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https://www.readbyqxmd.com/read/28221925/genetic-diversity-and-antibiotic-resistance-of-escherichia-coli-isolates-from-different-leafy-green-production-systems
#1
Mosimanegape Jongman, Lise Korsten
Foodborne disease outbreaks linked to contaminated irrigation water and fresh produce are a public health concern. The presence of Escherichia coli isolates from irrigation water and leafy green vegetables in different food production systems (large commercial farms, small-scale farms, and homestead gardens) was investigated. The prevalence of antibiotic resistance and virulence in these isolates was further assessed, and links between water source and irrigated crops were identified using antimicrobial and genotypic analyses...
November 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28220870/long-term-use-of-ceftriaxone-sodium-induced-changes-in-gut-microbiota-and-immune-system
#2
Yanjie Guo, Xuefei Yang, Yane Qi, Shu Wen, Yinhui Liu, Shaoying Tang, Rongsheng Huang, Li Tang
Antibiotic administration, while facilitating clearance of targeted infections, also perturbs commensal microbial communities. Previous studies have all focused on the effects of short term use of antibiotics. Here, we focus on the effects of long term use of antibiotic on gut microbiota and immunity. BALB/c mice received saline or different doses of ceftriaxone sodium (100, 200 and 400 mg/mL) via daily gavage for 150 days. Alterations of fecal microbiota, small intestine histopathology, body weight, spleen index, serum IgG, mucus SIgA, IFN-γ/IL-4 ratio, CD4/CD8 ratio and CD4(+)CD25(+) cells were evaluated...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220735/sustained-reduction-in-antibiotic-consumption-in-a-south-african-public-sector-hospital-four-year-outcomes-from-the-groote-schuur-hospital-antibiotic-stewardship-program
#3
T H Boyles, V Naicker, N Rawoot, P J Raubenheimer, B Eick, M Mendelson
BACKGROUND: Overuse of antibiotics has driven global bacterial resistance to the extent that we have entered a post-antibiotic era, where infections that were once easily treatable are now becoming untreatable. Efforts to control consumption have focused on antibiotic stewardship programmes (ASPs), aimed at optimising use. OBJECTIVE: To report antibiotic consumption and cost over 4 years from a public hospital ASP in South Africa (SA). METHODS: A comprehensive ASP comprising online education, a dedicated antibiotic prescription chart and weekly dedicated ward rounds was introduced at Groote Schuur Hospital, Cape Town, in 2012...
January 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28220707/first-description-of-a-rifampicin-resistant-neisseria-meningitidis-serogroup-y-strain-causing-recurrent-invasive-meningococcal-disease-in-hungary
#4
Ákos Tóth, Brigitta Berta, Tamás Tirczka, Csilla Jekkel, Anita Ábrahám, Zoltán Prohászka, Zsófia Bognár, Tímea Erdősi
A Hungarian soldier previously immunized against Neisseria meningitidis by quadrivalent polysaccharide vaccine was twice infected with meningococci within six weeks. The patient was treated with ceftriaxone during both episodes and he successfully recovered. His close contacts received rifampicin prophylaxis. An investigation was performed to characterize the genetic background of the pathogens to ascertain if the recurrent invasive meningococcal disease was caused by the same strain and to find out the reason for reinfection...
February 21, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28217763/impact-of-tigecycline-versus-other-antibiotics-on-the-fecal-metabolome-and-on-colonization-resistance-to-clostridium-difficile-in-mice
#5
Robin L P Jump, David Kraft, Kelly Hurless, Alex Polinkovsky, Curtis J Donskey
BACKGROUND: The glycylcycline antibiotic tigecycline may have a relatively low propensity to promote Clostridium difficile infection in part because it causes less disruption of the indigenous intestinal microbiota than other broad-spectrum antibiotics. We used a mouse model to compare the effects of tigecycline versus other commonly used antibiotics on colonization resistance to C. difficile and on the metabolic functions of the intestinal microbiota. METHODS: To assess in vivo colonization resistance to C...
January 18, 2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28213022/prevalence-genetic-diversity-and-antimicrobial-resistance-of-listeria-monocytogenes-isolated-from-fresh-and-smoked-fish-in-poland
#6
Kinga Wieczorek, Jacek Osek
A total of 57 out of 301 (18.9%) fresh and smoked fish samples in Poland were positive for Listeria monocytotgenes. The bacteria were most frequently identified in fresh and smoked salmon (32.0% and 33.8% respectively) as well as in fresh cod (31.8%). Only three samples of smoked salmon were contaminated with the bacteria above 100 CFU/g. Four molecular serogroups were identified and the most prevalent, 1/2a-3a (40 isolates; 70.2%), was present in samples from both marine (33 strains; 71.7%) and freshwater fish (7 isolates; 63...
June 2017: Food Microbiology
https://www.readbyqxmd.com/read/28210887/drug-resistant-neisseria-gonorrhoeae-latest-developments
#7
REVIEW
B Suay-García, M T Pérez-Gracia
Gonorrhea is the second most frequently reported notifiable disease in the United States and is becoming increasingly common in Europe. The purpose of this review was to assess the current state of drug-resistant Neisseria gonorrhoeae in order to evaluate future prospects for its treatment. An exhaustive literature search was conducted to include the latest research regarding drug resistance and treatment guidelines for gonorrhea. Gonococci have acquired all known resistance mechanisms to all antimicrobials used for treatment...
February 16, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28209468/characteristics-of-nontyphoidal-salmonella-gastroenteritis-in-taiwanese-children-a-9-year-period-retrospective-medical-record-review
#8
Yeh-Ting Hung, Chorng-Jang Lay, Chun-Lung Wang, Malcolm Koo
Nontyphoidal Salmonella is among the most common causes of acute pediatric gastroenteritis in Taiwan. It is important to study antibiotic resistance patterns in nontyphoidal Salmonella isolated from children. Therefore, the objective of this study was to investigate the prevalence of serogroups and susceptibility to antimicrobial nontyphoidal Salmonella isolated from Taiwanese children with gastroenteritis. A retrospective review of the medical records of patients aged under 18 years with a diagnosis of acute gastroenteritis at a regional hospital located in southern Taiwan from August 2000 to August 2009 was conducted...
February 13, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28208889/management-of-pneumonia-and-blood-stream-infections-with-new-antibiotic-adjuvant-entity-ceftriaxone-sulbactam-disodium-edetate-a-novel-way-to-spare-carbapenems
#9
Mohammad Shameem, Mohammad Amin Mir
INTRODUCTION: Nosocomial infections have been considered as a major health problem causing incremental morbidity, mortality and costs of therapy. AIM: This retrospective study was initiated with aim to analyse the comparative efficacy of a novel Antibiotic Adjuvant Entity (AAE), a combination of ceftriaxone + sulbactam + disodium edetate and meropenem in combination with colistin, for the management of Multi Drug Resistant (MDR) nosocomial Gram-negative bacterial infections...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28199151/antimicrobial-resistance-percentages-of-salmonella-and-shigella-in-seafood-imported-to-jordan-higher-percentages-and-more-diverse-profiles-in-shigella
#10
Mohammad M Obaidat, Alaa E Bani Salman
This study determined the prevalence and antimicrobial resistance of human-specific ( Shigella spp.) and zoonotic ( Salmonella enterica ) foodborne pathogens in internationally traded seafood. Sixty-four Salmonella and 61 Shigella isolates were obtained from 330 imported fresh fish samples from Egypt, Yemen, and India. The pathogens were isolated on selective media, confirmed by PCR, and tested for antimicrobial resistance. Approximately 79 and 98% of the Salmonella and Shigella isolates, respectively, exhibited resistance to at least one antimicrobial, and 8 and 49% exhibited multidrug resistance (resistance to three or more antimicrobial classes)...
February 15, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28196977/synergistic-effects-of-vancomycin-and-%C3%AE-lactams-against-vancomycin-highly-resistant-staphylococcus-aureus
#11
Fumiaki Tabuchi, Yasuhiko Matsumoto, Masaki Ishii, Keita Tatsuno, Mitsuhiro Okazaki, Tomoaki Sato, Kyoji Moriya, Kazuhisa Sekimizu
We previously reported isolating vancomycin (VAN) highly resistant Staphylococcus aureus (VRSA) strains from clinical methicillin-resistant S. aureus strains by repeating steps of in vitro mutagenesis and VAN selection. Here we describe that the in vitro susceptibility of these VRSA strains to VAN was markedly increased by combined treatment with β-lactams such as ceftriaxone and oxacillin. Furthermore, in an in vivo silkworm infection model with VRSA, a combination of VAN and ceftriaxone exhibited therapeutic effects, whereas a combination of VAN and oxacillin did not...
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28191374/klebsiella-pneumoniae-liver-abscess-a-case-report-and-review-of-literature
#12
Faisal Kamal, George Williams, Hina Akbar, Muhammad Ali Khan, Dipen Kadaria
Klebsiella pneumoniae (K.pneumoniae) is a known cause of pyogenic liver abscess (PLA) in the absence of hepatobiliary disease. In settings of hepatic infection, it has also been known to cause disseminated infections including meningitis and endopthalmitis. Several groups of patients are particularly susceptible to infection, including patients with diabetes mellitus, those from Southeast Asia and those with the preexisting hepatobiliary disease. We present a case of K.pneumoniae PLA with bacteremia. A 39-year-old Vietnamese male with no previous medical history who presented with complaints of abdominal pain, nausea, vomiting, diarrhea and fever...
January 10, 2017: Curēus
https://www.readbyqxmd.com/read/28190667/repeated-episodes-of-acute-stroke-as-manifestation-of-neurosyphilis-in-a-well-controlled-human-immunodeficiency-virus-infected-patient-successful-treatment-with-ceftriaxone
#13
Tsung-Chia Chen, Jen-Hsien Wang, Tzung-Chang Tsai
No abstract text is available yet for this article.
February 9, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28185856/exposure-to-%C3%AE-lactams-results-in-the-alteration-of-penicillin-binding-proteins-in-clostridium-perfringens
#14
Miseon Park, Fatemeh Rafii
Clostridium perfringens causes a variety of mild to severe infections in humans and other animals. A decrease in the affinity of penicillin-binding protein (PBP) transpeptidases for β-lactams is considered one of the mechanisms of β-lactam resistance in bacteria. Two strains of C. perfringens isolated from bovines and one isolated from a chicken, which had decreased susceptibility to β-lactams, had variations in the amino acid sequences of the central penicillin-binding regions of the PBPs. β-Lactam-resistant mutants of another C...
February 6, 2017: Anaerobe
https://www.readbyqxmd.com/read/28178114/resistance-to-ceftriaxone-and-azithromycin-in-neisseria-gonorrhoeae-isolates-from-7-countries-of-south-america-and-the-caribbean-2010-2011
#15
Sidharath Dev Thakur, Pamela Araya, Graciela Borthagaray, Patricia Galarza, Alina Llop Hernandez, Daisy Payares, Olga Marina Sanabria Cruz, Maria Elena Trigoso Carvallo, Aura Helena Corredor, Jo-Anne R Dillon
Seven countries in Latin America and the Caribbean report on (2010 and 2011) the susceptibility of 2235 isolates of Neisseria gonorrhoeae to 6 antibiotics. Thirteen isolates had ceftriaxone minimum inhibitory concentrations (MICs) of 0.125 to ≥ 0.25 mg/L. The percentage of resistant isolates to the following antibiotics was: azithromycin, 1.0% to 1.7%; ciprofloxacin, 42.1% to 36.2%; penicillin, 31% to 35%; tetracycline, 21.8% to 22.6%.
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178112/antimicrobial-susceptibility-of-neisseria-gonorrhoeae-in-japan-from-2000-to-2015
#16
Mitsuru Yasuda, Kyoko Hatazaki, Shin Ito, Masataka Kitanohara, Mutsumasa Yoh, Munekado Kojima, Harunori Narita, Akira Kido, Kazutoyo Miyata, Takashi Deguch
BACKGROUND: Gonococcal infections are difficult to treat because of their multidrug antimicrobial resistance. The outbreak of antimicrobial-resistant Neisseria gonorrhoeae has begun in Asia and particularly in Japan. Therefore, it is very important that we understand the trend of antimicrobial resistance of N. gonorrhoeae in Asia including Japan. Our surveillance of the antimicrobial susceptibility of N. gonorrhoeae began in 2000 under the guidance of the Department of Urology, Gifu University...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178108/a-hospital-based-case-control-study-of-diarrhea-in-children-in-shanghai
#17
Hailing Chang, Ling Zhang, Yanling Ge, Jiehao Cai, Xiangshi Wang, Zheng Huang, Jiayin Guo, Hao Xu, Zhen Gu, Hong Chen, Xuebin Xu, Mei Zeng
BACKGROUND: Prevention and control of childhood diarrhea is a global priority. We conducted a case-control study of childhood diarrhea in Shanghai. METHODS: We prospectively recruited diarrheal children in an outpatient setting. Non-diarrheal controls were individually matched to cases. Rotavirus, norovirus and bacterial pathogens were examined. Clinical and epidemiologic data were obtained at enrollment and follow-up. RESULTS: Potential pathogens identified in 680 diarrheal cases and 680 controls were rotavirus (19...
February 6, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28177803/a-survey-of-the-antimicrobial-susceptibility-of-escherichia-coli-isolated-from-sable-island-horses
#18
Mary E Timonin, Jocelyn Poissant, Philip D McLoughlin, Cherise E Hedlin, Joseph E Rubin
The feral horses of Sable Island are a geographically isolated population located ~160 km off the east coast of Nova Scotia, Canada. Because these horses have no contact with domestic animals, minimal contact with people and have never received antimicrobials, they offer a unique opportunity to study the dissemination of antimicrobial resistance in unmanaged populations. As part of an ongoing multi-disciplinary and individual-based monitoring program, we collected feces from 508 geolocalized horses (92 % of the total population) between July and September 2014...
November 7, 2016: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28174184/multiple-myeloma-presenting-with-bilateral-ankle-pain-microangiopathy-and-complicated-by-streptococcal-meningitis-and-pneumocystis-carinii-pneumonia
#19
Louise Dunphy, Neeraj Singh, Elizabeth Keating
Multiple myeloma is characterised by the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin. This clone of plasma cells proliferates in the bone marrow, resulting in extensive skeletal destruction with osteolytic lesions, osteopenia and pathological fractures. Additional disease-related complications include hypercalcaemia, renal insufficiency, anaemia and infection. We present the case of a 64-year-old woman presenting with rapid onset, painful distal symmetrical lower limb weakness and an acute kidney injury...
February 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28173648/-antibiotic-resistance-analysis-of-streptococcus-pneumoniae-isolates-from-the-hospitalized-children-in-shanxi-children-s-hospital-from-2012-to-2014
#20
L L Ge, Z Y Han, A H Liu, L Zhu, J H Meng
Objective: To investigate the antibiotic resistance status of Streptococcus pneumoniae isolates from hospitalized children in Shanxi Children's Hospital. Method: E-test and Kirby-Bauer methods were applied to determine drug sensitivity of the isolates collected from the body fluid specimens of hospitalized children in Shanxi Children's Hospital from January 2012 to December 2014. The antimicrobial sensitivity and minimum inhibitory concentration (MIC) of Streptococcus pneumoniae to the conventional antibiotics were analyzed, in order to compare the annual trends of non-invasive isolates, while the differentiation of sensitivity from specimens...
February 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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