphoblastic-leukemia-for-clinical-insights
#22
JOURNAL ARTICLE
Deepak Verma, Shruti Kapoor, Sarita Kumari, Disha Sharma, Jay Singh, Mercilena Benjamin, Sameer Bakhshi, Rachna Seth, Baibaswata Nayak, Atul Sharma, Raja Pramanik, Jayanth Kumar Palanichamy, Sridhar Sivasubbu, Vinod Scaria, Mohit Arora, Rajive Kumar, Anita Chopra
T-acute lymphoblastic leukemia (T-ALL) is a heterogeneous malignancy characterized by the abnormal proliferation of immature T-cell precursors. Despite advances in immunophenotypic classification, understanding the molecular landscape and its impact on patient prognosis remains challenging. In this study, we conducted comprehensive RNA sequencing in a cohort of 35 patients with T-ALL to unravel the intricate transcriptomic profile. Subsequently, we validated the prognostic relevance of 23 targets, encompassing (i) protein-coding genes- BAALC , HHEX , MEF2C , FAT1 , LYL1 , LMO2 , LYN , and TAL1 ; (ii) epigenetic modifiers- DOT1L , EP300 , EML4 , RAG1 , EZH2 , and KDM6A ; and (iii) long noncoding RNAs (lncRNAs)- XIST , PCAT18 , PCAT14 , LINC00202 , LINC00461 , LINC00648 , ST20 , MEF2C-AS1 , and MALAT1 in an independent cohort of 99 patients with T-ALL...
February 2024: PNAS Nexus
https://read.qxmd.com/read/38325287/assessment-of-heavy-metals-accumulation-by-vegetables-irrigated-with-different-stages-of-textile-wastewater-for-evaluation-of-food-and-health-risk
#23
JOURNAL ARTICLE
Jahidul Hassan, Md Mijanur Rahman Rajib, Md Noor-E-Azam Khan, Shahjalal Khandaker, Md Zubayer, Kazi Raghib Ashab, Takahiro Kuba, Hadi M Marwani, Abdullah M Asiri, Md Munjur Hasan, Aminul Islam, Mohammed M Rahman, Md Rabiul Awual
Wastewater irrigation for vegetable cultivation is greatly concerned about the presence of toxic metals in irrigated soil and vegetables which causes possible threats to human health. This study aimed to ascertain the accumulation of heavy metals (HMs) in edible parts of vegetables irrigated with different stages of textile dyeing wastewater (TDW). Bio-concentration factor (BCF), Estimated daily intake (EDI), and target hazard quotient (THQ) were computed to estimate human health risks and speculate the hazard index (HI) of adults and children with the consumption of HMs contaminated vegetables at recommended doses...
February 6, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38296772/hemostatic-imbalance-induced-by-tamoxifen-in-estrogen-receptor-positive-breast-cancer-patients-an-observational-study
#24
JOURNAL ARTICLE
Marie Didembourg, Sara Reda, Johannes Oldenburg, Heiko Rühl, Jonathan Douxfils, Laure Morimont
BACKGROUND: Estrogen receptor (ER)-positive (ER+) breast cancer accounts for approximately 75% of all breast cancers. Tamoxifen, a selective estrogen receptor modulator, is the standard adjuvant treatment. Although better tolerated than aromatase inhibitors, tamoxifen increases the risk of venous thromboembolism (VTE) 1.4-fold. AIM: To assess the hemostatic imbalance induced by tamoxifen in adjuvant treatment of ER+ breast cancer. METHOD: Twenty-five patients in remission from ER+ breast cancer under tamoxifen were included...
January 31, 2024: International Journal of Laboratory Hematology
https://read.qxmd.com/read/38295552/development-and-feasibility-of-an-exercise-training-program-in-primary-care-for-patients-with-copd-experiencing-an-acute-exacerbation
#25
JOURNAL ARTICLE
Marieke Wuyts, Fien Hermans, Sofie Breuls, Stephanie Everaerts, Eric Derom, Wim Janssens, Heleen Demeyer, Thierry Troosters
BACKGROUND: Starting rehabilitation soon after an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is crucial to diminish the detrimental effects of this acute event on muscle function. However, uptake in outpatient pulmonary rehabilitation is low. OBJECTIVES: To design and test a feasible, acceptable and accessible exercise training program (ETP) in primary care for patients experiencing an AECOPD. DESIGN: (1) A literature review and qualitative study to develop an ETP and (2) A feasibility study of the ETP implemented in primary care...
October 5, 2023: Physiotherapy
https://read.qxmd.com/read/38289193/betz-cells-of-the-primary-motor-cortex
#26
REVIEW
Matthew Nolan, Connor Scott, Patrick R Hof, Olaf Ansorge
Betz cells, named in honor of Volodymyr Betz (1834-1894), who described them as "giant pyramids" in the primary motor cortex of primates and other mammalian species, are layer V extratelencephalic projection (ETP) neurons that directly innervate α-motoneurons of the brainstem and spinal cord. Despite their large volume and circumferential dendritic architecture, to date, no single molecular criterion has been established that unequivocally distinguishes adult Betz cells from other layer V ETP neurons...
January 2024: Journal of Comparative Neurology
https://read.qxmd.com/read/38269085/idh2-mutated-near-etp-all-with-aggressive-leukemia-cutis-and-brisk-response-to-venetoclax-and-decitabine
#27
Poorva Vaidya, Huan-You Wang, Michelle D Don, Brian R Hinds, James K Mangan
Near early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare hematologic malignancy, for which second line therapeutic options are limited. T-cell leukemias are also rarely associated with leukemia cutis, which is more often seen in leukemias of myeloid origin. We present the case of an adult male diagnosed with near ETP-ALL, with IDH2 and DNMT3A mutations, suggestive of a myeloid origin, and leukemia cutis. After the patient progressed on hyper-CVAD and nelarabine, we treated him with the BCL-2 inhibitor venetoclax and the hypomethylating agent decitabine...
2024: Leukemia Research Reports
https://read.qxmd.com/read/38267673/tbi-etoposide-and-cyclophosphamide-conditioning-for-intermediate-risk-relapsed-childhood-acute-lymphoblastic-leukemia
#28
JOURNAL ARTICLE
Hideaki Ueki, Chitose Ogawa, Hiroaki Goto, Masanori Nishi, Junko Yamanaka, Shinji Mochizuki, Takuro Nishikawa, Tadashi Kumamoto, Ritsuo Nishiuchi, Atsushi Kikuta, Shohei Yamamoto, Shunji Igarashi, Atsushi Sato, Toshinori Hori, Akiko M Saito, Tomoyuki Watanabe, Takao Deguchi, Atsushi Manabe, Keizo Horibe, Hidemi Toyoda
BACKGROUND: In children with intermediate-risk relapsed acute lymphoblastic leukemia (ALL), allogeneic hematopoietic stem cell transplantation (allo-HSCT) has markedly improved the outcome of patients with an unsatisfactory minimal residual disease (MRD) response. Total body irradiation (TBI), etoposide (ETP), and cyclophosphamide (CY) have been shown to be equivalent to or better than TBI + ETP for conditioning, so we hypothesized that even greater survival could be achieved due to recent advances in HSCT and supportive care...
January 25, 2024: International Journal of Hematology
https://read.qxmd.com/read/38266188/the-unique-fe-3-mo-3-n-structure-bestowed-efficient-fenton-like-performance-of-the-iron-based-catalysts-the-double-enhancement-of-radicals-and-non-radicals
#29
JOURNAL ARTICLE
Zhen Liu, Ruidian Su, Fei Xu, Xing Xu, Baoyu Gao, Qian Li
Iron-based catalysts have been widely used in Fenton-like water pollution control technology due to their high efficiency, but their practical applications have been limited by complex preparation conditions and strong blockage of Fe2+ /Fe3+ cycle during the reaction. In this study, a new iron-molybdenum bimetallic carbon-based catalyst is designed and synthesized using cellulose hydrogel for adsorption of Fe and Mo bimetals as a template, and the effective iron cycle in water treatment was realized. The integrated materials (Fe2...
January 24, 2024: Advanced Materials
https://read.qxmd.com/read/38241764/exercise-and-hypoxia-induced-hypercoagulability-is-counterbalanced-in-women-in-part-by-decreased-platelet-reactivity
#30
JOURNAL ARTICLE
M Ninivaggi, F Swieringa, H Middelveld, V Schmalschläger, M Roest, R de Laat-Kremers, B de Laat
Hypoxia plays an important role in several pathologies, e.g. chronic obstructive pulmonary disease and obstructive sleep apnea syndrome, and is linked to an increased thrombosis risk. Furthermore, oxygen deprivation is associated with hypercoagulability. In this study, we investigated the effect of gender and exercise on the coagulation potential under hypoxic conditions at high altitude by assessing thrombin generation (TG) and platelet activation. Hereto, ten healthy volunteers were included (50 % male, median age of 27...
January 12, 2024: Thrombosis Research
https://read.qxmd.com/read/38237861/altered-whole-blood-thrombin-generation-and-hyperresponsive-platelets-in-patients-with-pancreatic-cancer
#31
JOURNAL ARTICLE
Ruth Anne Laura Willems, Joke Konings, Dana Huskens, Harmen Middelveld, Nicol Pepels-Aarts, Lisa Verbeet, Phillip Gerrit de Groot, Johan Willem Marie Heemskerk, Hugo Ten Cate, Judith de Vos-Geelen, Bas de Laat, Mark Roest
BACKGROUND: Thromboembolic disease is a major complication in patients with pancreatic ductal adenocarcinoma (PDAC). Patients with PDAC often have altered blood cell counts, which are associated with venous thromboembolism (VTE) development. The high thrombotic risk in patients with PDAC may be partially caused by procoagulant blood cells. OBJECTIVES: The aim of this study was to compare blood cell-dependent coagulation between patients with PDAC (n = 18) and healthy controls matched for age and sex (n = 18)...
January 17, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38236135/chronic-exposure-to-parabens-promotes-non-alcoholic-fatty-liver-disease-in-association-with-the-changes-of-the-gut-microbiota-and-lipid-metabolism
#32
JOURNAL ARTICLE
Yilin Ren, Xinyi Shi, Jing Mu, Shenyin Liu, Xin Qian, Wenlong Pei, Shanhong Ni, Zhengduo Zhang, Lei Li, Zhan Zhang
Non-alcoholic fatty liver disease (NAFLD) has become a serious public health issue due to changing dietary patterns and composition. However, the relationship between NAFLD occurrence and food additives, such as preservatives, remains unknown. This study aimed to evaluate the toxicity of parabens, namely methylparaben (MeP) and ethylparaben (EtP), in relation to NAFLD occurrence in mice under different dietary conditions. Exposure to MeP and EtP exacerbated high-fat diet (HFD)-induced obesity, glucose intolerance, higher serum lipid concentrations, and fat accumulation by upregulating genes involved in lipid metabolism...
January 18, 2024: Food & Function
https://read.qxmd.com/read/38232552/an-integrated-transcriptome-microbiome-host-relationship-associated-with-paraben-toxicity-in-the-brackish-water-flea-diaphanosoma-celebensis
#33
JOURNAL ARTICLE
Euihyeon Lee, Kyun-Woo Lee, Min-Seok Kim, Junewoo Park, Yeun Park, Jae-Seong Lee, Hye-Min Kang
Parabens, a group of alkyl esters of p-hydroxybenzoic acid, have been found in aquatic systems in particular, leading to concerns about their potential impact on ecosystems. This study investigated the effects of three commonly used parabens, methylparaben (MeP), ethylparaben (EtP), and propylparaben (PrP), on the brackish water flea Diaphanosoma celebensis. The results showed that PrP had the most adverse impact on survival rates, followed by EtP and MeP, while MeP and EtP induced significant adverse effects on reproductive performance...
January 12, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38225824/diagnostic-and-therapeutic-advances-in-adults-with-acute-lymphoblastic-leukemia-in-the-era-of-gene-analysis-and-targeted-immunotherapy
#34
REVIEW
Jae-Ho Yoon, Seok Lee
Acute lymphoblastic leukemia (ALL) is one of the most rapidly changing hematological malignancies with advanced understanding of the genetic landscape, detection methods of minimal residual disease (MRD), and the development of immunotherapeutic agents with good clinical outcomes. The annual incidence of adult ALL in Korea is 300-350 patients per year. The WHO classification of ALL was revised in 2022 to reflect the molecular cytogenetic features and suggest new adverse- risk subgroups, such as Ph-like ALL and ETP-ALL...
January 2024: Korean Journal of Internal Medicine
https://read.qxmd.com/read/38220002/association-of-serum-bisphenols-parabens-and-triclosan-concentrations-with-sj%C3%A3-gren-syndrome-in-the-hangzhou-china-population
#35
JOURNAL ARTICLE
Kaizhen Liao, Yun Zhao, Jianli Qu, Wenfei Yu, Shetuan Hu, Shuhong Fang, Meirong Zhao, Hangbiao Jin
Exposure to endocrine-disrupting chemicals (EDCs) has been linked to various immune deficiency disorders, including autoimmune diseases like Sjögren Syndrome (SjS). However, the detrimental effects of exposure to EDCs, including bisphenols, parabens, and triclosan (TCS), on SjS have been inadequately documented. Thus, we conducted a cross-sectional study that included both healthy individuals (controls) and patients with SjS (cases). We assessed serum concentrations of bisphenol A (BPA), bisphenol S (BPS), methyl parabens (MeP), ethyl parabens (EtP), and TCS...
January 12, 2024: Science of the Total Environment
https://read.qxmd.com/read/38213979/selective-fluorescence-turn-on-detection-of-combination-cisplatin-etoposide-chemotherapy-based-on-n-cds-gsh-cuncs-nanoprobe
#36
JOURNAL ARTICLE
Khalid Alhazzani, Ahmed Z Alanazi, Aya M Mostafa, James Barker, Mohamed M El-Wekil, Al-Montaser Bellah H Ali
Cisplatin (CIS) and etoposide (ETP) combination therapy is highly effective for treating various cancers. However, the potential for pharmacokinetic interactions between these drugs necessitates selective sensing methods to quantitate both CIS and ETP levels in patient's plasma. This work develops a dual fluorescence probe strategy using glutathione-capped copper nanoclusters (GSH-CuNCs) and nitrogen-doped carbon dots (N-CDs) for the simultaneous analysis of CIS and ETP. The fluorescence signal of GSH-CuNCs at 615 nm increased linearly with CIS concentration while the N-CD emission at 480 nm remained unaffected...
January 10, 2024: RSC Advances
https://read.qxmd.com/read/38190529/fenton-like-activity-and-pathway-modulation-via-single-atom-sites-and-pollutants-comediates-the-electron-transfer-process
#37
JOURNAL ARTICLE
Jirui Guo, Yujie Wang, Yanan Shang, Kexin Yin, Qian Li, Baoyu Gao, Yanwei Li, Xiaoguang Duan, Xing Xu
The studies on the origin of versatile oxidation pathways toward targeted pollutants in the single-atom catalysts (SACs)/peroxymonosulfate (PMS) systems were always associated with the coordination structures rather than the perspective of pollutant characteristics, and the analysis of mechanism commonality is lacking. In this work, a variety of single-atom catalysts (M-SACs, M: Fe, Co, and Cu) were fabricated via a pyrolysis process using lignin as the complexation agent and substrate precursor. Sixteen kinds of commonly detected pollutants in various references were selected, and their ln k obs values in M-SACs/PMS systems correlated well ( R 2 = 0...
January 16, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38185243/effect-of-running-exercise-training-on-inflammatory-mediators-and-cytokines-expression-in-testicular-tissue-effect-of-exercise-intensity
#38
JOURNAL ARTICLE
Mozaffari Nazanin, Mazdak Razi, Javad Tolouei-Azar
The aim of this study is to investigate the impact of running exercise training protocols (ETPs) with varying intensities on inflammatory responses, with a specific focus on the interactions between inflammatory mediators, cytokines, and Leydig cell steroidogenic activity, as well as testosterone secretion. To this end, 24 Wistar rats were subdivided into sedentary control, low (LICT), moderate (MICT), and high (HICT) intensity continuous running ETP groups. After 8 weeks, the expression levels of Toll-like receptor-4 (TLR-4), nuclear factor-kappa-B (NF-KB), interleukin-6 (IL-6), interleukin-10 (IL-10), Tumor necrosis factor alpha (TNF-α), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and the testicular nitric oxide (NO) content were assessed and compared between groups...
January 5, 2024: Life Sciences
https://read.qxmd.com/read/38183556/novel-microsatellite-markers-suggest-significant-genetic-isolation-in-the-eastern-pacific-sponge-aplysina-gerardogreeni
#39
JOURNAL ARTICLE
Manuel Ricardo Salas-Castañeda, Nancy C Saavedra-Sotelo, José Antonio Cruz-Barraza, Celia Isabel Bisbal-Pardo, Axayácatl Rocha-Olivares
BACKGROUND: The Eastern Tropical Pacific (ETP) harbors a great diversity of Porifera. In particular, the Aplysina genus has acquired biotechnological and pharmacological importance. Nevertheless, the ecological aspects of their species and populations have been poorly studied. Aplysina gerardogreeni is the most conspicuous verongid sponge from the ETP, where it is usually found on rocky-coralline ecosystems. We evaluated the polymorphism levels of 18 microsatellites obtained from next-generation sequencing technologies...
January 6, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38171128/characterization-of-textile-effluent-treatment-plant-sludge-and-its-industrial-application-in-fired-clay-bricks-with-health-risk-assessment
#40
JOURNAL ARTICLE
Kaniz Fatema, Md Abu Nayem, Muhammad Shahriar Sanzid
The textile industry in Bangladesh faces environmental and health challenges due to the disposal of solid waste from Effluent Treatment Plants (ETPs). To address this issue, a study was conducted using soil from a brick industry near Dhaka, amending it with varying amounts of dry sludge to create clay bricks. The original soil had a loam texture and medium plasticity. The research found that adding 9 wt% of sludge resulted in Grade A commercial bricks with a compressive strength of 15.33 MPa and water absorption of 13...
January 2, 2024: Journal of Environmental Management
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