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https://www.readbyqxmd.com/read/29790623/the-analysis-of-microbial-spectrum-and-antibiotic-resistance-of-uropathogens-isolated-from-patients-with-urinary-stones
#1
Dong Chen, Yuyan Zhang, Jian Huang, Xiongfa Liang, Tao Zeng, Chuangxin Lan, Xiaolu Duan, Zhijian Zhao, Guohua Zeng, Hans-Göran Tiselius, Xiaogang Lu, Wenqi Wu
PURPOSE: The characteristics and resistance patterns of urine bacteriology in patients with urinary tract stones have not been extensively studied. This study aims to investigate the microbial spectrum and antibiotic resistance of uropathogens isolated from urinary tract infections in patients with urinary stones and provide a basis for appropriate antimicrobial treatments. METHODS: The results of positive bladder midstream urine cultures and their antimicrobial susceptibility were retrospectively analysed from hospitalised patients with diagnosis of urinary calculi and urinary tract infections between January 2010 and December 2015...
May 23, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29788988/prevalence-and-antimicrobial-susceptibility-patterns-of-extended-spectrum-beta-lactamase-producing-entrobacteriaceae-in-the-university-of-gondar-referral-hospital-environments-northwest-ethiopia
#2
Tigist Engda, Feleke Moges, Aschalew Gelaw, Setegn Eshete, Feleke Mekonnen
OBJECTIVE: This study aimed at assessing the magnitude, distribution, and the antimicrobial susceptibility of the extended spectrum beta-lactamase producing Entrobacteriaceae in the University of Gondar Referral Hospital environments. RESULTS: Out of a total of 384 samples, 14.8% were ESBL producing Entrobacteriaceae, where 42.10% Klebsiella pneumoniae, 35.09% Escherchia coli and 7.01% Proteus mirabilis were the predominant isolates. Most ESBL producing isolates, that is, 24...
May 22, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29788138/gram-negative-bacilli-are-a-major-cause-of-secondary-pneumonia-in-patients-with-pulmonary-tuberculosis-evidence-from-a-cross-sectional-study-in-a-tertiary-hospital-in-nigeria
#3
Garba Iliyasu, Aminu B Mohammad, Ahmad M Yakasai, Farouq M Dayyab, Joan Oduh, Abdulrazaq G Habib
Background: This study was aimed at describing the profile of bacterial aetiology of secondary pneumonia in pulmonary tuberculosis (PTB) patients. Methods: A 22-month analysis of patients with PTB and secondary bacterial pneumonia was conducted. Data on isolates recovered and the antimicrobial susceptibility profile were recorded. Results: Of the 141 patients, there were 79 (56%) males and the mean age was 35.98±15.93. Gram-negative bacilli were isolated with equal frequency as Streptococcus pneumoniae (63 [44...
May 19, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29774893/prevalence-and-antimicrobial-sensitivity-pattern-of-urinary-tract-infection-among-children-with-cerebral-palsy-moshi-tanzania
#4
Amon Ryakitimbo, Rune Philemon, Festo Mazuguni, Levina Msuya
Background: Urinary tract infection (UTI) in children with cerebral palsy (CP) is a challenging yet common clinical condition. Children with CP bare the greatest risk of contracting UTI because of their difficulties in neuromotor control which lead to delay of bladder control, causing incomplete bladder emptying and urine retention. Method: This was an analytical cross-sectional study that was conducted from September 2016 to March 2017 at Comprehensive Community Based Rehabilitation in Tanzania - Moshi and Kilimanjaro Christian Medical Centre Neurological Pediatrics Outpatient Clinic...
2018: Pediatric Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29772494/effects-of-ceftriaxone-induced-intestinal-dysbacteriosis-on-regulatory-t-cells-validated-by-anaphylactic-mice
#5
Xia Luo, Zengfeng Pan, Shuang Luo, Qi Liu, Shaowei Huang, Guanghua Yang, Feifei Nong, Yajun Fu, Xiangliang Deng, Lian Zhou
Both probiotics and pathogens in the human gut express pathogen-associated molecular patterns (PAMPs) and die with the release of endotoxin and bacterial DNA, which can stimulate our immune system and cause immune reaction. However, it's interesting and fascinating to address why the normal intestinal flora will not generate immunological rejection like the pathogen does. By investigating the changes in cells and molecules relevant to immune tolerance in mice with ceftriaxone-induced dysbacteriosis, our study discovered that both the Evenness indexes and Shannon Wiener index of intestinal flora showed a decrease in dysbacteriosis mice...
May 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29769008/biochemical-and-haematological-predictors-of-reduced-neutrophil-granulocyte-count-associated-with-intravenous-ceftriaxone-treatment
#6
Basant Puri, Anne Derham, Jean Monro
Background Intravenous treatment with ceftriaxone, a commonly used third-generation cephalosporin, is associated with a risk of the potentially fatal side-effect of neutropenia. Objective The first systematic study to determine whether six to 12 days' intravenous ceftriaxone treatment is associated with a reduction in the neutrophil count and the extent to which biochemical and/or haematological parameters routinely measured at baseline predict such a fall. Method Baseline and follow-up haematological and biochemical blood indices were measured in 86 patients (mean age 39...
May 16, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29764520/investigation-of-a-typhoid-fever-epidemic-in-moyale-sub-county-kenya-2014-2015
#7
Dahabo Adi Galgallo, Zeinab Gura Roka, Waqo G Boru, Khalumi Abill, James Ransom
AIM: Typhoid fever is a vaccine-preventable bacterial disease that causes significant morbidity and mortality throughout Africa. This paper describes an upsurge of typhoid fever cases in Moyale Sub-County (MSC), Kenya, 2014-2015. METHODS: We conducted active hospital and health facility surveillance and laboratory and antimicrobial sensitivity testing for all patients presenting with headache, fever, stomach pains, diarrhea, or constipation at five MSC health facilities between December 2014 and January 2015...
May 15, 2018: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29762885/influence-of-chemical-and-physical-conditions-in-selection-of-gluconacetobacter-hansenii-atcc-23769-strains-with-high-capacity-to-production-bacterial-cellulose-for-application-as-sustained-antimicrobial-drug-release-supports
#8
Silmara Cristina Lazarini, Caroline Yamada, Hernane da Silva Barud, Eliane Trovatti, Pedro Paulo Corbi, Wilton Rogério Lustri
AIMS: Obtain varieties of Gluconacetobacter hansenii from original strain ATCC 23729 with greater efficiency to produce bacterial cellulose (BC) membrane with better dry mass yield for application as support of sustained antimicrobials drug release. METHODS AND RESULTS: Application of different chemical and physical conditions (pH, temperature and UV light exposure) to obtain different G. hansenii varieties with high capacity to produce BC membranes. Characterization of the G...
May 15, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29760145/-in-vitro-activity-of-imipenem-relebactam-and-ceftolozane-tazobactam-against-resistant-gram-negative-bacilli
#9
Suzannah M Schmidt-Malan, Avisya J Mishra, Ammara Mushtaq, Cassandra L Brinkman, Robin Patel
Understanding which antimicrobial agents are likely to be active against Gram-negative bacilli can guide selection of antimicrobials for empiric therapy as mechanistic-based (i.e., molecular) rapid diagnostics are adopted. Here, we determined the MICs of the novel β-lactam/β-lactamase inhibitor combination, imipenem-relebactam, along with ceftolozane-tazobactam, imipenem, ertapenem, meropenem, ceftriaxone, and cefepime, against 283 multidrug resistant isolates of Gram-negative bacilli. For isolates harboring bla KPC (n=111), the addition of relebactam to imipenem lowered the MIC50 /MIC90 from 16/>128 μg/ml for imipenem alone to 0...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29759235/rapid-microbiological-methods-rmms-for-evaluating-the-activity-of-cephalosporin-antibiotics-employing-triphenyltetrazolium-chloride
#10
Alessandro Morais Saviano, Felipe Rebello Lourenço
Agar diffusion method has been used to evaluate antimicrobial activity since the discovery of penicillin. Nevertheless, little progress has occurred in reducing the time required to determine growth inhibition zones. The aim of this work was to develop, optimize and validate rapid microbiological methods (RMMs) for cephalosporin antibiotics using triphenyltetrazolium chloride (TTC) to reduce the incubation time of the assays. Through a factorial design in which the inoculum suspension, incubation time, and percentage of the TTC solution were varied, it was possible to validate the RMMs for cefazolin, cefuroxime, ceftriaxone, and cefepime...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29758367/clinical-and-neurosurgical-management-of-cranial-machete-injuries-the-experience-of-a-tertiary-referral-center-in-nicaragua
#11
Luis Zapata, Ernest J Wright, Peter Nakaji
BACKGROUND: The neurosurgical literature rarely describes managing open head injuries caused by machetes, although this is a common head injury in developing countries. We present our experience managing cranial machete injuries in Nicaragua over a 5-year period. METHODS: A retrospective chart review identified patients admitted to a neurosurgery service for cranial machete injury. RESULTS: Among 51 patients studied, the majority (n=42, 82%) presented with mild neurological deficits (Glasgow Coma Scale score ≥14)...
May 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29757696/a-refugee-patient-with-meningococcal-meningitis-type-b
#12
Aslinur Ozkaya-Parlakay, Saliha Kanik-Yuksek, Belgin Gulhan, Hasan Tezer, Filiz Altay, Nuriye Unal-Sahin
Neisseria meningitidis infection constitutes still a major health problem with significant morbidity and mortality. In this report a 2 year old refugee Turkoman boy admitting with fever and vomitting diagnosed as meningococcal meningitis type B who was cured with intravenous ceftriaxone therapy was presented to emphasize importance of implementing new strategies for health care of refugees.
May 14, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29755322/microglial-activation-after-systemic-stimulation-with-lipopolysaccharide-and-escherichia-coli
#13
Inge C M Hoogland, Dunja Westhoff, Joo-Yeon Engelen-Lee, Jeroen Melief, Mercedes Valls Serón, Judith H M P Houben-Weerts, Inge Huitinga, David J van Westerloo, Tom van der Poll, Willem A van Gool, Diederik van de Beek
Background: Microglial activation after systemic infection has been suggested to mediate sepsis-associated delirium. A systematic review of animal studies suggested distinct differences between microglial activation after systemic challenge with live bacteria and lipopolysaccharide (LPS). Here, we describe a mouse model of microglial activation after systemic challenge with live Escherichia coli ( E. coli ) and compare results with systemic challenge with LPS. Methods: Sixty mice were intraperitoneally injected with E...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29752649/risk-factors-for-pneumonia-due-to-beta-lactam-susceptible-and-beta-lactam-resistant-pseudomonas-aeruginosa-a-case-case-control-study
#14
Mohammed J Al-Jaghbeer, Julie Ann Justo, William Owens, Joseph Kohn, P Brandon Bookstaver, Jennifer Hucks, Majdi N Al-Hasan
PURPOSE: This case-case-control study aims to identify clinical predictors for pneumonia due to Pseudomonas aeruginosa (PA) which is (1) susceptible to all routinely tested antipseudomonal beta-lactams (APBL-S) and (2) resistant to at least one antipseudomonal beta-lactam (APBL-R). METHODS: Hospitalized adults with acute bacterial pneumonia at Palmetto Health hospitals in Columbia, SC, USA from January 1, 2012 to April 15, 2014 were identified. Multivariate logistic regression was used to determine risk factors for pneumonia due to APBL-S PA and APBL-R PA...
May 11, 2018: Infection
https://www.readbyqxmd.com/read/29751417/occurrence-and-characteristics-of-extended-spectrum-%C3%AE-lactamase-and-carbapenemase-producing-bacteria-from-hospital-effluents-in-singapore
#15
Laurence Haller, Hongjie Chen, Charmaine Ng, Thai Hoang Le, Tse Hsien Koh, Timothy Barkham, Mark Sobsey, Karina Yew-Hoong Gin
One of the most important resistance mechanisms in Gram-negative bacteria today is the production of enzymes causing resistance to cephalosporin and carbapenem antibiotics. The spread of extended-spectrum β-lactamases (ESBL)- and carbapenemase- producing Gram-negative bacteria is an emerging global public health problem. The aim of the present study was to (i) assess the prevalence of carbapenem-resistant bacteria (CRB) and ESBL-producing strains in sewage effluents from two major hospitals in Singapore, (ii) characterize the isolated strains and (iii) identify some of the ESBL and carbapenemase genes responsible for the resistance...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29750894/ceftriaxone-treatment-of-complicated-urinary-tract-infections-as-a-risk-factor-for-enterococcal-re-infection-and-prolonged-hospitalization-a-6-year-retrospective-study
#16
Kristian Karlović, Jadranka Nikolić, Jurica Arapović
A frequent complication during hospital stay of patients with urinary tract infections (UTIs) is a re-infection of the urinary tract after the initial improvement. In this study, we investigated the impact of two empirical antibiotic therapies on the outcomes of complicated bacterial UTIs. We retrospectively evaluated 325 adult patients hospitalized during 6 years period with a diagnosis of complicated bacterial UTIs. The patients were classified into two groups according to the antibiotic therapy: ceftriaxone- and co-amoxiclav+gentamicin-treated group...
May 5, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29747999/streptococcus-pneumoniae-prevalence-in-nasopharyngeal-carriers-of-more-than-50-years-old-in-a-mexican-rural-community
#17
Luz Elena Espinosa de Los Monteros-Pérez, Rodolfo Norberto Jiménez-Juárez, Demóstenes Gómez-Barreto, Carlos Francisco Navas-Villar
INTRODUCTION: Streptococcus pneumoniae (Sp) is the main cause of community-acquired pneumonia in the elderly, hence the importance to establish the prevalence of nasopharyngeal colonization by different Sp serotypes in adults. METHODS: from December 2009 to June 2010, nasopharyngeal cultures were taken from adults living in rural communities in Mexico for the isolation and serotyping of Sp by the Quellung reaction. Penicillin and ceftriaxone susceptibility tests were performed by the microdilution method...
May 7, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29745864/modulation-of-the-expression-of-genes-related-to-the-system-of-amyloid-beta-metabolism-in-the-brain-as-a-novel-mechanism-of-ceftriaxone-neuroprotective-properties
#18
Maria A Tikhonova, Tamara G Amstislavskaya, Victor M Belichenko, Larisa A Fedoseeva, Sergey P Kovalenko, Ekaterina E Pisareva, Alla S Avdeeva, Nataliya G Kolosova, Nikolai D Belyaev, Lyubomir I Aftanas
BACKGROUND: The dominant hypothesis about the pathogenesis of Alzheimer's disease (AD) is the "amyloid cascade" concept and modulating the expression of proteins involved in the metabolism of amyloid-beta (Aβ) is proposed as an effective strategy for the prevention and therapy of AD. Recently, we found that an antibiotic ceftriaxone (CEF), which possesses neuroprotective activity, reduced cognitive deficits and neurodegenerative changes in OXYS rats, a model of sporadic AD...
April 19, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29743001/emergence-of-quinolone-resistant-shigella-flexneri-in-italy-march-2017
#19
Marta Zatta, Stefano Di Bella, Marina Busetti, Valeria Michelacci, Slawomir Owczarek, Ida Luzzi, Roberto Luzzati
In March 2017, a 45-year-old Italian man who has sex with men was admitted to the Infectious Diseases Department of Trieste Hospital (northeast Italy), because of fever, abdominal pain and dysentery. The patient had neither foreign travel history nor sexual contact with non-Italian partners. Stool cultures grew multidrug-resistant Shigella flexneri (resistant to ampicillin, chloramphenicol, streptomycin, tetracycline, trimethoprim, amoxicillin/clavulanic acid and ciprofloxacin) and whole genome sequencing detailed the resistance features...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29741928/comparative-study-on-antibiotic-resistance-and-dna-profiles-of-salmonella-enterica-serovar-typhimurium-isolated-from-humans-retail-foods-and-the-environment-in-shanghai-china
#20
Zengfeng Zhang, Chenyang Cao, Bin Liu, Xuebin Xu, Yanfei Yan, Shenghui Cui, Sheng Chen, Jianghong Meng, Baowei Yang
We characterized antibiotic resistance profiles, antibiotic resistance-associated genes, and pulsed-field gel electrophoresis (PFGE) patterns of 145 Salmonella enterica serotype Typhimurium isolates from human infections and retail foods that were possibly responsible for salmonellosis outbreaks from 2008 to 2012 in Shanghai, China. Resistance to at least three antibiotics was found in 66.7% of chicken isolates, 76.5% of duck isolates, 77.8% of pork isolates, and 80.5% of human isolates. Seven antibiotic resistance phenotypes were detected in chicken isolates, 16 in pork isolates, 17 in duck isolates, and 50 in human isolates...
May 9, 2018: Foodborne Pathogens and Disease
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