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Ceftriaxone

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https://www.readbyqxmd.com/read/28446572/evaluation-of-the-accelerate-pheno%C3%A2-system-for-fast-identification-and-antimicrobial-susceptibility-testing-from-positive-blood-culture-in-gram-negative-bloodstream-infection
#1
Matthias Marschal, Johanna Bachmaier, Ingo Autenrieth, Philipp Oberhettinger, Matthias Willmann, Silke Peter
Bloodstream infections (BSI) are an important cause of morbidity and mortality. Increasing rates of antimicrobial resistant pathogens limit treatment options, prompting an empirical use of broad-range antibiotics. Fast and reliable diagnostic tools are needed to provide adequate therapy in a timely manner and to enable a de-escalation of treatment.The Accelerate Pheno™ system (Accelerate Diagnostics, USA) is a fully automated test system that performs both identification (ID) and antimicrobial susceptibility testing (AST) directly from positive blood cultures within approx...
April 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28446378/ceftriaxone-susceptibility-and-molecular-characteristics-of-neisseria-gonorrhoeae-isolates-in-changsha-china
#2
Ting Peng, Hui Lin, Qinglin Liu, Wei Cao, Hui Ding, Jianlin Chen, Lingli Tang
A total of 128 Neisseria gonorrhoeae isolates were consecutively obtained in Changsha, China, between April 2015 and June 2016. The minimum inhibitory concentrations (MICs) of ceftriaxone were measured by agar dilution method for each isolate. Ceftriaxone resistance determinants involving penA, mtrR, porB and ponA were amplified by PCR, and the PCR products were sequenced. N. gonorrhoeae multi-antigen sequence typing (NG-MAST) was conducted for genotyping. The results exhibited 11% (14/128) of isolates were reduced susceptibility or resistant to ceftriaxone...
April 23, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28444315/towards-the-early-detection-of-%C3%AE-lactamase-producing-enterobacteriaceae-by-maldi-tof-ms-analysis
#3
Marina Oviaño, Marta Gómara, Maria José Barba, María José Revillo, Luis Pedro Barbeyto, Germán Bou
Objectives: Development of a novel MALDI-TOF MS-based method for the rapid detection of ESBL-producing Enterobacteriaceae. Methods: The method was evaluated in terms of sensitivity, specificity and turnaround time regarding the antibiotic used (cefotaxime, ceftazidime, ceftriaxone, cefpodoxime or cefepime) and the performance of the automated MBT STAR-BL software (Bruker Daltonik GmbH, Germany) relative to qualitative interpretation of spectra for detecting β-lactamase resistance by MALDI-TOF MS (Bruker Daltonik) in a collection of 11 isogenic Escherichia coli control strains expressing different β-lactamases...
April 24, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28443576/changes-in-bacterial-resistance-patterns-of-pediatric-urinary-tract-infections-in-%C3%A4-stanbul-and-rationale-for-empirical-antibiotic-therapy
#4
İbrahim Gökçe, Neslihan Çiçek, Serçin Güven, Ülger Altuntaş, Neşe Bıyıklı, Nurdan Yıldız, Harika Alpay
BACKGROUND: The causative agent spectrum and resistance patterns of urinary tract infection (UTI) in children are affected by many factors. AIMS: The aim of this study was to demonstrate the antibiotic resistance in UTI and changing ratio in antibiotic resistance by years. STUDY DESIGN: Retrospective cross-sectional study. METHODS: We analyzed antibiotic resistance patterns of isolated gram (-) bacteria during years 2011-2014 (study period 2) in children with UTI...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28439483/whipple-s-disease-manifested-as-recurrent-ascites
#5
Ali Aamar, Kamraan Madhani, Muhammad S Anwar, Prabhdeep Singh, Joel Garsten
Whipple's disease commonly presents as chronic diarrhea and abdominal pain. Ascites is an uncommon presentation of Whipple's disease. Here, we report a rare case of a 47-year-old male who presented with diarrhea and abdominal distention for three months. The physical examination was significant for ascites. Serum albumin was low and serum-to-ascites albumin gradient was < 1.1 g/dl. This suggested that ascites was less likely to be present due to portal hypertension. Enteroscopy showed erythematous duodenum and jejunum; biopsy was suggestive of periodic acid-Schiff stain (PAS) positive macrophages consistent with Whipple's disease...
March 21, 2017: Curēus
https://www.readbyqxmd.com/read/28439298/multi-drug-resistant-pathogenic-bacteria-in-the-gut-of-young-children-in-bangladesh
#6
Shirajum Monira, Syeda Antara Shabnam, Sk Imran Ali, Abdus Sadique, Fatema-Tuz Johura, Kazi Zillur Rahman, Nur Haque Alam, Haruo Watanabe, Munirul Alam
BACKGROUND: The gut of human harbors diverse commensal microbiota performing an array of beneficial role for the hosts. In the present study, the major commensal gut bacteria isolated by culturing methods from 15 children of moderate income families, aged between 10 and 24 months, were studied for their response to different antibiotics, and the molecular basis of drug resistance. RESULTS: Of 122 bacterial colonies primarily selected from Luria-Bertani agar, bacterial genera confirmed by analytical profile index (API) 20E(®) system included Escherichia as the predominant (52%) organism, followed by Enterobacter (16%), Pseudomonas (12%), Klebsiella (6%), Pantoea (6%), Vibrio (3%), and Citrobacter (3%); while Aeromonas and Raoultella were identified as the infrequently occurring genera...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28436267/pneumonia-with-pleural-empyema-caused-by-salmonella-typhi-in-an-immunocompetent-child-living-in-a-non-endemic-country
#7
Gwénaëlle Duhil de Bénazé, Emilie Desselas, Véronique Houdouin, Patricia Mariani-Kurkdjian, Ahmed Kheniche, Stéphane Dauger, Géraldine Poncelet, Jean Gaschignard, Michaël Levy
Extra-intestinal complications of Salmonella Typhi (S. Typhi) infections usually occur in endemic countries and in patients with underlying risk conditions. A 14-year-old immunocompetent girl was admitted with respiratory distress owing to S. Typhi pneumonia and pleural empyema. She was a native of Ivory Coast but had lived in France for 4 years and had not travelled abroad for several years. There were no gastro-intestinal symptoms and no S. Typhi carriage was detected in her family. She recovered completely with ceftriaxone and ciprofloxacin and pleural drainage was not required...
April 24, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28435202/phenotypic-and-genotypic-characterization-of-methicillin-resistant-staphylococcus-aureus-from-bovine-mastitis
#8
S Hamid, Mohd Altaf Bhat, Irfan Ahmad Mir, Anil Taku, Gulzar Ahmad Badroo, Salik Nazki, Andleeb Malik
AIM: This study was conducted to determine the occurrence of methicillin-sensitive and Staphylococcus aureus (MSSA) methicillin-resistant S. aureus (MRSA) from bovine mastitis and to characterize them with respect to antibiotic resistance gene mecA. MATERIALS AND METHODS: A total of 160 mastitic milk samples were screened for the presence of S. aureus. The presumptive positive isolates were confirmed using nuc and 23S rRNA gene-based polymerase chain reaction. All the confirmed isolates were subjected to in vitro antibiogram using a number of antibiotics...
March 2017: Veterinary World
https://www.readbyqxmd.com/read/28435078/preformulation-studies-of-ceftriaxone-for-pediatric-non-parenteral-administration-as-an-alternative-to-existing-injectable-formulations
#9
Tina Kauss, Mathieu Marchivie, Thida Phoeung, Alexandra Gaubert, Amélie Désiré, Giovanni Tonelli, Chantal Boyer, Marie-Hélène Langlois, Anthony Cartwright, Melba Gomes, Nicholas White, Karen Gaudin
Ceftriaxone, a third generation cephalosporin, has a wide antibacterial spectrum that has good CNS penetration, which makes it potentially suitable for initial treatment of severe neonatal pediatric infections providing suitable formulation. We evaluated its physicochemical and technical characteristics to assess its potential for development as a non-parenteral dosage form. As ceftriaxone is marked only for injectable use, these data are not available. Using HPLC and Karl Fischer titration, sensitivity of ceftriaxone to water, feasibility and impact of pharmaceutical processes and compatibility with common pharmaceutical excipients were assessed...
April 20, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28432206/identifying-factors-that-lead-to-the-persistence-of-imported-gonorrhoeae-strains-a-modelling-study
#10
Ben B Hui, David M Whiley, Basil Donovan, Matthew G Law, David G Regan
OBJECTIVE: The importation of Neisseria gonorrhoeae (NG) strains from overseas is believed to be the main source of antimicrobial resistance in Australia. With recent sporadic cases of ceftriaxone-resistant gonorrhoea reported in Australia and elsewhere, we sought to model the potential for imported NG strains to persist in the men who have sex with men (MSM) population in Australia. METHODS: We developed an individual-based model to simulate the transmission of NG in a population of urban MSM, and used this model to investigate factors contributing to the probability that an imported NG strain will persist...
May 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28431817/pneumococcal-carriage-among-children-after-four-years-of-routine-10-valent-pneumococcal-conjugate-vaccine-use-in-brazil-the-emergence-of-multidrug-resistant-serotype-6c
#11
Felipe P G Neves, Nayara T Cardoso, Robert E Snyder, Mariel A Marlow, Claudete A A Cardoso, Lúcia M Teixeira, Lee W Riley
BACKGROUND: In 2010, the 10-valent pneumococcal conjugate vaccine (PCV10) was introduced free of charge in Brazil as part of the public immunization program. Here we investigated the carriage prevalence, colonization risk factors, capsular types, and antimicrobial resistance among pneumococcal isolates obtained from children in Brazil four years after routine PCV10 use. METHODS: Between September and December 2014, we conducted a cross-sectional study among children<6years old who attended one public and two private clinics in Niterói, RJ, Brazil to evaluate pneumococcal nasopharyngeal carriage...
April 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28431096/a-new-rapid-resazurin-based-microdilution-assay-for-antimicrobial-susceptibility-testing-of-neisseria-gonorrhoeae
#12
Sunniva Foerster, Valentino Desilvestro, Lucy J Hathaway, Christian L Althaus, Magnus Unemo
Objectives: Rapid, cost-effective and objective methods for antimicrobial susceptibility testing of Neisseria gonorrhoeae would greatly enhance surveillance of antimicrobial resistance. Etest, disc diffusion and agar dilution methods are subjective, mostly laborious for large-scale testing and take ∼24 h. We aimed to develop a rapid broth microdilution assay using resazurin (blue), which is converted into resorufin (pink fluorescence) in the presence of viable bacteria. Methods: The resazurin-based broth microdilution assay was established using 132 N...
April 19, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28430425/environmental-growth-of-enterococci-and-escherichia-coli-in-feedlot-catch-basins-and-a-constructed-wetland-in-the-absence-of-fecal-input
#13
Lisa Tymensen, Calvin W Booker, Sherry J Hannon, Shaun R Cook, Rahat Zaheer, Ron Read, Tim A McAllister
Population structures of fecal indicator bacteria (FIB) isolated from catch basins, a constructed wetland, and feces from a beef cattle feedlot were compared over a two-year period. Enterococcus hirae accounted for 92% of the fecal isolates, whereas secondary environments were characterized by greater relative abundance of environmentally adapted species including Enterococcus casseliflavus. While enterococci densities in the catch basins and wetland were similar under wet and drought conditions, E. hirae predominated during rainy periods while E...
April 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28430086/genotypic-relatedness-and-antimicrobial-resistance-of-salmonella-heidelberg-isolated-from-chickens-and-turkeys-in-the-midwestern-united-states
#14
Muhammad Nisar, Issmat I Kassem, Gireesh Rajashekara, Sagar M Goyal, Dale Lauer, Shauna Voss, Kakambi V Nagaraja
Salmonella is one of the most common causes of foodborne illnesses in humans in the United States, and domestic poultry is considered an important source of this pathogen. Salmonella enterica subsp. enterica serovar Heidelberg is the fourth most commonly reported Salmonella from retail meats and food animals in the United States. We assessed the genotypes and antimicrobial resistance phenotypes of Salmonella Heidelberg isolated from various chicken and turkey hatcheries and breeder farms in the Midwest. The genotypes of 33 S...
May 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28428532/ceftriaxone-induced-hemolytic-anemia-in-a-jehovah-s-witness
#15
James Tasch, Pedro Gonzalez-Zayaz
BACKGROUND Drug-induced immune hemolytic anemia (DIIHA) is a rare condition that may result from the administration of an antibiotic, most notably the cephalosporin class, commonly used in both the adult and pediatric populations. A delay in recognition by a provider may lead to continuation of the offending agent and possibly result in fatal outcomes. CASE REPORT We report the case of a 65-year-old woman on ceftriaxone infusions after being diagnosed with acute mitral valve endocarditis 3 weeks prior, which presented with severe anemia and bilateral transient vision loss...
April 21, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28427474/assessment-of-surgical-antimicrobial-prophylaxis-in-orthopaedics-and-traumatology-surgical-unit-of-a-tertiary-care-teaching-hospital-in-addis-ababa
#16
Nitsuh Alemayehu Argaw, Kibruyisfawe Zewdie Shumbash, Alemseged Ayele Asfaw, Segewkal Hawaze
BACKGROUND: Prophylactic antimicrobials have a starring role in prevention of surgical site infection. This study assesses the practice of surgical antimicrobial prophylaxis (SAP) and development of surgical site infection (SSI) based on patient chart review in patients who underwent surgery in the Orthopaedics and Traumatology Surgical Unit of Tikur Anbesa Specialized Hospital (TASH). RESULTS: Majority of the patients 144 (72%) were males. 108 (54%) of the surgical wounds were clean and 63 (31%) were clean contaminated...
April 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28420242/high-prevalence-of-ndm-metallo-%C3%AE-lactamase-among-esbl-producing-escherichia-coli-%C3%A4-solates
#17
Yeliz Çetinkol, Cemal Sandalli, Mustafa Kerem Çalgin, Arzu Altunçekiç Yildirim, Esma Akyildiz, Esin Karaman, Ayşegül Çopur Çiçek
Resistance to β-lactams in Enterobacteriaceae has been increasing worldwide. This study aimed to determine the frequency of β-lactamase genes and antibiotic resistance rates of 140 extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates obtained from urinary tract infection in Ordu Province, Turkey. Isolates were identified by classic methods and by automated system. ESBL production was confirmed by double disk synergy test and antimicrobial susceptibility was investigated by disk diffusion method...
April 19, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28418316/amoxicillin-and-ceftriaxone-as-treatment-alternatives-to-penicillin-for-maternal-syphilis
#18
Yuichi Katanami, Takehiro Hashimoto, Saho Takaya, Kei Yamamoto, Satoshi Kutsuna, Nozomi Takeshita, Kayoko Hayakawa, Shuzo Kanagawa, Norio Ohmagari
There is no proven alternative to penicillin for treatment of maternal syphilis. We report 2 case-patients with maternal syphilis who were successfully treated without penicillin. We used amoxicillin and probenecid for the first case-patient and amoxicillin, probenecid, and ceftriaxone for the second case-patient.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28418303/azithromycin-resistance-and-decreased-ceftriaxone-susceptibility-in-neisseria-gonorrhoeae-hawaii-usa
#19
John R Papp, A Jeanine Abrams, Evelyn Nash, Alan R Katz, Robert D Kirkcaldy, Norman P O'Connor, Pamela S O'Brien, Derek H Harauchi, Eloisa V Maningas, Olusegun O Soge, Ellen N Kersh, Alan Komeya, Juval E Tomas, Glenn M Wasserman, Gail Y Kunimoto, David L Trees, A Christian Whelen
During 2016, eight Neisseria gonorrhoeae isolates from 7 patients in Hawaii were resistant to azithromycin; 5 had decreased in vitro susceptibility to ceftriaxone. Genomic analysis demonstrated a distinct phylogenetic clade when compared with local contemporary strains. Continued evolution and widespread transmission of these strains might challenge the effectiveness of current therapeutic options.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28416425/-bilateral-facial-nerve-palsy-associated-with-epstein-barr-virus-infection-in-a-3-year-old-boy
#20
M Grassin, A Rolland, N Leboucq, A Roubertie, F Rivier, P Meyer
Bilateral facial nerve palsy is a rare and sometimes difficult diagnosis. We describe a case of bilateral simultaneous facial nerve palsy associated with Epstein-Barr virus (EBV) infection in a 3-year-old boy. Several symptoms led to the diagnosis of EBV infection: the clinical situation (fever, stomachache, and throat infection), white blood cell count (5300/mm(3) with 70% lymphocyte count), seroconversion with EBV-specific antibodies, lymphocytic meningitis, and a positive blood EBV polymerase chain reaction (9...
April 14, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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