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optical coherence tomography angiogram

Jingjiang Xu, Yuandong Li, Shaozhen Song, William Cepurna, John Morrison, Ruikang K Wang
We report the development of a 1300 nm swept-source optical coherence tomography (SS-OCT) system specifically designed to perform OCT imaging and optical microangiography (OMAG) in rat eyes in vivo and its use in evaluating the effects of intraocular pressure (IOP) elevation on ocular circulation. The swept laser is operated in single longitude mode with a 90 nm bandwidth centered at 1300 nm and 200 kHz A-line rate, providing remarkable sensitivity fall-off performance along the imaging depth, a larger field of view of 2...
September 26, 2018: Microvascular Research
Qinqin Zhang, Yingying Shi, Hao Zhou, Giovanni Gregori, Zhongdi Chu, Fang Zheng, Elie H Motulsky, Luis de Sisternes, Mary Durbin, Philip J Rosenfeld, Ruikang K Wang
Background: To estimate choriocapillaris flow deficits beyond normal intercapillary distance with swept source optical coherence tomography angiography (SS-OCTA). Methods: Subjects were enrolled and repeated SS-OCTA scans were performed using the 3 mm × 3 mm scan pattern. Blood flow was identified using the complex optical microangiography (OMAGc ) algorithm. The choriocapillaris (CC) was defined as a 20 µm slab of the flow volume beneath the outer boundary of Bruch's membrane (BM) and was compensated with the corresponding structural image for flow deficits measurement...
August 2018: Quantitative Imaging in Medicine and Surgery
Felice Cardillo Piccolino, Marco Lupidi, Carlo Cagini, Daniela Fruttini, Massimo Nicolò, Chiara Maria Eandi, Silvia Tito
Purpose: To investigate the retinal vascular response to the isometric exercise in patients with central serous chorioretinopathy (CSCR) by using optical coherence tomography angiography (OCT-A). Methods: This was a multicenter case-control study including 35 CSCR patients and 25 age-matched healthy controls. All subjects underwent macular OCT-A scans in resting conditions and during a handgrip isometric exercise. Hemodynamic data, such as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and ocular perfusion pressure (OPP), were recorded at baseline and during the stress test...
September 4, 2018: Investigative Ophthalmology & Visual Science
Sho Hashimoto, Akihiko Takahashi, Yukio Mizuguchi, Takeshi Yamada, Norimasa Taniguchi, Tetsuya Hata, Shunsuke Nakajima
We aimed to evaluate the impact of tissue characterization for in-stent restenosis (ISR) with optical computed tomography (OCT) during excimer laser coronary angioplasty (ELCA) in the drug-eluting stent (DES) era. The effect of ELCA for ISR according to differences in tissue characteristics is unclear. Fifty-three ISR lesions (7 bare metal stents and 46 drug-eluting stents) were treated with an ELCA catheter. After ELCA, balloon dilatation with either the scoring or non-compliant balloons was conducted. The procedure was completed by applying a drug-coated balloon...
August 22, 2018: Cardiovascular Intervention and Therapeutics
Kim Vieira Kayat, Luiz Roisman, Claudio Zett, Eduardo A Novais, Michel Eid Farah
BACKGROUND AND OBJECTIVE: To illustrate how optical coherence tomography (OCT) angiography (OCTA) can be misinterpreted if not evaluated along with structural en face OCT to analyze the signal intensity. PATIENTS AND METHODS: Patients with different macular diseases associated with suspicious flow impairment in the choriocapillaris were recruited to be imaged on the RTVue XR Avanti device (Optovue, Fremont, CA) with the Angio Retina mode. En face OCT angiograms, structural en face OCT, and corresponding OCT B-scans with flow signal overlaid were compared to evaluate the correspondence of signal strength to areas of flow reduction in the choriocapillaris...
August 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Florian Blachutzik, Stephan Achenbach, Mohamed Marwan, Jens Röther, Monique Tröbs, Reinhard Schneider, Holger Nef, Melissa Weissner, Christian Schlundt
BACKGROUND: Coronary evaginations can occur after implantation of bioresorbable vascular scaffolds (BRS) and may be associated with scaffold thrombosis. Aim of this study was to clarify the clinical manifestation, extent and time course of coronary artery remodeling in vessel segments that develop angiographically detectable evaginations following BRS implantation through optical coherence tomography (OCT) analysis. METHODS: In 8 patients, 10 BRS (Absorb, Abbott Vascular, Santa Clara, CA, USA) which displayed coronary evaginations in clinically driven late invasive coronary angiograms were identified and findings were compared to 10 BRS in 8 patients without coronary evaginations...
August 4, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Fupeng Wang, Qinqin Zhang, Anthony J Deegan, Jun Chang, Ruikang K Wang
Background: There are two forms of system implementation of optical coherence tomography angiography (OCTA) in ophthalmic imaging, i.e., spectral domain (SD-) and swept source OCTA (SS-OCTA). The purpose of this paper is to compare the SD-OCTA and SS-OCTA for elucidating structural and vascular features associated with central serous retinopathy (CSR), and to evaluate the effects of CSR on SD- and SS-OCTA's imaging capabilities. Methods: Normal subjects and CSR patients were imaged by SD- and SS-OCTA using 3 × 3 mm and 6 × 6 mm scan patterns...
2018: Eye and Vision (London, England)
Alessio Cerquaglia, Barbara Iaccheri, Tito Fiore, Daniela Fruttini, Federica Benedetta Belli, Moncef Khairallah, Marco Lupidi, Carlo Cagini
PURPOSE: To report optical coherence tomography angiography (OCT-A) findings in eyes with ocular sarcoidosis (OS) and to compare these findings with those of fluorescein angiography (FA). METHODS: Observational, cross-sectional, case-control study. Patients presenting with OS involving the posterior segment were evaluated using FA, structural-OCT and OCT-A. OCT-angiograms of the superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC) were qualitatively and quantitatively analyzed...
August 6, 2018: Ocular Immunology and Inflammation
Felice Cardillo Piccolino, Marco Lupidi, Carlo Cagini, Daniela Fruttini, Massimo Nicolò, Chiara Maria Eandi, Silvia Tito
Purpose: To investigate by optical coherence tomography angiography (OCT-A) the choroidal vascular response to experimentally increased blood pressure in patients with central serous chorioretinopathy (CSCR). Methods: For this multicenter, observational, case-control study, we enrolled 35 patients with an established diagnose of CSCR and 25 age-matched healthy controls. All subjects underwent a handgrip isometric exercise to obtain elevation of blood pressure (BP)...
August 1, 2018: Investigative Ophthalmology & Visual Science
Joana Delgado-Silva, Raquel Fernandes, Inês R Pita, Frederico C Pereira, Milosz Jaguszewski, Juan Luis Gutiérrez-Chico, Teresa Ribeiro-Rodrigues, Henrique Girão, Adam Ioannou, Lino Gonçalves
The purpose of this study was to evaluate the impact of prebifurcation renal denervation in a swine model and assess its safety through optical coherence tomography (OCT). Prebifurcation renal denervation with a multi-electrode catheter was performed in one renal artery of 12 healthy pigs, with the contralateral artery and kidney being used as controls. Angiograms and OCT pullbacks were obtained peri-procedurally and 1 month post procedure. Renal tissue catecholamines were quantified, and the arterial wall and peri-adventitial tissue were analyzed histologically...
July 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Joseph J Raevis, Ksenia Denisova, Elzbieta Mechel, Eric M Shrier
BACKGROUND/PURPOSE: Report a case of markedly asymmetric retinal tessellations and propose mosaicism as a mechanism. METHODS AND RESULTS: A 59-year-old pseudophakic woman presented with uncorrected 20/20 vision and was found to have markedly different retinal tessellation appearances in both eyes. The axial lengths were 25.66 mm and 25.88 mm in the right and left eyes, respectively, and no significant asymmetrical choroidal thinning was seen on optical coherence tomography or optical coherence tomography angiography...
July 10, 2018: Retinal Cases & Brief Reports
Yasin Sakir Goker, Kemal Tekin, Cemile Ucgul Atilgan, Pinar Kosekahya, Pelin Yilmazbas
A 27-year-old male was presented with a sudden onset of visual loss in his right eye. A secondary care center referred the patient with fundus photographs which were screened 4 days before and after the Nd: YAG laser hyaloidotomy treatment. Snellen acuity was 10/10 in both eyes. Fundus examinations revealed a retinal pigment epithelium (RPE) alteration at the margin of the inferior temporal arterial vascular arcade in the right eye and resolved preretinal and subretinal hemorrhages were seen in the macula. A diagnosis of Valsalva retinopathy was made based on the history and the treatment photographs of Nd:YAG laser hyaloidotomy...
2018: Case Reports in Ophthalmological Medicine
Karl M Andersen, Lydia Sauer, Rebekah H Gensure, Martin Hammer, Paul S Bernstein
Purpose: We investigated fundus autofluorescence (FAF) lifetimes in patients with retinitis pigmentosa (RP) using fluorescence lifetime imaging ophthalmoscopy (FLIO). Methods: A total of 33 patients (mean age, 40.0 ± 17.0 years) with RP and an age-matched healthy group were included. The Heidelberg FLIO was used to detect FAF decays in short (SSC; 498-560 nm) and long (LSC; 560-720 nm) spectral channels. We investigated a 30° retinal field and calculated the amplitude-weighted mean fluorescence lifetime (τm )...
June 2018: Translational Vision Science & Technology
Geraud Souteyrand, Louis Viallard, Nicolas Combaret, Bruno Pereira, Guillaume Clerfond, Guilhem Malcles, Nicolas Barber Chamoux, Francesco Prati, Pascal Motreff
BACKGROUND: A two-step strategy of invasive management without stenting, guided by optical coherence tomography (OCT), in selected patients with acute coronary syndrome (ACS), might avoid systematic stent implantation and allow medical therapy alone. AIMS: To assess the feasibility and safety of such a procedure, and to define coronary imaging characteristics in a specific population. METHODS: This single-centre proof-of-concept study included all patients with ACS who benefited from a two-step revascularization procedure with optimal reperfusion during primary percutaneous coronary intervention followed by delayed angiography and OCT...
June 19, 2018: Archives of Cardiovascular Diseases
Maged Alnawaiseh, Christian Ertmer, Laura Seidel, Philip Helge Arnemann, Larissa Lahme, Tim-Gerald Kampmeier, Sebastian Willy Rehberg, Peter Heiduschka, Nicole Eter, Michael Hessler
BACKGROUND: This study aimed to investigate the feasibility of optical coherence tomography angiography (OCT-A) for quantitative analysis of flow density to assess changes in retinal perfusion in an experimental model of haemorrhagic shock. METHODS: Haemorrhagic shock was induced in five healthy, anaesthetized sheep by stepwise blood withdrawal of 3 × 10 ml∙kg- 1 body weight. OCT-A imaging of retinal perfusion was performed using an OCT device. Incident dark-field illumination microscopy videos were obtained for the evaluation of conjunctival microcirculation...
May 29, 2018: Critical Care: the Official Journal of the Critical Care Forum
S Serafini, C P Lohmann, M Ulbig
A 28-year-old female patient came to our clinic complaining of small central visual field defects in both eyes, without any impairments of visual acuity. She reported recent flu-like symptoms and work-related stress associated with high caffeine intake. Dark reddish cloverleaf-shaped lesions were noted in the macular region with red-free fundoscopy, and alterations of the external retinal layers were observed in spectral domain optical coherence tomography (SD-OCT). The visual field test (Octopus, program 32) revealed small central scotoma on both eyes...
May 24, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Maged Alnawaiseh, Cristin Brand, Eike Bormann, Cristina Sauerland, Nicole Eter
BACKGROUND: The aim of the study was to evaluate the impact of integration of the eye-tracking system (ET) on the repeatability of flow density measurements using optical coherence tomography (OCT) angiography. METHODS: 20 healthy subjects were included in this study. OCT-angiography was performed using RTVue XR Avanti (Optovue Inc., Fremont, California, USA). The macula was imaged using a 3 × 3 mm scan twice with and twice without activation of the ET. Flow density data of the macular in the superficial and deep OCT angiograms were extracted and analyzed...
May 24, 2018: BMC Ophthalmology
Paul Shin, WooJhon Choi, JongYoon Joo, Wang-Yuhl Oh
Functional hyperemia in the rat cortex was investigated using high-speed optical coherence tomography (OCT) angiography and Doppler OCT. OCT angiography (OCTA) was performed to image the hemodynamic stimulus-response over a wide field of view. Temporal changes in vessel diameters in different vessel compartments, which were determined as the diameters of erythrocyte flows in OCT angiograms, were measured in order to monitor localized hemodynamic changes. Our results showed that the dilation of arterioles at the site of activation was accompanied by the dilation of upstream arteries...
May 14, 2018: Journal of Cerebral Blood Flow and Metabolism
Noriaki Moriyama, Koki Shishido, Yutaka Tanaka, Shohei Yokota, Takahiro Hayashi, Hirokazu Miyashita, Tatsuya Koike, Hiroaki Yokoyama, Takuma Takada, Takashi Nishimoto, Tomoki Ochiai, Kazuki Tobita, Futoshi Yamanaka, Shingo Mizuno, Masato Murakami, Saeko Takahashi, Shigeru Saito
BACKGROUND: Data regarding neoatherosclerosis after everolimus-eluting bioresorbable vascular scaffold (BVS) (ABSORB BVS Rev. 1.1, Abbott Vascular, Santa Clara, California) implantation are limited. OBJECTIVES: This study investigated the findings of neoatherosclerosis at 5 years after BVS 1.1 implantation by using multi-imaging modalities, including optical coherence tomography (OCT). METHODS: Patients included in the ABSORB EXTEND (ABSORB EXTEND Clinical Investigation) trial at Shonan Kamakura General Hospital underwent OCT at baseline after the index procedure and at 1 and 5 years...
May 1, 2018: Journal of the American College of Cardiology
Sonia C Labrador-Velandia, María R Sanabria
SIGNIFICANCE: The present study provides quantitative data regarding the change of indications of fluorescein angiography in a tertiary hospital. Exhaustively compiled data over more than 10 years concerning all the angiographic studies including diagnosis, first-visit/follow-up, possible relation with antiangiogenics approval, and optic coherence tomography (OCT) are presented. PURPOSE: The aim of this study was to determine the frequency and indications of fluorescein angiography before and after OCT and anti-vascular endothelial growth factor (anti-VEGF) treatment implantation...
May 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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