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https://www.readbyqxmd.com/read/30522440/molecular-epidemiology-and-clinical-features-of-hand-foot-and-mouth-disease-in-northern-thailand-in-2016-a-prospective-cohort-study
#1
Panupong Upala, Tawatchai Apidechkul, Wipob Suttana, Niwed Kullawong, Ratipark Tamornpark, Chadaporn Inta
BACKGROUND: Hand, foot and mouth disease (HFMD) is a major communicable disease in children ≤6 years old, particularly in several countries in the Asia-Pacific Region, including Thailand. HFMD impacts public health and the economy, especially in northern Thailand. METHODS: A prospective cohort study was conducted to estimate the incidence rate and to identify the serotype and clinical features of HFMD among children in northern Thailand. A validated questionnaire and throat swab were used for data collection...
December 6, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30451348/screening-of-bacterial-isolates-related-to-olive-orchard-pests-in-tunisia-using-16s-ribosomal-rna-and-evaluation-of-their-biotechnological-potential
#2
H Gharsallah, I Ksentini, N Abdelhedi, S Naayma, K Hadj Taieb, M Sahnoun, M A Triki, M Ksantini, A Leclerque
AIM: This study investigated the bacterial diversity of dead insects collected from olive tree orchards widely cultivated in Tunisia. We aimed to explore metabolic diversity, screen enzymatic activities for biotechnological applications and carry out preliminary bioassays for bio-insecticide development. METHODS AND RESULTS: A total of 50 bacteria strains were randomly isolated from 4 different biotopes situated in Sfax (Tunisia). 16S rRNA gene sequencing was used to identify 24 species, and isolates were evaluated for enzymatic activity and antimicrobial potential...
November 19, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/30431066/bioinformatics-based-study-to-detect-chemical-compounds-that-show-potential-as-treatments-for-pulmonary-thromboembolism
#3
Keyu Sun, Zichen Xie, Jiqin Wang, Meirong Ling, Yanyan Li, Chao Qiu
The objectives of the present study comprised the recognition of major genes related to pulmonary thromboembolism (PTE) and the evaluation of their functional enrichment levels, in addition to the identification of small chemical molecules that may offer potential for use in PTE treatment. The RNA expression profiling of GSE84738 was obtained from the Gene Expression Omnibus database. Following data preprocessing, the differently expressed genes (DEGs) between the PTE group and the control group were identified using the Linear Models for Microarray package...
January 2019: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30365046/identification-of-foxm1-as-a-specific-marker-for-triple%C3%A2-negative-breast-cancer
#4
Yanli Tan, Qixue Wang, Yingbin Xie, Xiaoxia Qiao, Shun Zhang, Yanan Wang, Yongbin Yang, Bo Zhang
The present study aimed to identify the therapeutic role of the forkhead box M1 (FOXM1)‑associated pathway in triple‑negative breast cancer (TNBC). Using a Cancer Landscapes‑based analysis, a gene regulatory network model was constructed. The present results demonstrated that FOXM1 occupies a key position in gene networks and is a critical regulatory gene in breast cancer. Using breast carcinoma gene expression data from The Cancer Genome Atlas, it was identified that FOXM1 expression was increased in the basal‑like breast cancer subtype compared with other breast cancer subtypes...
October 19, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30214580/high-serum-ephrin-b2-levels-predict-poor-prognosis-for-patients-with-gastric-cancer
#5
Wen-Jing Yue, Yi-Pin Liu, Ming Li, Cheng-Xia Liu, Shao-Jia Mou, Qian-Kun Li, Zi-Ping Chen
Gastric cancer is an intractable disease with a poor prognosis and limited treatment options. Its treatment remains a major clinical challenge worldwide. Ephrin-B2 is upregulated and involved in tumor growth in various types of cancer. However, the association between ephrin-B2 and prognosis of gastric cancer, and the potential of ephrin-B2 as a therapeutic target remains unknown. The present study investigated ephrin-B2 as a prognostic factor and a therapeutic target for gastric cancer. Reverse transcription-quantitative polymerase chain reaction was performed to detect the protein expression level of ephrin-B2 in gastric cancer serum samples (n=162) and healthy serum samples (n=165)...
October 2018: Oncology Letters
https://www.readbyqxmd.com/read/30186410/identification-of-key-pathways-and-biomarkers-in-sorafenib-resistant-hepatocellular-carcinoma-using-bioinformatics-analysis
#6
Danping Huang, Weiqu Yuan, Hanmin Li, Shaodong Li, Zuanguang Chen, Hongzhi Yang
Hepatocellular carcinoma (HCC) is one of the most common malignant types of cancer, with a high mortality rate. Sorafenib is the sole approved oral clinical therapy against advanced HCC. However, individual patients exhibit varying responses to sorafenib and the development of sorafenib resistance has been a new challenge for its clinical efficacy. The current study identified gene biomarkers and key pathways in sorafenib-resistant HCC using bioinformatics analysis. Gene dataset GSE73571 was obtained from the Gene Expression Omnibus (GEO) database, including four sorafenib-acquired resistant and three sorafenib-sensitive HCC phenotypes...
September 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30127948/downregulation-of-erbb3-decreases-the-proliferation-migration-and-invasion-of-cervical-cancer-cells-though-the-interaction-with-mtk-1
#7
Jingyun Du, Shihua Zhou, Li Wang, Mulan Yu, Liyan Mei
Cervical cancer is a common malignancy in females. Diagnosis and treatment of cervical cancer remains a challenge due to difficulties in the presence of tumor metastasis. Increased expression level of Erb-b2 receptor tyrosine kinase 3 (ERBB3) has previously been demonstrated to be associated with the occurrence of cervical cancer; however, the functionality of ERBB3 in the development of cervical cancer remains incompletely understood. In the present study, the expression level of ERBB3 in patients with cervical squamous cell carcinoma and cervical adenocarcinoma was detected by reverse transcription quantitative polymerase chain reaction...
September 2018: Oncology Letters
https://www.readbyqxmd.com/read/30025709/procyanidin-b2-protects-rats-from-paraquat-induced-acute-lung-injury-by-inhibiting-nlrp3-inflammasome-activation
#8
Yinling Jiang, Wanchun Yang, Shuyu Gui
Paraquat is a commonly used heterocyclic herbicide and has high toxicity by causing acute lung injury. There is no effective treatment for paraquat poisoning. We evaluated the effects of procyanidin B2, a natural dietary phytochemical, on paraquat-induced lung injury in rats. Paraquat was used to induce acute lung injury of rats, which were administered with procyanidin B2. The lung injury was evaluated by measuring the lung/body weight ratio, the histology and PMNs count. The oxidative stress was assessed by detecting ROS-mediated indices in the BALF...
October 2018: Immunobiology
https://www.readbyqxmd.com/read/29928511/srsf3-maintains-transcriptome-integrity-in-oocytes-by-regulation-of-alternative-splicing-and-transposable-elements
#9
Dang Vinh Do, Bernhard Strauss, Engin Cukuroglu, Iain Macaulay, Keng Boon Wee, Tim Xiaoming Hu, Ruiz De Los Mozos Igor, Caroline Lee, Andrew Harrison, Richard Butler, Sabine Dietmann, Ule Jernej, John Marioni, Christopher W J Smith, Jonathan Göke, M Azim Surani
The RNA-binding protein SRSF3 (also known as SRp20) has critical roles in the regulation of pre-mRNA splicing. Zygotic knockout of Srsf3 results in embryo arrest at the blastocyst stage. However, SRSF3 is also present in oocytes, suggesting that it might be critical as a maternally inherited factor. Here we identify SRSF3 as an essential regulator of alternative splicing and of transposable elements to maintain transcriptome integrity in mouse oocyte. Using 3D time-lapse confocal live imaging, we show that conditional deletion of Srsf3 in fully grown germinal vesicle oocytes substantially compromises the capacity of germinal vesicle breakdown (GVBD), and consequently entry into meiosis...
2018: Cell Discovery
https://www.readbyqxmd.com/read/29921327/enhanced-susceptibility-of-cancer-cells-to-oncolytic-rhabdo-virotherapy-by-expression-of-nodamura-virus-protein-b2-as-a-suppressor-of-rna-interference
#10
Donald Bastin, Amelia S Aitken, Adrian Pelin, Larissa A Pikor, Mathieu J F Crupi, Michael S Huh, Marie-Claude Bourgeois-Daigneault, John C Bell, Carolina S Ilkow
Antiviral responses are barriers that must be overcome for efficacy of oncolytic virotherapy. In mammalian cells, antiviral responses involve the interferon pathway, a protein-signaling cascade that alerts the immune system and limits virus propagation. Tumour-specific defects in interferon signaling enhance viral infection and responses to oncolytic virotherapy, but many human cancers are still refractory to oncolytic viruses. Given that invertebrates, fungi and plants rely on RNA interference pathways for antiviral protection, we investigated the potential involvement of this alternative antiviral mechanism in cancer cells...
June 19, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29874961/procyanidin-b2-prevents-lupus-nephritis-development-in-mice-by-inhibiting-nlrp3-inflammasome-activation
#11
Junhui He, Mingchong Sun, Sujian Tian
Lupus nephritis (LN) is a multifactorial event that contributes to the long-term mortality of systemic lupus erythematosus (SLE). Activation of NLRP3 inflammasome has been known to play a role in SLE pathogenesis. We evaluated the renal protection effects of procyanidin B2 (PCB2) and the involvement of NLRP3 in a mouse model involving MRL/lpr and MRL/MpJ mice. Kidney injury was evaluated by measuring the renal clinical and pathological features, renal immune complex deposition, and serum anti-double-stranded (anti-dsDNA) Abs...
July 2018: Innate Immunity
https://www.readbyqxmd.com/read/29850538/correlation-between-the-expression-of-pd-l1-and-clinicopathological-features-in-patients-with-thymic-epithelial-tumors
#12
Yanmei Chen, Yuping Zhang, Xiaoling Chai, Jianfang Gao, Guorong Chen, Weifen Zhang, Yunxiang Zhang
The incidence of thymic epithelial tumors (TETs) in the Chinese population was much higher than that in the North American population. In clinical treatment, the prognosis of benign tumors after surgical resection was significantly better than that of malignant tumors. Currently, the commonly used clinical indicators for TET staging included Masaoka staging and WHO (2015) pathological criteria; however, the distinction between the benign and malignant tumors and diagnosis is yet to be explored. The current study demonstrated that the expression of PD-L1 in tumor cells was correlated with the degree of TET malignancy...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29765511/immunohistochemical-analysis-of-rhamm-expression-in-normal-and-neoplastic-human-tissues-a-cell-cycle-protein-with-distinctive-expression-in-mitotic-cells-and-testicular-germ-cells
#13
Yao-Tseng Chen, Zhengming Chen, Yi-Chieh Nancy Du
Expression of Receptor for Hyaluronic Acid Mediated Motility (RHAMM) increases cellular motility and RHAMM overexpression promotes invasive phenotype and metastasis of cancer cells. RHAMM has been suggested as a biomarker for poor prognosis in several tumor types, including lung, breast, colorectal, gastric, pancreatic ductal, and ovarian cancers. RNA studies showed restricted RHAMM expression in normal tissues, but its protein expression data in tissues were limited. In light of its potential as a prognostic marker and a therapeutic target, we performed immunohistochemical analysis to systematically characterize RHAMM expression in normal and neoplastic human tissues...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29731842/effect-of-rad51c-expression-on-the-chemosensitivity-of-e%C3%AE-myc-p19-arf-cells-and-its-clinical-significance-in-breast-cancer
#14
Shao-Guang Liao, Lu Liu, Ya-Jie Wang
The aim of the present study was to investigate the chemosensitivity to anti-cancer drugs of RAD51 paralog C (RAD51C)-deficient Eμ-Myc p19Arf-/- cells, to detect the expression of RAD51C in breast cancer tissues by immunohistochemistry (IHC), and to explore their association with clinicopathological factors. Eμ-Myc p19Arf-/- cells were stably transfected with retroviruses co-expressing short hairpin-RNA against RAD51C and green fluorescent protein (GFP). A single-cell flow cytometry-based GFP competition assay was used to assess the change in sensitivity to anti-cancer drugs...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29721240/mexican-patients-with-hiv-have-a-high-prevalence-of-vertebral-fractures
#15
José Antonio Mata-Marín, Carla I Arroyo-Anduiza, María de Los Ángeles Berrospe-Silva, Alberto Chaparro-Sánchez, Ana Gil-Avila, Jesús Gaytán-Martínez
Low bone mineral density (BMD) and fragility fractures are common in individuals infected with HIV, who are undergoing antiretroviral therapy (ART). In high-income countries, dual energy X-ray absorptiometrry is typically used to evaluate osteopenia or osteoporosis in HIV infected individuals. However, this technology is unavailable in low andmiddle income countries, so a different approach is needed. The aim of this study was to use X-ray scans of the spine to determine the prevalence of and associated risk factors for vertebral fractures in HIVinfected patients in a tertiary-care hospital in Mexico...
March 29, 2018: Infectious Disease Reports
https://www.readbyqxmd.com/read/29684168/emerin-modulates-spatial-organization-of-chromosome-territories-in-cells-on-softer-matrices
#16
Roopali Pradhan, Devika Ranade, Kundan Sengupta
Cells perceive and relay external mechanical forces into the nucleus through the nuclear envelope. Here we examined the effect of lowering substrate stiffness as a paradigm to address the impact of altered mechanical forces on nuclear structure-function relationships. RNA sequencing of cells on softer matrices revealed significant transcriptional imbalances, predominantly in chromatin associated processes and transcriptional deregulation of human Chromosome 1. Furthermore, 3-Dimensional fluorescence in situ hybridization (3D-FISH) analyses showed a significant mislocalization of Chromosome 1 and 19 Territories (CT) into the nuclear interior, consistent with their transcriptional deregulation...
June 20, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29644962/effects-of-curcumin-on-performance-antioxidation-intestinal-barrier-and-mitochondrial-function-in-ducks-fed-corn-contaminated-with-ochratoxin-a
#17
D Ruan, W C Wang, C X Lin, A M Fouad, W Chen, W G Xia, S Wang, X Luo, W H Zhang, S J Yan, C T Zheng, L Yang
Curcumin has been attributed with antioxidant, anti-inflammatory, antibacterial activities, and has shown highly protective effects against enteropathogenic bacteria and mycotoxins. Ochratoxin A (OTA) is one of the major intestinal pathogenic mycotoxins. The possible effect of curcumin on the alleviation of enterotoxicity induced by OTA is unknown. The effects of dietary curcumin supplementation on OTA-induced oxidative stress, intestinal barrier and mitochondrial dysfunctions were examined in young ducks. A total of 540 mixed-sex 1-day-old White Pekin ducklings with initial BW (43...
April 12, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29599443/genome-wide-identification-of-natural-rna-aptamers-in-prokaryotes-and-eukaryotes
#18
Sidika Tapsin, Miao Sun, Yang Shen, Huibin Zhang, Xin Ni Lim, Teodorus Theo Susanto, Siwy Ling Yang, Gui Sheng Zeng, Jasmine Lee, Alexander Lezhava, Ee Lui Ang, Lian Hui Zhang, Yue Wang, Huimin Zhao, Niranjan Nagarajan, Yue Wan
RNAs are well-suited to act as cellular sensors that detect and respond to metabolite changes in the environment, due to their ability to fold into complex structures. Here, we introduce a genome-wide strategy called PARCEL that experimentally identifies RNA aptamers in vitro, in a high-throughput manner. By applying PARCEL to a collection of prokaryotic and eukaryotic organisms, we have revealed 58 new RNA aptamers to three key metabolites, greatly expanding the list of natural RNA aptamers. The newly identified RNA aptamers exhibit significant sequence conservation, are highly structured and show an unexpected prevalence in coding regions...
March 29, 2018: Nature Communications
https://www.readbyqxmd.com/read/29510760/cysteine-peptidases-of-eudiplozoon-nipponicum-a-broad-repertoire-of-structurally-assorted-cathepsins-l-in-contrast-to-the-scarcity-of-cathepsins-b-in-an-invasive-species-of-haematophagous-monogenean-of-common-carp
#19
Lucie Jedličková, Hana Dvořáková, Jan Dvořák, Martin Kašný, Lenka Ulrychová, Jiří Vorel, Vojtěch Žárský, Libor Mikeš
BACKGROUND: Cysteine peptidases of clan CA, family C1 account for a major part of proteolytic activity in the haematophagous monogenean Eudiplozoon nipponicum. The full spectrum of cysteine cathepsins is, however, unknown and their particular biochemical properties, tissue localisation, and involvement in parasite-host relationships are yet to be explored. METHODS: Sequences of cathepsins L and B (EnCL and EnCB) were mined from E. nipponicum transcriptome and analysed bioinformatically...
March 6, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29453387/structural-determinants-of-the-sine-b2-element-embedded-in-the-long-non-coding-rna-activator-of-translation-as-uchl1
#20
Peter Podbevšek, Francesca Fasolo, Carlotta Bon, Laura Cimatti, Sabine Reißer, Piero Carninci, Giovanni Bussi, Silvia Zucchelli, Janez Plavec, Stefano Gustincich
Pervasive transcription of mammalian genomes leads to a previously underestimated level of complexity in gene regulatory networks. Recently, we have identified a new functional class of natural and synthetic antisense long non-coding RNAs (lncRNA) that increases translation of partially overlapping sense mRNAs. These molecules were named SINEUPs, as they require an embedded inverted SINE B2 element for their UP-regulation of translation. Mouse AS Uchl1 is the representative member of natural SINEUPs. It was originally discovered for its role in increasing translation of Uchl1 mRNA, a gene associated with neurodegenerative diseases...
February 16, 2018: Scientific Reports
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