Geraldine Blanchard-Rohner, Robert J Ragotte, Anne K Junker, Mehul Sharma, Kate L Del Bel, Henry Y Lu, Stephanie Erdle, Alanna Chomyn, Harinder Gill, Lori B Tucker, Richard A Schreiber, Jacob Rozmus, Catherine M Biggs, Kyla J Hildebrand, John Wu, Sylvia Stockler-Ipsiroglu, Stuart E Turvey
BACKGROUND: KRAS (KRAS proto-oncogene, GTPase; OMIM: 190,070) encodes one of three small guanosine triphosphatase proteins belonging to the RAS family. This group of proteins is responsible for cell proliferation, differentiation and inhibition of apoptosis. Gain-of-function variants in KRAS are commonly found in human cancers. Non-malignant somatic KRAS variants underlie a subset of RAS-associated autoimmune leukoproliferative disorders (RALD). RALD is characterized by splenomegaly, persistent monocytosis, hypergammaglobulinemia and cytopenia, but can also include autoimmune features and lymphadenopathy...
January 21, 2021: BMC Pediatrics