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Context pain

Neeraj Purohit, Nicholas Hancock, Asif Saifuddin
The patellofemoral joint is a complex joint that relies on both bone and soft tissues for its stability. Dysfunction of the patellofemoral joint, whether pain or instability, is a common cause of medial consultation. Thorough clinical and imaging assessment is important for managing these patients, who may require a combination of a bony and soft tissue surgical procedure. Trochlear dysplasia, a cause of anterior knee pain and patellar instability, has been classified using conventional radiography. Radiographic signs on a lateral projection, such as the "double contour" sign and the "crossing sign", can alert the radiologist to the grade of trochlear dysplasia...
December 12, 2018: Skeletal Radiology
Danique R M Vlaskamp, Benjamin J Shaw, Rosemary Burgess, Davide Mei, Martino Montomoli, Han Xie, Candace T Myers, Mark F Bennett, Wenshu XiangWei, Danielle Williams, Saskia M Maas, Alice S Brooks, Grazia M S Mancini, Ingrid M B H van de Laar, Johanna M van Hagen, Tyson L Ware, Richard I Webster, Stephen Malone, Samuel F Berkovic, Renate M Kalnins, Federico Sicca, G Christoph Korenke, Conny M A van Ravenswaaij-Arts, Michael S Hildebrand, Heather C Mefford, Yuwu Jiang, Renzo Guerrini, Ingrid E Scheffer
OBJECTIVE: To delineate the epileptology, a key part of the SYNGAP1 phenotypic spectrum, in a large patient cohort. METHODS: Patients were recruited via investigators' practices or social media. We included patients with (likely) pathogenic SYNGAP1 variants or chromosome 6p21.32 microdeletions incorporating SYNGAP1 . We analyzed patients' phenotypes using a standardized epilepsy questionnaire, medical records, EEG, MRI, and seizure videos. RESULTS: We included 57 patients (53% male, median age 8 years) with SYNGAP1 mutations (n = 53) or microdeletions (n = 4)...
December 12, 2018: Neurology
Milena Pereira Pondé, Francesca Maria Niccoletta Bassi Arcand, Litza Andrade Cunha, Cécile Rousseau
This article describes how autism spectrum disorder is experienced in the context of immigrant families and how the meaning of this condition, proposed by professionals in the host country, is negotiated between families and healthcare providers. The study sample consists of 44 parents of different nationalities and their 35 children with autism spectrum disorder (ASD) living in a socioeconomically deprived neighborhood of Montreal, Canada. Individual parent interviews were audiotaped and transcribed for subsequent analysis...
December 13, 2018: Transcultural Psychiatry
Jan M Keppel Hesselink, Michael E Schatman
The repurposing of old drugs for new indications is becoming more accepted as a cost-efficient solution for complicated health problems. However, older drugs are often forgotten when they are not repositioned. This analysis makes a case for re-exploration of dermorphin for intrathecal use in postoperative pain and in a palliative context, with the goal of re-establishing this compound. Dermorphin was isolated from the skin of an Amazonian frog, characterized and identified as a bioactive heptapeptide by Vittorio Erspamer's research group in the early 1980s...
2018: Journal of Pain Research
Maichou Lor, Theresa A Koleck, Suzanne Bakken
Objective: To systematically synthesize the literature on information visualizations of symptoms included as National Institute of Nursing Research common data elements and designed for use by patients and/or healthcare providers. Methods: We searched CINAHL, Engineering Village, PsycINFO, PubMed, ACM Digital Library, and IEEE Explore Digital Library to identify peer-reviewed studies published between 2007 and 2017. We evaluated the studies using the Mixed Methods Appraisal Tool (MMAT) and a visualization quality score, and organized evaluation findings according to the Health Information Technology Usability Evaluation Model...
December 7, 2018: Journal of the American Medical Informatics Association: JAMIA
Daniela Ohlendorf, Christian Maurer, Elisabeth Bolender, Veronica Kocis, Martha Song, David A Groneberg
INTRODUCTION: Musicians often perform in forced postures over a long period of time, which in the worst case may lead to playing-related musculoskeletal disorders. In this context, the ergonomics of the musician's chair (construction and surface quality) can be an influencing factor, with impact on the seating position of the upper body and the pressure distribution of the bottom. Therefore, the relationship between different musician chairs and musicians of different playing levels (professional, amateur or student) was analyzed in order to gain useful insights whether playing experience, playing level, playing style (symmetrical or asymmetrical) or gender have an impact...
2018: PloS One
Chen X Chen, Kurt Kroenke, Timothy Stump, Jacob Kean, Erin E Krebs, Matthew J Bair, Teresa Damush, Patrick O Monahan
The PROMIS Pain Interference (PROMIS-PI) scales are reliable and publicly accessible; however, little is known about how responsive they are to detect change in clinical trials and how their responsiveness compares to legacy measures. The study purpose was to evaluate responsiveness for the PROMIS-PI scales and to compare their responsiveness with legacy pain measures. We used data from three clinical trials totaling 759 participants. The clinical trials included patients with chronic low back pain (n= 261), chronic back or osteoarthritis pain (n = 240), and a history of stroke (n= 258)...
December 5, 2018: Journal of Pain: Official Journal of the American Pain Society
A Orlando Ortiz, Alexandre de Moura, Blake A Johnson
Postsurgical spine imaging actually commences with the preoperative and perioperative imaging examinations that are performed before and during the patient's surgical procedure, respectively. It is in this context that postsurgical spine imaging examinations are best evaluated with a better appreciation of the changes, sometimes dramatic, that can occur following spine surgery. Careful follow-up is the rule in spine surgery, and these patients will have multiple imaging examinations over time. Some studies are performed immediately due to possible complications or exacerbation of pain symptoms, whereas others are used to assess the status of a fusion procedure...
December 2018: Seminars in Ultrasound, CT, and MR
Z F Ma, N Yusof, N Hamid, R M Lawenko, W M Z Wan Mohammad, M T Liong, H Sugahara, T Odamaki, J Xiao, Y Y Lee
Individuals in a community who developed irritable bowel syndrome (IBS) after major floods have significant mental health impairment. We aimed to determine if Bifidobacterium infantis M-63 was effective in improving symptoms, psychology and quality of life measures in flood-affected individuals with IBS and if the improvement was mediated by gut microbiota changes. Design was non-randomised, open-label, controlled before-and-after. Of 53 participants, 20 with IBS were given B. infantis M-63 (1×109 cfu/sachet/day) for three months and 33 were controls...
December 10, 2018: Beneficial Microbes
José Miguel Martínez Sanz, Adrián Gómez Arenas, Miguel García-Jaén, Isabel Sospedra, Aurora Norte, Juan Manuel Cortell-Tormo
BACKGROUND: the Valencian Network of Healthy Public Universities (RVUPS) is part of the healthy environments of the World Health Organization (WHO). The aim of the network is to achieve healthier universities through different lines of action, emphasizing the promotion of physical activity and sports. AIM: the purpose of this study was to analyze and review the activities developed by the RVUPS on the promotion of FA and to assess, through key informants, the need to implement an AF service within the university context...
December 3, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Christian Baeuchl, Michael Hoppstädter, Patric Meyer, Herta Flor
Contingency awareness during conditioning describes the phenomenon of becoming consciously aware of the association between a conditioned stimulus (CS) and an unconditioned stimulus (US). Despite the fact that contingency awareness is necessary for associative learning in some conditioning paradigms, its role in contextual fear conditioning, a variant that uses a context-CS (CTX) instead of a cue, has not been characterized thus far. We investigated if contingency awareness is a prerequisite for contextual fear conditioning and if subjects classified as aware differ from unaware subjects on a hemodynamic, autonomic, and behavioral level...
December 6, 2018: Cognitive, Affective & Behavioral Neuroscience
Rena Gatzounis, Geert Crombez, Martien G S Schrooten, Johan W S Vlaeyen
Activity interruptions, namely temporary suspensions of an ongoing task with the intention to resume it later, are common in pain. First, pain is a threat signal that urges us to interrupt ongoing activities in order to manage the pain and its cause. Second, activity interruptions are used in chronic pain management. However, activity interruptions by pain may carry costs for activity performance. These costs have recently started to be systematically investigated. We review the evidence on the consequences of activity interruptions by pain for the performance of the interrupted activity...
December 5, 2018: Pain Management
Anna R Parker, Lori A Forster, Deborah J Baro
Neurons operate within defined activity limits, and feedback control mechanisms dynamically tune ionic currents to maintain this optimal range. This study describes a novel, rapid feedback mechanism that uses SUMOylation to continuously adjust ionic current densities according to changes in activity. <u>S</u>mall <u>U</u>biquitin-like <u>MO</u>difier (SUMO) is a peptide that can be post-translationally conjugated to ion channels to influence their surface expression and biophysical properties...
November 30, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Esther Yakobov, Carlos Suso-Ribera, Tudor Vrinceanu, Heather Adams, Michael Sullivan
Recent research has revealed robust cross-sectional and prospective associations between perceived injustice, pain, disability, and depressive symptoms in patients with chronic pain. To date, research has proceeded from the assumption that perceived injustice arises as a consequence of debilitating injury or illness. However, it is possible that perceived injustice might have trait-like characteristics, persisting even in the absence of an injustice-related eliciting event. The aim of the present study was to develop and test a measure of trait perceived injustice (Trait Injustice Experiences Questionnaire; T-IEQ)...
November 29, 2018: Journal of Pain: Official Journal of the American Pain Society
Jacqui R Clark, Peter C Goodwin, Gillian Yeowell
BACKGROUND: Central sensitisation pain is a predominant mechanism in a proportion of individuals with non-specific chronic low back pain and is associated with poor outcomes. It is proposed that the pre-morbid experiences and contexts may be related to the development of central sensitisation. OBJECTIVES: The objective of this study was to explore the pre-morbid experiences and personal characteristics of participants with central sensitisation pain from a non-specific chronic low back pain population...
November 8, 2018: Brazilian Journal of Physical Therapy
Brady T Williams, Nathan J Redlich, Dara J Mickschl, Steven I Grindel
BACKGROUND: Recent orthopedic research has questioned the effect of opioid use on surgical outcomes. This study investigated this in the context of arthroscopic rotator cuff repair. We hypothesized that preoperative opioid use would be associated with inferior outcomes and greater postoperative opioid requirements. METHODS: A database query identified adult patients with full-thickness or partial-thickness supraspinatus tears surgically treated between 2011 and 2015...
November 29, 2018: Journal of Shoulder and Elbow Surgery
Milad Modabber, Andrei F Dan, Razek G Coussa, Michael Flanders
OBJECTIVE: To characterize the ocular response to retrobulbar anaesthesia and to evaluate the efficacy of retrobulbar anaesthesia for adjustable strabismus surgery in adults. DESIGN: Prospective observational study. PARTICIPANTS: Adult patients undergoing adjustable strabismus surgery under retrobulbar anaesthesia. METHODS: Surgical success was defined by ocular alignment within 10 prism diopters (PD) of orthotropia for horizontal rectus surgery and within 5 PD for vertical rectus surgery...
December 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Dante Duarte, Luis Eduardo Coutinho Castelo-Branco, Elif Uygur Kucukseymen, Felipe Fregni
Fibromyalgia affects more than 5 million people in the United States and has a detrimental impact on individuals' quality of life. Current pharmacological treatments provide limited benefits to relieve the pain of fibromyalgia, along with a risk of adverse effects; a scenario that explains the increasing interest for multimodal approaches. A tailored strategy to focus on this dysfunctional endogenous pain inhibitory system is transcranial direct current stimulation (tDCS) of the primary motor cortex. By combining tDCS with aerobic exercise, the effects can be optimized...
December 3, 2018: Expert Review of Medical Devices
Rosario Fernández-Peña, José Luis Molina, Oliver Valero
In the context of chronic illness, the individual's social and relational environment plays a critical role as it can provide the informal support and care over time, beyond healthcare and social welfare institutions. Social Network Analysis represents an appropriate theoretical and methodological approach to study and understand social support since it provides measures of personal network structure, composition and functional content. The aim of this mixed method study is to present the usefulness of Personal Network Analysis to explore social support in the context of chronic pain...
November 29, 2018: International Journal of Environmental Research and Public Health
Aurora Naa-Afoley Quaye, Yi Zhang
Objective: There is no consensus on the optimal perioperative management of patients on buprenorphine (BUP) for opioid use disorder (OUD). This article will review the available literature on BUP and the analgesic efficacy of BUP combined with full mu-opioid agonists and discuss the conflicting management strategies in the context of acute pain and our institution's protocol for the periprocedural management of BUP. Methods: We searched published data on BUP periprocedural management from inception through March 2018 without language restrictions...
November 30, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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