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https://www.readbyqxmd.com/read/30335683/comprehensive-analysis-of-long-non-coding-rna-expression-in-dorsal-root-ganglion-reveals-cell-type-specificity-and-dysregulation-following-nerve-injury
#1
Georgios Baskozos, John M Dawes, Jean S Austin, Ana Antunes-Martins, Lucy McDermott, Alex J Clark, Teodora Trendafilova, Jon G Lees, Stephen B McMahon, Jeffrey S Mogil, Christine Orengo, David L Bennett
Dorsal root ganglion (DRG) neurons provide connectivity between peripheral tissues and spinal cord. Transcriptional plasticity within DRG sensory neurons after peripheral nerve injury contributes to nerve repair but also leads to maladaptive plasticity, including the development of neuropathic pain. This study presents tissue and neuron specific expression profiling of both known and novel Long Non-Coding RNAs (LncRNAs) in rodent DRG following nerve injury. We have identified a large number of novel LncRNAs expressed within rodent DRG, a minority of which were syntenically conserved between mouse, rat and human and which including both- intergenic and antisense LncRNAs...
October 16, 2018: Pain
https://www.readbyqxmd.com/read/30333942/a-model-of-the-intersection-of-pain-and-opioid-misuse-in-children-and-adolescents
#2
Genevieve F Dash, Anna C Wilson, Benjamin J Morasco, Sarah W Feldstein Ewing
Despite being a significant public health concern, the role of opioid prescriptions in potentiating risk of opioid misuse in the context of pediatric pain has been under-investigated. To address this gap, the present review identifies theory-based hypotheses about these associations, reviews the extant literature on opioid prescriptions that supports these hypotheses, and provides routes for future empirical studies. A multi-level model of mechanisms through which opioid prescriptions may impact pain and other negative outcomes in youth, including risk for opioid misuse and related problems, is proposed with particular attention paid to the role that psychologists can play in informing policies and developing preventative interventions in healthcare settings...
September 2018: Clinical Psychological Science
https://www.readbyqxmd.com/read/30333099/the-platelet-nlrp3-inflammasome-is-upregulated-in-sickle-cell-disease-via-hmgb1-tlr4-and-bruton-tyrosine-kinase
#3
Sebastian Vogel, Taruna Arora, Xunde Wang, Laurel Mendelsohn, James Nichols, Darlene Allen, Arun S Shet, Christian A Combs, Zenaide M N Quezado, Swee Lay Thein
A key inflammatory mechanism recently identified in platelets involves the Nod-like receptor nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) and Bruton tyrosine kinase (BTK), which control activation of caspase-1 within inflammasome complexes. We investigated platelet caspase-1 activity in the context of sickle cell disease (SCD) directly in platelets isolated from SCD patients (n = 24) and indirectly by incubating platelets from healthy subjects with plasma obtained from SCD patients (n = 20), both in steady state and during an acute pain crisis (paired samples)...
October 23, 2018: Blood Advances
https://www.readbyqxmd.com/read/30327633/competitive-intensity-modulates-the-pain-empathy-response-an-event-related-potentials-study
#4
Pinchao Luo, Yu Pang, Beibei Li, Jing Jie, Mengdi Zhuang, Shuting Yang, Xifu Zheng
Previous studies have widely reported that competition modulates an individual's ability to empathize with pain experienced by others. What remains to be clarified, however, is how modulations in the intensity of competition might affect this type of empathy. To investigate this, we first used a Eriksen Flanker task to set different competitive intensity context (high competitive intensity, HCI; medium competitive intensity, MCI; low competitive intensity, LCI). Then we used a recognition task as a competitive task, in which we recorded event-related potentials (ERP) while participants viewed static images of body parts in painful and non-painful situations...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30327192/-elaboration-and-evaluation-of-a-therapeutic-education-program-in-cancer-pain-management
#5
REVIEW
Virginie Prevost, Bénédicte Clarisse, Natacha Heutte, Alexandra Leconte, Cécile Bisson, Rachel Bignon, Sonia Cauchin, Maryline Feuillet, Sylvie Gehanne, Maud Gicquère, Marie-Christine Grach, Cyril Guillaumé, Christine Le Gal, Joelle Le Garrec, Franck Lecaer, Isabelle Lepleux, Anne-Laure Millet, Marie-Claude Ropartz, Nathalie Roux, Virith Sep Hieng, Carole Van Delook, Constance Bechet, Aline Le Chevalier, Claire Delorme
Pain, one of the most feared symptoms for patients with cancer, remains insufficiently alleviated and impairs quality of life. Therapeutic patient education (TPE) is a relevant approach to this problem while allowing patients to develop skills to better manage their pain. In the "Basse-Normandie" French region, the management of pain relies on two organized networks, thus allowing proximity and accessibility for all concerned. In this context, our team has begun a broad five-step research program that is part of a regional health policy: (1) training in TPE of 10 doctor/nurse pairs; (2) identification of educational expectations of patients and their relatives in the field of cancer pain; (3) design and optimization of a TPE program dedicated to cancer pain; (4) regional pilot study aiming to assess the feasibility, quality and transferability of the program; (5) evaluation of the TPE program by interventional comparative randomization at the national level...
October 13, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/30326246/visual-cues-of-threat-elicit-greater-steady-state-electroencephalographic-responses-than-visual-reminders-of-death
#6
Elia Valentini, Istvan L Gyimes
Terror management theory (TMT) suggests that reminders of death activate an exclusive anxiety mechanism different from the one activated by other types of symbolic threats. This notion is supported by evidence showing how experimental participants verbally reflecting on their own death are then influenced in their opinions and behaviours. A previous study showed that magnitude of electroencephalography (EEG) activity is greater when images depicting death-related content are coupled with painful thermal stimuli compared to threat-related content...
October 13, 2018: Biological Psychology
https://www.readbyqxmd.com/read/30324170/a-developmental-arrest-interruption-and-identity-in-adolescent-chronic-pain
#7
Abbie Jordan, Melanie Noel, Line Caes, Hannah Connell, Jeremy Gauntlett-Gilbert
Introduction: Although the pediatric pain literature has explored the role of developmental factors in young children's acute pain, relatively less is known about specific developmental challenges in adolescents with chronic pain. Objectives: To meet this knowledge gap, this study sought to adopt an idiographic phenomenological approach to examine how adolescents make sense of their own development in the context of living with chronic pain. Methods: Semistructured interviews were conducted with ten adolescents (12-17 years; 7 females) recruited from a tertiary care pain treatment programme...
September 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/30322590/non-pharmacological-treatment-for-neuropathic-pain-invasive-and-non-invasive-cortical-stimulation
#8
REVIEW
X Moisset, J-P Lefaucheur
The use of medications in chronic neuropathic pain may be limited with regard to efficacy and tolerance. Therefore, non-pharmacological approaches, using electrical stimulation of the cortex has been proposed as an alternative. First, in the early nineties, surgically-implanted epidural motor cortex stimulation (EMCS) was proven to be effective to relieve refractory neuropathic pain. Later, non-invasive stimulation techniques were found to produce similar analgesic effects, at least by means of repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex (M1)...
October 12, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/30322452/procedure-specific-pain-management-prospect-an-update
#9
REVIEW
Brian Lee, Stephan A Schug, Girish P Joshi, Henrik Kehlet
Post-operative pain management protocols may be optimised by examining procedure-specific evidence and outcomes. This recognition led to the formation of the PROcedure-SPECific Pain ManagemenT (PROSPECT) collaboration of anaesthesiologists and surgeons. The aim of PROSPECT is to provide practical and evidence-based recommendations to prevent and treat post-operative pain after specific surgical procedures, thereby overcoming the limitations of generic, non-specific guidelines. Updates in the methodology of PROSPECT in 2017 have placed an increased emphasis on the clinical relevance of studies, including a focus on interventions in the context of multimodal analgesia strategies and consideration of risks and benefits of interventions in specific surgical settings...
June 2018: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/30321900/-classical-massage-and-acupuncture-in-chronic-back-pain-non-inferiority-randomised-trial
#10
Erika Klassen, Karl-Ruediger Wiebelitz, André-Michael Beer
BACKGROUND: Currently, there is a need for scientific evidence on the efficacy of classical massage therapy for chronic, unspecific back pain, especially for the improvement in functional impairment and long-term pain reduction. According to the National Health Care Guidelines, classical massage for nonspecific low back pain may only be prescribed in combination with exercise therapy and a share of the remuneration. Acupuncture, on the other hand, is recognised in the guidelines as an independent treatment for chronic back pain and is remunerated by health insurance companies...
October 15, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/30321570/hemangioblastoma-of-the-optic-nerve
#11
REVIEW
Lindsay A McGrath, Hardeep Singh Mudhar, Sachin M Salvi
Optic nerve hemangioblastoma (ONH) is a rare tumor that is usually unilateral and most commonl occurs in the context of von Hippel-Lindau (VHL) disease. Differential diagnosis is based on clinical history and imaging. Magnetic resonance imaging with gadolinium enhancement is the most useful imaging modality as it can reveal flow voids and an absence of dural attachment, differentiating ONH from other more commonly encountered optic nerve tumors. ONH are usually well-circumscribed vascular lesions composed of stromal cells and vascular endothelial cells...
October 12, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/30320515/emotional-and-cognitive-modulation-of-cybersickness-the-role-of-pain-catastrophizing-and-body-awareness
#12
Justin Maximilian Mittelstaedt, Jan Wacker, Dirk Stelling
OBJECTIVE: The goal was to investigate the influence of the tendency to catastrophize somatic symptoms and body awareness on motion-related sickness. BACKGROUND: Influences of emotional and cognitive-evaluative processes on the genesis of motion sickness or cybersickness have rarely been investigated. Brain imaging studies showed activation during cybersickness, resembling the pattern found for pain processing. Two aspects often investigated in this context are pain catastrophizing and body awareness...
October 15, 2018: Human Factors
https://www.readbyqxmd.com/read/30319486/the-role-of-musical-attributes-in-music-induced-analgesia-a-preliminary-brief-report
#13
Krzysztof Basiński, Agata Zdun-Ryżewska, Mikołaj Majkowicz
Music-induced analgesia (MIA) is the ability of music to influence pain perception. Although this phenomenon has been extensively studied in recent years, only a few studies have addressed what musical characteristics are optimal for MIA. Here, we present a novel approach to this topic, using a recently proposed model of music attribute preferences. The model addresses three musical dimensions: arousal, valence, and depth. Thirty participants (15 women and 15 men, M age = 37.1 years, standard deviation = 15...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30319460/online-survey-of-medical-and-psychological-professionals-on-structured-instruments-for-the-assessment-of-work-ability-in-psychiatric-patients
#14
Roman Schleifer, Alex Gamma, Ingeborg Warnke, Mounira Jabat, Wulf Rössler, Michael Liebrenz
Objective: To evaluate perceived needs and difficulties related to instruments for assessing work ability in individuals with mental disorders. Method: We conducted an online survey of 104 German-speaking medico-legal experts (forensic psychiatric and psychology experts, insurance physicians) and therapists. Results: The large majority of respondents reported they would welcome a standardized, structured instrument for the assessment of work ability. High predictiveness, inter-rater agreement, comprehensibility for laymen, and symptom validity were desired in roughly equal measure as the main characteristic of such an instrument...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30315648/personal-responsibility-modulates-neural-representations-of-anticipatory-and-experienced-pain
#15
Min Pu, Rongjun Yu
An individual's sense of personal responsibility is crucial for adaptive functioning in ever-changing social situations. This study investigated how the sense of personal responsibility affected the neural dynamics of anticipating one's own pain and another person's pain, using EEG. Participants played a cooperation game in which either the participant (self-context) or the confederate (other-context) received a mild electric shock whenever one of them erred. At the anticipatory stage of pain, feedback-related negativity (FRN) and P300 were sensitive to the degree of responsibility in both contexts...
October 13, 2018: Psychophysiology
https://www.readbyqxmd.com/read/30314468/how-general-practitioners-would-deprescribe-in-frail-oldest-old-with-polypharmacy-the-less-study
#16
Sophie Mantelli, Katharina Tabea Jungo, Zsofia Rozsnyai, Emily Reeve, Clare H Luymes, Rosalinde K E Poortvliet, Arnaud Chiolero, Nicolas Rodondi, Jacobijn Gussekloo, Sven Streit
BACKGROUND: Many oldest-old (> 80-years) with multimorbidity and polypharmacy are at high risk of inappropriate use of medication, but we know little about whether and how GPs would deprescribe, especially in the frail oldest-old. We aimed to determine whether, how, and why Swiss GPs deprescribe for this population. METHODS: GPs took an online survey that presented case-vignettes of a frail oldest-old patient with and without history of cardiovascular disease (CVD) and asked if they would deprescribe any of seven medications...
October 12, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/30311715/a-review-of-spinal-and-peripheral-neuromodulation-and-neuroinflammation-lessons-learned-thus-far-and-future-prospects-of-biotype-development
#17
REVIEW
Krishnan V Chakravarthy, Fang Xing, Kelly Bruno, Alexander R Kent, Adil Raza, Rene Hurlemann, Thomas M Kinfe
BACKGROUND: There is increasing literature evidence both clinically and experimentally on the existence of potent, adaptive interactions between the central and peripheral aspects of the neuroimmune system in the genesis and maintenance of chronic neuropathic extremity pain and nociceptive back pain. The neuroinflammatory pathways are modulated by the interaction of pro- and anti-inflammatory cytokines and chemokines, which are released by peripheral immune system-derived cell species (macrophages and leukocytes)...
October 12, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/30310335/accurate-empathy-of-romantic-partners-increases-pain-ratings-but-promotes-recovery
#18
Binghai Sun, Lingyan Zhou, Weilong Xiao, Xiaoqian Zhao, Wenhai Zhang, Weijian Li
Background: Perceived empathy is a commonly used strategy to cope with pain and is crucial for maintaining intimacy in dyadic relationships. Materials and methods: This study used the cold pressor test to investigate how perceived empathy and relationship type interact with the subjective perception of pain and objective measures of recovery time, using heart rate as an index. One hundred and ninety participants were recruited, including 49 friend dyads and 46 romantic partner dyads...
2018: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/30309834/patient-perceptions-of-their-own-data-in-mhealth-technology-enabled-n-of-1-trials-for-chronic-pain-qualitative-study
#19
Robin L Whitney, Deborah H Ward, Maria T Marois, Christopher H Schmid, Ida Sim, Richard L Kravitz
BACKGROUND: N-of-1 (individual comparison) trials are a promising approach for comparing the effectiveness of 2 or more treatments for individual patients; yet, few studies have qualitatively examined how patients use and make sense of their own patient-generated health data (PGHD) in the context of N-of-1 trials. OBJECTIVE: The objective of our study was to explore chronic pain patients' perceptions about the PGHD they compiled while comparing 2 chronic pain treatments and tracking their symptoms using a smartphone N-of-1 app in collaboration with their clinicians...
October 11, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/30306810/-so-many-women-suffer-in-silence-a-thematic-analysis-of-women-s-written-accounts-of-coping-with-endometriosis
#20
Sarah Grogan, Emma Turley, Jennifer Cole
OBJECTIVE: To understand women's experiences of coping with endometriosis, and impact on their lives. DESIGN: Women accessed an online questionnaire through a U.K.-based endometriosis charity website. METHODS: Thirty-four women, aged 22-56 years, with self-reported medically-diagnosed endometriosis, 30 of whom were White, responded to open-ended questions, analysed using inductive thematic analysis. RESULTS: Participants spoke about their lives being a constant struggle, where they tried to maintain their personal and working lives whilst dealing with long-term pain...
October 11, 2018: Psychology & Health
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