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https://www.readbyqxmd.com/read/28807914/amplification-of-antimicrobial-resistance-in-gut-flora-of-patients-treated-with-ceftriaxone
#1
J Meletiadis, A Turlej-Rogacka, A Lerner, A Adler, E Taconelli, J W Mouton
Although antibacterial therapy has an impact on human intestinal flora and emergence of resistant bacteria, its role on amplification of antimicrobial resistance and the quantitative exposure-effect relationship is not clear. An observational prospective study was conducted to determine whether and how ceftriaxone exposure is related to amplification of resistance in non- ICU patients.Serial stool samples from 122 ESBL(+) hospitalized patients were analyzed with quantitative real-time PCR to quantify the resistant gene blaCTX-M Drug exposure was calculated for each patient using a population pharmacokinetic model...
August 14, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28804585/detection-of-ctx-m-15-among-uropathogenic-escherichia-coli-isolated-from-five-major-hospitals-in-tripoli-libya
#2
Abdulaziz Zorgani, Asma Almagatef, Najib Sufya, Abdulla Bashein, Abdullatif Tubbal
OBJECTIVES: Multidrug resistance (MDR) and emergence of extended-spectrum β-lactamases (ESBLs) among uropathogenic Escherichia coli have been reported worldwide, but there was no information on the detection of blaCTX-M-15 in major teaching hospitals in Libya. The aim of the study was to investigate the occurrence of CTX-M-15 β-lactamases producers isolated from five teaching hospitals in Tripoli, Libya. METHODS: A total of 346 urine samples were collected from hospitalized patients in five teaching hospitals with a diagnosis of urinary tract infection (UTI)...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28797299/prevalence-of-antimicrobial-drug-resistant-bacteria-carried-by-in-and-outpatients-attending-a-secondary-care-hospital-in-zambia
#3
Marjolijn M B Nagelkerke, Kapembwa Sikwewa, Dennis Makowa, Irene de Vries, Simon Chisi, J Wendelien Dorigo-Zetsma
OBJECTIVE: Antimicrobial resistance is an increasing global health problem. Very little data on resistance patterns of pathogenic bacteria in low-income countries exist. The aim of this study was to measure the prevalence of antimicrobial drug resistant bacteria carried by in- and outpatients in the resource constraint setting of a secondary care hospital in Zambia. Nasal and rectal samples from 50 in- and 50 outpatients were collected. Patients were randomly selected and informed consent was obtained...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28775247/spinal-abscess-caused-by-salmonella-bacteremia-in-a-patient-with-primary-myelofibrosis
#4
Shehab Fareed, Abdulqadir J Nashwan, Sulieman Abu Jarir, Ahmed Husain, Dina Sameh Suliman, Friyal Ibrahim, Abbas Moustafa, Muhammad S Akhter, Mohamed A Yassin
BACKGROUND In Primary Myelofibrosis (PMF; a clonal disorder arising from the neoplastic transformation of early hematopoietic stem cells) patients, spinal cord compression (SCC) is a common complication or even a presentation symptom due to extramedullary hematopoiesis (EMH). However, a case of SCC caused by a spinal abscess is unusual. To the best of our knowledge, this is the first case report of this rare condition. CASE REPORT We are reporting the case of a 50-year-old male with primary myelofibrosis and long-standing splenomegaly with back pain as a presenting symptom who was found to have spinal cord compression...
August 4, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28768443/neurobrucellosis
#5
Na Zheng, Wei Wang, Jia-Tang Zhang, Ya Cao, Long Shao, Jiao-Jiao Jiang, Xu-Sheng Huang, Cheng-Lin Tian, Sheng-Yuan Yu
Neurobrucellosis (NB) is a rare complication of brucellosis. NB presents with a variety of clinical manifestations, and the symptoms are always atypical. Our aim was to analyze the demographic characteristics, clinical manifestations, laboratory findings, imaging findings, treatments and outcomes of patients with NB. We retrospectively reviewed the data from 17 patients with NB hospitalized at the Chinese People's Liberation Army General Hospital between January 1, 2005 and October 31, 2016. The following symptoms were recorded: 10/17 (59%) patients had fever, and 9/17 (53%) patients had a disorder affecting urination and defecation...
August 3, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28764168/drug-resistance-pattern-in-the-recent-isolates-of-salmonella-typhi-with-special-reference-to-cephalosporins-and-azithromycin-in-the-gangetic-plain
#6
Shesh Raj Patel, Sujit Bharti, Chandra Bhan Pratap, Gopal Nath
INTRODUCTION: Typhoid fever is an endemic disease in India against which many antibiotics are available. In the recent times, emerging resistance to traditional antibiotics, such as Ampicillin, Chloramphenicol and Trimethoprim/sulfamethoxazole, Azithro-mycin and third generation Cephalosporins are being reported and increasingly being used in the treatment of invasive Salmonella infections. However, the latter two drugs have been reported with occasional clinical failures. Currently, we do not have data regarding their drug resistance levels in the recent isolates of Salmonella enterica subspecies enterica serotype Typhi...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763427/safety-of-outpatient-parenteral-antimicrobial-therapy-in-children
#7
Priyanka Fernandes, Carly Milliren, Helen M Mahoney-West, Laura Schwartz, Catherine S Lachenauer, Mari M Nakamura
BACKGROUND AND OBJECTIVE: Outpatient parenteral antimicrobial therapy (OPAT) provides numerous benefits but may pose unique risks in children. We aimed to determine rates of OPAT antimicrobial- and intravenous-access-related complications and their associations with specific antimicrobials and type of intravenous access in pediatric patients. METHODS: Observational cohort study of patients receiving OPAT from 8/2008 to 5/2015 cared for by the Infectious Diseases service at a tertiary children's hospital...
July 31, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28758816/the-interactions-of-cephalosporins-on-polyol-pathway-enzymes-from-sheep-kidney
#8
Bülent Şengül, Şükrü Beydemir
CONTEXT: Cephalosporins are derived from the fungus Acremonium. Due to their strong bactericidal ability, these drugs have to a wide usage in medicine. OBJECTIVE: An investigation of the effects on sheep renal aldose reductase (AR) and sorbitol dehydrogenase (SDH) of cefoperazone, cefazolin, cefuroxime, ceftazidime and ceftriaxone as cephalosporin drugs was carried out in the present study. METHODS: AR and SDH were purified from sheep kidney by ion exchange, gel filtration and affinity methods with approximately 219- and 484-fold, respectively...
July 31, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28757748/postoperative-herpetic-endophthalmitis-a-case-report
#9
Ya-Yun Yang, Yuan-Chieh Lee
We report a case of herpetic endophthalmitis following cataract surgery. A 65-year-old man underwent uneventful phacoemulsification and vision improved within the first few postoperative days. However, visual loss with an anterior chamber reaction of ++++ and a ++ vitreous cell were noted in the 4th postoperative week. Repeated intravitreal injection of vancomycin and ceftriaxone, pars plana vitrectomy and removal of the intraocular lens (IOL), and the capsular bag were performed sequentially but in vain. Bacterial, mycobacterial, and fungal culture of the IOL and capsular bag demonstrated negative findings...
October 2016: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28749999/synthesis-and-biological-evaluation-of-the-progenitor-of-a-new-class-of-cephalosporin-analogues-with-a-particular-focus-on-structure-based-computational-analysis
#10
Anna Verdino, Giovanni Vigliotta, Deborah Giordano, Ivana Caputo, Annunziata Soriente, Margherita De Rosa, Anna Marabotti
We present the synthesis and biological evaluation of the prototype of a new class of cephalosporins, containing an additional isolated beta lactam ring with two phenyl substituents. This new compound is effective against Gram positive microorganisms, with a potency similar to that of ceftriaxone, a cephalosporin widely used in clinics and taken as a reference, and with no cytotoxicity against two different human cell lines, even at a concentration much higher than the minimal inhibitory concentration tested...
2017: PloS One
https://www.readbyqxmd.com/read/28749571/l-ornithine-l-aspartate-in-bouts-of-overt-hepatic-encephalopathy
#11
Sandeep Singh Sidhu, Barjesh Chander Sharma, Omesh Goyal, Harsh Kishore, Navpreet Kaur
High quality data on efficacy of L-Ornithine L-Aspartate (LOLA) in cirrhotics with bouts of overt hepatic encephalopathy (OHE) is missing. We aimed to evaluate the efficacy of intravenous LOLA in reversal of bouts of OHE in cirrhotics. In this prospective double-blind randomized placebo controlled trial conducted at two tertiary care institutes in India, 370 cirrhotics with bouts of OHE were screened. After exclusion, 193 (52.16%) patients were randomized to receive either intravenous infusions of LOLA (n=98), 30 grams daily or Placebo (n=95) for 5 days...
July 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28747418/a-complication-of-meningitis-and-infective-endocarditis-due-to-streptococcus-pyogenes
#12
Kosuke Inoue, Akiyoshi Hagiwara, Akio Kimura, Norio Ohmagari
We described a rare case of meningitis and infective endocarditis (IE) due to Streptococcus pyogenes. An 80-year-old woman was admitted to our hospital with unconsciousness. Glasgow Coma Scale was E1V3M5. We diagnosed her with acute meningitis due to S. pyogenes and started treatment using ceftriaxone. In spite of the improvement of her unconscious state, she developed a new-onset systolic murmur on day 13, and echocardiography revealed severe mitral valve regurgitation with vegetation. Therefore, we also diagnosed her with IE and continued the antibiotics for 6 weeks after we confirmed the negative blood cultures...
July 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28742382/occurrence-and-antibiotic-susceptibility-of-listeria-species-and-staphylococcus-aureus-in-cattle-slaughterhouses-of-kerala-south-india
#13
Tanuja K G M Gowda, Latha C, Sunil B, Inge Van Damme
A total of 765 samples were collected from beef carcasses, knives, cutting table surfaces, beef, hands, air, and water from four cattle slaughterhouses of Kerala, South India, to determine the occurrence and antibiotic susceptibility of Listeria species and Staphylococcus aureus. Listeria spp. were isolated from beef carcasses (2.0%), knives (3.7%), cutting table surfaces (1.9%), beef (0.7%), and water (1.3%). The identified species were Listeria monocytogenes (0.1%), Listeria innocua (0.9%), and Listeria ivanovii (0...
July 25, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28741392/recent-advances-in-the-development-and-use-of-molecular-tests-to-predict-antimicrobial-resistance-in-neisseria-gonorrhoeae
#14
Valentina Donà, Nicola Low, Daniel Golparian, Magnus Unemo
The number of genetic tests, mostly real-time PCRs, to detect antimicrobial resistance (AMR) determinants and predict AMR in Neisseria gonorrhoeae is increasing. Several of these assays are promising, but there are important shortcomings and few assays have been adequately validated and quality assured. Areas covered: Recent advances, focusing on publications since 2012, in the development and use of molecular tests to predict gonococcal AMR for surveillance and for clinical use, advantages and disadvantages of these tests and of molecular AMR prediction compared with phenotypic AMR testing, and future perspectives for effective use of molecular AMR tests for different purposes...
August 3, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28741188/-sexually-transmitted-infections-in-germany-the-current-epidemiological-situation
#15
Viviane Bremer, Sandra Dudareva-Vizule, Susanne Buder, Matthias An der Heiden, Klaus Jansen
Sexually transmitted infections (STIs) can impair sexual health. Surveillance and study data were used to provide an overview over STIs in Germany. We estimated 3900 new HIV diagnoses in 2015. Of newly diagnosed infections, 57% were attributed to men who have sex with men (MSM). It was further estimated that there were 3200 new HIV infections and 84,700 people living with HIV in 2015. A total of 6834 syphilis infections were recorded in 2015, which corresponds to an increase of 149% since 2009. The incidence in men was 16-times higher than in women...
July 24, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28738899/a-rare-manifestation-of-burns-after-lightning-strike-in-rural-ghana-a-case-report
#16
Paschal Awingura Apanga, John Atigiba Azumah, Joseph Bayewala Yiranbon
BACKGROUND: Lightning is a natural phenomenon that mostly affects countries in the tropical and subtropical regions of the globe, including Ghana. Lightning strikes pose a global public health issue. Although strikes to humans are uncommon, it is associated with high morbidity and mortality. CASE PRESENTATION: We present a case of a 10-year-old Ghanaian girl who got second-degree burns after being struck by lightning. She was put on an intravenous broad-spectrum antibiotic (ceftriaxone), Ringer's lactate, and her burns were dressed with sterile gauze impregnated with Vaseline (petroleum jelly) and silver sulfadiazine ointment...
July 25, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28737858/the-effects-of-pneumococcal-conjugate-vaccine-pcv7-and-pcv13-on-turkish-children-with-invasive-pneumococcal-disease-a-single-center-experience
#17
Halil Özdemir, Caner Yıldız, Selin Nar Ötgün, Hatice Erkol, Adem Karbuz, Bilge Aldemir Kocabaş, Tuğçe Tural Kara, Ayşegül Gözalan, Rıza Durmaz, Ergin Çiftçi, Derya Aysev, Erdal İnce
INTRODUCTION: The aim of this prospective single-center study was to determine the changings in incidence of invasive pneumococcal disease (IPD), serotype distribution and the antimicrobial resistance patterns of S. pneumoniae in children with IPD after the period (1 to 7 years) of vaccination with PCV7 (2008) and PCV13 (2011). POPULATION AND METHODS: The study was conducted on 39 Turkish children with IPD between ages 1 month and 18 years in Ankara, Turkey. Streptococcus pneumoniae was identified using standard laboratory procedures from blood, cerebrospinal fluid (CSF), pleural fluid, and other sterile body fluids and tissues...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28735083/incidence-of-methicillin-resistant-staphylococcus-aureus-mrsa-in-microbial-community-of-cancer-patients-and-evaluation-of-their-resistant-pattern
#18
Mervat Morsy Abbas Ahmed El-Gendy, Ahmed Mohamed Ahmed El-Bondkly, Abeer Ali Keera, Amal Mohamed Ali
Cancer patients are prone to MRSA infection due to a number of factors include prolongedhospitalization, intravascular catheterization, compromised host immunity, malignancy, chemotherapy, radiotherapy surgery, prior antibiotic therapy and prolonged operative time. Among 468 Staphylococcus isolates, 283 were methicillin resistant Staphylococcus aureus isolates (MRSA), which indicated the occurrence and prevalence of MRSA isolates among cancer patients. The highest number of MRSA strains were isolated from male (124 isolates), female (90 isolates) followed by children (69 isolates) which represent 43...
July 19, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28735053/activity-of-dalbavancin-tested-against-gram-positive-clinical-isolates-causing-skin-and-skin-structure-infections-in-paediatric-patients-from-us-hospitals-2014-2015
#19
Michael A Pfaller, Rodrigo E Mendes, Helio S Sader, Mariana Castanheira, Robert K Flamm
OBJECTIVES: This study provides an in vitro analysis of dalbavancin activity against isolates causing skin and skin structure infections (SSSIs) in children. METHODS: 770 Staphylococcus aureus, 167 β-hemolytic streptococci (BHS), 42 coagulase-negative staphylococci (CoNS), 25 Enterococcus faecalis and 13 viridans group streptococci (VGS) were collected from children (<18 y/o) in the United States (2014-2015). RESULTS: Dalbavancin had MIC50/90 values of 0...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28729206/antimicrobial-resistance-patterns-of-gram-negative-bacteria-isolated-from-bloodstream-infections-in-an-iranian-referral-pediatric-hospital-a-six-year-study
#20
Shima Mahmoudi, Masoumeh Mahzari, Maryam Banar, Babak Pourakbari, Mohammad Taghi Haghi Ashtiani, Mohsen Mohammadi, Sepideh Keshavarz Valian, Setareh Mamishi
INTRODUCTION: Bloodstream infections (BSIs) are considered as a major cause of morbidity and mortality in children all over the world. The aim of this study was to describe the epidemiology and antimicrobial resistance patterns of Gram-negative bacteria (GNB) isolated from bloodstream infections (BSIs) in children admitted to the Children Medical Center Hospital (CMC), Tehran, Iran. METHODS: Clinical and microbiological data of the patients with positive blood cultures was collected from March 2011 to September 2016...
July 17, 2017: Journal of Global Antimicrobial Resistance
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