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https://www.readbyqxmd.com/read/30102612/adverse-effects-of-proton-pump-inhibitors-fact-or-fake-news
#1
Mitchell L Schubert
PURPOSE OF REVIEW: The present review summarizes the past year's literature, both clinical and basic science, regarding potential adverse effects of proton pump inhibitors. RECENT FINDINGS: Proton pump inhibitors are amongst the most widely prescribed and overprescribed medications worldwide. Although generally considered well tolerated, epidemiologic studies mining large databases have reported a panoply of purported serious adverse effects associated with proton pump inhibitors, including chronic kidney disease, cognitive decline, myocardial infarction, stroke, bone fracture and even death...
August 9, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/30101874/-rupture-of-small-intestinal-varices-diagnosed-by-ctap-and-gastrointestinal-bleeding-scintigraphy-and-treated-by-percutaneous-phlebosclerozation-angioembolization
#2
Tomohiro Kamio, Seiji Kawano, Hideki Onishi, Yuka Obayashi, Atsushi Oyama, Kazuhiro Nouso, Keita Harada, Hiroyuki Okada, Hiroyasu Fujiwara, Yu Kanazawa
A 55-year-old man was admitted to our hospital because of massive gastrointestinal bleeding. He had a history of type B liver cirrhosis, multiple abdominal surgeries, and endoscopic treatment of esophageal varices. Colonoscopy was performed, but the source of bleeding could not be identified. Computed tomography during arterial portography (CTAP) demonstrated small intestinal varices and collateral veins from the superior mesenteric vein to the epigastric vein. We performed phlebosclerozation by directly puncturing the epigastric vein under the skin...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/30101529/re-evaluating-the-utility-of-stress-ulcer-prophylaxis-in-the-critically-ill-patient-a-clinical-scenario-based-meta-analysis
#3
Paul M Reynolds, Rob MacLaren
STUDY OBJECTIVE: As recent studies have challenged the efficacy of stress ulcer prophylaxis (SUP) in the critically ill patient, the objective of this study was to evaluate the efficacy of SUP with proton pump inhibitors (PPIs) or histamine2 receptor antagonists (H2 RAs) against placebo, control, no therapy, or enteral nutrition alone in critically ill adults. DESIGN: Meta-analysis with trial sequential analysis (TSA) of 34 randomized controlled trials. PATIENTS: A total of 3220 critically ill adults who received PPIs or H2 RAs versus placebo, control, no therapy, or enteral nutrition...
August 13, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/30101131/diagnosis-pathological-findings-and-clinical-management-of-gangliocytic-paraganglioma-a-systematic-review
#4
Yoichiro Okubo, Emi Yoshioka, Masaki Suzuki, Kota Washimi, Kae Kawachi, Yoichi Kameda, Tomoyuki Yokose
Background: Although gangliocytic paraganglioma (GP) is considered a rare benign neuroendocrine tumor, cases of mortality have been reported. Occasionally, GP is misdiagnosed as neuroendocrine tumor G1, which is associated with a poorer prognosis than GP. To avoid such misdiagnoses, it is important to understand the clinicopathological characteristics of GP. Thus, herein, we discuss the current literature on the clinicopathological characteristics of GP. Methods: We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30100584/joint-recommendations-on-management-of-anaemia-in-patients-with-gastrointestinal-bleeding-in-hong-kong
#5
L Y Mak, C W Lau, Y T Hui, C Ng, E Shan, M Kk Li, J Yw Lau, P Wy Chiu, H T Leong, J Ho, J Cy Wu, C K Lee, W K Leung
The demand for blood products continues to grow in an unsustainable manner in Hong Kong. While anaemia associated with gastrointestinal bleeding (GIB) is the leading indication for transfusion, there is no local recommendation regarding best practices for transfusion. We aimed to provide evidence-based recommendations regarding management of anaemia in patients with acute and chronic GIB. We reviewed all original papers, meta-analyses, systematic reviews, or guidelines that were available in PubMed. For acute GIB, a restrictive transfusion strategy, targeting a haemoglobin threshold of 7 to 8 g/dL, should be adopted because overtransfusion is associated with significantly higher all-cause mortality and re-bleeding...
August 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/30099888/clinical-safety-outcomes-in-patients-with-nonvalvular-atrial-fibrillation-on-rivaroxaban-and-diltiazem
#6
Jenna W Bartlett, Elizabeth Renner, Erin Mouland, Geoffrey D Barnes, Liane Kuo, Nghi B Ha
BACKGROUND: It is unknown whether diltiazem, a moderate cytochrome P450 enzyme (CYP3A4) and P-glycoprotein (P-gp) inhibitor, increases the incidence of bleeding events in combination with rivaroxaban, a CYP3A4 and P-gp substrate. OBJECTIVE: To assess major and clinically relevant nonmajor (CRNM) bleeding outcomes in patients with nonvalvular atrial fibrillation (NVAF) on rivaroxaban with concomitant diltiazem in a real-world setting. METHODS: This retrospective case-cohort study included adult patients with NVAF prescribed both rivaroxaban and diltiazem for at least 30 days...
August 13, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/30099397/efficacy-and-tolerance-of-early-administration-of-tranexamic-acid-in-patients-with-cirrhosis-presenting-with-acute-upper-gastrointestinal-bleeding-a-study-protocol-for-a-multicentre-randomised-double-blind-placebo-controlled-trial-the-exarhose-study
#7
Matthieu Heidet, Roland Amathieu, Etienne Audureau, Oriane Augusto, Violaine Nicolazo de Barmon, Amandine Rialland, David Schmitz, François Pierrang, Jean Marty, Charlotte Chollet-Xémard, Olivier Thirion, Line Jacob
INTRODUCTION: The management of acute upper gastrointestinal bleeding (UGIB) is challenging in patients with cirrhosis, as it is responsible for severe complications and high mortality rates. Tranexamic acid (TXA) may help control the bleeding by counterbalancing cirrhosis-related hyperfibrinolysis. Still, there is a lack of unbiased data to conclude on its efficacy. The aim of this study is to evaluate the efficacy of TXA in the early treatment of acute UGIB in patients with cirrhosis...
August 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/30099106/when-to-resume-direct-oral-anticoagulants-following-gastrointestinal-bleeding
#8
EDITORIAL
Moe H Kyaw, Francis K L Chan
No abstract text is available yet for this article.
August 9, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30098914/pathophysiology-of-severe-fever-with-thrombocytopenia-syndrome-and-development-of-specific-antiviral-therapy
#9
REVIEW
Masayuki Saijo
Severe fever with thrombocytopenia syndrome (SFTS) caused by SFTS virus (SFTSV), a novel phlebovirus, was reported to be endemic to central and northeastern PR China and was also to be endemic to South Korea and western Japan. SFTS is an emerging viral infection, which should be categorized as a viral hemorrhagic fever disease as Crimean-Congo hemorrhagic fever (CCHF) is caused by CCHF virus. SFTS is a tick-borne viral infection. SFTSV is maintained between several species of ticks and wild and domestic animals in nature...
August 8, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/30098596/management-of-a-case-of-high-risk-gastrointestinal-stromal-tumor-in-rectum-by-transanal-minimal-invasive-surgery
#10
Pramod Nepal, Shinichiro Mori, Yoshiaki Kita, Kan Tanabe, Kenji Baba, Yasuto Uchikado, Hiroshi Kurahara, Takaaki Arigami, Masahiko Sakoda, Kosei Maemura, Shoji Natsugoe
BACKGROUND: Rectal gastrointestinal stromal tumor (GIST) is a very rare tumor of gastrointestinal tract. Surgical management of rectal GIST requires special attention for preserving of anal and urinary functions. Transanal minimal invasive surgery (TAMIS) is a well-developed minimally invasive technique for local excision of benign and early malignant rectal tumors; however, the application of TAMIS for rectal GIST is rarely and inadequately reported. We report the novel application of TAMIS for rectal GIST with considerations for anal and urinary functions...
August 11, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30095650/a-case-report-of-pulmonary-arterial-hypertension-in-pregnancy-and-complications-of-anticoagulation-therapy
#11
Yangfang Xiang, Jun Li, Yinxiang Sun
RATIONALE: Treprostinil, a potent vasodilator, is the treatment of choice for severe pulmonary arterial hypertension (PAH) during pregnancy. Its inhibition of platelet aggregation increases the risk of hemorrhage. In addition, anticoagulation therapy is widely used in pregnancy with PAH due to the hypercoagulable state. However, very little is known about the complications of anticoagulants' use in pregnancy with PAH. PATIENT CONCERNS: A 27-year-old pregnant woman was admitted to the hospital at 32weeks with progressive dyspnea...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30095019/upper-gastrointestinal-bleeding-in-critically-ill-patients-ppis-h2ras-or-placebo-many-questions-remain-unanswered
#12
Guillermo García-Rayado, Angel Lanas
No abstract text is available yet for this article.
August 10, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/30094594/pyogenic-granuloma-of-the-ampulla-of-vater-unexpected-cause-of-gastrointestinal-bleeding
#13
Helena Moreira Silva, Gisela Silva, Emília Costa, Rosa Lima, Fernando Pereira
We describe the case of a previously healthy 8-year-old girl presenting with a 1-year history of iron deficiency anemia. There was no report of hematemesis, abdominal pain or melena. Laboratory work-up excluded iron malabsorption as the underlying cause. Therefore, endoscopic evaluation was performed to exclude gastrointestinal blood loss, which revealed the presence of a 7 mm reddish lesion located within the ampulla of Vater. Capsule endoscopy excluded alternative diagnoses and concomitant lesions. Histopathological examination confirmed the diagnosis of pyogenic granuloma...
August 9, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/30094254/adhering-to-quality-medical-care-a-case-report-of-upper-gastrointestinal-bleeding-due-to-self-expandable-metal-stent-placed-for-benign-duodenal-obstruction
#14
Polychronis Gatos-Gatopoulos, Georgios Tziatzios, Paraskevas Gkolfakis, Konstantinos Triantafyllou
Endoscopic placement of self-expandable metal stent (SEMS) is an efficient method for the palliative decompression of malignant gastro duodenal obstruction. However, its role in treating benign obstructive conditions is controversial. We herein present an unusual case of recurrent upper gastrointestinal (GI) bleeding episodes due to ischemic lesions induced by an uncovered SEMS placed several years before to treat post peptic ulcer pyloric obstruction. Patient's advanced age precluded any attempt for endoscopic or surgical removal of the stent and the patient was successfully treated only with proton pump inhibitors, remaining uneventful on the long term...
July 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30094114/gastrointestinal-bleed-from-erosive-gastritis-and-duodenitis-a-sentinel-event-of-invasive-lobular-carcinoma-of-the-breast-and-a-diagnostic-dilemma
#15
Mark Bilinyi Ulanja, Mohamed Taha, Arshad Al-Mashhadani, Bryce D Beutler, Marwah Al-Tekreeti, Christie Elliot, Santhosh Ambika
Metastasis from breast cancer to the gastrointestinal (GI) tract is uncommon, and such events presenting as GI bleeding are exceedingly rare. In some individuals, the absence of classical findings of primary breast cancer coupled with the non-specific nature of GI symptoms may make early detection and diagnosis challenging. Our patient is a 75-year-old female who presented with symptomatic anemia manifesting as progressive dizziness, weakness, and early satiety that developed eight days after right knee arthroplasty...
June 7, 2018: Curēus
https://www.readbyqxmd.com/read/30090045/risk-factors-for-severity-of-colonic-diverticular-hemorrhage
#16
Ken Kinjo, Toshiyuki Matsui, Takashi Hisabe, Hiroshi Ishihara, Toshiki Kojima, Kenta Chuman, Shigeyoshi Yasukawa, Tsuyoshi Beppu, Akihiro Koga, Satoshi Ishikawa, Masahiro Kishi, Noritaka Takatsu, Fumihito Hirai, Kenshi Yao, Toshiharu Ueki, Masakazu Washio
Background/Aims: Colonic diverticular hemorrhage (DH) was a rare disease until the 1990s, and its incidence has increased rapidly since 2000 in Japan. In recent years, colonic DH has been the most frequent cause of lower gastrointestinal bleeding (LGIB). Nearly all cases of DH are mild, with the bleeding often stopping spontaneously. Some cases, however, require surgery or arterial embolization. In this study, using a cohort at Fukuoka University Chikushi Hospital, we investigated factors associated with severe colonic DH...
July 2018: Intestinal Research
https://www.readbyqxmd.com/read/30086784/hyperfractionated-abdominal-reirradiation-for-gastrointestinal-malignancies
#17
Andrew Hunt, Prajnan Das, Bruce D Minsky, Eugene J Koay, Sunil Krishnan, Joseph M Herman, Cullen Taniguchi, Albert Koong, Grace L Smith, Emma B Holliday
BACKGROUND: We sought to determine the role of abdominal reirradiation for patients presenting with recurrent or new primary gastrointestinal (GI) malignancies. At our institution, we have established a hyperfractionated, accelerated reirradiation regimen consisting of 39 Gray (Gy) in 26 twice-daily fractions. Although this regimen is used frequently in the pelvis, we sought to determine its toxicity and efficacy for abdominal tumors. METHODS: Twenty-four patients who received abdominal reirradiation with a hyperfractionated, accelerated approach from 2000 to 2017 were identified...
August 7, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/30086576/long-term-results-after-diversion-surgery-in-extrahepatic-portal-vein-obstruction
#18
Paloma Triana Junco, Ana Alvarez, Mariela Dore, Javier Jimenez Gomez, Alba Sánchez Galán, Alejandra Vilanova-Sánchez, Ane Andres, Jose Luis Encinas, Leopoldo Martinez, Francisco Hernandez, Manuel Lopez Santamaria
AIM:  Extrahepatic portal vein obstruction (EHPVO) is a frequent cause of noncirrhotic portal hypertension in children. The aim of this study is to analyze long-term results after diversion surgery. PATIENTS AND METHODS:  Retrospective review of EHPVO patients who underwent diversion surgery analyzing number of platelets, leukocytes, prothrombin activity, splenomegaly, and gastrointestinal bleeding 10 years after surgery. RESULTS:  Thirty-three patients were evaluated, mostly males (64%) and presenting with gastrointestinal bleeding (46%)...
August 7, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/30086478/primary-aortoduodenal-fistula-a-case-report-and-review-of-literature
#19
Tohru Ishimine, Toshiho Tengan, Hiroshi Yasumoto, Akio Nakasu, Hidemitsu Mototake, Yuya Miura, Kyohei Kawasaki, Takashi Kato
BACKGROUND: Primary aortoduodenal fistula (PADF) is an abnormal connection between the aorta and the duodenum and is a life-threatening condition. It is a very rare cause of gastrointestinal bleeding, which often leads to delay in its diagnosis. Prompt diagnosis and surgical treatment are crucial to improve the outcome of patients with PADF. PRESENTATION OF CASE: An 82-year-old man with a history of untreated abdominal aortic aneurysm (AAA) presented to the emergency department with hematemesis...
July 26, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30083589/video-capsule-endoscopy-as-a-tool-for-evaluation-of-obscure-overt-gastrointestinal-bleeding-in-the-intensive-care-unit
#20
Shahrad Hakimian, Salmaan Jawaid, Yurima Guilarte-Walker, Jomol Mathew, David Cave
Background and study aims:  Video capsule endoscopy (VCE) is a minimally invasive tool that helps visualize the gastrointestinal tract from the esophagus to the right colon without the need for sedation or preparation. VCE is safe with very few contraindications. However, its role and safety profile in the intensive care unit (ICU) population have not been reported. The aim of this study is to evaluate the safety, efficacy, and feasibility of VCE use in ICU patients. Patients and methods:  We conducted a single-center retrospective observational study of patients who underwent VCE for evaluation of obscure overt gastrointestinal bleeding in the ICU between 2008 and 2016...
August 2018: Endoscopy International Open
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