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Akhilesh Kumar Singh, Satbir Singh, Bipin Kumar Gupta
A strategy has been demonstrated to design a biluminescent security ink using Eu(TTA)3Phen (ETP) and fluorescein for protecting the currency and other essential documents viz. passport, bank cheque, certificates against counterfeiting. Biluminescent security ink exhibits strong red and green emission under 367 and 445 nm excitations, respectively. As it is quite challenging to prepare a material that possesses two prominent (green and red) and distinguishable colors upon excitation with two separate LEDs sources, emitting at different wavelengths, the biluminescent security ink would be hard to counterfeit as compared to the existing luminescent security ink that exhibits single color under UV light exposure...
December 3, 2018: ACS Applied Materials & Interfaces
Eric A Lewallen, Andre J van Wijnen, Carolina A Bonin, Nathan R Lovejoy
Flyingfishes are large enough to eat zooplankton, small enough to be consumed by top predators, and therefore form a central mid-trophic component of tropical epipelagic marine food webs. Characterizing patterns of flyingfish abundance, distribution, and habitat preference have important implications for understanding both localized and generalized functions of marine ecosystems. The eastern tropical Pacific Ocean (ETP) supports many flyingfish species and their predators, yet no studies to date have identified oceanographic factors that define flyingfish habitats or estimate species richness and diversity at broad taxonomic and geographic scales...
December 2018: Marine Biodiversity: a Journal of the Senckenberg Research Institute
Sk Abdul Amin, Nilanjan Adhikari, Shovanlal Gayen, Tarun Jha
The drug design and discovery of lipid modulators is very demanding as no new molecule has entered into the market in the last 35 years. Cholesteryl ester transfer protein (CETP) is a promising target as lipid modulators. Inhibition of the CETP enzyme reduces the risk of cardiovascular events. The first CETP inhibitor torcetrapib and related drug candidates failed in the clinical trial due to the off target effects leading to high toxicity. Thus, newer ETP inhibitors have now paramount importance to accelerate the drug discovery efforts in the field of cardiovascular disease (CVD)...
November 29, 2018: Journal of Biomolecular Structure & Dynamics
Anoop K Enjeti, Anita Ariyarajah, Angel D'Crus, Carlos Riveros, Michael Seldon, Lisa F Lincz
BACKGROUND AND AIMS: Myelodysplasia (MDS) is characterised by abnormal haematopoiesis and increased risk of bleeding. Microvesicles (MV) play a key role in coagulation and their impact in MDS is unknown. METHODS: Platelet free plasma from 35 red-cell transfusion-dependent MDS patients and 15 controls were analysed. Pro-coagulant function was assessed by the XaCT assay and by thrombin generation (ETP). Total MV were enumerated by nano-tracking analysis. MV subsets were quantified by flow cytometry after staining with specific antibodies for various endovascular cell types...
February 2019: Blood Cells, Molecules & Diseases
Lianxin Liu, Yuxing Ni
BACKGROUND: The aim was to evaluate the value of organ-specific weighted incidence antibiogram (OSWIA) percentages for bacterial susceptibilities of Gram-negative bacteria (GNB) collected from intra-abdominal infections (IAIs) during SMART 2010-2014. METHODS: We retrospectively calculated the OSWIA percentages that would have been adequately covered by 12 common antimicrobials based on the bacterial compositions found in the appendix, peritoneum, colon, liver, gall bladder and pancreas...
November 19, 2018: BMC Infectious Diseases
Ben Kayser, Jerry A Fereiro, Cunlan Guo, Sidney R Cohen, Mordechai Sheves, Israel Pecht, David Cahen
The incorporation of proteins as functional components in electronic junctions has received much interest recently due to their diverse bio-chemical and physical properties. However, information regarding the energies of the frontier orbitals involved in their electron transport (ETp) has remained elusive. Here we employ a new method to quantitatively determine the energy position of the molecular orbital, nearest to the Fermi level (EF) of the electrode, in the electron transfer protein Azurin. The importance of the Cu(ii) redox center of Azurin is demonstrated by measuring gate-controlled conductance switching which is absent if Azurin's copper ions are removed...
November 29, 2018: Nanoscale
Chuansha Wu, Wei Xia, Yuanyuan Li, Jiufeng Li, Bin Zhang, Tongzhang Zheng, Aifen Zhou, Hongzhi Zhao, Wenqian Huo, Jie Hu, Minmin Jiang, Chen Hu, Jiaqiang Liao, Xi Chen, Bing Xu, Shi Lu, Zongwei Cai, Shunqing Xu
Parabens are potential endocrine disruptors with short half-lives in the human body. To date, few epidemiological studies regarding repeated paraben measurements during pregnancy associated with fetal and childhood growth have been conducted. Within a Chinese prenatal cohort, 850 mother-infant pairs from whom a complete set of maternal urine samples were acquired during three trimesters were included, and the levels of five parabens were measured. We assessed the associations of both average and trimester-specific urinary paraben levels with weight and height z-scores at birth, 6 months, 1, and 2 years of age...
November 14, 2018: Environmental Science & Technology
Mario Buono, Marie-Laëtitia Thézénas, Alessandro Ceroni, Roman Fischer, Claus Nerlov
The ligand for the c-Kit receptor, KitL, exists as a membrane-associated (mKitL) and a soluble form (sKitL). KitL functions outside c-Kit activation have not been identified. We show that co-culture of c-Kit- and mKitL-expressing NIH3T3 cells results in signaling through mKitL: c-Kit-bound mKitL recruits calcium-modulating cyclophilin ligand (CAML) to selectively activate Akt, leading to CREB phosphorylation, mTOR pathway activation, and increased cell proliferation. Activation of mKitL in thymic vascular endothelial cells (VECs) induces mKitL- and Akt-dependent proliferation, and genetic ablation of mKitL in thymic VECs blocks their c-Kit responsiveness and proliferation during neonatal thymic expansion...
November 8, 2018: Nature Communications
Despina Fotiou, Theodoros N Sergentanis, Loula Papageorgiou, Kimon Stamatelopoulos, Maria Gavriatopoulou, Efstathios Kastritis, Theodora Psaltopoulou, Stella Salta, Patrick Van Dreden, Rabiatou Sangare, Annette K Larsen, Evangelos Terpos, Ismail Elalamy, Meletios A Dimopoulos, Grigoris T Gerotziafas
Venous thromboembolism (VTE) is a common complication in newly diagnosed symptomatic multiple myeloma (NDMM) patients. We explored cellular and plasma hypercoagulability in NDMM patients to identify relevant biomarkers that can be used in combination with clinical factors in the development of a risk assessment model (RAM) for VTE. Untreated patients (n = 144) with NDMM were prospectively enrolled, baseline biomarkers prior to anti-myeloma treatment and thromboprophylaxis initiation were obtained. These were compared against values in a group of healthy individuals with similar age and sex distribution...
November 7, 2018: Blood Cancer Journal
Kavita Garg, Sara Raichlin, Tatyana Bendikov, Israel Pecht, Mordechai Sheves, David Cahen
Different batches of Si wafers with nominally the same specifications were found to respond differently to identical chemical surface treatments aimed at re-growing Si oxide on them. We now found that the oxides produced on different batches of wafer, do differ electrically, thereby affecting solid-state electron transport (ETp) via protein films, assembled on them. These re-sults led to the another set of experiments, where we studied this phenomenon using two dis-tinct chemical methods to regrow oxides on the same batch of Si wafers...
October 30, 2018: ACS Applied Materials & Interfaces
Evgeniya Angelova, Charlene Audette, Yelena Kovtun, Naval Daver, Sa A Wang, Sherry Pierce, Sergej N Konoplev, Haitham Khogeer, Jeffrey L Jorgensen, Marina Konopleva, Patrick A Zweidler-McKay, L Jeffrey Medeiros, Hagop M Kantarjian, Elias J Jabbour, Joseph D Khoury
The potential of CD123-targeted therapies in acute lymphoblastic leukemia/lymphoma remains largely unexplored. We examined CD123 expression levels in a large cohort of acute lymphoblastic leukemia/lymphoma patients and assessed the in vitro impact of IMGN632, a conjugate of CD123-binding antibody with a novel DNA-alkylating payload. CD123 expression on leukemic blasts was surveyed in a large cohort of acute lymphoblastic leukemia/lymphoma patients using multicolor/multiparameter flow cytometry. The in vitro effect of IMGN632 was evaluated on B acute lymphoblastic leukemia/lymphoma cell lines and primary B acute lymphoblastic leukemia/lymphoma blasts...
October 25, 2018: Haematologica
Abdulrahman B O Mohamed, Hilde Kelchtermans, Joke Konings, Jamilla van Daal, Anas Al Marzouki, Steve Harakeh, Bas de Laat
BACKGROUND AND OBJECTIVES: The effect of oral contraceptive (OC) usage on coagulation has been studied worldwide. However, no such studies have been conducted in Saudi Arabia on Saudi women using OCs. The aim of this study was to investigate the effects of OC-induced changes of thrombin generation (TG) in the absence and presence of activated protein C (APC) or thrombomodulin (TM) in Saudi women. METHODS: A total of 115 adult women, 47 on oral contraception (OC users) and 68 controls (not using OCs) were recruited from the obstetrics-gynecology outpatient clinic in Saudi Arabia...
2018: PloS One
Yoonha Kim, Chang-Woo Seo, Abdul Latif Khan, Bong-Gyu Mun, Raheem Shahzad, Jeung-Woo Ko, Byung-Wook Yun, Soon-Ki Park, In-Jung Lee
BACKGROUND: Waterlogging (WL) is a key factor hindering soybean crop productivity worldwide. Plants utilize various hormones to avoid various stress conditions, including WL stress; however, the physiological mechanisms are still not fully understood. RESULTS: To identify physiological mechanisms during WL stress, different phytohormones, such as ethephon (ETP; donor source of ethylene), abscisic acid, gibberellins, indole-3-acetic acid, kinetin, jasmonic acid, and salicylic acid were exogenously applied to soybean plants...
October 22, 2018: BMC Plant Biology
Saartje Bloemen, Suzanne Zwaveling, Jonathan Douxfils, Mark Roest, Romy Kremers, François Mullier
INTRODUCTION: Calibrated automated thrombinography (CAT) is a sensitive method to assess coagulation. Dabigatran inhibits both free thrombin and the α2 macroglobulin (α2 M)-thrombin complex, which results in an erroneously increased peak and endogenous thrombin potential (ETP) without affecting lag time and time-to-peak. The aim of this study was to elucidate the artefacts in CAT when dabigatran is present. MATERIALS AND METHODS: Thrombin generation (TG) was measured in vitro by using CAT in the presence or absence of 6 μM idarucizumab in plasma spiked with dabigatran...
October 6, 2018: Thrombosis Research
Juliana Aparecida Cerqueira, Wilmer Alejandro Zamora Restan, Mayara Gonçalves Fonseca, Lucas Azevedo Catananti, Maria Luiza Mendes de Almeida, Walter Heinz Feringer Junior, Gener Tadeu Pereira, Aulus Cavalieri Carciofi, Guilherme de Camargo Ferraz
Few data exist on the physiological consequences of an incremental exercise test (IET) and training in dogs. Here we evaluated the effect of an endurance-training program (ETP) on the kinetics of the serum biomarkers: creatine kinase (CK), aspartate aminotransferase (AST), myoglobin, cardiac troponin I (cTnI), and creatine kinase isoenzyme MB (CK-MB). Eighteen Beagle dogs were assigned to three groups: sedentary (S), untrained (U), and trained (T). The dogs from the groups T and U underwent IET, and their lactate threshold (LT) was determined...
October 3, 2018: Research in Veterinary Science
Ping Wang, Xian'gui Peng, Xiaojuan Deng, Li Gao, Xi Zhang, Yimei Feng
RATIONALE: The diagnosis of hematological malignancies depends on laboratory analysis and often requires multiple experimental methods to judge, otherwise misdiagnosis is apt to happen. Lymph node biopsy immunohistochemistry (IHC) for T-lymphoblastic lymphoma (T-LBL) requires the establishment of antibody set screening. For identifying T-LBL and early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) by lymph node biopsy and IHC, WHO has not yet proposed a better IHC antibody combination...
October 2018: Medicine (Baltimore)
M A Khosa, Aman Ullah
In this review, we discussed the micro-level aspects of protein supported biosorption. The mechanism, surface chemistry in terms of energy interactions and electron transfer process (ETP) of peptide systems within protein are three important areas that provide mechanistic insight into protein supported biosorption. The functional groups in proteinous material like hydroxyl (-OH), carbonyl (>C=O), carboxyl (-COOH) and sulfhydryl (-SH) play a significant role in the biosorption of variety of pollutants such as metal ions, metalloids, and organic matters in wastewaters...
November 2018: Advances in Colloid and Interface Science
Brandon E Haines, Brandon M Nelson, Jessica M Grandner, Justin Kim, K N Houk, Mohammad Movassaghi, Djamaladdin G Musaev
The mechanism of permanganate-mediated dual C-H oxidation of complex diketopiperazines has been examined with density functional theory computations. The products of these oxidations are enabling intermediates in the synthesis of structurally diverse ETP natural products. We evaluated, for the first time, the impact of ion-pairing and aggregation states of the permanganate ion and counter-cations, such as bis(pyridine)-silver(I) (Ag+ ) and tetra- n-butylammonium (TBA+ ), on the C-H oxidation mechanism. The C-H abstraction occurs through an open shell singlet species, as noted previously, followed by O-rebound and a competing OH-rebound pathway...
October 17, 2018: Journal of the American Chemical Society
Subhasis Barik, Alexis N Cattin-Roy, Mindy M Miller, Tobechukwu K Ukah, Habib Zaghouani
Recently we reported that IL-4 and IL-13 signaling in murine early thymic progenitors (ETPs) expressing the heteroreceptor (HR) comprising IL-4 receptor α (IL-4Rα) and IL-13 receptor α 1 (IL-13Rα1) activate STAT6 and inhibit ETP maturation potential toward T cells. In this study, we asked whether IL-4 and IL-13 signaling through the HR mobilizes other STAT molecules to shape ETP fate decision. The findings indicate that HR+ ETPs undergoing cytokine signaling display increased STAT1, but not STAT3, phosphorylation in addition to STAT6 activation...
November 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
M Palova, L Slavik, A Hlusi, T Szotkowski, J Ulehlova, M Divoka, J Navratilova, T Papajik
BACKGROUND: Primary myelofibrosis (PMF) is a chronic clonal myeloid disorder. Together with essential thrombocythemia (ET) and polycythemia vera (PV), it belongs to a group of Philadelphia chromosome-negative myeloproliferative neoplasms. Thrombotic events are serious complications negatively influencing the quality and length of these patients' lives. The confirmed risk factors for venous thromboembolism are age over 60 years, a positive history of thromboembolism, presence of common cardiovascular risks, JAK2 V617F mutation and, according to some authors, leukocytosis...
September 1, 2018: Clinical Laboratory
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